#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P19357	uniprotkb:Q3L7M0	intact:EBI-915426|uniprotkb:P97900|ensembl:ENSRNOP00000023256	intact:EBI-920431|ensembl:ENSRNOP00000070562|uniprotkb:Q80WF5|uniprotkb:Q8K3Z1	psi-mi:glut4_rat(display_long)|uniprotkb:Glucose transporter type 4, insulin-responsive(gene name synonym)|uniprotkb:Slc2a4(gene name)|psi-mi:Slc2a4(display_short)|uniprotkb:Glut4(gene name synonym)	psi-mi:ggta1_rat(display_long)|uniprotkb:Ggta1(gene name)|psi-mi:Ggta1(display_short)|uniprotkb:Ggta-1(gene name synonym)|uniprotkb:"UDP-galactose:beta-D-galactosyl-1,4-N-acetyl-D-glucosaminide alpha-1,3-galactosyltransferase"(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Foster et al. (2006)	pubmed:16396496|mint:MINT-5218203	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-921030	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2711|refseq:NP_036883.1|refseq:XP_006246658.1|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007611"(learning or memory)|go:"GO:0007614"(short-term memory)|go:"GO:0007616"(long-term memory)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010021"(amylopectin biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031550"(positive regulation of brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044381"(glucose import in response to insulin stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046323"(glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0098694"(regulation of synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0098793"(presynapse)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002441("Glucose transporter, type 4 (GLUT4)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-189200|ensembl:ENSRNOG00000017226(gene)|ensembl:ENSRNOT00000023256(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)	rgd:629476|refseq:XP_008759922.1|refseq:XP_008759923.1|ensembl:ENSRNOG00000019179(gene)|ensembl:ENSRNOT00000085756(transcript)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005975"(carbohydrate metabolic process)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016757"(glycosyltransferase activity)|go:"GO:0031982"(vesicle)|go:"GO:0031985"(Golgi cisterna)|go:"GO:0032580"(Golgi cisterna membrane)|go:"GO:0033580"(protein galactosylation at cell surface)|go:"GO:0046872"(metal ion binding)|go:"GO:0047276"(N-acetyllactosaminide 3-alpha-galactosyltransferase activity)|interpro:IPR005076(Glycosyl transferase, family 6)|interpro:IPR029044|refseq:NP_663707.1|refseq:XP_006234095.1|refseq:XP_006234099.1|refseq:XP_017446957.1|refseq:XP_017446958.1	-	-	-	caution:"The participant EBI-349571(P68370) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919386(Q7TP47) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920972(Q5XIP9) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-916419(P11980) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919578(Q8R491) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920554(Q5U3Z7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920647(Q5U2X8) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920585(Q7TP24) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-779677(P05426) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-915744(P02454) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|agonist:Insulin was shown to increase or decrease GLUT4 protein interactions in specific cases.|comment:"Insulin decreased GLUT4 interactions with the following proteins: Q9ER30 (Sarcosin), P09527 (Rab-7), O88960 (N-ethylmaleimide sensitive), P09456 (PKA I regulatory subunit), P27881 (Hexokinase type II), P07872 (Acyl-coenzyme A oxidase), Q6DGF1 (Isocitrate dehydrogenase), Q9EQX9 (Ubiquitin-conjugating), Q63446 (Polyubiquitin), P24268 (Cathepsin D), Q91XW0 (Heat shock protein 86), Q5FVH0 (unknown), P58405 (Striatin 3), Q62667 (Major vault protein), Q66H50 (unknown), Q09167 (splicing factor), Q9JHU5 (Arfaptin 1)."|comment:"Insulin increased GLUT4 interaction with the following proteins:Q9Z1P2 (R-actinin-1), P45592 (Cofilin), Q9QXQ0 (R-actinin-4), P26473 (ADP-ribosylation factor), P26437 (ADP-ribosylation factor),   Q7TNP1 (Basigin 2), Q6P6R2 (Dihydrolipoamide dehydrogenase),   P04797 (GAPDH), Q63081 (Protein disulfide isomerase), P29457 (47 kDa heat shock protein), Q9R1J8 (Leprecan), O88638 (Putative eps protein),   Q64375 (Synaptonemal complex)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:NDPK - Interactions involving proteins containing InterPro domain IPR001564, Nucleoside diphosphate kinase, core.	taxid:10116(rat-l6)|taxid:10116(Rattus norvegicus)	-	2006/02/15	2021/11/30	rogid:PbFY2lfrty8yw40Jq7ShR7xfuV410116	rogid:umE29WCTNgGQZ0+8bx96lTaO7qg10116	intact-crc:44F3A2176D02515F|rigid:9RVm0UBcqQF4k06RGKO89Bg16Q8	false	myc tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P19357	uniprotkb:P34067	intact:EBI-915426|uniprotkb:P97900|ensembl:ENSRNOP00000023256	intact:EBI-917294|uniprotkb:P28071|uniprotkb:P97719	psi-mi:glut4_rat(display_long)|uniprotkb:Glucose transporter type 4, insulin-responsive(gene name synonym)|uniprotkb:Slc2a4(gene name)|psi-mi:Slc2a4(display_short)|uniprotkb:Glut4(gene name synonym)	psi-mi:psb4_rat(display_long)|uniprotkb:Macropain beta chain(gene name synonym)|uniprotkb:Multicatalytic endopeptidase complex beta chain(gene name synonym)|uniprotkb:Proteasome chain 3(gene name synonym)|uniprotkb:Psmb4(gene name)|psi-mi:Psmb4(display_short)|uniprotkb:Proteasome beta chain(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Foster et al. (2006)	pubmed:16396496|mint:MINT-5218203	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-921030	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2711|refseq:NP_036883.1|refseq:XP_006246658.1|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007611"(learning or memory)|go:"GO:0007614"(short-term memory)|go:"GO:0007616"(long-term memory)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010021"(amylopectin biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031550"(positive regulation of brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044381"(glucose import in response to insulin stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046323"(glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0098694"(regulation of synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0098793"(presynapse)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002441("Glucose transporter, type 4 (GLUT4)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-189200|ensembl:ENSRNOG00000017226(gene)|ensembl:ENSRNOT00000023256(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)	interpro:IPR029055|rgd:61877|interpro:IPR016050(Proteasome, beta-type subunit, conserved site)|interpro:IPR016295(Proteasome endopeptidase complex, beta subunit)|interpro:IPR001353(20S proteasome, A and B subunits)|interpro:IPR023333|reactome:R-RNO-8932339|rcsb pdb:6EPC|rcsb pdb:6EPD|rcsb pdb:6EPE|rcsb pdb:6EPF|reactome:R-RNO-174084|reactome:R-RNO-5689603|reactome:R-RNO-5689880|reactome:R-RNO-68827|reactome:R-RNO-8951664|reactome:R-RNO-1169091|reactome:R-RNO-1234176|reactome:R-RNO-1236978|reactome:R-RNO-174154|reactome:R-RNO-174178|reactome:R-RNO-174184|reactome:R-RNO-187577|reactome:R-RNO-195253|reactome:R-RNO-2467813|reactome:R-RNO-349425|reactome:R-RNO-350562|reactome:R-RNO-382556|reactome:R-RNO-450408|reactome:R-RNO-4608870|reactome:R-RNO-4641257|reactome:R-RNO-4641258|reactome:R-RNO-5358346|reactome:R-RNO-5607761|reactome:R-RNO-5610780|reactome:R-RNO-5610785|reactome:R-RNO-5632684|reactome:R-RNO-5658442|reactome:R-RNO-5668541|reactome:R-RNO-5676590|reactome:R-RNO-5687128|reactome:R-RNO-68949|reactome:R-RNO-69017|reactome:R-RNO-69481|reactome:R-RNO-69601|reactome:R-RNO-75815|reactome:R-RNO-8852276|reactome:R-RNO-8854050|reactome:R-RNO-8939236|reactome:R-RNO-8941858|reactome:R-RNO-8948751|reactome:R-RNO-983168|rcsb pdb:6TU3|go:"GO:0000502"(proteasome complex)|go:"GO:0001530"(lipopolysaccharide binding)|go:"GO:0002862"(negative regulation of inflammatory response to antigenic stimulus)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004298"(threonine-type endopeptidase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005839"(proteasome core complex)|go:"GO:0010499"(proteasomal ubiquitin-independent protein catabolic process)|go:"GO:0019774"(proteasome core complex, beta-subunit complex)|go:"GO:0036064"(ciliary basal body)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)	-	-	-	caution:"The participant EBI-349571(P68370) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919386(Q7TP47) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920972(Q5XIP9) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-916419(P11980) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919578(Q8R491) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920554(Q5U3Z7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920647(Q5U2X8) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920585(Q7TP24) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-779677(P05426) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-915744(P02454) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|agonist:Insulin was shown to increase or decrease GLUT4 protein interactions in specific cases.|comment:"Insulin decreased GLUT4 interactions with the following proteins: Q9ER30 (Sarcosin), P09527 (Rab-7), O88960 (N-ethylmaleimide sensitive), P09456 (PKA I regulatory subunit), P27881 (Hexokinase type II), P07872 (Acyl-coenzyme A oxidase), Q6DGF1 (Isocitrate dehydrogenase), Q9EQX9 (Ubiquitin-conjugating), Q63446 (Polyubiquitin), P24268 (Cathepsin D), Q91XW0 (Heat shock protein 86), Q5FVH0 (unknown), P58405 (Striatin 3), Q62667 (Major vault protein), Q66H50 (unknown), Q09167 (splicing factor), Q9JHU5 (Arfaptin 1)."|comment:"Insulin increased GLUT4 interaction with the following proteins:Q9Z1P2 (R-actinin-1), P45592 (Cofilin), Q9QXQ0 (R-actinin-4), P26473 (ADP-ribosylation factor), P26437 (ADP-ribosylation factor),   Q7TNP1 (Basigin 2), Q6P6R2 (Dihydrolipoamide dehydrogenase),   P04797 (GAPDH), Q63081 (Protein disulfide isomerase), P29457 (47 kDa heat shock protein), Q9R1J8 (Leprecan), O88638 (Putative eps protein),   Q64375 (Synaptonemal complex)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:NDPK - Interactions involving proteins containing InterPro domain IPR001564, Nucleoside diphosphate kinase, core.	taxid:10116(rat-l6)|taxid:10116(Rattus norvegicus)	-	2006/02/15	2021/11/30	rogid:PbFY2lfrty8yw40Jq7ShR7xfuV410116	rogid:rSUiQIxXvE8qeN4Gj0hwg9HDo7E10116	intact-crc:44F3A2176D02515F|rigid:9RVm0UBcqQF4k06RGKO89Bg16Q8	false	myc tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P19357	uniprotkb:Q794F9	intact:EBI-915426|uniprotkb:P97900|ensembl:ENSRNOP00000023256	intact:EBI-919315	psi-mi:glut4_rat(display_long)|uniprotkb:Glucose transporter type 4, insulin-responsive(gene name synonym)|uniprotkb:Slc2a4(gene name)|psi-mi:Slc2a4(display_short)|uniprotkb:Glut4(gene name synonym)	psi-mi:4f2_rat(display_long)|uniprotkb:Slc3a2(gene name)|psi-mi:Slc3a2(display_short)|uniprotkb:Solute carrier family 3 member 2(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Foster et al. (2006)	pubmed:16396496|mint:MINT-5218203	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-921030	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2711|refseq:NP_036883.1|refseq:XP_006246658.1|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007611"(learning or memory)|go:"GO:0007614"(short-term memory)|go:"GO:0007616"(long-term memory)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010021"(amylopectin biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031550"(positive regulation of brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044381"(glucose import in response to insulin stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046323"(glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0098694"(regulation of synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0098793"(presynapse)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002441("Glucose transporter, type 4 (GLUT4)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-189200|ensembl:ENSRNOG00000017226(gene)|ensembl:ENSRNOT00000023256(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)	rgd:3073|interpro:IPR006047(Glycosyl hydrolase, family 13, catalytic region)|interpro:IPR017853(Glycoside hydrolase, catalytic core)|refseq:NP_001258018.1|interpro:IPR031984|interpro:IPR042280|mint:Q794F9|interpro:IPR013780(Glycosyl hydrolase, family 13, all-beta)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0003824"(catalytic activity)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0005975"(carbohydrate metabolic process)|go:"GO:0009925"(basal plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0015173"(aromatic amino acid transmembrane transporter activity)|go:"GO:0015175"(neutral amino acid transmembrane transporter activity)|go:"GO:0015180"(L-alanine transmembrane transporter activity)|go:"GO:0015190"(L-leucine transmembrane transporter activity)|go:"GO:0015804"(neutral amino acid transport)|go:"GO:0015820"(leucine transport)|go:"GO:0015823"(phenylalanine transport)|go:"GO:0015827"(tryptophan transport)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0042470"(melanosome)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043330"(response to exogenous dsRNA)|go:"GO:0044225"(apical pole of neuron)|go:"GO:0045202"(synapse)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0098713"(leucine import across plasma membrane)|go:"GO:1903801"(L-leucine import across plasma membrane)|go:"GO:1904273"(L-alanine import across plasma membrane)|go:"GO:1990184"(amino acid transport complex)|reactome:R-RNO-210991|reactome:R-RNO-352230|reactome:R-RNO-71240	-	-	-	caution:"The participant EBI-349571(P68370) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919386(Q7TP47) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920972(Q5XIP9) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-916419(P11980) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919578(Q8R491) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920554(Q5U3Z7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920647(Q5U2X8) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920585(Q7TP24) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-779677(P05426) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-915744(P02454) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|agonist:Insulin was shown to increase or decrease GLUT4 protein interactions in specific cases.|comment:"Insulin decreased GLUT4 interactions with the following proteins: Q9ER30 (Sarcosin), P09527 (Rab-7), O88960 (N-ethylmaleimide sensitive), P09456 (PKA I regulatory subunit), P27881 (Hexokinase type II), P07872 (Acyl-coenzyme A oxidase), Q6DGF1 (Isocitrate dehydrogenase), Q9EQX9 (Ubiquitin-conjugating), Q63446 (Polyubiquitin), P24268 (Cathepsin D), Q91XW0 (Heat shock protein 86), Q5FVH0 (unknown), P58405 (Striatin 3), Q62667 (Major vault protein), Q66H50 (unknown), Q09167 (splicing factor), Q9JHU5 (Arfaptin 1)."|comment:"Insulin increased GLUT4 interaction with the following proteins:Q9Z1P2 (R-actinin-1), P45592 (Cofilin), Q9QXQ0 (R-actinin-4), P26473 (ADP-ribosylation factor), P26437 (ADP-ribosylation factor),   Q7TNP1 (Basigin 2), Q6P6R2 (Dihydrolipoamide dehydrogenase),   P04797 (GAPDH), Q63081 (Protein disulfide isomerase), P29457 (47 kDa heat shock protein), Q9R1J8 (Leprecan), O88638 (Putative eps protein),   Q64375 (Synaptonemal complex)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:NDPK - Interactions involving proteins containing InterPro domain IPR001564, Nucleoside diphosphate kinase, core.	taxid:10116(rat-l6)|taxid:10116(Rattus norvegicus)	-	2006/02/15	2021/11/30	rogid:PbFY2lfrty8yw40Jq7ShR7xfuV410116	rogid:gEQnTlE/6x+4eAArJn1IuzL9cJg10116	intact-crc:44F3A2176D02515F|rigid:9RVm0UBcqQF4k06RGKO89Bg16Q8	false	myc tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P19357	uniprotkb:O70351	intact:EBI-915426|uniprotkb:P97900|ensembl:ENSRNOP00000023256	intact:EBI-915644|uniprotkb:Q9QYD4	psi-mi:glut4_rat(display_long)|uniprotkb:Glucose transporter type 4, insulin-responsive(gene name synonym)|uniprotkb:Slc2a4(gene name)|psi-mi:Slc2a4(display_short)|uniprotkb:Glut4(gene name synonym)	psi-mi:hcd2_rat(display_long)|uniprotkb:3-hydroxyacyl-CoA dehydrogenase type II(gene name synonym)|uniprotkb:Type II HADH(gene name synonym)|uniprotkb:3-hydroxy-2-methylbutyryl-CoA dehydrogenase(gene name synonym)|uniprotkb:Endoplasmic reticulum-associated amyloid beta-peptide-binding protein(gene name synonym)|uniprotkb:Hsd17b10(gene name)|psi-mi:Hsd17b10(display_short)|uniprotkb:Erab(gene name synonym)|uniprotkb:Hadh2(gene name synonym)|uniprotkb:Mitochondrial ribonuclease P protein 2(gene name synonym)|uniprotkb:17-beta-estradiol 17-dehydrogenase(gene name synonym)|uniprotkb:2-methyl-3-hydroxybutyryl-CoA dehydrogenase(gene name synonym)|uniprotkb:"3-alpha-(17-beta)-hydroxysteroid dehydrogenase (NAD(+))"(gene name synonym)|uniprotkb:"3alpha(or 20beta)-hydroxysteroid dehydrogenase"(gene name synonym)|uniprotkb:7-alpha-hydroxysteroid dehydrogenase(gene name synonym)|uniprotkb:Short chain dehydrogenase/reductase family 5C member 1(gene name synonym)|uniprotkb:Short-chain type dehydrogenase/reductase XH98G2(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Foster et al. (2006)	pubmed:16396496|mint:MINT-5218203	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-921030	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2711|refseq:NP_036883.1|refseq:XP_006246658.1|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007611"(learning or memory)|go:"GO:0007614"(short-term memory)|go:"GO:0007616"(long-term memory)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010021"(amylopectin biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031550"(positive regulation of brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044381"(glucose import in response to insulin stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046323"(glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0098694"(regulation of synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0098793"(presynapse)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002441("Glucose transporter, type 4 (GLUT4)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-189200|ensembl:ENSRNOG00000017226(gene)|ensembl:ENSRNOT00000023256(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)	go:"GO:0000049"(tRNA binding)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0003857"(3-hydroxyacyl-CoA dehydrogenase activity)|go:"GO:0004303"(estradiol 17-beta-dehydrogenase activity)|go:"GO:0005496"(steroid binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0006550"(isoleucine catabolic process)|go:"GO:0006635"(fatty acid beta-oxidation)|go:"GO:0006699"(bile acid biosynthetic process)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0007569"(cell aging)|go:"GO:0008207"(C21-steroid hormone metabolic process)|go:"GO:0008209"(androgen metabolic process)|go:"GO:0008210"(estrogen metabolic process)|go:"GO:0008709"(cholate 7-alpha-dehydrogenase activity)|mint:O70351|rgd:69231|refseq:NP_113870.1|interpro:IPR002347(Glucose/ribitol dehydrogenase)|interpro:IPR020904|interpro:IPR036291|go:"GO:0018454"(acetoacetyl-CoA reductase activity)|go:"GO:0030283"("testosterone dehydrogenase [NAD(P)] activity")|go:"GO:0030331"(estrogen receptor binding)|go:"GO:0030678"(mitochondrial ribonuclease P complex)|go:"GO:0033327"(Leydig cell differentiation)|go:"GO:0042645"(mitochondrial nucleoid)|go:"GO:0042802"(identical protein binding)|go:"GO:0044594"("17-beta-hydroxysteroid dehydrogenase (NAD+) activity")|go:"GO:0047015"(3-hydroxy-2-methylbutyryl-CoA dehydrogenase activity)|go:"GO:0047035"("testosterone dehydrogenase (NAD+) activity")|go:"GO:0047044"(androstan-3-alpha,17-beta-diol dehydrogenase activity)|go:"GO:0051287"(NAD binding)|go:"GO:0051289"(protein homotetramerization)|go:"GO:0062173"(brexanolone metabolic process)|go:"GO:0070901"(mitochondrial tRNA methylation)|go:"GO:0097745"(mitochondrial tRNA 5'-end processing)|go:"GO:0106281"("chenodeoxycholate 7-alpha-dehydrogenase (NAD+) activity")|go:"GO:0106282"("isoursodeoxycholate 7-beta-dehydrogenase (NAD+) activity")|go:"GO:0106283"("ursodeoxycholate 7-beta-dehydrogenase (NAD+) activity")|go:"GO:1990180"(mitochondrial tRNA 3'-end processing)|rcsb pdb:1E3S|rcsb pdb:1E3W|rcsb pdb:1E6W|reactome:R-RNO-70895	-	-	-	caution:"The participant EBI-349571(P68370) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919386(Q7TP47) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920972(Q5XIP9) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-916419(P11980) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919578(Q8R491) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920554(Q5U3Z7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920647(Q5U2X8) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920585(Q7TP24) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-779677(P05426) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-915744(P02454) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|agonist:Insulin was shown to increase or decrease GLUT4 protein interactions in specific cases.|comment:"Insulin decreased GLUT4 interactions with the following proteins: Q9ER30 (Sarcosin), P09527 (Rab-7), O88960 (N-ethylmaleimide sensitive), P09456 (PKA I regulatory subunit), P27881 (Hexokinase type II), P07872 (Acyl-coenzyme A oxidase), Q6DGF1 (Isocitrate dehydrogenase), Q9EQX9 (Ubiquitin-conjugating), Q63446 (Polyubiquitin), P24268 (Cathepsin D), Q91XW0 (Heat shock protein 86), Q5FVH0 (unknown), P58405 (Striatin 3), Q62667 (Major vault protein), Q66H50 (unknown), Q09167 (splicing factor), Q9JHU5 (Arfaptin 1)."|comment:"Insulin increased GLUT4 interaction with the following proteins:Q9Z1P2 (R-actinin-1), P45592 (Cofilin), Q9QXQ0 (R-actinin-4), P26473 (ADP-ribosylation factor), P26437 (ADP-ribosylation factor),   Q7TNP1 (Basigin 2), Q6P6R2 (Dihydrolipoamide dehydrogenase),   P04797 (GAPDH), Q63081 (Protein disulfide isomerase), P29457 (47 kDa heat shock protein), Q9R1J8 (Leprecan), O88638 (Putative eps protein),   Q64375 (Synaptonemal complex)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:NDPK - Interactions involving proteins containing InterPro domain IPR001564, Nucleoside diphosphate kinase, core.	taxid:10116(rat-l6)|taxid:10116(Rattus norvegicus)	-	2006/02/15	2021/11/30	rogid:PbFY2lfrty8yw40Jq7ShR7xfuV410116	rogid:haa2iL54VH7fLot4uIyfXL+DMlA10116	intact-crc:44F3A2176D02515F|rigid:9RVm0UBcqQF4k06RGKO89Bg16Q8	false	myc tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P19357	uniprotkb:P62246	intact:EBI-915426|uniprotkb:P97900|ensembl:ENSRNOP00000023256	intact:EBI-347883|ensembl:ENSRNOP00000024678|ensembl:ENSRNOP00000075747|ensembl:ENSRNOP00000075906|uniprotkb:P39027|uniprotkb:P39031|uniprotkb:Q8C023|uniprotkb:Q9BV24	psi-mi:glut4_rat(display_long)|uniprotkb:Glucose transporter type 4, insulin-responsive(gene name synonym)|uniprotkb:Slc2a4(gene name)|psi-mi:Slc2a4(display_short)|uniprotkb:Glut4(gene name synonym)	psi-mi:rs15a_rat(display_long)|uniprotkb:Rps15a(gene name)|psi-mi:Rps15a(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Foster et al. (2006)	pubmed:16396496|mint:MINT-5218203	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-921030	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2711|refseq:NP_036883.1|refseq:XP_006246658.1|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007611"(learning or memory)|go:"GO:0007614"(short-term memory)|go:"GO:0007616"(long-term memory)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010021"(amylopectin biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031550"(positive regulation of brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044381"(glucose import in response to insulin stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046323"(glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0098694"(regulation of synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0098793"(presynapse)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002441("Glucose transporter, type 4 (GLUT4)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-189200|ensembl:ENSRNOG00000017226(gene)|ensembl:ENSRNOT00000023256(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)	ensembl:ENSRNOG00000018320(gene)|ensembl:ENSRNOT00000024678(transcript)|ensembl:ENSRNOT00000092282(transcript)|ensembl:ENSRNOT00000092513(transcript)|go:"GO:0003735"(structural constituent of ribosome)|go:"GO:0005737"(cytoplasm)|go:"GO:0006412"(translation)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009615"(response to virus)|go:"GO:0022626"(cytosolic ribosome)|go:"GO:0022627"(cytosolic small ribosomal subunit)|go:"GO:0045787"(positive regulation of cell cycle)|interpro:IPR000630(Ribosomal protein S8)|interpro:IPR035987|mint:P62246|reactome:R-RNO-156827|reactome:R-RNO-1799339|reactome:R-RNO-6791226|reactome:R-RNO-72649|reactome:R-RNO-72689|reactome:R-RNO-72695|reactome:R-RNO-72702|reactome:R-RNO-72706|reactome:R-RNO-975956|reactome:R-RNO-975957|rgd:619939|refseq:NP_446434.1|refseq:XP_006230159.1|refseq:XP_006230160.1	-	-	-	caution:"The participant EBI-349571(P68370) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919386(Q7TP47) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920972(Q5XIP9) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-916419(P11980) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919578(Q8R491) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920554(Q5U3Z7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920647(Q5U2X8) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920585(Q7TP24) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-779677(P05426) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-915744(P02454) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|agonist:Insulin was shown to increase or decrease GLUT4 protein interactions in specific cases.|comment:"Insulin decreased GLUT4 interactions with the following proteins: Q9ER30 (Sarcosin), P09527 (Rab-7), O88960 (N-ethylmaleimide sensitive), P09456 (PKA I regulatory subunit), P27881 (Hexokinase type II), P07872 (Acyl-coenzyme A oxidase), Q6DGF1 (Isocitrate dehydrogenase), Q9EQX9 (Ubiquitin-conjugating), Q63446 (Polyubiquitin), P24268 (Cathepsin D), Q91XW0 (Heat shock protein 86), Q5FVH0 (unknown), P58405 (Striatin 3), Q62667 (Major vault protein), Q66H50 (unknown), Q09167 (splicing factor), Q9JHU5 (Arfaptin 1)."|comment:"Insulin increased GLUT4 interaction with the following proteins:Q9Z1P2 (R-actinin-1), P45592 (Cofilin), Q9QXQ0 (R-actinin-4), P26473 (ADP-ribosylation factor), P26437 (ADP-ribosylation factor),   Q7TNP1 (Basigin 2), Q6P6R2 (Dihydrolipoamide dehydrogenase),   P04797 (GAPDH), Q63081 (Protein disulfide isomerase), P29457 (47 kDa heat shock protein), Q9R1J8 (Leprecan), O88638 (Putative eps protein),   Q64375 (Synaptonemal complex)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:NDPK - Interactions involving proteins containing InterPro domain IPR001564, Nucleoside diphosphate kinase, core.	taxid:10116(rat-l6)|taxid:10116(Rattus norvegicus)	-	2006/02/15	2021/11/30	rogid:PbFY2lfrty8yw40Jq7ShR7xfuV410116	rogid:Qdnhk7yvoFFYcRq5kEi7GQILaxs10116	intact-crc:44F3A2176D02515F|rigid:9RVm0UBcqQF4k06RGKO89Bg16Q8	false	myc tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P19357	uniprotkb:Q9Z1A6	intact:EBI-915426|uniprotkb:P97900|ensembl:ENSRNOP00000023256	intact:EBI-920261	psi-mi:glut4_rat(display_long)|uniprotkb:Glucose transporter type 4, insulin-responsive(gene name synonym)|uniprotkb:Slc2a4(gene name)|psi-mi:Slc2a4(display_short)|uniprotkb:Glut4(gene name synonym)	psi-mi:vigln_rat(display_long)|uniprotkb:Hdlbp(gene name)|psi-mi:Hdlbp(display_short)|uniprotkb:High density lipoprotein-binding protein(gene name synonym)|uniprotkb:Hbp(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Foster et al. (2006)	pubmed:16396496|mint:MINT-5218203	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-921030	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2711|refseq:NP_036883.1|refseq:XP_006246658.1|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007611"(learning or memory)|go:"GO:0007614"(short-term memory)|go:"GO:0007616"(long-term memory)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010021"(amylopectin biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031550"(positive regulation of brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044381"(glucose import in response to insulin stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046323"(glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0098694"(regulation of synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0098793"(presynapse)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002441("Glucose transporter, type 4 (GLUT4)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-189200|ensembl:ENSRNOG00000017226(gene)|ensembl:ENSRNOT00000023256(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)	interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|rgd:620962|go:"GO:0003729"(mRNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005844"(polysome)|go:"GO:0006869"(lipid transport)|go:"GO:0008203"(cholesterol metabolic process)|go:"GO:0034364"(high-density lipoprotein particle)|interpro:IPR036612|reactome:R-RNO-8964011	-	-	-	caution:"The participant EBI-349571(P68370) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919386(Q7TP47) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920972(Q5XIP9) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-916419(P11980) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919578(Q8R491) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920554(Q5U3Z7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920647(Q5U2X8) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920585(Q7TP24) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-779677(P05426) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-915744(P02454) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|agonist:Insulin was shown to increase or decrease GLUT4 protein interactions in specific cases.|comment:"Insulin decreased GLUT4 interactions with the following proteins: Q9ER30 (Sarcosin), P09527 (Rab-7), O88960 (N-ethylmaleimide sensitive), P09456 (PKA I regulatory subunit), P27881 (Hexokinase type II), P07872 (Acyl-coenzyme A oxidase), Q6DGF1 (Isocitrate dehydrogenase), Q9EQX9 (Ubiquitin-conjugating), Q63446 (Polyubiquitin), P24268 (Cathepsin D), Q91XW0 (Heat shock protein 86), Q5FVH0 (unknown), P58405 (Striatin 3), Q62667 (Major vault protein), Q66H50 (unknown), Q09167 (splicing factor), Q9JHU5 (Arfaptin 1)."|comment:"Insulin increased GLUT4 interaction with the following proteins:Q9Z1P2 (R-actinin-1), P45592 (Cofilin), Q9QXQ0 (R-actinin-4), P26473 (ADP-ribosylation factor), P26437 (ADP-ribosylation factor),   Q7TNP1 (Basigin 2), Q6P6R2 (Dihydrolipoamide dehydrogenase),   P04797 (GAPDH), Q63081 (Protein disulfide isomerase), P29457 (47 kDa heat shock protein), Q9R1J8 (Leprecan), O88638 (Putative eps protein),   Q64375 (Synaptonemal complex)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:NDPK - Interactions involving proteins containing InterPro domain IPR001564, Nucleoside diphosphate kinase, core.	taxid:10116(rat-l6)|taxid:10116(Rattus norvegicus)	-	2006/02/15	2021/11/30	rogid:PbFY2lfrty8yw40Jq7ShR7xfuV410116	rogid:hNjeEVrkVIK2HkvTXJh5DOB2R1U10116	intact-crc:44F3A2176D02515F|rigid:9RVm0UBcqQF4k06RGKO89Bg16Q8	false	myc tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P19357	uniprotkb:O55012	intact:EBI-915426|uniprotkb:P97900|ensembl:ENSRNOP00000023256	intact:EBI-915601|uniprotkb:O55011	psi-mi:glut4_rat(display_long)|uniprotkb:Glucose transporter type 4, insulin-responsive(gene name synonym)|uniprotkb:Slc2a4(gene name)|psi-mi:Slc2a4(display_short)|uniprotkb:Glut4(gene name synonym)	psi-mi:pical_rat(display_long)|uniprotkb:Clathrin assembly lymphoid myeloid leukemia protein(gene name synonym)|uniprotkb:Picalm(gene name)|psi-mi:Picalm(display_short)|uniprotkb:Calm(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Foster et al. (2006)	pubmed:16396496|mint:MINT-5218203	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-921030	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2711|refseq:NP_036883.1|refseq:XP_006246658.1|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007611"(learning or memory)|go:"GO:0007614"(short-term memory)|go:"GO:0007616"(long-term memory)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010021"(amylopectin biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031550"(positive regulation of brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044381"(glucose import in response to insulin stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046323"(glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0098694"(regulation of synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0098793"(presynapse)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002441("Glucose transporter, type 4 (GLUT4)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-189200|ensembl:ENSRNOG00000017226(gene)|ensembl:ENSRNOT00000023256(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)	reactome:R-RNO-9696264|interpro:IPR030412|rgd:621054|refseq:NP_446006.1|interpro:IPR011417(ANTH)|interpro:IPR014712(Clathrin adaptor, phosphoinositide-binding, GAT-like)|interpro:IPR008942(ENTH/VHS)|interpro:IPR013809(Epsin-like, N-terminal)|rcsb pdb:1HF8|rcsb pdb:1HFA|rcsb pdb:1HG2|rcsb pdb:1HG5|rcsb pdb:3ZYK|rcsb pdb:3ZYL|rcsb pdb:3ZYM|reactome:R-RNO-432722|reactome:R-RNO-8856825|reactome:R-RNO-8856828|go:"GO:0000149"(SNARE binding)|go:"GO:0005545"(1-phosphatidylinositol binding)|go:"GO:0005546"(phosphatidylinositol-4,5-bisphosphate binding)|go:"GO:0005634"(nucleus)|go:"GO:0005768"(endosome)|go:"GO:0005769"(early endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0006897"(endocytosis)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0006900"(vesicle budding from membrane)|go:"GO:0007409"(axonogenesis)|go:"GO:0007611"(learning or memory)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0009986"(cell surface)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016185"(synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0016188"(synaptic vesicle maturation)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0016197"(endosomal transport)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0030097"(hemopoiesis)|go:"GO:0030100"(regulation of endocytosis)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030276"(clathrin binding)|go:"GO:0031224"(intrinsic component of membrane)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031623"(receptor internalization)|go:"GO:0031982"(vesicle)|go:"GO:0032050"(clathrin heavy chain binding)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0035459"(vesicle cargo loading)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0048156"(tau protein binding)|go:"GO:0048261"(negative regulation of receptor-mediated endocytosis)|go:"GO:0048268"(clathrin coat assembly)|go:"GO:0048488"(synaptic vesicle endocytosis)|go:"GO:0048813"(dendrite morphogenesis)|go:"GO:0050750"(low-density lipoprotein particle receptor binding)|go:"GO:0050772"(positive regulation of axonogenesis)|go:"GO:0051223"(regulation of protein transport)|go:"GO:0055072"(iron ion homeostasis)|go:"GO:0070381"(endosome to plasma membrane transport vesicle)|go:"GO:0072583"(clathrin-dependent endocytosis)|go:"GO:0090647"(modulation of age-related behavioral decline)|go:"GO:0097418"(neurofibrillary tangle)|go:"GO:0097494"(regulation of vesicle size)|go:"GO:0097753"(membrane bending)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098688"(parallel fiber to Purkinje cell synapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098894"(extrinsic component of presynaptic endocytic zone membrane)|go:"GO:0150093"(amyloid-beta clearance by transcytosis)|go:"GO:1900242"(regulation of synaptic vesicle endocytosis)|go:"GO:1900244"(positive regulation of synaptic vesicle endocytosis)|go:"GO:1901216"(positive regulation of neuron death)|go:"GO:1902004"(positive regulation of amyloid-beta formation)|go:"GO:1902803"(regulation of synaptic vesicle transport)|go:"GO:1902959"(regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process)|go:"GO:1902961"(positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process)|go:"GO:1902963"(negative regulation of metalloendopeptidase activity involved in amyloid precursor protein catabolic process)|go:"GO:1903077"(negative regulation of protein localization to plasma membrane)|go:"GO:1903861"(positive regulation of dendrite extension)|go:"GO:1905224"(clathrin-coated pit assembly)|go:"GO:2000009"(negative regulation of protein localization to cell surface)|go:"GO:2000331"(regulation of terminal button organization)|go:"GO:2000809"(positive regulation of synaptic vesicle clustering)	-	-	-	caution:"The participant EBI-349571(P68370) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919386(Q7TP47) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920972(Q5XIP9) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-916419(P11980) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919578(Q8R491) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920554(Q5U3Z7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920647(Q5U2X8) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920585(Q7TP24) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-779677(P05426) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-915744(P02454) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|agonist:Insulin was shown to increase or decrease GLUT4 protein interactions in specific cases.|comment:"Insulin decreased GLUT4 interactions with the following proteins: Q9ER30 (Sarcosin), P09527 (Rab-7), O88960 (N-ethylmaleimide sensitive), P09456 (PKA I regulatory subunit), P27881 (Hexokinase type II), P07872 (Acyl-coenzyme A oxidase), Q6DGF1 (Isocitrate dehydrogenase), Q9EQX9 (Ubiquitin-conjugating), Q63446 (Polyubiquitin), P24268 (Cathepsin D), Q91XW0 (Heat shock protein 86), Q5FVH0 (unknown), P58405 (Striatin 3), Q62667 (Major vault protein), Q66H50 (unknown), Q09167 (splicing factor), Q9JHU5 (Arfaptin 1)."|comment:"Insulin increased GLUT4 interaction with the following proteins:Q9Z1P2 (R-actinin-1), P45592 (Cofilin), Q9QXQ0 (R-actinin-4), P26473 (ADP-ribosylation factor), P26437 (ADP-ribosylation factor),   Q7TNP1 (Basigin 2), Q6P6R2 (Dihydrolipoamide dehydrogenase),   P04797 (GAPDH), Q63081 (Protein disulfide isomerase), P29457 (47 kDa heat shock protein), Q9R1J8 (Leprecan), O88638 (Putative eps protein),   Q64375 (Synaptonemal complex)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:NDPK - Interactions involving proteins containing InterPro domain IPR001564, Nucleoside diphosphate kinase, core.	taxid:10116(rat-l6)|taxid:10116(Rattus norvegicus)	-	2006/02/15	2021/11/30	rogid:PbFY2lfrty8yw40Jq7ShR7xfuV410116	rogid:/j6nbgvmHpmdZRElkGR5+qlUInI10116	intact-crc:44F3A2176D02515F|rigid:9RVm0UBcqQF4k06RGKO89Bg16Q8	false	myc tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P19357	uniprotkb:Q5I0E7	intact:EBI-915426|uniprotkb:P97900|ensembl:ENSRNOP00000023256	intact:EBI-920903|ensembl:ENSRNOP00000030668	psi-mi:glut4_rat(display_long)|uniprotkb:Glucose transporter type 4, insulin-responsive(gene name synonym)|uniprotkb:Slc2a4(gene name)|psi-mi:Slc2a4(display_short)|uniprotkb:Glut4(gene name synonym)	psi-mi:tmed9_rat(display_long)|uniprotkb:Tmed9(gene name)|psi-mi:Tmed9(display_short)|uniprotkb:p24 family protein alpha-2(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Foster et al. (2006)	pubmed:16396496|mint:MINT-5218203	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-921030	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2711|refseq:NP_036883.1|refseq:XP_006246658.1|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007611"(learning or memory)|go:"GO:0007614"(short-term memory)|go:"GO:0007616"(long-term memory)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010021"(amylopectin biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031550"(positive regulation of brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044381"(glucose import in response to insulin stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046323"(glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0098694"(regulation of synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0098793"(presynapse)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002441("Glucose transporter, type 4 (GLUT4)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-189200|ensembl:ENSRNOG00000017226(gene)|ensembl:ENSRNOT00000023256(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)	rgd:1307627|refseq:NP_001009703.1|ensembl:ENSRNOG00000021882(gene)|ensembl:ENSRNOT00000036140(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005793"(endoplasmic reticulum-Golgi intermediate compartment)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006888"(endoplasmic reticulum to Golgi vesicle-mediated transport)|go:"GO:0007030"(Golgi organization)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0010638"(positive regulation of organelle organization)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019905"(syntaxin binding)|go:"GO:0030134"(COPII-coated ER to Golgi transport vesicle)|go:"GO:0033116"(endoplasmic reticulum-Golgi intermediate compartment membrane)|go:"GO:0048205"(COPI coating of Golgi vesicle)|interpro:IPR009038(GOLD)|interpro:IPR015720(TMP21 related)|reactome:R-RNO-6807878|reactome:R-RNO-6811434	-	-	-	caution:"The participant EBI-349571(P68370) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919386(Q7TP47) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920972(Q5XIP9) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-916419(P11980) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919578(Q8R491) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920554(Q5U3Z7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920647(Q5U2X8) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920585(Q7TP24) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-779677(P05426) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-915744(P02454) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|agonist:Insulin was shown to increase or decrease GLUT4 protein interactions in specific cases.|comment:"Insulin decreased GLUT4 interactions with the following proteins: Q9ER30 (Sarcosin), P09527 (Rab-7), O88960 (N-ethylmaleimide sensitive), P09456 (PKA I regulatory subunit), P27881 (Hexokinase type II), P07872 (Acyl-coenzyme A oxidase), Q6DGF1 (Isocitrate dehydrogenase), Q9EQX9 (Ubiquitin-conjugating), Q63446 (Polyubiquitin), P24268 (Cathepsin D), Q91XW0 (Heat shock protein 86), Q5FVH0 (unknown), P58405 (Striatin 3), Q62667 (Major vault protein), Q66H50 (unknown), Q09167 (splicing factor), Q9JHU5 (Arfaptin 1)."|comment:"Insulin increased GLUT4 interaction with the following proteins:Q9Z1P2 (R-actinin-1), P45592 (Cofilin), Q9QXQ0 (R-actinin-4), P26473 (ADP-ribosylation factor), P26437 (ADP-ribosylation factor),   Q7TNP1 (Basigin 2), Q6P6R2 (Dihydrolipoamide dehydrogenase),   P04797 (GAPDH), Q63081 (Protein disulfide isomerase), P29457 (47 kDa heat shock protein), Q9R1J8 (Leprecan), O88638 (Putative eps protein),   Q64375 (Synaptonemal complex)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:NDPK - Interactions involving proteins containing InterPro domain IPR001564, Nucleoside diphosphate kinase, core.	taxid:10116(rat-l6)|taxid:10116(Rattus norvegicus)	-	2006/02/15	2021/11/30	rogid:PbFY2lfrty8yw40Jq7ShR7xfuV410116	rogid:y2MZlmFDlsBrKuQONvsXuPHG4HE10116	intact-crc:44F3A2176D02515F|rigid:9RVm0UBcqQF4k06RGKO89Bg16Q8	false	myc tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P19357	uniprotkb:Q64428	intact:EBI-915426|uniprotkb:P97900|ensembl:ENSRNOP00000023256	intact:EBI-299533|ensembl:ENSRNOP00000038073|uniprotkb:Q5BIZ5	psi-mi:glut4_rat(display_long)|uniprotkb:Glucose transporter type 4, insulin-responsive(gene name synonym)|uniprotkb:Slc2a4(gene name)|psi-mi:Slc2a4(display_short)|uniprotkb:Glut4(gene name synonym)	psi-mi:echa_rat(display_long)|uniprotkb:Hadha(gene name)|psi-mi:Hadha(display_short)|uniprotkb:TP-alpha(gene name synonym)|uniprotkb:Monolysocardiolipin acyltransferase(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Foster et al. (2006)	pubmed:16396496|mint:MINT-5218203	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-921030	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2711|refseq:NP_036883.1|refseq:XP_006246658.1|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007611"(learning or memory)|go:"GO:0007614"(short-term memory)|go:"GO:0007616"(long-term memory)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010021"(amylopectin biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031550"(positive regulation of brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044381"(glucose import in response to insulin stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046323"(glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0098694"(regulation of synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0098793"(presynapse)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002441("Glucose transporter, type 4 (GLUT4)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-189200|ensembl:ENSRNOG00000017226(gene)|ensembl:ENSRNOT00000023256(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)	ensembl:ENSRNOG00000024629(gene)|ensembl:ENSRNOT00000038649(transcript)|go:"GO:0000062"(fatty-acyl-CoA binding)|go:"GO:0003857"(3-hydroxyacyl-CoA dehydrogenase activity)|go:"GO:0003988"(acetyl-CoA C-acyltransferase activity)|go:"GO:0004300"(enoyl-CoA hydratase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0016507"(mitochondrial fatty acid beta-oxidation multienzyme complex)|go:"GO:0016508"(long-chain-enoyl-CoA hydratase activity)|go:"GO:0016509"(long-chain-3-hydroxyacyl-CoA dehydrogenase activity)|go:"GO:0032868"(response to insulin)|go:"GO:0006635"(fatty acid beta-oxidation)|go:"GO:0035965"(cardiolipin acyl-chain remodeling)|go:"GO:0042493"|go:"GO:0042645"(mitochondrial nucleoid)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0051287"(NAD binding)|go:"GO:0070403"(NAD+ binding)|interpro:IPR001753(Crotonase, core)|interpro:IPR006108(3-hydroxyacyl-CoA dehydrogenase, C-terminal)|interpro:IPR006176(3-hydroxyacyl-CoA dehydrogenase, NAD binding)|interpro:IPR006180(3-hydroxyacyl-CoA dehydrogenase, conserved site)|interpro:IPR008927(6-phosphogluconate dehydrogenase, C-terminal-like)|interpro:IPR012803(Fatty acid oxidation complex, alpha subunit, mitochondrial)|interpro:IPR018376|interpro:IPR029045|interpro:IPR036291|mint:Q64428|reactome:R-RNO-1482798|reactome:R-RNO-77285|reactome:R-RNO-77305|reactome:R-RNO-77310|reactome:R-RNO-77346|reactome:R-RNO-77348|reactome:R-RNO-77350|rgd:620512|refseq:NP_570839.2	-	-	-	caution:"The participant EBI-349571(P68370) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919386(Q7TP47) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920972(Q5XIP9) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-916419(P11980) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919578(Q8R491) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920554(Q5U3Z7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920647(Q5U2X8) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920585(Q7TP24) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-779677(P05426) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-915744(P02454) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|agonist:Insulin was shown to increase or decrease GLUT4 protein interactions in specific cases.|comment:"Insulin decreased GLUT4 interactions with the following proteins: Q9ER30 (Sarcosin), P09527 (Rab-7), O88960 (N-ethylmaleimide sensitive), P09456 (PKA I regulatory subunit), P27881 (Hexokinase type II), P07872 (Acyl-coenzyme A oxidase), Q6DGF1 (Isocitrate dehydrogenase), Q9EQX9 (Ubiquitin-conjugating), Q63446 (Polyubiquitin), P24268 (Cathepsin D), Q91XW0 (Heat shock protein 86), Q5FVH0 (unknown), P58405 (Striatin 3), Q62667 (Major vault protein), Q66H50 (unknown), Q09167 (splicing factor), Q9JHU5 (Arfaptin 1)."|comment:"Insulin increased GLUT4 interaction with the following proteins:Q9Z1P2 (R-actinin-1), P45592 (Cofilin), Q9QXQ0 (R-actinin-4), P26473 (ADP-ribosylation factor), P26437 (ADP-ribosylation factor),   Q7TNP1 (Basigin 2), Q6P6R2 (Dihydrolipoamide dehydrogenase),   P04797 (GAPDH), Q63081 (Protein disulfide isomerase), P29457 (47 kDa heat shock protein), Q9R1J8 (Leprecan), O88638 (Putative eps protein),   Q64375 (Synaptonemal complex)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:NDPK - Interactions involving proteins containing InterPro domain IPR001564, Nucleoside diphosphate kinase, core.	taxid:10116(rat-l6)|taxid:10116(Rattus norvegicus)	-	2006/02/15	2021/11/30	rogid:PbFY2lfrty8yw40Jq7ShR7xfuV410116	rogid:29/8oipQMyGrNmdN1GK1cIzyNFU10116	intact-crc:44F3A2176D02515F|rigid:9RVm0UBcqQF4k06RGKO89Bg16Q8	false	myc tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P19357	uniprotkb:Q63524	intact:EBI-915426|uniprotkb:P97900|ensembl:ENSRNOP00000023256	intact:EBI-918600|ensembl:ENSRNOP00000001397	psi-mi:glut4_rat(display_long)|uniprotkb:Glucose transporter type 4, insulin-responsive(gene name synonym)|uniprotkb:Slc2a4(gene name)|psi-mi:Slc2a4(display_short)|uniprotkb:Glut4(gene name synonym)	psi-mi:tmed2_rat(display_long)|uniprotkb:RNP21.4(gene name synonym)|uniprotkb:Tmed2(gene name)|psi-mi:Tmed2(display_short)|uniprotkb:Rnp24(gene name synonym)|uniprotkb:Membrane protein p24A(gene name synonym)|uniprotkb:p24 family protein beta-1(gene name synonym)|uniprotkb:COPI-coated vesicle membrane protein p24(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Foster et al. (2006)	pubmed:16396496|mint:MINT-5218203	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-921030	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2711|refseq:NP_036883.1|refseq:XP_006246658.1|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007611"(learning or memory)|go:"GO:0007614"(short-term memory)|go:"GO:0007616"(long-term memory)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010021"(amylopectin biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031550"(positive regulation of brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044381"(glucose import in response to insulin stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046323"(glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0098694"(regulation of synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0098793"(presynapse)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002441("Glucose transporter, type 4 (GLUT4)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-189200|ensembl:ENSRNOG00000017226(gene)|ensembl:ENSRNOT00000023256(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)	rgd:69243|refseq:NP_113910.1|go:"GO:0007029"(endoplasmic reticulum organization)|go:"GO:0007030"(Golgi organization)|go:"GO:0008104"(protein localization)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030134"(COPII-coated ER to Golgi transport vesicle)|go:"GO:0030137"(COPI-coated vesicle)|go:"GO:0030663"(COPI-coated vesicle membrane)|go:"GO:0032525"(somite rostral/caudal axis specification)|go:"GO:0032580"(Golgi cisterna membrane)|go:"GO:0033116"(endoplasmic reticulum-Golgi intermediate compartment membrane)|go:"GO:0034260"(negative regulation of GTPase activity)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0036342"(post-anal tail morphogenesis)|go:"GO:0036499"(PERK-mediated unfolded protein response)|go:"GO:0042589"(zymogen granule membrane)|go:"GO:0048598"(embryonic morphogenesis)|go:"GO:0060670"(branching involved in labyrinthine layer morphogenesis)|go:"GO:0060716"(labyrinthine layer blood vessel development)|go:"GO:0060717"(chorion development)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0090158"(endoplasmic reticulum membrane organization)|go:"GO:1903912"(negative regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation)|go:"GO:1905069"(allantois development)|go:"GO:2000638"(regulation of SREBP signaling pathway)|interpro:IPR009038(GOLD)|interpro:IPR015720(TMP21 related)|interpro:IPR036598|reactome:R-RNO-1912420|reactome:R-RNO-204005|reactome:R-RNO-5694530|reactome:R-RNO-6807878|reactome:R-RNO-6811434|ensembl:ENSRNOG00000001053(gene)|ensembl:ENSRNOT00000001397(transcript)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001756"(somitogenesis)|go:"GO:0001843"(neural tube closure)|go:"GO:0001892"(embryonic placenta development)|go:"GO:0001893"(maternal placenta development)|go:"GO:0001947"(heart looping)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005793"(endoplasmic reticulum-Golgi intermediate compartment)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006888"(endoplasmic reticulum to Golgi vesicle-mediated transport)|go:"GO:0006903"(vesicle targeting)	-	-	-	caution:"The participant EBI-349571(P68370) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919386(Q7TP47) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920972(Q5XIP9) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-916419(P11980) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919578(Q8R491) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920554(Q5U3Z7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920647(Q5U2X8) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920585(Q7TP24) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-779677(P05426) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-915744(P02454) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|agonist:Insulin was shown to increase or decrease GLUT4 protein interactions in specific cases.|comment:"Insulin decreased GLUT4 interactions with the following proteins: Q9ER30 (Sarcosin), P09527 (Rab-7), O88960 (N-ethylmaleimide sensitive), P09456 (PKA I regulatory subunit), P27881 (Hexokinase type II), P07872 (Acyl-coenzyme A oxidase), Q6DGF1 (Isocitrate dehydrogenase), Q9EQX9 (Ubiquitin-conjugating), Q63446 (Polyubiquitin), P24268 (Cathepsin D), Q91XW0 (Heat shock protein 86), Q5FVH0 (unknown), P58405 (Striatin 3), Q62667 (Major vault protein), Q66H50 (unknown), Q09167 (splicing factor), Q9JHU5 (Arfaptin 1)."|comment:"Insulin increased GLUT4 interaction with the following proteins:Q9Z1P2 (R-actinin-1), P45592 (Cofilin), Q9QXQ0 (R-actinin-4), P26473 (ADP-ribosylation factor), P26437 (ADP-ribosylation factor),   Q7TNP1 (Basigin 2), Q6P6R2 (Dihydrolipoamide dehydrogenase),   P04797 (GAPDH), Q63081 (Protein disulfide isomerase), P29457 (47 kDa heat shock protein), Q9R1J8 (Leprecan), O88638 (Putative eps protein),   Q64375 (Synaptonemal complex)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:NDPK - Interactions involving proteins containing InterPro domain IPR001564, Nucleoside diphosphate kinase, core.	taxid:10116(rat-l6)|taxid:10116(Rattus norvegicus)	-	2006/02/15	2021/11/30	rogid:PbFY2lfrty8yw40Jq7ShR7xfuV410116	rogid:AkWi3UzhfnHE9tYW4/BJzXratrk10116	intact-crc:44F3A2176D02515F|rigid:9RVm0UBcqQF4k06RGKO89Bg16Q8	false	myc tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P19357	uniprotkb:Q2PS20	intact:EBI-915426|uniprotkb:P97900|ensembl:ENSRNOP00000023256	intact:EBI-920772|ensembl:ENSRNOP00000010938	psi-mi:glut4_rat(display_long)|uniprotkb:Glucose transporter type 4, insulin-responsive(gene name synonym)|uniprotkb:Slc2a4(gene name)|psi-mi:Slc2a4(display_short)|uniprotkb:Glut4(gene name synonym)	psi-mi:jph2_rat(display_long)|uniprotkb:Junctophilin type 2(gene name synonym)|uniprotkb:Jph2(gene name)|psi-mi:Jph2(display_short)|uniprotkb:Jp2(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Foster et al. (2006)	pubmed:16396496|mint:MINT-5218203	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-921030	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2711|refseq:NP_036883.1|refseq:XP_006246658.1|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007611"(learning or memory)|go:"GO:0007614"(short-term memory)|go:"GO:0007616"(long-term memory)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010021"(amylopectin biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031550"(positive regulation of brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044381"(glucose import in response to insulin stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046323"(glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0098694"(regulation of synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0098793"(presynapse)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002441("Glucose transporter, type 4 (GLUT4)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-189200|ensembl:ENSRNOG00000017226(gene)|ensembl:ENSRNOT00000023256(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)	rgd:1305196|refseq:NP_001033063.1|refseq:XP_006235588.1|ensembl:ENSRNOG00000008170(gene)|ensembl:ENSRNOT00000010939(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001046"(core promoter sequence-specific DNA binding)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0001786"(phosphatidylserine binding)|go:"GO:0005546"(phosphatidylinositol-4,5-bisphosphate binding)|go:"GO:0005547"(phosphatidylinositol-3,4,5-trisphosphate binding)|go:"GO:0005634"(nucleus)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0010314"(phosphatidylinositol-5-phosphate binding)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030018"(Z disc)|go:"GO:0030314"(junctional membrane complex)|go:"GO:0032266"(phosphatidylinositol-3-phosphate binding)|go:"GO:0033017"(sarcoplasmic reticulum membrane)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0055024"(regulation of cardiac muscle tissue development)|go:"GO:0055074"(calcium ion homeostasis)|go:"GO:0060316"(positive regulation of ryanodine-sensitive calcium-release channel activity)|go:"GO:0070273"(phosphatidylinositol-4-phosphate binding)|go:"GO:0070300"(phosphatidic acid binding)|go:"GO:0080025"(phosphatidylinositol-3,5-bisphosphate binding)|interpro:IPR003409(MORN motif)|interpro:IPR017191(Junctophilin)	-	-	-	caution:"The participant EBI-349571(P68370) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919386(Q7TP47) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920972(Q5XIP9) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-916419(P11980) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919578(Q8R491) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920554(Q5U3Z7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920647(Q5U2X8) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920585(Q7TP24) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-779677(P05426) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-915744(P02454) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|agonist:Insulin was shown to increase or decrease GLUT4 protein interactions in specific cases.|comment:"Insulin decreased GLUT4 interactions with the following proteins: Q9ER30 (Sarcosin), P09527 (Rab-7), O88960 (N-ethylmaleimide sensitive), P09456 (PKA I regulatory subunit), P27881 (Hexokinase type II), P07872 (Acyl-coenzyme A oxidase), Q6DGF1 (Isocitrate dehydrogenase), Q9EQX9 (Ubiquitin-conjugating), Q63446 (Polyubiquitin), P24268 (Cathepsin D), Q91XW0 (Heat shock protein 86), Q5FVH0 (unknown), P58405 (Striatin 3), Q62667 (Major vault protein), Q66H50 (unknown), Q09167 (splicing factor), Q9JHU5 (Arfaptin 1)."|comment:"Insulin increased GLUT4 interaction with the following proteins:Q9Z1P2 (R-actinin-1), P45592 (Cofilin), Q9QXQ0 (R-actinin-4), P26473 (ADP-ribosylation factor), P26437 (ADP-ribosylation factor),   Q7TNP1 (Basigin 2), Q6P6R2 (Dihydrolipoamide dehydrogenase),   P04797 (GAPDH), Q63081 (Protein disulfide isomerase), P29457 (47 kDa heat shock protein), Q9R1J8 (Leprecan), O88638 (Putative eps protein),   Q64375 (Synaptonemal complex)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:NDPK - Interactions involving proteins containing InterPro domain IPR001564, Nucleoside diphosphate kinase, core.	taxid:10116(rat-l6)|taxid:10116(Rattus norvegicus)	-	2006/02/15	2021/11/30	rogid:PbFY2lfrty8yw40Jq7ShR7xfuV410116	rogid:apKBpIYBZU2b8QRoq6Og+xCmQwg10116	intact-crc:44F3A2176D02515F|rigid:9RVm0UBcqQF4k06RGKO89Bg16Q8	false	myc tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P19357	uniprotkb:O70257	intact:EBI-915426|uniprotkb:P97900|ensembl:ENSRNOP00000023256	intact:EBI-915626|uniprotkb:Q5U337|ensembl:ENSRNOP00000021318	psi-mi:glut4_rat(display_long)|uniprotkb:Glucose transporter type 4, insulin-responsive(gene name synonym)|uniprotkb:Slc2a4(gene name)|psi-mi:Slc2a4(display_short)|uniprotkb:Glut4(gene name synonym)	psi-mi:stx7_rat(display_long)|uniprotkb:Stx7(gene name)|psi-mi:Stx7(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Foster et al. (2006)	pubmed:16396496|mint:MINT-5218203	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-921030	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2711|refseq:NP_036883.1|refseq:XP_006246658.1|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007611"(learning or memory)|go:"GO:0007614"(short-term memory)|go:"GO:0007616"(long-term memory)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010021"(amylopectin biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031550"(positive regulation of brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044381"(glucose import in response to insulin stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046323"(glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0098694"(regulation of synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0098793"(presynapse)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002441("Glucose transporter, type 4 (GLUT4)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-189200|ensembl:ENSRNOG00000017226(gene)|ensembl:ENSRNOT00000023256(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)	rgd:619747|refseq:NP_068641.2|refseq:XP_017445133.1|refseq:XP_017445134.1|refseq:XP_017445135.1|dip:DIP-37411N|ensembl:ENSRNOG00000015670(gene)|ensembl:ENSRNOT00000021318(transcript)|go:"GO:0000149"(SNARE binding)|go:"GO:0001772"(immunological synapse)|go:"GO:0001916"(positive regulation of T cell mediated cytotoxicity)|go:"GO:0005484"(SNAP receptor activity)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005768"(endosome)|go:"GO:0005769"(early endosome)|go:"GO:0005770"(late endosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006906"(vesicle fusion)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008333"(endosome to lysosome transport)|go:"GO:0012505"(endomembrane system)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016079"(synaptic vesicle exocytosis)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0019869"(chloride channel inhibitor activity)|go:"GO:0019905"(syntaxin binding)|go:"GO:0030139"(endocytic vesicle)|go:"GO:0030285"(integral component of synaptic vesicle membrane)|go:"GO:0031201"(SNARE complex)|go:"GO:0031901"(early endosome membrane)|go:"GO:0031902"(late endosome membrane)|go:"GO:0031982"(vesicle)|go:"GO:0042582"(azurophil granule)|go:"GO:0043195"(terminal bouton)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0048278"(vesicle docking)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051640"(organelle localization)|go:"GO:0055037"(recycling endosome)|go:"GO:0070820"(tertiary granule)|go:"GO:0070925"(organelle assembly)|go:"GO:1902685"(positive regulation of receptor localization to synapse)|go:"GO:1903076"(regulation of protein localization to plasma membrane)|interpro:IPR000727(Target SNARE coiled-coil region)|interpro:IPR006011(Syntaxin, N-terminal)|interpro:IPR006012(Syntaxin/epimorphin, conserved site)|interpro:IPR010989(t-SNARE)	-	-	-	caution:"The participant EBI-349571(P68370) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919386(Q7TP47) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920972(Q5XIP9) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-916419(P11980) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919578(Q8R491) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920554(Q5U3Z7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920647(Q5U2X8) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920585(Q7TP24) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-779677(P05426) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-915744(P02454) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|agonist:Insulin was shown to increase or decrease GLUT4 protein interactions in specific cases.|comment:"Insulin decreased GLUT4 interactions with the following proteins: Q9ER30 (Sarcosin), P09527 (Rab-7), O88960 (N-ethylmaleimide sensitive), P09456 (PKA I regulatory subunit), P27881 (Hexokinase type II), P07872 (Acyl-coenzyme A oxidase), Q6DGF1 (Isocitrate dehydrogenase), Q9EQX9 (Ubiquitin-conjugating), Q63446 (Polyubiquitin), P24268 (Cathepsin D), Q91XW0 (Heat shock protein 86), Q5FVH0 (unknown), P58405 (Striatin 3), Q62667 (Major vault protein), Q66H50 (unknown), Q09167 (splicing factor), Q9JHU5 (Arfaptin 1)."|comment:"Insulin increased GLUT4 interaction with the following proteins:Q9Z1P2 (R-actinin-1), P45592 (Cofilin), Q9QXQ0 (R-actinin-4), P26473 (ADP-ribosylation factor), P26437 (ADP-ribosylation factor),   Q7TNP1 (Basigin 2), Q6P6R2 (Dihydrolipoamide dehydrogenase),   P04797 (GAPDH), Q63081 (Protein disulfide isomerase), P29457 (47 kDa heat shock protein), Q9R1J8 (Leprecan), O88638 (Putative eps protein),   Q64375 (Synaptonemal complex)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:NDPK - Interactions involving proteins containing InterPro domain IPR001564, Nucleoside diphosphate kinase, core.	taxid:10116(rat-l6)|taxid:10116(Rattus norvegicus)	-	2006/02/15	2021/11/30	rogid:PbFY2lfrty8yw40Jq7ShR7xfuV410116	rogid:sBCR13fb2g7+T6GGrnzjY6S9j0A10116	intact-crc:44F3A2176D02515F|rigid:9RVm0UBcqQF4k06RGKO89Bg16Q8	false	myc tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P19357	uniprotkb:Q5XIA1	intact:EBI-915426|uniprotkb:P97900|ensembl:ENSRNOP00000023256	intact:EBI-920799	psi-mi:glut4_rat(display_long)|uniprotkb:Glucose transporter type 4, insulin-responsive(gene name synonym)|uniprotkb:Slc2a4(gene name)|psi-mi:Slc2a4(display_short)|uniprotkb:Glut4(gene name synonym)	psi-mi:ncln_rat(display_long)|uniprotkb:Ncln(gene name)|psi-mi:Ncln(display_short)|uniprotkb:Nicastrin-like protein(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Foster et al. (2006)	pubmed:16396496|mint:MINT-5218203	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-921030	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2711|refseq:NP_036883.1|refseq:XP_006246658.1|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007611"(learning or memory)|go:"GO:0007614"(short-term memory)|go:"GO:0007616"(long-term memory)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010021"(amylopectin biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031550"(positive regulation of brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044381"(glucose import in response to insulin stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046323"(glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0098694"(regulation of synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0098793"(presynapse)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002441("Glucose transporter, type 4 (GLUT4)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-189200|ensembl:ENSRNOG00000017226(gene)|ensembl:ENSRNOT00000023256(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)	rgd:1309355|refseq:NP_001014104.1|interpro:IPR016574(Nicalin)|interpro:IPR007484(Peptidase M28)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0008235"(metalloexopeptidase activity)|go:"GO:0009966"(regulation of signal transduction)|go:"GO:0016021"(integral component of membrane)|go:"GO:0032991"(protein-containing complex)|go:"GO:0043022"(ribosome binding)|go:"GO:0043254"(regulation of protein-containing complex assembly)|go:"GO:0050821"(protein stabilization)|go:"GO:0061635"(regulation of protein complex stability)	-	-	-	caution:"The participant EBI-349571(P68370) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919386(Q7TP47) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920972(Q5XIP9) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-916419(P11980) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919578(Q8R491) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920554(Q5U3Z7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920647(Q5U2X8) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920585(Q7TP24) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-779677(P05426) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-915744(P02454) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|agonist:Insulin was shown to increase or decrease GLUT4 protein interactions in specific cases.|comment:"Insulin decreased GLUT4 interactions with the following proteins: Q9ER30 (Sarcosin), P09527 (Rab-7), O88960 (N-ethylmaleimide sensitive), P09456 (PKA I regulatory subunit), P27881 (Hexokinase type II), P07872 (Acyl-coenzyme A oxidase), Q6DGF1 (Isocitrate dehydrogenase), Q9EQX9 (Ubiquitin-conjugating), Q63446 (Polyubiquitin), P24268 (Cathepsin D), Q91XW0 (Heat shock protein 86), Q5FVH0 (unknown), P58405 (Striatin 3), Q62667 (Major vault protein), Q66H50 (unknown), Q09167 (splicing factor), Q9JHU5 (Arfaptin 1)."|comment:"Insulin increased GLUT4 interaction with the following proteins:Q9Z1P2 (R-actinin-1), P45592 (Cofilin), Q9QXQ0 (R-actinin-4), P26473 (ADP-ribosylation factor), P26437 (ADP-ribosylation factor),   Q7TNP1 (Basigin 2), Q6P6R2 (Dihydrolipoamide dehydrogenase),   P04797 (GAPDH), Q63081 (Protein disulfide isomerase), P29457 (47 kDa heat shock protein), Q9R1J8 (Leprecan), O88638 (Putative eps protein),   Q64375 (Synaptonemal complex)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:NDPK - Interactions involving proteins containing InterPro domain IPR001564, Nucleoside diphosphate kinase, core.	taxid:10116(rat-l6)|taxid:10116(Rattus norvegicus)	-	2006/02/15	2021/11/30	rogid:PbFY2lfrty8yw40Jq7ShR7xfuV410116	rogid:gIT+hkYx1YU0YKnTTghVLJDjcZ410116	intact-crc:44F3A2176D02515F|rigid:9RVm0UBcqQF4k06RGKO89Bg16Q8	false	myc tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P19357	uniprotkb:P97700	intact:EBI-915426|uniprotkb:P97900|ensembl:ENSRNOP00000023256	intact:EBI-918109	psi-mi:glut4_rat(display_long)|uniprotkb:Glucose transporter type 4, insulin-responsive(gene name synonym)|uniprotkb:Slc2a4(gene name)|psi-mi:Slc2a4(display_short)|uniprotkb:Glut4(gene name synonym)	psi-mi:m2om_rat(display_long)|uniprotkb:Solute carrier family 25 member 11(gene name synonym)|uniprotkb:Slc25a11(gene name)|psi-mi:Slc25a11(display_short)|uniprotkb:Slc20a4(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Foster et al. (2006)	pubmed:16396496|mint:MINT-5218203	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-921030	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2711|refseq:NP_036883.1|refseq:XP_006246658.1|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007611"(learning or memory)|go:"GO:0007614"(short-term memory)|go:"GO:0007616"(long-term memory)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010021"(amylopectin biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031550"(positive regulation of brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044381"(glucose import in response to insulin stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046323"(glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0098694"(regulation of synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0098793"(presynapse)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002441("Glucose transporter, type 4 (GLUT4)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-189200|ensembl:ENSRNOG00000017226(gene)|ensembl:ENSRNOT00000023256(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)	rgd:708476|refseq:NP_071793.1|interpro:IPR018108|interpro:IPR023395|mint:P97700|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0008272"(sulfate transport)|go:"GO:0015116"(sulfate transmembrane transporter activity)|go:"GO:0015117"(thiosulfate transmembrane transporter activity)|go:"GO:0015131"(oxaloacetate transmembrane transporter activity)|go:"GO:0015139"(alpha-ketoglutarate transmembrane transporter activity)|go:"GO:0015140"(malate transmembrane transporter activity)|go:"GO:0015141"(succinate transmembrane transporter activity)|go:"GO:0015297"(antiporter activity)|go:"GO:0015709"(thiosulfate transport)|go:"GO:0015729"(oxaloacetate transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0035435"(phosphate ion transmembrane transport)|go:"GO:0071422"(succinate transmembrane transport)|go:"GO:0071423"(malate transmembrane transport)|reactome:R-RNO-70263	-	-	-	caution:"The participant EBI-349571(P68370) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919386(Q7TP47) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920972(Q5XIP9) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-916419(P11980) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919578(Q8R491) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920554(Q5U3Z7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920647(Q5U2X8) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920585(Q7TP24) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-779677(P05426) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-915744(P02454) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|agonist:Insulin was shown to increase or decrease GLUT4 protein interactions in specific cases.|comment:"Insulin decreased GLUT4 interactions with the following proteins: Q9ER30 (Sarcosin), P09527 (Rab-7), O88960 (N-ethylmaleimide sensitive), P09456 (PKA I regulatory subunit), P27881 (Hexokinase type II), P07872 (Acyl-coenzyme A oxidase), Q6DGF1 (Isocitrate dehydrogenase), Q9EQX9 (Ubiquitin-conjugating), Q63446 (Polyubiquitin), P24268 (Cathepsin D), Q91XW0 (Heat shock protein 86), Q5FVH0 (unknown), P58405 (Striatin 3), Q62667 (Major vault protein), Q66H50 (unknown), Q09167 (splicing factor), Q9JHU5 (Arfaptin 1)."|comment:"Insulin increased GLUT4 interaction with the following proteins:Q9Z1P2 (R-actinin-1), P45592 (Cofilin), Q9QXQ0 (R-actinin-4), P26473 (ADP-ribosylation factor), P26437 (ADP-ribosylation factor),   Q7TNP1 (Basigin 2), Q6P6R2 (Dihydrolipoamide dehydrogenase),   P04797 (GAPDH), Q63081 (Protein disulfide isomerase), P29457 (47 kDa heat shock protein), Q9R1J8 (Leprecan), O88638 (Putative eps protein),   Q64375 (Synaptonemal complex)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:NDPK - Interactions involving proteins containing InterPro domain IPR001564, Nucleoside diphosphate kinase, core.	taxid:10116(rat-l6)|taxid:10116(Rattus norvegicus)	-	2006/02/15	2021/11/30	rogid:PbFY2lfrty8yw40Jq7ShR7xfuV410116	rogid:CwkgqsG6PQ93hzzwLedusjml4do10116	intact-crc:44F3A2176D02515F|rigid:9RVm0UBcqQF4k06RGKO89Bg16Q8	false	myc tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P19357	uniprotkb:Q6NX65	intact:EBI-915426|uniprotkb:P97900|ensembl:ENSRNOP00000023256	intact:EBI-918908|ensembl:ENSRNOP00000013585	psi-mi:glut4_rat(display_long)|uniprotkb:Glucose transporter type 4, insulin-responsive(gene name synonym)|uniprotkb:Slc2a4(gene name)|psi-mi:Slc2a4(display_short)|uniprotkb:Glut4(gene name synonym)	psi-mi:pdc10_rat(display_long)|uniprotkb:Pdcd10(gene name)|psi-mi:Pdcd10(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Foster et al. (2006)	pubmed:16396496|mint:MINT-5218203	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-921030	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2711|refseq:NP_036883.1|refseq:XP_006246658.1|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007611"(learning or memory)|go:"GO:0007614"(short-term memory)|go:"GO:0007616"(long-term memory)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010021"(amylopectin biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031550"(positive regulation of brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044381"(glucose import in response to insulin stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046323"(glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0098694"(regulation of synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0098793"(presynapse)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002441("Glucose transporter, type 4 (GLUT4)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-189200|ensembl:ENSRNOG00000017226(gene)|ensembl:ENSRNOT00000023256(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)	rgd:1359329|refseq:NP_001009542.1|refseq:XP_006232563.1|ensembl:ENSRNOG00000010147(gene)|ensembl:ENSRNOT00000013585(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001525"(angiogenesis)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0032874"(positive regulation of stress-activated MAPK cascade)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0036481"(intrinsic apoptotic signaling pathway in response to hydrogen peroxide)|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0044319"(wound healing, spreading of cells)|go:"GO:0045747"(positive regulation of Notch signaling pathway)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0050821"(protein stabilization)|go:"GO:0051683"(establishment of Golgi localization)|go:"GO:0071902"(positive regulation of protein serine/threonine kinase activity)|go:"GO:0090051"(negative regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0090168"(Golgi reassembly)|go:"GO:0090316"(positive regulation of intracellular protein transport)|go:"GO:0090443"(FAR/SIN/STRIPAK complex)|go:"GO:1903358"(regulation of Golgi organization)|go:"GO:1903588"(negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis)|go:"GO:1990830"(cellular response to leukemia inhibitory factor)|interpro:IPR009652(Protein of unknown function DUF1241)	-	-	-	caution:"The participant EBI-349571(P68370) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919386(Q7TP47) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920972(Q5XIP9) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-916419(P11980) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919578(Q8R491) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920554(Q5U3Z7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920647(Q5U2X8) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920585(Q7TP24) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-779677(P05426) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-915744(P02454) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|agonist:Insulin was shown to increase or decrease GLUT4 protein interactions in specific cases.|comment:"Insulin decreased GLUT4 interactions with the following proteins: Q9ER30 (Sarcosin), P09527 (Rab-7), O88960 (N-ethylmaleimide sensitive), P09456 (PKA I regulatory subunit), P27881 (Hexokinase type II), P07872 (Acyl-coenzyme A oxidase), Q6DGF1 (Isocitrate dehydrogenase), Q9EQX9 (Ubiquitin-conjugating), Q63446 (Polyubiquitin), P24268 (Cathepsin D), Q91XW0 (Heat shock protein 86), Q5FVH0 (unknown), P58405 (Striatin 3), Q62667 (Major vault protein), Q66H50 (unknown), Q09167 (splicing factor), Q9JHU5 (Arfaptin 1)."|comment:"Insulin increased GLUT4 interaction with the following proteins:Q9Z1P2 (R-actinin-1), P45592 (Cofilin), Q9QXQ0 (R-actinin-4), P26473 (ADP-ribosylation factor), P26437 (ADP-ribosylation factor),   Q7TNP1 (Basigin 2), Q6P6R2 (Dihydrolipoamide dehydrogenase),   P04797 (GAPDH), Q63081 (Protein disulfide isomerase), P29457 (47 kDa heat shock protein), Q9R1J8 (Leprecan), O88638 (Putative eps protein),   Q64375 (Synaptonemal complex)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:NDPK - Interactions involving proteins containing InterPro domain IPR001564, Nucleoside diphosphate kinase, core.	taxid:10116(rat-l6)|taxid:10116(Rattus norvegicus)	-	2006/02/15	2021/11/30	rogid:PbFY2lfrty8yw40Jq7ShR7xfuV410116	rogid:lNJhtLUCLkq8mpy4I6D+ygxtcmY10116	intact-crc:44F3A2176D02515F|rigid:9RVm0UBcqQF4k06RGKO89Bg16Q8	false	myc tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P19357	uniprotkb:Q8R490	intact:EBI-915426|uniprotkb:P97900|ensembl:ENSRNOP00000023256	intact:EBI-919571|ensembl:ENSRNOP00000068368	psi-mi:glut4_rat(display_long)|uniprotkb:Glucose transporter type 4, insulin-responsive(gene name synonym)|uniprotkb:Slc2a4(gene name)|psi-mi:Slc2a4(display_short)|uniprotkb:Glut4(gene name synonym)	psi-mi:q8r490_rat(display_long)|uniprotkb:Cdh13(gene name)|psi-mi:Cdh13(display_short)|uniprotkb:rCG_51389(orf name)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Foster et al. (2006)	pubmed:16396496|mint:MINT-5218203	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-921030	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2711|refseq:NP_036883.1|refseq:XP_006246658.1|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007611"(learning or memory)|go:"GO:0007614"(short-term memory)|go:"GO:0007616"(long-term memory)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010021"(amylopectin biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031550"(positive regulation of brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044381"(glucose import in response to insulin stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046323"(glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0098694"(regulation of synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0098793"(presynapse)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002441("Glucose transporter, type 4 (GLUT4)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-189200|ensembl:ENSRNOG00000017226(gene)|ensembl:ENSRNOT00000023256(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)	rgd:619745|refseq:NP_620244.1|go:"GO:0030100"(regulation of endocytosis)|go:"GO:0030169"(low-density lipoprotein particle binding)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0031225"(anchored component of membrane)|go:"GO:0042058"(regulation of epidermal growth factor receptor signaling pathway)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043005"(neuron projection)|go:"GO:0043542"(endothelial cell migration)|go:"GO:0043616"(keratinocyte proliferation)|go:"GO:0045202"(synapse)|go:"GO:0045296"(cadherin binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0050850"(positive regulation of calcium-mediated signaling)|go:"GO:0050927"(positive regulation of positive chemotaxis)|go:"GO:0051668"(localization within membrane)|go:"GO:0055096"(low-density lipoprotein particle mediated signaling)|go:"GO:0055100"(adiponectin binding)|go:"GO:0071813"(lipoprotein particle binding)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0098742"(cell-cell adhesion via plasma-membrane adhesion molecules)|go:"GO:0098982"(GABA-ergic synapse)|interpro:IPR002126(Cadherin)|interpro:IPR014868(Cadherin prodomain like)|interpro:IPR015919(Cadherin-like)|interpro:IPR020894|interpro:IPR033216|interpro:IPR039808|reactome:R-RNO-418990|ensembl:ENSRNOG00000014371(gene)|ensembl:ENSRNOT00000077053(transcript)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0001954"(positive regulation of cell-matrix adhesion)|go:"GO:0002040"(sprouting angiogenesis)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0007156"(homophilic cell adhesion via plasma membrane adhesion molecules)|go:"GO:0007162"(negative regulation of cell adhesion)|go:"GO:0007266"(Rho protein signal transduction)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0010033"(response to organic substance)|go:"GO:0016339"(calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0016342"(catenin complex)|go:"GO:0016601"(Rac protein signal transduction)|go:"GO:0030032"(lamellipodium assembly)	-	-	-	caution:"The participant EBI-349571(P68370) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919386(Q7TP47) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920972(Q5XIP9) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-916419(P11980) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919578(Q8R491) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920554(Q5U3Z7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920647(Q5U2X8) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920585(Q7TP24) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-779677(P05426) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-915744(P02454) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|agonist:Insulin was shown to increase or decrease GLUT4 protein interactions in specific cases.|comment:"Insulin decreased GLUT4 interactions with the following proteins: Q9ER30 (Sarcosin), P09527 (Rab-7), O88960 (N-ethylmaleimide sensitive), P09456 (PKA I regulatory subunit), P27881 (Hexokinase type II), P07872 (Acyl-coenzyme A oxidase), Q6DGF1 (Isocitrate dehydrogenase), Q9EQX9 (Ubiquitin-conjugating), Q63446 (Polyubiquitin), P24268 (Cathepsin D), Q91XW0 (Heat shock protein 86), Q5FVH0 (unknown), P58405 (Striatin 3), Q62667 (Major vault protein), Q66H50 (unknown), Q09167 (splicing factor), Q9JHU5 (Arfaptin 1)."|comment:"Insulin increased GLUT4 interaction with the following proteins:Q9Z1P2 (R-actinin-1), P45592 (Cofilin), Q9QXQ0 (R-actinin-4), P26473 (ADP-ribosylation factor), P26437 (ADP-ribosylation factor),   Q7TNP1 (Basigin 2), Q6P6R2 (Dihydrolipoamide dehydrogenase),   P04797 (GAPDH), Q63081 (Protein disulfide isomerase), P29457 (47 kDa heat shock protein), Q9R1J8 (Leprecan), O88638 (Putative eps protein),   Q64375 (Synaptonemal complex)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:NDPK - Interactions involving proteins containing InterPro domain IPR001564, Nucleoside diphosphate kinase, core.	taxid:10116(rat-l6)|taxid:10116(Rattus norvegicus)	-	2006/02/15	2021/11/30	rogid:PbFY2lfrty8yw40Jq7ShR7xfuV410116	rogid:vc35jf+Anpv3uWT+j6E8NvJ7tpw10116	intact-crc:44F3A2176D02515F|rigid:9RVm0UBcqQF4k06RGKO89Bg16Q8	false	myc tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P19357	uniprotkb:P13264	intact:EBI-915426|uniprotkb:P97900|ensembl:ENSRNOP00000023256	intact:EBI-919564|uniprotkb:Q8R421	psi-mi:glut4_rat(display_long)|uniprotkb:Glucose transporter type 4, insulin-responsive(gene name synonym)|uniprotkb:Slc2a4(gene name)|psi-mi:Slc2a4(display_short)|uniprotkb:Glut4(gene name synonym)	psi-mi:glsk_rat(display_long)|uniprotkb:Gls(gene name)|psi-mi:Gls(display_short)|uniprotkb:K-glutaminase(gene name synonym)|uniprotkb:L-glutamine amidohydrolase(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Foster et al. (2006)	pubmed:16396496|mint:MINT-5218203	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-921030	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2711|refseq:NP_036883.1|refseq:XP_006246658.1|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007611"(learning or memory)|go:"GO:0007614"(short-term memory)|go:"GO:0007616"(long-term memory)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010021"(amylopectin biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031550"(positive regulation of brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044381"(glucose import in response to insulin stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046323"(glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0098694"(regulation of synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0098793"(presynapse)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002441("Glucose transporter, type 4 (GLUT4)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-189200|ensembl:ENSRNOG00000017226(gene)|ensembl:ENSRNOT00000023256(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)	rgd:2707|refseq:NP_001103438.1|refseq:NP_036701.2|dip:DIP-60007N|reactome:R-RNO-210500|reactome:R-RNO-5628897|reactome:R-RNO-8964539|go:"GO:0001967"(suckling behavior)|go:"GO:0002087"(regulation of respiratory gaseous exchange by nervous system process)|go:"GO:0004359"(glutaminase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005829"(cytosol)|go:"GO:0006537"(glutamate biosynthetic process)|go:"GO:0006543"(glutamine catabolic process)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0042802"(identical protein binding)|go:"GO:0045202"(synapse)|go:"GO:0051289"(protein homotetramerization)|go:"GO:0090461"(glutamate homeostasis)|interpro:IPR002110(Ankyrin)|interpro:IPR012338(Beta-lactamase-type transpeptidase fold)|interpro:IPR015868(Glutaminase, core)|interpro:IPR020683|interpro:IPR036770|interpro:IPR041541	-	-	-	caution:"The participant EBI-349571(P68370) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919386(Q7TP47) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920972(Q5XIP9) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-916419(P11980) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919578(Q8R491) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920554(Q5U3Z7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920647(Q5U2X8) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920585(Q7TP24) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-779677(P05426) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-915744(P02454) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|agonist:Insulin was shown to increase or decrease GLUT4 protein interactions in specific cases.|comment:"Insulin decreased GLUT4 interactions with the following proteins: Q9ER30 (Sarcosin), P09527 (Rab-7), O88960 (N-ethylmaleimide sensitive), P09456 (PKA I regulatory subunit), P27881 (Hexokinase type II), P07872 (Acyl-coenzyme A oxidase), Q6DGF1 (Isocitrate dehydrogenase), Q9EQX9 (Ubiquitin-conjugating), Q63446 (Polyubiquitin), P24268 (Cathepsin D), Q91XW0 (Heat shock protein 86), Q5FVH0 (unknown), P58405 (Striatin 3), Q62667 (Major vault protein), Q66H50 (unknown), Q09167 (splicing factor), Q9JHU5 (Arfaptin 1)."|comment:"Insulin increased GLUT4 interaction with the following proteins:Q9Z1P2 (R-actinin-1), P45592 (Cofilin), Q9QXQ0 (R-actinin-4), P26473 (ADP-ribosylation factor), P26437 (ADP-ribosylation factor),   Q7TNP1 (Basigin 2), Q6P6R2 (Dihydrolipoamide dehydrogenase),   P04797 (GAPDH), Q63081 (Protein disulfide isomerase), P29457 (47 kDa heat shock protein), Q9R1J8 (Leprecan), O88638 (Putative eps protein),   Q64375 (Synaptonemal complex)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:NDPK - Interactions involving proteins containing InterPro domain IPR001564, Nucleoside diphosphate kinase, core.	taxid:10116(rat-l6)|taxid:10116(Rattus norvegicus)	-	2006/02/15	2021/11/30	rogid:PbFY2lfrty8yw40Jq7ShR7xfuV410116	rogid:JtsFNDG+EredOepnqhC73CMQl2M10116	intact-crc:44F3A2176D02515F|rigid:9RVm0UBcqQF4k06RGKO89Bg16Q8	false	myc tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P19357	uniprotkb:Q8R3Z7	intact:EBI-915426|uniprotkb:P97900|ensembl:ENSRNOP00000023256	intact:EBI-919553|intact:EBI-11702609|ensembl:ENSRNOP00000010701	psi-mi:glut4_rat(display_long)|uniprotkb:Glucose transporter type 4, insulin-responsive(gene name synonym)|uniprotkb:Slc2a4(gene name)|psi-mi:Slc2a4(display_short)|uniprotkb:Glut4(gene name synonym)	psi-mi:q8r3z7_rat(display_long)|uniprotkb:Ehd4(gene name)|psi-mi:Ehd4(display_short)|uniprotkb:rCG_26704(orf name)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Foster et al. (2006)	pubmed:16396496|mint:MINT-5218203	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-921030	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2711|refseq:NP_036883.1|refseq:XP_006246658.1|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007611"(learning or memory)|go:"GO:0007614"(short-term memory)|go:"GO:0007616"(long-term memory)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010021"(amylopectin biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031550"(positive regulation of brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044381"(glucose import in response to insulin stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046323"(glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0098694"(regulation of synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0098793"(presynapse)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002441("Glucose transporter, type 4 (GLUT4)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-189200|ensembl:ENSRNOG00000017226(gene)|ensembl:ENSRNOT00000023256(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)	rgd:628883|refseq:NP_647540.1|ensembl:ENSRNOG00000007584(gene)|ensembl:ENSRNOT00000010701(transcript)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005525"(GTP binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0006897"(endocytosis)|go:"GO:0006907"(pinocytosis)|go:"GO:0016197"(endosomal transport)|go:"GO:0030100"(regulation of endocytosis)|go:"GO:0030139"(endocytic vesicle)|go:"GO:0032456"(endocytic recycling)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0055038"(recycling endosome membrane)|go:"GO:0060271"(cilium assembly)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0072659"(protein localization to plasma membrane)|interpro:IPR000261("EPS15 homology (EH)")|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR011992(EF-Hand type)|interpro:IPR018247|interpro:IPR022812|interpro:IPR027417|interpro:IPR029952|interpro:IPR030381|interpro:IPR031692|interpro:IPR040990	-	-	-	caution:"The participant EBI-349571(P68370) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919386(Q7TP47) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920972(Q5XIP9) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-916419(P11980) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919578(Q8R491) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920554(Q5U3Z7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920647(Q5U2X8) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920585(Q7TP24) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-779677(P05426) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-915744(P02454) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|agonist:Insulin was shown to increase or decrease GLUT4 protein interactions in specific cases.|comment:"Insulin decreased GLUT4 interactions with the following proteins: Q9ER30 (Sarcosin), P09527 (Rab-7), O88960 (N-ethylmaleimide sensitive), P09456 (PKA I regulatory subunit), P27881 (Hexokinase type II), P07872 (Acyl-coenzyme A oxidase), Q6DGF1 (Isocitrate dehydrogenase), Q9EQX9 (Ubiquitin-conjugating), Q63446 (Polyubiquitin), P24268 (Cathepsin D), Q91XW0 (Heat shock protein 86), Q5FVH0 (unknown), P58405 (Striatin 3), Q62667 (Major vault protein), Q66H50 (unknown), Q09167 (splicing factor), Q9JHU5 (Arfaptin 1)."|comment:"Insulin increased GLUT4 interaction with the following proteins:Q9Z1P2 (R-actinin-1), P45592 (Cofilin), Q9QXQ0 (R-actinin-4), P26473 (ADP-ribosylation factor), P26437 (ADP-ribosylation factor),   Q7TNP1 (Basigin 2), Q6P6R2 (Dihydrolipoamide dehydrogenase),   P04797 (GAPDH), Q63081 (Protein disulfide isomerase), P29457 (47 kDa heat shock protein), Q9R1J8 (Leprecan), O88638 (Putative eps protein),   Q64375 (Synaptonemal complex)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:NDPK - Interactions involving proteins containing InterPro domain IPR001564, Nucleoside diphosphate kinase, core.	taxid:10116(rat-l6)|taxid:10116(Rattus norvegicus)	-	2006/02/15	2021/11/30	rogid:PbFY2lfrty8yw40Jq7ShR7xfuV410116	rogid:hlzCptX+8vrzPXfaIshJrxKk+7E10116	intact-crc:44F3A2176D02515F|rigid:9RVm0UBcqQF4k06RGKO89Bg16Q8	false	myc tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P19357	uniprotkb:Q9JJM9	intact:EBI-915426|uniprotkb:P97900|ensembl:ENSRNOP00000023256	intact:EBI-539712|uniprotkb:Q8R2F7|uniprotkb:Q9JJM8	psi-mi:glut4_rat(display_long)|uniprotkb:Glucose transporter type 4, insulin-responsive(gene name synonym)|uniprotkb:Slc2a4(gene name)|psi-mi:Slc2a4(display_short)|uniprotkb:Glut4(gene name synonym)	psi-mi:sept5_rat(display_long)|uniprotkb:Septin5(gene name)|psi-mi:Septin5(display_short)|uniprotkb:Cell division control-related protein 1(gene name synonym)|uniprotkb:Peanut-like protein 1(gene name synonym)|uniprotkb:Pnutl1(gene name synonym)|uniprotkb:Sept5(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Foster et al. (2006)	pubmed:16396496|mint:MINT-5218203	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-921030	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2711|refseq:NP_036883.1|refseq:XP_006246658.1|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007611"(learning or memory)|go:"GO:0007614"(short-term memory)|go:"GO:0007616"(long-term memory)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010021"(amylopectin biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031550"(positive regulation of brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044381"(glucose import in response to insulin stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046323"(glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0098694"(regulation of synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0098793"(presynapse)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002441("Glucose transporter, type 4 (GLUT4)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-189200|ensembl:ENSRNOG00000017226(gene)|ensembl:ENSRNOT00000023256(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)	interpro:IPR027417|interpro:IPR030647|interpro:IPR030379|rgd:621763|interpro:IPR016491(Septin)|mint:Q9JJM9|go:"GO:0005940"(septin ring)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0017157"(regulation of exocytosis)|go:"GO:0005938"(cell cortex)|go:"GO:0019003"(GDP binding)|go:"GO:0019905"(syntaxin binding)|go:"GO:0030534"(adult behavior)|go:"GO:0031105"(septin complex)|go:"GO:0032153"(cell division site)|go:"GO:0032154"(cleavage furrow)|go:"GO:0034613"(cellular protein localization)|go:"GO:0035091"(phosphatidylinositol binding)|go:"GO:0035176"(social behavior)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043195"(terminal bouton)|go:"GO:0043679"(axon terminus)|go:"GO:0044305"(calyx of Held)|go:"GO:0045202"(synapse)|go:"GO:0045921"(positive regulation of exocytosis)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0061640"(cytoskeleton-dependent cytokinesis)|go:"GO:0098793"(presynapse)|go:"GO:0099148"(regulation of synaptic vesicle docking)|go:"GO:0001725"(stress fiber)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005886"(plasma membrane)	-	-	-	caution:"The participant EBI-349571(P68370) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919386(Q7TP47) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920972(Q5XIP9) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-916419(P11980) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919578(Q8R491) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920554(Q5U3Z7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920647(Q5U2X8) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920585(Q7TP24) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-779677(P05426) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-915744(P02454) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|agonist:Insulin was shown to increase or decrease GLUT4 protein interactions in specific cases.|comment:"Insulin decreased GLUT4 interactions with the following proteins: Q9ER30 (Sarcosin), P09527 (Rab-7), O88960 (N-ethylmaleimide sensitive), P09456 (PKA I regulatory subunit), P27881 (Hexokinase type II), P07872 (Acyl-coenzyme A oxidase), Q6DGF1 (Isocitrate dehydrogenase), Q9EQX9 (Ubiquitin-conjugating), Q63446 (Polyubiquitin), P24268 (Cathepsin D), Q91XW0 (Heat shock protein 86), Q5FVH0 (unknown), P58405 (Striatin 3), Q62667 (Major vault protein), Q66H50 (unknown), Q09167 (splicing factor), Q9JHU5 (Arfaptin 1)."|comment:"Insulin increased GLUT4 interaction with the following proteins:Q9Z1P2 (R-actinin-1), P45592 (Cofilin), Q9QXQ0 (R-actinin-4), P26473 (ADP-ribosylation factor), P26437 (ADP-ribosylation factor),   Q7TNP1 (Basigin 2), Q6P6R2 (Dihydrolipoamide dehydrogenase),   P04797 (GAPDH), Q63081 (Protein disulfide isomerase), P29457 (47 kDa heat shock protein), Q9R1J8 (Leprecan), O88638 (Putative eps protein),   Q64375 (Synaptonemal complex)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:NDPK - Interactions involving proteins containing InterPro domain IPR001564, Nucleoside diphosphate kinase, core.	taxid:10116(rat-l6)|taxid:10116(Rattus norvegicus)	-	2006/02/15	2021/11/30	rogid:PbFY2lfrty8yw40Jq7ShR7xfuV410116	rogid:bgzs8rx9e+Yn5zYxczLQYJ11i9g10116	intact-crc:44F3A2176D02515F|rigid:9RVm0UBcqQF4k06RGKO89Bg16Q8	false	myc tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P19357	uniprotkb:Q4QRB4	intact:EBI-915426|uniprotkb:P97900|ensembl:ENSRNOP00000023256	intact:EBI-919537|uniprotkb:Q8K5B6|ensembl:ENSRNOP00000023452	psi-mi:glut4_rat(display_long)|uniprotkb:Glucose transporter type 4, insulin-responsive(gene name synonym)|uniprotkb:Slc2a4(gene name)|psi-mi:Slc2a4(display_short)|uniprotkb:Glut4(gene name synonym)	psi-mi:tbb3_rat(display_long)|uniprotkb:Tubb3(gene name)|psi-mi:Tubb3(display_short)|uniprotkb:Neuron-specific class III beta-tubulin(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Foster et al. (2006)	pubmed:16396496|mint:MINT-5218203	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-921030	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2711|refseq:NP_036883.1|refseq:XP_006246658.1|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007611"(learning or memory)|go:"GO:0007614"(short-term memory)|go:"GO:0007616"(long-term memory)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010021"(amylopectin biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031550"(positive regulation of brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044381"(glucose import in response to insulin stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046323"(glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0098694"(regulation of synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0098793"(presynapse)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002441("Glucose transporter, type 4 (GLUT4)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-189200|ensembl:ENSRNOG00000017226(gene)|ensembl:ENSRNOT00000023256(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)	rgd:628595|refseq:NP_640347.2|ensembl:ENSRNOG00000017209(gene)|ensembl:ENSRNOT00000023452(transcript)|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0005200"(structural constituent of cytoskeleton)|go:"GO:0005525"(GTP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005874"(microtubule)|go:"GO:0007411"(axon guidance)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0030027"(lamellipodium)|go:"GO:0030175"(filopodium)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0038007"(netrin-activated signaling pathway)|go:"GO:0042277"(peptide binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0071944"(cell periphery)|go:"GO:1990791"(dorsal root ganglion development)|go:"GO:1990890"(netrin receptor binding)|interpro:IPR000217(Tubulin)|interpro:IPR002453(Beta tubulin)|interpro:IPR003008(Tubulin/FtsZ, GTPase)|interpro:IPR008280(Tubulin/FtsZ, C-terminal)|interpro:IPR013838(Beta tubulin, autoregulation binding site)|interpro:IPR017975|interpro:IPR018316|interpro:IPR023123|interpro:IPR036525|interpro:IPR037103|mint:Q4QRB4|reactome:R-RNO-190840|reactome:R-RNO-2132295|reactome:R-RNO-2467813|reactome:R-RNO-2500257|reactome:R-RNO-3371497|reactome:R-RNO-380320|reactome:R-RNO-437239|reactome:R-RNO-5610787|reactome:R-RNO-5617833|reactome:R-RNO-5620924|reactome:R-RNO-5626467|reactome:R-RNO-5663220|reactome:R-RNO-6807878|reactome:R-RNO-6811434|reactome:R-RNO-6811436|reactome:R-RNO-68877|reactome:R-RNO-8852276|reactome:R-RNO-8955332|reactome:R-RNO-9646399|reactome:R-RNO-9648025|reactome:R-RNO-9668328|reactome:R-RNO-983189	-	-	-	caution:"The participant EBI-349571(P68370) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919386(Q7TP47) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920972(Q5XIP9) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-916419(P11980) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919578(Q8R491) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920554(Q5U3Z7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920647(Q5U2X8) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920585(Q7TP24) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-779677(P05426) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-915744(P02454) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|agonist:Insulin was shown to increase or decrease GLUT4 protein interactions in specific cases.|comment:"Insulin decreased GLUT4 interactions with the following proteins: Q9ER30 (Sarcosin), P09527 (Rab-7), O88960 (N-ethylmaleimide sensitive), P09456 (PKA I regulatory subunit), P27881 (Hexokinase type II), P07872 (Acyl-coenzyme A oxidase), Q6DGF1 (Isocitrate dehydrogenase), Q9EQX9 (Ubiquitin-conjugating), Q63446 (Polyubiquitin), P24268 (Cathepsin D), Q91XW0 (Heat shock protein 86), Q5FVH0 (unknown), P58405 (Striatin 3), Q62667 (Major vault protein), Q66H50 (unknown), Q09167 (splicing factor), Q9JHU5 (Arfaptin 1)."|comment:"Insulin increased GLUT4 interaction with the following proteins:Q9Z1P2 (R-actinin-1), P45592 (Cofilin), Q9QXQ0 (R-actinin-4), P26473 (ADP-ribosylation factor), P26437 (ADP-ribosylation factor),   Q7TNP1 (Basigin 2), Q6P6R2 (Dihydrolipoamide dehydrogenase),   P04797 (GAPDH), Q63081 (Protein disulfide isomerase), P29457 (47 kDa heat shock protein), Q9R1J8 (Leprecan), O88638 (Putative eps protein),   Q64375 (Synaptonemal complex)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:NDPK - Interactions involving proteins containing InterPro domain IPR001564, Nucleoside diphosphate kinase, core.	taxid:10116(rat-l6)|taxid:10116(Rattus norvegicus)	-	2006/02/15	2021/11/30	rogid:PbFY2lfrty8yw40Jq7ShR7xfuV410116	rogid:KhUQ3YFdcJvjwoHGykl7dv90vX810116	intact-crc:44F3A2176D02515F|rigid:9RVm0UBcqQF4k06RGKO89Bg16Q8	false	myc tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P19357	uniprotkb:Q8K3W5	intact:EBI-915426|uniprotkb:P97900|ensembl:ENSRNOP00000023256	intact:EBI-919530	psi-mi:glut4_rat(display_long)|uniprotkb:Glucose transporter type 4, insulin-responsive(gene name synonym)|uniprotkb:Slc2a4(gene name)|psi-mi:Slc2a4(display_short)|uniprotkb:Glut4(gene name synonym)	psi-mi:q8k3w5_rat(display_long)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Foster et al. (2006)	pubmed:16396496|mint:MINT-5218203	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-921030	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2711|refseq:NP_036883.1|refseq:XP_006246658.1|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007611"(learning or memory)|go:"GO:0007614"(short-term memory)|go:"GO:0007616"(long-term memory)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010021"(amylopectin biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031550"(positive regulation of brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044381"(glucose import in response to insulin stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046323"(glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0098694"(regulation of synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0098793"(presynapse)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002441("Glucose transporter, type 4 (GLUT4)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-189200|ensembl:ENSRNOG00000017226(gene)|ensembl:ENSRNOT00000023256(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)	interpro:IPR029021|interpro:IPR030564|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR010569(Myotubularin-related)	-	-	-	caution:"The participant EBI-349571(P68370) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919386(Q7TP47) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920972(Q5XIP9) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-916419(P11980) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919578(Q8R491) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920554(Q5U3Z7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920647(Q5U2X8) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920585(Q7TP24) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-779677(P05426) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-915744(P02454) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|agonist:Insulin was shown to increase or decrease GLUT4 protein interactions in specific cases.|comment:"Insulin decreased GLUT4 interactions with the following proteins: Q9ER30 (Sarcosin), P09527 (Rab-7), O88960 (N-ethylmaleimide sensitive), P09456 (PKA I regulatory subunit), P27881 (Hexokinase type II), P07872 (Acyl-coenzyme A oxidase), Q6DGF1 (Isocitrate dehydrogenase), Q9EQX9 (Ubiquitin-conjugating), Q63446 (Polyubiquitin), P24268 (Cathepsin D), Q91XW0 (Heat shock protein 86), Q5FVH0 (unknown), P58405 (Striatin 3), Q62667 (Major vault protein), Q66H50 (unknown), Q09167 (splicing factor), Q9JHU5 (Arfaptin 1)."|comment:"Insulin increased GLUT4 interaction with the following proteins:Q9Z1P2 (R-actinin-1), P45592 (Cofilin), Q9QXQ0 (R-actinin-4), P26473 (ADP-ribosylation factor), P26437 (ADP-ribosylation factor),   Q7TNP1 (Basigin 2), Q6P6R2 (Dihydrolipoamide dehydrogenase),   P04797 (GAPDH), Q63081 (Protein disulfide isomerase), P29457 (47 kDa heat shock protein), Q9R1J8 (Leprecan), O88638 (Putative eps protein),   Q64375 (Synaptonemal complex)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:NDPK - Interactions involving proteins containing InterPro domain IPR001564, Nucleoside diphosphate kinase, core.	taxid:10116(rat-l6)|taxid:10116(Rattus norvegicus)	-	2006/02/15	2021/11/30	rogid:PbFY2lfrty8yw40Jq7ShR7xfuV410116	rogid:snmbvzdEzqhqJnoCVtAUM4mbb3Y10116	intact-crc:44F3A2176D02515F|rigid:9RVm0UBcqQF4k06RGKO89Bg16Q8	false	myc tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P19357	uniprotkb:P12368	intact:EBI-915426|uniprotkb:P97900|ensembl:ENSRNOP00000023256	intact:EBI-919521|uniprotkb:Q8K1M2|uniprotkb:G3V8Q6|ensembl:ENSRNOP00000027552	psi-mi:glut4_rat(display_long)|uniprotkb:Glucose transporter type 4, insulin-responsive(gene name synonym)|uniprotkb:Slc2a4(gene name)|psi-mi:Slc2a4(display_short)|uniprotkb:Glut4(gene name synonym)	psi-mi:kap2_rat(display_long)|uniprotkb:Prkar2a(gene name)|psi-mi:Prkar2a(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Foster et al. (2006)	pubmed:16396496|mint:MINT-5218203	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-921030	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2711|refseq:NP_036883.1|refseq:XP_006246658.1|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007611"(learning or memory)|go:"GO:0007614"(short-term memory)|go:"GO:0007616"(long-term memory)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010021"(amylopectin biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031550"(positive regulation of brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044381"(glucose import in response to insulin stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046323"(glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0098694"(regulation of synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0098793"(presynapse)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002441("Glucose transporter, type 4 (GLUT4)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-189200|ensembl:ENSRNOG00000017226(gene)|ensembl:ENSRNOT00000023256(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)	rgd:3393|refseq:NP_062137.1|dip:DIP-555N|ensembl:ENSRNOG00000020284(gene)|ensembl:ENSRNOT00000027552(transcript)|go:"GO:0004862"(cAMP-dependent protein kinase inhibitor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005952"(cAMP-dependent protein kinase complex)|go:"GO:0008603"(cAMP-dependent protein kinase regulator activity)|go:"GO:0010738"(regulation of protein kinase A signaling)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030315"(T-tubule)|go:"GO:0030552"(cAMP binding)|go:"GO:0031588"(nucleotide-activated protein kinase complex)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031698"(beta-2 adrenergic receptor binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034236"(protein kinase A catalytic subunit binding)|go:"GO:0036094"(small molecule binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0043949"(regulation of cAMP-mediated signaling)|go:"GO:0044853"(plasma membrane raft)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045859"(regulation of protein kinase activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0097338"(response to clozapine)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:2000480"(negative regulation of cAMP-dependent protein kinase activity)|interpro:IPR000595(Cyclic nucleotide-binding)|interpro:IPR003117(cAMP-dependent protein kinase, regulatory subunit, type I/II alpha/beta)|interpro:IPR012198(cAMP-dependent protein kinase regulatory subunit)|interpro:IPR014710(RmlC-like jelly roll fold)|interpro:IPR018488|interpro:IPR018490|rcsb pdb:2DRN|rcsb pdb:2H9R|rcsb pdb:2HWN|rcsb pdb:3TMH|reactome:R-RNO-163615|reactome:R-RNO-164378|reactome:R-RNO-180024|reactome:R-RNO-432040|reactome:R-RNO-442720|reactome:R-RNO-5610787|reactome:R-RNO-983231	-	-	-	caution:"The participant EBI-349571(P68370) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919386(Q7TP47) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920972(Q5XIP9) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-916419(P11980) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919578(Q8R491) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920554(Q5U3Z7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920647(Q5U2X8) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920585(Q7TP24) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-779677(P05426) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-915744(P02454) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|agonist:Insulin was shown to increase or decrease GLUT4 protein interactions in specific cases.|comment:"Insulin decreased GLUT4 interactions with the following proteins: Q9ER30 (Sarcosin), P09527 (Rab-7), O88960 (N-ethylmaleimide sensitive), P09456 (PKA I regulatory subunit), P27881 (Hexokinase type II), P07872 (Acyl-coenzyme A oxidase), Q6DGF1 (Isocitrate dehydrogenase), Q9EQX9 (Ubiquitin-conjugating), Q63446 (Polyubiquitin), P24268 (Cathepsin D), Q91XW0 (Heat shock protein 86), Q5FVH0 (unknown), P58405 (Striatin 3), Q62667 (Major vault protein), Q66H50 (unknown), Q09167 (splicing factor), Q9JHU5 (Arfaptin 1)."|comment:"Insulin increased GLUT4 interaction with the following proteins:Q9Z1P2 (R-actinin-1), P45592 (Cofilin), Q9QXQ0 (R-actinin-4), P26473 (ADP-ribosylation factor), P26437 (ADP-ribosylation factor),   Q7TNP1 (Basigin 2), Q6P6R2 (Dihydrolipoamide dehydrogenase),   P04797 (GAPDH), Q63081 (Protein disulfide isomerase), P29457 (47 kDa heat shock protein), Q9R1J8 (Leprecan), O88638 (Putative eps protein),   Q64375 (Synaptonemal complex)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:NDPK - Interactions involving proteins containing InterPro domain IPR001564, Nucleoside diphosphate kinase, core.	taxid:10116(rat-l6)|taxid:10116(Rattus norvegicus)	-	2006/02/15	2021/11/30	rogid:PbFY2lfrty8yw40Jq7ShR7xfuV410116	rogid:ZPxd/oQFtg/sxxKaVa+N/yzkUhY10116	intact-crc:44F3A2176D02515F|rigid:9RVm0UBcqQF4k06RGKO89Bg16Q8	false	myc tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P19357	uniprotkb:Q4QQW8	intact:EBI-915426|uniprotkb:P97900|ensembl:ENSRNOP00000023256	intact:EBI-919516|uniprotkb:A0JN10|uniprotkb:Q3MHS4|uniprotkb:Q5RJZ9|uniprotkb:Q8K1I4|ensembl:ENSRNOP00000001872	psi-mi:glut4_rat(display_long)|uniprotkb:Glucose transporter type 4, insulin-responsive(gene name synonym)|uniprotkb:Slc2a4(gene name)|psi-mi:Slc2a4(display_short)|uniprotkb:Glut4(gene name synonym)	psi-mi:plbl2_rat(display_long)|uniprotkb:Lamina ancestor homolog 2(gene name synonym)|uniprotkb:LAMA-like protein 2(gene name synonym)|uniprotkb:RDCR-0918-3(orf name)|uniprotkb:Plbd2(gene name)|psi-mi:Plbd2(display_short)|uniprotkb:Phospholipase B domain-containing protein 2(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Foster et al. (2006)	pubmed:16396496|mint:MINT-5218203	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-921030	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2711|refseq:NP_036883.1|refseq:XP_006246658.1|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007611"(learning or memory)|go:"GO:0007614"(short-term memory)|go:"GO:0007616"(long-term memory)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010021"(amylopectin biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031550"(positive regulation of brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044381"(glucose import in response to insulin stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046323"(glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0098694"(regulation of synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0098793"(presynapse)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002441("Glucose transporter, type 4 (GLUT4)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-189200|ensembl:ENSRNOG00000017226(gene)|ensembl:ENSRNOT00000023256(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)	rgd:708461|refseq:NP_640348.2|ensembl:ENSRNOG00000001385(gene)|ensembl:ENSRNOT00000001872(transcript)|go:"GO:0004620"(phospholipase activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005764"(lysosome)|go:"GO:0009395"(phospholipid catabolic process)|go:"GO:0043202"(lysosomal lumen)|interpro:IPR007000(Laminin A)|interpro:IPR043040|interpro:IPR043041|interpro:IPR043042	-	-	-	caution:"The participant EBI-349571(P68370) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919386(Q7TP47) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920972(Q5XIP9) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-916419(P11980) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919578(Q8R491) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920554(Q5U3Z7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920647(Q5U2X8) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920585(Q7TP24) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-779677(P05426) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-915744(P02454) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|agonist:Insulin was shown to increase or decrease GLUT4 protein interactions in specific cases.|comment:"Insulin decreased GLUT4 interactions with the following proteins: Q9ER30 (Sarcosin), P09527 (Rab-7), O88960 (N-ethylmaleimide sensitive), P09456 (PKA I regulatory subunit), P27881 (Hexokinase type II), P07872 (Acyl-coenzyme A oxidase), Q6DGF1 (Isocitrate dehydrogenase), Q9EQX9 (Ubiquitin-conjugating), Q63446 (Polyubiquitin), P24268 (Cathepsin D), Q91XW0 (Heat shock protein 86), Q5FVH0 (unknown), P58405 (Striatin 3), Q62667 (Major vault protein), Q66H50 (unknown), Q09167 (splicing factor), Q9JHU5 (Arfaptin 1)."|comment:"Insulin increased GLUT4 interaction with the following proteins:Q9Z1P2 (R-actinin-1), P45592 (Cofilin), Q9QXQ0 (R-actinin-4), P26473 (ADP-ribosylation factor), P26437 (ADP-ribosylation factor),   Q7TNP1 (Basigin 2), Q6P6R2 (Dihydrolipoamide dehydrogenase),   P04797 (GAPDH), Q63081 (Protein disulfide isomerase), P29457 (47 kDa heat shock protein), Q9R1J8 (Leprecan), O88638 (Putative eps protein),   Q64375 (Synaptonemal complex)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:NDPK - Interactions involving proteins containing InterPro domain IPR001564, Nucleoside diphosphate kinase, core.	taxid:10116(rat-l6)|taxid:10116(Rattus norvegicus)	-	2006/02/15	2021/11/30	rogid:PbFY2lfrty8yw40Jq7ShR7xfuV410116	rogid:jyskGtYfamJgIQNRsi7xxSnkZG010116	intact-crc:44F3A2176D02515F|rigid:9RVm0UBcqQF4k06RGKO89Bg16Q8	false	myc tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P19357	uniprotkb:P21263	intact:EBI-915426|uniprotkb:P97900|ensembl:ENSRNOP00000023256	intact:EBI-919509|uniprotkb:Q8CJ14	psi-mi:glut4_rat(display_long)|uniprotkb:Glucose transporter type 4, insulin-responsive(gene name synonym)|uniprotkb:Slc2a4(gene name)|psi-mi:Slc2a4(display_short)|uniprotkb:Glut4(gene name synonym)	psi-mi:nest_rat(display_long)|uniprotkb:Nes(gene name)|psi-mi:Nes(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Foster et al. (2006)	pubmed:16396496|mint:MINT-5218203	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-921030	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2711|refseq:NP_036883.1|refseq:XP_006246658.1|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007611"(learning or memory)|go:"GO:0007614"(short-term memory)|go:"GO:0007616"(long-term memory)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010021"(amylopectin biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031550"(positive regulation of brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044381"(glucose import in response to insulin stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046323"(glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0098694"(regulation of synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0098793"(presynapse)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002441("Glucose transporter, type 4 (GLUT4)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-189200|ensembl:ENSRNOG00000017226(gene)|ensembl:ENSRNOT00000023256(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)	rgd:3162|interpro:IPR018039|interpro:IPR031211|interpro:IPR039008|mint:P21263|go:"GO:0000086"(G2/M transition of mitotic cell cycle)|go:"GO:0005737"(cytoplasm)|go:"GO:0005882"(intermediate filament)|go:"GO:0007399"(nervous system development)|go:"GO:0007420"(brain development)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0019215"(intermediate filament binding)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030844"(positive regulation of intermediate filament depolymerization)|go:"GO:0031076"(embryonic camera-type eye development)|go:"GO:0031667"(response to nutrient levels)|go:"GO:0031730"(CCR5 chemokine receptor binding)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0042493"|go:"GO:0043086"(negative regulation of catalytic activity)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0048858"(cell projection morphogenesis)|go:"GO:0072089"(stem cell proliferation)|go:"GO:2000179"(positive regulation of neural precursor cell proliferation)	-	-	-	caution:"The participant EBI-349571(P68370) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919386(Q7TP47) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920972(Q5XIP9) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-916419(P11980) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919578(Q8R491) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920554(Q5U3Z7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920647(Q5U2X8) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920585(Q7TP24) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-779677(P05426) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-915744(P02454) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|agonist:Insulin was shown to increase or decrease GLUT4 protein interactions in specific cases.|comment:"Insulin decreased GLUT4 interactions with the following proteins: Q9ER30 (Sarcosin), P09527 (Rab-7), O88960 (N-ethylmaleimide sensitive), P09456 (PKA I regulatory subunit), P27881 (Hexokinase type II), P07872 (Acyl-coenzyme A oxidase), Q6DGF1 (Isocitrate dehydrogenase), Q9EQX9 (Ubiquitin-conjugating), Q63446 (Polyubiquitin), P24268 (Cathepsin D), Q91XW0 (Heat shock protein 86), Q5FVH0 (unknown), P58405 (Striatin 3), Q62667 (Major vault protein), Q66H50 (unknown), Q09167 (splicing factor), Q9JHU5 (Arfaptin 1)."|comment:"Insulin increased GLUT4 interaction with the following proteins:Q9Z1P2 (R-actinin-1), P45592 (Cofilin), Q9QXQ0 (R-actinin-4), P26473 (ADP-ribosylation factor), P26437 (ADP-ribosylation factor),   Q7TNP1 (Basigin 2), Q6P6R2 (Dihydrolipoamide dehydrogenase),   P04797 (GAPDH), Q63081 (Protein disulfide isomerase), P29457 (47 kDa heat shock protein), Q9R1J8 (Leprecan), O88638 (Putative eps protein),   Q64375 (Synaptonemal complex)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:NDPK - Interactions involving proteins containing InterPro domain IPR001564, Nucleoside diphosphate kinase, core.	taxid:10116(rat-l6)|taxid:10116(Rattus norvegicus)	-	2006/02/15	2021/11/30	rogid:PbFY2lfrty8yw40Jq7ShR7xfuV410116	rogid:/ZDbmeWj7+7ft2+l9Y4BqX0P0C810116	intact-crc:44F3A2176D02515F|rigid:9RVm0UBcqQF4k06RGKO89Bg16Q8	false	myc tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P19357	uniprotkb:Q8CGU6	intact:EBI-915426|uniprotkb:P97900|ensembl:ENSRNOP00000023256	intact:EBI-919483|uniprotkb:Q8CH12|ensembl:ENSRNOP00000008150	psi-mi:glut4_rat(display_long)|uniprotkb:Glucose transporter type 4, insulin-responsive(gene name synonym)|uniprotkb:Slc2a4(gene name)|psi-mi:Slc2a4(display_short)|uniprotkb:Glut4(gene name synonym)	psi-mi:nica_rat(display_long)|uniprotkb:Ncstn(gene name)|psi-mi:Ncstn(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Foster et al. (2006)	pubmed:16396496|mint:MINT-5218203	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-921030	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2711|refseq:NP_036883.1|refseq:XP_006246658.1|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007611"(learning or memory)|go:"GO:0007614"(short-term memory)|go:"GO:0007616"(long-term memory)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010021"(amylopectin biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031550"(positive regulation of brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044381"(glucose import in response to insulin stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046323"(glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0098694"(regulation of synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0098793"(presynapse)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002441("Glucose transporter, type 4 (GLUT4)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-189200|ensembl:ENSRNOG00000017226(gene)|ensembl:ENSRNOT00000023256(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)	rgd:631418|refseq:NP_777353.1|refseq:XP_008767955.1|ensembl:ENSRNOG00000005355(gene)|ensembl:ENSRNOT00000008150(transcript)|go:"GO:0002262"(myeloid cell homeostasis)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006509"(membrane protein ectodomain proteolysis)|go:"GO:0007212"(dopamine receptor signaling pathway)|go:"GO:0007215"(glutamate receptor signaling pathway)|go:"GO:0007219"(Notch signaling pathway)|go:"GO:0007220"(Notch receptor processing)|go:"GO:0007611"(learning or memory)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008233"(peptidase activity)|go:"GO:0010950"(positive regulation of endopeptidase activity)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016485"(protein processing)|go:"GO:0021549"(cerebellum development)|go:"GO:0022010"(central nervous system myelination)|go:"GO:0030534"(adult behavior)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034205"(amyloid-beta formation)|go:"GO:0042098"(T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0042470"(melanosome)|go:"GO:0042500"(aspartic endopeptidase activity, intramembrane cleaving)|go:"GO:0042982"(amyloid precursor protein metabolic process)|go:"GO:0042983"(amyloid precursor protein biosynthetic process)|go:"GO:0042986"(positive regulation of amyloid precursor protein biosynthetic process)|go:"GO:0042987"(amyloid precursor protein catabolic process)|go:"GO:0043085"(positive regulation of catalytic activity)|go:"GO:0045202"(synapse)|go:"GO:0050435"(amyloid-beta metabolic process)|go:"GO:0050673"(epithelial cell proliferation)|go:"GO:0051117"(ATPase binding)|go:"GO:0051402"(neuron apoptotic process)|go:"GO:0070765"(gamma-secretase complex)|go:"GO:0070851"(growth factor receptor binding)|go:"GO:0070997"(neuron death)|go:"GO:0071277"(cellular response to calcium ion)|go:"GO:0097060"(synaptic membrane)|go:"GO:0099056"(integral component of presynaptic membrane)|go:"GO:1900271"(regulation of long-term synaptic potentiation)|go:"GO:1990926"(short-term synaptic potentiation)|interpro:IPR008710(Nicastrin)|interpro:IPR041084|reactome:R-RNO-1251985|reactome:R-RNO-193692|reactome:R-RNO-205043|reactome:R-RNO-3928665|reactome:R-RNO-6798695|reactome:R-RNO-9013507|reactome:R-RNO-9017802	-	-	-	caution:"The participant EBI-349571(P68370) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919386(Q7TP47) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920972(Q5XIP9) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-916419(P11980) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919578(Q8R491) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920554(Q5U3Z7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920647(Q5U2X8) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920585(Q7TP24) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-779677(P05426) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-915744(P02454) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|agonist:Insulin was shown to increase or decrease GLUT4 protein interactions in specific cases.|comment:"Insulin decreased GLUT4 interactions with the following proteins: Q9ER30 (Sarcosin), P09527 (Rab-7), O88960 (N-ethylmaleimide sensitive), P09456 (PKA I regulatory subunit), P27881 (Hexokinase type II), P07872 (Acyl-coenzyme A oxidase), Q6DGF1 (Isocitrate dehydrogenase), Q9EQX9 (Ubiquitin-conjugating), Q63446 (Polyubiquitin), P24268 (Cathepsin D), Q91XW0 (Heat shock protein 86), Q5FVH0 (unknown), P58405 (Striatin 3), Q62667 (Major vault protein), Q66H50 (unknown), Q09167 (splicing factor), Q9JHU5 (Arfaptin 1)."|comment:"Insulin increased GLUT4 interaction with the following proteins:Q9Z1P2 (R-actinin-1), P45592 (Cofilin), Q9QXQ0 (R-actinin-4), P26473 (ADP-ribosylation factor), P26437 (ADP-ribosylation factor),   Q7TNP1 (Basigin 2), Q6P6R2 (Dihydrolipoamide dehydrogenase),   P04797 (GAPDH), Q63081 (Protein disulfide isomerase), P29457 (47 kDa heat shock protein), Q9R1J8 (Leprecan), O88638 (Putative eps protein),   Q64375 (Synaptonemal complex)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:NDPK - Interactions involving proteins containing InterPro domain IPR001564, Nucleoside diphosphate kinase, core.	taxid:10116(rat-l6)|taxid:10116(Rattus norvegicus)	-	2006/02/15	2021/11/30	rogid:PbFY2lfrty8yw40Jq7ShR7xfuV410116	rogid:i7mLB/dG+pTidsJNUywhbvAzjDs10116	intact-crc:44F3A2176D02515F|rigid:9RVm0UBcqQF4k06RGKO89Bg16Q8	false	myc tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P19357	uniprotkb:Q8VI04	intact:EBI-915426|uniprotkb:P97900|ensembl:ENSRNOP00000023256	intact:EBI-919475|uniprotkb:Q8CG44|ensembl:ENSRNOP00000027459	psi-mi:glut4_rat(display_long)|uniprotkb:Glucose transporter type 4, insulin-responsive(gene name synonym)|uniprotkb:Slc2a4(gene name)|psi-mi:Slc2a4(display_short)|uniprotkb:Glut4(gene name synonym)	psi-mi:asgl1_rat(display_long)|uniprotkb:Alp(gene name synonym)|uniprotkb:Asrgl1(gene name)|psi-mi:Asrgl1(display_short)|uniprotkb:Gliap(gene name synonym)|uniprotkb:Hiob(gene name synonym)|uniprotkb:L-asparagine amidohydrolase(gene name synonym)|uniprotkb:Asparaginase-like protein 1(gene name synonym)|uniprotkb:Asparaginase-like sperm autoantigen(gene name synonym)|uniprotkb:Glial asparaginase(gene name synonym)|uniprotkb:Beta-aspartyl-peptidase(gene name synonym)|uniprotkb:Isoaspartyl dipeptidase(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Foster et al. (2006)	pubmed:16396496|mint:MINT-5218203	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-921030	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2711|refseq:NP_036883.1|refseq:XP_006246658.1|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007611"(learning or memory)|go:"GO:0007614"(short-term memory)|go:"GO:0007616"(long-term memory)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010021"(amylopectin biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031550"(positive regulation of brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044381"(glucose import in response to insulin stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046323"(glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0098694"(regulation of synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0098793"(presynapse)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002441("Glucose transporter, type 4 (GLUT4)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-189200|ensembl:ENSRNOG00000017226(gene)|ensembl:ENSRNOT00000023256(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)	rgd:708526|refseq:NP_659557.1|ensembl:ENSRNOG00000020202(gene)|ensembl:ENSRNOT00000027459(transcript)|go:"GO:0001917"(photoreceptor inner segment)|go:"GO:0004067"(asparaginase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0008798"(beta-aspartyl-peptidase activity)|go:"GO:0033345"(asparagine catabolic process via L-aspartate)|interpro:IPR000246(Peptidase T2, asparaginase 2)|interpro:IPR029055|interpro:IPR033844|reactome:R-RNO-8964208	-	-	-	caution:"The participant EBI-349571(P68370) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919386(Q7TP47) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920972(Q5XIP9) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-916419(P11980) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919578(Q8R491) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920554(Q5U3Z7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920647(Q5U2X8) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920585(Q7TP24) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-779677(P05426) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-915744(P02454) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|agonist:Insulin was shown to increase or decrease GLUT4 protein interactions in specific cases.|comment:"Insulin decreased GLUT4 interactions with the following proteins: Q9ER30 (Sarcosin), P09527 (Rab-7), O88960 (N-ethylmaleimide sensitive), P09456 (PKA I regulatory subunit), P27881 (Hexokinase type II), P07872 (Acyl-coenzyme A oxidase), Q6DGF1 (Isocitrate dehydrogenase), Q9EQX9 (Ubiquitin-conjugating), Q63446 (Polyubiquitin), P24268 (Cathepsin D), Q91XW0 (Heat shock protein 86), Q5FVH0 (unknown), P58405 (Striatin 3), Q62667 (Major vault protein), Q66H50 (unknown), Q09167 (splicing factor), Q9JHU5 (Arfaptin 1)."|comment:"Insulin increased GLUT4 interaction with the following proteins:Q9Z1P2 (R-actinin-1), P45592 (Cofilin), Q9QXQ0 (R-actinin-4), P26473 (ADP-ribosylation factor), P26437 (ADP-ribosylation factor),   Q7TNP1 (Basigin 2), Q6P6R2 (Dihydrolipoamide dehydrogenase),   P04797 (GAPDH), Q63081 (Protein disulfide isomerase), P29457 (47 kDa heat shock protein), Q9R1J8 (Leprecan), O88638 (Putative eps protein),   Q64375 (Synaptonemal complex)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:NDPK - Interactions involving proteins containing InterPro domain IPR001564, Nucleoside diphosphate kinase, core.	taxid:10116(rat-l6)|taxid:10116(Rattus norvegicus)	-	2006/02/15	2021/11/30	rogid:PbFY2lfrty8yw40Jq7ShR7xfuV410116	rogid:hOxtn1igtYyMQPto73w6lqpy9ew10116	intact-crc:44F3A2176D02515F|rigid:9RVm0UBcqQF4k06RGKO89Bg16Q8	false	myc tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P19357	uniprotkb:Q812C4	intact:EBI-915426|uniprotkb:P97900|ensembl:ENSRNOP00000023256	intact:EBI-919462	psi-mi:glut4_rat(display_long)|uniprotkb:Glucose transporter type 4, insulin-responsive(gene name synonym)|uniprotkb:Slc2a4(gene name)|psi-mi:Slc2a4(display_short)|uniprotkb:Glut4(gene name synonym)	psi-mi:q812c4_rat(display_long)|uniprotkb:Eif4a1(gene name)|psi-mi:Eif4a1(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Foster et al. (2006)	pubmed:16396496|mint:MINT-5218203	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-921030	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2711|refseq:NP_036883.1|refseq:XP_006246658.1|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007611"(learning or memory)|go:"GO:0007614"(short-term memory)|go:"GO:0007616"(long-term memory)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010021"(amylopectin biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031550"(positive regulation of brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044381"(glucose import in response to insulin stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046323"(glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0098694"(regulation of synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0098793"(presynapse)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002441("Glucose transporter, type 4 (GLUT4)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-189200|ensembl:ENSRNOG00000017226(gene)|ensembl:ENSRNOT00000023256(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)	interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR011545(DNA/RNA helicase, DEAD/DEAH box type, N-terminal)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR000629(RNA helicase, ATP-dependent, DEAD-box, conserved site)|interpro:IPR027417|go:"GO:0003743"(translation initiation factor activity)|go:"GO:0004386"(helicase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0016787"(hydrolase activity)	-	-	-	caution:"The participant EBI-349571(P68370) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919386(Q7TP47) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920972(Q5XIP9) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-916419(P11980) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919578(Q8R491) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920554(Q5U3Z7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920647(Q5U2X8) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920585(Q7TP24) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-779677(P05426) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-915744(P02454) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|agonist:Insulin was shown to increase or decrease GLUT4 protein interactions in specific cases.|comment:"Insulin decreased GLUT4 interactions with the following proteins: Q9ER30 (Sarcosin), P09527 (Rab-7), O88960 (N-ethylmaleimide sensitive), P09456 (PKA I regulatory subunit), P27881 (Hexokinase type II), P07872 (Acyl-coenzyme A oxidase), Q6DGF1 (Isocitrate dehydrogenase), Q9EQX9 (Ubiquitin-conjugating), Q63446 (Polyubiquitin), P24268 (Cathepsin D), Q91XW0 (Heat shock protein 86), Q5FVH0 (unknown), P58405 (Striatin 3), Q62667 (Major vault protein), Q66H50 (unknown), Q09167 (splicing factor), Q9JHU5 (Arfaptin 1)."|comment:"Insulin increased GLUT4 interaction with the following proteins:Q9Z1P2 (R-actinin-1), P45592 (Cofilin), Q9QXQ0 (R-actinin-4), P26473 (ADP-ribosylation factor), P26437 (ADP-ribosylation factor),   Q7TNP1 (Basigin 2), Q6P6R2 (Dihydrolipoamide dehydrogenase),   P04797 (GAPDH), Q63081 (Protein disulfide isomerase), P29457 (47 kDa heat shock protein), Q9R1J8 (Leprecan), O88638 (Putative eps protein),   Q64375 (Synaptonemal complex)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:NDPK - Interactions involving proteins containing InterPro domain IPR001564, Nucleoside diphosphate kinase, core.	taxid:10116(rat-l6)|taxid:10116(Rattus norvegicus)	-	2006/02/15	2021/11/30	rogid:PbFY2lfrty8yw40Jq7ShR7xfuV410116	rogid:1JyZvwhTU2P2Wr03LvoJ71TMVFg10116	intact-crc:44F3A2176D02515F|rigid:9RVm0UBcqQF4k06RGKO89Bg16Q8	false	myc tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P19357	uniprotkb:Q5U367	intact:EBI-915426|uniprotkb:P97900|ensembl:ENSRNOP00000023256	intact:EBI-919454|uniprotkb:Q811A5|ensembl:ENSRNOP00000001921	psi-mi:glut4_rat(display_long)|uniprotkb:Glucose transporter type 4, insulin-responsive(gene name synonym)|uniprotkb:Slc2a4(gene name)|psi-mi:Slc2a4(display_short)|uniprotkb:Glut4(gene name synonym)	psi-mi:plod3_rat(display_long)|uniprotkb:Plod3(gene name)|psi-mi:Plod3(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Foster et al. (2006)	pubmed:16396496|mint:MINT-5218203	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-921030	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2711|refseq:NP_036883.1|refseq:XP_006246658.1|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007611"(learning or memory)|go:"GO:0007614"(short-term memory)|go:"GO:0007616"(long-term memory)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010021"(amylopectin biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031550"(positive regulation of brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044381"(glucose import in response to insulin stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046323"(glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0098694"(regulation of synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0098793"(presynapse)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002441("Glucose transporter, type 4 (GLUT4)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-189200|ensembl:ENSRNOG00000017226(gene)|ensembl:ENSRNOT00000023256(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)	rgd:631339|refseq:NP_835202.2|ensembl:ENSRNOG00000001417(gene)|ensembl:ENSRNOT00000001921(transcript)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001886"(endothelial cell morphogenesis)|go:"GO:0005506"(iron ion binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0006493"(protein O-linked glycosylation)|go:"GO:0008104"(protein localization)|go:"GO:0008475"(procollagen-lysine 5-dioxygenase activity)|go:"GO:0017185"(peptidyl-lysine hydroxylation)|go:"GO:0021915"(neural tube development)|go:"GO:0030199"(collagen fibril organization)|go:"GO:0031418"(L-ascorbic acid binding)|go:"GO:0032870"(cellular response to hormone stimulus)|go:"GO:0032963"(collagen metabolic process)|go:"GO:0033823"(procollagen glucosyltransferase activity)|go:"GO:0042311"(vasodilation)|go:"GO:0046947"(hydroxylysine biosynthetic process)|go:"GO:0048730"(epidermis morphogenesis)|go:"GO:0050211"(procollagen galactosyltransferase activity)|go:"GO:0060425"(lung morphogenesis)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070831"(basement membrane assembly)|interpro:IPR001006(Procollagen-lysine 5-dioxygenase)|interpro:IPR005123("2OG-Fe(II) oxygenase")|interpro:IPR006620(Prolyl 4-hydroxylase, alpha subunit)|interpro:IPR029044|reactome:R-RNO-1650814	-	-	-	caution:"The participant EBI-349571(P68370) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919386(Q7TP47) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920972(Q5XIP9) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-916419(P11980) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919578(Q8R491) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920554(Q5U3Z7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920647(Q5U2X8) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920585(Q7TP24) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-779677(P05426) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-915744(P02454) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|agonist:Insulin was shown to increase or decrease GLUT4 protein interactions in specific cases.|comment:"Insulin decreased GLUT4 interactions with the following proteins: Q9ER30 (Sarcosin), P09527 (Rab-7), O88960 (N-ethylmaleimide sensitive), P09456 (PKA I regulatory subunit), P27881 (Hexokinase type II), P07872 (Acyl-coenzyme A oxidase), Q6DGF1 (Isocitrate dehydrogenase), Q9EQX9 (Ubiquitin-conjugating), Q63446 (Polyubiquitin), P24268 (Cathepsin D), Q91XW0 (Heat shock protein 86), Q5FVH0 (unknown), P58405 (Striatin 3), Q62667 (Major vault protein), Q66H50 (unknown), Q09167 (splicing factor), Q9JHU5 (Arfaptin 1)."|comment:"Insulin increased GLUT4 interaction with the following proteins:Q9Z1P2 (R-actinin-1), P45592 (Cofilin), Q9QXQ0 (R-actinin-4), P26473 (ADP-ribosylation factor), P26437 (ADP-ribosylation factor),   Q7TNP1 (Basigin 2), Q6P6R2 (Dihydrolipoamide dehydrogenase),   P04797 (GAPDH), Q63081 (Protein disulfide isomerase), P29457 (47 kDa heat shock protein), Q9R1J8 (Leprecan), O88638 (Putative eps protein),   Q64375 (Synaptonemal complex)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:NDPK - Interactions involving proteins containing InterPro domain IPR001564, Nucleoside diphosphate kinase, core.	taxid:10116(rat-l6)|taxid:10116(Rattus norvegicus)	-	2006/02/15	2021/11/30	rogid:PbFY2lfrty8yw40Jq7ShR7xfuV410116	rogid:qoLg25BcgEkKy3aQes87wopHfAI10116	intact-crc:44F3A2176D02515F|rigid:9RVm0UBcqQF4k06RGKO89Bg16Q8	false	myc tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P19357	uniprotkb:Q7TSP3	intact:EBI-915426|uniprotkb:P97900|ensembl:ENSRNOP00000023256	intact:EBI-919449	psi-mi:glut4_rat(display_long)|uniprotkb:Glucose transporter type 4, insulin-responsive(gene name synonym)|uniprotkb:Slc2a4(gene name)|psi-mi:Slc2a4(display_short)|uniprotkb:Glut4(gene name synonym)	psi-mi:q7tsp3_rat(display_long)|uniprotkb:NYGGF2(gene name)|psi-mi:NYGGF2(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Foster et al. (2006)	pubmed:16396496|mint:MINT-5218203	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-921030	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2711|refseq:NP_036883.1|refseq:XP_006246658.1|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007611"(learning or memory)|go:"GO:0007614"(short-term memory)|go:"GO:0007616"(long-term memory)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010021"(amylopectin biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031550"(positive regulation of brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044381"(glucose import in response to insulin stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046323"(glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0098694"(regulation of synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0098793"(presynapse)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002441("Glucose transporter, type 4 (GLUT4)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-189200|ensembl:ENSRNOG00000017226(gene)|ensembl:ENSRNOT00000023256(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)	interpro:IPR036250|go:"GO:0016627"(oxidoreductase activity, acting on the CH-CH group of donors)	-	-	-	caution:"The participant EBI-349571(P68370) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919386(Q7TP47) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920972(Q5XIP9) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-916419(P11980) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919578(Q8R491) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920554(Q5U3Z7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920647(Q5U2X8) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920585(Q7TP24) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-779677(P05426) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-915744(P02454) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|agonist:Insulin was shown to increase or decrease GLUT4 protein interactions in specific cases.|comment:"Insulin decreased GLUT4 interactions with the following proteins: Q9ER30 (Sarcosin), P09527 (Rab-7), O88960 (N-ethylmaleimide sensitive), P09456 (PKA I regulatory subunit), P27881 (Hexokinase type II), P07872 (Acyl-coenzyme A oxidase), Q6DGF1 (Isocitrate dehydrogenase), Q9EQX9 (Ubiquitin-conjugating), Q63446 (Polyubiquitin), P24268 (Cathepsin D), Q91XW0 (Heat shock protein 86), Q5FVH0 (unknown), P58405 (Striatin 3), Q62667 (Major vault protein), Q66H50 (unknown), Q09167 (splicing factor), Q9JHU5 (Arfaptin 1)."|comment:"Insulin increased GLUT4 interaction with the following proteins:Q9Z1P2 (R-actinin-1), P45592 (Cofilin), Q9QXQ0 (R-actinin-4), P26473 (ADP-ribosylation factor), P26437 (ADP-ribosylation factor),   Q7TNP1 (Basigin 2), Q6P6R2 (Dihydrolipoamide dehydrogenase),   P04797 (GAPDH), Q63081 (Protein disulfide isomerase), P29457 (47 kDa heat shock protein), Q9R1J8 (Leprecan), O88638 (Putative eps protein),   Q64375 (Synaptonemal complex)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:NDPK - Interactions involving proteins containing InterPro domain IPR001564, Nucleoside diphosphate kinase, core.	taxid:10116(rat-l6)|taxid:10116(Rattus norvegicus)	-	2006/02/15	2021/11/30	rogid:PbFY2lfrty8yw40Jq7ShR7xfuV410116	rogid:CbKKsgiEAIo3owIcSG88lvE2Lsg10116	intact-crc:44F3A2176D02515F|rigid:9RVm0UBcqQF4k06RGKO89Bg16Q8	false	myc tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P19357	uniprotkb:Q7TPK5	intact:EBI-915426|uniprotkb:P97900|ensembl:ENSRNOP00000023256	intact:EBI-919441|ensembl:ENSRNOP00000051487	psi-mi:glut4_rat(display_long)|uniprotkb:Glucose transporter type 4, insulin-responsive(gene name synonym)|uniprotkb:Slc2a4(gene name)|psi-mi:Slc2a4(display_short)|uniprotkb:Glut4(gene name synonym)	psi-mi:q7tpk5_rat(display_long)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Foster et al. (2006)	pubmed:16396496|mint:MINT-5218203	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-921030	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2711|refseq:NP_036883.1|refseq:XP_006246658.1|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007611"(learning or memory)|go:"GO:0007614"(short-term memory)|go:"GO:0007616"(long-term memory)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010021"(amylopectin biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031550"(positive regulation of brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044381"(glucose import in response to insulin stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046323"(glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0098694"(regulation of synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0098793"(presynapse)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002441("Glucose transporter, type 4 (GLUT4)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-189200|ensembl:ENSRNOG00000017226(gene)|ensembl:ENSRNOT00000023256(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)	ensembl:ENSRNOG00000031628(gene)|ensembl:ENSRNOT00000047024(transcript)|go:"GO:0003746"(translation elongation factor activity)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005829"(cytosol)|go:"GO:0005853"(eukaryotic translation elongation factor 1 complex)|go:"GO:0006414"(translational elongation)|go:"GO:0016021"(integral component of membrane)|interpro:IPR001326(Translation elongation factor EF1B, beta/delta chains, conserved site)|interpro:IPR014038(Translation elongation factor EF1B, beta and delta chains, guanine nucleotide exchange)|interpro:IPR014717(Translation elongation  factor EF1B/ribosomal protein S6)|interpro:IPR018940|interpro:IPR036219	-	-	-	caution:"The participant EBI-349571(P68370) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919386(Q7TP47) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920972(Q5XIP9) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-916419(P11980) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919578(Q8R491) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920554(Q5U3Z7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920647(Q5U2X8) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920585(Q7TP24) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-779677(P05426) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-915744(P02454) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|agonist:Insulin was shown to increase or decrease GLUT4 protein interactions in specific cases.|comment:"Insulin decreased GLUT4 interactions with the following proteins: Q9ER30 (Sarcosin), P09527 (Rab-7), O88960 (N-ethylmaleimide sensitive), P09456 (PKA I regulatory subunit), P27881 (Hexokinase type II), P07872 (Acyl-coenzyme A oxidase), Q6DGF1 (Isocitrate dehydrogenase), Q9EQX9 (Ubiquitin-conjugating), Q63446 (Polyubiquitin), P24268 (Cathepsin D), Q91XW0 (Heat shock protein 86), Q5FVH0 (unknown), P58405 (Striatin 3), Q62667 (Major vault protein), Q66H50 (unknown), Q09167 (splicing factor), Q9JHU5 (Arfaptin 1)."|comment:"Insulin increased GLUT4 interaction with the following proteins:Q9Z1P2 (R-actinin-1), P45592 (Cofilin), Q9QXQ0 (R-actinin-4), P26473 (ADP-ribosylation factor), P26437 (ADP-ribosylation factor),   Q7TNP1 (Basigin 2), Q6P6R2 (Dihydrolipoamide dehydrogenase),   P04797 (GAPDH), Q63081 (Protein disulfide isomerase), P29457 (47 kDa heat shock protein), Q9R1J8 (Leprecan), O88638 (Putative eps protein),   Q64375 (Synaptonemal complex)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:NDPK - Interactions involving proteins containing InterPro domain IPR001564, Nucleoside diphosphate kinase, core.	taxid:10116(rat-l6)|taxid:10116(Rattus norvegicus)	-	2006/02/15	2021/11/30	rogid:PbFY2lfrty8yw40Jq7ShR7xfuV410116	rogid:wifyYGVqPeRk4zPHYGs7ETWbUEU10116	intact-crc:44F3A2176D02515F|rigid:9RVm0UBcqQF4k06RGKO89Bg16Q8	false	myc tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P19357	uniprotkb:Q7TPJ0	intact:EBI-915426|uniprotkb:P97900|ensembl:ENSRNOP00000023256	intact:EBI-919435	psi-mi:glut4_rat(display_long)|uniprotkb:Glucose transporter type 4, insulin-responsive(gene name synonym)|uniprotkb:Slc2a4(gene name)|psi-mi:Slc2a4(display_short)|uniprotkb:Glut4(gene name synonym)	psi-mi:ssra_rat(display_long)|uniprotkb:Ssr1(gene name)|psi-mi:Ssr1(display_short)|uniprotkb:Ac2-238(orf name)|uniprotkb:Signal sequence receptor subunit alpha(gene name synonym)|uniprotkb:Liver regeneration-related protein LRRG137(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Foster et al. (2006)	pubmed:16396496|mint:MINT-5218203	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-921030	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2711|refseq:NP_036883.1|refseq:XP_006246658.1|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007611"(learning or memory)|go:"GO:0007614"(short-term memory)|go:"GO:0007616"(long-term memory)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010021"(amylopectin biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031550"(positive regulation of brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044381"(glucose import in response to insulin stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046323"(glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0098694"(regulation of synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0098793"(presynapse)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002441("Glucose transporter, type 4 (GLUT4)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-189200|ensembl:ENSRNOG00000017226(gene)|ensembl:ENSRNOT00000023256(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)	interpro:IPR005595("Translocon-associated protein (TRAP), alpha subunit")|rgd:1310961|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0016021"(integral component of membrane)	-	-	-	caution:"The participant EBI-349571(P68370) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919386(Q7TP47) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920972(Q5XIP9) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-916419(P11980) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919578(Q8R491) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920554(Q5U3Z7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920647(Q5U2X8) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920585(Q7TP24) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-779677(P05426) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-915744(P02454) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|agonist:Insulin was shown to increase or decrease GLUT4 protein interactions in specific cases.|comment:"Insulin decreased GLUT4 interactions with the following proteins: Q9ER30 (Sarcosin), P09527 (Rab-7), O88960 (N-ethylmaleimide sensitive), P09456 (PKA I regulatory subunit), P27881 (Hexokinase type II), P07872 (Acyl-coenzyme A oxidase), Q6DGF1 (Isocitrate dehydrogenase), Q9EQX9 (Ubiquitin-conjugating), Q63446 (Polyubiquitin), P24268 (Cathepsin D), Q91XW0 (Heat shock protein 86), Q5FVH0 (unknown), P58405 (Striatin 3), Q62667 (Major vault protein), Q66H50 (unknown), Q09167 (splicing factor), Q9JHU5 (Arfaptin 1)."|comment:"Insulin increased GLUT4 interaction with the following proteins:Q9Z1P2 (R-actinin-1), P45592 (Cofilin), Q9QXQ0 (R-actinin-4), P26473 (ADP-ribosylation factor), P26437 (ADP-ribosylation factor),   Q7TNP1 (Basigin 2), Q6P6R2 (Dihydrolipoamide dehydrogenase),   P04797 (GAPDH), Q63081 (Protein disulfide isomerase), P29457 (47 kDa heat shock protein), Q9R1J8 (Leprecan), O88638 (Putative eps protein),   Q64375 (Synaptonemal complex)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:NDPK - Interactions involving proteins containing InterPro domain IPR001564, Nucleoside diphosphate kinase, core.	taxid:10116(rat-l6)|taxid:10116(Rattus norvegicus)	-	2006/02/15	2021/11/30	rogid:PbFY2lfrty8yw40Jq7ShR7xfuV410116	rogid:yyDAbH549UxxQnIHU8uSlGOxsKo10116	intact-crc:44F3A2176D02515F|rigid:9RVm0UBcqQF4k06RGKO89Bg16Q8	false	myc tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P19357	uniprotkb:Q7TPB1	intact:EBI-915426|uniprotkb:P97900|ensembl:ENSRNOP00000023256	intact:EBI-919426|ensembl:ENSRNOP00000012847	psi-mi:glut4_rat(display_long)|uniprotkb:Glucose transporter type 4, insulin-responsive(gene name synonym)|uniprotkb:Slc2a4(gene name)|psi-mi:Slc2a4(display_short)|uniprotkb:Glut4(gene name synonym)	psi-mi:tcpd_rat(display_long)|uniprotkb:Cct4(gene name)|psi-mi:Cct4(display_short)|uniprotkb:CCT-delta(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Foster et al. (2006)	pubmed:16396496|mint:MINT-5218203	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-921030	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2711|refseq:NP_036883.1|refseq:XP_006246658.1|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007611"(learning or memory)|go:"GO:0007614"(short-term memory)|go:"GO:0007616"(long-term memory)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010021"(amylopectin biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031550"(positive regulation of brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044381"(glucose import in response to insulin stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046323"(glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0098694"(regulation of synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0098793"(presynapse)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002441("Glucose transporter, type 4 (GLUT4)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-189200|ensembl:ENSRNOG00000017226(gene)|ensembl:ENSRNOT00000023256(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)	rgd:727937|refseq:NP_877966.1|ensembl:ENSRNOG00000009642(gene)|ensembl:ENSRNOT00000012847(transcript)|go:"GO:0002199"(zona pellucida receptor complex)|go:"GO:0005524"(ATP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005832"(chaperonin-containing T-complex)|go:"GO:0005874"(microtubule)|go:"GO:0005929"(cilium)|go:"GO:0006457"(protein folding)|go:"GO:0007339"(binding of sperm to zona pellucida)|go:"GO:0032212"(positive regulation of telomere maintenance via telomerase)|go:"GO:0042470"(melanosome)|go:"GO:0044183"(protein folding chaperone)|go:"GO:0044297"(cell body)|go:"GO:0050821"(protein stabilization)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051973"(positive regulation of telomerase activity)|go:"GO:0090666"(scaRNA localization to Cajal body)|go:"GO:1901998"(toxin transport)|go:"GO:1904851"(positive regulation of establishment of protein localization to telomere)|go:"GO:1904874"(positive regulation of telomerase RNA localization to Cajal body)|interpro:IPR002194(Chaperonin TCP-1, conserved site)|interpro:IPR002423(Chaperonin Cpn60/TCP-1)|interpro:IPR012717(T-complex protein 1, delta subunit)|interpro:IPR017998|interpro:IPR027409|interpro:IPR027410|interpro:IPR027413|mint:Q7TPB1|reactome:R-RNO-390471|reactome:R-RNO-5620922|reactome:R-RNO-6814122	-	-	-	caution:"The participant EBI-349571(P68370) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919386(Q7TP47) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920972(Q5XIP9) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-916419(P11980) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919578(Q8R491) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920554(Q5U3Z7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920647(Q5U2X8) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920585(Q7TP24) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-779677(P05426) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-915744(P02454) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|agonist:Insulin was shown to increase or decrease GLUT4 protein interactions in specific cases.|comment:"Insulin decreased GLUT4 interactions with the following proteins: Q9ER30 (Sarcosin), P09527 (Rab-7), O88960 (N-ethylmaleimide sensitive), P09456 (PKA I regulatory subunit), P27881 (Hexokinase type II), P07872 (Acyl-coenzyme A oxidase), Q6DGF1 (Isocitrate dehydrogenase), Q9EQX9 (Ubiquitin-conjugating), Q63446 (Polyubiquitin), P24268 (Cathepsin D), Q91XW0 (Heat shock protein 86), Q5FVH0 (unknown), P58405 (Striatin 3), Q62667 (Major vault protein), Q66H50 (unknown), Q09167 (splicing factor), Q9JHU5 (Arfaptin 1)."|comment:"Insulin increased GLUT4 interaction with the following proteins:Q9Z1P2 (R-actinin-1), P45592 (Cofilin), Q9QXQ0 (R-actinin-4), P26473 (ADP-ribosylation factor), P26437 (ADP-ribosylation factor),   Q7TNP1 (Basigin 2), Q6P6R2 (Dihydrolipoamide dehydrogenase),   P04797 (GAPDH), Q63081 (Protein disulfide isomerase), P29457 (47 kDa heat shock protein), Q9R1J8 (Leprecan), O88638 (Putative eps protein),   Q64375 (Synaptonemal complex)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:NDPK - Interactions involving proteins containing InterPro domain IPR001564, Nucleoside diphosphate kinase, core.	taxid:10116(rat-l6)|taxid:10116(Rattus norvegicus)	-	2006/02/15	2021/11/30	rogid:PbFY2lfrty8yw40Jq7ShR7xfuV410116	rogid:xYiR/DP4M2RW1MeQwg2Sb9M77xc10116	intact-crc:44F3A2176D02515F|rigid:9RVm0UBcqQF4k06RGKO89Bg16Q8	false	myc tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P19357	uniprotkb:Q7TP77	intact:EBI-915426|uniprotkb:P97900|ensembl:ENSRNOP00000023256	intact:EBI-919415|ensembl:ENSRNOP00000028475	psi-mi:glut4_rat(display_long)|uniprotkb:Glucose transporter type 4, insulin-responsive(gene name synonym)|uniprotkb:Slc2a4(gene name)|psi-mi:Slc2a4(display_short)|uniprotkb:Glut4(gene name synonym)	psi-mi:q7tp77_rat(display_long)|uniprotkb:Mrpl49(gene name)|psi-mi:Mrpl49(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Foster et al. (2006)	pubmed:16396496|mint:MINT-5218203	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-921030	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2711|refseq:NP_036883.1|refseq:XP_006246658.1|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007611"(learning or memory)|go:"GO:0007614"(short-term memory)|go:"GO:0007616"(long-term memory)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010021"(amylopectin biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031550"(positive regulation of brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044381"(glucose import in response to insulin stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046323"(glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0098694"(regulation of synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0098793"(presynapse)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002441("Glucose transporter, type 4 (GLUT4)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-189200|ensembl:ENSRNOG00000017226(gene)|ensembl:ENSRNOT00000023256(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)	rgd:1309920|refseq:NP_001041348.1|ensembl:ENSRNOG00000020975(gene)|ensembl:ENSRNOT00000028475(transcript)|go:"GO:0003735"(structural constituent of ribosome)|go:"GO:0005739"(mitochondrion)|go:"GO:0005761"(mitochondrial ribosome)|go:"GO:0005762"(mitochondrial large ribosomal subunit)|go:"GO:0006412"(translation)|interpro:IPR007740(Ribosomal protein L49/IMG2)|reactome:R-RNO-5389840|reactome:R-RNO-5419276	-	-	-	caution:"The participant EBI-349571(P68370) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919386(Q7TP47) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920972(Q5XIP9) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-916419(P11980) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919578(Q8R491) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920554(Q5U3Z7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920647(Q5U2X8) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920585(Q7TP24) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-779677(P05426) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-915744(P02454) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|agonist:Insulin was shown to increase or decrease GLUT4 protein interactions in specific cases.|comment:"Insulin decreased GLUT4 interactions with the following proteins: Q9ER30 (Sarcosin), P09527 (Rab-7), O88960 (N-ethylmaleimide sensitive), P09456 (PKA I regulatory subunit), P27881 (Hexokinase type II), P07872 (Acyl-coenzyme A oxidase), Q6DGF1 (Isocitrate dehydrogenase), Q9EQX9 (Ubiquitin-conjugating), Q63446 (Polyubiquitin), P24268 (Cathepsin D), Q91XW0 (Heat shock protein 86), Q5FVH0 (unknown), P58405 (Striatin 3), Q62667 (Major vault protein), Q66H50 (unknown), Q09167 (splicing factor), Q9JHU5 (Arfaptin 1)."|comment:"Insulin increased GLUT4 interaction with the following proteins:Q9Z1P2 (R-actinin-1), P45592 (Cofilin), Q9QXQ0 (R-actinin-4), P26473 (ADP-ribosylation factor), P26437 (ADP-ribosylation factor),   Q7TNP1 (Basigin 2), Q6P6R2 (Dihydrolipoamide dehydrogenase),   P04797 (GAPDH), Q63081 (Protein disulfide isomerase), P29457 (47 kDa heat shock protein), Q9R1J8 (Leprecan), O88638 (Putative eps protein),   Q64375 (Synaptonemal complex)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:NDPK - Interactions involving proteins containing InterPro domain IPR001564, Nucleoside diphosphate kinase, core.	taxid:10116(rat-l6)|taxid:10116(Rattus norvegicus)	-	2006/02/15	2021/11/30	rogid:PbFY2lfrty8yw40Jq7ShR7xfuV410116	rogid:FIT1Uqvt5zXvq4BviqJWvG88oK010116	intact-crc:44F3A2176D02515F|rigid:9RVm0UBcqQF4k06RGKO89Bg16Q8	false	myc tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P19357	uniprotkb:Q7TP72	intact:EBI-915426|uniprotkb:P97900|ensembl:ENSRNOP00000023256	intact:EBI-919411	psi-mi:glut4_rat(display_long)|uniprotkb:Glucose transporter type 4, insulin-responsive(gene name synonym)|uniprotkb:Slc2a4(gene name)|psi-mi:Slc2a4(display_short)|uniprotkb:Glut4(gene name synonym)	psi-mi:q7tp72_rat(display_long)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Foster et al. (2006)	pubmed:16396496|mint:MINT-5218203	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-921030	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2711|refseq:NP_036883.1|refseq:XP_006246658.1|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007611"(learning or memory)|go:"GO:0007614"(short-term memory)|go:"GO:0007616"(long-term memory)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010021"(amylopectin biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031550"(positive regulation of brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044381"(glucose import in response to insulin stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046323"(glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0098694"(regulation of synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0098793"(presynapse)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002441("Glucose transporter, type 4 (GLUT4)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-189200|ensembl:ENSRNOG00000017226(gene)|ensembl:ENSRNOT00000023256(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)	interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR001680(WD40 repeat)|interpro:IPR036322	-	-	-	caution:"The participant EBI-349571(P68370) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919386(Q7TP47) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920972(Q5XIP9) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-916419(P11980) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919578(Q8R491) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920554(Q5U3Z7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920647(Q5U2X8) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920585(Q7TP24) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-779677(P05426) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-915744(P02454) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|agonist:Insulin was shown to increase or decrease GLUT4 protein interactions in specific cases.|comment:"Insulin decreased GLUT4 interactions with the following proteins: Q9ER30 (Sarcosin), P09527 (Rab-7), O88960 (N-ethylmaleimide sensitive), P09456 (PKA I regulatory subunit), P27881 (Hexokinase type II), P07872 (Acyl-coenzyme A oxidase), Q6DGF1 (Isocitrate dehydrogenase), Q9EQX9 (Ubiquitin-conjugating), Q63446 (Polyubiquitin), P24268 (Cathepsin D), Q91XW0 (Heat shock protein 86), Q5FVH0 (unknown), P58405 (Striatin 3), Q62667 (Major vault protein), Q66H50 (unknown), Q09167 (splicing factor), Q9JHU5 (Arfaptin 1)."|comment:"Insulin increased GLUT4 interaction with the following proteins:Q9Z1P2 (R-actinin-1), P45592 (Cofilin), Q9QXQ0 (R-actinin-4), P26473 (ADP-ribosylation factor), P26437 (ADP-ribosylation factor),   Q7TNP1 (Basigin 2), Q6P6R2 (Dihydrolipoamide dehydrogenase),   P04797 (GAPDH), Q63081 (Protein disulfide isomerase), P29457 (47 kDa heat shock protein), Q9R1J8 (Leprecan), O88638 (Putative eps protein),   Q64375 (Synaptonemal complex)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:NDPK - Interactions involving proteins containing InterPro domain IPR001564, Nucleoside diphosphate kinase, core.	taxid:10116(rat-l6)|taxid:10116(Rattus norvegicus)	-	2006/02/15	2021/11/30	rogid:PbFY2lfrty8yw40Jq7ShR7xfuV410116	rogid:w24Ge5unIOj+XSckTZFQFUWVVzc10116	intact-crc:44F3A2176D02515F|rigid:9RVm0UBcqQF4k06RGKO89Bg16Q8	false	myc tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P19357	uniprotkb:Q7TP59	intact:EBI-915426|uniprotkb:P97900|ensembl:ENSRNOP00000023256	intact:EBI-919408	psi-mi:glut4_rat(display_long)|uniprotkb:Glucose transporter type 4, insulin-responsive(gene name synonym)|uniprotkb:Slc2a4(gene name)|psi-mi:Slc2a4(display_short)|uniprotkb:Glut4(gene name synonym)	psi-mi:q7tp59_rat(display_long)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Foster et al. (2006)	pubmed:16396496|mint:MINT-5218203	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-921030	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2711|refseq:NP_036883.1|refseq:XP_006246658.1|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007611"(learning or memory)|go:"GO:0007614"(short-term memory)|go:"GO:0007616"(long-term memory)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010021"(amylopectin biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031550"(positive regulation of brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044381"(glucose import in response to insulin stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046323"(glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0098694"(regulation of synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0098793"(presynapse)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002441("Glucose transporter, type 4 (GLUT4)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-189200|ensembl:ENSRNOG00000017226(gene)|ensembl:ENSRNOT00000023256(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)	interpro:IPR022049|interpro:IPR020519|go:"GO:0005576"(extracellular region)	-	-	-	caution:"The participant EBI-349571(P68370) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919386(Q7TP47) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920972(Q5XIP9) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-916419(P11980) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919578(Q8R491) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920554(Q5U3Z7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920647(Q5U2X8) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920585(Q7TP24) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-779677(P05426) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-915744(P02454) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|agonist:Insulin was shown to increase or decrease GLUT4 protein interactions in specific cases.|comment:"Insulin decreased GLUT4 interactions with the following proteins: Q9ER30 (Sarcosin), P09527 (Rab-7), O88960 (N-ethylmaleimide sensitive), P09456 (PKA I regulatory subunit), P27881 (Hexokinase type II), P07872 (Acyl-coenzyme A oxidase), Q6DGF1 (Isocitrate dehydrogenase), Q9EQX9 (Ubiquitin-conjugating), Q63446 (Polyubiquitin), P24268 (Cathepsin D), Q91XW0 (Heat shock protein 86), Q5FVH0 (unknown), P58405 (Striatin 3), Q62667 (Major vault protein), Q66H50 (unknown), Q09167 (splicing factor), Q9JHU5 (Arfaptin 1)."|comment:"Insulin increased GLUT4 interaction with the following proteins:Q9Z1P2 (R-actinin-1), P45592 (Cofilin), Q9QXQ0 (R-actinin-4), P26473 (ADP-ribosylation factor), P26437 (ADP-ribosylation factor),   Q7TNP1 (Basigin 2), Q6P6R2 (Dihydrolipoamide dehydrogenase),   P04797 (GAPDH), Q63081 (Protein disulfide isomerase), P29457 (47 kDa heat shock protein), Q9R1J8 (Leprecan), O88638 (Putative eps protein),   Q64375 (Synaptonemal complex)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:NDPK - Interactions involving proteins containing InterPro domain IPR001564, Nucleoside diphosphate kinase, core.	taxid:10116(rat-l6)|taxid:10116(Rattus norvegicus)	-	2006/02/15	2021/11/30	rogid:PbFY2lfrty8yw40Jq7ShR7xfuV410116	rogid:ceBHpWWm/IZ/Q25MbzZjI+UvQqU10116	intact-crc:44F3A2176D02515F|rigid:9RVm0UBcqQF4k06RGKO89Bg16Q8	false	myc tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P19357	uniprotkb:Q7TP54	intact:EBI-915426|uniprotkb:P97900|ensembl:ENSRNOP00000023256	intact:EBI-919395|ensembl:ENSRNOP00000048390	psi-mi:glut4_rat(display_long)|uniprotkb:Glucose transporter type 4, insulin-responsive(gene name synonym)|uniprotkb:Slc2a4(gene name)|psi-mi:Slc2a4(display_short)|uniprotkb:Glut4(gene name synonym)	psi-mi:ripr2_rat(display_long)|uniprotkb:Ripor2(gene name)|psi-mi:Ripor2(display_short)|uniprotkb:Fam65b(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Foster et al. (2006)	pubmed:16396496|mint:MINT-5218203	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-921030	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2711|refseq:NP_036883.1|refseq:XP_006246658.1|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007611"(learning or memory)|go:"GO:0007614"(short-term memory)|go:"GO:0007616"(long-term memory)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010021"(amylopectin biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031550"(positive regulation of brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044381"(glucose import in response to insulin stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046323"(glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0098694"(regulation of synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0098793"(presynapse)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002441("Glucose transporter, type 4 (GLUT4)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-189200|ensembl:ENSRNOG00000017226(gene)|ensembl:ENSRNOT00000023256(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)	rgd:1306939|refseq:NP_001014031.2|ensembl:ENSRNOG00000018804(gene)|ensembl:ENSRNOT00000048298(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006935"(chemotaxis)|go:"GO:0007155"(cell adhesion)|go:"GO:0007162"(negative regulation of cell adhesion)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0008199"(ferric iron binding)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0030175"(filopodium)|go:"GO:0032420"(stereocilium)|go:"GO:0035024"(negative regulation of Rho protein signal transduction)|go:"GO:0042802"(identical protein binding)|go:"GO:0045184"(establishment of protein localization)|go:"GO:0045663"(positive regulation of myoblast differentiation)|go:"GO:0048741"(skeletal muscle fiber development)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0060088"(auditory receptor cell stereocilium organization)|go:"GO:0060171"(stereocilium membrane)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071889"(14-3-3 protein binding)|go:"GO:0090023"(positive regulation of neutrophil chemotaxis)|go:"GO:1901741"(positive regulation of myoblast fusion)|go:"GO:1903904"(negative regulation of establishment of T cell polarity)|go:"GO:1905872"(negative regulation of protein localization to cell leading edge)|go:"GO:1990869"(cellular response to chemokine)|go:"GO:2000114"(regulation of establishment of cell polarity)|go:"GO:2000391"(positive regulation of neutrophil extravasation)|go:"GO:2000405"(negative regulation of T cell migration)|go:"GO:2001107"(negative regulation of Rho guanyl-nucleotide exchange factor activity)|interpro:IPR008331(Ferritin and Dps)|interpro:IPR009040(Ferritin-like)|interpro:IPR009078(Ferritin/ribonucleotide reductase-like)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR012347(Ferritin-related)|interpro:IPR014034(Ferritin, conserved site)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR026136|interpro:IPR031780|interpro:IPR033035|mint:Q7TP54	-	-	-	caution:"The participant EBI-349571(P68370) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919386(Q7TP47) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920972(Q5XIP9) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-916419(P11980) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919578(Q8R491) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920554(Q5U3Z7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920647(Q5U2X8) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920585(Q7TP24) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-779677(P05426) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-915744(P02454) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|agonist:Insulin was shown to increase or decrease GLUT4 protein interactions in specific cases.|comment:"Insulin decreased GLUT4 interactions with the following proteins: Q9ER30 (Sarcosin), P09527 (Rab-7), O88960 (N-ethylmaleimide sensitive), P09456 (PKA I regulatory subunit), P27881 (Hexokinase type II), P07872 (Acyl-coenzyme A oxidase), Q6DGF1 (Isocitrate dehydrogenase), Q9EQX9 (Ubiquitin-conjugating), Q63446 (Polyubiquitin), P24268 (Cathepsin D), Q91XW0 (Heat shock protein 86), Q5FVH0 (unknown), P58405 (Striatin 3), Q62667 (Major vault protein), Q66H50 (unknown), Q09167 (splicing factor), Q9JHU5 (Arfaptin 1)."|comment:"Insulin increased GLUT4 interaction with the following proteins:Q9Z1P2 (R-actinin-1), P45592 (Cofilin), Q9QXQ0 (R-actinin-4), P26473 (ADP-ribosylation factor), P26437 (ADP-ribosylation factor),   Q7TNP1 (Basigin 2), Q6P6R2 (Dihydrolipoamide dehydrogenase),   P04797 (GAPDH), Q63081 (Protein disulfide isomerase), P29457 (47 kDa heat shock protein), Q9R1J8 (Leprecan), O88638 (Putative eps protein),   Q64375 (Synaptonemal complex)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:NDPK - Interactions involving proteins containing InterPro domain IPR001564, Nucleoside diphosphate kinase, core.	taxid:10116(rat-l6)|taxid:10116(Rattus norvegicus)	-	2006/02/15	2021/11/30	rogid:PbFY2lfrty8yw40Jq7ShR7xfuV410116	rogid:zAWBRTkBC4dEJtAjlITb2T4kPAY10116	intact-crc:44F3A2176D02515F|rigid:9RVm0UBcqQF4k06RGKO89Bg16Q8	false	myc tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P19357	uniprotkb:Q7TP34	intact:EBI-915426|uniprotkb:P97900|ensembl:ENSRNOP00000023256	intact:EBI-919376|ensembl:ENSRNOP00000075327	psi-mi:glut4_rat(display_long)|uniprotkb:Glucose transporter type 4, insulin-responsive(gene name synonym)|uniprotkb:Slc2a4(gene name)|psi-mi:Slc2a4(display_short)|uniprotkb:Glut4(gene name synonym)	psi-mi:q7tp34_rat(display_long)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Foster et al. (2006)	pubmed:16396496|mint:MINT-5218203	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-921030	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2711|refseq:NP_036883.1|refseq:XP_006246658.1|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007611"(learning or memory)|go:"GO:0007614"(short-term memory)|go:"GO:0007616"(long-term memory)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010021"(amylopectin biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031550"(positive regulation of brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044381"(glucose import in response to insulin stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046323"(glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0098694"(regulation of synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0098793"(presynapse)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002441("Glucose transporter, type 4 (GLUT4)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-189200|ensembl:ENSRNOG00000017226(gene)|ensembl:ENSRNOT00000023256(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)	ensembl:ENSRNOG00000056162(gene)|ensembl:ENSRNOT00000088221(transcript)|go:"GO:0004559"(alpha-mannosidase activity)|go:"GO:0005764"(lysosome)|go:"GO:0005774"(vacuolar membrane)|go:"GO:0006013"(mannose metabolic process)|go:"GO:0030246"(carbohydrate binding)|go:"GO:0046872"(metal ion binding)|interpro:IPR000602(Glycoside hydrolase, family 38, core)|interpro:IPR011013(Glycoside hydrolase-type carbohydrate-binding)|interpro:IPR011330(Glycoside hydrolase/deacetylase, beta/alpha-barrel)|interpro:IPR011682(Glycosyl hydrolases 38, C-terminal)|interpro:IPR013780(Glycosyl hydrolase, family 13, all-beta)|interpro:IPR015341(Glycoside hydrolase, family 38, central region)|interpro:IPR027291|interpro:IPR028995|interpro:IPR029254|interpro:IPR037094	-	-	-	caution:"The participant EBI-349571(P68370) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919386(Q7TP47) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920972(Q5XIP9) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-916419(P11980) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919578(Q8R491) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920554(Q5U3Z7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920647(Q5U2X8) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920585(Q7TP24) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-779677(P05426) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-915744(P02454) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|agonist:Insulin was shown to increase or decrease GLUT4 protein interactions in specific cases.|comment:"Insulin decreased GLUT4 interactions with the following proteins: Q9ER30 (Sarcosin), P09527 (Rab-7), O88960 (N-ethylmaleimide sensitive), P09456 (PKA I regulatory subunit), P27881 (Hexokinase type II), P07872 (Acyl-coenzyme A oxidase), Q6DGF1 (Isocitrate dehydrogenase), Q9EQX9 (Ubiquitin-conjugating), Q63446 (Polyubiquitin), P24268 (Cathepsin D), Q91XW0 (Heat shock protein 86), Q5FVH0 (unknown), P58405 (Striatin 3), Q62667 (Major vault protein), Q66H50 (unknown), Q09167 (splicing factor), Q9JHU5 (Arfaptin 1)."|comment:"Insulin increased GLUT4 interaction with the following proteins:Q9Z1P2 (R-actinin-1), P45592 (Cofilin), Q9QXQ0 (R-actinin-4), P26473 (ADP-ribosylation factor), P26437 (ADP-ribosylation factor),   Q7TNP1 (Basigin 2), Q6P6R2 (Dihydrolipoamide dehydrogenase),   P04797 (GAPDH), Q63081 (Protein disulfide isomerase), P29457 (47 kDa heat shock protein), Q9R1J8 (Leprecan), O88638 (Putative eps protein),   Q64375 (Synaptonemal complex)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:NDPK - Interactions involving proteins containing InterPro domain IPR001564, Nucleoside diphosphate kinase, core.	taxid:10116(rat-l6)|taxid:10116(Rattus norvegicus)	-	2006/02/15	2021/11/30	rogid:PbFY2lfrty8yw40Jq7ShR7xfuV410116	rogid:1gen1+pit/YjE/JbQrjSKGLcrTY10116	intact-crc:44F3A2176D02515F|rigid:9RVm0UBcqQF4k06RGKO89Bg16Q8	false	myc tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P19357	uniprotkb:Q7TP13	intact:EBI-915426|uniprotkb:P97900|ensembl:ENSRNOP00000023256	intact:EBI-919370|ensembl:ENSRNOP00000071498	psi-mi:glut4_rat(display_long)|uniprotkb:Glucose transporter type 4, insulin-responsive(gene name synonym)|uniprotkb:Slc2a4(gene name)|psi-mi:Slc2a4(display_short)|uniprotkb:Glut4(gene name synonym)	psi-mi:q7tp13_rat(display_long)|uniprotkb:Gpt2(gene name)|psi-mi:Gpt2(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Foster et al. (2006)	pubmed:16396496|mint:MINT-5218203	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-921030	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2711|refseq:NP_036883.1|refseq:XP_006246658.1|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007611"(learning or memory)|go:"GO:0007614"(short-term memory)|go:"GO:0007616"(long-term memory)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010021"(amylopectin biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031550"(positive regulation of brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044381"(glucose import in response to insulin stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046323"(glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0098694"(regulation of synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0098793"(presynapse)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002441("Glucose transporter, type 4 (GLUT4)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-189200|ensembl:ENSRNOG00000017226(gene)|ensembl:ENSRNOT00000023256(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)	rgd:1305462|ensembl:ENSRNOG00000059579(gene)|ensembl:ENSRNOT00000078348(transcript)|go:"GO:0004021"("L-alanine:2-oxoglutarate aminotransferase activity")|go:"GO:0005615"(extracellular space)|go:"GO:0005739"(mitochondrion)|go:"GO:0006103"(2-oxoglutarate metabolic process)|go:"GO:0009058"(biosynthetic process)|go:"GO:0030170"(pyridoxal phosphate binding)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0033574"(response to testosterone)|go:"GO:0042594"(response to starvation)|go:"GO:0042851"(L-alanine metabolic process)|go:"GO:0045722"(positive regulation of gluconeogenesis)|interpro:IPR004839(Aminotransferase, class I and II)|interpro:IPR015421(Pyridoxal phosphate-dependent transferase, major region, subdomain 1)|interpro:IPR015422(Pyridoxal phosphate-dependent transferase, major region, subdomain 2)|interpro:IPR015424(Pyridoxal phosphate-dependent transferase, major region)|reactome:R-RNO-8964540	-	-	-	caution:"The participant EBI-349571(P68370) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919386(Q7TP47) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920972(Q5XIP9) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-916419(P11980) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919578(Q8R491) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920554(Q5U3Z7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920647(Q5U2X8) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920585(Q7TP24) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-779677(P05426) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-915744(P02454) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|agonist:Insulin was shown to increase or decrease GLUT4 protein interactions in specific cases.|comment:"Insulin decreased GLUT4 interactions with the following proteins: Q9ER30 (Sarcosin), P09527 (Rab-7), O88960 (N-ethylmaleimide sensitive), P09456 (PKA I regulatory subunit), P27881 (Hexokinase type II), P07872 (Acyl-coenzyme A oxidase), Q6DGF1 (Isocitrate dehydrogenase), Q9EQX9 (Ubiquitin-conjugating), Q63446 (Polyubiquitin), P24268 (Cathepsin D), Q91XW0 (Heat shock protein 86), Q5FVH0 (unknown), P58405 (Striatin 3), Q62667 (Major vault protein), Q66H50 (unknown), Q09167 (splicing factor), Q9JHU5 (Arfaptin 1)."|comment:"Insulin increased GLUT4 interaction with the following proteins:Q9Z1P2 (R-actinin-1), P45592 (Cofilin), Q9QXQ0 (R-actinin-4), P26473 (ADP-ribosylation factor), P26437 (ADP-ribosylation factor),   Q7TNP1 (Basigin 2), Q6P6R2 (Dihydrolipoamide dehydrogenase),   P04797 (GAPDH), Q63081 (Protein disulfide isomerase), P29457 (47 kDa heat shock protein), Q9R1J8 (Leprecan), O88638 (Putative eps protein),   Q64375 (Synaptonemal complex)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:NDPK - Interactions involving proteins containing InterPro domain IPR001564, Nucleoside diphosphate kinase, core.	taxid:10116(rat-l6)|taxid:10116(Rattus norvegicus)	-	2006/02/15	2021/11/30	rogid:PbFY2lfrty8yw40Jq7ShR7xfuV410116	rogid:dYqGf7n55pIruHc0RYfTHFRuL4U10116	intact-crc:44F3A2176D02515F|rigid:9RVm0UBcqQF4k06RGKO89Bg16Q8	false	myc tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P19357	uniprotkb:Q7TP11	intact:EBI-915426|uniprotkb:P97900|ensembl:ENSRNOP00000023256	intact:EBI-919352	psi-mi:glut4_rat(display_long)|uniprotkb:Glucose transporter type 4, insulin-responsive(gene name synonym)|uniprotkb:Slc2a4(gene name)|psi-mi:Slc2a4(display_short)|uniprotkb:Glut4(gene name synonym)	psi-mi:q7tp11_rat(display_long)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Foster et al. (2006)	pubmed:16396496|mint:MINT-5218203	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-921030	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2711|refseq:NP_036883.1|refseq:XP_006246658.1|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007611"(learning or memory)|go:"GO:0007614"(short-term memory)|go:"GO:0007616"(long-term memory)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010021"(amylopectin biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031550"(positive regulation of brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044381"(glucose import in response to insulin stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046323"(glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0098694"(regulation of synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0098793"(presynapse)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002441("Glucose transporter, type 4 (GLUT4)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-189200|ensembl:ENSRNOG00000017226(gene)|ensembl:ENSRNOT00000023256(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)	interpro:IPR029003|interpro:IPR008927(6-phosphogluconate dehydrogenase, C-terminal-like)|interpro:IPR006114(6-phosphogluconate dehydrogenase, C-terminal)|interpro:IPR006113(6-phosphogluconate dehydrogenase, decarboxylating)|interpro:IPR006115(6-phosphogluconate dehydrogenase, NAD-binding)|interpro:IPR006184(6-phosphogluconate-binding site)|interpro:IPR013328(Dehydrogenase, multihelical)|interpro:IPR009072(Histone-fold)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR006183(6-phosphogluconate dehydrogenase)|interpro:IPR036291|go:"GO:0004616"("phosphogluconate dehydrogenase (decarboxylating) activity")|go:"GO:0006098"(pentose-phosphate shunt)|go:"GO:0006281"(DNA repair)|go:"GO:0019521"(D-gluconate metabolic process)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0050661"(NADP binding)|go:"GO:0071821"(FANCM-MHF complex)	-	-	-	caution:"The participant EBI-349571(P68370) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919386(Q7TP47) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920972(Q5XIP9) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-916419(P11980) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919578(Q8R491) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920554(Q5U3Z7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920647(Q5U2X8) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920585(Q7TP24) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-779677(P05426) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-915744(P02454) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|agonist:Insulin was shown to increase or decrease GLUT4 protein interactions in specific cases.|comment:"Insulin decreased GLUT4 interactions with the following proteins: Q9ER30 (Sarcosin), P09527 (Rab-7), O88960 (N-ethylmaleimide sensitive), P09456 (PKA I regulatory subunit), P27881 (Hexokinase type II), P07872 (Acyl-coenzyme A oxidase), Q6DGF1 (Isocitrate dehydrogenase), Q9EQX9 (Ubiquitin-conjugating), Q63446 (Polyubiquitin), P24268 (Cathepsin D), Q91XW0 (Heat shock protein 86), Q5FVH0 (unknown), P58405 (Striatin 3), Q62667 (Major vault protein), Q66H50 (unknown), Q09167 (splicing factor), Q9JHU5 (Arfaptin 1)."|comment:"Insulin increased GLUT4 interaction with the following proteins:Q9Z1P2 (R-actinin-1), P45592 (Cofilin), Q9QXQ0 (R-actinin-4), P26473 (ADP-ribosylation factor), P26437 (ADP-ribosylation factor),   Q7TNP1 (Basigin 2), Q6P6R2 (Dihydrolipoamide dehydrogenase),   P04797 (GAPDH), Q63081 (Protein disulfide isomerase), P29457 (47 kDa heat shock protein), Q9R1J8 (Leprecan), O88638 (Putative eps protein),   Q64375 (Synaptonemal complex)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:NDPK - Interactions involving proteins containing InterPro domain IPR001564, Nucleoside diphosphate kinase, core.	taxid:10116(rat-l6)|taxid:10116(Rattus norvegicus)	-	2006/02/15	2021/11/30	rogid:PbFY2lfrty8yw40Jq7ShR7xfuV410116	rogid:9RWd+Os3miiEXaOJptxA7MjF3AI10116	intact-crc:44F3A2176D02515F|rigid:9RVm0UBcqQF4k06RGKO89Bg16Q8	false	myc tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P19357	uniprotkb:Q7TP08	intact:EBI-915426|uniprotkb:P97900|ensembl:ENSRNOP00000023256	intact:EBI-919346|ensembl:ENSRNOP00000040100	psi-mi:glut4_rat(display_long)|uniprotkb:Glucose transporter type 4, insulin-responsive(gene name synonym)|uniprotkb:Slc2a4(gene name)|psi-mi:Slc2a4(display_short)|uniprotkb:Glut4(gene name synonym)	psi-mi:q7tp08_rat(display_long)|uniprotkb:Amacr(gene name)|psi-mi:Amacr(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Foster et al. (2006)	pubmed:16396496|mint:MINT-5218203	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-921030	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2711|refseq:NP_036883.1|refseq:XP_006246658.1|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007611"(learning or memory)|go:"GO:0007614"(short-term memory)|go:"GO:0007616"(long-term memory)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010021"(amylopectin biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031550"(positive regulation of brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044381"(glucose import in response to insulin stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046323"(glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0098694"(regulation of synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0098793"(presynapse)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002441("Glucose transporter, type 4 (GLUT4)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-189200|ensembl:ENSRNOG00000017226(gene)|ensembl:ENSRNOT00000023256(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)	rgd:3048|ensembl:ENSRNOG00000018662(gene)|ensembl:ENSRNOT00000040701(transcript)|go:"GO:0005739"(mitochondrion)|go:"GO:0005777"(peroxisome)|go:"GO:0005886"(plasma membrane)|go:"GO:0008111"(alpha-methylacyl-CoA racemase activity)|go:"GO:0008206"(bile acid metabolic process)|go:"GO:0008410"(CoA-transferase activity)|interpro:IPR003673(CoA-transferase family III)|interpro:IPR023606|interpro:IPR044855	-	-	-	caution:"The participant EBI-349571(P68370) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919386(Q7TP47) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920972(Q5XIP9) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-916419(P11980) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919578(Q8R491) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920554(Q5U3Z7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920647(Q5U2X8) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920585(Q7TP24) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-779677(P05426) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-915744(P02454) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|agonist:Insulin was shown to increase or decrease GLUT4 protein interactions in specific cases.|comment:"Insulin decreased GLUT4 interactions with the following proteins: Q9ER30 (Sarcosin), P09527 (Rab-7), O88960 (N-ethylmaleimide sensitive), P09456 (PKA I regulatory subunit), P27881 (Hexokinase type II), P07872 (Acyl-coenzyme A oxidase), Q6DGF1 (Isocitrate dehydrogenase), Q9EQX9 (Ubiquitin-conjugating), Q63446 (Polyubiquitin), P24268 (Cathepsin D), Q91XW0 (Heat shock protein 86), Q5FVH0 (unknown), P58405 (Striatin 3), Q62667 (Major vault protein), Q66H50 (unknown), Q09167 (splicing factor), Q9JHU5 (Arfaptin 1)."|comment:"Insulin increased GLUT4 interaction with the following proteins:Q9Z1P2 (R-actinin-1), P45592 (Cofilin), Q9QXQ0 (R-actinin-4), P26473 (ADP-ribosylation factor), P26437 (ADP-ribosylation factor),   Q7TNP1 (Basigin 2), Q6P6R2 (Dihydrolipoamide dehydrogenase),   P04797 (GAPDH), Q63081 (Protein disulfide isomerase), P29457 (47 kDa heat shock protein), Q9R1J8 (Leprecan), O88638 (Putative eps protein),   Q64375 (Synaptonemal complex)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:NDPK - Interactions involving proteins containing InterPro domain IPR001564, Nucleoside diphosphate kinase, core.	taxid:10116(rat-l6)|taxid:10116(Rattus norvegicus)	-	2006/02/15	2021/11/30	rogid:PbFY2lfrty8yw40Jq7ShR7xfuV410116	rogid:DmuuHclLauWLM+AS46B7bOcFJA810116	intact-crc:44F3A2176D02515F|rigid:9RVm0UBcqQF4k06RGKO89Bg16Q8	false	myc tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P19357	uniprotkb:P26453	intact:EBI-915426|uniprotkb:P97900|ensembl:ENSRNOP00000023256	intact:EBI-919328|uniprotkb:Q7TNP1|ensembl:ENSRNOP00000011275	psi-mi:glut4_rat(display_long)|uniprotkb:Glucose transporter type 4, insulin-responsive(gene name synonym)|uniprotkb:Slc2a4(gene name)|psi-mi:Slc2a4(display_short)|uniprotkb:Glut4(gene name synonym)	psi-mi:basi_rat(display_long)|uniprotkb:Bsg(gene name)|psi-mi:Bsg(display_short)|uniprotkb:OX-47 antigen(gene name synonym)|uniprotkb:Glycoprotein CE9(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Foster et al. (2006)	pubmed:16396496|mint:MINT-5218203	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-921030	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2711|refseq:NP_036883.1|refseq:XP_006246658.1|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007611"(learning or memory)|go:"GO:0007614"(short-term memory)|go:"GO:0007616"(long-term memory)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010021"(amylopectin biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031550"(positive regulation of brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044381"(glucose import in response to insulin stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046323"(glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0098694"(regulation of synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0098793"(presynapse)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002441("Glucose transporter, type 4 (GLUT4)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-189200|ensembl:ENSRNOG00000017226(gene)|ensembl:ENSRNOT00000023256(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)	rgd:2220|refseq:NP_001103352.1|refseq:NP_036915.1|ensembl:ENSRNOG00000008414(gene)|ensembl:ENSRNOT00000011275(transcript)|go:"GO:0001750"(photoreceptor outer segment)|go:"GO:0001917"(photoreceptor inner segment)|go:"GO:0002080"(acrosomal membrane)|go:"GO:0003407"(neural retina development)|go:"GO:0005537"(mannose binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007156"(homophilic cell adhesion via plasma membrane adhesion molecules)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007411"(axon guidance)|go:"GO:0007566"(embryo implantation)|go:"GO:0010575"(positive regulation of vascular endothelial growth factor production)|go:"GO:0010595"(positive regulation of endothelial cell migration)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0030424"(axon)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042383"(sarcolemma)|go:"GO:0042475"(odontogenesis of dentin-containing tooth)|go:"GO:0043434"(response to peptide hormone)|go:"GO:0045121"(membrane raft)|go:"GO:0045494"(photoreceptor cell maintenance)|go:"GO:0046689"(response to mercury ion)|go:"GO:0046697"(decidualization)|go:"GO:0051591"(response to cAMP)|go:"GO:0061154"(endothelial tube morphogenesis)|go:"GO:0070593"(dendrite self-avoidance)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0098632"(cell-cell adhesion mediator activity)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|interpro:IPR043204|interpro:IPR044157|reactome:R-RNO-1474228|reactome:R-RNO-210991|reactome:R-RNO-216083|reactome:R-RNO-433692|reactome:R-RNO-70268	-	-	-	caution:"The participant EBI-349571(P68370) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919386(Q7TP47) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920972(Q5XIP9) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-916419(P11980) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919578(Q8R491) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920554(Q5U3Z7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920647(Q5U2X8) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920585(Q7TP24) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-779677(P05426) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-915744(P02454) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|agonist:Insulin was shown to increase or decrease GLUT4 protein interactions in specific cases.|comment:"Insulin decreased GLUT4 interactions with the following proteins: Q9ER30 (Sarcosin), P09527 (Rab-7), O88960 (N-ethylmaleimide sensitive), P09456 (PKA I regulatory subunit), P27881 (Hexokinase type II), P07872 (Acyl-coenzyme A oxidase), Q6DGF1 (Isocitrate dehydrogenase), Q9EQX9 (Ubiquitin-conjugating), Q63446 (Polyubiquitin), P24268 (Cathepsin D), Q91XW0 (Heat shock protein 86), Q5FVH0 (unknown), P58405 (Striatin 3), Q62667 (Major vault protein), Q66H50 (unknown), Q09167 (splicing factor), Q9JHU5 (Arfaptin 1)."|comment:"Insulin increased GLUT4 interaction with the following proteins:Q9Z1P2 (R-actinin-1), P45592 (Cofilin), Q9QXQ0 (R-actinin-4), P26473 (ADP-ribosylation factor), P26437 (ADP-ribosylation factor),   Q7TNP1 (Basigin 2), Q6P6R2 (Dihydrolipoamide dehydrogenase),   P04797 (GAPDH), Q63081 (Protein disulfide isomerase), P29457 (47 kDa heat shock protein), Q9R1J8 (Leprecan), O88638 (Putative eps protein),   Q64375 (Synaptonemal complex)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:NDPK - Interactions involving proteins containing InterPro domain IPR001564, Nucleoside diphosphate kinase, core.	taxid:10116(rat-l6)|taxid:10116(Rattus norvegicus)	-	2006/02/15	2021/11/30	rogid:PbFY2lfrty8yw40Jq7ShR7xfuV410116	rogid:7T4ZJgmAX0bkcRSzDz2iSX1xSEc10116	intact-crc:44F3A2176D02515F|rigid:9RVm0UBcqQF4k06RGKO89Bg16Q8	false	myc tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P19357	uniprotkb:Q7M0E3	intact:EBI-915426|uniprotkb:P97900|ensembl:ENSRNOP00000023256	intact:EBI-919323|ensembl:ENSRNOP00000007794	psi-mi:glut4_rat(display_long)|uniprotkb:Glucose transporter type 4, insulin-responsive(gene name synonym)|uniprotkb:Slc2a4(gene name)|psi-mi:Slc2a4(display_short)|uniprotkb:Glut4(gene name synonym)	psi-mi:dest_rat(display_long)|uniprotkb:Dstn(gene name)|psi-mi:Dstn(display_short)|uniprotkb:Actin-depolymerizing factor(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Foster et al. (2006)	pubmed:16396496|mint:MINT-5218203	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-921030	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2711|refseq:NP_036883.1|refseq:XP_006246658.1|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007611"(learning or memory)|go:"GO:0007614"(short-term memory)|go:"GO:0007616"(long-term memory)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010021"(amylopectin biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031550"(positive regulation of brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044381"(glucose import in response to insulin stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046323"(glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0098694"(regulation of synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0098793"(presynapse)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002441("Glucose transporter, type 4 (GLUT4)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-189200|ensembl:ENSRNOG00000017226(gene)|ensembl:ENSRNOT00000023256(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)	rgd:1588366|refseq:NP_001028838.1|ensembl:ENSRNOG00000005924(gene)|ensembl:ENSRNOT00000007794(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0030042"(actin filament depolymerization)|go:"GO:0030043"(actin filament fragmentation)|go:"GO:0030836"(positive regulation of actin filament depolymerization)|go:"GO:0030864"(cortical actin cytoskeleton)|go:"GO:0048870"(cell motility)|go:"GO:0051014"(actin filament severing)|go:"GO:0051015"(actin filament binding)|interpro:IPR002108(Actin-binding, cofilin/tropomyosin type)|interpro:IPR017904|interpro:IPR029006|interpro:IPR029924	-	-	-	caution:"The participant EBI-349571(P68370) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919386(Q7TP47) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920972(Q5XIP9) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-916419(P11980) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919578(Q8R491) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920554(Q5U3Z7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920647(Q5U2X8) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920585(Q7TP24) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-779677(P05426) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-915744(P02454) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|agonist:Insulin was shown to increase or decrease GLUT4 protein interactions in specific cases.|comment:"Insulin decreased GLUT4 interactions with the following proteins: Q9ER30 (Sarcosin), P09527 (Rab-7), O88960 (N-ethylmaleimide sensitive), P09456 (PKA I regulatory subunit), P27881 (Hexokinase type II), P07872 (Acyl-coenzyme A oxidase), Q6DGF1 (Isocitrate dehydrogenase), Q9EQX9 (Ubiquitin-conjugating), Q63446 (Polyubiquitin), P24268 (Cathepsin D), Q91XW0 (Heat shock protein 86), Q5FVH0 (unknown), P58405 (Striatin 3), Q62667 (Major vault protein), Q66H50 (unknown), Q09167 (splicing factor), Q9JHU5 (Arfaptin 1)."|comment:"Insulin increased GLUT4 interaction with the following proteins:Q9Z1P2 (R-actinin-1), P45592 (Cofilin), Q9QXQ0 (R-actinin-4), P26473 (ADP-ribosylation factor), P26437 (ADP-ribosylation factor),   Q7TNP1 (Basigin 2), Q6P6R2 (Dihydrolipoamide dehydrogenase),   P04797 (GAPDH), Q63081 (Protein disulfide isomerase), P29457 (47 kDa heat shock protein), Q9R1J8 (Leprecan), O88638 (Putative eps protein),   Q64375 (Synaptonemal complex)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:NDPK - Interactions involving proteins containing InterPro domain IPR001564, Nucleoside diphosphate kinase, core.	taxid:10116(rat-l6)|taxid:10116(Rattus norvegicus)	-	2006/02/15	2021/11/30	rogid:PbFY2lfrty8yw40Jq7ShR7xfuV410116	rogid:B0ITNRHuiy9QxPKM8bB5HVq8pPg10116	intact-crc:44F3A2176D02515F|rigid:9RVm0UBcqQF4k06RGKO89Bg16Q8	false	myc tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P19357	uniprotkb:Q794E4	intact:EBI-915426|uniprotkb:P97900|ensembl:ENSRNOP00000023256	intact:EBI-919306|ensembl:ENSRNOP00000019529|ensembl:ENSRNOP00000068652|ensembl:ENSRNOP00000069655	psi-mi:glut4_rat(display_long)|uniprotkb:Glucose transporter type 4, insulin-responsive(gene name synonym)|uniprotkb:Slc2a4(gene name)|psi-mi:Slc2a4(display_short)|uniprotkb:Glut4(gene name synonym)	psi-mi:hnrpf_rat(display_long)|uniprotkb:Hnrnpf(gene name)|psi-mi:Hnrnpf(display_short)|uniprotkb:Hnrpf(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Foster et al. (2006)	pubmed:16396496|mint:MINT-5218203	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-921030	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2711|refseq:NP_036883.1|refseq:XP_006246658.1|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007611"(learning or memory)|go:"GO:0007614"(short-term memory)|go:"GO:0007616"(long-term memory)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010021"(amylopectin biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031550"(positive regulation of brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044381"(glucose import in response to insulin stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046323"(glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0098694"(regulation of synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0098793"(presynapse)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002441("Glucose transporter, type 4 (GLUT4)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-189200|ensembl:ENSRNOG00000017226(gene)|ensembl:ENSRNOT00000023256(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)	rgd:620366|refseq:NP_001032362.1|refseq:NP_001032363.1|refseq:NP_001032364.1|refseq:NP_071792.1|refseq:XP_008761484.1|refseq:XP_017448358.1|refseq:XP_017448359.1|refseq:XP_017448360.1|refseq:XP_017448361.1|refseq:XP_017448362.1|refseq:XP_017448363.1|refseq:XP_017448364.1|ensembl:ENSRNOG00000014562(gene)|ensembl:ENSRNOT00000019529(transcript)|ensembl:ENSRNOT00000083843(transcript)|ensembl:ENSRNOT00000091765(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0003727"(single-stranded RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006397"(mRNA processing)|go:"GO:0008380"(RNA splicing)|go:"GO:0017025"(TBP-class protein binding)|go:"GO:0043484"(regulation of RNA splicing)|go:"GO:0071013"(catalytic step 2 spliceosome)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR012996(Zinc finger, CHHC-type)|interpro:IPR035979|mint:Q794E4|reactome:R-RNO-6803529|reactome:R-RNO-72163	-	-	-	caution:"The participant EBI-349571(P68370) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919386(Q7TP47) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920972(Q5XIP9) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-916419(P11980) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919578(Q8R491) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920554(Q5U3Z7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920647(Q5U2X8) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920585(Q7TP24) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-779677(P05426) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-915744(P02454) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|agonist:Insulin was shown to increase or decrease GLUT4 protein interactions in specific cases.|comment:"Insulin decreased GLUT4 interactions with the following proteins: Q9ER30 (Sarcosin), P09527 (Rab-7), O88960 (N-ethylmaleimide sensitive), P09456 (PKA I regulatory subunit), P27881 (Hexokinase type II), P07872 (Acyl-coenzyme A oxidase), Q6DGF1 (Isocitrate dehydrogenase), Q9EQX9 (Ubiquitin-conjugating), Q63446 (Polyubiquitin), P24268 (Cathepsin D), Q91XW0 (Heat shock protein 86), Q5FVH0 (unknown), P58405 (Striatin 3), Q62667 (Major vault protein), Q66H50 (unknown), Q09167 (splicing factor), Q9JHU5 (Arfaptin 1)."|comment:"Insulin increased GLUT4 interaction with the following proteins:Q9Z1P2 (R-actinin-1), P45592 (Cofilin), Q9QXQ0 (R-actinin-4), P26473 (ADP-ribosylation factor), P26437 (ADP-ribosylation factor),   Q7TNP1 (Basigin 2), Q6P6R2 (Dihydrolipoamide dehydrogenase),   P04797 (GAPDH), Q63081 (Protein disulfide isomerase), P29457 (47 kDa heat shock protein), Q9R1J8 (Leprecan), O88638 (Putative eps protein),   Q64375 (Synaptonemal complex)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:NDPK - Interactions involving proteins containing InterPro domain IPR001564, Nucleoside diphosphate kinase, core.	taxid:10116(rat-l6)|taxid:10116(Rattus norvegicus)	-	2006/02/15	2021/11/30	rogid:PbFY2lfrty8yw40Jq7ShR7xfuV410116	rogid:Ntkz1kjm7RteL6dBzMmC0sipvCk10116	intact-crc:44F3A2176D02515F|rigid:9RVm0UBcqQF4k06RGKO89Bg16Q8	false	myc tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P19357	uniprotkb:Q792I0	intact:EBI-915426|uniprotkb:P97900|ensembl:ENSRNOP00000023256	intact:EBI-704626|ensembl:ENSRNOP00000065941	psi-mi:glut4_rat(display_long)|uniprotkb:Glucose transporter type 4, insulin-responsive(gene name synonym)|uniprotkb:Slc2a4(gene name)|psi-mi:Slc2a4(display_short)|uniprotkb:Glut4(gene name synonym)	psi-mi:lin7c_rat(display_long)|uniprotkb:Mammalian lin-seven protein 3(gene name synonym)|uniprotkb:Vertebrate lin-7 homolog 3(gene name synonym)|uniprotkb:Lin7c(gene name)|psi-mi:Lin7c(display_short)|uniprotkb:Mals3(gene name synonym)|uniprotkb:Veli3(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Foster et al. (2006)	pubmed:16396496|mint:MINT-5218203	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-921030	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2711|refseq:NP_036883.1|refseq:XP_006246658.1|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007611"(learning or memory)|go:"GO:0007614"(short-term memory)|go:"GO:0007616"(long-term memory)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010021"(amylopectin biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031550"(positive regulation of brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044381"(glucose import in response to insulin stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046323"(glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0098694"(regulation of synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0098793"(presynapse)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002441("Glucose transporter, type 4 (GLUT4)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-189200|ensembl:ENSRNOG00000017226(gene)|ensembl:ENSRNOT00000023256(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)	rgd:621164|refseq:NP_068623.1|ensembl:ENSRNOG00000045698(gene)|ensembl:ENSRNOT00000073258(transcript)|go:"GO:0002011"(morphogenesis of an epithelial sheet)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0006887"(exocytosis)|go:"GO:0007269"(neurotransmitter secretion)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0015031"(protein transport)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0045199"(maintenance of epithelial cell apical/basal polarity)|go:"GO:0045202"(synapse)|go:"GO:0097016"(L27 domain binding)|go:"GO:0097025"(MPP7-DLG1-LIN7 complex)|go:"GO:0098793"(presynapse)|go:"GO:0098839"(postsynaptic density membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1903361"(protein localization to basolateral plasma membrane)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR004172(L27)|interpro:IPR014775(L27, C-terminal)|interpro:IPR017365(Lin-7 homologue)|interpro:IPR036034|interpro:IPR036892|reactome:R-RNO-212676	-	-	-	caution:"The participant EBI-349571(P68370) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919386(Q7TP47) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920972(Q5XIP9) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-916419(P11980) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919578(Q8R491) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920554(Q5U3Z7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920647(Q5U2X8) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920585(Q7TP24) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-779677(P05426) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-915744(P02454) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|agonist:Insulin was shown to increase or decrease GLUT4 protein interactions in specific cases.|comment:"Insulin decreased GLUT4 interactions with the following proteins: Q9ER30 (Sarcosin), P09527 (Rab-7), O88960 (N-ethylmaleimide sensitive), P09456 (PKA I regulatory subunit), P27881 (Hexokinase type II), P07872 (Acyl-coenzyme A oxidase), Q6DGF1 (Isocitrate dehydrogenase), Q9EQX9 (Ubiquitin-conjugating), Q63446 (Polyubiquitin), P24268 (Cathepsin D), Q91XW0 (Heat shock protein 86), Q5FVH0 (unknown), P58405 (Striatin 3), Q62667 (Major vault protein), Q66H50 (unknown), Q09167 (splicing factor), Q9JHU5 (Arfaptin 1)."|comment:"Insulin increased GLUT4 interaction with the following proteins:Q9Z1P2 (R-actinin-1), P45592 (Cofilin), Q9QXQ0 (R-actinin-4), P26473 (ADP-ribosylation factor), P26437 (ADP-ribosylation factor),   Q7TNP1 (Basigin 2), Q6P6R2 (Dihydrolipoamide dehydrogenase),   P04797 (GAPDH), Q63081 (Protein disulfide isomerase), P29457 (47 kDa heat shock protein), Q9R1J8 (Leprecan), O88638 (Putative eps protein),   Q64375 (Synaptonemal complex)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:NDPK - Interactions involving proteins containing InterPro domain IPR001564, Nucleoside diphosphate kinase, core.	taxid:10116(rat-l6)|taxid:10116(Rattus norvegicus)	-	2006/02/15	2021/11/30	rogid:PbFY2lfrty8yw40Jq7ShR7xfuV410116	rogid:F2rasaJ64Olc9qScN79LJRqsUEE10116	intact-crc:44F3A2176D02515F|rigid:9RVm0UBcqQF4k06RGKO89Bg16Q8	false	myc tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P19357	uniprotkb:Q75NI5	intact:EBI-915426|uniprotkb:P97900|ensembl:ENSRNOP00000023256	intact:EBI-919295|uniprotkb:F1LQ16|ensembl:ENSRNOP00000034685	psi-mi:glut4_rat(display_long)|uniprotkb:Glucose transporter type 4, insulin-responsive(gene name synonym)|uniprotkb:Slc2a4(gene name)|psi-mi:Slc2a4(display_short)|uniprotkb:Glut4(gene name synonym)	psi-mi:q75ni5_rat(display_long)|uniprotkb:rCG_51596(orf name)|uniprotkb:Cdh15(gene name)|psi-mi:Cdh15(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Foster et al. (2006)	pubmed:16396496|mint:MINT-5218203	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-921030	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2711|refseq:NP_036883.1|refseq:XP_006246658.1|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007611"(learning or memory)|go:"GO:0007614"(short-term memory)|go:"GO:0007616"(long-term memory)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010021"(amylopectin biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031550"(positive regulation of brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044381"(glucose import in response to insulin stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046323"(glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0098694"(regulation of synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0098793"(presynapse)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002441("Glucose transporter, type 4 (GLUT4)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-189200|ensembl:ENSRNOG00000017226(gene)|ensembl:ENSRNOT00000023256(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)	rgd:1303000|refseq:NP_997496.1|ensembl:ENSRNOG00000027954(gene)|ensembl:ENSRNOT00000033352(transcript)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005901"(caveola)|go:"GO:0007156"(homophilic cell adhesion via plasma membrane adhesion molecules)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016342"(catenin complex)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0045296"(cadherin binding)|go:"GO:0098742"(cell-cell adhesion via plasma-membrane adhesion molecules)|interpro:IPR000233(Cadherin cytoplasmic region)|interpro:IPR002126(Cadherin)|interpro:IPR015919(Cadherin-like)|interpro:IPR020894|interpro:IPR027397|interpro:IPR039808|reactome:R-RNO-418990|reactome:R-RNO-525793	-	-	-	caution:"The participant EBI-349571(P68370) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919386(Q7TP47) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920972(Q5XIP9) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-916419(P11980) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919578(Q8R491) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920554(Q5U3Z7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920647(Q5U2X8) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920585(Q7TP24) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-779677(P05426) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-915744(P02454) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|agonist:Insulin was shown to increase or decrease GLUT4 protein interactions in specific cases.|comment:"Insulin decreased GLUT4 interactions with the following proteins: Q9ER30 (Sarcosin), P09527 (Rab-7), O88960 (N-ethylmaleimide sensitive), P09456 (PKA I regulatory subunit), P27881 (Hexokinase type II), P07872 (Acyl-coenzyme A oxidase), Q6DGF1 (Isocitrate dehydrogenase), Q9EQX9 (Ubiquitin-conjugating), Q63446 (Polyubiquitin), P24268 (Cathepsin D), Q91XW0 (Heat shock protein 86), Q5FVH0 (unknown), P58405 (Striatin 3), Q62667 (Major vault protein), Q66H50 (unknown), Q09167 (splicing factor), Q9JHU5 (Arfaptin 1)."|comment:"Insulin increased GLUT4 interaction with the following proteins:Q9Z1P2 (R-actinin-1), P45592 (Cofilin), Q9QXQ0 (R-actinin-4), P26473 (ADP-ribosylation factor), P26437 (ADP-ribosylation factor),   Q7TNP1 (Basigin 2), Q6P6R2 (Dihydrolipoamide dehydrogenase),   P04797 (GAPDH), Q63081 (Protein disulfide isomerase), P29457 (47 kDa heat shock protein), Q9R1J8 (Leprecan), O88638 (Putative eps protein),   Q64375 (Synaptonemal complex)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:NDPK - Interactions involving proteins containing InterPro domain IPR001564, Nucleoside diphosphate kinase, core.	taxid:10116(rat-l6)|taxid:10116(Rattus norvegicus)	-	2006/02/15	2021/11/30	rogid:PbFY2lfrty8yw40Jq7ShR7xfuV410116	rogid:oX2O8fThj/GvYtRzWiZE7GhGiHo10116	intact-crc:44F3A2176D02515F|rigid:9RVm0UBcqQF4k06RGKO89Bg16Q8	false	myc tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P19357	uniprotkb:P05982	intact:EBI-915426|uniprotkb:P97900|ensembl:ENSRNOP00000023256	intact:EBI-915944|ensembl:ENSRNOP00000017175|uniprotkb:Q63478	psi-mi:glut4_rat(display_long)|uniprotkb:Glucose transporter type 4, insulin-responsive(gene name synonym)|uniprotkb:Slc2a4(gene name)|psi-mi:Slc2a4(display_short)|uniprotkb:Glut4(gene name synonym)	psi-mi:nqo1_rat(display_long)|uniprotkb:Nqo1(gene name)|psi-mi:Nqo1(display_short)|uniprotkb:Nmor1(gene name synonym)|uniprotkb:Quinone reductase 1(gene name synonym)|uniprotkb:"NAD(P)H:quinone oxidoreductase 1"(gene name synonym)|uniprotkb:DT-diaphorase(gene name synonym)|uniprotkb:Azoreductase(gene name synonym)|uniprotkb:Phylloquinone reductase(gene name synonym)|uniprotkb:Menadione reductase(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Foster et al. (2006)	pubmed:16396496|mint:MINT-5218203	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-921030	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2711|refseq:NP_036883.1|refseq:XP_006246658.1|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007611"(learning or memory)|go:"GO:0007614"(short-term memory)|go:"GO:0007616"(long-term memory)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010021"(amylopectin biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031550"(positive regulation of brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044381"(glucose import in response to insulin stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046323"(glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0098694"(regulation of synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0098793"(presynapse)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002441("Glucose transporter, type 4 (GLUT4)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-189200|ensembl:ENSRNOG00000017226(gene)|ensembl:ENSRNOT00000023256(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)	go:"GO:0030425"(dendrite)|go:"GO:0032355"(response to estradiol)|go:"GO:0033574"(response to testosterone)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043086"(negative regulation of catalytic activity)|go:"GO:0043279"(response to alkaloid)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045454"(cell redox homeostasis)|go:"GO:0045471"(response to ethanol)|go:"GO:0050136"("NADH dehydrogenase (quinone) activity")|go:"GO:0051602"(response to electrical stimulus)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0070995"(NADPH oxidation)|go:"GO:0071248"(cellular response to metal ion)|go:"GO:1901698"(response to nitrogen compound)|go:"GO:1904772"(response to tetrachloromethane)|go:"GO:1904844"(response to L-glutamine)|go:"GO:1904880"(response to hydrogen sulfide)|go:"GO:1905395"(response to flavonoid)|ensembl:ENSRNOG00000012772(gene)|ensembl:ENSRNOT00000017174(transcript)|go:"GO:0002931"(response to ischemia)|go:"GO:0003955"("NAD(P)H dehydrogenase (quinone) activity")|go:"GO:0004784"(superoxide dismutase activity)|go:"GO:0014070"(response to organic cyclic compound)|go:"GO:0005737"(cytoplasm)|go:"GO:0014075"(response to amine)|go:"GO:0005829"(cytosol)|go:"GO:0006116"(NADH oxidation)|go:"GO:0006801"(superoxide metabolic process)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008753"("NADPH dehydrogenase (quinone) activity")|go:"GO:0009410"(response to xenobiotic stimulus)|go:"GO:0009725"(response to hormone)|go:"GO:0009743"(response to carbohydrate)|go:"GO:0010033"(response to organic substance)|rgd:2503|refseq:NP_058696.2|interpro:IPR003680(Flavodoxin-like fold)|interpro:IPR029039|rcsb pdb:1QRD|reactome:R-RNO-350562	-	-	-	caution:"The participant EBI-349571(P68370) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919386(Q7TP47) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920972(Q5XIP9) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-916419(P11980) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919578(Q8R491) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920554(Q5U3Z7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920647(Q5U2X8) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920585(Q7TP24) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-779677(P05426) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-915744(P02454) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|agonist:Insulin was shown to increase or decrease GLUT4 protein interactions in specific cases.|comment:"Insulin decreased GLUT4 interactions with the following proteins: Q9ER30 (Sarcosin), P09527 (Rab-7), O88960 (N-ethylmaleimide sensitive), P09456 (PKA I regulatory subunit), P27881 (Hexokinase type II), P07872 (Acyl-coenzyme A oxidase), Q6DGF1 (Isocitrate dehydrogenase), Q9EQX9 (Ubiquitin-conjugating), Q63446 (Polyubiquitin), P24268 (Cathepsin D), Q91XW0 (Heat shock protein 86), Q5FVH0 (unknown), P58405 (Striatin 3), Q62667 (Major vault protein), Q66H50 (unknown), Q09167 (splicing factor), Q9JHU5 (Arfaptin 1)."|comment:"Insulin increased GLUT4 interaction with the following proteins:Q9Z1P2 (R-actinin-1), P45592 (Cofilin), Q9QXQ0 (R-actinin-4), P26473 (ADP-ribosylation factor), P26437 (ADP-ribosylation factor),   Q7TNP1 (Basigin 2), Q6P6R2 (Dihydrolipoamide dehydrogenase),   P04797 (GAPDH), Q63081 (Protein disulfide isomerase), P29457 (47 kDa heat shock protein), Q9R1J8 (Leprecan), O88638 (Putative eps protein),   Q64375 (Synaptonemal complex)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:NDPK - Interactions involving proteins containing InterPro domain IPR001564, Nucleoside diphosphate kinase, core.	taxid:10116(rat-l6)|taxid:10116(Rattus norvegicus)	-	2006/02/15	2021/11/30	rogid:PbFY2lfrty8yw40Jq7ShR7xfuV410116	rogid:8/ynxZp6aPapTZ2lXQLnv4MuuLk10116	intact-crc:44F3A2176D02515F|rigid:9RVm0UBcqQF4k06RGKO89Bg16Q8	false	myc tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P19357	uniprotkb:P05765	intact:EBI-915426|uniprotkb:P97900|ensembl:ENSRNOP00000023256	intact:EBI-915936	psi-mi:glut4_rat(display_long)|uniprotkb:Glucose transporter type 4, insulin-responsive(gene name synonym)|uniprotkb:Slc2a4(gene name)|psi-mi:Slc2a4(display_short)|uniprotkb:Glut4(gene name synonym)	psi-mi:rs21_rat(display_long)|uniprotkb:Rps21(gene name)|psi-mi:Rps21(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Foster et al. (2006)	pubmed:16396496|mint:MINT-5218203	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-921030	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2711|refseq:NP_036883.1|refseq:XP_006246658.1|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007611"(learning or memory)|go:"GO:0007614"(short-term memory)|go:"GO:0007616"(long-term memory)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010021"(amylopectin biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031550"(positive regulation of brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044381"(glucose import in response to insulin stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046323"(glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0098694"(regulation of synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0098793"(presynapse)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002441("Glucose transporter, type 4 (GLUT4)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-189200|ensembl:ENSRNOG00000017226(gene)|ensembl:ENSRNOT00000023256(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)	go:"GO:0000447"("endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)")|go:"GO:0000461"("endonucleolytic cleavage to generate mature 3'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)")|go:"GO:0002181"(cytoplasmic translation)|go:"GO:0003735"(structural constituent of ribosome)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0022627"(cytosolic small ribosomal subunit)|go:"GO:0042788"(polysomal ribosome)|go:"GO:0043022"(ribosome binding)|reactome:R-RNO-156827|reactome:R-RNO-1799339|reactome:R-RNO-6791226|reactome:R-RNO-72649|reactome:R-RNO-72689|reactome:R-RNO-72695|reactome:R-RNO-72702|reactome:R-RNO-72706|reactome:R-RNO-975956|reactome:R-RNO-975957|rgd:621038|refseq:NP_112373.1|interpro:IPR001931(Ribosomal protein S21e)|interpro:IPR018279|mint:P05765|interpro:IPR038579	-	-	-	caution:"The participant EBI-349571(P68370) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919386(Q7TP47) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920972(Q5XIP9) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-916419(P11980) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919578(Q8R491) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920554(Q5U3Z7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920647(Q5U2X8) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920585(Q7TP24) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-779677(P05426) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-915744(P02454) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|agonist:Insulin was shown to increase or decrease GLUT4 protein interactions in specific cases.|comment:"Insulin decreased GLUT4 interactions with the following proteins: Q9ER30 (Sarcosin), P09527 (Rab-7), O88960 (N-ethylmaleimide sensitive), P09456 (PKA I regulatory subunit), P27881 (Hexokinase type II), P07872 (Acyl-coenzyme A oxidase), Q6DGF1 (Isocitrate dehydrogenase), Q9EQX9 (Ubiquitin-conjugating), Q63446 (Polyubiquitin), P24268 (Cathepsin D), Q91XW0 (Heat shock protein 86), Q5FVH0 (unknown), P58405 (Striatin 3), Q62667 (Major vault protein), Q66H50 (unknown), Q09167 (splicing factor), Q9JHU5 (Arfaptin 1)."|comment:"Insulin increased GLUT4 interaction with the following proteins:Q9Z1P2 (R-actinin-1), P45592 (Cofilin), Q9QXQ0 (R-actinin-4), P26473 (ADP-ribosylation factor), P26437 (ADP-ribosylation factor),   Q7TNP1 (Basigin 2), Q6P6R2 (Dihydrolipoamide dehydrogenase),   P04797 (GAPDH), Q63081 (Protein disulfide isomerase), P29457 (47 kDa heat shock protein), Q9R1J8 (Leprecan), O88638 (Putative eps protein),   Q64375 (Synaptonemal complex)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:NDPK - Interactions involving proteins containing InterPro domain IPR001564, Nucleoside diphosphate kinase, core.	taxid:10116(rat-l6)|taxid:10116(Rattus norvegicus)	-	2006/02/15	2021/11/30	rogid:PbFY2lfrty8yw40Jq7ShR7xfuV410116	rogid:HrwegqCYbBe/ARDZo7T+6/Z054Y10116	intact-crc:44F3A2176D02515F|rigid:9RVm0UBcqQF4k06RGKO89Bg16Q8	false	myc tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P19357	uniprotkb:P05712	intact:EBI-915426|uniprotkb:P97900|ensembl:ENSRNOP00000023256	intact:EBI-915929	psi-mi:glut4_rat(display_long)|uniprotkb:Glucose transporter type 4, insulin-responsive(gene name synonym)|uniprotkb:Slc2a4(gene name)|psi-mi:Slc2a4(display_short)|uniprotkb:Glut4(gene name synonym)	psi-mi:rab2a_rat(display_long)|uniprotkb:Rab2a(gene name)|psi-mi:Rab2a(display_short)|uniprotkb:Rab2(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Foster et al. (2006)	pubmed:16396496|mint:MINT-5218203	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-921030	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2711|refseq:NP_036883.1|refseq:XP_006246658.1|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007611"(learning or memory)|go:"GO:0007614"(short-term memory)|go:"GO:0007616"(long-term memory)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010021"(amylopectin biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031550"(positive regulation of brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044381"(glucose import in response to insulin stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046323"(glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0098694"(regulation of synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0098793"(presynapse)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002441("Glucose transporter, type 4 (GLUT4)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-189200|ensembl:ENSRNOG00000017226(gene)|ensembl:ENSRNOT00000023256(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)	go:"GO:0000139"(Golgi membrane)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0007030"(Golgi organization)|go:"GO:0015031"(protein transport)|go:"GO:0016020"(membrane)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0019003"(GDP binding)|go:"GO:0032482"(Rab protein signal transduction)|go:"GO:0033116"(endoplasmic reticulum-Golgi intermediate compartment membrane)|go:"GO:0042470"(melanosome)|go:"GO:0043025"(neuronal cell body)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0098993"(anchored component of synaptic vesicle membrane)|reactome:R-RNO-162658|reactome:R-RNO-8873719|rgd:68323|refseq:NP_113906.1|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR001806(Ras GTPase)|interpro:IPR027417|mint:P05712	-	-	-	caution:"The participant EBI-349571(P68370) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919386(Q7TP47) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920972(Q5XIP9) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-916419(P11980) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919578(Q8R491) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920554(Q5U3Z7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920647(Q5U2X8) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920585(Q7TP24) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-779677(P05426) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-915744(P02454) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|agonist:Insulin was shown to increase or decrease GLUT4 protein interactions in specific cases.|comment:"Insulin decreased GLUT4 interactions with the following proteins: Q9ER30 (Sarcosin), P09527 (Rab-7), O88960 (N-ethylmaleimide sensitive), P09456 (PKA I regulatory subunit), P27881 (Hexokinase type II), P07872 (Acyl-coenzyme A oxidase), Q6DGF1 (Isocitrate dehydrogenase), Q9EQX9 (Ubiquitin-conjugating), Q63446 (Polyubiquitin), P24268 (Cathepsin D), Q91XW0 (Heat shock protein 86), Q5FVH0 (unknown), P58405 (Striatin 3), Q62667 (Major vault protein), Q66H50 (unknown), Q09167 (splicing factor), Q9JHU5 (Arfaptin 1)."|comment:"Insulin increased GLUT4 interaction with the following proteins:Q9Z1P2 (R-actinin-1), P45592 (Cofilin), Q9QXQ0 (R-actinin-4), P26473 (ADP-ribosylation factor), P26437 (ADP-ribosylation factor),   Q7TNP1 (Basigin 2), Q6P6R2 (Dihydrolipoamide dehydrogenase),   P04797 (GAPDH), Q63081 (Protein disulfide isomerase), P29457 (47 kDa heat shock protein), Q9R1J8 (Leprecan), O88638 (Putative eps protein),   Q64375 (Synaptonemal complex)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:NDPK - Interactions involving proteins containing InterPro domain IPR001564, Nucleoside diphosphate kinase, core.	taxid:10116(rat-l6)|taxid:10116(Rattus norvegicus)	-	2006/02/15	2021/11/30	rogid:PbFY2lfrty8yw40Jq7ShR7xfuV410116	rogid:Tgp/mFQYzl3y51w6GcV+6dAeks010116	intact-crc:44F3A2176D02515F|rigid:9RVm0UBcqQF4k06RGKO89Bg16Q8	false	myc tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P19357	uniprotkb:P69897	intact:EBI-915426|uniprotkb:P97900|ensembl:ENSRNOP00000023256	intact:EBI-350912|uniprotkb:P05218|uniprotkb:Q6P9X8|uniprotkb:Q9CY33|uniprotkb:Q8WUC1|ensembl:ENSRNOP00000075269	psi-mi:glut4_rat(display_long)|uniprotkb:Glucose transporter type 4, insulin-responsive(gene name synonym)|uniprotkb:Slc2a4(gene name)|psi-mi:Slc2a4(display_short)|uniprotkb:Glut4(gene name synonym)	psi-mi:tbb5_rat(display_long)|uniprotkb:Tubb5(gene name)|psi-mi:Tubb5(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Foster et al. (2006)	pubmed:16396496|mint:MINT-5218203	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-921030	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2711|refseq:NP_036883.1|refseq:XP_006246658.1|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007611"(learning or memory)|go:"GO:0007614"(short-term memory)|go:"GO:0007616"(long-term memory)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010021"(amylopectin biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031550"(positive regulation of brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044381"(glucose import in response to insulin stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046323"(glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0098694"(regulation of synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0098793"(presynapse)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002441("Glucose transporter, type 4 (GLUT4)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-189200|ensembl:ENSRNOG00000017226(gene)|ensembl:ENSRNOT00000023256(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)	rgd:628596|refseq:NP_775125.1|go:"GO:0005634"(nucleus)|go:"GO:0005641"(nuclear envelope lumen)|go:"GO:0005737"(cytoplasm)|go:"GO:0005874"(microtubule)|go:"GO:0007017"(microtubule-based process)|go:"GO:0009987"(cellular process)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032794"(GTPase activating protein binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042288"(MHC class I protein binding)|go:"GO:0044297"(cell body)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045121"(membrane raft)|go:"GO:0050807"(regulation of synapse organization)|go:"GO:0051225"(spindle assembly)|interpro:IPR000217(Tubulin)|interpro:IPR002453(Beta tubulin)|go:"GO:0005525"(GTP binding)|interpro:IPR003008(Tubulin/FtsZ, GTPase)|interpro:IPR008280(Tubulin/FtsZ, C-terminal)|interpro:IPR013838(Beta tubulin, autoregulation binding site)|interpro:IPR017975|interpro:IPR018316|interpro:IPR023123|interpro:IPR036525|interpro:IPR037103|mint:P69897|reactome:R-RNO-2565942|reactome:R-RNO-380259|reactome:R-RNO-380270|reactome:R-RNO-380284|reactome:R-RNO-380320|reactome:R-RNO-5620912|reactome:R-RNO-6798695|reactome:R-RNO-8854518|ensembl:ENSRNOG00000061216(gene)|ensembl:ENSRNOT00000079854(transcript)|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0005200"(structural constituent of cytoskeleton)	-	-	-	caution:"The participant EBI-349571(P68370) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919386(Q7TP47) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920972(Q5XIP9) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-916419(P11980) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919578(Q8R491) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920554(Q5U3Z7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920647(Q5U2X8) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920585(Q7TP24) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-779677(P05426) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-915744(P02454) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|agonist:Insulin was shown to increase or decrease GLUT4 protein interactions in specific cases.|comment:"Insulin decreased GLUT4 interactions with the following proteins: Q9ER30 (Sarcosin), P09527 (Rab-7), O88960 (N-ethylmaleimide sensitive), P09456 (PKA I regulatory subunit), P27881 (Hexokinase type II), P07872 (Acyl-coenzyme A oxidase), Q6DGF1 (Isocitrate dehydrogenase), Q9EQX9 (Ubiquitin-conjugating), Q63446 (Polyubiquitin), P24268 (Cathepsin D), Q91XW0 (Heat shock protein 86), Q5FVH0 (unknown), P58405 (Striatin 3), Q62667 (Major vault protein), Q66H50 (unknown), Q09167 (splicing factor), Q9JHU5 (Arfaptin 1)."|comment:"Insulin increased GLUT4 interaction with the following proteins:Q9Z1P2 (R-actinin-1), P45592 (Cofilin), Q9QXQ0 (R-actinin-4), P26473 (ADP-ribosylation factor), P26437 (ADP-ribosylation factor),   Q7TNP1 (Basigin 2), Q6P6R2 (Dihydrolipoamide dehydrogenase),   P04797 (GAPDH), Q63081 (Protein disulfide isomerase), P29457 (47 kDa heat shock protein), Q9R1J8 (Leprecan), O88638 (Putative eps protein),   Q64375 (Synaptonemal complex)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:NDPK - Interactions involving proteins containing InterPro domain IPR001564, Nucleoside diphosphate kinase, core.	taxid:10116(rat-l6)|taxid:10116(Rattus norvegicus)	-	2006/02/15	2021/11/30	rogid:PbFY2lfrty8yw40Jq7ShR7xfuV410116	rogid:B6pmb1dvCroZXGd/1Zazi+s72GA10116	intact-crc:44F3A2176D02515F|rigid:9RVm0UBcqQF4k06RGKO89Bg16Q8	false	myc tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P19357	uniprotkb:P68182	intact:EBI-915426|uniprotkb:P97900|ensembl:ENSRNOP00000023256	intact:EBI-400695|uniprotkb:P05206|ensembl:ENSRNOP00000062228	psi-mi:glut4_rat(display_long)|uniprotkb:Glucose transporter type 4, insulin-responsive(gene name synonym)|uniprotkb:Slc2a4(gene name)|psi-mi:Slc2a4(display_short)|uniprotkb:Glut4(gene name synonym)	psi-mi:kapcb_rat(display_long)|uniprotkb:Prkacb(gene name)|psi-mi:Prkacb(display_short)|uniprotkb:Pkacb(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Foster et al. (2006)	pubmed:16396496|mint:MINT-5218203	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-921030	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2711|refseq:NP_036883.1|refseq:XP_006246658.1|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007611"(learning or memory)|go:"GO:0007614"(short-term memory)|go:"GO:0007616"(long-term memory)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010021"(amylopectin biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031550"(positive regulation of brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044381"(glucose import in response to insulin stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046323"(glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0098694"(regulation of synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0098793"(presynapse)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002441("Glucose transporter, type 4 (GLUT4)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-189200|ensembl:ENSRNOG00000017226(gene)|ensembl:ENSRNOT00000023256(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)	rgd:1310574|refseq:NP_001071113.1|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005952"(cAMP-dependent protein kinase complex)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0010737"(protein kinase A signaling)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0034237"(protein kinase A regulatory subunit binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051447"(negative regulation of meiotic cell cycle)|go:"GO:0070613"(regulation of protein processing)|go:"GO:0097338"(response to clozapine)|go:"GO:0097546"(ciliary base)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1901621"(negative regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning)|interpro:IPR000719(Protein kinase, core)|ensembl:ENSRNOG00000004978(gene)|ensembl:ENSRNOT00000068739(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0001843"(neural tube closure)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004679"(AMP-activated protein kinase activity)|go:"GO:0004691"(cAMP-dependent protein kinase activity)|go:"GO:0005524"(ATP binding)|interpro:IPR000961(Protein kinase, C-terminal)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR044109|reactome:R-RNO-163615|reactome:R-RNO-164378|reactome:R-RNO-180024|reactome:R-RNO-381676|reactome:R-RNO-392517|reactome:R-RNO-422356|reactome:R-RNO-432040|reactome:R-RNO-4420097|reactome:R-RNO-442720|reactome:R-RNO-5610785|reactome:R-RNO-5610787|reactome:R-RNO-5687128|reactome:R-RNO-8853659|reactome:R-RNO-8963896|reactome:R-RNO-983231	-	-	-	caution:"The participant EBI-349571(P68370) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919386(Q7TP47) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920972(Q5XIP9) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-916419(P11980) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919578(Q8R491) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920554(Q5U3Z7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920647(Q5U2X8) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920585(Q7TP24) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-779677(P05426) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-915744(P02454) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|agonist:Insulin was shown to increase or decrease GLUT4 protein interactions in specific cases.|comment:"Insulin decreased GLUT4 interactions with the following proteins: Q9ER30 (Sarcosin), P09527 (Rab-7), O88960 (N-ethylmaleimide sensitive), P09456 (PKA I regulatory subunit), P27881 (Hexokinase type II), P07872 (Acyl-coenzyme A oxidase), Q6DGF1 (Isocitrate dehydrogenase), Q9EQX9 (Ubiquitin-conjugating), Q63446 (Polyubiquitin), P24268 (Cathepsin D), Q91XW0 (Heat shock protein 86), Q5FVH0 (unknown), P58405 (Striatin 3), Q62667 (Major vault protein), Q66H50 (unknown), Q09167 (splicing factor), Q9JHU5 (Arfaptin 1)."|comment:"Insulin increased GLUT4 interaction with the following proteins:Q9Z1P2 (R-actinin-1), P45592 (Cofilin), Q9QXQ0 (R-actinin-4), P26473 (ADP-ribosylation factor), P26437 (ADP-ribosylation factor),   Q7TNP1 (Basigin 2), Q6P6R2 (Dihydrolipoamide dehydrogenase),   P04797 (GAPDH), Q63081 (Protein disulfide isomerase), P29457 (47 kDa heat shock protein), Q9R1J8 (Leprecan), O88638 (Putative eps protein),   Q64375 (Synaptonemal complex)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:NDPK - Interactions involving proteins containing InterPro domain IPR001564, Nucleoside diphosphate kinase, core.	taxid:10116(rat-l6)|taxid:10116(Rattus norvegicus)	-	2006/02/15	2021/11/30	rogid:PbFY2lfrty8yw40Jq7ShR7xfuV410116	rogid:9278c8xZsjU90+vryXpzUc0y/G010116	intact-crc:44F3A2176D02515F|rigid:9RVm0UBcqQF4k06RGKO89Bg16Q8	false	myc tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P19357	uniprotkb:P68101	intact:EBI-915426|uniprotkb:P97900|ensembl:ENSRNOP00000023256	intact:EBI-915919|uniprotkb:P05199|ensembl:ENSRNOP00000013375	psi-mi:glut4_rat(display_long)|uniprotkb:Glucose transporter type 4, insulin-responsive(gene name synonym)|uniprotkb:Slc2a4(gene name)|psi-mi:Slc2a4(display_short)|uniprotkb:Glut4(gene name synonym)	psi-mi:if2a_rat(display_long)|uniprotkb:Eif2s1(gene name)|psi-mi:Eif2s1(display_short)|uniprotkb:Eif2a(gene name synonym)|uniprotkb:Eukaryotic translation initiation factor 2 subunit alpha(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Foster et al. (2006)	pubmed:16396496|mint:MINT-5218203	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-921030	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2711|refseq:NP_036883.1|refseq:XP_006246658.1|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007611"(learning or memory)|go:"GO:0007614"(short-term memory)|go:"GO:0007616"(long-term memory)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010021"(amylopectin biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031550"(positive regulation of brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044381"(glucose import in response to insulin stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046323"(glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0098694"(regulation of synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0098793"(presynapse)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002441("Glucose transporter, type 4 (GLUT4)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-189200|ensembl:ENSRNOG00000017226(gene)|ensembl:ENSRNOT00000023256(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)	rgd:620963|refseq:NP_062229.1|ensembl:ENSRNOG00000009432(gene)|ensembl:ENSRNOT00000013375(transcript)|go:"GO:0003743"(translation initiation factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005850"(eukaryotic translation initiation factor 2 complex)|go:"GO:0005851"(eukaryotic translation initiation factor 2B complex)|go:"GO:0006412"(translation)|go:"GO:0007568"(aging)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0032057"(negative regulation of translational initiation in response to stress)|go:"GO:0033290"(eukaryotic 48S preinitiation complex)|go:"GO:0034063"(stress granule assembly)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0034605"(cellular response to heat)|go:"GO:0034644"(cellular response to UV)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0036499"(PERK-mediated unfolded protein response)|go:"GO:0043022"(ribosome binding)|go:"GO:0043558"(regulation of translational initiation in response to stress)|go:"GO:0043614"(multi-eIF complex)|go:"GO:0044207"(translation initiation ternary complex)|go:"GO:0045202"(synapse)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0097451"(glial limiting end-foot)|go:"GO:1901216"(positive regulation of neuron death)|go:"GO:1905098"(negative regulation of guanyl-nucleotide exchange factor activity)|go:"GO:1990737"(response to manganese-induced endoplasmic reticulum stress)|go:"GO:2000676"(positive regulation of type B pancreatic cell apoptotic process)|interpro:IPR003029(S1, RNA binding)|interpro:IPR011488(Eukaryotic translation initiation factor 2, alpha subunit)|interpro:IPR012340(Nucleic acid-binding, OB-fold)|interpro:IPR022967|interpro:IPR024054|interpro:IPR024055|interpro:IPR044126|reactome:R-RNO-156827|reactome:R-RNO-381042|reactome:R-RNO-382556|reactome:R-RNO-72649|reactome:R-RNO-72695|reactome:R-RNO-72702|reactome:R-RNO-72706|reactome:R-RNO-72731	-	-	-	caution:"The participant EBI-349571(P68370) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919386(Q7TP47) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920972(Q5XIP9) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-916419(P11980) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919578(Q8R491) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920554(Q5U3Z7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920647(Q5U2X8) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920585(Q7TP24) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-779677(P05426) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-915744(P02454) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|agonist:Insulin was shown to increase or decrease GLUT4 protein interactions in specific cases.|comment:"Insulin decreased GLUT4 interactions with the following proteins: Q9ER30 (Sarcosin), P09527 (Rab-7), O88960 (N-ethylmaleimide sensitive), P09456 (PKA I regulatory subunit), P27881 (Hexokinase type II), P07872 (Acyl-coenzyme A oxidase), Q6DGF1 (Isocitrate dehydrogenase), Q9EQX9 (Ubiquitin-conjugating), Q63446 (Polyubiquitin), P24268 (Cathepsin D), Q91XW0 (Heat shock protein 86), Q5FVH0 (unknown), P58405 (Striatin 3), Q62667 (Major vault protein), Q66H50 (unknown), Q09167 (splicing factor), Q9JHU5 (Arfaptin 1)."|comment:"Insulin increased GLUT4 interaction with the following proteins:Q9Z1P2 (R-actinin-1), P45592 (Cofilin), Q9QXQ0 (R-actinin-4), P26473 (ADP-ribosylation factor), P26437 (ADP-ribosylation factor),   Q7TNP1 (Basigin 2), Q6P6R2 (Dihydrolipoamide dehydrogenase),   P04797 (GAPDH), Q63081 (Protein disulfide isomerase), P29457 (47 kDa heat shock protein), Q9R1J8 (Leprecan), O88638 (Putative eps protein),   Q64375 (Synaptonemal complex)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:NDPK - Interactions involving proteins containing InterPro domain IPR001564, Nucleoside diphosphate kinase, core.	taxid:10116(rat-l6)|taxid:10116(Rattus norvegicus)	-	2006/02/15	2021/11/30	rogid:PbFY2lfrty8yw40Jq7ShR7xfuV410116	rogid:FKeyVi3QK42ZWZl8m/PyPoleIDQ10116	intact-crc:44F3A2176D02515F|rigid:9RVm0UBcqQF4k06RGKO89Bg16Q8	false	myc tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P19357	uniprotkb:P05197	intact:EBI-915426|uniprotkb:P97900|ensembl:ENSRNOP00000023256	intact:EBI-915895|uniprotkb:P97619|ensembl:ENSRNOP00000041821	psi-mi:glut4_rat(display_long)|uniprotkb:Glucose transporter type 4, insulin-responsive(gene name synonym)|uniprotkb:Slc2a4(gene name)|psi-mi:Slc2a4(display_short)|uniprotkb:Glut4(gene name synonym)	psi-mi:ef2_rat(display_long)|uniprotkb:Eef2(gene name)|psi-mi:Eef2(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Foster et al. (2006)	pubmed:16396496|mint:MINT-5218203	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-921030	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2711|refseq:NP_036883.1|refseq:XP_006246658.1|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007611"(learning or memory)|go:"GO:0007614"(short-term memory)|go:"GO:0007616"(long-term memory)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010021"(amylopectin biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031550"(positive regulation of brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044381"(glucose import in response to insulin stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046323"(glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0098694"(regulation of synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0098793"(presynapse)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002441("Glucose transporter, type 4 (GLUT4)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-189200|ensembl:ENSRNOG00000017226(gene)|ensembl:ENSRNOT00000023256(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)	rgd:61979|refseq:NP_058941.1|ensembl:ENSRNOG00000020266(gene)|ensembl:ENSRNOT00000047450(transcript)|go:"GO:0002039"(p53 binding)|go:"GO:0002244"(hematopoietic progenitor cell differentiation)|go:"GO:0002931"(response to ischemia)|go:"GO:0003009"(skeletal muscle contraction)|go:"GO:0003723"(RNA binding)|go:"GO:0003746"(translation elongation factor activity)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0005886"(plasma membrane)|go:"GO:0006414"(translational elongation)|go:"GO:0007568"(aging)|go:"GO:0008097"(5S rRNA binding)|go:"GO:0014009"(glial cell proliferation)|go:"GO:0016235"(aggresome)|go:"GO:0019901"(protein kinase binding)|go:"GO:0032355"(response to estradiol)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0035914"(skeletal muscle cell differentiation)|go:"GO:0042493"|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0042788"(polysomal ribosome)|go:"GO:0043022"(ribosome binding)|go:"GO:0045121"(membrane raft)|go:"GO:0045202"(synapse)|go:"GO:0045471"(response to ethanol)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0051015"(actin filament binding)|go:"GO:0051593"(response to folic acid)|go:"GO:1990416"(cellular response to brain-derived neurotrophic factor stimulus)|go:"GO:1990904"(ribonucleoprotein complex)|go:"GO:2000767"(positive regulation of cytoplasmic translation)|interpro:IPR000640(Translation elongation factor EFG/EF2, C-terminal)|interpro:IPR000795(Protein synthesis factor, GTP-binding)|interpro:IPR004161(Translation elongation factor EFTu/EF1A, domain 2)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR005517(Translation elongation factor EFG/EF2, domain IV)|interpro:IPR009000(Translation elongation and initiation factors/Ribosomal, beta-barrel)|interpro:IPR014721(Ribosomal protein S5 domain 2-type fold)|interpro:IPR020568|interpro:IPR027417|interpro:IPR031157|interpro:IPR035647|interpro:IPR041095|mint:P05197|reactome:R-RNO-156902|reactome:R-RNO-5358493|reactome:R-RNO-6798695	-	-	-	caution:"The participant EBI-349571(P68370) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919386(Q7TP47) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920972(Q5XIP9) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-916419(P11980) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919578(Q8R491) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920554(Q5U3Z7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920647(Q5U2X8) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920585(Q7TP24) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-779677(P05426) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-915744(P02454) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|agonist:Insulin was shown to increase or decrease GLUT4 protein interactions in specific cases.|comment:"Insulin decreased GLUT4 interactions with the following proteins: Q9ER30 (Sarcosin), P09527 (Rab-7), O88960 (N-ethylmaleimide sensitive), P09456 (PKA I regulatory subunit), P27881 (Hexokinase type II), P07872 (Acyl-coenzyme A oxidase), Q6DGF1 (Isocitrate dehydrogenase), Q9EQX9 (Ubiquitin-conjugating), Q63446 (Polyubiquitin), P24268 (Cathepsin D), Q91XW0 (Heat shock protein 86), Q5FVH0 (unknown), P58405 (Striatin 3), Q62667 (Major vault protein), Q66H50 (unknown), Q09167 (splicing factor), Q9JHU5 (Arfaptin 1)."|comment:"Insulin increased GLUT4 interaction with the following proteins:Q9Z1P2 (R-actinin-1), P45592 (Cofilin), Q9QXQ0 (R-actinin-4), P26473 (ADP-ribosylation factor), P26437 (ADP-ribosylation factor),   Q7TNP1 (Basigin 2), Q6P6R2 (Dihydrolipoamide dehydrogenase),   P04797 (GAPDH), Q63081 (Protein disulfide isomerase), P29457 (47 kDa heat shock protein), Q9R1J8 (Leprecan), O88638 (Putative eps protein),   Q64375 (Synaptonemal complex)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:NDPK - Interactions involving proteins containing InterPro domain IPR001564, Nucleoside diphosphate kinase, core.	taxid:10116(rat-l6)|taxid:10116(Rattus norvegicus)	-	2006/02/15	2021/11/30	rogid:PbFY2lfrty8yw40Jq7ShR7xfuV410116	rogid:JpTfRnV5VR9V+mR+c5hxYJ0FsM410116	intact-crc:44F3A2176D02515F|rigid:9RVm0UBcqQF4k06RGKO89Bg16Q8	false	myc tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P19357	uniprotkb:P05065	intact:EBI-915426|uniprotkb:P97900|ensembl:ENSRNOP00000023256	intact:EBI-522118|uniprotkb:Q63038|ensembl:ENSRNOP00000068764|ensembl:ENSRNOP00000069507|ensembl:ENSRNOP00000069540	psi-mi:glut4_rat(display_long)|uniprotkb:Glucose transporter type 4, insulin-responsive(gene name synonym)|uniprotkb:Slc2a4(gene name)|psi-mi:Slc2a4(display_short)|uniprotkb:Glut4(gene name synonym)	psi-mi:aldoa_rat(display_long)|uniprotkb:Muscle-type aldolase(gene name synonym)|uniprotkb:Aldoa(gene name)|psi-mi:Aldoa(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Foster et al. (2006)	pubmed:16396496|mint:MINT-5218203	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-921030	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2711|refseq:NP_036883.1|refseq:XP_006246658.1|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007611"(learning or memory)|go:"GO:0007614"(short-term memory)|go:"GO:0007616"(long-term memory)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010021"(amylopectin biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031550"(positive regulation of brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044381"(glucose import in response to insulin stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046323"(glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0098694"(regulation of synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0098793"(presynapse)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002441("Glucose transporter, type 4 (GLUT4)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-189200|ensembl:ENSRNOG00000017226(gene)|ensembl:ENSRNOT00000023256(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)	rgd:2089|refseq:NP_001170776.1|refseq:NP_036627.1|ensembl:ENSRNOG00000052802(gene)|ensembl:ENSRNOT00000080988(transcript)|ensembl:ENSRNOT00000087928(transcript)|ensembl:ENSRNOT00000088473(transcript)|go:"GO:0000792"(heterochromatin)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002020"(protease binding)|go:"GO:0004332"(fructose-bisphosphate aldolase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006096"(glycolytic process)|go:"GO:0009408"(response to heat)|go:"GO:0016020"(membrane)|go:"GO:0019242"(methylglyoxal biosynthetic process)|go:"GO:0030018"(Z disc)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030388"(fructose 1,6-bisphosphate metabolic process)|go:"GO:0031430"(M band)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035094"(response to nicotine)|go:"GO:0035686"(sperm fibrous sheath)|go:"GO:0043627"(response to estrogen)|go:"GO:0051289"(protein homotetramerization)|interpro:IPR000741(Fructose-bisphosphate aldolase, class-I)|interpro:IPR013785(Aldolase-type TIM barrel)|interpro:IPR029768|mint:P05065|reactome:R-RNO-114608|reactome:R-RNO-6798695|reactome:R-RNO-70171|reactome:R-RNO-70263|refseq:XP_006230273.1|refseq:NP_001258465.1	-	-	-	caution:"The participant EBI-349571(P68370) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919386(Q7TP47) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920972(Q5XIP9) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-916419(P11980) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919578(Q8R491) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920554(Q5U3Z7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920647(Q5U2X8) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920585(Q7TP24) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-779677(P05426) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-915744(P02454) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|agonist:Insulin was shown to increase or decrease GLUT4 protein interactions in specific cases.|comment:"Insulin decreased GLUT4 interactions with the following proteins: Q9ER30 (Sarcosin), P09527 (Rab-7), O88960 (N-ethylmaleimide sensitive), P09456 (PKA I regulatory subunit), P27881 (Hexokinase type II), P07872 (Acyl-coenzyme A oxidase), Q6DGF1 (Isocitrate dehydrogenase), Q9EQX9 (Ubiquitin-conjugating), Q63446 (Polyubiquitin), P24268 (Cathepsin D), Q91XW0 (Heat shock protein 86), Q5FVH0 (unknown), P58405 (Striatin 3), Q62667 (Major vault protein), Q66H50 (unknown), Q09167 (splicing factor), Q9JHU5 (Arfaptin 1)."|comment:"Insulin increased GLUT4 interaction with the following proteins:Q9Z1P2 (R-actinin-1), P45592 (Cofilin), Q9QXQ0 (R-actinin-4), P26473 (ADP-ribosylation factor), P26437 (ADP-ribosylation factor),   Q7TNP1 (Basigin 2), Q6P6R2 (Dihydrolipoamide dehydrogenase),   P04797 (GAPDH), Q63081 (Protein disulfide isomerase), P29457 (47 kDa heat shock protein), Q9R1J8 (Leprecan), O88638 (Putative eps protein),   Q64375 (Synaptonemal complex)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:NDPK - Interactions involving proteins containing InterPro domain IPR001564, Nucleoside diphosphate kinase, core.	taxid:10116(rat-l6)|taxid:10116(Rattus norvegicus)	-	2006/02/15	2021/11/30	rogid:PbFY2lfrty8yw40Jq7ShR7xfuV410116	rogid:dUcYtyffbl8dC/1SD/ZtEtiFyB010116	intact-crc:44F3A2176D02515F|rigid:9RVm0UBcqQF4k06RGKO89Bg16Q8	false	myc tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P19357	uniprotkb:P04906	intact:EBI-915426|uniprotkb:P97900|ensembl:ENSRNOP00000023256	intact:EBI-915884|ensembl:ENSRNOP00000024601	psi-mi:glut4_rat(display_long)|uniprotkb:Glucose transporter type 4, insulin-responsive(gene name synonym)|uniprotkb:Slc2a4(gene name)|psi-mi:Slc2a4(display_short)|uniprotkb:Glut4(gene name synonym)	psi-mi:gstp1_rat(display_long)|uniprotkb:GST 7-7(gene name synonym)|uniprotkb:Chain 7(gene name synonym)|uniprotkb:GST class-pi(gene name synonym)|uniprotkb:Gstp1(gene name)|psi-mi:Gstp1(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Foster et al. (2006)	pubmed:16396496|mint:MINT-5218203	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-921030	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2711|refseq:NP_036883.1|refseq:XP_006246658.1|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007611"(learning or memory)|go:"GO:0007614"(short-term memory)|go:"GO:0007616"(long-term memory)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010021"(amylopectin biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031550"(positive regulation of brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044381"(glucose import in response to insulin stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046323"(glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0098694"(regulation of synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0098793"(presynapse)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002441("Glucose transporter, type 4 (GLUT4)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-189200|ensembl:ENSRNOG00000017226(gene)|ensembl:ENSRNOT00000023256(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)	rgd:2758|refseq:NP_036709.1|ensembl:ENSRNOG00000018237(gene)|ensembl:ENSRNOT00000024601(transcript)|go:"GO:0000302"(response to reactive oxygen species)|go:"GO:0004364"(glutathione transferase activity)|go:"GO:0004602"(glutathione peroxidase activity)|go:"GO:0005504"(fatty acid binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0006693"(prostaglandin metabolic process)|go:"GO:0006749"(glutathione metabolic process)|go:"GO:0006805"(xenobiotic metabolic process)|go:"GO:0008432"(JUN kinase binding)|go:"GO:0009636"(response to toxic substance)|go:"GO:0009890"(negative regulation of biosynthetic process)|go:"GO:0014003"(oligodendrocyte development)|go:"GO:0019207"(kinase regulator activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0031100"(animal organ regeneration)|go:"GO:0031667"(response to nutrient levels)|go:"GO:0032355"(response to estradiol)|go:"GO:0032691"(negative regulation of interleukin-1 beta production)|go:"GO:0032720"(negative regulation of tumor necrosis factor production)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0032872"(regulation of stress-activated MAPK cascade)|go:"GO:0032873"(negative regulation of stress-activated MAPK cascade)|go:"GO:0032930"(positive regulation of superoxide anion generation)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033591"(response to L-ascorbic acid)|go:"GO:0035726"(common myeloid progenitor cell proliferation)|go:"GO:0035730"(S-nitrosoglutathione binding)|go:"GO:0035731"(dinitrosyl-iron complex binding)|go:"GO:0043124"(negative regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043200"(response to amino acid)|go:"GO:0043407"(negative regulation of MAP kinase activity)|go:"GO:0043508"(negative regulation of JUN kinase activity)|go:"GO:0043651"(linoleic acid metabolic process)|go:"GO:0045471"(response to ethanol)|go:"GO:0048147"(negative regulation of fibroblast proliferation)|go:"GO:0051122"(hepoxilin biosynthetic process)|go:"GO:0051771"(negative regulation of nitric-oxide synthase biosynthetic process)|go:"GO:0070372"(regulation of ERK1 and ERK2 cascade)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0070664"(negative regulation of leukocyte proliferation)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|go:"GO:0071385"(cellular response to glucocorticoid stimulus)|go:"GO:0071460"(cellular response to cell-matrix adhesion)|go:"GO:0071638"(negative regulation of monocyte chemotactic protein-1 production)|go:"GO:0071672"(negative regulation of smooth muscle cell chemotaxis)|go:"GO:0097057"(TRAF2-GSTP1 complex)|go:"GO:1901687"(glutathione derivative biosynthetic process)|go:"GO:1904706"(negative regulation of vascular associated smooth muscle cell proliferation)|go:"GO:2000469"(negative regulation of peroxidase activity)|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway)|interpro:IPR003082(Glutathione S-transferase, Pi class)|interpro:IPR004045(Glutathione S-transferase, N-terminal)|interpro:IPR004046(Glutathione S-transferase, C-terminal)|interpro:IPR010987(Glutathione S-transferase, C-terminal-like)|interpro:IPR036249|interpro:IPR036282|reactome:R-RNO-156590|reactome:R-RNO-3299685|reactome:R-RNO-6798695	-	-	-	caution:"The participant EBI-349571(P68370) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919386(Q7TP47) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920972(Q5XIP9) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-916419(P11980) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919578(Q8R491) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920554(Q5U3Z7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920647(Q5U2X8) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920585(Q7TP24) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-779677(P05426) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-915744(P02454) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|agonist:Insulin was shown to increase or decrease GLUT4 protein interactions in specific cases.|comment:"Insulin decreased GLUT4 interactions with the following proteins: Q9ER30 (Sarcosin), P09527 (Rab-7), O88960 (N-ethylmaleimide sensitive), P09456 (PKA I regulatory subunit), P27881 (Hexokinase type II), P07872 (Acyl-coenzyme A oxidase), Q6DGF1 (Isocitrate dehydrogenase), Q9EQX9 (Ubiquitin-conjugating), Q63446 (Polyubiquitin), P24268 (Cathepsin D), Q91XW0 (Heat shock protein 86), Q5FVH0 (unknown), P58405 (Striatin 3), Q62667 (Major vault protein), Q66H50 (unknown), Q09167 (splicing factor), Q9JHU5 (Arfaptin 1)."|comment:"Insulin increased GLUT4 interaction with the following proteins:Q9Z1P2 (R-actinin-1), P45592 (Cofilin), Q9QXQ0 (R-actinin-4), P26473 (ADP-ribosylation factor), P26437 (ADP-ribosylation factor),   Q7TNP1 (Basigin 2), Q6P6R2 (Dihydrolipoamide dehydrogenase),   P04797 (GAPDH), Q63081 (Protein disulfide isomerase), P29457 (47 kDa heat shock protein), Q9R1J8 (Leprecan), O88638 (Putative eps protein),   Q64375 (Synaptonemal complex)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:NDPK - Interactions involving proteins containing InterPro domain IPR001564, Nucleoside diphosphate kinase, core.	taxid:10116(rat-l6)|taxid:10116(Rattus norvegicus)	-	2006/02/15	2021/11/30	rogid:PbFY2lfrty8yw40Jq7ShR7xfuV410116	rogid:XrpFVbOiaqINUJ8VwyYrJUpIx4I10116	intact-crc:44F3A2176D02515F|rigid:9RVm0UBcqQF4k06RGKO89Bg16Q8	false	myc tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P19357	uniprotkb:P04897	intact:EBI-915426|uniprotkb:P97900|ensembl:ENSRNOP00000023256	intact:EBI-915875|ensembl:ENSRNOP00000022550	psi-mi:glut4_rat(display_long)|uniprotkb:Glucose transporter type 4, insulin-responsive(gene name synonym)|uniprotkb:Slc2a4(gene name)|psi-mi:Slc2a4(display_short)|uniprotkb:Glut4(gene name synonym)	psi-mi:gnai2_rat(display_long)|uniprotkb:Adenylate cyclase-inhibiting G alpha protein(gene name synonym)|uniprotkb:Gnai2(gene name)|psi-mi:Gnai2(display_short)|uniprotkb:Gnai-2(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Foster et al. (2006)	pubmed:16396496|mint:MINT-5218203	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-921030	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2711|refseq:NP_036883.1|refseq:XP_006246658.1|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007611"(learning or memory)|go:"GO:0007614"(short-term memory)|go:"GO:0007616"(long-term memory)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010021"(amylopectin biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031550"(positive regulation of brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044381"(glucose import in response to insulin stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046323"(glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0098694"(regulation of synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0098793"(presynapse)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002441("Glucose transporter, type 4 (GLUT4)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-189200|ensembl:ENSRNOG00000017226(gene)|ensembl:ENSRNOT00000023256(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)	rgd:620243|refseq:NP_112297.1|refseq:XP_006243920.1|dip:DIP-607N|ensembl:ENSRNOG00000016592(gene)|ensembl:ENSRNOT00000022550(transcript)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0001973"(G protein-coupled adenosine receptor signaling pathway)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005834"(heterotrimeric G-protein complex)|go:"GO:0005886"(plasma membrane)|go:"GO:0007049"(cell cycle)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007188"(adenylate cyclase-modulating G protein-coupled receptor signaling pathway)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0007193"(adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway)|go:"GO:0007213"(G protein-coupled acetylcholine receptor signaling pathway)|go:"GO:0007214"(gamma-aminobutyric acid signaling pathway)|go:"GO:0008283"(cell population proliferation)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030425"(dendrite)|go:"GO:0030496"(midbody)|go:"GO:0031683"(G-protein beta/gamma-subunit complex binding)|go:"GO:0032930"(positive regulation of superoxide anion generation)|go:"GO:0033864"("positive regulation of NAD(P)H oxidase activity")|go:"GO:0035810"(positive regulation of urine volume)|go:"GO:0035815"(positive regulation of renal sodium excretion)|go:"GO:0044297"(cell body)|go:"GO:0045121"(membrane raft)|go:"GO:0045202"(synapse)|go:"GO:0045955"(negative regulation of calcium ion-dependent exocytosis)|go:"GO:0046628"(positive regulation of insulin receptor signaling pathway)|go:"GO:0046872"(metal ion binding)|go:"GO:0050805"(negative regulation of synaptic transmission)|go:"GO:0051301"(cell division)|go:"GO:0051924"(regulation of calcium ion transport)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0140199"(negative regulation of adenylate cyclase-activating adrenergic receptor signaling pathway involved in heart process)|go:"GO:1903614"(negative regulation of protein tyrosine phosphatase activity)|go:"GO:1904707"(positive regulation of vascular associated smooth muscle cell proliferation)|go:"GO:2000179"(positive regulation of neural precursor cell proliferation)|go:"GO:2001234"(negative regulation of apoptotic signaling pathway)|interpro:IPR001019("Guanine nucleotide binding protein (G-protein), alpha subunit")|interpro:IPR001408(G-protein alpha subunit, group I)|interpro:IPR011025(G protein alpha subunit, helical insertion)|interpro:IPR027417|mint:P04897|reactome:R-RNO-170670|reactome:R-RNO-392170|reactome:R-RNO-400042|reactome:R-RNO-418594|reactome:R-RNO-9009391	-	-	-	caution:"The participant EBI-349571(P68370) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919386(Q7TP47) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920972(Q5XIP9) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-916419(P11980) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919578(Q8R491) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920554(Q5U3Z7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920647(Q5U2X8) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920585(Q7TP24) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-779677(P05426) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-915744(P02454) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|agonist:Insulin was shown to increase or decrease GLUT4 protein interactions in specific cases.|comment:"Insulin decreased GLUT4 interactions with the following proteins: Q9ER30 (Sarcosin), P09527 (Rab-7), O88960 (N-ethylmaleimide sensitive), P09456 (PKA I regulatory subunit), P27881 (Hexokinase type II), P07872 (Acyl-coenzyme A oxidase), Q6DGF1 (Isocitrate dehydrogenase), Q9EQX9 (Ubiquitin-conjugating), Q63446 (Polyubiquitin), P24268 (Cathepsin D), Q91XW0 (Heat shock protein 86), Q5FVH0 (unknown), P58405 (Striatin 3), Q62667 (Major vault protein), Q66H50 (unknown), Q09167 (splicing factor), Q9JHU5 (Arfaptin 1)."|comment:"Insulin increased GLUT4 interaction with the following proteins:Q9Z1P2 (R-actinin-1), P45592 (Cofilin), Q9QXQ0 (R-actinin-4), P26473 (ADP-ribosylation factor), P26437 (ADP-ribosylation factor),   Q7TNP1 (Basigin 2), Q6P6R2 (Dihydrolipoamide dehydrogenase),   P04797 (GAPDH), Q63081 (Protein disulfide isomerase), P29457 (47 kDa heat shock protein), Q9R1J8 (Leprecan), O88638 (Putative eps protein),   Q64375 (Synaptonemal complex)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:NDPK - Interactions involving proteins containing InterPro domain IPR001564, Nucleoside diphosphate kinase, core.	taxid:10116(rat-l6)|taxid:10116(Rattus norvegicus)	-	2006/02/15	2021/11/30	rogid:PbFY2lfrty8yw40Jq7ShR7xfuV410116	rogid:TXAwhCxZGiWn/waR1XaK92nByh410116	intact-crc:44F3A2176D02515F|rigid:9RVm0UBcqQF4k06RGKO89Bg16Q8	false	myc tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P19357	uniprotkb:P63095	intact:EBI-915426|uniprotkb:P97900|ensembl:ENSRNOP00000023256	intact:EBI-444717|uniprotkb:P04894|uniprotkb:P08755|uniprotkb:Q05087|uniprotkb:Q45QM7|uniprotkb:Q9Z1R8	psi-mi:glut4_rat(display_long)|uniprotkb:Glucose transporter type 4, insulin-responsive(gene name synonym)|uniprotkb:Slc2a4(gene name)|psi-mi:Slc2a4(display_short)|uniprotkb:Glut4(gene name synonym)	psi-mi:gnas2_rat(display_long)|uniprotkb:Adenylate cyclase-stimulating G alpha protein(gene name synonym)|uniprotkb:G-alpha-8(gene name synonym)|uniprotkb:Gnas(gene name)|psi-mi:Gnas(display_short)|uniprotkb:Gnas1(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Foster et al. (2006)	pubmed:16396496|mint:MINT-5218203	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-921030	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2711|refseq:NP_036883.1|refseq:XP_006246658.1|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007611"(learning or memory)|go:"GO:0007614"(short-term memory)|go:"GO:0007616"(long-term memory)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010021"(amylopectin biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031550"(positive regulation of brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044381"(glucose import in response to insulin stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046323"(glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0098694"(regulation of synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0098793"(presynapse)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002441("Glucose transporter, type 4 (GLUT4)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-189200|ensembl:ENSRNOG00000017226(gene)|ensembl:ENSRNOT00000023256(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)	rgd:2716|refseq:NP_062005.1|interpro:IPR000367(G-protein alpha subunit, group S)|interpro:IPR001019("Guanine nucleotide binding protein (G-protein), alpha subunit")|interpro:IPR011025(G protein alpha subunit, helical insertion)|go:"GO:0001501"(skeletal system development)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0001726"(ruffle)|go:"GO:0001894"(tissue homeostasis)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0001958"(endochondral ossification)|go:"GO:0001965"(G-protein alpha-subunit binding)|go:"GO:0003924"(GTPase activity)|go:"GO:0005159"(insulin-like growth factor receptor binding)|go:"GO:0005525"(GTP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005834"(heterotrimeric G-protein complex)|go:"GO:0005886"(plasma membrane)|go:"GO:0006112"(energy reserve metabolic process)|go:"GO:0006306"(DNA methylation)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0071380"(cellular response to prostaglandin E stimulus)|go:"GO:0071514"(genomic imprinting)|go:"GO:0071870"(cellular response to catecholamine stimulus)|go:"GO:0071880"(adenylate cyclase-activating adrenergic receptor signaling pathway)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:2000828"(regulation of parathyroid hormone secretion)|go:"GO:0007188"(adenylate cyclase-modulating G protein-coupled receptor signaling pathway)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0007191"(adenylate cyclase-activating dopamine receptor signaling pathway)|go:"GO:0007606"(sensory perception of chemical stimulus)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009791"(post-embryonic development)|go:"GO:0010765"(positive regulation of sodium ion transport)|go:"GO:0010856"(adenylate cyclase activator activity)|go:"GO:0016020"(membrane)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030142"(COPI-coated Golgi to ER transport vesicle)|go:"GO:0030425"(dendrite)|go:"GO:0031681"(G-protein beta-subunit binding)|go:"GO:0031683"(G-protein beta/gamma-subunit complex binding)|go:"GO:0031698"(beta-2 adrenergic receptor binding)|go:"GO:0031748"(D1 dopamine receptor binding)|go:"GO:0031852"(mu-type opioid receptor binding)|go:"GO:0035116"(embryonic hindlimb morphogenesis)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0035814"(negative regulation of renal sodium excretion)|go:"GO:0040015"(negative regulation of multicellular organism growth)|go:"GO:0040032"(post-embryonic body morphogenesis)|go:"GO:0042493"|go:"GO:0043014"(alpha-tubulin binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0043588"(skin development)|go:"GO:0043950"(positive regulation of cAMP-mediated signaling)|go:"GO:0045121"(membrane raft)|go:"GO:0045669"(positive regulation of osteoblast differentiation)|go:"GO:0045672"(positive regulation of osteoclast differentiation)|go:"GO:0045776"(negative regulation of blood pressure)|go:"GO:0046872"(metal ion binding)|go:"GO:0047391"(alkylglycerophosphoethanolamine phosphodiesterase activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048589"(developmental growth)|go:"GO:0048701"(embryonic cranial skeleton morphogenesis)|go:"GO:0051216"(cartilage development)|go:"GO:0051430"(corticotropin-releasing hormone receptor 1 binding)|go:"GO:0055037"(recycling endosome)|go:"GO:0055074"(calcium ion homeostasis)|go:"GO:0060348"(bone development)|go:"GO:0070527"(platelet aggregation)|interpro:IPR027417|mint:P63095	-	-	-	caution:"The participant EBI-349571(P68370) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919386(Q7TP47) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920972(Q5XIP9) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-916419(P11980) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919578(Q8R491) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920554(Q5U3Z7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920647(Q5U2X8) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920585(Q7TP24) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-779677(P05426) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-915744(P02454) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|agonist:Insulin was shown to increase or decrease GLUT4 protein interactions in specific cases.|comment:"Insulin decreased GLUT4 interactions with the following proteins: Q9ER30 (Sarcosin), P09527 (Rab-7), O88960 (N-ethylmaleimide sensitive), P09456 (PKA I regulatory subunit), P27881 (Hexokinase type II), P07872 (Acyl-coenzyme A oxidase), Q6DGF1 (Isocitrate dehydrogenase), Q9EQX9 (Ubiquitin-conjugating), Q63446 (Polyubiquitin), P24268 (Cathepsin D), Q91XW0 (Heat shock protein 86), Q5FVH0 (unknown), P58405 (Striatin 3), Q62667 (Major vault protein), Q66H50 (unknown), Q09167 (splicing factor), Q9JHU5 (Arfaptin 1)."|comment:"Insulin increased GLUT4 interaction with the following proteins:Q9Z1P2 (R-actinin-1), P45592 (Cofilin), Q9QXQ0 (R-actinin-4), P26473 (ADP-ribosylation factor), P26437 (ADP-ribosylation factor),   Q7TNP1 (Basigin 2), Q6P6R2 (Dihydrolipoamide dehydrogenase),   P04797 (GAPDH), Q63081 (Protein disulfide isomerase), P29457 (47 kDa heat shock protein), Q9R1J8 (Leprecan), O88638 (Putative eps protein),   Q64375 (Synaptonemal complex)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:NDPK - Interactions involving proteins containing InterPro domain IPR001564, Nucleoside diphosphate kinase, core.	taxid:10116(rat-l6)|taxid:10116(Rattus norvegicus)	-	2006/02/15	2021/11/30	rogid:PbFY2lfrty8yw40Jq7ShR7xfuV410116	rogid:1yRRwUpxAu++bhy6TZHaOWy3Tdw10116	intact-crc:44F3A2176D02515F|rigid:9RVm0UBcqQF4k06RGKO89Bg16Q8	false	myc tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P19357	uniprotkb:P04797	intact:EBI-915426|uniprotkb:P97900|ensembl:ENSRNOP00000023256	intact:EBI-349219|uniprotkb:P09328|ensembl:ENSRNOP00000040878|uniprotkb:Q5M916|uniprotkb:Q9QWU4|intact:EBI-6096024	psi-mi:glut4_rat(display_long)|uniprotkb:Glucose transporter type 4, insulin-responsive(gene name synonym)|uniprotkb:Slc2a4(gene name)|psi-mi:Slc2a4(display_short)|uniprotkb:Glut4(gene name synonym)	psi-mi:g3p_rat(display_long)|uniprotkb:Gapdh(gene name)|psi-mi:Gapdh(display_short)|uniprotkb:38 kDa BFA-dependent ADP-ribosylation substrate(gene name synonym)|uniprotkb:BARS-38(gene name synonym)|uniprotkb:Gapd(gene name synonym)|uniprotkb:Peptidyl-cysteine S-nitrosylase GAPDH(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Foster et al. (2006)	pubmed:16396496|mint:MINT-5218203	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-921030	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2711|refseq:NP_036883.1|refseq:XP_006246658.1|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007611"(learning or memory)|go:"GO:0007614"(short-term memory)|go:"GO:0007616"(long-term memory)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010021"(amylopectin biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031550"(positive regulation of brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044381"(glucose import in response to insulin stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046323"(glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0098694"(regulation of synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0098793"(presynapse)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002441("Glucose transporter, type 4 (GLUT4)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-189200|ensembl:ENSRNOG00000017226(gene)|ensembl:ENSRNOT00000023256(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)	rgd:2661|refseq:NP_058704.1|ensembl:ENSRNOG00000018630(gene)|ensembl:ENSRNOT00000050443(transcript)|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0001819"(positive regulation of cytokine production)|go:"GO:0004365"("glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity")|interpro:IPR020831|interpro:IPR036291|mint:P04797|reactome:R-RNO-70171|reactome:R-RNO-70263|go:"GO:0005737"(cytoplasm)|go:"GO:0005811"(lipid droplet)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005975"(carbohydrate metabolic process)|go:"GO:0006094"(gluconeogenesis)|go:"GO:0006096"(glycolytic process)|go:"GO:0006915"(apoptotic process)|go:"GO:0007565"(female pregnancy)|go:"GO:0008017"(microtubule binding)|go:"GO:0010951"(negative regulation of endopeptidase activity)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0019828"(aspartic-type endopeptidase inhibitor activity)|go:"GO:0019899"(enzyme binding)|go:"GO:0019933"(cAMP-mediated signaling)|go:"GO:0031640"(killing of cells of another organism)|go:"GO:0005634"(nucleus)|go:"GO:0032481"(positive regulation of type I interferon production)|go:"GO:0050821"(protein stabilization)|go:"GO:0050832"(defense response to fungus)|go:"GO:0051287"(NAD binding)|go:"GO:0035605"(peptidyl-cysteine S-nitrosylase activity)|go:"GO:0051402"(neuron apoptotic process)|go:"GO:0051873"(killing by host of symbiont cells)|go:"GO:0035606"(peptidyl-cysteine S-trans-nitrosylation)|go:"GO:0060359"(response to ammonium ion)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0042802"(identical protein binding)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0097452"(GAIT complex)|go:"GO:0097718"(disordered domain specific binding)|go:"GO:0050661"(NADP binding)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|go:"GO:1905460"(negative regulation of vascular associated smooth muscle cell apoptotic process)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR006424(Glyceraldehyde-3-phosphate dehydrogenase, type I)|interpro:IPR020828|interpro:IPR020829|interpro:IPR020830|refseq:XP_017447924.1|refseq:XP_017458425.1	-	-	-	caution:"The participant EBI-349571(P68370) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919386(Q7TP47) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920972(Q5XIP9) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-916419(P11980) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919578(Q8R491) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920554(Q5U3Z7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920647(Q5U2X8) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920585(Q7TP24) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-779677(P05426) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-915744(P02454) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|agonist:Insulin was shown to increase or decrease GLUT4 protein interactions in specific cases.|comment:"Insulin decreased GLUT4 interactions with the following proteins: Q9ER30 (Sarcosin), P09527 (Rab-7), O88960 (N-ethylmaleimide sensitive), P09456 (PKA I regulatory subunit), P27881 (Hexokinase type II), P07872 (Acyl-coenzyme A oxidase), Q6DGF1 (Isocitrate dehydrogenase), Q9EQX9 (Ubiquitin-conjugating), Q63446 (Polyubiquitin), P24268 (Cathepsin D), Q91XW0 (Heat shock protein 86), Q5FVH0 (unknown), P58405 (Striatin 3), Q62667 (Major vault protein), Q66H50 (unknown), Q09167 (splicing factor), Q9JHU5 (Arfaptin 1)."|comment:"Insulin increased GLUT4 interaction with the following proteins:Q9Z1P2 (R-actinin-1), P45592 (Cofilin), Q9QXQ0 (R-actinin-4), P26473 (ADP-ribosylation factor), P26437 (ADP-ribosylation factor),   Q7TNP1 (Basigin 2), Q6P6R2 (Dihydrolipoamide dehydrogenase),   P04797 (GAPDH), Q63081 (Protein disulfide isomerase), P29457 (47 kDa heat shock protein), Q9R1J8 (Leprecan), O88638 (Putative eps protein),   Q64375 (Synaptonemal complex)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:NDPK - Interactions involving proteins containing InterPro domain IPR001564, Nucleoside diphosphate kinase, core.	taxid:10116(rat-l6)|taxid:10116(Rattus norvegicus)	-	2006/02/15	2021/11/30	rogid:PbFY2lfrty8yw40Jq7ShR7xfuV410116	rogid:4TDODEC0WVLzUSY2w1fVSmP9C5010116	intact-crc:44F3A2176D02515F|rigid:9RVm0UBcqQF4k06RGKO89Bg16Q8	false	myc tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P19357	uniprotkb:P04785	intact:EBI-915426|uniprotkb:P97900|ensembl:ENSRNOP00000023256	intact:EBI-915861|uniprotkb:P13700|ensembl:ENSRNOP00000051841	psi-mi:glut4_rat(display_long)|uniprotkb:Glucose transporter type 4, insulin-responsive(gene name synonym)|uniprotkb:Slc2a4(gene name)|psi-mi:Slc2a4(display_short)|uniprotkb:Glut4(gene name synonym)	psi-mi:pdia1_rat(display_long)|uniprotkb:Prolyl 4-hydroxylase subunit beta(gene name synonym)|uniprotkb:Cellular thyroid hormone-binding protein(gene name synonym)|uniprotkb:P4hb(gene name)|psi-mi:P4hb(display_short)|uniprotkb:Pdia1(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Foster et al. (2006)	pubmed:16396496|mint:MINT-5218203	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-921030	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2711|refseq:NP_036883.1|refseq:XP_006246658.1|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007611"(learning or memory)|go:"GO:0007614"(short-term memory)|go:"GO:0007616"(long-term memory)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010021"(amylopectin biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031550"(positive regulation of brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044381"(glucose import in response to insulin stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046323"(glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0098694"(regulation of synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0098793"(presynapse)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002441("Glucose transporter, type 4 (GLUT4)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-189200|ensembl:ENSRNOG00000017226(gene)|ensembl:ENSRNOT00000023256(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)	refseq:NP_037130.2|rgd:3244|ensembl:ENSRNOG00000036689(gene)|ensembl:ENSRNOT00000054958(transcript)|go:"GO:0003756"(protein disulfide isomerase activity)|go:"GO:0003779"(actin binding)|go:"GO:0004656"(procollagen-proline 4-dioxygenase activity)|go:"GO:0005178"(integrin binding)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005793"(endoplasmic reticulum-Golgi intermediate compartment)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006457"(protein folding)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0015035"(protein-disulfide reductase activity)|go:"GO:0016222"(procollagen-proline 4-dioxygenase complex)|go:"GO:0016972"(thiol oxidase activity)|go:"GO:0018401"(peptidyl-proline hydroxylation to 4-hydroxy-L-proline)|go:"GO:0019899"(enzyme binding)|go:"GO:0030027"(lamellipodium)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034663"(endoplasmic reticulum chaperone complex)|go:"GO:0034975"(protein folding in endoplasmic reticulum)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0042470"(melanosome)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0046598"(positive regulation of viral entry into host cell)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0098761"(cellular response to interleukin-7)|go:"GO:1900026"(positive regulation of substrate adhesion-dependent cell spreading)|go:"GO:1902175"(regulation of oxidative stress-induced intrinsic apoptotic signaling pathway)|interpro:IPR005788(Disulphide isomerase)|interpro:IPR005792(Protein disulphide isomerase)|interpro:IPR013766(Thioredoxin domain)|interpro:IPR017937|interpro:IPR036249|mint:P04785|reactome:R-RNO-1650814|reactome:R-RNO-3299685|reactome:R-RNO-381426|reactome:R-RNO-5358346|reactome:R-RNO-8866423|reactome:R-RNO-8957275|reactome:R-RNO-8963888|reactome:R-RNO-9020591|reactome:R-RNO-9020933	-	-	-	caution:"The participant EBI-349571(P68370) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919386(Q7TP47) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920972(Q5XIP9) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-916419(P11980) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919578(Q8R491) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920554(Q5U3Z7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920647(Q5U2X8) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920585(Q7TP24) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-779677(P05426) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-915744(P02454) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|agonist:Insulin was shown to increase or decrease GLUT4 protein interactions in specific cases.|comment:"Insulin decreased GLUT4 interactions with the following proteins: Q9ER30 (Sarcosin), P09527 (Rab-7), O88960 (N-ethylmaleimide sensitive), P09456 (PKA I regulatory subunit), P27881 (Hexokinase type II), P07872 (Acyl-coenzyme A oxidase), Q6DGF1 (Isocitrate dehydrogenase), Q9EQX9 (Ubiquitin-conjugating), Q63446 (Polyubiquitin), P24268 (Cathepsin D), Q91XW0 (Heat shock protein 86), Q5FVH0 (unknown), P58405 (Striatin 3), Q62667 (Major vault protein), Q66H50 (unknown), Q09167 (splicing factor), Q9JHU5 (Arfaptin 1)."|comment:"Insulin increased GLUT4 interaction with the following proteins:Q9Z1P2 (R-actinin-1), P45592 (Cofilin), Q9QXQ0 (R-actinin-4), P26473 (ADP-ribosylation factor), P26437 (ADP-ribosylation factor),   Q7TNP1 (Basigin 2), Q6P6R2 (Dihydrolipoamide dehydrogenase),   P04797 (GAPDH), Q63081 (Protein disulfide isomerase), P29457 (47 kDa heat shock protein), Q9R1J8 (Leprecan), O88638 (Putative eps protein),   Q64375 (Synaptonemal complex)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:NDPK - Interactions involving proteins containing InterPro domain IPR001564, Nucleoside diphosphate kinase, core.	taxid:10116(rat-l6)|taxid:10116(Rattus norvegicus)	-	2006/02/15	2021/11/30	rogid:PbFY2lfrty8yw40Jq7ShR7xfuV410116	rogid:nXaUDIKzWIRQ95lFxT0hB0T9enQ10116	intact-crc:44F3A2176D02515F|rigid:9RVm0UBcqQF4k06RGKO89Bg16Q8	false	myc tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P19357	uniprotkb:P04764	intact:EBI-915426|uniprotkb:P97900|ensembl:ENSRNOP00000023256	intact:EBI-915852|uniprotkb:Q66HI3|uniprotkb:Q6AYV3|uniprotkb:Q6P504|ensembl:ENSRNOP00000024106|ensembl:ENSRNOP00000073191	psi-mi:glut4_rat(display_long)|uniprotkb:Glucose transporter type 4, insulin-responsive(gene name synonym)|uniprotkb:Slc2a4(gene name)|psi-mi:Slc2a4(display_short)|uniprotkb:Glut4(gene name synonym)	psi-mi:enoa_rat(display_long)|uniprotkb:2-phospho-D-glycerate hydro-lyase(gene name synonym)|uniprotkb:Non-neural enolase(gene name synonym)|uniprotkb:Enolase 1(gene name synonym)|uniprotkb:Eno1(gene name)|psi-mi:Eno1(display_short)|uniprotkb:Eno-1(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Foster et al. (2006)	pubmed:16396496|mint:MINT-5218203	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-921030	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2711|refseq:NP_036883.1|refseq:XP_006246658.1|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007611"(learning or memory)|go:"GO:0007614"(short-term memory)|go:"GO:0007616"(long-term memory)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010021"(amylopectin biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031550"(positive regulation of brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044381"(glucose import in response to insulin stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046323"(glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0098694"(regulation of synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0098793"(presynapse)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002441("Glucose transporter, type 4 (GLUT4)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-189200|ensembl:ENSRNOG00000017226(gene)|ensembl:ENSRNOT00000023256(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)	rgd:2553|refseq:NP_001103378.1|refseq:NP_036686.2|ensembl:ENSRNOG00000017895(gene)|ensembl:ENSRNOT00000024106(transcript)|ensembl:ENSRNOT00000081579(transcript)|go:"GO:0000015"(phosphopyruvate hydratase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0003723"(RNA binding)|go:"GO:0004634"(phosphopyruvate hydratase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006096"(glycolytic process)|go:"GO:0009615"(response to virus)|go:"GO:0009986"(cell surface)|go:"GO:0010756"(positive regulation of plasminogen activation)|go:"GO:0016020"(membrane)|go:"GO:0019897"(extrinsic component of plasma membrane)|go:"GO:0019899"(enzyme binding)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030426"(growth cone)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0032889"(regulation of vacuole fusion, non-autophagic)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043005"(neuron projection)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045121"(membrane raft)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045933"(positive regulation of muscle contraction)|go:"GO:0051020"(GTPase binding)|go:"GO:0051099"(positive regulation of binding)|go:"GO:0061621"(canonical glycolysis)|go:"GO:0070371"(ERK1 and ERK2 cascade)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0097060"(synaptic membrane)|go:"GO:0098761"(cellular response to interleukin-7)|go:"GO:0099738"(cell cortex region)|go:"GO:1903298"(negative regulation of hypoxia-induced intrinsic apoptotic signaling pathway)|go:"GO:2001171"(positive regulation of ATP biosynthetic process)|interpro:IPR000941(Enolase)|interpro:IPR020809|interpro:IPR020810|interpro:IPR020811|interpro:IPR029017|interpro:IPR036849|mint:P04764|reactome:R-RNO-70171|reactome:R-RNO-70263	-	-	-	caution:"The participant EBI-349571(P68370) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919386(Q7TP47) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920972(Q5XIP9) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-916419(P11980) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919578(Q8R491) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920554(Q5U3Z7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920647(Q5U2X8) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920585(Q7TP24) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-779677(P05426) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-915744(P02454) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|agonist:Insulin was shown to increase or decrease GLUT4 protein interactions in specific cases.|comment:"Insulin decreased GLUT4 interactions with the following proteins: Q9ER30 (Sarcosin), P09527 (Rab-7), O88960 (N-ethylmaleimide sensitive), P09456 (PKA I regulatory subunit), P27881 (Hexokinase type II), P07872 (Acyl-coenzyme A oxidase), Q6DGF1 (Isocitrate dehydrogenase), Q9EQX9 (Ubiquitin-conjugating), Q63446 (Polyubiquitin), P24268 (Cathepsin D), Q91XW0 (Heat shock protein 86), Q5FVH0 (unknown), P58405 (Striatin 3), Q62667 (Major vault protein), Q66H50 (unknown), Q09167 (splicing factor), Q9JHU5 (Arfaptin 1)."|comment:"Insulin increased GLUT4 interaction with the following proteins:Q9Z1P2 (R-actinin-1), P45592 (Cofilin), Q9QXQ0 (R-actinin-4), P26473 (ADP-ribosylation factor), P26437 (ADP-ribosylation factor),   Q7TNP1 (Basigin 2), Q6P6R2 (Dihydrolipoamide dehydrogenase),   P04797 (GAPDH), Q63081 (Protein disulfide isomerase), P29457 (47 kDa heat shock protein), Q9R1J8 (Leprecan), O88638 (Putative eps protein),   Q64375 (Synaptonemal complex)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:NDPK - Interactions involving proteins containing InterPro domain IPR001564, Nucleoside diphosphate kinase, core.	taxid:10116(rat-l6)|taxid:10116(Rattus norvegicus)	-	2006/02/15	2021/11/30	rogid:PbFY2lfrty8yw40Jq7ShR7xfuV410116	rogid:JPjYBxy1gOmhfZso6+adhg5N8UM10116	intact-crc:44F3A2176D02515F|rigid:9RVm0UBcqQF4k06RGKO89Bg16Q8	false	myc tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P19357	uniprotkb:P04762	intact:EBI-915426|uniprotkb:P97900|ensembl:ENSRNOP00000023256	intact:EBI-915842|ensembl:ENSRNOP00000011230	psi-mi:glut4_rat(display_long)|uniprotkb:Glucose transporter type 4, insulin-responsive(gene name synonym)|uniprotkb:Slc2a4(gene name)|psi-mi:Slc2a4(display_short)|uniprotkb:Glut4(gene name synonym)	psi-mi:cata_rat(display_long)|uniprotkb:Cat(gene name)|psi-mi:Cat(display_short)|uniprotkb:Cas1(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Foster et al. (2006)	pubmed:16396496|mint:MINT-5218203	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-921030	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2711|refseq:NP_036883.1|refseq:XP_006246658.1|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007611"(learning or memory)|go:"GO:0007614"(short-term memory)|go:"GO:0007616"(long-term memory)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010021"(amylopectin biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031550"(positive regulation of brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044381"(glucose import in response to insulin stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046323"(glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0098694"(regulation of synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0098793"(presynapse)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002441("Glucose transporter, type 4 (GLUT4)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-189200|ensembl:ENSRNOG00000017226(gene)|ensembl:ENSRNOT00000023256(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)	go:"GO:0009060"(aerobic respiration)|go:"GO:0009314"(response to radiation)|go:"GO:0009411"(response to UV)|go:"GO:0009636"(response to toxic substance)|go:"GO:0009642"(response to light intensity)|go:"GO:0009650"(UV protection)|go:"GO:0010193"(response to ozone)|go:"GO:0010288"(response to lead ion)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0014823"(response to activity)|go:"GO:0014854"(response to inactivity)|go:"GO:0016209"(antioxidant activity)|go:"GO:0016684"(oxidoreductase activity, acting on peroxide as acceptor)|go:"GO:0019899"(enzyme binding)|ensembl:ENSRNOG00000008364(gene)|ensembl:ENSRNOT00000011230(transcript)|go:"GO:0000268"(peroxisome targeting sequence binding)|go:"GO:0000302"(response to reactive oxygen species)|go:"GO:0001657"(ureteric bud development)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001822"(kidney development)|go:"GO:0004046"(aminoacylase activity)|go:"GO:0004096"(catalase activity)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0005764"(lysosome)|go:"GO:0005777"(peroxisome)|go:"GO:0005778"(peroxisomal membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006641"(triglyceride metabolic process)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0007568"(aging)|go:"GO:0008203"(cholesterol metabolic process)|rgd:2279|refseq:NP_036652.1|go:"GO:0020027"(hemoglobin metabolic process)|go:"GO:0020037"(heme binding)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032355"(response to estradiol)|go:"GO:0032868"(response to insulin)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033189"(response to vitamin A)|go:"GO:0033197"(response to vitamin E)|go:"GO:0033591"(response to L-ascorbic acid)|go:"GO:0042493"|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0042744"(hydrogen peroxide catabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0045471"(response to ethanol)|go:"GO:0046686"(response to cadmium ion)|go:"GO:0046872"(metal ion binding)|go:"GO:0050661"(NADP binding)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051781"(positive regulation of cell division)|go:"GO:0055093"(response to hyperoxia)|go:"GO:0070542"(response to fatty acid)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0080184"(response to phenylpropanoid)|interpro:IPR002226(Catalase)|interpro:IPR010582(Catalase-related)|interpro:IPR011614(Catalase, N-terminal)|interpro:IPR018028|interpro:IPR020835|interpro:IPR024708|interpro:IPR024711|interpro:IPR040333|reactome:R-RNO-3299685|reactome:R-RNO-6798695|reactome:R-RNO-9033241	-	-	-	caution:"The participant EBI-349571(P68370) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919386(Q7TP47) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920972(Q5XIP9) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-916419(P11980) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919578(Q8R491) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920554(Q5U3Z7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920647(Q5U2X8) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920585(Q7TP24) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-779677(P05426) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-915744(P02454) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|agonist:Insulin was shown to increase or decrease GLUT4 protein interactions in specific cases.|comment:"Insulin decreased GLUT4 interactions with the following proteins: Q9ER30 (Sarcosin), P09527 (Rab-7), O88960 (N-ethylmaleimide sensitive), P09456 (PKA I regulatory subunit), P27881 (Hexokinase type II), P07872 (Acyl-coenzyme A oxidase), Q6DGF1 (Isocitrate dehydrogenase), Q9EQX9 (Ubiquitin-conjugating), Q63446 (Polyubiquitin), P24268 (Cathepsin D), Q91XW0 (Heat shock protein 86), Q5FVH0 (unknown), P58405 (Striatin 3), Q62667 (Major vault protein), Q66H50 (unknown), Q09167 (splicing factor), Q9JHU5 (Arfaptin 1)."|comment:"Insulin increased GLUT4 interaction with the following proteins:Q9Z1P2 (R-actinin-1), P45592 (Cofilin), Q9QXQ0 (R-actinin-4), P26473 (ADP-ribosylation factor), P26437 (ADP-ribosylation factor),   Q7TNP1 (Basigin 2), Q6P6R2 (Dihydrolipoamide dehydrogenase),   P04797 (GAPDH), Q63081 (Protein disulfide isomerase), P29457 (47 kDa heat shock protein), Q9R1J8 (Leprecan), O88638 (Putative eps protein),   Q64375 (Synaptonemal complex)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:NDPK - Interactions involving proteins containing InterPro domain IPR001564, Nucleoside diphosphate kinase, core.	taxid:10116(rat-l6)|taxid:10116(Rattus norvegicus)	-	2006/02/15	2021/11/30	rogid:PbFY2lfrty8yw40Jq7ShR7xfuV410116	rogid:dvt8S8neDN5cx0C+L0THuo00/BA10116	intact-crc:44F3A2176D02515F|rigid:9RVm0UBcqQF4k06RGKO89Bg16Q8	false	myc tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P19357	uniprotkb:Q3KRE8	intact:EBI-915426|uniprotkb:P97900|ensembl:ENSRNOP00000023256	intact:EBI-349199|ensembl:ENSRNOP00000023582|ensembl:ENSRNOP00000073323|uniprotkb:A3KMR7|uniprotkb:P04691	psi-mi:glut4_rat(display_long)|uniprotkb:Glucose transporter type 4, insulin-responsive(gene name synonym)|uniprotkb:Slc2a4(gene name)|psi-mi:Slc2a4(display_short)|uniprotkb:Glut4(gene name synonym)	psi-mi:tbb2b_rat(display_long)|uniprotkb:T beta-15(gene name synonym)|uniprotkb:Tubb2b(gene name)|psi-mi:Tubb2b(display_short)|uniprotkb:Tubb2a(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Foster et al. (2006)	pubmed:16396496|mint:MINT-5218203	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-921030	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2711|refseq:NP_036883.1|refseq:XP_006246658.1|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007611"(learning or memory)|go:"GO:0007614"(short-term memory)|go:"GO:0007616"(long-term memory)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010021"(amylopectin biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031550"(positive regulation of brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044381"(glucose import in response to insulin stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046323"(glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0098694"(regulation of synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0098793"(presynapse)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002441("Glucose transporter, type 4 (GLUT4)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-189200|ensembl:ENSRNOG00000017226(gene)|ensembl:ENSRNOT00000023256(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)	rgd:1309427|refseq:NP_001013908.2|ensembl:ENSRNOG00000017445(gene)|ensembl:ENSRNOT00000023582(transcript)|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0001764"(neuron migration)|go:"GO:0005200"(structural constituent of cytoskeleton)|go:"GO:0005525"(GTP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005874"(microtubule)|go:"GO:0007017"(microtubule-based process)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:1902669"(positive regulation of axon guidance)|go:"GO:1990403"(embryonic brain development)|interpro:IPR000217(Tubulin)|interpro:IPR002453(Beta tubulin)|interpro:IPR003008(Tubulin/FtsZ, GTPase)|interpro:IPR008280(Tubulin/FtsZ, C-terminal)|interpro:IPR013838(Beta tubulin, autoregulation binding site)|ensembl:ENSRNOT00000083705(transcript)|reactome:R-RNO-5626467|interpro:IPR017975|interpro:IPR018316|reactome:R-RNO-5663220|reactome:R-RNO-6807878|reactome:R-RNO-6811434|interpro:IPR023123|reactome:R-RNO-6811436|reactome:R-RNO-68877|reactome:R-RNO-8852276|reactome:R-RNO-8955332|interpro:IPR036525|interpro:IPR037103|mint:Q3KRE8|reactome:R-RNO-190840|reactome:R-RNO-9646399|reactome:R-RNO-9648025|reactome:R-RNO-9668328|reactome:R-RNO-2132295|reactome:R-RNO-2467813|reactome:R-RNO-2500257|reactome:R-RNO-3371497|reactome:R-RNO-380320|reactome:R-RNO-437239|reactome:R-RNO-5610787|reactome:R-RNO-5617833|reactome:R-RNO-5620924|reactome:R-RNO-983189	-	-	-	caution:"The participant EBI-349571(P68370) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919386(Q7TP47) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920972(Q5XIP9) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-916419(P11980) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919578(Q8R491) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920554(Q5U3Z7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920647(Q5U2X8) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920585(Q7TP24) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-779677(P05426) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-915744(P02454) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|agonist:Insulin was shown to increase or decrease GLUT4 protein interactions in specific cases.|comment:"Insulin decreased GLUT4 interactions with the following proteins: Q9ER30 (Sarcosin), P09527 (Rab-7), O88960 (N-ethylmaleimide sensitive), P09456 (PKA I regulatory subunit), P27881 (Hexokinase type II), P07872 (Acyl-coenzyme A oxidase), Q6DGF1 (Isocitrate dehydrogenase), Q9EQX9 (Ubiquitin-conjugating), Q63446 (Polyubiquitin), P24268 (Cathepsin D), Q91XW0 (Heat shock protein 86), Q5FVH0 (unknown), P58405 (Striatin 3), Q62667 (Major vault protein), Q66H50 (unknown), Q09167 (splicing factor), Q9JHU5 (Arfaptin 1)."|comment:"Insulin increased GLUT4 interaction with the following proteins:Q9Z1P2 (R-actinin-1), P45592 (Cofilin), Q9QXQ0 (R-actinin-4), P26473 (ADP-ribosylation factor), P26437 (ADP-ribosylation factor),   Q7TNP1 (Basigin 2), Q6P6R2 (Dihydrolipoamide dehydrogenase),   P04797 (GAPDH), Q63081 (Protein disulfide isomerase), P29457 (47 kDa heat shock protein), Q9R1J8 (Leprecan), O88638 (Putative eps protein),   Q64375 (Synaptonemal complex)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:NDPK - Interactions involving proteins containing InterPro domain IPR001564, Nucleoside diphosphate kinase, core.	taxid:10116(rat-l6)|taxid:10116(Rattus norvegicus)	-	2006/02/15	2021/11/30	rogid:PbFY2lfrty8yw40Jq7ShR7xfuV410116	rogid:sluQMryNuOvp6xlV558+agiRwvE10116	intact-crc:44F3A2176D02515F|rigid:9RVm0UBcqQF4k06RGKO89Bg16Q8	false	myc tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P19357	uniprotkb:P62890	intact:EBI-915426|uniprotkb:P97900|ensembl:ENSRNOP00000023256	intact:EBI-437905|ensembl:ENSRNOP00000054398|ensembl:ENSRNOP00000072453|uniprotkb:P04645	psi-mi:glut4_rat(display_long)|uniprotkb:Glucose transporter type 4, insulin-responsive(gene name synonym)|uniprotkb:Slc2a4(gene name)|psi-mi:Slc2a4(display_short)|uniprotkb:Glut4(gene name synonym)	psi-mi:rl30_rat(display_long)|uniprotkb:Rpl30(gene name)|psi-mi:Rpl30(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Foster et al. (2006)	pubmed:16396496|mint:MINT-5218203	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-921030	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2711|refseq:NP_036883.1|refseq:XP_006246658.1|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007611"(learning or memory)|go:"GO:0007614"(short-term memory)|go:"GO:0007616"(long-term memory)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010021"(amylopectin biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031550"(positive regulation of brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044381"(glucose import in response to insulin stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046323"(glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0098694"(regulation of synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0098793"(presynapse)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002441("Glucose transporter, type 4 (GLUT4)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-189200|ensembl:ENSRNOG00000017226(gene)|ensembl:ENSRNOT00000023256(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)	ensembl:ENSRNOG00000005975(gene)|ensembl:ENSRNOG00000032825(gene)|ensembl:ENSRNOT00000042688(transcript)|ensembl:ENSRNOT00000057587(transcript)|go:"GO:0002181"(cytoplasmic translation)|go:"GO:0003723"(RNA binding)|go:"GO:0003735"(structural constituent of ribosome)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0005840"(ribosome)|go:"GO:0014069"(postsynaptic density)|go:"GO:0022625"(cytosolic large ribosomal subunit)|go:"GO:0022626"(cytosolic ribosome)|go:"GO:0031640"(killing of cells of another organism)|go:"GO:0035368"(selenocysteine insertion sequence binding)|go:"GO:0042788"(polysomal ribosome)|go:"GO:0050829"(defense response to Gram-negative bacterium)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0097421"(liver regeneration)|go:"GO:1904571"(positive regulation of selenocysteine incorporation)|interpro:IPR000231(Ribosomal protein L30e)|interpro:IPR004038(Ribosomal protein L7Ae/L30e/S12e/Gadd45)|interpro:IPR022991|interpro:IPR029064|interpro:IPR039109|reactome:R-RNO-156827|reactome:R-RNO-1799339|reactome:R-RNO-6791226|reactome:R-RNO-72689|reactome:R-RNO-72706|reactome:R-RNO-975956|reactome:R-RNO-975957|rgd:621201|refseq:NP_073190.1|refseq:XP_002727755.1|refseq:XP_003752376.1	-	-	-	caution:"The participant EBI-349571(P68370) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919386(Q7TP47) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920972(Q5XIP9) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-916419(P11980) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919578(Q8R491) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920554(Q5U3Z7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920647(Q5U2X8) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920585(Q7TP24) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-779677(P05426) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-915744(P02454) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|agonist:Insulin was shown to increase or decrease GLUT4 protein interactions in specific cases.|comment:"Insulin decreased GLUT4 interactions with the following proteins: Q9ER30 (Sarcosin), P09527 (Rab-7), O88960 (N-ethylmaleimide sensitive), P09456 (PKA I regulatory subunit), P27881 (Hexokinase type II), P07872 (Acyl-coenzyme A oxidase), Q6DGF1 (Isocitrate dehydrogenase), Q9EQX9 (Ubiquitin-conjugating), Q63446 (Polyubiquitin), P24268 (Cathepsin D), Q91XW0 (Heat shock protein 86), Q5FVH0 (unknown), P58405 (Striatin 3), Q62667 (Major vault protein), Q66H50 (unknown), Q09167 (splicing factor), Q9JHU5 (Arfaptin 1)."|comment:"Insulin increased GLUT4 interaction with the following proteins:Q9Z1P2 (R-actinin-1), P45592 (Cofilin), Q9QXQ0 (R-actinin-4), P26473 (ADP-ribosylation factor), P26437 (ADP-ribosylation factor),   Q7TNP1 (Basigin 2), Q6P6R2 (Dihydrolipoamide dehydrogenase),   P04797 (GAPDH), Q63081 (Protein disulfide isomerase), P29457 (47 kDa heat shock protein), Q9R1J8 (Leprecan), O88638 (Putative eps protein),   Q64375 (Synaptonemal complex)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:NDPK - Interactions involving proteins containing InterPro domain IPR001564, Nucleoside diphosphate kinase, core.	taxid:10116(rat-l6)|taxid:10116(Rattus norvegicus)	-	2006/02/15	2021/11/30	rogid:PbFY2lfrty8yw40Jq7ShR7xfuV410116	rogid:xR9LwYg6N7m9njT1pYumOPKZVu410116	intact-crc:44F3A2176D02515F|rigid:9RVm0UBcqQF4k06RGKO89Bg16Q8	false	myc tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P19357	uniprotkb:P04644	intact:EBI-915426|uniprotkb:P97900|ensembl:ENSRNOP00000023256	intact:EBI-915836|uniprotkb:Q6PDV2|ensembl:ENSRNOP00000064320	psi-mi:glut4_rat(display_long)|uniprotkb:Glucose transporter type 4, insulin-responsive(gene name synonym)|uniprotkb:Slc2a4(gene name)|psi-mi:Slc2a4(display_short)|uniprotkb:Glut4(gene name synonym)	psi-mi:rs17_rat(display_long)|uniprotkb:Rps17(gene name)|psi-mi:Rps17(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Foster et al. (2006)	pubmed:16396496|mint:MINT-5218203	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-921030	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2711|refseq:NP_036883.1|refseq:XP_006246658.1|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007611"(learning or memory)|go:"GO:0007614"(short-term memory)|go:"GO:0007616"(long-term memory)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010021"(amylopectin biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031550"(positive regulation of brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044381"(glucose import in response to insulin stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046323"(glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0098694"(regulation of synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0098793"(presynapse)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002441("Glucose transporter, type 4 (GLUT4)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-189200|ensembl:ENSRNOG00000017226(gene)|ensembl:ENSRNOT00000023256(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)	rgd:62027|refseq:NP_058848.2|reactome:R-RNO-975956|reactome:R-RNO-975957|ensembl:ENSRNOG00000045885(gene)|ensembl:ENSRNOT00000073068(transcript)|go:"GO:0003735"(structural constituent of ribosome)|go:"GO:0006364"(rRNA processing)|go:"GO:0006412"(translation)|go:"GO:0022626"(cytosolic ribosome)|go:"GO:0022627"(cytosolic small ribosomal subunit)|go:"GO:0034101"(erythrocyte homeostasis)|go:"GO:0042274"(ribosomal small subunit biogenesis)|go:"GO:0045202"(synapse)|interpro:IPR001210(Ribosomal protein S17e)|interpro:IPR018273|interpro:IPR036401|mint:P04644|reactome:R-RNO-156827|reactome:R-RNO-1799339|reactome:R-RNO-6791226|reactome:R-RNO-72649|reactome:R-RNO-72689|reactome:R-RNO-72695|reactome:R-RNO-72702|reactome:R-RNO-72706|refseq:XP_006226597.1|refseq:XP_006243666.1	-	-	-	caution:"The participant EBI-349571(P68370) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919386(Q7TP47) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920972(Q5XIP9) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-916419(P11980) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919578(Q8R491) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920554(Q5U3Z7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920647(Q5U2X8) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920585(Q7TP24) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-779677(P05426) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-915744(P02454) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|agonist:Insulin was shown to increase or decrease GLUT4 protein interactions in specific cases.|comment:"Insulin decreased GLUT4 interactions with the following proteins: Q9ER30 (Sarcosin), P09527 (Rab-7), O88960 (N-ethylmaleimide sensitive), P09456 (PKA I regulatory subunit), P27881 (Hexokinase type II), P07872 (Acyl-coenzyme A oxidase), Q6DGF1 (Isocitrate dehydrogenase), Q9EQX9 (Ubiquitin-conjugating), Q63446 (Polyubiquitin), P24268 (Cathepsin D), Q91XW0 (Heat shock protein 86), Q5FVH0 (unknown), P58405 (Striatin 3), Q62667 (Major vault protein), Q66H50 (unknown), Q09167 (splicing factor), Q9JHU5 (Arfaptin 1)."|comment:"Insulin increased GLUT4 interaction with the following proteins:Q9Z1P2 (R-actinin-1), P45592 (Cofilin), Q9QXQ0 (R-actinin-4), P26473 (ADP-ribosylation factor), P26437 (ADP-ribosylation factor),   Q7TNP1 (Basigin 2), Q6P6R2 (Dihydrolipoamide dehydrogenase),   P04797 (GAPDH), Q63081 (Protein disulfide isomerase), P29457 (47 kDa heat shock protein), Q9R1J8 (Leprecan), O88638 (Putative eps protein),   Q64375 (Synaptonemal complex)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:NDPK - Interactions involving proteins containing InterPro domain IPR001564, Nucleoside diphosphate kinase, core.	taxid:10116(rat-l6)|taxid:10116(Rattus norvegicus)	-	2006/02/15	2021/11/30	rogid:PbFY2lfrty8yw40Jq7ShR7xfuV410116	rogid:1PxCnfXPjXqTHxn6Cb6Hplv/HeU10116	intact-crc:44F3A2176D02515F|rigid:9RVm0UBcqQF4k06RGKO89Bg16Q8	false	myc tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P19357	uniprotkb:P04642	intact:EBI-915426|uniprotkb:P97900|ensembl:ENSRNOP00000023256	intact:EBI-349226|ensembl:ENSRNOP00000017468	psi-mi:glut4_rat(display_long)|uniprotkb:Glucose transporter type 4, insulin-responsive(gene name synonym)|uniprotkb:Slc2a4(gene name)|psi-mi:Slc2a4(display_short)|uniprotkb:Glut4(gene name synonym)	psi-mi:ldha_rat(display_long)|uniprotkb:Ldha(gene name)|psi-mi:Ldha(display_short)|uniprotkb:Ldh-1(gene name synonym)|uniprotkb:Ldh1(gene name synonym)|uniprotkb:LDH muscle subunit(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Foster et al. (2006)	pubmed:16396496|mint:MINT-5218203	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-921030	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2711|refseq:NP_036883.1|refseq:XP_006246658.1|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007611"(learning or memory)|go:"GO:0007614"(short-term memory)|go:"GO:0007616"(long-term memory)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010021"(amylopectin biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031550"(positive regulation of brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044381"(glucose import in response to insulin stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046323"(glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0098694"(regulation of synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0098793"(presynapse)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002441("Glucose transporter, type 4 (GLUT4)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-189200|ensembl:ENSRNOG00000017226(gene)|ensembl:ENSRNOT00000023256(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)	rgd:2996|refseq:NP_058721.1|go:"GO:0004459"(L-lactate dehydrogenase activity)|go:"GO:0005829"(cytosol)|go:"GO:0006089"(lactate metabolic process)|go:"GO:0007584"(response to nutrient)|go:"GO:0009749"(response to glucose)|go:"GO:0014070"(response to organic cyclic compound)|go:"GO:0019661"(glucose catabolic process to lactate via pyruvate)|go:"GO:0019674"(NAD metabolic process)|go:"GO:0019900"(kinase binding)|go:"GO:0031668"(cellular response to extracellular stimulus)|go:"GO:0035686"(sperm fibrous sheath)|go:"GO:0042493"|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043627"(response to estrogen)|ensembl:ENSRNOG00000013009(gene)|ensembl:ENSRNOT00000017468(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0004457"(lactate dehydrogenase activity)|go:"GO:0048569"(post-embryonic animal organ development)|go:"GO:0051287"(NAD binding)|go:"GO:0051591"(response to cAMP)|interpro:IPR001236(Lactate/malate dehydrogenase)|interpro:IPR001557(L-lactate/malate dehydrogenase)|interpro:IPR011304(L-lactate dehydrogenase)|interpro:IPR015955(Lactate dehydrogenase/glycoside hydrolase, family 4, C-terminal)|interpro:IPR018177|interpro:IPR022383|interpro:IPR036291|mint:P04642|rcsb pdb:4AJ1|rcsb pdb:4AJ2|rcsb pdb:4AJ4|rcsb pdb:4AJE|rcsb pdb:4AJH|rcsb pdb:4AJI|rcsb pdb:4AJJ|rcsb pdb:4AJK|rcsb pdb:4AJL|rcsb pdb:4AJN|rcsb pdb:4AJO|rcsb pdb:4AL4|rcsb pdb:5ES3|reactome:R-RNO-70268	-	-	-	caution:"The participant EBI-349571(P68370) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919386(Q7TP47) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920972(Q5XIP9) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-916419(P11980) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919578(Q8R491) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920554(Q5U3Z7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920647(Q5U2X8) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920585(Q7TP24) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-779677(P05426) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-915744(P02454) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|agonist:Insulin was shown to increase or decrease GLUT4 protein interactions in specific cases.|comment:"Insulin decreased GLUT4 interactions with the following proteins: Q9ER30 (Sarcosin), P09527 (Rab-7), O88960 (N-ethylmaleimide sensitive), P09456 (PKA I regulatory subunit), P27881 (Hexokinase type II), P07872 (Acyl-coenzyme A oxidase), Q6DGF1 (Isocitrate dehydrogenase), Q9EQX9 (Ubiquitin-conjugating), Q63446 (Polyubiquitin), P24268 (Cathepsin D), Q91XW0 (Heat shock protein 86), Q5FVH0 (unknown), P58405 (Striatin 3), Q62667 (Major vault protein), Q66H50 (unknown), Q09167 (splicing factor), Q9JHU5 (Arfaptin 1)."|comment:"Insulin increased GLUT4 interaction with the following proteins:Q9Z1P2 (R-actinin-1), P45592 (Cofilin), Q9QXQ0 (R-actinin-4), P26473 (ADP-ribosylation factor), P26437 (ADP-ribosylation factor),   Q7TNP1 (Basigin 2), Q6P6R2 (Dihydrolipoamide dehydrogenase),   P04797 (GAPDH), Q63081 (Protein disulfide isomerase), P29457 (47 kDa heat shock protein), Q9R1J8 (Leprecan), O88638 (Putative eps protein),   Q64375 (Synaptonemal complex)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:NDPK - Interactions involving proteins containing InterPro domain IPR001564, Nucleoside diphosphate kinase, core.	taxid:10116(rat-l6)|taxid:10116(Rattus norvegicus)	-	2006/02/15	2021/11/30	rogid:PbFY2lfrty8yw40Jq7ShR7xfuV410116	rogid:eKheC3CX/6TCkaYKpBsKggGzDXQ10116	intact-crc:44F3A2176D02515F|rigid:9RVm0UBcqQF4k06RGKO89Bg16Q8	false	myc tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P19357	uniprotkb:P04636	intact:EBI-915426|uniprotkb:P97900|ensembl:ENSRNOP00000023256	intact:EBI-349293|ensembl:ENSRNOP00000001958|uniprotkb:Q6GSM4	psi-mi:glut4_rat(display_long)|uniprotkb:Glucose transporter type 4, insulin-responsive(gene name synonym)|uniprotkb:Slc2a4(gene name)|psi-mi:Slc2a4(display_short)|uniprotkb:Glut4(gene name synonym)	psi-mi:mdhm_rat(display_long)|uniprotkb:Mdh2(gene name)|psi-mi:Mdh2(display_short)|uniprotkb:Mor1(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Foster et al. (2006)	pubmed:16396496|mint:MINT-5218203	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-921030	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2711|refseq:NP_036883.1|refseq:XP_006246658.1|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007611"(learning or memory)|go:"GO:0007614"(short-term memory)|go:"GO:0007616"(long-term memory)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010021"(amylopectin biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031550"(positive regulation of brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044381"(glucose import in response to insulin stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046323"(glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0098694"(regulation of synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0098793"(presynapse)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002441("Glucose transporter, type 4 (GLUT4)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-189200|ensembl:ENSRNOG00000017226(gene)|ensembl:ENSRNOT00000023256(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)	rgd:619719|refseq:NP_112413.2|ensembl:ENSRNOG00000001440(gene)|ensembl:ENSRNOT00000001958(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005975"(carbohydrate metabolic process)|go:"GO:0006099"(tricarboxylic acid cycle)|go:"GO:0006107"(oxaloacetate metabolic process)|go:"GO:0006108"(malate metabolic process)|go:"GO:0006734"(NADH metabolic process)|go:"GO:0009060"(aerobic respiration)|go:"GO:0016020"(membrane)|go:"GO:0016615"(malate dehydrogenase activity)|go:"GO:0030060"(L-malate dehydrogenase activity)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043621"(protein self-association)|go:"GO:0046554"("malate dehydrogenase (NADP+) activity")|interpro:IPR001236(Lactate/malate dehydrogenase)|interpro:IPR001252(Malate dehydrogenase, active site)|interpro:IPR001557(L-lactate/malate dehydrogenase)|interpro:IPR010097(Malate dehydrogenase, NAD-dependent, eukaryotes and gamma proteobacteria)|interpro:IPR015955(Lactate dehydrogenase/glycoside hydrolase, family 4, C-terminal)|interpro:IPR022383|interpro:IPR036291|mint:P04636|reactome:R-RNO-70263|reactome:R-RNO-71403	-	-	-	caution:"The participant EBI-349571(P68370) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919386(Q7TP47) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920972(Q5XIP9) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-916419(P11980) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919578(Q8R491) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920554(Q5U3Z7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920647(Q5U2X8) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920585(Q7TP24) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-779677(P05426) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-915744(P02454) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|agonist:Insulin was shown to increase or decrease GLUT4 protein interactions in specific cases.|comment:"Insulin decreased GLUT4 interactions with the following proteins: Q9ER30 (Sarcosin), P09527 (Rab-7), O88960 (N-ethylmaleimide sensitive), P09456 (PKA I regulatory subunit), P27881 (Hexokinase type II), P07872 (Acyl-coenzyme A oxidase), Q6DGF1 (Isocitrate dehydrogenase), Q9EQX9 (Ubiquitin-conjugating), Q63446 (Polyubiquitin), P24268 (Cathepsin D), Q91XW0 (Heat shock protein 86), Q5FVH0 (unknown), P58405 (Striatin 3), Q62667 (Major vault protein), Q66H50 (unknown), Q09167 (splicing factor), Q9JHU5 (Arfaptin 1)."|comment:"Insulin increased GLUT4 interaction with the following proteins:Q9Z1P2 (R-actinin-1), P45592 (Cofilin), Q9QXQ0 (R-actinin-4), P26473 (ADP-ribosylation factor), P26437 (ADP-ribosylation factor),   Q7TNP1 (Basigin 2), Q6P6R2 (Dihydrolipoamide dehydrogenase),   P04797 (GAPDH), Q63081 (Protein disulfide isomerase), P29457 (47 kDa heat shock protein), Q9R1J8 (Leprecan), O88638 (Putative eps protein),   Q64375 (Synaptonemal complex)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:NDPK - Interactions involving proteins containing InterPro domain IPR001564, Nucleoside diphosphate kinase, core.	taxid:10116(rat-l6)|taxid:10116(Rattus norvegicus)	-	2006/02/15	2021/11/30	rogid:PbFY2lfrty8yw40Jq7ShR7xfuV410116	rogid:Sa/YbZ/4mSQwdbOEyVs+4XfoUMg10116	intact-crc:44F3A2176D02515F|rigid:9RVm0UBcqQF4k06RGKO89Bg16Q8	false	myc tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P19357	uniprotkb:P04466	intact:EBI-915426|uniprotkb:P97900|ensembl:ENSRNOP00000023256	intact:EBI-915831|ensembl:ENSRNOP00000023944	psi-mi:glut4_rat(display_long)|uniprotkb:Glucose transporter type 4, insulin-responsive(gene name synonym)|uniprotkb:Slc2a4(gene name)|psi-mi:Slc2a4(display_short)|uniprotkb:Glut4(gene name synonym)	psi-mi:mlrs_rat(display_long)|uniprotkb:Fast skeletal myosin light chain 2(gene name synonym)|uniprotkb:DTNB(gene name synonym)|uniprotkb:Mylpf(gene name)|psi-mi:Mylpf(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Foster et al. (2006)	pubmed:16396496|mint:MINT-5218203	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-921030	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2711|refseq:NP_036883.1|refseq:XP_006246658.1|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007611"(learning or memory)|go:"GO:0007614"(short-term memory)|go:"GO:0007616"(long-term memory)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010021"(amylopectin biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031550"(positive regulation of brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044381"(glucose import in response to insulin stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046323"(glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0098694"(regulation of synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0098793"(presynapse)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002441("Glucose transporter, type 4 (GLUT4)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-189200|ensembl:ENSRNOG00000017226(gene)|ensembl:ENSRNOT00000023256(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)	rgd:3141|refseq:NP_036737.1|ensembl:ENSRNOG00000017645(gene)|ensembl:ENSRNOT00000023944(transcript)|go:"GO:0005509"(calcium ion binding)|go:"GO:0006936"(muscle contraction)|go:"GO:0006955"(immune response)|go:"GO:0007519"(skeletal muscle tissue development)|go:"GO:0008307"(structural constituent of muscle)|go:"GO:0016459"(myosin complex)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR011992(EF-Hand type)|interpro:IPR018247|reactome:R-RNO-445355	-	-	-	caution:"The participant EBI-349571(P68370) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919386(Q7TP47) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920972(Q5XIP9) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-916419(P11980) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919578(Q8R491) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920554(Q5U3Z7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920647(Q5U2X8) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920585(Q7TP24) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-779677(P05426) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-915744(P02454) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|agonist:Insulin was shown to increase or decrease GLUT4 protein interactions in specific cases.|comment:"Insulin decreased GLUT4 interactions with the following proteins: Q9ER30 (Sarcosin), P09527 (Rab-7), O88960 (N-ethylmaleimide sensitive), P09456 (PKA I regulatory subunit), P27881 (Hexokinase type II), P07872 (Acyl-coenzyme A oxidase), Q6DGF1 (Isocitrate dehydrogenase), Q9EQX9 (Ubiquitin-conjugating), Q63446 (Polyubiquitin), P24268 (Cathepsin D), Q91XW0 (Heat shock protein 86), Q5FVH0 (unknown), P58405 (Striatin 3), Q62667 (Major vault protein), Q66H50 (unknown), Q09167 (splicing factor), Q9JHU5 (Arfaptin 1)."|comment:"Insulin increased GLUT4 interaction with the following proteins:Q9Z1P2 (R-actinin-1), P45592 (Cofilin), Q9QXQ0 (R-actinin-4), P26473 (ADP-ribosylation factor), P26437 (ADP-ribosylation factor),   Q7TNP1 (Basigin 2), Q6P6R2 (Dihydrolipoamide dehydrogenase),   P04797 (GAPDH), Q63081 (Protein disulfide isomerase), P29457 (47 kDa heat shock protein), Q9R1J8 (Leprecan), O88638 (Putative eps protein),   Q64375 (Synaptonemal complex)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:NDPK - Interactions involving proteins containing InterPro domain IPR001564, Nucleoside diphosphate kinase, core.	taxid:10116(rat-l6)|taxid:10116(Rattus norvegicus)	-	2006/02/15	2021/11/30	rogid:PbFY2lfrty8yw40Jq7ShR7xfuV410116	rogid:I3Ex/34u7rrMRTkVm5s01+xWzr810116	intact-crc:44F3A2176D02515F|rigid:9RVm0UBcqQF4k06RGKO89Bg16Q8	false	myc tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P19357	uniprotkb:P04462	intact:EBI-915426|uniprotkb:P97900|ensembl:ENSRNOP00000023256	intact:EBI-915826	psi-mi:glut4_rat(display_long)|uniprotkb:Glucose transporter type 4, insulin-responsive(gene name synonym)|uniprotkb:Slc2a4(gene name)|psi-mi:Slc2a4(display_short)|uniprotkb:Glut4(gene name synonym)	psi-mi:myh8_rat(display_long)|uniprotkb:Myosin heavy chain 8(gene name synonym)|uniprotkb:Myosin heavy chain, skeletal muscle, perinatal(gene name synonym)|uniprotkb:Myh8(gene name)|psi-mi:Myh8(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Foster et al. (2006)	pubmed:16396496|mint:MINT-5218203	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-921030	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2711|refseq:NP_036883.1|refseq:XP_006246658.1|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007611"(learning or memory)|go:"GO:0007614"(short-term memory)|go:"GO:0007616"(long-term memory)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010021"(amylopectin biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031550"(positive regulation of brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044381"(glucose import in response to insulin stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046323"(glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0098694"(regulation of synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0098793"(presynapse)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002441("Glucose transporter, type 4 (GLUT4)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-189200|ensembl:ENSRNOG00000017226(gene)|ensembl:ENSRNOT00000023256(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)	interpro:IPR002928(Myosin tail)|rgd:620356|go:"GO:0000146"(microfilament motor activity)|go:"GO:0003009"(skeletal muscle contraction)|go:"GO:0003779"(actin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0016459"(myosin complex)|go:"GO:0030016"(myofibril)|go:"GO:0030049"(muscle filament sliding)|go:"GO:0032982"(myosin filament)|go:"GO:0046034"(ATP metabolic process)|interpro:IPR014751(DNA double-strand break repair and VJ recombination XRCC4, C-terminal)	-	-	-	caution:"The participant EBI-349571(P68370) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919386(Q7TP47) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920972(Q5XIP9) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-916419(P11980) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919578(Q8R491) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920554(Q5U3Z7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920647(Q5U2X8) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920585(Q7TP24) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-779677(P05426) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-915744(P02454) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|agonist:Insulin was shown to increase or decrease GLUT4 protein interactions in specific cases.|comment:"Insulin decreased GLUT4 interactions with the following proteins: Q9ER30 (Sarcosin), P09527 (Rab-7), O88960 (N-ethylmaleimide sensitive), P09456 (PKA I regulatory subunit), P27881 (Hexokinase type II), P07872 (Acyl-coenzyme A oxidase), Q6DGF1 (Isocitrate dehydrogenase), Q9EQX9 (Ubiquitin-conjugating), Q63446 (Polyubiquitin), P24268 (Cathepsin D), Q91XW0 (Heat shock protein 86), Q5FVH0 (unknown), P58405 (Striatin 3), Q62667 (Major vault protein), Q66H50 (unknown), Q09167 (splicing factor), Q9JHU5 (Arfaptin 1)."|comment:"Insulin increased GLUT4 interaction with the following proteins:Q9Z1P2 (R-actinin-1), P45592 (Cofilin), Q9QXQ0 (R-actinin-4), P26473 (ADP-ribosylation factor), P26437 (ADP-ribosylation factor),   Q7TNP1 (Basigin 2), Q6P6R2 (Dihydrolipoamide dehydrogenase),   P04797 (GAPDH), Q63081 (Protein disulfide isomerase), P29457 (47 kDa heat shock protein), Q9R1J8 (Leprecan), O88638 (Putative eps protein),   Q64375 (Synaptonemal complex)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:NDPK - Interactions involving proteins containing InterPro domain IPR001564, Nucleoside diphosphate kinase, core.	taxid:10116(rat-l6)|taxid:10116(Rattus norvegicus)	-	2006/02/15	2021/11/30	rogid:PbFY2lfrty8yw40Jq7ShR7xfuV410116	rogid:aWzoWaJxdTbcisdkPkS9YMYNpMQ10116	intact-crc:44F3A2176D02515F|rigid:9RVm0UBcqQF4k06RGKO89Bg16Q8	false	myc tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P19357	uniprotkb:P04218	intact:EBI-915426|uniprotkb:P97900|ensembl:ENSRNOP00000023256	intact:EBI-915817	psi-mi:glut4_rat(display_long)|uniprotkb:Glucose transporter type 4, insulin-responsive(gene name synonym)|uniprotkb:Slc2a4(gene name)|psi-mi:Slc2a4(display_short)|uniprotkb:Glut4(gene name synonym)	psi-mi:ox2g_rat(display_long)|uniprotkb:MRC OX-2 antigen(gene name synonym)|uniprotkb:Cd200(gene name)|psi-mi:Cd200(display_short)|uniprotkb:Mox2(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Foster et al. (2006)	pubmed:16396496|mint:MINT-5218203	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-921030	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2711|refseq:NP_036883.1|refseq:XP_006246658.1|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007611"(learning or memory)|go:"GO:0007614"(short-term memory)|go:"GO:0007616"(long-term memory)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010021"(amylopectin biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031550"(positive regulation of brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044381"(glucose import in response to insulin stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046323"(glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0098694"(regulation of synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0098793"(presynapse)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002441("Glucose transporter, type 4 (GLUT4)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-189200|ensembl:ENSRNOG00000017226(gene)|ensembl:ENSRNOT00000023256(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)	go:"GO:2000405"(negative regulation of T cell migration)|reactome:R-RNO-198933|go:"GO:0005886"(plasma membrane)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009986"(cell surface)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030424"(axon)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0032793"(positive regulation of CREB transcription factor activity)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043031"(negative regulation of macrophage activation)|go:"GO:0044297"(cell body)|go:"GO:0050776"(regulation of immune response)|go:"GO:0071636"(positive regulation of transforming growth factor beta production)|go:"GO:0086080"(protein binding involved in heterotypic cell-cell adhesion)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0150072"(positive regulation of arginase activity)|go:"GO:0150074"(positive regulation of protein-glutamine gamma-glutamyltransferase activity)|go:"GO:0150077"(regulation of neuroinflammatory response)|go:"GO:0150079"(negative regulation of neuroinflammatory response)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1904465"(negative regulation of matrix metallopeptidase secretion)|go:"GO:1905522"(negative regulation of macrophage migration)|mint:P04218|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR033321|rgd:3104|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR036179	-	-	-	caution:"The participant EBI-349571(P68370) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919386(Q7TP47) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920972(Q5XIP9) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-916419(P11980) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919578(Q8R491) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920554(Q5U3Z7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920647(Q5U2X8) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920585(Q7TP24) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-779677(P05426) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-915744(P02454) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|agonist:Insulin was shown to increase or decrease GLUT4 protein interactions in specific cases.|comment:"Insulin decreased GLUT4 interactions with the following proteins: Q9ER30 (Sarcosin), P09527 (Rab-7), O88960 (N-ethylmaleimide sensitive), P09456 (PKA I regulatory subunit), P27881 (Hexokinase type II), P07872 (Acyl-coenzyme A oxidase), Q6DGF1 (Isocitrate dehydrogenase), Q9EQX9 (Ubiquitin-conjugating), Q63446 (Polyubiquitin), P24268 (Cathepsin D), Q91XW0 (Heat shock protein 86), Q5FVH0 (unknown), P58405 (Striatin 3), Q62667 (Major vault protein), Q66H50 (unknown), Q09167 (splicing factor), Q9JHU5 (Arfaptin 1)."|comment:"Insulin increased GLUT4 interaction with the following proteins:Q9Z1P2 (R-actinin-1), P45592 (Cofilin), Q9QXQ0 (R-actinin-4), P26473 (ADP-ribosylation factor), P26437 (ADP-ribosylation factor),   Q7TNP1 (Basigin 2), Q6P6R2 (Dihydrolipoamide dehydrogenase),   P04797 (GAPDH), Q63081 (Protein disulfide isomerase), P29457 (47 kDa heat shock protein), Q9R1J8 (Leprecan), O88638 (Putative eps protein),   Q64375 (Synaptonemal complex)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:NDPK - Interactions involving proteins containing InterPro domain IPR001564, Nucleoside diphosphate kinase, core.	taxid:10116(rat-l6)|taxid:10116(Rattus norvegicus)	-	2006/02/15	2021/11/30	rogid:PbFY2lfrty8yw40Jq7ShR7xfuV410116	rogid:BHy/iOl1Toxvv9wigUj/l80cVsA10116	intact-crc:44F3A2176D02515F|rigid:9RVm0UBcqQF4k06RGKO89Bg16Q8	false	myc tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P19357	uniprotkb:P04182	intact:EBI-915426|uniprotkb:P97900|ensembl:ENSRNOP00000023256	intact:EBI-915810|uniprotkb:Q6LDF6|uniprotkb:Q6LDF7|ensembl:ENSRNOP00000022628	psi-mi:glut4_rat(display_long)|uniprotkb:Glucose transporter type 4, insulin-responsive(gene name synonym)|uniprotkb:Slc2a4(gene name)|psi-mi:Slc2a4(display_short)|uniprotkb:Glut4(gene name synonym)	psi-mi:oat_rat(display_long)|uniprotkb:Ornithine--oxo-acid aminotransferase(gene name synonym)|uniprotkb:Oat(gene name)|psi-mi:Oat(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Foster et al. (2006)	pubmed:16396496|mint:MINT-5218203	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-921030	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2711|refseq:NP_036883.1|refseq:XP_006246658.1|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007611"(learning or memory)|go:"GO:0007614"(short-term memory)|go:"GO:0007616"(long-term memory)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010021"(amylopectin biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031550"(positive regulation of brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044381"(glucose import in response to insulin stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046323"(glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0098694"(regulation of synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0098793"(presynapse)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002441("Glucose transporter, type 4 (GLUT4)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-189200|ensembl:ENSRNOG00000017226(gene)|ensembl:ENSRNOT00000023256(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)	ensembl:ENSRNOG00000016807(gene)|ensembl:ENSRNOT00000022628(transcript)|go:"GO:0003992"("N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity")|go:"GO:0004587"(ornithine-oxo-acid transaminase activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0006591"(ornithine metabolic process)|go:"GO:0010121"(arginine catabolic process to proline via ornithine)|go:"GO:0019544"(arginine catabolic process to glutamate)|go:"GO:0030170"(pyridoxal phosphate binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0050155"("ornithine(lysine) transaminase activity")|go:"GO:0055129"(L-proline biosynthetic process)|interpro:IPR005814(Aminotransferase class-III)|interpro:IPR010164(Ornithine aminotransferase)|interpro:IPR015421(Pyridoxal phosphate-dependent transferase, major region, subdomain 1)|interpro:IPR015422(Pyridoxal phosphate-dependent transferase, major region, subdomain 2)|interpro:IPR015424(Pyridoxal phosphate-dependent transferase, major region)|reactome:R-RNO-8964539|rgd:621724|refseq:NP_071966.1	-	-	-	caution:"The participant EBI-349571(P68370) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919386(Q7TP47) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920972(Q5XIP9) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-916419(P11980) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919578(Q8R491) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920554(Q5U3Z7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920647(Q5U2X8) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920585(Q7TP24) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-779677(P05426) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-915744(P02454) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|agonist:Insulin was shown to increase or decrease GLUT4 protein interactions in specific cases.|comment:"Insulin decreased GLUT4 interactions with the following proteins: Q9ER30 (Sarcosin), P09527 (Rab-7), O88960 (N-ethylmaleimide sensitive), P09456 (PKA I regulatory subunit), P27881 (Hexokinase type II), P07872 (Acyl-coenzyme A oxidase), Q6DGF1 (Isocitrate dehydrogenase), Q9EQX9 (Ubiquitin-conjugating), Q63446 (Polyubiquitin), P24268 (Cathepsin D), Q91XW0 (Heat shock protein 86), Q5FVH0 (unknown), P58405 (Striatin 3), Q62667 (Major vault protein), Q66H50 (unknown), Q09167 (splicing factor), Q9JHU5 (Arfaptin 1)."|comment:"Insulin increased GLUT4 interaction with the following proteins:Q9Z1P2 (R-actinin-1), P45592 (Cofilin), Q9QXQ0 (R-actinin-4), P26473 (ADP-ribosylation factor), P26437 (ADP-ribosylation factor),   Q7TNP1 (Basigin 2), Q6P6R2 (Dihydrolipoamide dehydrogenase),   P04797 (GAPDH), Q63081 (Protein disulfide isomerase), P29457 (47 kDa heat shock protein), Q9R1J8 (Leprecan), O88638 (Putative eps protein),   Q64375 (Synaptonemal complex)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:NDPK - Interactions involving proteins containing InterPro domain IPR001564, Nucleoside diphosphate kinase, core.	taxid:10116(rat-l6)|taxid:10116(Rattus norvegicus)	-	2006/02/15	2021/11/30	rogid:PbFY2lfrty8yw40Jq7ShR7xfuV410116	rogid:STXZ1cVCNq+1Cj/AwVL35WpoHsE10116	intact-crc:44F3A2176D02515F|rigid:9RVm0UBcqQF4k06RGKO89Bg16Q8	false	myc tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P19357	uniprotkb:P62738	intact:EBI-915426|uniprotkb:P97900|ensembl:ENSRNOP00000023256	intact:EBI-915799|uniprotkb:P03996|uniprotkb:P04108|uniprotkb:P70476	psi-mi:glut4_rat(display_long)|uniprotkb:Glucose transporter type 4, insulin-responsive(gene name synonym)|uniprotkb:Slc2a4(gene name)|psi-mi:Slc2a4(display_short)|uniprotkb:Glut4(gene name synonym)	psi-mi:acta_rat(display_long)|uniprotkb:Alpha-actin-2(gene name synonym)|uniprotkb:Acta2(gene name)|psi-mi:Acta2(display_short)|uniprotkb:Actsa(gene name synonym)|uniprotkb:Actvs(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Foster et al. (2006)	pubmed:16396496|mint:MINT-5218203	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-921030	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2711|refseq:NP_036883.1|refseq:XP_006246658.1|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007611"(learning or memory)|go:"GO:0007614"(short-term memory)|go:"GO:0007616"(long-term memory)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010021"(amylopectin biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031550"(positive regulation of brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044381"(glucose import in response to insulin stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046323"(glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0098694"(regulation of synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0098793"(presynapse)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002441("Glucose transporter, type 4 (GLUT4)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-189200|ensembl:ENSRNOG00000017226(gene)|ensembl:ENSRNOT00000023256(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)	go:"GO:0005856"(cytoskeleton)|go:"GO:0005869"(dynactin complex)|go:"GO:0006936"(muscle contraction)|go:"GO:0008217"(regulation of blood pressure)|go:"GO:0009615"(response to virus)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0014829"(vascular associated smooth muscle contraction)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030027"(lamellipodium)|go:"GO:0030175"(filopodium)|go:"GO:0030485"(smooth muscle contractile fiber)|go:"GO:0032991"(protein-containing complex)|go:"GO:0044297"(cell body)|go:"GO:0061041"(regulation of wound healing)|go:"GO:0061870"(positive regulation of hepatic stellate cell migration)|go:"GO:0061874"(positive regulation of hepatic stellate cell contraction)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0072144"(glomerular mesangial cell development)|go:"GO:0090131"(mesenchyme migration)|go:"GO:2000491"(positive regulation of hepatic stellate cell activation)|go:"GO:0001725"(stress fiber)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|rgd:621676|refseq:NP_112266.1|interpro:IPR004000(Actin/actin-like)|interpro:IPR020902|interpro:IPR004001(Actin, conserved site)|interpro:IPR043129|reactome:R-RNO-445355	-	-	-	caution:"The participant EBI-349571(P68370) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919386(Q7TP47) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920972(Q5XIP9) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-916419(P11980) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919578(Q8R491) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920554(Q5U3Z7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920647(Q5U2X8) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920585(Q7TP24) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-779677(P05426) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-915744(P02454) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|agonist:Insulin was shown to increase or decrease GLUT4 protein interactions in specific cases.|comment:"Insulin decreased GLUT4 interactions with the following proteins: Q9ER30 (Sarcosin), P09527 (Rab-7), O88960 (N-ethylmaleimide sensitive), P09456 (PKA I regulatory subunit), P27881 (Hexokinase type II), P07872 (Acyl-coenzyme A oxidase), Q6DGF1 (Isocitrate dehydrogenase), Q9EQX9 (Ubiquitin-conjugating), Q63446 (Polyubiquitin), P24268 (Cathepsin D), Q91XW0 (Heat shock protein 86), Q5FVH0 (unknown), P58405 (Striatin 3), Q62667 (Major vault protein), Q66H50 (unknown), Q09167 (splicing factor), Q9JHU5 (Arfaptin 1)."|comment:"Insulin increased GLUT4 interaction with the following proteins:Q9Z1P2 (R-actinin-1), P45592 (Cofilin), Q9QXQ0 (R-actinin-4), P26473 (ADP-ribosylation factor), P26437 (ADP-ribosylation factor),   Q7TNP1 (Basigin 2), Q6P6R2 (Dihydrolipoamide dehydrogenase),   P04797 (GAPDH), Q63081 (Protein disulfide isomerase), P29457 (47 kDa heat shock protein), Q9R1J8 (Leprecan), O88638 (Putative eps protein),   Q64375 (Synaptonemal complex)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:NDPK - Interactions involving proteins containing InterPro domain IPR001564, Nucleoside diphosphate kinase, core.	taxid:10116(rat-l6)|taxid:10116(Rattus norvegicus)	-	2006/02/15	2021/11/30	rogid:PbFY2lfrty8yw40Jq7ShR7xfuV410116	rogid:mRZGUdL/jBuj6nVHtxoasZuA7yA10116	intact-crc:44F3A2176D02515F|rigid:9RVm0UBcqQF4k06RGKO89Bg16Q8	false	myc tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P19357	uniprotkb:P02600	intact:EBI-915426|uniprotkb:P97900|ensembl:ENSRNOP00000023256	intact:EBI-915764|ensembl:ENSRNOP00000017838|uniprotkb:P02601	psi-mi:glut4_rat(display_long)|uniprotkb:Glucose transporter type 4, insulin-responsive(gene name synonym)|uniprotkb:Slc2a4(gene name)|psi-mi:Slc2a4(display_short)|uniprotkb:Glut4(gene name synonym)	psi-mi:myl1_rat(display_long)|uniprotkb:Myosin light chain alkali 1/2(gene name synonym)|uniprotkb:Myl1(gene name)|psi-mi:Myl1(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Foster et al. (2006)	pubmed:16396496|mint:MINT-5218203	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-921030	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2711|refseq:NP_036883.1|refseq:XP_006246658.1|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007611"(learning or memory)|go:"GO:0007614"(short-term memory)|go:"GO:0007616"(long-term memory)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010021"(amylopectin biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031550"(positive regulation of brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044381"(glucose import in response to insulin stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046323"(glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0098694"(regulation of synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0098793"(presynapse)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002441("Glucose transporter, type 4 (GLUT4)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-189200|ensembl:ENSRNOG00000017226(gene)|ensembl:ENSRNOT00000023256(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)	ensembl:ENSRNOG00000013262(gene)|ensembl:ENSRNOT00000017838(transcript)|go:"GO:0005509"(calcium ion binding)|go:"GO:0006936"(muscle contraction)|go:"GO:0008307"(structural constituent of muscle)|go:"GO:0016459"(myosin complex)|go:"GO:0030016"(myofibril)|go:"GO:0043292"(contractile fiber)|go:"GO:0060048"(cardiac muscle contraction)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR011992(EF-Hand type)|mint:P02600|reactome:R-RNO-390522|rgd:1598796|refseq:NP_001071124.1|refseq:NP_064489.1	-	-	-	caution:"The participant EBI-349571(P68370) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919386(Q7TP47) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920972(Q5XIP9) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-916419(P11980) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919578(Q8R491) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920554(Q5U3Z7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920647(Q5U2X8) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920585(Q7TP24) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-779677(P05426) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-915744(P02454) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|agonist:Insulin was shown to increase or decrease GLUT4 protein interactions in specific cases.|comment:"Insulin decreased GLUT4 interactions with the following proteins: Q9ER30 (Sarcosin), P09527 (Rab-7), O88960 (N-ethylmaleimide sensitive), P09456 (PKA I regulatory subunit), P27881 (Hexokinase type II), P07872 (Acyl-coenzyme A oxidase), Q6DGF1 (Isocitrate dehydrogenase), Q9EQX9 (Ubiquitin-conjugating), Q63446 (Polyubiquitin), P24268 (Cathepsin D), Q91XW0 (Heat shock protein 86), Q5FVH0 (unknown), P58405 (Striatin 3), Q62667 (Major vault protein), Q66H50 (unknown), Q09167 (splicing factor), Q9JHU5 (Arfaptin 1)."|comment:"Insulin increased GLUT4 interaction with the following proteins:Q9Z1P2 (R-actinin-1), P45592 (Cofilin), Q9QXQ0 (R-actinin-4), P26473 (ADP-ribosylation factor), P26437 (ADP-ribosylation factor),   Q7TNP1 (Basigin 2), Q6P6R2 (Dihydrolipoamide dehydrogenase),   P04797 (GAPDH), Q63081 (Protein disulfide isomerase), P29457 (47 kDa heat shock protein), Q9R1J8 (Leprecan), O88638 (Putative eps protein),   Q64375 (Synaptonemal complex)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:NDPK - Interactions involving proteins containing InterPro domain IPR001564, Nucleoside diphosphate kinase, core.	taxid:10116(rat-l6)|taxid:10116(Rattus norvegicus)	-	2006/02/15	2021/11/30	rogid:PbFY2lfrty8yw40Jq7ShR7xfuV410116	rogid:Od8zPKeIcP9aXndQm+UvHjKubno10116	intact-crc:44F3A2176D02515F|rigid:9RVm0UBcqQF4k06RGKO89Bg16Q8	false	myc tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P19357	uniprotkb:P63259	intact:EBI-915426|uniprotkb:P97900|ensembl:ENSRNOP00000023256	intact:EBI-351310|uniprotkb:P02571|uniprotkb:P14104|uniprotkb:P99022|ensembl:ENSRNOP00000051859|ensembl:ENSRNOP00000072273	psi-mi:glut4_rat(display_long)|uniprotkb:Glucose transporter type 4, insulin-responsive(gene name synonym)|uniprotkb:Slc2a4(gene name)|psi-mi:Slc2a4(display_short)|uniprotkb:Glut4(gene name synonym)	psi-mi:actg_rat(display_long)|uniprotkb:Actg1(gene name)|psi-mi:Actg1(display_short)|uniprotkb:Actg(gene name synonym)|uniprotkb:Gamma-actin(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Foster et al. (2006)	pubmed:16396496|mint:MINT-5218203	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-921030	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2711|refseq:NP_036883.1|refseq:XP_006246658.1|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007611"(learning or memory)|go:"GO:0007614"(short-term memory)|go:"GO:0007616"(long-term memory)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010021"(amylopectin biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031550"(positive regulation of brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044381"(glucose import in response to insulin stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046323"(glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0098694"(regulation of synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0098793"(presynapse)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002441("Glucose transporter, type 4 (GLUT4)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-189200|ensembl:ENSRNOG00000017226(gene)|ensembl:ENSRNOT00000023256(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)	rgd:1304556|refseq:NP_001120921.1|ensembl:ENSRNOG00000036701(gene)|ensembl:ENSRNOG00000053452(gene)|ensembl:ENSRNOT00000054976(transcript)|ensembl:ENSRNOT00000079310(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001738"(morphogenesis of a polarized epithelium)|go:"GO:0005200"(structural constituent of cytoskeleton)|go:"GO:0005522"(profilin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005884"(actin filament)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005925"(focal adhesion)|go:"GO:0009612"(response to mechanical stimulus)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0030016"(myofibril)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031941"(filamentous actin)|go:"GO:0042802"(identical protein binding)|go:"GO:0043296"(apical junction complex)|go:"GO:0044305"(calyx of Held)|go:"GO:0045177"(apical part of cell)|go:"GO:0045214"(sarcomere organization)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0048488"(synaptic vesicle endocytosis)|go:"GO:0051492"(regulation of stress fiber assembly)|go:"GO:0051592"(response to calcium ion)|go:"GO:0051893"(regulation of focal adhesion assembly)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0090303"(positive regulation of wound healing)|go:"GO:0097433"(dense body)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098871"(postsynaptic actin cytoskeleton)|go:"GO:0098973"(structural constituent of postsynaptic actin cytoskeleton)|go:"GO:0099143"(presynaptic actin cytoskeleton)|go:"GO:0120192"(tight junction assembly)|go:"GO:0120220"(basal body patch)|go:"GO:0150111"(regulation of transepithelial transport)|go:"GO:1902396"(protein localization to bicellular tight junction)|interpro:IPR004000(Actin/actin-like)|interpro:IPR004001(Actin, conserved site)|interpro:IPR020902|interpro:IPR043129|reactome:R-RNO-114608|reactome:R-RNO-190873|reactome:R-RNO-196025|reactome:R-RNO-2029482|reactome:R-RNO-3928662|reactome:R-RNO-418990|reactome:R-RNO-437239|reactome:R-RNO-4420097|reactome:R-RNO-445095|reactome:R-RNO-446353|reactome:R-RNO-5626467|reactome:R-RNO-5663213|reactome:R-RNO-5663220|reactome:R-RNO-5674135|reactome:R-RNO-8856828|reactome:R-RNO-9013418|refseq:XP_002729242.3|refseq:XP_017452655.1	-	-	-	caution:"The participant EBI-349571(P68370) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919386(Q7TP47) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920972(Q5XIP9) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-916419(P11980) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919578(Q8R491) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920554(Q5U3Z7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920647(Q5U2X8) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920585(Q7TP24) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-779677(P05426) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-915744(P02454) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|agonist:Insulin was shown to increase or decrease GLUT4 protein interactions in specific cases.|comment:"Insulin decreased GLUT4 interactions with the following proteins: Q9ER30 (Sarcosin), P09527 (Rab-7), O88960 (N-ethylmaleimide sensitive), P09456 (PKA I regulatory subunit), P27881 (Hexokinase type II), P07872 (Acyl-coenzyme A oxidase), Q6DGF1 (Isocitrate dehydrogenase), Q9EQX9 (Ubiquitin-conjugating), Q63446 (Polyubiquitin), P24268 (Cathepsin D), Q91XW0 (Heat shock protein 86), Q5FVH0 (unknown), P58405 (Striatin 3), Q62667 (Major vault protein), Q66H50 (unknown), Q09167 (splicing factor), Q9JHU5 (Arfaptin 1)."|comment:"Insulin increased GLUT4 interaction with the following proteins:Q9Z1P2 (R-actinin-1), P45592 (Cofilin), Q9QXQ0 (R-actinin-4), P26473 (ADP-ribosylation factor), P26437 (ADP-ribosylation factor),   Q7TNP1 (Basigin 2), Q6P6R2 (Dihydrolipoamide dehydrogenase),   P04797 (GAPDH), Q63081 (Protein disulfide isomerase), P29457 (47 kDa heat shock protein), Q9R1J8 (Leprecan), O88638 (Putative eps protein),   Q64375 (Synaptonemal complex)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:NDPK - Interactions involving proteins containing InterPro domain IPR001564, Nucleoside diphosphate kinase, core.	taxid:10116(rat-l6)|taxid:10116(Rattus norvegicus)	-	2006/02/15	2021/11/30	rogid:PbFY2lfrty8yw40Jq7ShR7xfuV410116	rogid:B2OOsE06lTfo90H3g8tlmUJQ7cY10116	intact-crc:44F3A2176D02515F|rigid:9RVm0UBcqQF4k06RGKO89Bg16Q8	false	myc tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P19357	uniprotkb:P68136	intact:EBI-915426|uniprotkb:P97900|ensembl:ENSRNOP00000023256	intact:EBI-367530|uniprotkb:P02568|uniprotkb:P99020|ensembl:ENSRNOP00000024084	psi-mi:glut4_rat(display_long)|uniprotkb:Glucose transporter type 4, insulin-responsive(gene name synonym)|uniprotkb:Slc2a4(gene name)|psi-mi:Slc2a4(display_short)|uniprotkb:Glut4(gene name synonym)	psi-mi:acts_rat(display_long)|uniprotkb:Acta1(gene name)|psi-mi:Acta1(display_short)|uniprotkb:Acta(gene name synonym)|uniprotkb:Alpha-actin-1(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Foster et al. (2006)	pubmed:16396496|mint:MINT-5218203	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-921030	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2711|refseq:NP_036883.1|refseq:XP_006246658.1|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007611"(learning or memory)|go:"GO:0007614"(short-term memory)|go:"GO:0007616"(long-term memory)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010021"(amylopectin biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031550"(positive regulation of brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044381"(glucose import in response to insulin stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046323"(glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0098694"(regulation of synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0098793"(presynapse)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002441("Glucose transporter, type 4 (GLUT4)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-189200|ensembl:ENSRNOG00000017226(gene)|ensembl:ENSRNOT00000023256(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)	ensembl:ENSRNOG00000017786(gene)|ensembl:ENSRNOT00000024084(transcript)|go:"GO:0001725"(stress fiber)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005865"(striated muscle thin filament)|go:"GO:0005869"(dynactin complex)|go:"GO:0005884"(actin filament)|go:"GO:0009612"(response to mechanical stimulus)|go:"GO:0009991"(response to extracellular stimulus)|go:"GO:0010226"(response to lithium ion)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0030017"(sarcomere)|go:"GO:0030027"(lamellipodium)|go:"GO:0030175"(filopodium)|go:"GO:0030240"(skeletal muscle thin filament assembly)|go:"GO:0043503"(skeletal muscle fiber adaptation)|go:"GO:0044297"(cell body)|go:"GO:0048545"(response to steroid hormone)|go:"GO:0048741"(skeletal muscle fiber development)|go:"GO:0071417"(cellular response to organonitrogen compound)|go:"GO:0090131"(mesenchyme migration)|interpro:IPR004000(Actin/actin-like)|interpro:IPR004001(Actin, conserved site)|interpro:IPR020902|interpro:IPR043129|rcsb pdb:3U9D|reactome:R-RNO-390522|rgd:2025|refseq:NP_062085.1	-	-	-	caution:"The participant EBI-349571(P68370) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919386(Q7TP47) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920972(Q5XIP9) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-916419(P11980) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919578(Q8R491) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920554(Q5U3Z7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920647(Q5U2X8) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920585(Q7TP24) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-779677(P05426) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-915744(P02454) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|agonist:Insulin was shown to increase or decrease GLUT4 protein interactions in specific cases.|comment:"Insulin decreased GLUT4 interactions with the following proteins: Q9ER30 (Sarcosin), P09527 (Rab-7), O88960 (N-ethylmaleimide sensitive), P09456 (PKA I regulatory subunit), P27881 (Hexokinase type II), P07872 (Acyl-coenzyme A oxidase), Q6DGF1 (Isocitrate dehydrogenase), Q9EQX9 (Ubiquitin-conjugating), Q63446 (Polyubiquitin), P24268 (Cathepsin D), Q91XW0 (Heat shock protein 86), Q5FVH0 (unknown), P58405 (Striatin 3), Q62667 (Major vault protein), Q66H50 (unknown), Q09167 (splicing factor), Q9JHU5 (Arfaptin 1)."|comment:"Insulin increased GLUT4 interaction with the following proteins:Q9Z1P2 (R-actinin-1), P45592 (Cofilin), Q9QXQ0 (R-actinin-4), P26473 (ADP-ribosylation factor), P26437 (ADP-ribosylation factor),   Q7TNP1 (Basigin 2), Q6P6R2 (Dihydrolipoamide dehydrogenase),   P04797 (GAPDH), Q63081 (Protein disulfide isomerase), P29457 (47 kDa heat shock protein), Q9R1J8 (Leprecan), O88638 (Putative eps protein),   Q64375 (Synaptonemal complex)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:NDPK - Interactions involving proteins containing InterPro domain IPR001564, Nucleoside diphosphate kinase, core.	taxid:10116(rat-l6)|taxid:10116(Rattus norvegicus)	-	2006/02/15	2021/11/30	rogid:PbFY2lfrty8yw40Jq7ShR7xfuV410116	rogid:2vZu8ElmMe+6GjKBliCAatNGZR410116	intact-crc:44F3A2176D02515F|rigid:9RVm0UBcqQF4k06RGKO89Bg16Q8	false	myc tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P19357	uniprotkb:P02466	intact:EBI-915426|uniprotkb:P97900|ensembl:ENSRNOP00000023256	intact:EBI-915755|uniprotkb:Q9R1E8	psi-mi:glut4_rat(display_long)|uniprotkb:Glucose transporter type 4, insulin-responsive(gene name synonym)|uniprotkb:Slc2a4(gene name)|psi-mi:Slc2a4(display_short)|uniprotkb:Glut4(gene name synonym)	psi-mi:co1a2_rat(display_long)|uniprotkb:Alpha-2 type I collagen(gene name synonym)|uniprotkb:Col1a2(gene name)|psi-mi:Col1a2(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Foster et al. (2006)	pubmed:16396496|mint:MINT-5218203	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-921030	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2711|refseq:NP_036883.1|refseq:XP_006246658.1|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007611"(learning or memory)|go:"GO:0007614"(short-term memory)|go:"GO:0007616"(long-term memory)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010021"(amylopectin biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031550"(positive regulation of brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044381"(glucose import in response to insulin stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046323"(glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0098694"(regulation of synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0098793"(presynapse)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002441("Glucose transporter, type 4 (GLUT4)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-189200|ensembl:ENSRNOG00000017226(gene)|ensembl:ENSRNOT00000023256(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)	rgd:621351|refseq:NP_445808.1|go:"GO:0001501"(skeletal system development)|go:"GO:0001568"(blood vessel development)|go:"GO:0002020"(protease binding)|go:"GO:0005201"(extracellular matrix structural constituent)|go:"GO:0005576"(extracellular region)|go:"GO:0005581"(collagen trimer)|go:"GO:0005584"(collagen type I trimer)|go:"GO:0005615"(extracellular space)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007266"(Rho protein signal transduction)|go:"GO:0008217"(regulation of blood pressure)|go:"GO:0030198"(extracellular matrix organization)|go:"GO:0030199"(collagen fibril organization)|go:"GO:0030282"(bone mineralization)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0031012"(extracellular matrix)|go:"GO:0032963"(collagen metabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0043589"(skin morphogenesis)|go:"GO:0046332"(SMAD binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0048407"(platelet-derived growth factor binding)|go:"GO:0070208"(protein heterotrimerization)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071300"(cellular response to retinoic acid)|go:"GO:0071310"(cellular response to organic substance)|go:"GO:0071873"(response to norepinephrine)|go:"GO:0085029"(extracellular matrix assembly)|go:"GO:0097067"(cellular response to thyroid hormone stimulus)|interpro:IPR000885(Fibrillar collagen, C-terminal)|interpro:IPR008160(Collagen triple helix repeat)|rcsb pdb:3HQV|rcsb pdb:3HR2|dip:DIP-37338N|reactome:R-RNO-114604|reactome:R-RNO-1442490|reactome:R-RNO-1474244|reactome:R-RNO-1650814|reactome:R-RNO-198933|reactome:R-RNO-2022090|reactome:R-RNO-202733|reactome:R-RNO-216083|reactome:R-RNO-2243919|reactome:R-RNO-3000171|reactome:R-RNO-3000178|reactome:R-RNO-430116|reactome:R-RNO-75892|reactome:R-RNO-76009|reactome:R-RNO-8874081|reactome:R-RNO-8948216	-	-	-	caution:"The participant EBI-349571(P68370) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919386(Q7TP47) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920972(Q5XIP9) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-916419(P11980) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919578(Q8R491) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920554(Q5U3Z7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920647(Q5U2X8) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920585(Q7TP24) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-779677(P05426) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-915744(P02454) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|agonist:Insulin was shown to increase or decrease GLUT4 protein interactions in specific cases.|comment:"Insulin decreased GLUT4 interactions with the following proteins: Q9ER30 (Sarcosin), P09527 (Rab-7), O88960 (N-ethylmaleimide sensitive), P09456 (PKA I regulatory subunit), P27881 (Hexokinase type II), P07872 (Acyl-coenzyme A oxidase), Q6DGF1 (Isocitrate dehydrogenase), Q9EQX9 (Ubiquitin-conjugating), Q63446 (Polyubiquitin), P24268 (Cathepsin D), Q91XW0 (Heat shock protein 86), Q5FVH0 (unknown), P58405 (Striatin 3), Q62667 (Major vault protein), Q66H50 (unknown), Q09167 (splicing factor), Q9JHU5 (Arfaptin 1)."|comment:"Insulin increased GLUT4 interaction with the following proteins:Q9Z1P2 (R-actinin-1), P45592 (Cofilin), Q9QXQ0 (R-actinin-4), P26473 (ADP-ribosylation factor), P26437 (ADP-ribosylation factor),   Q7TNP1 (Basigin 2), Q6P6R2 (Dihydrolipoamide dehydrogenase),   P04797 (GAPDH), Q63081 (Protein disulfide isomerase), P29457 (47 kDa heat shock protein), Q9R1J8 (Leprecan), O88638 (Putative eps protein),   Q64375 (Synaptonemal complex)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:NDPK - Interactions involving proteins containing InterPro domain IPR001564, Nucleoside diphosphate kinase, core.	taxid:10116(rat-l6)|taxid:10116(Rattus norvegicus)	-	2006/02/15	2021/11/30	rogid:PbFY2lfrty8yw40Jq7ShR7xfuV410116	rogid:vjeZcxrYMvVebQ03cRvi+rMKFSc10116	intact-crc:44F3A2176D02515F|rigid:9RVm0UBcqQF4k06RGKO89Bg16Q8	false	myc tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P19357	uniprotkb:P01346	intact:EBI-915426|uniprotkb:P97900|ensembl:ENSRNOP00000023256	intact:EBI-915736|ensembl:ENSRNOP00000047037|ensembl:ENSRNOP00000066983|ensembl:ENSRNOP00000070557	psi-mi:glut4_rat(display_long)|uniprotkb:Glucose transporter type 4, insulin-responsive(gene name synonym)|uniprotkb:Slc2a4(gene name)|psi-mi:Slc2a4(display_short)|uniprotkb:Glut4(gene name synonym)	psi-mi:igf2_rat(display_long)|uniprotkb:Multiplication-stimulating polypeptide(gene name synonym)|uniprotkb:Multiplication-stimulating activity(gene name synonym)|uniprotkb:Igf2(gene name)|psi-mi:Igf2(display_short)|uniprotkb:Igf-2(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Foster et al. (2006)	pubmed:16396496|mint:MINT-5218203	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-921030	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2711|refseq:NP_036883.1|refseq:XP_006246658.1|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007611"(learning or memory)|go:"GO:0007614"(short-term memory)|go:"GO:0007616"(long-term memory)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010021"(amylopectin biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031550"(positive regulation of brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044381"(glucose import in response to insulin stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046323"(glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0098694"(regulation of synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0098793"(presynapse)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002441("Glucose transporter, type 4 (GLUT4)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-189200|ensembl:ENSRNOG00000017226(gene)|ensembl:ENSRNOT00000023256(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)	rgd:2870|refseq:NP_001177091.1|refseq:NP_001177092.1|refseq:NP_113699.2|refseq:XP_006230727.1|ensembl:ENSRNOG00000020369(gene)|ensembl:ENSRNOT00000050760(transcript)|ensembl:ENSRNOT00000073850(transcript)|ensembl:ENSRNOT00000089171(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001892"(embryonic placenta development)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0005158"(insulin receptor binding)|go:"GO:0005159"(insulin-like growth factor receptor binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005179"(hormone activity)|go:"GO:0005615"(extracellular space)|go:"GO:0006006"(glucose metabolic process)|go:"GO:0007565"(female pregnancy)|go:"GO:0007613"(memory)|go:"GO:0008083"(growth factor activity)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009314"(response to radiation)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0014070"(response to organic cyclic compound)|go:"GO:0031017"(exocrine pancreas development)|go:"GO:0031056"(regulation of histone modification)|go:"GO:0031667"(response to nutrient levels)|go:"GO:0032355"(response to estradiol)|go:"GO:0035094"(response to nicotine)|go:"GO:0038028"(insulin receptor signaling pathway via phosphatidylinositol 3-kinase)|go:"GO:0040018"(positive regulation of multicellular organism growth)|go:"GO:0042060"(wound healing)|go:"GO:0042104"(positive regulation of activated T cell proliferation)|go:"GO:0042493"|go:"GO:0043085"(positive regulation of catalytic activity)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0043536"(positive regulation of blood vessel endothelial cell migration)|go:"GO:0043539"(protein serine/threonine kinase activator activity)|go:"GO:0045471"(response to ethanol)|go:"GO:0045725"(positive regulation of glycogen biosynthetic process)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0045840"(positive regulation of mitotic nuclear division)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0045953"(negative regulation of natural killer cell mediated cytotoxicity)|go:"GO:0046622"(positive regulation of organ growth)|go:"GO:0046628"(positive regulation of insulin receptor signaling pathway)|go:"GO:0048018"(receptor ligand activity)|go:"GO:0048633"(positive regulation of skeletal muscle tissue growth)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0051146"(striated muscle cell differentiation)|go:"GO:0051147"(regulation of muscle cell differentiation)|go:"GO:0051148"(negative regulation of muscle cell differentiation)|go:"GO:0051781"(positive regulation of cell division)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0060669"(embryonic placenta morphogenesis)|go:"GO:0060720"(spongiotrophoblast cell proliferation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0090031"(positive regulation of steroid hormone biosynthetic process)|go:"GO:1905564"(positive regulation of vascular endothelial cell proliferation)|go:"GO:2000467"("positive regulation of glycogen (starch) synthase activity")|interpro:IPR013576(Insulin-like growth factor II E-peptide, C-terminal)|interpro:IPR016179(Insulin-like)|interpro:IPR022334|interpro:IPR022350|interpro:IPR022352|interpro:IPR022353|interpro:IPR036438|reactome:R-RNO-114608|reactome:R-RNO-2404192|reactome:R-RNO-2428928|reactome:R-RNO-2428933|reactome:R-RNO-381426	-	-	-	caution:"The participant EBI-349571(P68370) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919386(Q7TP47) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920972(Q5XIP9) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-916419(P11980) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919578(Q8R491) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920554(Q5U3Z7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920647(Q5U2X8) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920585(Q7TP24) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-779677(P05426) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-915744(P02454) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|agonist:Insulin was shown to increase or decrease GLUT4 protein interactions in specific cases.|comment:"Insulin decreased GLUT4 interactions with the following proteins: Q9ER30 (Sarcosin), P09527 (Rab-7), O88960 (N-ethylmaleimide sensitive), P09456 (PKA I regulatory subunit), P27881 (Hexokinase type II), P07872 (Acyl-coenzyme A oxidase), Q6DGF1 (Isocitrate dehydrogenase), Q9EQX9 (Ubiquitin-conjugating), Q63446 (Polyubiquitin), P24268 (Cathepsin D), Q91XW0 (Heat shock protein 86), Q5FVH0 (unknown), P58405 (Striatin 3), Q62667 (Major vault protein), Q66H50 (unknown), Q09167 (splicing factor), Q9JHU5 (Arfaptin 1)."|comment:"Insulin increased GLUT4 interaction with the following proteins:Q9Z1P2 (R-actinin-1), P45592 (Cofilin), Q9QXQ0 (R-actinin-4), P26473 (ADP-ribosylation factor), P26437 (ADP-ribosylation factor),   Q7TNP1 (Basigin 2), Q6P6R2 (Dihydrolipoamide dehydrogenase),   P04797 (GAPDH), Q63081 (Protein disulfide isomerase), P29457 (47 kDa heat shock protein), Q9R1J8 (Leprecan), O88638 (Putative eps protein),   Q64375 (Synaptonemal complex)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:NDPK - Interactions involving proteins containing InterPro domain IPR001564, Nucleoside diphosphate kinase, core.	taxid:10116(rat-l6)|taxid:10116(Rattus norvegicus)	-	2006/02/15	2021/11/30	rogid:PbFY2lfrty8yw40Jq7ShR7xfuV410116	rogid:m+nDc24GFpIm46IeY3kgVjbNFo410116	intact-crc:44F3A2176D02515F|rigid:9RVm0UBcqQF4k06RGKO89Bg16Q8	false	myc tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P19357	uniprotkb:P00507	intact:EBI-915426|uniprotkb:P97900|ensembl:ENSRNOP00000023256	intact:EBI-915723|uniprotkb:Q64551|uniprotkb:Q9QV50|ensembl:ENSRNOP00000015956	psi-mi:glut4_rat(display_long)|uniprotkb:Glucose transporter type 4, insulin-responsive(gene name synonym)|uniprotkb:Slc2a4(gene name)|psi-mi:Slc2a4(display_short)|uniprotkb:Glut4(gene name synonym)	psi-mi:aatm_rat(display_long)|uniprotkb:Plasma membrane-associated fatty acid-binding protein(gene name synonym)|uniprotkb:Transaminase A(gene name synonym)|uniprotkb:Glutamate oxaloacetate transaminase 2(gene name synonym)|uniprotkb:Fatty acid-binding protein(gene name synonym)|uniprotkb:Got2(gene name)|psi-mi:Got2(display_short)|uniprotkb:Maat(gene name synonym)|uniprotkb:Kynurenine aminotransferase 4(gene name synonym)|uniprotkb:Kynurenine aminotransferase IV(gene name synonym)|uniprotkb:Kynurenine--oxoglutarate transaminase 4(gene name synonym)|uniprotkb:Kynurenine--oxoglutarate transaminase IV(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Foster et al. (2006)	pubmed:16396496|mint:MINT-5218203	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-921030	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2711|refseq:NP_036883.1|refseq:XP_006246658.1|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007611"(learning or memory)|go:"GO:0007614"(short-term memory)|go:"GO:0007616"(long-term memory)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010021"(amylopectin biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031550"(positive regulation of brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044381"(glucose import in response to insulin stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046323"(glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0098694"(regulation of synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0098793"(presynapse)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002441("Glucose transporter, type 4 (GLUT4)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-189200|ensembl:ENSRNOG00000017226(gene)|ensembl:ENSRNOT00000023256(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)	rgd:2722|refseq:NP_037309.1|reactome:R-RNO-70263|reactome:R-RNO-8963693|reactome:R-RNO-8964539|ensembl:ENSRNOG00000011782(gene)|ensembl:ENSRNOT00000015956(transcript)|go:"GO:0004069"("L-aspartate:2-oxoglutarate aminotransferase activity")|go:"GO:0005543"(phospholipid binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005886"(plasma membrane)|go:"GO:0006103"(2-oxoglutarate metabolic process)|go:"GO:0006107"(oxaloacetate metabolic process)|go:"GO:0006520"(cellular amino acid metabolic process)|go:"GO:0006531"(aspartate metabolic process)|go:"GO:0006532"(aspartate biosynthetic process)|go:"GO:0006533"(aspartate catabolic process)|go:"GO:0006536"(glutamate metabolic process)|go:"GO:0007565"(female pregnancy)|go:"GO:0007595"(lactation)|go:"GO:0009986"(cell surface)|go:"GO:0014850"(response to muscle activity)|go:"GO:0015908"(fatty acid transport)|go:"GO:0016212"(kynurenine-oxoglutarate transaminase activity)|go:"GO:0016597"(amino acid binding)|go:"GO:0019550"(glutamate catabolic process to aspartate)|go:"GO:0019551"(glutamate catabolic process to 2-oxoglutarate)|go:"GO:0019899"(enzyme binding)|go:"GO:0030170"(pyridoxal phosphate binding)|go:"GO:0030315"(T-tubule)|go:"GO:0031406"(carboxylic acid binding)|go:"GO:0032868"(response to insulin)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042383"(sarcolemma)|go:"GO:0042802"(identical protein binding)|go:"GO:0043204"(perikaryon)|go:"GO:0043278"(response to morphine)|go:"GO:0043648"(dicarboxylic acid metabolic process)|go:"GO:0045471"(response to ethanol)|interpro:IPR000796(Aspartate/other aminotransferase)|interpro:IPR004838(Aminotransferases, class-I, pyridoxal-phosphate-binding site)|interpro:IPR004839(Aminotransferase, class I and II)|interpro:IPR015421(Pyridoxal phosphate-dependent transferase, major region, subdomain 1)|interpro:IPR015422(Pyridoxal phosphate-dependent transferase, major region, subdomain 2)|interpro:IPR015424(Pyridoxal phosphate-dependent transferase, major region)|mint:P00507|reactome:R-RNO-389661	-	-	-	caution:"The participant EBI-349571(P68370) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919386(Q7TP47) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920972(Q5XIP9) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-916419(P11980) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919578(Q8R491) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920554(Q5U3Z7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920647(Q5U2X8) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920585(Q7TP24) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-779677(P05426) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-915744(P02454) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|agonist:Insulin was shown to increase or decrease GLUT4 protein interactions in specific cases.|comment:"Insulin decreased GLUT4 interactions with the following proteins: Q9ER30 (Sarcosin), P09527 (Rab-7), O88960 (N-ethylmaleimide sensitive), P09456 (PKA I regulatory subunit), P27881 (Hexokinase type II), P07872 (Acyl-coenzyme A oxidase), Q6DGF1 (Isocitrate dehydrogenase), Q9EQX9 (Ubiquitin-conjugating), Q63446 (Polyubiquitin), P24268 (Cathepsin D), Q91XW0 (Heat shock protein 86), Q5FVH0 (unknown), P58405 (Striatin 3), Q62667 (Major vault protein), Q66H50 (unknown), Q09167 (splicing factor), Q9JHU5 (Arfaptin 1)."|comment:"Insulin increased GLUT4 interaction with the following proteins:Q9Z1P2 (R-actinin-1), P45592 (Cofilin), Q9QXQ0 (R-actinin-4), P26473 (ADP-ribosylation factor), P26437 (ADP-ribosylation factor),   Q7TNP1 (Basigin 2), Q6P6R2 (Dihydrolipoamide dehydrogenase),   P04797 (GAPDH), Q63081 (Protein disulfide isomerase), P29457 (47 kDa heat shock protein), Q9R1J8 (Leprecan), O88638 (Putative eps protein),   Q64375 (Synaptonemal complex)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:NDPK - Interactions involving proteins containing InterPro domain IPR001564, Nucleoside diphosphate kinase, core.	taxid:10116(rat-l6)|taxid:10116(Rattus norvegicus)	-	2006/02/15	2021/11/30	rogid:PbFY2lfrty8yw40Jq7ShR7xfuV410116	rogid:DmuLdUQ/Ak7zSKqE7Viztf5O1CM10116	intact-crc:44F3A2176D02515F|rigid:9RVm0UBcqQF4k06RGKO89Bg16Q8	false	myc tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P19357	uniprotkb:O88960	intact:EBI-915426|uniprotkb:P97900|ensembl:ENSRNOP00000023256	intact:EBI-915717	psi-mi:glut4_rat(display_long)|uniprotkb:Glucose transporter type 4, insulin-responsive(gene name synonym)|uniprotkb:Slc2a4(gene name)|psi-mi:Slc2a4(display_short)|uniprotkb:Glut4(gene name synonym)	psi-mi:o88960_rat(display_long)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Foster et al. (2006)	pubmed:16396496|mint:MINT-5218203	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-921030	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2711|refseq:NP_036883.1|refseq:XP_006246658.1|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007611"(learning or memory)|go:"GO:0007614"(short-term memory)|go:"GO:0007616"(long-term memory)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010021"(amylopectin biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031550"(positive regulation of brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044381"(glucose import in response to insulin stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046323"(glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0098694"(regulation of synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0098793"(presynapse)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002441("Glucose transporter, type 4 (GLUT4)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-189200|ensembl:ENSRNOG00000017226(gene)|ensembl:ENSRNOT00000023256(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)	interpro:IPR004201(Cell division protein 48, CDC48, domain 2)|interpro:IPR029067|interpro:IPR039812|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0015031"(protein transport)|go:"GO:0035494"(SNARE complex disassembly)|go:"GO:0046872"(metal ion binding)|go:"GO:0140603"(obsolete ATP hydrolysis activity)	-	-	-	caution:"The participant EBI-349571(P68370) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919386(Q7TP47) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920972(Q5XIP9) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-916419(P11980) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919578(Q8R491) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920554(Q5U3Z7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920647(Q5U2X8) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920585(Q7TP24) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-779677(P05426) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-915744(P02454) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|agonist:Insulin was shown to increase or decrease GLUT4 protein interactions in specific cases.|comment:"Insulin decreased GLUT4 interactions with the following proteins: Q9ER30 (Sarcosin), P09527 (Rab-7), O88960 (N-ethylmaleimide sensitive), P09456 (PKA I regulatory subunit), P27881 (Hexokinase type II), P07872 (Acyl-coenzyme A oxidase), Q6DGF1 (Isocitrate dehydrogenase), Q9EQX9 (Ubiquitin-conjugating), Q63446 (Polyubiquitin), P24268 (Cathepsin D), Q91XW0 (Heat shock protein 86), Q5FVH0 (unknown), P58405 (Striatin 3), Q62667 (Major vault protein), Q66H50 (unknown), Q09167 (splicing factor), Q9JHU5 (Arfaptin 1)."|comment:"Insulin increased GLUT4 interaction with the following proteins:Q9Z1P2 (R-actinin-1), P45592 (Cofilin), Q9QXQ0 (R-actinin-4), P26473 (ADP-ribosylation factor), P26437 (ADP-ribosylation factor),   Q7TNP1 (Basigin 2), Q6P6R2 (Dihydrolipoamide dehydrogenase),   P04797 (GAPDH), Q63081 (Protein disulfide isomerase), P29457 (47 kDa heat shock protein), Q9R1J8 (Leprecan), O88638 (Putative eps protein),   Q64375 (Synaptonemal complex)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:NDPK - Interactions involving proteins containing InterPro domain IPR001564, Nucleoside diphosphate kinase, core.	taxid:10116(rat-l6)|taxid:10116(Rattus norvegicus)	-	2006/02/15	2021/11/30	rogid:PbFY2lfrty8yw40Jq7ShR7xfuV410116	rogid:SUeuKu2lW45af2zU+9Gk8LgmgR810116	intact-crc:44F3A2176D02515F|rigid:9RVm0UBcqQF4k06RGKO89Bg16Q8	false	myc tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P19357	uniprotkb:O88941	intact:EBI-915426|uniprotkb:P97900|ensembl:ENSRNOP00000023256	intact:EBI-915711	psi-mi:glut4_rat(display_long)|uniprotkb:Glucose transporter type 4, insulin-responsive(gene name synonym)|uniprotkb:Slc2a4(gene name)|psi-mi:Slc2a4(display_short)|uniprotkb:Glut4(gene name synonym)	psi-mi:mogs_rat(display_long)|uniprotkb:Glycoprotein-processing glucosidase I(gene name synonym)|uniprotkb:Mogs(gene name)|psi-mi:Mogs(display_short)|uniprotkb:Gcs1(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Foster et al. (2006)	pubmed:16396496|mint:MINT-5218203	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-921030	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2711|refseq:NP_036883.1|refseq:XP_006246658.1|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007611"(learning or memory)|go:"GO:0007614"(short-term memory)|go:"GO:0007616"(long-term memory)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010021"(amylopectin biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031550"(positive regulation of brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044381"(glucose import in response to insulin stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046323"(glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0098694"(regulation of synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0098793"(presynapse)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002441("Glucose transporter, type 4 (GLUT4)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-189200|ensembl:ENSRNOG00000017226(gene)|ensembl:ENSRNOT00000023256(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)	rgd:69240|refseq:NP_113937.1|interpro:IPR008928(Six-hairpin glycosidase-like)|interpro:IPR004888(Glycoside hydrolase, family 63)|interpro:IPR031335|interpro:IPR031631|interpro:IPR012341(Six-hairpin glycosidase)|interpro:IPR038518|go:"GO:0004573"(Glc3Man9GlcNAc2 oligosaccharide glucosidase activity)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0006487"(protein N-linked glycosylation)|go:"GO:0009311"(oligosaccharide metabolic process)|go:"GO:0016021"(integral component of membrane)	-	-	-	caution:"The participant EBI-349571(P68370) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919386(Q7TP47) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920972(Q5XIP9) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-916419(P11980) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919578(Q8R491) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920554(Q5U3Z7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920647(Q5U2X8) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920585(Q7TP24) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-779677(P05426) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-915744(P02454) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|agonist:Insulin was shown to increase or decrease GLUT4 protein interactions in specific cases.|comment:"Insulin decreased GLUT4 interactions with the following proteins: Q9ER30 (Sarcosin), P09527 (Rab-7), O88960 (N-ethylmaleimide sensitive), P09456 (PKA I regulatory subunit), P27881 (Hexokinase type II), P07872 (Acyl-coenzyme A oxidase), Q6DGF1 (Isocitrate dehydrogenase), Q9EQX9 (Ubiquitin-conjugating), Q63446 (Polyubiquitin), P24268 (Cathepsin D), Q91XW0 (Heat shock protein 86), Q5FVH0 (unknown), P58405 (Striatin 3), Q62667 (Major vault protein), Q66H50 (unknown), Q09167 (splicing factor), Q9JHU5 (Arfaptin 1)."|comment:"Insulin increased GLUT4 interaction with the following proteins:Q9Z1P2 (R-actinin-1), P45592 (Cofilin), Q9QXQ0 (R-actinin-4), P26473 (ADP-ribosylation factor), P26437 (ADP-ribosylation factor),   Q7TNP1 (Basigin 2), Q6P6R2 (Dihydrolipoamide dehydrogenase),   P04797 (GAPDH), Q63081 (Protein disulfide isomerase), P29457 (47 kDa heat shock protein), Q9R1J8 (Leprecan), O88638 (Putative eps protein),   Q64375 (Synaptonemal complex)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:NDPK - Interactions involving proteins containing InterPro domain IPR001564, Nucleoside diphosphate kinase, core.	taxid:10116(rat-l6)|taxid:10116(Rattus norvegicus)	-	2006/02/15	2021/11/30	rogid:PbFY2lfrty8yw40Jq7ShR7xfuV410116	rogid:YybFuGHco5MOJhxsIXa0QExwMbY10116	intact-crc:44F3A2176D02515F|rigid:9RVm0UBcqQF4k06RGKO89Bg16Q8	false	myc tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P19357	uniprotkb:O88767	intact:EBI-915426|uniprotkb:P97900|ensembl:ENSRNOP00000023256	intact:EBI-915704|ensembl:ENSRNOP00000024711|ensembl:ENSRNOP00000072068	psi-mi:glut4_rat(display_long)|uniprotkb:Glucose transporter type 4, insulin-responsive(gene name synonym)|uniprotkb:Slc2a4(gene name)|psi-mi:Slc2a4(display_short)|uniprotkb:Glut4(gene name synonym)	psi-mi:park7_rat(display_long)|uniprotkb:Contraception-associated protein 1(gene name synonym)|uniprotkb:Fertility protein SP22(gene name synonym)|uniprotkb:Maillard deglycase(gene name synonym)|uniprotkb:Parkinsonism-associated deglycase(gene name synonym)|uniprotkb:Protein DJ-1(gene name synonym)|uniprotkb:Protein/nucleic acid deglycase DJ-1(gene name synonym)|uniprotkb:Park7(gene name)|psi-mi:Park7(display_short)|uniprotkb:Cap1(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Foster et al. (2006)	pubmed:16396496|mint:MINT-5218203	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-921030	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2711|refseq:NP_036883.1|refseq:XP_006246658.1|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007611"(learning or memory)|go:"GO:0007614"(short-term memory)|go:"GO:0007616"(long-term memory)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010021"(amylopectin biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031550"(positive regulation of brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044381"(glucose import in response to insulin stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046323"(glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0098694"(regulation of synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0098793"(presynapse)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002441("Glucose transporter, type 4 (GLUT4)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-189200|ensembl:ENSRNOG00000017226(gene)|ensembl:ENSRNOT00000023256(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)	rgd:621808|refseq:NP_476484.1|ensembl:ENSRNOG00000018289(gene)|ensembl:ENSRNOT00000024711(transcript)|ensembl:ENSRNOT00000087402(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0001963"(synaptic transmission, dopaminergic)|go:"GO:0002866"(positive regulation of acute inflammatory response to antigenic stimulus)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0003729"(mRNA binding)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005507"(copper ion binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006281"(DNA repair)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0006517"(protein deglycosylation)|go:"GO:0006914"(autophagy)|go:"GO:0006954"(inflammatory response)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007338"(single fertilization)|go:"GO:0007568"(aging)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008233"(peptidase activity)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0009438"(methylglyoxal metabolic process)|go:"GO:0009566"(fertilization)|go:"GO:0010273"(detoxification of copper ion)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0016532"(superoxide dismutase copper chaperone activity)|go:"GO:0016570"(histone modification)|go:"GO:0016605"(PML body)|go:"GO:0016684"(oxidoreductase activity, acting on peroxide as acceptor)|go:"GO:0019249"(lactate biosynthetic process)|go:"GO:0019826"(oxygen sensor activity)|go:"GO:0019899"(enzyme binding)|go:"GO:0019900"(kinase binding)|go:"GO:0019955"(cytokine binding)|go:"GO:0030073"(insulin secretion)|refseq:NP_001264179.1|refseq:NP_001264180.1|refseq:NP_001264181.1|refseq:NP_001264182.1|go:"GO:0030424"(axon)|go:"GO:0031334"(positive regulation of protein-containing complex assembly)|go:"GO:0031397"(negative regulation of protein ubiquitination)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032435"(negative regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0033182"(regulation of histone ubiquitination)|go:"GO:0033234"(negative regulation of protein sumoylation)|go:"GO:0033864"("positive regulation of NAD(P)H oxidase activity")|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0034614"(cellular response to reactive oxygen species)|go:"GO:0035065"(regulation of histone acetylation)|go:"GO:0036470"(tyrosine 3-monooxygenase activator activity)|go:"GO:0036471"(cellular response to glyoxal)|go:"GO:0036478"(L-dopa decarboxylase activator activity)|go:"GO:0036524"(protein deglycase activity)|go:"GO:0036526"(peptidyl-cysteine deglycation)|go:"GO:0036527"(peptidyl-arginine deglycation)|go:"GO:0036528"(peptidyl-lysine deglycation)|go:"GO:0036529"(protein deglycation, glyoxal removal)|go:"GO:0036530"(protein deglycation, methylglyoxal removal)|go:"GO:0036531"(glutathione deglycation)|go:"GO:0042177"(negative regulation of protein catabolic process)|go:"GO:0042493"|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042743"(hydrogen peroxide metabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043005"(neuron projection)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043523"(regulation of neuron apoptotic process)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0044297"(cell body)|go:"GO:0044388"(small protein activating enzyme binding)|go:"GO:0044390"(ubiquitin-like protein conjugating enzyme binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045121"(membrane raft)|go:"GO:0045340"(mercury ion binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046295"(glycolate biosynthetic process)|go:"GO:0046826"(negative regulation of protein export from nucleus)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050681"(androgen receptor binding)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0050787"(detoxification of mercury ion)|go:"GO:0050821"(protein stabilization)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051444"(negative regulation of ubiquitin-protein transferase activity)|go:"GO:0051583"(dopamine uptake involved in synaptic transmission)|go:"GO:0051881"(regulation of mitochondrial membrane potential)|go:"GO:0051899"(membrane depolarization)|go:"GO:0051920"(peroxiredoxin activity)|go:"GO:0060081"(membrane hyperpolarization)|go:"GO:0060135"(maternal process involved in female pregnancy)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0060765"(regulation of androgen receptor signaling pathway)|go:"GO:0061727"(methylglyoxal catabolic process to lactate)|go:"GO:0061827"(sperm head)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0070994"(detection of oxidative stress)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0098793"(presynapse)|go:"GO:0106044"(guanine deglycation)|go:"GO:0106045"(guanine deglycation, methylglyoxal removal)|go:"GO:0106046"(guanine deglycation, glyoxal removal)|go:"GO:0110095"(cellular detoxification of aldehyde)|go:"GO:0140041"(cellular detoxification of methylglyoxal)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1900182"(positive regulation of protein localization to nucleus)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1901671"(positive regulation of superoxide dismutase activity)|go:"GO:1901984"(negative regulation of protein acetylation)|go:"GO:1902177"(positive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway)|go:"GO:1902236"(negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway)|go:"GO:1902958"(positive regulation of mitochondrial electron transport, NADH to ubiquinone)|go:"GO:1903094"(negative regulation of protein K48-linked deubiquitination)|go:"GO:1903122"(negative regulation of TRAIL-activated apoptotic signaling pathway)|go:"GO:1903135"(cupric ion binding)|go:"GO:1903136"(cuprous ion binding)|go:"GO:1903168"(positive regulation of pyrroline-5-carboxylate reductase activity)|go:"GO:1903178"(positive regulation of tyrosine 3-monooxygenase activity)|go:"GO:1903181"(positive regulation of dopamine biosynthetic process)|go:"GO:1903189"(glyoxal metabolic process)|go:"GO:1903197"(positive regulation of L-dopa biosynthetic process)|go:"GO:1903200"(positive regulation of L-dopa decarboxylase activity)|go:"GO:1903202"(negative regulation of oxidative stress-induced cell death)|go:"GO:1903204"(negative regulation of oxidative stress-induced neuron death)|go:"GO:1903206"(negative regulation of hydrogen peroxide-induced cell death)|go:"GO:1903208"(negative regulation of hydrogen peroxide-induced neuron death)|go:"GO:1903377"(negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway)|go:"GO:1903384"(negative regulation of hydrogen peroxide-induced neuron intrinsic apoptotic signaling pathway)|go:"GO:1903427"(negative regulation of reactive oxygen species biosynthetic process)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1904782"(negative regulation of NMDA glutamate receptor activity)|go:"GO:1905259"(negative regulation of nitrosative stress-induced intrinsic apoptotic signaling pathway)|go:"GO:1905516"(positive regulation of fertilization)|go:"GO:1990381"(ubiquitin-specific protease binding)|go:"GO:1990422"("glyoxalase (glycolic acid-forming) activity")|go:"GO:2000157"(negative regulation of ubiquitin-specific protease activity)|go:"GO:2000277"(positive regulation of oxidative phosphorylation uncoupler activity)|go:"GO:2000679"(positive regulation of transcription regulatory region DNA binding)|go:"GO:2000825"(positive regulation of androgen receptor activity)|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway)|go:"GO:2001268"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway)|interpro:IPR002818(ThiJ/PfpI)|interpro:IPR006287(DJ-1)|interpro:IPR029062|mint:O88767|reactome:R-RNO-3899300|reactome:R-RNO-9646399	-	-	-	caution:"The participant EBI-349571(P68370) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919386(Q7TP47) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920972(Q5XIP9) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-916419(P11980) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919578(Q8R491) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920554(Q5U3Z7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920647(Q5U2X8) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920585(Q7TP24) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-779677(P05426) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-915744(P02454) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|agonist:Insulin was shown to increase or decrease GLUT4 protein interactions in specific cases.|comment:"Insulin decreased GLUT4 interactions with the following proteins: Q9ER30 (Sarcosin), P09527 (Rab-7), O88960 (N-ethylmaleimide sensitive), P09456 (PKA I regulatory subunit), P27881 (Hexokinase type II), P07872 (Acyl-coenzyme A oxidase), Q6DGF1 (Isocitrate dehydrogenase), Q9EQX9 (Ubiquitin-conjugating), Q63446 (Polyubiquitin), P24268 (Cathepsin D), Q91XW0 (Heat shock protein 86), Q5FVH0 (unknown), P58405 (Striatin 3), Q62667 (Major vault protein), Q66H50 (unknown), Q09167 (splicing factor), Q9JHU5 (Arfaptin 1)."|comment:"Insulin increased GLUT4 interaction with the following proteins:Q9Z1P2 (R-actinin-1), P45592 (Cofilin), Q9QXQ0 (R-actinin-4), P26473 (ADP-ribosylation factor), P26437 (ADP-ribosylation factor),   Q7TNP1 (Basigin 2), Q6P6R2 (Dihydrolipoamide dehydrogenase),   P04797 (GAPDH), Q63081 (Protein disulfide isomerase), P29457 (47 kDa heat shock protein), Q9R1J8 (Leprecan), O88638 (Putative eps protein),   Q64375 (Synaptonemal complex)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:NDPK - Interactions involving proteins containing InterPro domain IPR001564, Nucleoside diphosphate kinase, core.	taxid:10116(rat-l6)|taxid:10116(Rattus norvegicus)	-	2006/02/15	2021/11/30	rogid:PbFY2lfrty8yw40Jq7ShR7xfuV410116	rogid:Mbujzu7VP6rVyCAUKu78xXo4nXM10116	intact-crc:44F3A2176D02515F|rigid:9RVm0UBcqQF4k06RGKO89Bg16Q8	false	myc tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P19357	uniprotkb:O88761	intact:EBI-915426|uniprotkb:P97900|ensembl:ENSRNOP00000023256	intact:EBI-915698	psi-mi:glut4_rat(display_long)|uniprotkb:Glucose transporter type 4, insulin-responsive(gene name synonym)|uniprotkb:Slc2a4(gene name)|psi-mi:Slc2a4(display_short)|uniprotkb:Glut4(gene name synonym)	psi-mi:psmd1_rat(display_long)|uniprotkb:26S proteasome regulatory subunit RPN2(gene name synonym)|uniprotkb:26S proteasome regulatory subunit S1(gene name synonym)|uniprotkb:26S proteasome subunit p112(gene name synonym)|uniprotkb:Psmd1(gene name)|psi-mi:Psmd1(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Foster et al. (2006)	pubmed:16396496|mint:MINT-5218203	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-921030	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2711|refseq:NP_036883.1|refseq:XP_006246658.1|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007611"(learning or memory)|go:"GO:0007614"(short-term memory)|go:"GO:0007616"(long-term memory)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010021"(amylopectin biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031550"(positive regulation of brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044381"(glucose import in response to insulin stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046323"(glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0098694"(regulation of synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0098793"(presynapse)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002441("Glucose transporter, type 4 (GLUT4)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-189200|ensembl:ENSRNOG00000017226(gene)|ensembl:ENSRNOT00000023256(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)	rgd:621669|refseq:NP_114184.1|interpro:IPR016642(26S proteasome regulatory complex, non-ATPase subcomplex, Rpn2/Psmd1 subunit)|interpro:IPR002015(Proteasome/cyclosome, regulatory subunit)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|go:"GO:0000502"(proteasome complex)|go:"GO:0005634"(nucleus)|go:"GO:0008540"(proteasome regulatory particle, base subcomplex)|go:"GO:0022624"(proteasome accessory complex)|go:"GO:0030234"(enzyme regulator activity)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0034515"(proteasome storage granule)|go:"GO:0042176"(regulation of protein catabolic process)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|reactome:R-RNO-8932339|interpro:IPR040623|interpro:IPR035266|rcsb pdb:6EPC|rcsb pdb:6EPD|rcsb pdb:6EPE|rcsb pdb:6EPF|reactome:R-RNO-174084|reactome:R-RNO-5689603|reactome:R-RNO-5689880|reactome:R-RNO-6798695|reactome:R-RNO-68827|reactome:R-RNO-8951664|reactome:R-RNO-1169091|reactome:R-RNO-1234176|reactome:R-RNO-1236978|reactome:R-RNO-174154|reactome:R-RNO-174178|reactome:R-RNO-174184|reactome:R-RNO-187577|reactome:R-RNO-195253|reactome:R-RNO-2467813|reactome:R-RNO-349425|reactome:R-RNO-350562|reactome:R-RNO-382556|reactome:R-RNO-450408|reactome:R-RNO-4608870|reactome:R-RNO-4641257|reactome:R-RNO-4641258|reactome:R-RNO-5358346|reactome:R-RNO-5607761|reactome:R-RNO-5610780|reactome:R-RNO-5610785|reactome:R-RNO-5632684|reactome:R-RNO-5658442|reactome:R-RNO-5668541|reactome:R-RNO-5676590|reactome:R-RNO-5687128|reactome:R-RNO-68949|reactome:R-RNO-69017|reactome:R-RNO-69481|reactome:R-RNO-69601|reactome:R-RNO-75815|reactome:R-RNO-8852276|reactome:R-RNO-8854050|reactome:R-RNO-8939236|reactome:R-RNO-8941858|reactome:R-RNO-8948751|reactome:R-RNO-983168	-	-	-	caution:"The participant EBI-349571(P68370) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919386(Q7TP47) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920972(Q5XIP9) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-916419(P11980) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919578(Q8R491) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920554(Q5U3Z7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920647(Q5U2X8) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920585(Q7TP24) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-779677(P05426) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-915744(P02454) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|agonist:Insulin was shown to increase or decrease GLUT4 protein interactions in specific cases.|comment:"Insulin decreased GLUT4 interactions with the following proteins: Q9ER30 (Sarcosin), P09527 (Rab-7), O88960 (N-ethylmaleimide sensitive), P09456 (PKA I regulatory subunit), P27881 (Hexokinase type II), P07872 (Acyl-coenzyme A oxidase), Q6DGF1 (Isocitrate dehydrogenase), Q9EQX9 (Ubiquitin-conjugating), Q63446 (Polyubiquitin), P24268 (Cathepsin D), Q91XW0 (Heat shock protein 86), Q5FVH0 (unknown), P58405 (Striatin 3), Q62667 (Major vault protein), Q66H50 (unknown), Q09167 (splicing factor), Q9JHU5 (Arfaptin 1)."|comment:"Insulin increased GLUT4 interaction with the following proteins:Q9Z1P2 (R-actinin-1), P45592 (Cofilin), Q9QXQ0 (R-actinin-4), P26473 (ADP-ribosylation factor), P26437 (ADP-ribosylation factor),   Q7TNP1 (Basigin 2), Q6P6R2 (Dihydrolipoamide dehydrogenase),   P04797 (GAPDH), Q63081 (Protein disulfide isomerase), P29457 (47 kDa heat shock protein), Q9R1J8 (Leprecan), O88638 (Putative eps protein),   Q64375 (Synaptonemal complex)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:NDPK - Interactions involving proteins containing InterPro domain IPR001564, Nucleoside diphosphate kinase, core.	taxid:10116(rat-l6)|taxid:10116(Rattus norvegicus)	-	2006/02/15	2021/11/30	rogid:PbFY2lfrty8yw40Jq7ShR7xfuV410116	rogid:U5l9uQXGOiSSbuoA0e0l3fWy+Bg10116	intact-crc:44F3A2176D02515F|rigid:9RVm0UBcqQF4k06RGKO89Bg16Q8	false	myc tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P19357	uniprotkb:O88656	intact:EBI-915426|uniprotkb:P97900|ensembl:ENSRNOP00000023256	intact:EBI-915692|ensembl:ENSRNOP00000001315	psi-mi:glut4_rat(display_long)|uniprotkb:Glucose transporter type 4, insulin-responsive(gene name synonym)|uniprotkb:Slc2a4(gene name)|psi-mi:Slc2a4(display_short)|uniprotkb:Glut4(gene name synonym)	psi-mi:arc1b_rat(display_long)|uniprotkb:Arp2/3 complex 41 kDa subunit(gene name synonym)|uniprotkb:p41-ARC(gene name synonym)|uniprotkb:Arpc1b(gene name)|psi-mi:Arpc1b(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Foster et al. (2006)	pubmed:16396496|mint:MINT-5218203	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-921030	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2711|refseq:NP_036883.1|refseq:XP_006246658.1|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007611"(learning or memory)|go:"GO:0007614"(short-term memory)|go:"GO:0007616"(long-term memory)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010021"(amylopectin biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031550"(positive regulation of brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044381"(glucose import in response to insulin stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046323"(glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0098694"(regulation of synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0098793"(presynapse)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002441("Glucose transporter, type 4 (GLUT4)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-189200|ensembl:ENSRNOG00000017226(gene)|ensembl:ENSRNOT00000023256(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)	rgd:2155|refseq:NP_062162.1|go:"GO:0032355"(response to estradiol)|go:"GO:0034314"(Arp2/3 complex-mediated actin nucleation)|go:"GO:0036284"(tubulobulbar complex)|go:"GO:0043627"(response to estrogen)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0051015"(actin filament binding)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR017383(Actin-related protein 2/3 complex, subunit 1)|interpro:IPR030141|interpro:IPR036322|reactome:R-RNO-2029482|reactome:R-RNO-3928662|reactome:R-RNO-5663213|ensembl:ENSRNOG00000000991(gene)|ensembl:ENSRNOT00000001315(transcript)|go:"GO:0005200"(structural constituent of cytoskeleton)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005885"(Arp2/3 protein complex)	-	-	-	caution:"The participant EBI-349571(P68370) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919386(Q7TP47) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920972(Q5XIP9) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-916419(P11980) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919578(Q8R491) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920554(Q5U3Z7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920647(Q5U2X8) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920585(Q7TP24) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-779677(P05426) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-915744(P02454) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|agonist:Insulin was shown to increase or decrease GLUT4 protein interactions in specific cases.|comment:"Insulin decreased GLUT4 interactions with the following proteins: Q9ER30 (Sarcosin), P09527 (Rab-7), O88960 (N-ethylmaleimide sensitive), P09456 (PKA I regulatory subunit), P27881 (Hexokinase type II), P07872 (Acyl-coenzyme A oxidase), Q6DGF1 (Isocitrate dehydrogenase), Q9EQX9 (Ubiquitin-conjugating), Q63446 (Polyubiquitin), P24268 (Cathepsin D), Q91XW0 (Heat shock protein 86), Q5FVH0 (unknown), P58405 (Striatin 3), Q62667 (Major vault protein), Q66H50 (unknown), Q09167 (splicing factor), Q9JHU5 (Arfaptin 1)."|comment:"Insulin increased GLUT4 interaction with the following proteins:Q9Z1P2 (R-actinin-1), P45592 (Cofilin), Q9QXQ0 (R-actinin-4), P26473 (ADP-ribosylation factor), P26437 (ADP-ribosylation factor),   Q7TNP1 (Basigin 2), Q6P6R2 (Dihydrolipoamide dehydrogenase),   P04797 (GAPDH), Q63081 (Protein disulfide isomerase), P29457 (47 kDa heat shock protein), Q9R1J8 (Leprecan), O88638 (Putative eps protein),   Q64375 (Synaptonemal complex)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:NDPK - Interactions involving proteins containing InterPro domain IPR001564, Nucleoside diphosphate kinase, core.	taxid:10116(rat-l6)|taxid:10116(Rattus norvegicus)	-	2006/02/15	2021/11/30	rogid:PbFY2lfrty8yw40Jq7ShR7xfuV410116	rogid:Y2msuN8aSc7d2hQ/i1E96TQxdEw10116	intact-crc:44F3A2176D02515F|rigid:9RVm0UBcqQF4k06RGKO89Bg16Q8	false	myc tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P19357	uniprotkb:O88638	intact:EBI-915426|uniprotkb:P97900|ensembl:ENSRNOP00000023256	intact:EBI-915684	psi-mi:glut4_rat(display_long)|uniprotkb:Glucose transporter type 4, insulin-responsive(gene name synonym)|uniprotkb:Slc2a4(gene name)|psi-mi:Slc2a4(display_short)|uniprotkb:Glut4(gene name synonym)	psi-mi:o88638_rat(display_long)|uniprotkb:MGEPS(gene name)|psi-mi:MGEPS(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Foster et al. (2006)	pubmed:16396496|mint:MINT-5218203	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-921030	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2711|refseq:NP_036883.1|refseq:XP_006246658.1|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007611"(learning or memory)|go:"GO:0007614"(short-term memory)|go:"GO:0007616"(long-term memory)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010021"(amylopectin biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031550"(positive regulation of brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044381"(glucose import in response to insulin stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046323"(glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0098694"(regulation of synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0098793"(presynapse)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002441("Glucose transporter, type 4 (GLUT4)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-189200|ensembl:ENSRNOG00000017226(gene)|ensembl:ENSRNOT00000023256(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)	interpro:IPR011992(EF-Hand type)|interpro:IPR018247|interpro:IPR000261("EPS15 homology (EH)")|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0032456"(endocytic recycling)|interpro:IPR029945	-	-	-	caution:"The participant EBI-349571(P68370) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919386(Q7TP47) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920972(Q5XIP9) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-916419(P11980) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919578(Q8R491) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920554(Q5U3Z7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920647(Q5U2X8) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920585(Q7TP24) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-779677(P05426) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-915744(P02454) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|agonist:Insulin was shown to increase or decrease GLUT4 protein interactions in specific cases.|comment:"Insulin decreased GLUT4 interactions with the following proteins: Q9ER30 (Sarcosin), P09527 (Rab-7), O88960 (N-ethylmaleimide sensitive), P09456 (PKA I regulatory subunit), P27881 (Hexokinase type II), P07872 (Acyl-coenzyme A oxidase), Q6DGF1 (Isocitrate dehydrogenase), Q9EQX9 (Ubiquitin-conjugating), Q63446 (Polyubiquitin), P24268 (Cathepsin D), Q91XW0 (Heat shock protein 86), Q5FVH0 (unknown), P58405 (Striatin 3), Q62667 (Major vault protein), Q66H50 (unknown), Q09167 (splicing factor), Q9JHU5 (Arfaptin 1)."|comment:"Insulin increased GLUT4 interaction with the following proteins:Q9Z1P2 (R-actinin-1), P45592 (Cofilin), Q9QXQ0 (R-actinin-4), P26473 (ADP-ribosylation factor), P26437 (ADP-ribosylation factor),   Q7TNP1 (Basigin 2), Q6P6R2 (Dihydrolipoamide dehydrogenase),   P04797 (GAPDH), Q63081 (Protein disulfide isomerase), P29457 (47 kDa heat shock protein), Q9R1J8 (Leprecan), O88638 (Putative eps protein),   Q64375 (Synaptonemal complex)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:NDPK - Interactions involving proteins containing InterPro domain IPR001564, Nucleoside diphosphate kinase, core.	taxid:10116(rat-l6)|taxid:10116(Rattus norvegicus)	-	2006/02/15	2021/11/30	rogid:PbFY2lfrty8yw40Jq7ShR7xfuV410116	rogid:b3RMxlVcDulMF07AP3CIEib7k+410116	intact-crc:44F3A2176D02515F|rigid:9RVm0UBcqQF4k06RGKO89Bg16Q8	false	myc tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P19357	uniprotkb:O88989	intact:EBI-915426|uniprotkb:P97900|ensembl:ENSRNOP00000023256	intact:EBI-915677|uniprotkb:O88585|uniprotkb:Q6PCV2|ensembl:ENSRNOP00000011429	psi-mi:glut4_rat(display_long)|uniprotkb:Glucose transporter type 4, insulin-responsive(gene name synonym)|uniprotkb:Slc2a4(gene name)|psi-mi:Slc2a4(display_short)|uniprotkb:Glut4(gene name synonym)	psi-mi:mdhc_rat(display_long)|uniprotkb:Cytosolic malate dehydrogenase(gene name synonym)|uniprotkb:Mdh1(gene name)|psi-mi:Mdh1(display_short)|uniprotkb:Mdh(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Foster et al. (2006)	pubmed:16396496|mint:MINT-5218203	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-921030	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2711|refseq:NP_036883.1|refseq:XP_006246658.1|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007611"(learning or memory)|go:"GO:0007614"(short-term memory)|go:"GO:0007616"(long-term memory)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010021"(amylopectin biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031550"(positive regulation of brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044381"(glucose import in response to insulin stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046323"(glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0098694"(regulation of synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0098793"(presynapse)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002441("Glucose transporter, type 4 (GLUT4)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-189200|ensembl:ENSRNOG00000017226(gene)|ensembl:ENSRNOT00000023256(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)	rgd:3072|refseq:NP_150238.1|ensembl:ENSRNOG00000008103(gene)|ensembl:ENSRNOT00000011429(transcript)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005975"(carbohydrate metabolic process)|go:"GO:0006099"(tricarboxylic acid cycle)|go:"GO:0006107"(oxaloacetate metabolic process)|go:"GO:0006108"(malate metabolic process)|go:"GO:0006734"(NADH metabolic process)|go:"GO:0016615"(malate dehydrogenase activity)|go:"GO:0019674"(NAD metabolic process)|go:"GO:0030060"(L-malate dehydrogenase activity)|go:"GO:0051287"(NAD binding)|interpro:IPR001236(Lactate/malate dehydrogenase)|interpro:IPR001252(Malate dehydrogenase, active site)|interpro:IPR001557(L-lactate/malate dehydrogenase)|interpro:IPR010945(Malate dehydrogenase, NAD or NADP)|interpro:IPR011274(Malate dehydrogenase, NAD-dependent, cytosolic)|interpro:IPR015955(Lactate dehydrogenase/glycoside hydrolase, family 4, C-terminal)|interpro:IPR022383|interpro:IPR036291|reactome:R-RNO-70263	-	-	-	caution:"The participant EBI-349571(P68370) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919386(Q7TP47) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920972(Q5XIP9) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-916419(P11980) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919578(Q8R491) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920554(Q5U3Z7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920647(Q5U2X8) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920585(Q7TP24) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-779677(P05426) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-915744(P02454) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|agonist:Insulin was shown to increase or decrease GLUT4 protein interactions in specific cases.|comment:"Insulin decreased GLUT4 interactions with the following proteins: Q9ER30 (Sarcosin), P09527 (Rab-7), O88960 (N-ethylmaleimide sensitive), P09456 (PKA I regulatory subunit), P27881 (Hexokinase type II), P07872 (Acyl-coenzyme A oxidase), Q6DGF1 (Isocitrate dehydrogenase), Q9EQX9 (Ubiquitin-conjugating), Q63446 (Polyubiquitin), P24268 (Cathepsin D), Q91XW0 (Heat shock protein 86), Q5FVH0 (unknown), P58405 (Striatin 3), Q62667 (Major vault protein), Q66H50 (unknown), Q09167 (splicing factor), Q9JHU5 (Arfaptin 1)."|comment:"Insulin increased GLUT4 interaction with the following proteins:Q9Z1P2 (R-actinin-1), P45592 (Cofilin), Q9QXQ0 (R-actinin-4), P26473 (ADP-ribosylation factor), P26437 (ADP-ribosylation factor),   Q7TNP1 (Basigin 2), Q6P6R2 (Dihydrolipoamide dehydrogenase),   P04797 (GAPDH), Q63081 (Protein disulfide isomerase), P29457 (47 kDa heat shock protein), Q9R1J8 (Leprecan), O88638 (Putative eps protein),   Q64375 (Synaptonemal complex)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:NDPK - Interactions involving proteins containing InterPro domain IPR001564, Nucleoside diphosphate kinase, core.	taxid:10116(rat-l6)|taxid:10116(Rattus norvegicus)	-	2006/02/15	2021/11/30	rogid:PbFY2lfrty8yw40Jq7ShR7xfuV410116	rogid:vMzNnA+o4njBSH4waXy1SUSrpvE10116	intact-crc:44F3A2176D02515F|rigid:9RVm0UBcqQF4k06RGKO89Bg16Q8	false	myc tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P19357	uniprotkb:M0RC99	intact:EBI-915426|uniprotkb:P97900|ensembl:ENSRNOP00000023256	intact:EBI-915664|uniprotkb:O88565	psi-mi:glut4_rat(display_long)|uniprotkb:Glucose transporter type 4, insulin-responsive(gene name synonym)|uniprotkb:Slc2a4(gene name)|psi-mi:Slc2a4(display_short)|uniprotkb:Glut4(gene name synonym)	psi-mi:rab5a_rat(display_long)|uniprotkb:Rab5a(gene name)|psi-mi:Rab5a(display_short)|uniprotkb:Small GTP-binding protein rab5(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Foster et al. (2006)	pubmed:16396496|mint:MINT-5218203	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-921030	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2711|refseq:NP_036883.1|refseq:XP_006246658.1|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007611"(learning or memory)|go:"GO:0007614"(short-term memory)|go:"GO:0007616"(long-term memory)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010021"(amylopectin biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031550"(positive regulation of brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044381"(glucose import in response to insulin stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046323"(glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0098694"(regulation of synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0098793"(presynapse)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002441("Glucose transporter, type 4 (GLUT4)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-189200|ensembl:ENSRNOG00000017226(gene)|ensembl:ENSRNOT00000023256(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)	interpro:IPR005225(Small GTP-binding protein)|interpro:IPR001806(Ras GTPase)|refseq:NP_073183.1|refseq:XP_003751425.1|refseq:XP_003752788.1|interpro:IPR027417|rgd:620936|mint:M0RC99|go:"GO:0001726"(ruffle)|go:"GO:0003924"(GTPase activity)|go:"GO:0003925"(G protein activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005769"(early endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006897"(endocytosis)|go:"GO:0006909"(phagocytosis)|go:"GO:0007032"(endosome organization)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0010008"(endosome membrane)|go:"GO:0012505"(endomembrane system)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0019001"(guanyl nucleotide binding)|go:"GO:0019003"(GDP binding)|go:"GO:0030100"(regulation of endocytosis)|go:"GO:0030139"(endocytic vesicle)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030670"(phagocytic vesicle membrane)|go:"GO:0032009"(early phagosome)|go:"GO:0032991"(protein-containing complex)|go:"GO:0036465"(synaptic vesicle recycling)|go:"GO:0036477"(somatodendritic compartment)|go:"GO:0039694"(viral RNA genome replication)|go:"GO:0042470"(melanosome)|go:"GO:0042589"(zymogen granule membrane)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043195"(terminal bouton)|go:"GO:0043679"(axon terminus)|go:"GO:0045022"(early endosome to late endosome transport)|go:"GO:0045121"(membrane raft)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0045921"(positive regulation of exocytosis)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0051021"(GDP-dissociation inhibitor binding)|go:"GO:0051036"(regulation of endosome size)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0055037"(recycling endosome)|go:"GO:0098559"(cytoplasmic side of early endosome membrane)|go:"GO:0098842"(postsynaptic early endosome)|go:"GO:0098993"(anchored component of synaptic vesicle membrane)|go:"GO:0150093"(amyloid-beta clearance by transcytosis)|go:"GO:2000286"(receptor internalization involved in canonical Wnt signaling pathway)|go:"GO:2000300"(regulation of synaptic vesicle exocytosis)	-	-	-	caution:"The participant EBI-349571(P68370) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919386(Q7TP47) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920972(Q5XIP9) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-916419(P11980) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919578(Q8R491) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920554(Q5U3Z7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920647(Q5U2X8) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920585(Q7TP24) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-779677(P05426) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-915744(P02454) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|agonist:Insulin was shown to increase or decrease GLUT4 protein interactions in specific cases.|comment:"Insulin decreased GLUT4 interactions with the following proteins: Q9ER30 (Sarcosin), P09527 (Rab-7), O88960 (N-ethylmaleimide sensitive), P09456 (PKA I regulatory subunit), P27881 (Hexokinase type II), P07872 (Acyl-coenzyme A oxidase), Q6DGF1 (Isocitrate dehydrogenase), Q9EQX9 (Ubiquitin-conjugating), Q63446 (Polyubiquitin), P24268 (Cathepsin D), Q91XW0 (Heat shock protein 86), Q5FVH0 (unknown), P58405 (Striatin 3), Q62667 (Major vault protein), Q66H50 (unknown), Q09167 (splicing factor), Q9JHU5 (Arfaptin 1)."|comment:"Insulin increased GLUT4 interaction with the following proteins:Q9Z1P2 (R-actinin-1), P45592 (Cofilin), Q9QXQ0 (R-actinin-4), P26473 (ADP-ribosylation factor), P26437 (ADP-ribosylation factor),   Q7TNP1 (Basigin 2), Q6P6R2 (Dihydrolipoamide dehydrogenase),   P04797 (GAPDH), Q63081 (Protein disulfide isomerase), P29457 (47 kDa heat shock protein), Q9R1J8 (Leprecan), O88638 (Putative eps protein),   Q64375 (Synaptonemal complex)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:NDPK - Interactions involving proteins containing InterPro domain IPR001564, Nucleoside diphosphate kinase, core.	taxid:10116(rat-l6)|taxid:10116(Rattus norvegicus)	-	2006/02/15	2021/11/30	rogid:PbFY2lfrty8yw40Jq7ShR7xfuV410116	rogid:YQ/5pW5C9bIfRqb10F4QJKJXrGI10116	intact-crc:44F3A2176D02515F|rigid:9RVm0UBcqQF4k06RGKO89Bg16Q8	false	myc tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P19357	uniprotkb:G3V7P1	intact:EBI-915426|uniprotkb:P97900|ensembl:ENSRNOP00000023256	intact:EBI-915654|uniprotkb:O70319|uniprotkb:O88385|ensembl:ENSRNOP00000017227	psi-mi:glut4_rat(display_long)|uniprotkb:Glucose transporter type 4, insulin-responsive(gene name synonym)|uniprotkb:Slc2a4(gene name)|psi-mi:Slc2a4(display_short)|uniprotkb:Glut4(gene name synonym)	psi-mi:stx12_rat(display_long)|uniprotkb:Stx12(gene name)|psi-mi:Stx12(display_short)|uniprotkb:Stx13(gene name synonym)|uniprotkb:Syntaxin-13(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Foster et al. (2006)	pubmed:16396496|mint:MINT-5218203	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-921030	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2711|refseq:NP_036883.1|refseq:XP_006246658.1|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007611"(learning or memory)|go:"GO:0007614"(short-term memory)|go:"GO:0007616"(long-term memory)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010021"(amylopectin biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031550"(positive regulation of brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044381"(glucose import in response to insulin stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046323"(glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0098694"(regulation of synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0098793"(presynapse)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002441("Glucose transporter, type 4 (GLUT4)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-189200|ensembl:ENSRNOG00000017226(gene)|ensembl:ENSRNOT00000023256(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)	rgd:620977|refseq:NP_075228.2|ensembl:ENSRNOG00000011804(gene)|ensembl:ENSRNOT00000017227(transcript)|go:"GO:0000045"(autophagosome assembly)|go:"GO:0000139"(Golgi membrane)|go:"GO:0000149"(SNARE binding)|go:"GO:0000407"(phagophore assembly site)|go:"GO:0005484"(SNAP receptor activity)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006906"(vesicle fusion)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0012505"(endomembrane system)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016189"(synaptic vesicle to endosome fusion)|go:"GO:0030285"(integral component of synaptic vesicle membrane)|go:"GO:0031201"(SNARE complex)|go:"GO:0031901"(early endosome membrane)|go:"GO:0031982"(vesicle)|go:"GO:0033344"(cholesterol efflux)|go:"GO:0045121"(membrane raft)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0048278"(vesicle docking)|go:"GO:0050821"(protein stabilization)|go:"GO:0055038"(recycling endosome membrane)|go:"GO:0098837"(postsynaptic recycling endosome)|interpro:IPR000727(Target SNARE coiled-coil region)|interpro:IPR006011(Syntaxin, N-terminal)|interpro:IPR006012(Syntaxin/epimorphin, conserved site)|interpro:IPR010989(t-SNARE)|mint:G3V7P1|rcsb pdb:2NPS	-	-	-	caution:"The participant EBI-349571(P68370) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919386(Q7TP47) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920972(Q5XIP9) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-916419(P11980) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919578(Q8R491) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920554(Q5U3Z7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920647(Q5U2X8) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920585(Q7TP24) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-779677(P05426) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-915744(P02454) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|agonist:Insulin was shown to increase or decrease GLUT4 protein interactions in specific cases.|comment:"Insulin decreased GLUT4 interactions with the following proteins: Q9ER30 (Sarcosin), P09527 (Rab-7), O88960 (N-ethylmaleimide sensitive), P09456 (PKA I regulatory subunit), P27881 (Hexokinase type II), P07872 (Acyl-coenzyme A oxidase), Q6DGF1 (Isocitrate dehydrogenase), Q9EQX9 (Ubiquitin-conjugating), Q63446 (Polyubiquitin), P24268 (Cathepsin D), Q91XW0 (Heat shock protein 86), Q5FVH0 (unknown), P58405 (Striatin 3), Q62667 (Major vault protein), Q66H50 (unknown), Q09167 (splicing factor), Q9JHU5 (Arfaptin 1)."|comment:"Insulin increased GLUT4 interaction with the following proteins:Q9Z1P2 (R-actinin-1), P45592 (Cofilin), Q9QXQ0 (R-actinin-4), P26473 (ADP-ribosylation factor), P26437 (ADP-ribosylation factor),   Q7TNP1 (Basigin 2), Q6P6R2 (Dihydrolipoamide dehydrogenase),   P04797 (GAPDH), Q63081 (Protein disulfide isomerase), P29457 (47 kDa heat shock protein), Q9R1J8 (Leprecan), O88638 (Putative eps protein),   Q64375 (Synaptonemal complex)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:NDPK - Interactions involving proteins containing InterPro domain IPR001564, Nucleoside diphosphate kinase, core.	taxid:10116(rat-l6)|taxid:10116(Rattus norvegicus)	-	2006/02/15	2021/11/30	rogid:PbFY2lfrty8yw40Jq7ShR7xfuV410116	rogid:HrZ1eN7bur9OxIkSP7hIfIugdOs10116	intact-crc:44F3A2176D02515F|rigid:9RVm0UBcqQF4k06RGKO89Bg16Q8	false	myc tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P19357	uniprotkb:Q5U1Z2	intact:EBI-915426|uniprotkb:P97900|ensembl:ENSRNOP00000023256	intact:EBI-921025|ensembl:ENSRNOP00000014383	psi-mi:glut4_rat(display_long)|uniprotkb:Glucose transporter type 4, insulin-responsive(gene name synonym)|uniprotkb:Slc2a4(gene name)|psi-mi:Slc2a4(display_short)|uniprotkb:Glut4(gene name synonym)	psi-mi:tppc3_rat(display_long)|uniprotkb:Trappc3(gene name)|psi-mi:Trappc3(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Foster et al. (2006)	pubmed:16396496|mint:MINT-5218203	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-921030	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2711|refseq:NP_036883.1|refseq:XP_006246658.1|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007611"(learning or memory)|go:"GO:0007614"(short-term memory)|go:"GO:0007616"(long-term memory)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010021"(amylopectin biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031550"(positive regulation of brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044381"(glucose import in response to insulin stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046323"(glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0098694"(regulation of synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0098793"(presynapse)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002441("Glucose transporter, type 4 (GLUT4)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-189200|ensembl:ENSRNOG00000017226(gene)|ensembl:ENSRNOT00000023256(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)	rgd:1309135|refseq:NP_001008377.1|ensembl:ENSRNOG00000010550(gene)|ensembl:ENSRNOT00000014383(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0006888"(endoplasmic reticulum to Golgi vesicle-mediated transport)|go:"GO:0006891"(intra-Golgi vesicle-mediated transport)|go:"GO:0030008"(TRAPP complex)|go:"GO:0033106"(cis-Golgi network membrane)|interpro:IPR007194("Transport protein particle (TRAPP) component, Bet3")|interpro:IPR016721(TRAPP I complex, Bet3)|interpro:IPR024096|mint:Q5U1Z2|reactome:R-RNO-204005|reactome:R-RNO-8876198	-	-	-	caution:"The participant EBI-349571(P68370) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919386(Q7TP47) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920972(Q5XIP9) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-916419(P11980) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919578(Q8R491) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920554(Q5U3Z7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920647(Q5U2X8) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920585(Q7TP24) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-779677(P05426) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-915744(P02454) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|agonist:Insulin was shown to increase or decrease GLUT4 protein interactions in specific cases.|comment:"Insulin decreased GLUT4 interactions with the following proteins: Q9ER30 (Sarcosin), P09527 (Rab-7), O88960 (N-ethylmaleimide sensitive), P09456 (PKA I regulatory subunit), P27881 (Hexokinase type II), P07872 (Acyl-coenzyme A oxidase), Q6DGF1 (Isocitrate dehydrogenase), Q9EQX9 (Ubiquitin-conjugating), Q63446 (Polyubiquitin), P24268 (Cathepsin D), Q91XW0 (Heat shock protein 86), Q5FVH0 (unknown), P58405 (Striatin 3), Q62667 (Major vault protein), Q66H50 (unknown), Q09167 (splicing factor), Q9JHU5 (Arfaptin 1)."|comment:"Insulin increased GLUT4 interaction with the following proteins:Q9Z1P2 (R-actinin-1), P45592 (Cofilin), Q9QXQ0 (R-actinin-4), P26473 (ADP-ribosylation factor), P26437 (ADP-ribosylation factor),   Q7TNP1 (Basigin 2), Q6P6R2 (Dihydrolipoamide dehydrogenase),   P04797 (GAPDH), Q63081 (Protein disulfide isomerase), P29457 (47 kDa heat shock protein), Q9R1J8 (Leprecan), O88638 (Putative eps protein),   Q64375 (Synaptonemal complex)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:NDPK - Interactions involving proteins containing InterPro domain IPR001564, Nucleoside diphosphate kinase, core.	taxid:10116(rat-l6)|taxid:10116(Rattus norvegicus)	-	2006/02/15	2021/11/30	rogid:PbFY2lfrty8yw40Jq7ShR7xfuV410116	rogid:VoANjtqe/P6oziS0WRdNJprvMUI10116	intact-crc:44F3A2176D02515F|rigid:9RVm0UBcqQF4k06RGKO89Bg16Q8	false	myc tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P19357	uniprotkb:Q52KJ9	intact:EBI-915426|uniprotkb:P97900|ensembl:ENSRNOP00000023256	intact:EBI-921013|ensembl:ENSRNOP00000071802	psi-mi:glut4_rat(display_long)|uniprotkb:Glucose transporter type 4, insulin-responsive(gene name synonym)|uniprotkb:Slc2a4(gene name)|psi-mi:Slc2a4(display_short)|uniprotkb:Glut4(gene name synonym)	psi-mi:q52kj9_rat(display_long)|uniprotkb:Tmx1(gene name)|psi-mi:Tmx1(display_short)|uniprotkb:Txndc1(gene name synonym)|uniprotkb:rCG_62384(orf name)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Foster et al. (2006)	pubmed:16396496|mint:MINT-5218203	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-921030	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2711|refseq:NP_036883.1|refseq:XP_006246658.1|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007611"(learning or memory)|go:"GO:0007614"(short-term memory)|go:"GO:0007616"(long-term memory)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010021"(amylopectin biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031550"(positive regulation of brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044381"(glucose import in response to insulin stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046323"(glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0098694"(regulation of synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0098793"(presynapse)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002441("Glucose transporter, type 4 (GLUT4)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-189200|ensembl:ENSRNOG00000017226(gene)|ensembl:ENSRNOT00000023256(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)	rgd:1308455|refseq:NP_001019971.1|go:"GO:0016021"(integral component of membrane)|go:"GO:0034976"(response to endoplasmic reticulum stress)|interpro:IPR013766(Thioredoxin domain)|interpro:IPR017937|interpro:IPR036249|ensembl:ENSRNOG00000057934(gene)|ensembl:ENSRNOT00000087540(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0015036"(disulfide oxidoreductase activity)	-	-	-	caution:"The participant EBI-349571(P68370) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919386(Q7TP47) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920972(Q5XIP9) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-916419(P11980) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919578(Q8R491) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920554(Q5U3Z7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920647(Q5U2X8) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920585(Q7TP24) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-779677(P05426) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-915744(P02454) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|agonist:Insulin was shown to increase or decrease GLUT4 protein interactions in specific cases.|comment:"Insulin decreased GLUT4 interactions with the following proteins: Q9ER30 (Sarcosin), P09527 (Rab-7), O88960 (N-ethylmaleimide sensitive), P09456 (PKA I regulatory subunit), P27881 (Hexokinase type II), P07872 (Acyl-coenzyme A oxidase), Q6DGF1 (Isocitrate dehydrogenase), Q9EQX9 (Ubiquitin-conjugating), Q63446 (Polyubiquitin), P24268 (Cathepsin D), Q91XW0 (Heat shock protein 86), Q5FVH0 (unknown), P58405 (Striatin 3), Q62667 (Major vault protein), Q66H50 (unknown), Q09167 (splicing factor), Q9JHU5 (Arfaptin 1)."|comment:"Insulin increased GLUT4 interaction with the following proteins:Q9Z1P2 (R-actinin-1), P45592 (Cofilin), Q9QXQ0 (R-actinin-4), P26473 (ADP-ribosylation factor), P26437 (ADP-ribosylation factor),   Q7TNP1 (Basigin 2), Q6P6R2 (Dihydrolipoamide dehydrogenase),   P04797 (GAPDH), Q63081 (Protein disulfide isomerase), P29457 (47 kDa heat shock protein), Q9R1J8 (Leprecan), O88638 (Putative eps protein),   Q64375 (Synaptonemal complex)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:NDPK - Interactions involving proteins containing InterPro domain IPR001564, Nucleoside diphosphate kinase, core.	taxid:10116(rat-l6)|taxid:10116(Rattus norvegicus)	-	2006/02/15	2021/11/30	rogid:PbFY2lfrty8yw40Jq7ShR7xfuV410116	rogid:wUeHQzV1jdTo5/0TByspjrZgvW010116	intact-crc:44F3A2176D02515F|rigid:9RVm0UBcqQF4k06RGKO89Bg16Q8	false	myc tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P19357	uniprotkb:Q5BK63	intact:EBI-915426|uniprotkb:P97900|ensembl:ENSRNOP00000023256	intact:EBI-921005|uniprotkb:B5DER7|ensembl:ENSRNOP00000072757	psi-mi:glut4_rat(display_long)|uniprotkb:Glucose transporter type 4, insulin-responsive(gene name synonym)|uniprotkb:Slc2a4(gene name)|psi-mi:Slc2a4(display_short)|uniprotkb:Glut4(gene name synonym)	psi-mi:ndua9_rat(display_long)|uniprotkb:Ndufa9(gene name)|psi-mi:Ndufa9(display_short)|uniprotkb:NADH-ubiquinone oxidoreductase 39 kDa subunit(gene name synonym)|uniprotkb:Complex I-39kD(gene name synonym)|uniprotkb:Sperm flagella protein 3(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Foster et al. (2006)	pubmed:16396496|mint:MINT-5218203	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-921030	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2711|refseq:NP_036883.1|refseq:XP_006246658.1|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007611"(learning or memory)|go:"GO:0007614"(short-term memory)|go:"GO:0007616"(long-term memory)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010021"(amylopectin biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031550"(positive regulation of brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044381"(glucose import in response to insulin stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046323"(glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0098694"(regulation of synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0098793"(presynapse)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002441("Glucose transporter, type 4 (GLUT4)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-189200|ensembl:ENSRNOG00000017226(gene)|ensembl:ENSRNOT00000023256(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)	rgd:1307307|refseq:NP_001094222.1|ensembl:ENSRNOG00000061684(gene)|ensembl:ENSRNOT00000089193(transcript)|go:"GO:0003954"(NADH dehydrogenase activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005747"(mitochondrial respiratory chain complex I)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0007623"(circadian rhythm)|go:"GO:0009749"(response to glucose)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0032981"(mitochondrial respiratory chain complex I assembly)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:1901006"(ubiquinone-6 biosynthetic process)|interpro:IPR008030(NmrA-like)|interpro:IPR036291|mint:Q5BK63|reactome:R-RNO-611105|reactome:R-RNO-6799198	-	-	-	caution:"The participant EBI-349571(P68370) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919386(Q7TP47) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920972(Q5XIP9) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-916419(P11980) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919578(Q8R491) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920554(Q5U3Z7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920647(Q5U2X8) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920585(Q7TP24) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-779677(P05426) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-915744(P02454) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|agonist:Insulin was shown to increase or decrease GLUT4 protein interactions in specific cases.|comment:"Insulin decreased GLUT4 interactions with the following proteins: Q9ER30 (Sarcosin), P09527 (Rab-7), O88960 (N-ethylmaleimide sensitive), P09456 (PKA I regulatory subunit), P27881 (Hexokinase type II), P07872 (Acyl-coenzyme A oxidase), Q6DGF1 (Isocitrate dehydrogenase), Q9EQX9 (Ubiquitin-conjugating), Q63446 (Polyubiquitin), P24268 (Cathepsin D), Q91XW0 (Heat shock protein 86), Q5FVH0 (unknown), P58405 (Striatin 3), Q62667 (Major vault protein), Q66H50 (unknown), Q09167 (splicing factor), Q9JHU5 (Arfaptin 1)."|comment:"Insulin increased GLUT4 interaction with the following proteins:Q9Z1P2 (R-actinin-1), P45592 (Cofilin), Q9QXQ0 (R-actinin-4), P26473 (ADP-ribosylation factor), P26437 (ADP-ribosylation factor),   Q7TNP1 (Basigin 2), Q6P6R2 (Dihydrolipoamide dehydrogenase),   P04797 (GAPDH), Q63081 (Protein disulfide isomerase), P29457 (47 kDa heat shock protein), Q9R1J8 (Leprecan), O88638 (Putative eps protein),   Q64375 (Synaptonemal complex)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:NDPK - Interactions involving proteins containing InterPro domain IPR001564, Nucleoside diphosphate kinase, core.	taxid:10116(rat-l6)|taxid:10116(Rattus norvegicus)	-	2006/02/15	2021/11/30	rogid:PbFY2lfrty8yw40Jq7ShR7xfuV410116	rogid:xF94AhPCBeZhicTmqc9oEprpUi410116	intact-crc:44F3A2176D02515F|rigid:9RVm0UBcqQF4k06RGKO89Bg16Q8	false	myc tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P19357	uniprotkb:Q499V7	intact:EBI-915426|uniprotkb:P97900|ensembl:ENSRNOP00000023256	intact:EBI-920997	psi-mi:glut4_rat(display_long)|uniprotkb:Glucose transporter type 4, insulin-responsive(gene name synonym)|uniprotkb:Slc2a4(gene name)|psi-mi:Slc2a4(display_short)|uniprotkb:Glut4(gene name synonym)	psi-mi:q499v7_rat(display_long)|uniprotkb:Suclg2(gene name)|psi-mi:Suclg2(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Foster et al. (2006)	pubmed:16396496|mint:MINT-5218203	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-921030	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2711|refseq:NP_036883.1|refseq:XP_006246658.1|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007611"(learning or memory)|go:"GO:0007614"(short-term memory)|go:"GO:0007616"(long-term memory)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010021"(amylopectin biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031550"(positive regulation of brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044381"(glucose import in response to insulin stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046323"(glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0098694"(regulation of synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0098793"(presynapse)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002441("Glucose transporter, type 4 (GLUT4)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-189200|ensembl:ENSRNOG00000017226(gene)|ensembl:ENSRNOT00000023256(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)	interpro:IPR011761(ATP-grasp fold)|interpro:IPR013650(ATP-grasp fold, succinyl-CoA synthetase-type)|interpro:IPR013815(ATP-grasp fold, subdomain 1)|interpro:IPR005811(ATP-citrate lyase/succinyl-CoA ligase)|interpro:IPR017866|interpro:IPR005809(Succinyl-CoA synthetase, beta subunit)|interpro:IPR016102(Succinyl-CoA synthetase-like)|interpro:IPR034722|go:"GO:0004776"("succinate-CoA ligase (GDP-forming) activity")|go:"GO:0005524"(ATP binding)|go:"GO:0005525"(GTP binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0006099"(tricarboxylic acid cycle)|go:"GO:0006104"(succinyl-CoA metabolic process)|go:"GO:0046872"(metal ion binding)	-	-	-	caution:"The participant EBI-349571(P68370) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919386(Q7TP47) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920972(Q5XIP9) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-916419(P11980) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919578(Q8R491) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920554(Q5U3Z7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920647(Q5U2X8) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920585(Q7TP24) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-779677(P05426) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-915744(P02454) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|agonist:Insulin was shown to increase or decrease GLUT4 protein interactions in specific cases.|comment:"Insulin decreased GLUT4 interactions with the following proteins: Q9ER30 (Sarcosin), P09527 (Rab-7), O88960 (N-ethylmaleimide sensitive), P09456 (PKA I regulatory subunit), P27881 (Hexokinase type II), P07872 (Acyl-coenzyme A oxidase), Q6DGF1 (Isocitrate dehydrogenase), Q9EQX9 (Ubiquitin-conjugating), Q63446 (Polyubiquitin), P24268 (Cathepsin D), Q91XW0 (Heat shock protein 86), Q5FVH0 (unknown), P58405 (Striatin 3), Q62667 (Major vault protein), Q66H50 (unknown), Q09167 (splicing factor), Q9JHU5 (Arfaptin 1)."|comment:"Insulin increased GLUT4 interaction with the following proteins:Q9Z1P2 (R-actinin-1), P45592 (Cofilin), Q9QXQ0 (R-actinin-4), P26473 (ADP-ribosylation factor), P26437 (ADP-ribosylation factor),   Q7TNP1 (Basigin 2), Q6P6R2 (Dihydrolipoamide dehydrogenase),   P04797 (GAPDH), Q63081 (Protein disulfide isomerase), P29457 (47 kDa heat shock protein), Q9R1J8 (Leprecan), O88638 (Putative eps protein),   Q64375 (Synaptonemal complex)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:NDPK - Interactions involving proteins containing InterPro domain IPR001564, Nucleoside diphosphate kinase, core.	taxid:10116(rat-l6)|taxid:10116(Rattus norvegicus)	-	2006/02/15	2021/11/30	rogid:PbFY2lfrty8yw40Jq7ShR7xfuV410116	rogid:lQD/2BVRN818R1v3ETXvRXzE+WE10116	intact-crc:44F3A2176D02515F|rigid:9RVm0UBcqQF4k06RGKO89Bg16Q8	false	myc tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P19357	uniprotkb:Q5EBA9	intact:EBI-915426|uniprotkb:P97900|ensembl:ENSRNOP00000023256	intact:EBI-920987	psi-mi:glut4_rat(display_long)|uniprotkb:Glucose transporter type 4, insulin-responsive(gene name synonym)|uniprotkb:Slc2a4(gene name)|psi-mi:Slc2a4(display_short)|uniprotkb:Glut4(gene name synonym)	psi-mi:q5eba9_rat(display_long)|uniprotkb:Suclg2(gene name)|psi-mi:Suclg2(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Foster et al. (2006)	pubmed:16396496|mint:MINT-5218203	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-921030	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2711|refseq:NP_036883.1|refseq:XP_006246658.1|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007611"(learning or memory)|go:"GO:0007614"(short-term memory)|go:"GO:0007616"(long-term memory)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010021"(amylopectin biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031550"(positive regulation of brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044381"(glucose import in response to insulin stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046323"(glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0098694"(regulation of synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0098793"(presynapse)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002441("Glucose transporter, type 4 (GLUT4)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-189200|ensembl:ENSRNOG00000017226(gene)|ensembl:ENSRNOT00000023256(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)	interpro:IPR011761(ATP-grasp fold)|interpro:IPR013650(ATP-grasp fold, succinyl-CoA synthetase-type)|interpro:IPR013815(ATP-grasp fold, subdomain 1)|interpro:IPR005811(ATP-citrate lyase/succinyl-CoA ligase)|interpro:IPR017866|interpro:IPR005809(Succinyl-CoA synthetase, beta subunit)|interpro:IPR016102(Succinyl-CoA synthetase-like)|interpro:IPR034722|go:"GO:0004776"("succinate-CoA ligase (GDP-forming) activity")|go:"GO:0005524"(ATP binding)|go:"GO:0005525"(GTP binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0006099"(tricarboxylic acid cycle)|go:"GO:0006104"(succinyl-CoA metabolic process)|go:"GO:0046872"(metal ion binding)	-	-	-	caution:"The participant EBI-349571(P68370) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919386(Q7TP47) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920972(Q5XIP9) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-916419(P11980) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919578(Q8R491) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920554(Q5U3Z7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920647(Q5U2X8) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920585(Q7TP24) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-779677(P05426) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-915744(P02454) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|agonist:Insulin was shown to increase or decrease GLUT4 protein interactions in specific cases.|comment:"Insulin decreased GLUT4 interactions with the following proteins: Q9ER30 (Sarcosin), P09527 (Rab-7), O88960 (N-ethylmaleimide sensitive), P09456 (PKA I regulatory subunit), P27881 (Hexokinase type II), P07872 (Acyl-coenzyme A oxidase), Q6DGF1 (Isocitrate dehydrogenase), Q9EQX9 (Ubiquitin-conjugating), Q63446 (Polyubiquitin), P24268 (Cathepsin D), Q91XW0 (Heat shock protein 86), Q5FVH0 (unknown), P58405 (Striatin 3), Q62667 (Major vault protein), Q66H50 (unknown), Q09167 (splicing factor), Q9JHU5 (Arfaptin 1)."|comment:"Insulin increased GLUT4 interaction with the following proteins:Q9Z1P2 (R-actinin-1), P45592 (Cofilin), Q9QXQ0 (R-actinin-4), P26473 (ADP-ribosylation factor), P26437 (ADP-ribosylation factor),   Q7TNP1 (Basigin 2), Q6P6R2 (Dihydrolipoamide dehydrogenase),   P04797 (GAPDH), Q63081 (Protein disulfide isomerase), P29457 (47 kDa heat shock protein), Q9R1J8 (Leprecan), O88638 (Putative eps protein),   Q64375 (Synaptonemal complex)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:NDPK - Interactions involving proteins containing InterPro domain IPR001564, Nucleoside diphosphate kinase, core.	taxid:10116(rat-l6)|taxid:10116(Rattus norvegicus)	-	2006/02/15	2021/11/30	rogid:PbFY2lfrty8yw40Jq7ShR7xfuV410116	rogid:NoXKNffNGzXabgs/m54z53dygmo10116	intact-crc:44F3A2176D02515F|rigid:9RVm0UBcqQF4k06RGKO89Bg16Q8	false	myc tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P19357	uniprotkb:O70282	intact:EBI-915426|uniprotkb:P97900|ensembl:ENSRNOP00000023256	intact:EBI-915638	psi-mi:glut4_rat(display_long)|uniprotkb:Glucose transporter type 4, insulin-responsive(gene name synonym)|uniprotkb:Slc2a4(gene name)|psi-mi:Slc2a4(display_short)|uniprotkb:Glut4(gene name synonym)	psi-mi:o70282_rat(display_long)|uniprotkb:Alpha-trehalose glucohydrolase(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Foster et al. (2006)	pubmed:16396496|mint:MINT-5218203	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-921030	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2711|refseq:NP_036883.1|refseq:XP_006246658.1|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007611"(learning or memory)|go:"GO:0007614"(short-term memory)|go:"GO:0007616"(long-term memory)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010021"(amylopectin biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031550"(positive regulation of brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044381"(glucose import in response to insulin stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046323"(glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0098694"(regulation of synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0098793"(presynapse)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002441("Glucose transporter, type 4 (GLUT4)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-189200|ensembl:ENSRNOG00000017226(gene)|ensembl:ENSRNOT00000023256(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)	interpro:IPR008928(Six-hairpin glycosidase-like)|interpro:IPR001661(Glycoside hydrolase, family 37)|interpro:IPR018232|interpro:IPR012341(Six-hairpin glycosidase)|go:"GO:0004555"(alpha,alpha-trehalase activity)|go:"GO:0005991"(trehalose metabolic process)	-	-	-	caution:"The participant EBI-349571(P68370) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919386(Q7TP47) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920972(Q5XIP9) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-916419(P11980) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919578(Q8R491) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920554(Q5U3Z7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920647(Q5U2X8) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920585(Q7TP24) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-779677(P05426) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-915744(P02454) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|agonist:Insulin was shown to increase or decrease GLUT4 protein interactions in specific cases.|comment:"Insulin decreased GLUT4 interactions with the following proteins: Q9ER30 (Sarcosin), P09527 (Rab-7), O88960 (N-ethylmaleimide sensitive), P09456 (PKA I regulatory subunit), P27881 (Hexokinase type II), P07872 (Acyl-coenzyme A oxidase), Q6DGF1 (Isocitrate dehydrogenase), Q9EQX9 (Ubiquitin-conjugating), Q63446 (Polyubiquitin), P24268 (Cathepsin D), Q91XW0 (Heat shock protein 86), Q5FVH0 (unknown), P58405 (Striatin 3), Q62667 (Major vault protein), Q66H50 (unknown), Q09167 (splicing factor), Q9JHU5 (Arfaptin 1)."|comment:"Insulin increased GLUT4 interaction with the following proteins:Q9Z1P2 (R-actinin-1), P45592 (Cofilin), Q9QXQ0 (R-actinin-4), P26473 (ADP-ribosylation factor), P26437 (ADP-ribosylation factor),   Q7TNP1 (Basigin 2), Q6P6R2 (Dihydrolipoamide dehydrogenase),   P04797 (GAPDH), Q63081 (Protein disulfide isomerase), P29457 (47 kDa heat shock protein), Q9R1J8 (Leprecan), O88638 (Putative eps protein),   Q64375 (Synaptonemal complex)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:NDPK - Interactions involving proteins containing InterPro domain IPR001564, Nucleoside diphosphate kinase, core.	taxid:10116(rat-l6)|taxid:10116(Rattus norvegicus)	-	2006/02/15	2021/11/30	rogid:PbFY2lfrty8yw40Jq7ShR7xfuV410116	rogid:XRbn3HseIG3WRgzHCT1G0e0OzwY10116	intact-crc:44F3A2176D02515F|rigid:9RVm0UBcqQF4k06RGKO89Bg16Q8	false	myc tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P19357	uniprotkb:P29266	intact:EBI-915426|uniprotkb:P97900|ensembl:ENSRNOP00000023256	intact:EBI-917114|uniprotkb:A1L107|ensembl:ENSRNOP00000011069	psi-mi:glut4_rat(display_long)|uniprotkb:Glucose transporter type 4, insulin-responsive(gene name synonym)|uniprotkb:Slc2a4(gene name)|psi-mi:Slc2a4(display_short)|uniprotkb:Glut4(gene name synonym)	psi-mi:3hidh_rat(display_long)|uniprotkb:Hibadh(gene name)|psi-mi:Hibadh(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Foster et al. (2006)	pubmed:16396496|mint:MINT-5218203	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-921030	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2711|refseq:NP_036883.1|refseq:XP_006246658.1|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007611"(learning or memory)|go:"GO:0007614"(short-term memory)|go:"GO:0007616"(long-term memory)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010021"(amylopectin biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031550"(positive regulation of brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044381"(glucose import in response to insulin stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046323"(glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0098694"(regulation of synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0098793"(presynapse)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002441("Glucose transporter, type 4 (GLUT4)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-189200|ensembl:ENSRNOG00000017226(gene)|ensembl:ENSRNOT00000023256(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)	rgd:708399|refseq:NP_071579.1|go:"GO:0016616"(oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor)|go:"GO:0050661"(NADP binding)|go:"GO:0051287"(NAD binding)|interpro:IPR002204(3-hydroxyisobutyrate dehydrogenase-related, conserved site)|interpro:IPR006115(6-phosphogluconate dehydrogenase, NAD-binding)|interpro:IPR008927(6-phosphogluconate dehydrogenase, C-terminal-like)|interpro:IPR011548(3-hydroxyisobutyrate dehydrogenase)|interpro:IPR013328(Dehydrogenase, multihelical)|interpro:IPR015815(3-hydroxyacid dehydrogenase/reductase)|interpro:IPR029154|interpro:IPR036291|reactome:R-RNO-70895|ensembl:ENSRNOG00000008063(gene)|ensembl:ENSRNOT00000011069(transcript)|go:"GO:0005739"(mitochondrion)|go:"GO:0006574"(valine catabolic process)|go:"GO:0008442"(3-hydroxyisobutyrate dehydrogenase activity)|go:"GO:0009083"(branched-chain amino acid catabolic process)	-	-	-	caution:"The participant EBI-349571(P68370) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919386(Q7TP47) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920972(Q5XIP9) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-916419(P11980) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919578(Q8R491) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920554(Q5U3Z7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920647(Q5U2X8) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920585(Q7TP24) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-779677(P05426) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-915744(P02454) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|agonist:Insulin was shown to increase or decrease GLUT4 protein interactions in specific cases.|comment:"Insulin decreased GLUT4 interactions with the following proteins: Q9ER30 (Sarcosin), P09527 (Rab-7), O88960 (N-ethylmaleimide sensitive), P09456 (PKA I regulatory subunit), P27881 (Hexokinase type II), P07872 (Acyl-coenzyme A oxidase), Q6DGF1 (Isocitrate dehydrogenase), Q9EQX9 (Ubiquitin-conjugating), Q63446 (Polyubiquitin), P24268 (Cathepsin D), Q91XW0 (Heat shock protein 86), Q5FVH0 (unknown), P58405 (Striatin 3), Q62667 (Major vault protein), Q66H50 (unknown), Q09167 (splicing factor), Q9JHU5 (Arfaptin 1)."|comment:"Insulin increased GLUT4 interaction with the following proteins:Q9Z1P2 (R-actinin-1), P45592 (Cofilin), Q9QXQ0 (R-actinin-4), P26473 (ADP-ribosylation factor), P26437 (ADP-ribosylation factor),   Q7TNP1 (Basigin 2), Q6P6R2 (Dihydrolipoamide dehydrogenase),   P04797 (GAPDH), Q63081 (Protein disulfide isomerase), P29457 (47 kDa heat shock protein), Q9R1J8 (Leprecan), O88638 (Putative eps protein),   Q64375 (Synaptonemal complex)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:NDPK - Interactions involving proteins containing InterPro domain IPR001564, Nucleoside diphosphate kinase, core.	taxid:10116(rat-l6)|taxid:10116(Rattus norvegicus)	-	2006/02/15	2021/11/30	rogid:PbFY2lfrty8yw40Jq7ShR7xfuV410116	rogid:t4ekflmolmGS62N/6OmTPTBHHRg10116	intact-crc:44F3A2176D02515F|rigid:9RVm0UBcqQF4k06RGKO89Bg16Q8	false	myc tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P19357	uniprotkb:P28480	intact:EBI-915426|uniprotkb:P97900|ensembl:ENSRNOP00000023256	intact:EBI-917100|ensembl:ENSRNOP00000019531	psi-mi:glut4_rat(display_long)|uniprotkb:Glucose transporter type 4, insulin-responsive(gene name synonym)|uniprotkb:Slc2a4(gene name)|psi-mi:Slc2a4(display_short)|uniprotkb:Glut4(gene name synonym)	psi-mi:tcpa_rat(display_long)|uniprotkb:CCT-alpha(gene name synonym)|uniprotkb:Tcp1(gene name)|psi-mi:Tcp1(display_short)|uniprotkb:Ccta(gene name synonym)|uniprotkb:Cct1(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Foster et al. (2006)	pubmed:16396496|mint:MINT-5218203	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-921030	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2711|refseq:NP_036883.1|refseq:XP_006246658.1|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007611"(learning or memory)|go:"GO:0007614"(short-term memory)|go:"GO:0007616"(long-term memory)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010021"(amylopectin biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031550"(positive regulation of brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044381"(glucose import in response to insulin stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046323"(glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0098694"(regulation of synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0098793"(presynapse)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002441("Glucose transporter, type 4 (GLUT4)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-189200|ensembl:ENSRNOG00000017226(gene)|ensembl:ENSRNOT00000023256(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)	rgd:3832|refseq:NP_036802.1|ensembl:ENSRNOG00000014160(gene)|ensembl:ENSRNOT00000019531(transcript)|go:"GO:0000242"(pericentriolar material)|go:"GO:0000792"(heterochromatin)|go:"GO:0001669"(acrosomal vesicle)|go:"GO:0002199"(zona pellucida receptor complex)|go:"GO:0005524"(ATP binding)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005813"(centrosome)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0005832"(chaperonin-containing T-complex)|go:"GO:0005874"(microtubule)|go:"GO:0006457"(protein folding)|go:"GO:0007286"(spermatid development)|go:"GO:0007339"(binding of sperm to zona pellucida)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032212"(positive regulation of telomere maintenance via telomerase)|go:"GO:0044053"(translocation of peptides or proteins into host cell cytoplasm)|go:"GO:0044183"(protein folding chaperone)|go:"GO:0044297"(cell body)|go:"GO:0050821"(protein stabilization)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051973"(positive regulation of telomerase activity)|go:"GO:0090666"(scaRNA localization to Cajal body)|go:"GO:1901998"(toxin transport)|go:"GO:1904851"(positive regulation of establishment of protein localization to telomere)|go:"GO:1904874"(positive regulation of telomerase RNA localization to Cajal body)|go:"GO:2000109"(regulation of macrophage apoptotic process)|interpro:IPR002194(Chaperonin TCP-1, conserved site)|interpro:IPR002423(Chaperonin Cpn60/TCP-1)|interpro:IPR012715(T-complex protein 1, alpha subunit)|interpro:IPR017998|interpro:IPR027409|interpro:IPR027410|interpro:IPR027413|mint:P28480|reactome:R-RNO-390471|reactome:R-RNO-5620922|reactome:R-RNO-6814122	-	-	-	caution:"The participant EBI-349571(P68370) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919386(Q7TP47) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920972(Q5XIP9) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-916419(P11980) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919578(Q8R491) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920554(Q5U3Z7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920647(Q5U2X8) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920585(Q7TP24) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-779677(P05426) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-915744(P02454) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|agonist:Insulin was shown to increase or decrease GLUT4 protein interactions in specific cases.|comment:"Insulin decreased GLUT4 interactions with the following proteins: Q9ER30 (Sarcosin), P09527 (Rab-7), O88960 (N-ethylmaleimide sensitive), P09456 (PKA I regulatory subunit), P27881 (Hexokinase type II), P07872 (Acyl-coenzyme A oxidase), Q6DGF1 (Isocitrate dehydrogenase), Q9EQX9 (Ubiquitin-conjugating), Q63446 (Polyubiquitin), P24268 (Cathepsin D), Q91XW0 (Heat shock protein 86), Q5FVH0 (unknown), P58405 (Striatin 3), Q62667 (Major vault protein), Q66H50 (unknown), Q09167 (splicing factor), Q9JHU5 (Arfaptin 1)."|comment:"Insulin increased GLUT4 interaction with the following proteins:Q9Z1P2 (R-actinin-1), P45592 (Cofilin), Q9QXQ0 (R-actinin-4), P26473 (ADP-ribosylation factor), P26437 (ADP-ribosylation factor),   Q7TNP1 (Basigin 2), Q6P6R2 (Dihydrolipoamide dehydrogenase),   P04797 (GAPDH), Q63081 (Protein disulfide isomerase), P29457 (47 kDa heat shock protein), Q9R1J8 (Leprecan), O88638 (Putative eps protein),   Q64375 (Synaptonemal complex)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:NDPK - Interactions involving proteins containing InterPro domain IPR001564, Nucleoside diphosphate kinase, core.	taxid:10116(rat-l6)|taxid:10116(Rattus norvegicus)	-	2006/02/15	2021/11/30	rogid:PbFY2lfrty8yw40Jq7ShR7xfuV410116	rogid:DMkEAZJ7fSji7MjRVOLDtef1bB010116	intact-crc:44F3A2176D02515F|rigid:9RVm0UBcqQF4k06RGKO89Bg16Q8	false	myc tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P19357	uniprotkb:P28075	intact:EBI-915426|uniprotkb:P97900|ensembl:ENSRNOP00000023256	intact:EBI-917094	psi-mi:glut4_rat(display_long)|uniprotkb:Glucose transporter type 4, insulin-responsive(gene name synonym)|uniprotkb:Slc2a4(gene name)|psi-mi:Slc2a4(display_short)|uniprotkb:Glut4(gene name synonym)	psi-mi:psb5_rat(display_long)|uniprotkb:Proteasome epsilon chain(gene name synonym)|uniprotkb:Macropain epsilon chain(gene name synonym)|uniprotkb:Multicatalytic endopeptidase complex epsilon chain(gene name synonym)|uniprotkb:Proteasome subunit X(gene name synonym)|uniprotkb:Proteasome chain 6(gene name synonym)|uniprotkb:Psmb5(gene name)|psi-mi:Psmb5(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Foster et al. (2006)	pubmed:16396496|mint:MINT-5218203	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-921030	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2711|refseq:NP_036883.1|refseq:XP_006246658.1|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007611"(learning or memory)|go:"GO:0007614"(short-term memory)|go:"GO:0007616"(long-term memory)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010021"(amylopectin biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031550"(positive regulation of brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044381"(glucose import in response to insulin stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046323"(glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0098694"(regulation of synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0098793"(presynapse)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002441("Glucose transporter, type 4 (GLUT4)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-189200|ensembl:ENSRNOG00000017226(gene)|ensembl:ENSRNOT00000023256(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)	rgd:61879|interpro:IPR000243(Peptidase T1A, proteasome beta-subunit)|interpro:IPR016050(Proteasome, beta-type subunit, conserved site)|interpro:IPR001353(20S proteasome, A and B subunits)|interpro:IPR023333|interpro:IPR029055|reactome:R-RNO-8932339|interpro:IPR037558|rcsb pdb:6EPC|rcsb pdb:6EPD|rcsb pdb:6EPE|rcsb pdb:6EPF|reactome:R-RNO-174084|reactome:R-RNO-5689603|reactome:R-RNO-5689880|reactome:R-RNO-68827|reactome:R-RNO-8951664|rcsb pdb:6TU3|reactome:R-RNO-1169091|reactome:R-RNO-1234176|reactome:R-RNO-1236978|reactome:R-RNO-174154|reactome:R-RNO-174178|reactome:R-RNO-174184|reactome:R-RNO-187577|reactome:R-RNO-195253|reactome:R-RNO-2467813|reactome:R-RNO-349425|reactome:R-RNO-350562|reactome:R-RNO-382556|reactome:R-RNO-450408|reactome:R-RNO-4608870|reactome:R-RNO-4641257|reactome:R-RNO-4641258|reactome:R-RNO-5358346|reactome:R-RNO-5607761|reactome:R-RNO-5610780|reactome:R-RNO-5610785|reactome:R-RNO-5632684|reactome:R-RNO-5658442|reactome:R-RNO-5668541|reactome:R-RNO-5676590|reactome:R-RNO-5687128|reactome:R-RNO-68949|reactome:R-RNO-69017|reactome:R-RNO-69481|reactome:R-RNO-69601|reactome:R-RNO-75815|reactome:R-RNO-8852276|reactome:R-RNO-8854050|reactome:R-RNO-8939236|reactome:R-RNO-8941858|reactome:R-RNO-8948751|reactome:R-RNO-983168|refseq:NP_001099197.2|go:"GO:0000502"(proteasome complex)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004298"(threonine-type endopeptidase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005839"(proteasome core complex)|go:"GO:0006508"(proteolysis)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0008233"(peptidase activity)|go:"GO:0010499"(proteasomal ubiquitin-independent protein catabolic process)|go:"GO:0019774"(proteasome core complex, beta-subunit complex)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)	-	-	-	caution:"The participant EBI-349571(P68370) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919386(Q7TP47) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920972(Q5XIP9) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-916419(P11980) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919578(Q8R491) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920554(Q5U3Z7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920647(Q5U2X8) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920585(Q7TP24) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-779677(P05426) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-915744(P02454) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|agonist:Insulin was shown to increase or decrease GLUT4 protein interactions in specific cases.|comment:"Insulin decreased GLUT4 interactions with the following proteins: Q9ER30 (Sarcosin), P09527 (Rab-7), O88960 (N-ethylmaleimide sensitive), P09456 (PKA I regulatory subunit), P27881 (Hexokinase type II), P07872 (Acyl-coenzyme A oxidase), Q6DGF1 (Isocitrate dehydrogenase), Q9EQX9 (Ubiquitin-conjugating), Q63446 (Polyubiquitin), P24268 (Cathepsin D), Q91XW0 (Heat shock protein 86), Q5FVH0 (unknown), P58405 (Striatin 3), Q62667 (Major vault protein), Q66H50 (unknown), Q09167 (splicing factor), Q9JHU5 (Arfaptin 1)."|comment:"Insulin increased GLUT4 interaction with the following proteins:Q9Z1P2 (R-actinin-1), P45592 (Cofilin), Q9QXQ0 (R-actinin-4), P26473 (ADP-ribosylation factor), P26437 (ADP-ribosylation factor),   Q7TNP1 (Basigin 2), Q6P6R2 (Dihydrolipoamide dehydrogenase),   P04797 (GAPDH), Q63081 (Protein disulfide isomerase), P29457 (47 kDa heat shock protein), Q9R1J8 (Leprecan), O88638 (Putative eps protein),   Q64375 (Synaptonemal complex)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:NDPK - Interactions involving proteins containing InterPro domain IPR001564, Nucleoside diphosphate kinase, core.	taxid:10116(rat-l6)|taxid:10116(Rattus norvegicus)	-	2006/02/15	2021/11/30	rogid:PbFY2lfrty8yw40Jq7ShR7xfuV410116	rogid:Slz9vkbYf5wXvbBlILYjFts3qSo10116	intact-crc:44F3A2176D02515F|rigid:9RVm0UBcqQF4k06RGKO89Bg16Q8	false	myc tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P19357	uniprotkb:P28042	intact:EBI-915426|uniprotkb:P97900|ensembl:ENSRNOP00000023256	intact:EBI-917082	psi-mi:glut4_rat(display_long)|uniprotkb:Glucose transporter type 4, insulin-responsive(gene name synonym)|uniprotkb:Slc2a4(gene name)|psi-mi:Slc2a4(display_short)|uniprotkb:Glut4(gene name synonym)	psi-mi:ssbp_rat(display_long)|uniprotkb:Single strand DNA-binding protein P16(gene name synonym)|uniprotkb:Ssbp1(gene name)|psi-mi:Ssbp1(display_short)|uniprotkb:Ssbp(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Foster et al. (2006)	pubmed:16396496|mint:MINT-5218203	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-921030	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2711|refseq:NP_036883.1|refseq:XP_006246658.1|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007611"(learning or memory)|go:"GO:0007614"(short-term memory)|go:"GO:0007616"(long-term memory)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010021"(amylopectin biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031550"(positive regulation of brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044381"(glucose import in response to insulin stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046323"(glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0098694"(regulation of synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0098793"(presynapse)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002441("Glucose transporter, type 4 (GLUT4)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-189200|ensembl:ENSRNOG00000017226(gene)|ensembl:ENSRNOT00000023256(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)	rgd:3760|interpro:IPR012340(Nucleic acid-binding, OB-fold)|interpro:IPR000424(Primosome PriB/single-strand DNA-binding)|interpro:IPR011344(Single-strand DNA-binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0006264"(mitochondrial DNA replication)|go:"GO:0006268"(DNA unwinding involved in DNA replication)|go:"GO:0009295"(nucleoid)|go:"GO:0042645"(mitochondrial nucleoid)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0051096"(positive regulation of helicase activity)|go:"GO:0051289"(protein homotetramerization)|go:"GO:0070584"(mitochondrion morphogenesis)|go:"GO:0090297"(positive regulation of mitochondrial DNA replication)|go:"GO:1905776"(positive regulation of DNA helicase activity)	-	-	-	caution:"The participant EBI-349571(P68370) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919386(Q7TP47) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920972(Q5XIP9) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-916419(P11980) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919578(Q8R491) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920554(Q5U3Z7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920647(Q5U2X8) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920585(Q7TP24) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-779677(P05426) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-915744(P02454) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|agonist:Insulin was shown to increase or decrease GLUT4 protein interactions in specific cases.|comment:"Insulin decreased GLUT4 interactions with the following proteins: Q9ER30 (Sarcosin), P09527 (Rab-7), O88960 (N-ethylmaleimide sensitive), P09456 (PKA I regulatory subunit), P27881 (Hexokinase type II), P07872 (Acyl-coenzyme A oxidase), Q6DGF1 (Isocitrate dehydrogenase), Q9EQX9 (Ubiquitin-conjugating), Q63446 (Polyubiquitin), P24268 (Cathepsin D), Q91XW0 (Heat shock protein 86), Q5FVH0 (unknown), P58405 (Striatin 3), Q62667 (Major vault protein), Q66H50 (unknown), Q09167 (splicing factor), Q9JHU5 (Arfaptin 1)."|comment:"Insulin increased GLUT4 interaction with the following proteins:Q9Z1P2 (R-actinin-1), P45592 (Cofilin), Q9QXQ0 (R-actinin-4), P26473 (ADP-ribosylation factor), P26437 (ADP-ribosylation factor),   Q7TNP1 (Basigin 2), Q6P6R2 (Dihydrolipoamide dehydrogenase),   P04797 (GAPDH), Q63081 (Protein disulfide isomerase), P29457 (47 kDa heat shock protein), Q9R1J8 (Leprecan), O88638 (Putative eps protein),   Q64375 (Synaptonemal complex)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:NDPK - Interactions involving proteins containing InterPro domain IPR001564, Nucleoside diphosphate kinase, core.	taxid:10116(rat-l6)|taxid:10116(Rattus norvegicus)	-	2006/02/15	2021/11/30	rogid:PbFY2lfrty8yw40Jq7ShR7xfuV410116	rogid:HemtwpgmRCZCYe4Mv+Lq4WLAIXs10116	intact-crc:44F3A2176D02515F|rigid:9RVm0UBcqQF4k06RGKO89Bg16Q8	false	myc tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P19357	uniprotkb:P27952	intact:EBI-915426|uniprotkb:P97900|ensembl:ENSRNOP00000023256	intact:EBI-917074|uniprotkb:Q4G062|ensembl:ENSRNOP00000019508	psi-mi:glut4_rat(display_long)|uniprotkb:Glucose transporter type 4, insulin-responsive(gene name synonym)|uniprotkb:Slc2a4(gene name)|psi-mi:Slc2a4(display_short)|uniprotkb:Glut4(gene name synonym)	psi-mi:rs2_rat(display_long)|uniprotkb:Rps2(gene name)|psi-mi:Rps2(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Foster et al. (2006)	pubmed:16396496|mint:MINT-5218203	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-921030	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2711|refseq:NP_036883.1|refseq:XP_006246658.1|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007611"(learning or memory)|go:"GO:0007614"(short-term memory)|go:"GO:0007616"(long-term memory)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010021"(amylopectin biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031550"(positive regulation of brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044381"(glucose import in response to insulin stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046323"(glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0098694"(regulation of synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0098793"(presynapse)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002441("Glucose transporter, type 4 (GLUT4)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-189200|ensembl:ENSRNOG00000017226(gene)|ensembl:ENSRNOT00000023256(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)	rgd:619887|refseq:NP_114026.3|ensembl:ENSRNOG00000014179(gene)|ensembl:ENSRNOT00000019508(transcript)|go:"GO:0000028"(ribosomal small subunit assembly)|go:"GO:0001731"(formation of translation preinitiation complex)|go:"GO:0003729"(mRNA binding)|go:"GO:0003735"(structural constituent of ribosome)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006412"(translation)|go:"GO:0017134"(fibroblast growth factor binding)|go:"GO:0019899"(enzyme binding)|go:"GO:0022626"(cytosolic ribosome)|go:"GO:0022627"(cytosolic small ribosomal subunit)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045471"(response to ethanol)|go:"GO:0051443"(positive regulation of ubiquitin-protein transferase activity)|go:"GO:0071353"(cellular response to interleukin-4)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR000851(Ribosomal protein S5)|interpro:IPR005324(Ribosomal protein S5, C-terminal)|interpro:IPR005711(Ribosomal protein S5, eukaryotic/archaeal)|interpro:IPR013810(Ribosomal protein S5, N-terminal)|interpro:IPR014721(Ribosomal protein S5 domain 2-type fold)|interpro:IPR018192|interpro:IPR020568	-	-	-	caution:"The participant EBI-349571(P68370) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919386(Q7TP47) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920972(Q5XIP9) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-916419(P11980) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919578(Q8R491) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920554(Q5U3Z7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920647(Q5U2X8) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920585(Q7TP24) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-779677(P05426) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-915744(P02454) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|agonist:Insulin was shown to increase or decrease GLUT4 protein interactions in specific cases.|comment:"Insulin decreased GLUT4 interactions with the following proteins: Q9ER30 (Sarcosin), P09527 (Rab-7), O88960 (N-ethylmaleimide sensitive), P09456 (PKA I regulatory subunit), P27881 (Hexokinase type II), P07872 (Acyl-coenzyme A oxidase), Q6DGF1 (Isocitrate dehydrogenase), Q9EQX9 (Ubiquitin-conjugating), Q63446 (Polyubiquitin), P24268 (Cathepsin D), Q91XW0 (Heat shock protein 86), Q5FVH0 (unknown), P58405 (Striatin 3), Q62667 (Major vault protein), Q66H50 (unknown), Q09167 (splicing factor), Q9JHU5 (Arfaptin 1)."|comment:"Insulin increased GLUT4 interaction with the following proteins:Q9Z1P2 (R-actinin-1), P45592 (Cofilin), Q9QXQ0 (R-actinin-4), P26473 (ADP-ribosylation factor), P26437 (ADP-ribosylation factor),   Q7TNP1 (Basigin 2), Q6P6R2 (Dihydrolipoamide dehydrogenase),   P04797 (GAPDH), Q63081 (Protein disulfide isomerase), P29457 (47 kDa heat shock protein), Q9R1J8 (Leprecan), O88638 (Putative eps protein),   Q64375 (Synaptonemal complex)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:NDPK - Interactions involving proteins containing InterPro domain IPR001564, Nucleoside diphosphate kinase, core.	taxid:10116(rat-l6)|taxid:10116(Rattus norvegicus)	-	2006/02/15	2021/11/30	rogid:PbFY2lfrty8yw40Jq7ShR7xfuV410116	rogid:VO9MH9FtET3oSV8lwWxbdf680qg10116	intact-crc:44F3A2176D02515F|rigid:9RVm0UBcqQF4k06RGKO89Bg16Q8	false	myc tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P19357	uniprotkb:P27881	intact:EBI-915426|uniprotkb:P97900|ensembl:ENSRNOP00000023256	intact:EBI-917066|uniprotkb:Q9QWR1|ensembl:ENSRNOP00000008813	psi-mi:glut4_rat(display_long)|uniprotkb:Glucose transporter type 4, insulin-responsive(gene name synonym)|uniprotkb:Slc2a4(gene name)|psi-mi:Slc2a4(display_short)|uniprotkb:Glut4(gene name synonym)	psi-mi:hxk2_rat(display_long)|uniprotkb:Hexokinase type II(gene name synonym)|uniprotkb:Hk2(gene name)|psi-mi:Hk2(display_short)|uniprotkb:Hexokinase-B(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Foster et al. (2006)	pubmed:16396496|mint:MINT-5218203	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-921030	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2711|refseq:NP_036883.1|refseq:XP_006246658.1|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007611"(learning or memory)|go:"GO:0007614"(short-term memory)|go:"GO:0007616"(long-term memory)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010021"(amylopectin biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031550"(positive regulation of brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044381"(glucose import in response to insulin stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046323"(glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0098694"(regulation of synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0098793"(presynapse)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002441("Glucose transporter, type 4 (GLUT4)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-189200|ensembl:ENSRNOG00000017226(gene)|ensembl:ENSRNOT00000023256(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)	rgd:2797|refseq:NP_036867.1|dip:DIP-37314N|ensembl:ENSRNOG00000006116(gene)|ensembl:ENSRNOT00000008813(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001678"(cellular glucose homeostasis)|go:"GO:0002931"(response to ischemia)|go:"GO:0004340"(glucokinase activity)|go:"GO:0004396"(hexokinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005536"(glucose binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006002"(fructose 6-phosphate metabolic process)|go:"GO:0006006"(glucose metabolic process)|go:"GO:0006007"(glucose catabolic process)|go:"GO:0006096"(glycolytic process)|go:"GO:0007595"(lactation)|go:"GO:0008637"(apoptotic mitochondrial changes)|go:"GO:0008865"(fructokinase activity)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0019158"(mannokinase activity)|go:"GO:0035795"(negative regulation of mitochondrial membrane permeability)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0046324"(regulation of glucose import)|go:"GO:0046835"(carbohydrate phosphorylation)|go:"GO:0051156"(glucose 6-phosphate metabolic process)|go:"GO:0072655"(establishment of protein localization to mitochondrion)|go:"GO:0072656"(maintenance of protein location in mitochondrion)|go:"GO:1904925"(positive regulation of autophagy of mitochondrion in response to mitochondrial depolarization)|go:"GO:1990830"(cellular response to leukemia inhibitory factor)|go:"GO:2000378"(negative regulation of reactive oxygen species metabolic process)|interpro:IPR001312(Hexokinase)|interpro:IPR019807|interpro:IPR022672|interpro:IPR022673|interpro:IPR043129|reactome:R-RNO-70171	-	-	-	caution:"The participant EBI-349571(P68370) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919386(Q7TP47) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920972(Q5XIP9) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-916419(P11980) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919578(Q8R491) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920554(Q5U3Z7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920647(Q5U2X8) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920585(Q7TP24) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-779677(P05426) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-915744(P02454) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|agonist:Insulin was shown to increase or decrease GLUT4 protein interactions in specific cases.|comment:"Insulin decreased GLUT4 interactions with the following proteins: Q9ER30 (Sarcosin), P09527 (Rab-7), O88960 (N-ethylmaleimide sensitive), P09456 (PKA I regulatory subunit), P27881 (Hexokinase type II), P07872 (Acyl-coenzyme A oxidase), Q6DGF1 (Isocitrate dehydrogenase), Q9EQX9 (Ubiquitin-conjugating), Q63446 (Polyubiquitin), P24268 (Cathepsin D), Q91XW0 (Heat shock protein 86), Q5FVH0 (unknown), P58405 (Striatin 3), Q62667 (Major vault protein), Q66H50 (unknown), Q09167 (splicing factor), Q9JHU5 (Arfaptin 1)."|comment:"Insulin increased GLUT4 interaction with the following proteins:Q9Z1P2 (R-actinin-1), P45592 (Cofilin), Q9QXQ0 (R-actinin-4), P26473 (ADP-ribosylation factor), P26437 (ADP-ribosylation factor),   Q7TNP1 (Basigin 2), Q6P6R2 (Dihydrolipoamide dehydrogenase),   P04797 (GAPDH), Q63081 (Protein disulfide isomerase), P29457 (47 kDa heat shock protein), Q9R1J8 (Leprecan), O88638 (Putative eps protein),   Q64375 (Synaptonemal complex)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:NDPK - Interactions involving proteins containing InterPro domain IPR001564, Nucleoside diphosphate kinase, core.	taxid:10116(rat-l6)|taxid:10116(Rattus norvegicus)	-	2006/02/15	2021/11/30	rogid:PbFY2lfrty8yw40Jq7ShR7xfuV410116	rogid:heFwA0Zlqz0IxAHviY2VHIuAYRI10116	intact-crc:44F3A2176D02515F|rigid:9RVm0UBcqQF4k06RGKO89Bg16Q8	false	myc tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P19357	uniprotkb:P62961	intact:EBI-915426|uniprotkb:P97900|ensembl:ENSRNOP00000023256	intact:EBI-917053|uniprotkb:P22568|uniprotkb:P27817|uniprotkb:P43482|uniprotkb:Q4KMA4	psi-mi:glut4_rat(display_long)|uniprotkb:Glucose transporter type 4, insulin-responsive(gene name synonym)|uniprotkb:Slc2a4(gene name)|psi-mi:Slc2a4(display_short)|uniprotkb:Glut4(gene name synonym)	psi-mi:ybox1_rat(display_long)|uniprotkb:Nuclease-sensitive element-binding protein 1(gene name synonym)|uniprotkb:Y-box transcription factor(gene name synonym)|uniprotkb:Enhancer factor I subunit A(gene name synonym)|uniprotkb:Ybx1(gene name)|psi-mi:Ybx1(display_short)|uniprotkb:Yb1(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Foster et al. (2006)	pubmed:16396496|mint:MINT-5218203	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-921030	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2711|refseq:NP_036883.1|refseq:XP_006246658.1|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007611"(learning or memory)|go:"GO:0007614"(short-term memory)|go:"GO:0007616"(long-term memory)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010021"(amylopectin biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031550"(positive regulation of brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044381"(glucose import in response to insulin stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046323"(glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0098694"(regulation of synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0098793"(presynapse)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002441("Glucose transporter, type 4 (GLUT4)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-189200|ensembl:ENSRNOG00000017226(gene)|ensembl:ENSRNOT00000023256(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)	rgd:61843|refseq:NP_113751.3|interpro:IPR019844|interpro:IPR011129(Cold shock protein)|interpro:IPR002059(Cold-shock protein, DNA-binding)|interpro:IPR012340(Nucleic acid-binding, OB-fold)|reactome:R-RNO-72163|reactome:R-RNO-72165|reactome:R-RNO-9017802|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0002039"(p53 binding)|go:"GO:0003676"(nucleic acid binding)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005689"(U12-type spliceosomal complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006397"(mRNA processing)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008380"(RNA splicing)|go:"GO:0008544"(epidermis development)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0030425"(dendrite)|go:"GO:0035198"(miRNA binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046627"(negative regulation of insulin receptor signaling pathway)|go:"GO:0048255"(mRNA stabilization)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048598"(embryonic morphogenesis)|go:"GO:0050658"(RNA transport)|go:"GO:0051020"(GTPase binding)|go:"GO:0051031"(tRNA transport)|go:"GO:0051781"(positive regulation of cell division)|go:"GO:0062153"(C5-methylcytidine-containing RNA binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070934"(CRD-mediated mRNA stabilization)|go:"GO:0070937"(CRD-mediated mRNA stability complex)|go:"GO:0071204"(histone pre-mRNA 3'end processing complex)|go:"GO:1903608"(protein localization to cytoplasmic stress granule)|go:"GO:1990124"(messenger ribonucleoprotein complex)|go:"GO:1990428"(miRNA transport)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:1990904"(ribonucleoprotein complex)|go:"GO:2000773"(negative regulation of cellular senescence)	-	-	-	caution:"The participant EBI-349571(P68370) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919386(Q7TP47) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920972(Q5XIP9) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-916419(P11980) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919578(Q8R491) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920554(Q5U3Z7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920647(Q5U2X8) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920585(Q7TP24) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-779677(P05426) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-915744(P02454) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|agonist:Insulin was shown to increase or decrease GLUT4 protein interactions in specific cases.|comment:"Insulin decreased GLUT4 interactions with the following proteins: Q9ER30 (Sarcosin), P09527 (Rab-7), O88960 (N-ethylmaleimide sensitive), P09456 (PKA I regulatory subunit), P27881 (Hexokinase type II), P07872 (Acyl-coenzyme A oxidase), Q6DGF1 (Isocitrate dehydrogenase), Q9EQX9 (Ubiquitin-conjugating), Q63446 (Polyubiquitin), P24268 (Cathepsin D), Q91XW0 (Heat shock protein 86), Q5FVH0 (unknown), P58405 (Striatin 3), Q62667 (Major vault protein), Q66H50 (unknown), Q09167 (splicing factor), Q9JHU5 (Arfaptin 1)."|comment:"Insulin increased GLUT4 interaction with the following proteins:Q9Z1P2 (R-actinin-1), P45592 (Cofilin), Q9QXQ0 (R-actinin-4), P26473 (ADP-ribosylation factor), P26437 (ADP-ribosylation factor),   Q7TNP1 (Basigin 2), Q6P6R2 (Dihydrolipoamide dehydrogenase),   P04797 (GAPDH), Q63081 (Protein disulfide isomerase), P29457 (47 kDa heat shock protein), Q9R1J8 (Leprecan), O88638 (Putative eps protein),   Q64375 (Synaptonemal complex)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:NDPK - Interactions involving proteins containing InterPro domain IPR001564, Nucleoside diphosphate kinase, core.	taxid:10116(rat-l6)|taxid:10116(Rattus norvegicus)	-	2006/02/15	2021/11/30	rogid:PbFY2lfrty8yw40Jq7ShR7xfuV410116	rogid:imkViHICtFj/0wQ8IDprza1b43010116	intact-crc:44F3A2176D02515F|rigid:9RVm0UBcqQF4k06RGKO89Bg16Q8	false	myc tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P19357	uniprotkb:P27791	intact:EBI-915426|uniprotkb:P97900|ensembl:ENSRNOP00000023256	intact:EBI-917032|uniprotkb:Q6UA68	psi-mi:glut4_rat(display_long)|uniprotkb:Glucose transporter type 4, insulin-responsive(gene name synonym)|uniprotkb:Slc2a4(gene name)|psi-mi:Slc2a4(display_short)|uniprotkb:Glut4(gene name synonym)	psi-mi:kapca_rat(display_long)|uniprotkb:Prkaca(gene name)|psi-mi:Prkaca(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Foster et al. (2006)	pubmed:16396496|mint:MINT-5218203	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-921030	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2711|refseq:NP_036883.1|refseq:XP_006246658.1|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007611"(learning or memory)|go:"GO:0007614"(short-term memory)|go:"GO:0007616"(long-term memory)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010021"(amylopectin biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031550"(positive regulation of brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044381"(glucose import in response to insulin stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046323"(glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0098694"(regulation of synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0098793"(presynapse)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002441("Glucose transporter, type 4 (GLUT4)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-189200|ensembl:ENSRNOG00000017226(gene)|ensembl:ENSRNOT00000023256(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)	rgd:3389|mint:P27791|dip:DIP-37312N|go:"GO:0000287"(magnesium ion binding)|go:"GO:0001669"(acrosomal vesicle)|go:"GO:0001707"(mesoderm formation)|go:"GO:0001843"(neural tube closure)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004679"(AMP-activated protein kinase activity)|go:"GO:0004691"(cAMP-dependent protein kinase activity)|go:"GO:0004712"(protein serine/threonine/tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005952"(cAMP-dependent protein kinase complex)|go:"GO:0006397"(mRNA processing)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0010737"(protein kinase A signaling)|go:"GO:0016020"(membrane)|go:"GO:0016607"(nuclear speck)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030145"(manganese ion binding)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034237"(protein kinase A regulatory subunit binding)|go:"GO:0034605"(cellular response to heat)|go:"GO:0036126"(sperm flagellum)|go:"GO:0042747"(circadian sleep/wake cycle, REM sleep)|go:"GO:0043005"(neuron projection)|go:"GO:0043197"(dendritic spine)|go:"GO:0043457"(regulation of cellular respiration)|go:"GO:0044853"(plasma membrane raft)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045667"(regulation of osteoblast differentiation)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046827"(positive regulation of protein export from nucleus)|go:"GO:0048240"(sperm capacitation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048792"(spontaneous exocytosis of neurotransmitter)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0051447"(negative regulation of meiotic cell cycle)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051966"(regulation of synaptic transmission, glutamatergic)|go:"GO:0061136"(regulation of proteasomal protein catabolic process)|go:"GO:0070613"(regulation of protein processing)|go:"GO:0071333"(cellular response to glucose stimulus)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0097225"(sperm midpiece)|go:"GO:0097546"(ciliary base)|go:"GO:0098793"(presynapse)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1901621"(negative regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning)|go:"GO:2000810"(regulation of bicellular tight junction assembly)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000961(Protein kinase, C-terminal)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR044109|reactome:R-RNO-163615|reactome:R-RNO-164378|reactome:R-RNO-180024|reactome:R-RNO-2565942|reactome:R-RNO-380259|reactome:R-RNO-380270|reactome:R-RNO-380284|reactome:R-RNO-380320|reactome:R-RNO-381676|reactome:R-RNO-392517|reactome:R-RNO-422356|reactome:R-RNO-432040|reactome:R-RNO-4420097|reactome:R-RNO-442720|reactome:R-RNO-512988|reactome:R-RNO-5578775|reactome:R-RNO-5610785|reactome:R-RNO-5610787|reactome:R-RNO-5620912|reactome:R-RNO-5687128|reactome:R-RNO-8853659|reactome:R-RNO-8854518|reactome:R-RNO-8963896|reactome:R-RNO-983231	-	-	-	caution:"The participant EBI-349571(P68370) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919386(Q7TP47) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920972(Q5XIP9) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-916419(P11980) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919578(Q8R491) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920554(Q5U3Z7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920647(Q5U2X8) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920585(Q7TP24) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-779677(P05426) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-915744(P02454) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|agonist:Insulin was shown to increase or decrease GLUT4 protein interactions in specific cases.|comment:"Insulin decreased GLUT4 interactions with the following proteins: Q9ER30 (Sarcosin), P09527 (Rab-7), O88960 (N-ethylmaleimide sensitive), P09456 (PKA I regulatory subunit), P27881 (Hexokinase type II), P07872 (Acyl-coenzyme A oxidase), Q6DGF1 (Isocitrate dehydrogenase), Q9EQX9 (Ubiquitin-conjugating), Q63446 (Polyubiquitin), P24268 (Cathepsin D), Q91XW0 (Heat shock protein 86), Q5FVH0 (unknown), P58405 (Striatin 3), Q62667 (Major vault protein), Q66H50 (unknown), Q09167 (splicing factor), Q9JHU5 (Arfaptin 1)."|comment:"Insulin increased GLUT4 interaction with the following proteins:Q9Z1P2 (R-actinin-1), P45592 (Cofilin), Q9QXQ0 (R-actinin-4), P26473 (ADP-ribosylation factor), P26437 (ADP-ribosylation factor),   Q7TNP1 (Basigin 2), Q6P6R2 (Dihydrolipoamide dehydrogenase),   P04797 (GAPDH), Q63081 (Protein disulfide isomerase), P29457 (47 kDa heat shock protein), Q9R1J8 (Leprecan), O88638 (Putative eps protein),   Q64375 (Synaptonemal complex)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:NDPK - Interactions involving proteins containing InterPro domain IPR001564, Nucleoside diphosphate kinase, core.	taxid:10116(rat-l6)|taxid:10116(Rattus norvegicus)	-	2006/02/15	2021/11/30	rogid:PbFY2lfrty8yw40Jq7ShR7xfuV410116	rogid:vfm7xEYQfzaRDobnpGQh57Kpd6Q10116	intact-crc:44F3A2176D02515F|rigid:9RVm0UBcqQF4k06RGKO89Bg16Q8	false	myc tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P19357	uniprotkb:P63086	intact:EBI-915426|uniprotkb:P97900|ensembl:ENSRNOP00000023256	intact:EBI-397710|uniprotkb:P27703|ensembl:ENSRNOP00000002533	psi-mi:glut4_rat(display_long)|uniprotkb:Glucose transporter type 4, insulin-responsive(gene name synonym)|uniprotkb:Slc2a4(gene name)|psi-mi:Slc2a4(display_short)|uniprotkb:Glut4(gene name synonym)	psi-mi:mk01_rat(display_long)|uniprotkb:Mapk1(gene name)|psi-mi:Mapk1(display_short)|uniprotkb:Erk2(gene name synonym)|uniprotkb:Mapk(gene name synonym)|uniprotkb:Prkm1(gene name synonym)|uniprotkb:Extracellular signal-regulated kinase 2(gene name synonym)|uniprotkb:Mitogen-activated protein kinase 2(gene name synonym)|uniprotkb:MAP kinase isoform p42(gene name synonym)|uniprotkb:ERT1(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Foster et al. (2006)	pubmed:16396496|mint:MINT-5218203	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-921030	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2711|refseq:NP_036883.1|refseq:XP_006246658.1|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007611"(learning or memory)|go:"GO:0007614"(short-term memory)|go:"GO:0007616"(long-term memory)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010021"(amylopectin biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031550"(positive regulation of brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044381"(glucose import in response to insulin stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046323"(glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0098694"(regulation of synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0098793"(presynapse)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002441("Glucose transporter, type 4 (GLUT4)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-189200|ensembl:ENSRNOG00000017226(gene)|ensembl:ENSRNOT00000023256(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)	rgd:70500|refseq:NP_446294.1|refseq:XP_008767070.1|refseq:XP_006248720.1|refseq:XP_006248721.1|dip:DIP-29117N|go:"GO:0009636"(response to toxic substance)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010759"(positive regulation of macrophage chemotaxis)|go:"GO:0010800"(positive regulation of peptidyl-threonine phosphorylation)|go:"GO:0014032"(neural crest cell development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015966"(diadenosine tetraphosphate biosynthetic process)|go:"GO:0016301"(kinase activity)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0019858"(cytosine metabolic process)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019902"(phosphatase binding)|go:"GO:0030278"(regulation of ossification)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030424"(axon)|go:"GO:0030641"(regulation of cellular pH)|go:"GO:0030878"(thyroid gland development)|go:"GO:0031143"(pseudopodium)|go:"GO:0031435"(mitogen-activated protein kinase kinase kinase binding)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0032212"(positive regulation of telomere maintenance via telomerase)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0032872"(regulation of stress-activated MAPK cascade)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033598"(mammary gland epithelial cell proliferation)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0034614"(cellular response to reactive oxygen species)|go:"GO:0035094"(response to nicotine)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0038127"(ERBB signaling pathway)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0042473"(outer ear morphogenesis)|go:"GO:0042802"(identical protein binding)|go:"GO:0043204"(perikaryon)|go:"GO:0043330"(response to exogenous dsRNA)|go:"GO:0043627"(response to estrogen)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046697"(decidualization)|go:"GO:0048538"(thymus development)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0050853"(B cell receptor signaling pathway)|go:"GO:0051403"(stress-activated MAPK cascade)|go:"GO:0051493"(regulation of cytoskeleton organization)|go:"GO:0051973"(positive regulation of telomerase activity)|go:"GO:0060020"(Bergmann glial cell differentiation)|go:"GO:0060045"(positive regulation of cardiac muscle cell proliferation)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0060324"(face development)|go:"GO:0060425"(lung morphogenesis)|go:"GO:0060440"(trachea formation)|go:"GO:0060716"(labyrinthine layer blood vessel development)|go:"GO:0061308"(cardiac neural crest cell development involved in heart development)|go:"GO:0070371"(ERK1 and ERK2 cascade)|go:"GO:0070849"(response to epidermal growth factor)|go:"GO:0071276"(cellular response to cadmium ion)|go:"GO:0071310"(cellular response to organic substance)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0072584"(caveolin-mediated endocytosis)|go:"GO:0072686"(mitotic spindle)|go:"GO:0090170"(regulation of Golgi inheritance)|go:"GO:0097011"(cellular response to granulocyte macrophage colony-stimulating factor stimulus)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:0120041"(positive regulation of macrophage proliferation)|go:"GO:1903351"(cellular response to dopamine)|go:"GO:1904355"(positive regulation of telomere capping)|go:"GO:2000641"(regulation of early endosome to late endosome transport)|interpro:IPR000719(Protein kinase, core)|interpro:IPR003527(MAP kinase, conserved site)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR008349(ERK1/2 MAP kinase)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P63086|rcsb pdb:1ERK|rcsb pdb:1GOL|rcsb pdb:2ERK|rcsb pdb:2FYS|rcsb pdb:2GPH|rcsb pdb:2Z7L|rcsb pdb:3C9W|rcsb pdb:3ERK|rcsb pdb:3O71|rcsb pdb:3QYW|rcsb pdb:3QYZ|rcsb pdb:3R63|rcsb pdb:3ZU7|rcsb pdb:3ZUV|rcsb pdb:4ERK|rcsb pdb:4GSB|rcsb pdb:4GT3|rcsb pdb:4GVA|rcsb pdb:4I5H|rcsb pdb:4N4S|rcsb pdb:4QYY|rcsb pdb:4S2Z|rcsb pdb:4S30|rcsb pdb:4S31|rcsb pdb:4S32|rcsb pdb:4S33|rcsb pdb:4S34|rcsb pdb:4XNE|rcsb pdb:4XOY|rcsb pdb:4XOZ|rcsb pdb:4XP0|rcsb pdb:4XP2|rcsb pdb:4XP3|rcsb pdb:4XRJ|rcsb pdb:4XRL|rcsb pdb:5HD4|rcsb pdb:5HD7|rcsb pdb:5KE0|rcsb pdb:5U6I|rcsb pdb:5UMO|rcsb pdb:6CPW|rcsb pdb:6DCG|rcsb pdb:6FI3|rcsb pdb:6FI6|rcsb pdb:6FJ0|rcsb pdb:6FJB|rcsb pdb:6FJZ|rcsb pdb:6FLE|rcsb pdb:6FLV|rcsb pdb:6FMA|rcsb pdb:6FN5|rcsb pdb:6FQ7|rcsb pdb:6FR1|rcsb pdb:6FRP|rcsb pdb:6FXV|rcsb pdb:6OPK|rcsb pdb:6OT6|rcsb pdb:6OTS|rcsb pdb:6RFO|rcsb pdb:6RFP|reactome:R-RNO-111995|reactome:R-RNO-112409|reactome:R-RNO-112411|reactome:R-RNO-1295596|reactome:R-RNO-162658|reactome:R-RNO-170968|reactome:R-RNO-198753|reactome:R-RNO-202670|reactome:R-RNO-2029482|reactome:R-RNO-2559580|reactome:R-RNO-2559582|reactome:R-RNO-2559585|reactome:R-RNO-2871796|reactome:R-RNO-3371453|reactome:R-RNO-375165|reactome:R-RNO-437239|reactome:R-RNO-445144|reactome:R-RNO-450341|reactome:R-RNO-456926|reactome:R-RNO-5654726|reactome:R-RNO-5654727|reactome:R-RNO-5654732|reactome:R-RNO-5654733|reactome:R-RNO-5663213|reactome:R-RNO-5668599|reactome:R-RNO-5673001|reactome:R-RNO-5674135|reactome:R-RNO-5674499|reactome:R-RNO-5675221|reactome:R-RNO-6798695|reactome:R-RNO-6811558|reactome:R-RNO-74749|reactome:R-RNO-881907|reactome:R-RNO-8939211|reactome:R-RNO-9627069|reactome:R-RNO-9634635|reactome:R-RNO-9634638|reactome:R-RNO-982772|ensembl:ENSRNOG00000001849(gene)|ensembl:ENSRNOT00000002533(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004707"(MAP kinase activity)|go:"GO:0004708"(MAP kinase kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005769"(early endosome)|go:"GO:0005770"(late endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0005925"(focal adhesion)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006915"(apoptotic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007049"(cell cycle)|go:"GO:0007165"(signal transduction)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007507"(heart development)|go:"GO:0007568"(aging)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008353"(RNA polymerase II CTD heptapeptide repeat kinase activity)	-	-	-	caution:"The participant EBI-349571(P68370) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919386(Q7TP47) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920972(Q5XIP9) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-916419(P11980) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919578(Q8R491) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920554(Q5U3Z7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920647(Q5U2X8) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920585(Q7TP24) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-779677(P05426) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-915744(P02454) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|agonist:Insulin was shown to increase or decrease GLUT4 protein interactions in specific cases.|comment:"Insulin decreased GLUT4 interactions with the following proteins: Q9ER30 (Sarcosin), P09527 (Rab-7), O88960 (N-ethylmaleimide sensitive), P09456 (PKA I regulatory subunit), P27881 (Hexokinase type II), P07872 (Acyl-coenzyme A oxidase), Q6DGF1 (Isocitrate dehydrogenase), Q9EQX9 (Ubiquitin-conjugating), Q63446 (Polyubiquitin), P24268 (Cathepsin D), Q91XW0 (Heat shock protein 86), Q5FVH0 (unknown), P58405 (Striatin 3), Q62667 (Major vault protein), Q66H50 (unknown), Q09167 (splicing factor), Q9JHU5 (Arfaptin 1)."|comment:"Insulin increased GLUT4 interaction with the following proteins:Q9Z1P2 (R-actinin-1), P45592 (Cofilin), Q9QXQ0 (R-actinin-4), P26473 (ADP-ribosylation factor), P26437 (ADP-ribosylation factor),   Q7TNP1 (Basigin 2), Q6P6R2 (Dihydrolipoamide dehydrogenase),   P04797 (GAPDH), Q63081 (Protein disulfide isomerase), P29457 (47 kDa heat shock protein), Q9R1J8 (Leprecan), O88638 (Putative eps protein),   Q64375 (Synaptonemal complex)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:NDPK - Interactions involving proteins containing InterPro domain IPR001564, Nucleoside diphosphate kinase, core.	taxid:10116(rat-l6)|taxid:10116(Rattus norvegicus)	-	2006/02/15	2021/11/30	rogid:PbFY2lfrty8yw40Jq7ShR7xfuV410116	rogid:4STZhl2O+Ilh0lj8wQp8y2vVehA10116	intact-crc:44F3A2176D02515F|rigid:9RVm0UBcqQF4k06RGKO89Bg16Q8	false	myc tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P19357	uniprotkb:P27653	intact:EBI-915426|uniprotkb:P97900|ensembl:ENSRNOP00000023256	intact:EBI-917024|uniprotkb:Q62808	psi-mi:glut4_rat(display_long)|uniprotkb:Glucose transporter type 4, insulin-responsive(gene name synonym)|uniprotkb:Slc2a4(gene name)|psi-mi:Slc2a4(display_short)|uniprotkb:Glut4(gene name synonym)	psi-mi:c1tc_rat(display_long)|uniprotkb:Mthfd1(gene name)|psi-mi:Mthfd1(display_short)|uniprotkb:Mthfd(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Foster et al. (2006)	pubmed:16396496|mint:MINT-5218203	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-921030	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2711|refseq:NP_036883.1|refseq:XP_006246658.1|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007611"(learning or memory)|go:"GO:0007614"(short-term memory)|go:"GO:0007616"(long-term memory)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010021"(amylopectin biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031550"(positive regulation of brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044381"(glucose import in response to insulin stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046323"(glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0098694"(regulation of synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0098793"(presynapse)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002441("Glucose transporter, type 4 (GLUT4)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-189200|ensembl:ENSRNOG00000017226(gene)|ensembl:ENSRNOT00000023256(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)	interpro:IPR020628|interpro:IPR000672(Tetrahydrofolate dehydrogenase/cyclohydrolase)|interpro:IPR020630|rgd:708531|refseq:NP_071953.1|interpro:IPR000559(Formate-tetrahydrofolate ligase, FTHFS)|interpro:IPR020867|interpro:IPR020631|interpro:IPR027417|interpro:IPR036291|reactome:R-RNO-196757|go:"GO:0000105"(histidine biosynthetic process)|go:"GO:0001780"(neutrophil homeostasis)|go:"GO:0001843"(neural tube closure)|go:"GO:0004329"(formate-tetrahydrofolate ligase activity)|go:"GO:0004477"(methenyltetrahydrofolate cyclohydrolase activity)|go:"GO:0004486"("methylenetetrahydrofolate dehydrogenase [NAD(P)+] activity")|go:"GO:0004487"("methylenetetrahydrofolate dehydrogenase (NAD+) activity")|go:"GO:0004488"("methylenetetrahydrofolate dehydrogenase (NADP+) activity")|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006164"(purine nucleotide biosynthetic process)|go:"GO:0006555"(methionine metabolic process)|go:"GO:0006730"(one-carbon metabolic process)|go:"GO:0007507"(heart development)|go:"GO:0009069"(serine family amino acid metabolic process)|go:"GO:0009070"(serine family amino acid biosynthetic process)|go:"GO:0009086"(methionine biosynthetic process)|go:"GO:0009117"(nucleotide metabolic process)|go:"GO:0009257"(10-formyltetrahydrofolate biosynthetic process)|go:"GO:0019346"(transsulfuration)|go:"GO:0035713"(response to nitrogen dioxide)|go:"GO:0035999"(tetrahydrofolate interconversion)|go:"GO:0046653"(tetrahydrofolate metabolic process)|go:"GO:0061053"(somite development)	-	-	-	caution:"The participant EBI-349571(P68370) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919386(Q7TP47) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920972(Q5XIP9) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-916419(P11980) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919578(Q8R491) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920554(Q5U3Z7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920647(Q5U2X8) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920585(Q7TP24) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-779677(P05426) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-915744(P02454) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|agonist:Insulin was shown to increase or decrease GLUT4 protein interactions in specific cases.|comment:"Insulin decreased GLUT4 interactions with the following proteins: Q9ER30 (Sarcosin), P09527 (Rab-7), O88960 (N-ethylmaleimide sensitive), P09456 (PKA I regulatory subunit), P27881 (Hexokinase type II), P07872 (Acyl-coenzyme A oxidase), Q6DGF1 (Isocitrate dehydrogenase), Q9EQX9 (Ubiquitin-conjugating), Q63446 (Polyubiquitin), P24268 (Cathepsin D), Q91XW0 (Heat shock protein 86), Q5FVH0 (unknown), P58405 (Striatin 3), Q62667 (Major vault protein), Q66H50 (unknown), Q09167 (splicing factor), Q9JHU5 (Arfaptin 1)."|comment:"Insulin increased GLUT4 interaction with the following proteins:Q9Z1P2 (R-actinin-1), P45592 (Cofilin), Q9QXQ0 (R-actinin-4), P26473 (ADP-ribosylation factor), P26437 (ADP-ribosylation factor),   Q7TNP1 (Basigin 2), Q6P6R2 (Dihydrolipoamide dehydrogenase),   P04797 (GAPDH), Q63081 (Protein disulfide isomerase), P29457 (47 kDa heat shock protein), Q9R1J8 (Leprecan), O88638 (Putative eps protein),   Q64375 (Synaptonemal complex)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:NDPK - Interactions involving proteins containing InterPro domain IPR001564, Nucleoside diphosphate kinase, core.	taxid:10116(rat-l6)|taxid:10116(Rattus norvegicus)	-	2006/02/15	2021/11/30	rogid:PbFY2lfrty8yw40Jq7ShR7xfuV410116	rogid:b4ks+U+VMZMutaE+OwCta6uiWkE10116	intact-crc:44F3A2176D02515F|rigid:9RVm0UBcqQF4k06RGKO89Bg16Q8	false	myc tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P19357	uniprotkb:P27615	intact:EBI-915426|uniprotkb:P97900|ensembl:ENSRNOP00000023256	intact:EBI-917015|ensembl:ENSRNOP00000003052	psi-mi:glut4_rat(display_long)|uniprotkb:Glucose transporter type 4, insulin-responsive(gene name synonym)|uniprotkb:Slc2a4(gene name)|psi-mi:Slc2a4(display_short)|uniprotkb:Glut4(gene name synonym)	psi-mi:scrb2_rat(display_long)|uniprotkb:Lysosome membrane protein II(gene name synonym)|uniprotkb:Scavenger receptor class B member 2(gene name synonym)|uniprotkb:85 kDa lysosomal membrane sialoglycoprotein(gene name synonym)|uniprotkb:CD36 antigen-like 2(gene name synonym)|uniprotkb:Scarb2(gene name)|psi-mi:Scarb2(display_short)|uniprotkb:Cd36l2(gene name synonym)|uniprotkb:Limpii(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Foster et al. (2006)	pubmed:16396496|mint:MINT-5218203	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-921030	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2711|refseq:NP_036883.1|refseq:XP_006246658.1|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007611"(learning or memory)|go:"GO:0007614"(short-term memory)|go:"GO:0007616"(long-term memory)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010021"(amylopectin biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031550"(positive regulation of brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044381"(glucose import in response to insulin stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046323"(glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0098694"(regulation of synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0098793"(presynapse)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002441("Glucose transporter, type 4 (GLUT4)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-189200|ensembl:ENSRNOG00000017226(gene)|ensembl:ENSRNOT00000023256(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)	rgd:621882|refseq:NP_446453.1|ensembl:ENSRNOG00000002225(gene)|ensembl:ENSRNOT00000003052(transcript)|go:"GO:0001786"(phosphatidylserine binding)|go:"GO:0005044"(scavenger receptor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0006622"(protein targeting to lysosome)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0010467"(gene expression)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0015485"(cholesterol binding)|go:"GO:0015917"(aminophospholipid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019899"(enzyme binding)|go:"GO:0030666"(endocytic vesicle membrane)|go:"GO:0031210"(phosphatidylcholine binding)|go:"GO:0038024"(cargo receptor activity)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043202"(lysosomal lumen)|go:"GO:0043471"(regulation of cellular carbohydrate catabolic process)|go:"GO:0051087"(chaperone binding)|go:"GO:1905123"(regulation of glucosylceramidase activity)|interpro:IPR002159(CD36 antigen)|interpro:IPR005429(Lysosome membrane protein II)|reactome:R-RNO-8856825|reactome:R-RNO-8856828	-	-	-	caution:"The participant EBI-349571(P68370) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919386(Q7TP47) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920972(Q5XIP9) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-916419(P11980) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919578(Q8R491) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920554(Q5U3Z7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920647(Q5U2X8) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920585(Q7TP24) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-779677(P05426) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-915744(P02454) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|agonist:Insulin was shown to increase or decrease GLUT4 protein interactions in specific cases.|comment:"Insulin decreased GLUT4 interactions with the following proteins: Q9ER30 (Sarcosin), P09527 (Rab-7), O88960 (N-ethylmaleimide sensitive), P09456 (PKA I regulatory subunit), P27881 (Hexokinase type II), P07872 (Acyl-coenzyme A oxidase), Q6DGF1 (Isocitrate dehydrogenase), Q9EQX9 (Ubiquitin-conjugating), Q63446 (Polyubiquitin), P24268 (Cathepsin D), Q91XW0 (Heat shock protein 86), Q5FVH0 (unknown), P58405 (Striatin 3), Q62667 (Major vault protein), Q66H50 (unknown), Q09167 (splicing factor), Q9JHU5 (Arfaptin 1)."|comment:"Insulin increased GLUT4 interaction with the following proteins:Q9Z1P2 (R-actinin-1), P45592 (Cofilin), Q9QXQ0 (R-actinin-4), P26473 (ADP-ribosylation factor), P26437 (ADP-ribosylation factor),   Q7TNP1 (Basigin 2), Q6P6R2 (Dihydrolipoamide dehydrogenase),   P04797 (GAPDH), Q63081 (Protein disulfide isomerase), P29457 (47 kDa heat shock protein), Q9R1J8 (Leprecan), O88638 (Putative eps protein),   Q64375 (Synaptonemal complex)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:NDPK - Interactions involving proteins containing InterPro domain IPR001564, Nucleoside diphosphate kinase, core.	taxid:10116(rat-l6)|taxid:10116(Rattus norvegicus)	-	2006/02/15	2021/11/30	rogid:PbFY2lfrty8yw40Jq7ShR7xfuV410116	rogid:UaxnvpvlfsUPpKImkIjkevqxB2010116	intact-crc:44F3A2176D02515F|rigid:9RVm0UBcqQF4k06RGKO89Bg16Q8	false	myc tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P19357	uniprotkb:P27605	intact:EBI-915426|uniprotkb:P97900|ensembl:ENSRNOP00000023256	intact:EBI-917005|uniprotkb:P70469|uniprotkb:Q4KMC5|uniprotkb:Q62926|ensembl:ENSRNOP00000043388|ensembl:ENSRNOP00000062740	psi-mi:glut4_rat(display_long)|uniprotkb:Glucose transporter type 4, insulin-responsive(gene name synonym)|uniprotkb:Slc2a4(gene name)|psi-mi:Slc2a4(display_short)|uniprotkb:Glut4(gene name synonym)	psi-mi:hprt_rat(display_long)|uniprotkb:Hprt1(gene name)|psi-mi:Hprt1(display_short)|uniprotkb:Hprt(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Foster et al. (2006)	pubmed:16396496|mint:MINT-5218203	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-921030	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2711|refseq:NP_036883.1|refseq:XP_006246658.1|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007611"(learning or memory)|go:"GO:0007614"(short-term memory)|go:"GO:0007616"(long-term memory)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010021"(amylopectin biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031550"(positive regulation of brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044381"(glucose import in response to insulin stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046323"(glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0098694"(regulation of synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0098793"(presynapse)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002441("Glucose transporter, type 4 (GLUT4)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-189200|ensembl:ENSRNOG00000017226(gene)|ensembl:ENSRNOT00000023256(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)	rgd:2826|refseq:NP_036715.1|refseq:XP_008771881.1|ensembl:ENSRNOG00000031367(gene)|ensembl:ENSRNOG00000048561(gene)|ensembl:ENSRNOT00000045153(transcript)|ensembl:ENSRNOT00000065935(transcript)|go:"GO:0000166"(nucleotide binding)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0001913"(T cell mediated cytotoxicity)|go:"GO:0001975"(response to amphetamine)|go:"GO:0004422"(hypoxanthine phosphoribosyltransferase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0006164"(purine nucleotide biosynthetic process)|go:"GO:0006166"(purine ribonucleoside salvage)|go:"GO:0006168"(adenine salvage)|go:"GO:0006178"(guanine salvage)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007420"(brain development)|go:"GO:0007625"(grooming behavior)|go:"GO:0007626"(locomotory behavior)|go:"GO:0021756"(striatum development)|go:"GO:0021895"(cerebral cortex neuron differentiation)|go:"GO:0021954"(central nervous system neuron development)|go:"GO:0032263"(GMP salvage)|go:"GO:0032264"(IMP salvage)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042417"(dopamine metabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0043103"(hypoxanthine salvage)|go:"GO:0045964"(positive regulation of dopamine metabolic process)|go:"GO:0046038"(GMP catabolic process)|go:"GO:0046040"(IMP metabolic process)|go:"GO:0046083"(adenine metabolic process)|go:"GO:0046100"(hypoxanthine metabolic process)|go:"GO:0046651"(lymphocyte proliferation)|go:"GO:0048813"(dendrite morphogenesis)|go:"GO:0051289"(protein homotetramerization)|go:"GO:0052657"(guanine phosphoribosyltransferase activity)|interpro:IPR000836(Phosphoribosyltransferase)|interpro:IPR005904(Hypoxanthine phosphoribosyl transferase)|interpro:IPR029057|reactome:R-RNO-74217	-	-	-	caution:"The participant EBI-349571(P68370) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919386(Q7TP47) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920972(Q5XIP9) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-916419(P11980) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919578(Q8R491) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920554(Q5U3Z7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920647(Q5U2X8) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920585(Q7TP24) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-779677(P05426) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-915744(P02454) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|agonist:Insulin was shown to increase or decrease GLUT4 protein interactions in specific cases.|comment:"Insulin decreased GLUT4 interactions with the following proteins: Q9ER30 (Sarcosin), P09527 (Rab-7), O88960 (N-ethylmaleimide sensitive), P09456 (PKA I regulatory subunit), P27881 (Hexokinase type II), P07872 (Acyl-coenzyme A oxidase), Q6DGF1 (Isocitrate dehydrogenase), Q9EQX9 (Ubiquitin-conjugating), Q63446 (Polyubiquitin), P24268 (Cathepsin D), Q91XW0 (Heat shock protein 86), Q5FVH0 (unknown), P58405 (Striatin 3), Q62667 (Major vault protein), Q66H50 (unknown), Q09167 (splicing factor), Q9JHU5 (Arfaptin 1)."|comment:"Insulin increased GLUT4 interaction with the following proteins:Q9Z1P2 (R-actinin-1), P45592 (Cofilin), Q9QXQ0 (R-actinin-4), P26473 (ADP-ribosylation factor), P26437 (ADP-ribosylation factor),   Q7TNP1 (Basigin 2), Q6P6R2 (Dihydrolipoamide dehydrogenase),   P04797 (GAPDH), Q63081 (Protein disulfide isomerase), P29457 (47 kDa heat shock protein), Q9R1J8 (Leprecan), O88638 (Putative eps protein),   Q64375 (Synaptonemal complex)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:NDPK - Interactions involving proteins containing InterPro domain IPR001564, Nucleoside diphosphate kinase, core.	taxid:10116(rat-l6)|taxid:10116(Rattus norvegicus)	-	2006/02/15	2021/11/30	rogid:PbFY2lfrty8yw40Jq7ShR7xfuV410116	rogid:gm0u1QTRqRJVAysCQSvjyv+8ctU10116	intact-crc:44F3A2176D02515F|rigid:9RVm0UBcqQF4k06RGKO89Bg16Q8	false	myc tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P19357	uniprotkb:P26772	intact:EBI-915426|uniprotkb:P97900|ensembl:ENSRNOP00000023256	intact:EBI-916995	psi-mi:glut4_rat(display_long)|uniprotkb:Glucose transporter type 4, insulin-responsive(gene name synonym)|uniprotkb:Slc2a4(gene name)|psi-mi:Slc2a4(display_short)|uniprotkb:Glut4(gene name synonym)	psi-mi:ch10_rat(display_long)|uniprotkb:Chaperonin 10(gene name synonym)|uniprotkb:10 kDa chaperonin(gene name synonym)|uniprotkb:Hspe1(gene name)|psi-mi:Hspe1(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Foster et al. (2006)	pubmed:16396496|mint:MINT-5218203	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-921030	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2711|refseq:NP_036883.1|refseq:XP_006246658.1|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007611"(learning or memory)|go:"GO:0007614"(short-term memory)|go:"GO:0007616"(long-term memory)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010021"(amylopectin biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031550"(positive regulation of brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044381"(glucose import in response to insulin stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046323"(glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0098694"(regulation of synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0098793"(presynapse)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002441("Glucose transporter, type 4 (GLUT4)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-189200|ensembl:ENSRNOG00000017226(gene)|ensembl:ENSRNOT00000023256(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)	rgd:2844|interpro:IPR020818|interpro:IPR018369|interpro:IPR011032(GroES-like)|reactome:R-RNO-9013408|interpro:IPR037124|go:"GO:0005524"(ATP binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0046872"(metal ion binding)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051085"(chaperone cofactor-dependent protein refolding)|go:"GO:0051087"(chaperone binding)	-	-	-	caution:"The participant EBI-349571(P68370) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919386(Q7TP47) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920972(Q5XIP9) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-916419(P11980) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919578(Q8R491) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920554(Q5U3Z7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920647(Q5U2X8) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920585(Q7TP24) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-779677(P05426) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-915744(P02454) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|agonist:Insulin was shown to increase or decrease GLUT4 protein interactions in specific cases.|comment:"Insulin decreased GLUT4 interactions with the following proteins: Q9ER30 (Sarcosin), P09527 (Rab-7), O88960 (N-ethylmaleimide sensitive), P09456 (PKA I regulatory subunit), P27881 (Hexokinase type II), P07872 (Acyl-coenzyme A oxidase), Q6DGF1 (Isocitrate dehydrogenase), Q9EQX9 (Ubiquitin-conjugating), Q63446 (Polyubiquitin), P24268 (Cathepsin D), Q91XW0 (Heat shock protein 86), Q5FVH0 (unknown), P58405 (Striatin 3), Q62667 (Major vault protein), Q66H50 (unknown), Q09167 (splicing factor), Q9JHU5 (Arfaptin 1)."|comment:"Insulin increased GLUT4 interaction with the following proteins:Q9Z1P2 (R-actinin-1), P45592 (Cofilin), Q9QXQ0 (R-actinin-4), P26473 (ADP-ribosylation factor), P26437 (ADP-ribosylation factor),   Q7TNP1 (Basigin 2), Q6P6R2 (Dihydrolipoamide dehydrogenase),   P04797 (GAPDH), Q63081 (Protein disulfide isomerase), P29457 (47 kDa heat shock protein), Q9R1J8 (Leprecan), O88638 (Putative eps protein),   Q64375 (Synaptonemal complex)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:NDPK - Interactions involving proteins containing InterPro domain IPR001564, Nucleoside diphosphate kinase, core.	taxid:10116(rat-l6)|taxid:10116(Rattus norvegicus)	-	2006/02/15	2021/11/30	rogid:PbFY2lfrty8yw40Jq7ShR7xfuV410116	rogid:mmsB6NNzef0kMnkgqJiQtcVpQMs10116	intact-crc:44F3A2176D02515F|rigid:9RVm0UBcqQF4k06RGKO89Bg16Q8	false	myc tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P19357	uniprotkb:P84083	intact:EBI-915426|uniprotkb:P97900|ensembl:ENSRNOP00000023256	intact:EBI-916985|uniprotkb:P26437|ensembl:ENSRNOP00000010429	psi-mi:glut4_rat(display_long)|uniprotkb:Glucose transporter type 4, insulin-responsive(gene name synonym)|uniprotkb:Slc2a4(gene name)|psi-mi:Slc2a4(display_short)|uniprotkb:Glut4(gene name synonym)	psi-mi:arf5_rat(display_long)|uniprotkb:Arf5(gene name)|psi-mi:Arf5(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Foster et al. (2006)	pubmed:16396496|mint:MINT-5218203	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-921030	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2711|refseq:NP_036883.1|refseq:XP_006246658.1|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007611"(learning or memory)|go:"GO:0007614"(short-term memory)|go:"GO:0007616"(long-term memory)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010021"(amylopectin biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031550"(positive regulation of brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044381"(glucose import in response to insulin stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046323"(glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0098694"(regulation of synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0098793"(presynapse)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002441("Glucose transporter, type 4 (GLUT4)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-189200|ensembl:ENSRNOG00000017226(gene)|ensembl:ENSRNOT00000023256(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)	rgd:621278|refseq:NP_077063.1|ensembl:ENSRNOG00000007806(gene)|ensembl:ENSRNOT00000010429(transcript)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006890"(retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0048471"(perinuclear region of cytoplasm)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR006689(ARF/SAR superfamily)|interpro:IPR027417|reactome:R-RNO-6807878|reactome:R-RNO-6811434	-	-	-	caution:"The participant EBI-349571(P68370) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919386(Q7TP47) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920972(Q5XIP9) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-916419(P11980) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919578(Q8R491) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920554(Q5U3Z7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920647(Q5U2X8) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920585(Q7TP24) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-779677(P05426) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-915744(P02454) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|agonist:Insulin was shown to increase or decrease GLUT4 protein interactions in specific cases.|comment:"Insulin decreased GLUT4 interactions with the following proteins: Q9ER30 (Sarcosin), P09527 (Rab-7), O88960 (N-ethylmaleimide sensitive), P09456 (PKA I regulatory subunit), P27881 (Hexokinase type II), P07872 (Acyl-coenzyme A oxidase), Q6DGF1 (Isocitrate dehydrogenase), Q9EQX9 (Ubiquitin-conjugating), Q63446 (Polyubiquitin), P24268 (Cathepsin D), Q91XW0 (Heat shock protein 86), Q5FVH0 (unknown), P58405 (Striatin 3), Q62667 (Major vault protein), Q66H50 (unknown), Q09167 (splicing factor), Q9JHU5 (Arfaptin 1)."|comment:"Insulin increased GLUT4 interaction with the following proteins:Q9Z1P2 (R-actinin-1), P45592 (Cofilin), Q9QXQ0 (R-actinin-4), P26473 (ADP-ribosylation factor), P26437 (ADP-ribosylation factor),   Q7TNP1 (Basigin 2), Q6P6R2 (Dihydrolipoamide dehydrogenase),   P04797 (GAPDH), Q63081 (Protein disulfide isomerase), P29457 (47 kDa heat shock protein), Q9R1J8 (Leprecan), O88638 (Putative eps protein),   Q64375 (Synaptonemal complex)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:NDPK - Interactions involving proteins containing InterPro domain IPR001564, Nucleoside diphosphate kinase, core.	taxid:10116(rat-l6)|taxid:10116(Rattus norvegicus)	-	2006/02/15	2021/11/30	rogid:PbFY2lfrty8yw40Jq7ShR7xfuV410116	rogid:da8exbGR3MGxZ6CPZqLvqJbyUYI10116	intact-crc:44F3A2176D02515F|rigid:9RVm0UBcqQF4k06RGKO89Bg16Q8	false	myc tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P19357	uniprotkb:P26051	intact:EBI-915426|uniprotkb:P97900|ensembl:ENSRNOP00000023256	intact:EBI-916940|uniprotkb:Q99021	psi-mi:glut4_rat(display_long)|uniprotkb:Glucose transporter type 4, insulin-responsive(gene name synonym)|uniprotkb:Slc2a4(gene name)|psi-mi:Slc2a4(display_short)|uniprotkb:Glut4(gene name synonym)	psi-mi:cd44_rat(display_long)|uniprotkb:Phagocytic glycoprotein 1(gene name synonym)|uniprotkb:HUTCH-I(gene name synonym)|uniprotkb:Extracellular matrix receptor III(gene name synonym)|uniprotkb:GP90 lymphocyte homing/adhesion receptor(gene name synonym)|uniprotkb:Hermes antigen(gene name synonym)|uniprotkb:Hyaluronate receptor(gene name synonym)|uniprotkb:Cd44(gene name)|psi-mi:Cd44(display_short)|uniprotkb:Phagocytic glycoprotein I(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Foster et al. (2006)	pubmed:16396496|mint:MINT-5218203	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-921030	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2711|refseq:NP_036883.1|refseq:XP_006246658.1|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007611"(learning or memory)|go:"GO:0007614"(short-term memory)|go:"GO:0007616"(long-term memory)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010021"(amylopectin biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031550"(positive regulation of brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044381"(glucose import in response to insulin stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046323"(glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0098694"(regulation of synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0098793"(presynapse)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002441("Glucose transporter, type 4 (GLUT4)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-189200|ensembl:ENSRNOG00000017226(gene)|ensembl:ENSRNOT00000023256(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)	interpro:IPR043210|rgd:2307|interpro:IPR016186(C-type lectin-like)|interpro:IPR016187(C-type lectin fold)|interpro:IPR001231(CD44 antigen)|interpro:IPR000538(Link)|refseq:XP_006234693.1|reactome:R-RNO-1474228|reactome:R-RNO-202733|reactome:R-RNO-216083|reactome:R-RNO-2160916|reactome:R-RNO-6798695|go:"GO:0001558"(regulation of cell growth)|go:"GO:0001658"(branching involved in ureteric bud morphogenesis)|go:"GO:0001955"(blood vessel maturation)|go:"GO:0002246"(wound healing involved in inflammatory response)|go:"GO:0002906"(negative regulation of mature B cell apoptotic process)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005114"(type II transforming growth factor beta receptor binding)|go:"GO:0005154"(epidermal growth factor receptor binding)|go:"GO:0005540"(hyaluronic acid binding)|go:"GO:0005634"(nucleus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0006954"(inflammatory response)|go:"GO:0007155"(cell adhesion)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0014070"(response to organic cyclic compound)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016477"(cell migration)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030214"(hyaluronan catabolic process)|go:"GO:0031175"(neuron projection development)|go:"GO:0031258"(lamellipodium membrane)|go:"GO:0031667"(response to nutrient levels)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033031"(positive regulation of neutrophil apoptotic process)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0033189"(response to vitamin A)|go:"GO:0034116"(positive regulation of heterotypic cell-cell adhesion)|go:"GO:0034238"(macrophage fusion)|go:"GO:0035692"(macrophage migration inhibitory factor receptor complex)|go:"GO:0042110"(T cell activation)|go:"GO:0042995"(cell projection)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043518"(negative regulation of DNA damage response, signal transduction by p53 class mediator)|go:"GO:0044319"(wound healing, spreading of cells)|go:"GO:0044344"(cellular response to fibroblast growth factor stimulus)|go:"GO:0045590"(negative regulation of regulatory T cell differentiation)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0051216"(cartilage development)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0060442"(branching involved in prostate gland morphogenesis)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070487"(monocyte aggregation)|go:"GO:1900625"(positive regulation of monocyte aggregation)|go:"GO:1902166"(negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator)|go:"GO:2000392"(regulation of lamellipodium morphogenesis)|go:"GO:2000562"(negative regulation of CD4-positive, alpha-beta T cell proliferation)	-	-	-	caution:"The participant EBI-349571(P68370) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919386(Q7TP47) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920972(Q5XIP9) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-916419(P11980) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919578(Q8R491) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920554(Q5U3Z7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920647(Q5U2X8) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920585(Q7TP24) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-779677(P05426) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-915744(P02454) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|agonist:Insulin was shown to increase or decrease GLUT4 protein interactions in specific cases.|comment:"Insulin decreased GLUT4 interactions with the following proteins: Q9ER30 (Sarcosin), P09527 (Rab-7), O88960 (N-ethylmaleimide sensitive), P09456 (PKA I regulatory subunit), P27881 (Hexokinase type II), P07872 (Acyl-coenzyme A oxidase), Q6DGF1 (Isocitrate dehydrogenase), Q9EQX9 (Ubiquitin-conjugating), Q63446 (Polyubiquitin), P24268 (Cathepsin D), Q91XW0 (Heat shock protein 86), Q5FVH0 (unknown), P58405 (Striatin 3), Q62667 (Major vault protein), Q66H50 (unknown), Q09167 (splicing factor), Q9JHU5 (Arfaptin 1)."|comment:"Insulin increased GLUT4 interaction with the following proteins:Q9Z1P2 (R-actinin-1), P45592 (Cofilin), Q9QXQ0 (R-actinin-4), P26473 (ADP-ribosylation factor), P26437 (ADP-ribosylation factor),   Q7TNP1 (Basigin 2), Q6P6R2 (Dihydrolipoamide dehydrogenase),   P04797 (GAPDH), Q63081 (Protein disulfide isomerase), P29457 (47 kDa heat shock protein), Q9R1J8 (Leprecan), O88638 (Putative eps protein),   Q64375 (Synaptonemal complex)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:NDPK - Interactions involving proteins containing InterPro domain IPR001564, Nucleoside diphosphate kinase, core.	taxid:10116(rat-l6)|taxid:10116(Rattus norvegicus)	-	2006/02/15	2021/11/30	rogid:PbFY2lfrty8yw40Jq7ShR7xfuV410116	rogid:6VVPhgJGT624s5G5VuM0j26EOjU10116	intact-crc:44F3A2176D02515F|rigid:9RVm0UBcqQF4k06RGKO89Bg16Q8	false	myc tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P19357	uniprotkb:P63245	intact:EBI-915426|uniprotkb:P97900|ensembl:ENSRNOP00000023256	intact:EBI-296759|ensembl:ENSRNOP00000068758|ensembl:ENSRNOP00000074147|uniprotkb:P25388|uniprotkb:P99049	psi-mi:glut4_rat(display_long)|uniprotkb:Glucose transporter type 4, insulin-responsive(gene name synonym)|uniprotkb:Slc2a4(gene name)|psi-mi:Slc2a4(display_short)|uniprotkb:Glut4(gene name synonym)	psi-mi:rack1_rat(display_long)|uniprotkb:Guanine nucleotide-binding protein subunit beta-2-like 1(gene name synonym)|uniprotkb:Receptor for activated C kinase(gene name synonym)|uniprotkb:Receptor of activated protein kinase C 1(gene name synonym)|uniprotkb:Rack1(gene name)|psi-mi:Rack1(display_short)|uniprotkb:Gnb2l1(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Foster et al. (2006)	pubmed:16396496|mint:MINT-5218203	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-921030	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2711|refseq:NP_036883.1|refseq:XP_006246658.1|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007611"(learning or memory)|go:"GO:0007614"(short-term memory)|go:"GO:0007616"(long-term memory)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010021"(amylopectin biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031550"(positive regulation of brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044381"(glucose import in response to insulin stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046323"(glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0098694"(regulation of synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0098793"(presynapse)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002441("Glucose transporter, type 4 (GLUT4)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-189200|ensembl:ENSRNOG00000017226(gene)|ensembl:ENSRNOT00000023256(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)	go:"GO:0015935"(small ribosomal subunit)|go:"GO:0016020"(membrane)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0019899"(enzyme binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030178"(negative regulation of Wnt signaling pathway)|go:"GO:0030292"(protein tyrosine kinase inhibitor activity)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030332"(cyclin binding)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030425"(dendrite)|go:"GO:0030496"(midbody)|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0031334"(positive regulation of protein-containing complex assembly)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0032880"(regulation of protein localization)|ensembl:ENSRNOG00000049070(gene)|ensembl:ENSRNOT00000072179(transcript)|ensembl:ENSRNOT00000084232(transcript)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0001891"(phagocytic cup)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006412"(translation)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0007049"(cell cycle)|go:"GO:0007205"(protein kinase C-activating G protein-coupled receptor signaling pathway)|go:"GO:0007369"(gastrulation)|go:"GO:0008200"(ion channel inhibitor activity)|go:"GO:0008656"(cysteine-type endopeptidase activator activity involved in apoptotic process)|go:"GO:0010629"(negative regulation of gene expression)|ensembl:ENSRNOG00000052620(gene)|go:"GO:0035591"(signaling adaptor activity)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042998"(positive regulation of Golgi to plasma membrane protein transport)|go:"GO:0043005"(neuron projection)|go:"GO:0043022"(ribosome binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043204"(perikaryon)|go:"GO:0043473"(pigmentation)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0044297"(cell body)|go:"GO:0045879"(negative regulation of smoothened signaling pathway)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048511"(rhythmic process)|go:"GO:0050765"(negative regulation of phagocytosis)|go:"GO:0051302"(regulation of cell division)|go:"GO:0051343"(positive regulation of cyclic-nucleotide phosphodiesterase activity)|go:"GO:0033137"(negative regulation of peptidyl-serine phosphorylation)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051898"(negative regulation of protein kinase B signaling)|go:"GO:0051901"(positive regulation of mitochondrial depolarization)|go:"GO:0071333"(cellular response to glucose stimulus)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0072344"(rescue of stalled ribosome)|go:"GO:1903076"(regulation of protein localization to plasma membrane)|go:"GO:1903208"(negative regulation of hydrogen peroxide-induced neuron death)|go:"GO:1990630"(IRE1-RACK1-PP2A complex)|go:"GO:2000114"(regulation of establishment of cell polarity)|go:"GO:2000543"(positive regulation of gastrulation)|go:"GO:2001244"(positive regulation of intrinsic apoptotic signaling pathway)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR020472|interpro:IPR036322|go:"GO:0051434"(BH3 domain binding)|mint:P63245|reactome:R-RNO-5357905|reactome:R-RNO-5357956|reactome:R-RNO-5626978|rgd:69229|refseq:NP_570090.2	-	-	-	caution:"The participant EBI-349571(P68370) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919386(Q7TP47) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920972(Q5XIP9) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-916419(P11980) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919578(Q8R491) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920554(Q5U3Z7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920647(Q5U2X8) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920585(Q7TP24) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-779677(P05426) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-915744(P02454) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|agonist:Insulin was shown to increase or decrease GLUT4 protein interactions in specific cases.|comment:"Insulin decreased GLUT4 interactions with the following proteins: Q9ER30 (Sarcosin), P09527 (Rab-7), O88960 (N-ethylmaleimide sensitive), P09456 (PKA I regulatory subunit), P27881 (Hexokinase type II), P07872 (Acyl-coenzyme A oxidase), Q6DGF1 (Isocitrate dehydrogenase), Q9EQX9 (Ubiquitin-conjugating), Q63446 (Polyubiquitin), P24268 (Cathepsin D), Q91XW0 (Heat shock protein 86), Q5FVH0 (unknown), P58405 (Striatin 3), Q62667 (Major vault protein), Q66H50 (unknown), Q09167 (splicing factor), Q9JHU5 (Arfaptin 1)."|comment:"Insulin increased GLUT4 interaction with the following proteins:Q9Z1P2 (R-actinin-1), P45592 (Cofilin), Q9QXQ0 (R-actinin-4), P26473 (ADP-ribosylation factor), P26437 (ADP-ribosylation factor),   Q7TNP1 (Basigin 2), Q6P6R2 (Dihydrolipoamide dehydrogenase),   P04797 (GAPDH), Q63081 (Protein disulfide isomerase), P29457 (47 kDa heat shock protein), Q9R1J8 (Leprecan), O88638 (Putative eps protein),   Q64375 (Synaptonemal complex)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:NDPK - Interactions involving proteins containing InterPro domain IPR001564, Nucleoside diphosphate kinase, core.	taxid:10116(rat-l6)|taxid:10116(Rattus norvegicus)	-	2006/02/15	2021/11/30	rogid:PbFY2lfrty8yw40Jq7ShR7xfuV410116	rogid:LXHlhPtxUzHJNncoPteGw2iXsFg10116	intact-crc:44F3A2176D02515F|rigid:9RVm0UBcqQF4k06RGKO89Bg16Q8	false	myc tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P19357	uniprotkb:P25235	intact:EBI-915426|uniprotkb:P97900|ensembl:ENSRNOP00000023256	intact:EBI-916932|uniprotkb:Q6P9X0|ensembl:ENSRNOP00000063207	psi-mi:glut4_rat(display_long)|uniprotkb:Glucose transporter type 4, insulin-responsive(gene name synonym)|uniprotkb:Slc2a4(gene name)|psi-mi:Slc2a4(display_short)|uniprotkb:Glut4(gene name synonym)	psi-mi:rpn2_rat(display_long)|uniprotkb:Dolichyl-diphosphooligosaccharide--protein glycosyltransferase 63 kDa subunit(gene name synonym)|uniprotkb:Ribophorin-2(gene name synonym)|uniprotkb:Ribophorin II(gene name synonym)|uniprotkb:Rpn2(gene name)|psi-mi:Rpn2(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Foster et al. (2006)	pubmed:16396496|mint:MINT-5218203	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-921030	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2711|refseq:NP_036883.1|refseq:XP_006246658.1|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007611"(learning or memory)|go:"GO:0007614"(short-term memory)|go:"GO:0007616"(long-term memory)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010021"(amylopectin biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031550"(positive regulation of brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044381"(glucose import in response to insulin stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046323"(glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0098694"(regulation of synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0098793"(presynapse)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002441("Glucose transporter, type 4 (GLUT4)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-189200|ensembl:ENSRNOG00000017226(gene)|ensembl:ENSRNOT00000023256(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)	rgd:62075|refseq:NP_113886.1|ensembl:ENSRNOG00000007492(gene)|ensembl:ENSRNOT00000068135(transcript)|go:"GO:0000421"(autophagosome membrane)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0006487"(protein N-linked glycosylation)|go:"GO:0007568"(aging)|go:"GO:0008250"(oligosaccharyltransferase complex)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0042493"|go:"GO:0043022"(ribosome binding)|interpro:IPR008814(Ribophorin II)|mint:P25235	-	-	-	caution:"The participant EBI-349571(P68370) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919386(Q7TP47) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920972(Q5XIP9) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-916419(P11980) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919578(Q8R491) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920554(Q5U3Z7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920647(Q5U2X8) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920585(Q7TP24) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-779677(P05426) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-915744(P02454) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|agonist:Insulin was shown to increase or decrease GLUT4 protein interactions in specific cases.|comment:"Insulin decreased GLUT4 interactions with the following proteins: Q9ER30 (Sarcosin), P09527 (Rab-7), O88960 (N-ethylmaleimide sensitive), P09456 (PKA I regulatory subunit), P27881 (Hexokinase type II), P07872 (Acyl-coenzyme A oxidase), Q6DGF1 (Isocitrate dehydrogenase), Q9EQX9 (Ubiquitin-conjugating), Q63446 (Polyubiquitin), P24268 (Cathepsin D), Q91XW0 (Heat shock protein 86), Q5FVH0 (unknown), P58405 (Striatin 3), Q62667 (Major vault protein), Q66H50 (unknown), Q09167 (splicing factor), Q9JHU5 (Arfaptin 1)."|comment:"Insulin increased GLUT4 interaction with the following proteins:Q9Z1P2 (R-actinin-1), P45592 (Cofilin), Q9QXQ0 (R-actinin-4), P26473 (ADP-ribosylation factor), P26437 (ADP-ribosylation factor),   Q7TNP1 (Basigin 2), Q6P6R2 (Dihydrolipoamide dehydrogenase),   P04797 (GAPDH), Q63081 (Protein disulfide isomerase), P29457 (47 kDa heat shock protein), Q9R1J8 (Leprecan), O88638 (Putative eps protein),   Q64375 (Synaptonemal complex)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:NDPK - Interactions involving proteins containing InterPro domain IPR001564, Nucleoside diphosphate kinase, core.	taxid:10116(rat-l6)|taxid:10116(Rattus norvegicus)	-	2006/02/15	2021/11/30	rogid:PbFY2lfrty8yw40Jq7ShR7xfuV410116	rogid:N/aNyyEE54vfAkJqT29OJUONlhU10116	intact-crc:44F3A2176D02515F|rigid:9RVm0UBcqQF4k06RGKO89Bg16Q8	false	myc tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P19357	uniprotkb:P62919	intact:EBI-915426|uniprotkb:P97900|ensembl:ENSRNOP00000023256	intact:EBI-438554|ensembl:ENSRNOP00000046553|ensembl:ENSRNOP00000064566|ensembl:ENSRNOP00000067080|uniprotkb:A0JMZ6|uniprotkb:P25120	psi-mi:glut4_rat(display_long)|uniprotkb:Glucose transporter type 4, insulin-responsive(gene name synonym)|uniprotkb:Slc2a4(gene name)|psi-mi:Slc2a4(display_short)|uniprotkb:Glut4(gene name synonym)	psi-mi:rl8_rat(display_long)|uniprotkb:Rpl8(gene name)|psi-mi:Rpl8(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Foster et al. (2006)	pubmed:16396496|mint:MINT-5218203	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-921030	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2711|refseq:NP_036883.1|refseq:XP_006246658.1|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007611"(learning or memory)|go:"GO:0007614"(short-term memory)|go:"GO:0007616"(long-term memory)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010021"(amylopectin biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031550"(positive regulation of brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044381"(glucose import in response to insulin stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046323"(glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0098694"(regulation of synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0098793"(presynapse)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002441("Glucose transporter, type 4 (GLUT4)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-189200|ensembl:ENSRNOG00000017226(gene)|ensembl:ENSRNOT00000023256(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)	ensembl:ENSRNOG00000032635(gene)|ensembl:ENSRNOG00000048456(gene)|ensembl:ENSRNOG00000048523(gene)|ensembl:ENSRNOT00000041984(transcript)|ensembl:ENSRNOT00000073724(transcript)|ensembl:ENSRNOT00000075451(transcript)|go:"GO:0002181"(cytoplasmic translation)|go:"GO:0003723"(RNA binding)|go:"GO:0003735"(structural constituent of ribosome)|go:"GO:0014069"(postsynaptic density)|go:"GO:0022625"(cytosolic large ribosomal subunit)|go:"GO:0022626"(cytosolic ribosome)|go:"GO:0042788"(polysomal ribosome)|go:"GO:0045202"(synapse)|go:"GO:0098794"(postsynapse)|go:"GO:1990090"(cellular response to nerve growth factor stimulus)|go:"GO:1990932"(5.8S rRNA binding)|interpro:IPR002171(Ribosomal protein L2)|interpro:IPR008991(Translation protein SH3-like)|interpro:IPR012340(Nucleic acid-binding, OB-fold)|interpro:IPR014722(Translation protein SH3-like, subgroup)|interpro:IPR014726(Ribosomal protein L2, domain 3)|interpro:IPR022666|interpro:IPR022669|interpro:IPR022671|interpro:IPR023672|reactome:R-RNO-156827|reactome:R-RNO-1799339|reactome:R-RNO-6791226|reactome:R-RNO-72689|reactome:R-RNO-72706|reactome:R-RNO-975956|reactome:R-RNO-975957|rgd:619827|refseq:NP_001030088.2|refseq:XP_002729189.1|refseq:XP_017450875.1	-	-	-	caution:"The participant EBI-349571(P68370) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919386(Q7TP47) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920972(Q5XIP9) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-916419(P11980) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919578(Q8R491) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920554(Q5U3Z7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920647(Q5U2X8) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920585(Q7TP24) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-779677(P05426) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-915744(P02454) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|agonist:Insulin was shown to increase or decrease GLUT4 protein interactions in specific cases.|comment:"Insulin decreased GLUT4 interactions with the following proteins: Q9ER30 (Sarcosin), P09527 (Rab-7), O88960 (N-ethylmaleimide sensitive), P09456 (PKA I regulatory subunit), P27881 (Hexokinase type II), P07872 (Acyl-coenzyme A oxidase), Q6DGF1 (Isocitrate dehydrogenase), Q9EQX9 (Ubiquitin-conjugating), Q63446 (Polyubiquitin), P24268 (Cathepsin D), Q91XW0 (Heat shock protein 86), Q5FVH0 (unknown), P58405 (Striatin 3), Q62667 (Major vault protein), Q66H50 (unknown), Q09167 (splicing factor), Q9JHU5 (Arfaptin 1)."|comment:"Insulin increased GLUT4 interaction with the following proteins:Q9Z1P2 (R-actinin-1), P45592 (Cofilin), Q9QXQ0 (R-actinin-4), P26473 (ADP-ribosylation factor), P26437 (ADP-ribosylation factor),   Q7TNP1 (Basigin 2), Q6P6R2 (Dihydrolipoamide dehydrogenase),   P04797 (GAPDH), Q63081 (Protein disulfide isomerase), P29457 (47 kDa heat shock protein), Q9R1J8 (Leprecan), O88638 (Putative eps protein),   Q64375 (Synaptonemal complex)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:NDPK - Interactions involving proteins containing InterPro domain IPR001564, Nucleoside diphosphate kinase, core.	taxid:10116(rat-l6)|taxid:10116(Rattus norvegicus)	-	2006/02/15	2021/11/30	rogid:PbFY2lfrty8yw40Jq7ShR7xfuV410116	rogid:+b/ORzdCy/nqFLsKRV9VhIZgdjg10116	intact-crc:44F3A2176D02515F|rigid:9RVm0UBcqQF4k06RGKO89Bg16Q8	false	myc tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P19357	uniprotkb:P62859	intact:EBI-915426|uniprotkb:P97900|ensembl:ENSRNOP00000023256	intact:EBI-353018|ensembl:ENSRNOP00000060568|uniprotkb:P25112	psi-mi:glut4_rat(display_long)|uniprotkb:Glucose transporter type 4, insulin-responsive(gene name synonym)|uniprotkb:Slc2a4(gene name)|psi-mi:Slc2a4(display_short)|uniprotkb:Glut4(gene name synonym)	psi-mi:rs28_rat(display_long)|uniprotkb:Rps28(gene name)|psi-mi:Rps28(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Foster et al. (2006)	pubmed:16396496|mint:MINT-5218203	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-921030	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2711|refseq:NP_036883.1|refseq:XP_006246658.1|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007611"(learning or memory)|go:"GO:0007614"(short-term memory)|go:"GO:0007616"(long-term memory)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010021"(amylopectin biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031550"(positive regulation of brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044381"(glucose import in response to insulin stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046323"(glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0098694"(regulation of synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0098793"(presynapse)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002441("Glucose transporter, type 4 (GLUT4)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-189200|ensembl:ENSRNOG00000017226(gene)|ensembl:ENSRNOT00000023256(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)	ensembl:ENSRNOG00000042886(gene)|ensembl:ENSRNOT00000068323(transcript)|go:"GO:0000028"(ribosomal small subunit assembly)|go:"GO:0002181"(cytoplasmic translation)|go:"GO:0003723"(RNA binding)|go:"GO:0003735"(structural constituent of ribosome)|go:"GO:0006364"(rRNA processing)|go:"GO:0006412"(translation)|go:"GO:0022627"(cytosolic small ribosomal subunit)|go:"GO:0030490"(maturation of SSU-rRNA)|go:"GO:0042254"(ribosome biogenesis)|go:"GO:0042274"(ribosomal small subunit biogenesis)|go:"GO:0042788"(polysomal ribosome)|go:"GO:0098556"(cytoplasmic side of rough endoplasmic reticulum membrane)|interpro:IPR000289(Ribosomal protein S28e)|interpro:IPR012340(Nucleic acid-binding, OB-fold)|interpro:IPR028626|reactome:R-RNO-156827|reactome:R-RNO-1799339|reactome:R-RNO-6791226|reactome:R-RNO-72649|reactome:R-RNO-72689|reactome:R-RNO-72695|reactome:R-RNO-72702|reactome:R-RNO-72706|reactome:R-RNO-975956|reactome:R-RNO-975957|rgd:621046|refseq:NP_001099200.1	-	-	-	caution:"The participant EBI-349571(P68370) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919386(Q7TP47) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920972(Q5XIP9) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-916419(P11980) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919578(Q8R491) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920554(Q5U3Z7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920647(Q5U2X8) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920585(Q7TP24) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-779677(P05426) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-915744(P02454) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|agonist:Insulin was shown to increase or decrease GLUT4 protein interactions in specific cases.|comment:"Insulin decreased GLUT4 interactions with the following proteins: Q9ER30 (Sarcosin), P09527 (Rab-7), O88960 (N-ethylmaleimide sensitive), P09456 (PKA I regulatory subunit), P27881 (Hexokinase type II), P07872 (Acyl-coenzyme A oxidase), Q6DGF1 (Isocitrate dehydrogenase), Q9EQX9 (Ubiquitin-conjugating), Q63446 (Polyubiquitin), P24268 (Cathepsin D), Q91XW0 (Heat shock protein 86), Q5FVH0 (unknown), P58405 (Striatin 3), Q62667 (Major vault protein), Q66H50 (unknown), Q09167 (splicing factor), Q9JHU5 (Arfaptin 1)."|comment:"Insulin increased GLUT4 interaction with the following proteins:Q9Z1P2 (R-actinin-1), P45592 (Cofilin), Q9QXQ0 (R-actinin-4), P26473 (ADP-ribosylation factor), P26437 (ADP-ribosylation factor),   Q7TNP1 (Basigin 2), Q6P6R2 (Dihydrolipoamide dehydrogenase),   P04797 (GAPDH), Q63081 (Protein disulfide isomerase), P29457 (47 kDa heat shock protein), Q9R1J8 (Leprecan), O88638 (Putative eps protein),   Q64375 (Synaptonemal complex)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:NDPK - Interactions involving proteins containing InterPro domain IPR001564, Nucleoside diphosphate kinase, core.	taxid:10116(rat-l6)|taxid:10116(Rattus norvegicus)	-	2006/02/15	2021/11/30	rogid:PbFY2lfrty8yw40Jq7ShR7xfuV410116	rogid:G4t8mOlzIiHEOXu+uS+AfySWAnM10116	intact-crc:44F3A2176D02515F|rigid:9RVm0UBcqQF4k06RGKO89Bg16Q8	false	myc tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P19357	uniprotkb:P62853	intact:EBI-915426|uniprotkb:P97900|ensembl:ENSRNOP00000023256	intact:EBI-931961|uniprotkb:P25111|uniprotkb:Q3SYP7	psi-mi:glut4_rat(display_long)|uniprotkb:Glucose transporter type 4, insulin-responsive(gene name synonym)|uniprotkb:Slc2a4(gene name)|psi-mi:Slc2a4(display_short)|uniprotkb:Glut4(gene name synonym)	psi-mi:rs25_rat(display_long)|uniprotkb:Rps25(gene name)|psi-mi:Rps25(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Foster et al. (2006)	pubmed:16396496|mint:MINT-5218203	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-921030	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2711|refseq:NP_036883.1|refseq:XP_006246658.1|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007611"(learning or memory)|go:"GO:0007614"(short-term memory)|go:"GO:0007616"(long-term memory)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010021"(amylopectin biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031550"(positive regulation of brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044381"(glucose import in response to insulin stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046323"(glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0098694"(regulation of synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0098793"(presynapse)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002441("Glucose transporter, type 4 (GLUT4)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-189200|ensembl:ENSRNOG00000017226(gene)|ensembl:ENSRNOT00000023256(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)	rgd:621043|refseq:NP_001005528.1|interpro:IPR004977(Ribosomal protein S25)|mint:P62853|interpro:IPR036388|go:"GO:0000028"(ribosomal small subunit assembly)|go:"GO:0003735"(structural constituent of ribosome)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0005840"(ribosome)|go:"GO:0005844"(polysome)|go:"GO:0006364"(rRNA processing)|go:"GO:0014069"(postsynaptic density)|go:"GO:0022626"(cytosolic ribosome)|go:"GO:0022627"(cytosolic small ribosomal subunit)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0042274"(ribosomal small subunit biogenesis)|go:"GO:0045202"(synapse)|reactome:R-RNO-156827|reactome:R-RNO-1799339|reactome:R-RNO-6791226|reactome:R-RNO-72649|reactome:R-RNO-72689|reactome:R-RNO-72695|reactome:R-RNO-72702|reactome:R-RNO-72706|reactome:R-RNO-975956|reactome:R-RNO-975957	-	-	-	caution:"The participant EBI-349571(P68370) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919386(Q7TP47) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920972(Q5XIP9) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-916419(P11980) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919578(Q8R491) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920554(Q5U3Z7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920647(Q5U2X8) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920585(Q7TP24) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-779677(P05426) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-915744(P02454) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|agonist:Insulin was shown to increase or decrease GLUT4 protein interactions in specific cases.|comment:"Insulin decreased GLUT4 interactions with the following proteins: Q9ER30 (Sarcosin), P09527 (Rab-7), O88960 (N-ethylmaleimide sensitive), P09456 (PKA I regulatory subunit), P27881 (Hexokinase type II), P07872 (Acyl-coenzyme A oxidase), Q6DGF1 (Isocitrate dehydrogenase), Q9EQX9 (Ubiquitin-conjugating), Q63446 (Polyubiquitin), P24268 (Cathepsin D), Q91XW0 (Heat shock protein 86), Q5FVH0 (unknown), P58405 (Striatin 3), Q62667 (Major vault protein), Q66H50 (unknown), Q09167 (splicing factor), Q9JHU5 (Arfaptin 1)."|comment:"Insulin increased GLUT4 interaction with the following proteins:Q9Z1P2 (R-actinin-1), P45592 (Cofilin), Q9QXQ0 (R-actinin-4), P26473 (ADP-ribosylation factor), P26437 (ADP-ribosylation factor),   Q7TNP1 (Basigin 2), Q6P6R2 (Dihydrolipoamide dehydrogenase),   P04797 (GAPDH), Q63081 (Protein disulfide isomerase), P29457 (47 kDa heat shock protein), Q9R1J8 (Leprecan), O88638 (Putative eps protein),   Q64375 (Synaptonemal complex)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:NDPK - Interactions involving proteins containing InterPro domain IPR001564, Nucleoside diphosphate kinase, core.	taxid:10116(rat-l6)|taxid:10116(Rattus norvegicus)	-	2006/02/15	2021/11/30	rogid:PbFY2lfrty8yw40Jq7ShR7xfuV410116	rogid:7TqA4Q6+6VMzrzaUrACbwtJKfOM10116	intact-crc:44F3A2176D02515F|rigid:9RVm0UBcqQF4k06RGKO89Bg16Q8	false	myc tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P19357	uniprotkb:P24368	intact:EBI-915426|uniprotkb:P97900|ensembl:ENSRNOP00000023256	intact:EBI-916926|uniprotkb:O88541|ensembl:ENSRNOP00000022828	psi-mi:glut4_rat(display_long)|uniprotkb:Glucose transporter type 4, insulin-responsive(gene name synonym)|uniprotkb:Slc2a4(gene name)|psi-mi:Slc2a4(display_short)|uniprotkb:Glut4(gene name synonym)	psi-mi:ppib_rat(display_long)|uniprotkb:Cyclophilin B(gene name synonym)|uniprotkb:S-cyclophilin(gene name synonym)|uniprotkb:CYP-S1(gene name synonym)|uniprotkb:Ppib(gene name)|psi-mi:Ppib(display_short)|uniprotkb:Rotamase B(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Foster et al. (2006)	pubmed:16396496|mint:MINT-5218203	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-921030	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2711|refseq:NP_036883.1|refseq:XP_006246658.1|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007611"(learning or memory)|go:"GO:0007614"(short-term memory)|go:"GO:0007616"(long-term memory)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010021"(amylopectin biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031550"(positive regulation of brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044381"(glucose import in response to insulin stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046323"(glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0098694"(regulation of synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0098793"(presynapse)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002441("Glucose transporter, type 4 (GLUT4)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-189200|ensembl:ENSRNOG00000017226(gene)|ensembl:ENSRNOT00000023256(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)	rgd:620312|refseq:NP_071981.1|ensembl:ENSRNOG00000016781(gene)|ensembl:ENSRNOT00000022828(transcript)|go:"GO:0000413"(protein peptidyl-prolyl isomerization)|go:"GO:0003755"(peptidyl-prolyl cis-trans isomerase activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005790"(smooth endoplasmic reticulum)|go:"GO:0006457"(protein folding)|go:"GO:0016018"(cyclosporin A binding)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034663"(endoplasmic reticulum chaperone complex)|go:"GO:0040018"(positive regulation of multicellular organism growth)|go:"GO:0042470"(melanosome)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044794"(positive regulation by host of viral process)|go:"GO:0044829"(positive regulation by host of viral genome replication)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050821"(protein stabilization)|go:"GO:0051169"(nuclear transport)|go:"GO:0060348"(bone development)|go:"GO:0061077"(chaperone-mediated protein folding)|go:"GO:0070063"(RNA polymerase binding)|interpro:IPR002130(Peptidyl-prolyl cis-trans isomerase, cyclophilin-type)|interpro:IPR020892|interpro:IPR029000|mint:P24368|reactome:R-RNO-1650814	-	-	-	caution:"The participant EBI-349571(P68370) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919386(Q7TP47) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920972(Q5XIP9) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-916419(P11980) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919578(Q8R491) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920554(Q5U3Z7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920647(Q5U2X8) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920585(Q7TP24) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-779677(P05426) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-915744(P02454) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|agonist:Insulin was shown to increase or decrease GLUT4 protein interactions in specific cases.|comment:"Insulin decreased GLUT4 interactions with the following proteins: Q9ER30 (Sarcosin), P09527 (Rab-7), O88960 (N-ethylmaleimide sensitive), P09456 (PKA I regulatory subunit), P27881 (Hexokinase type II), P07872 (Acyl-coenzyme A oxidase), Q6DGF1 (Isocitrate dehydrogenase), Q9EQX9 (Ubiquitin-conjugating), Q63446 (Polyubiquitin), P24268 (Cathepsin D), Q91XW0 (Heat shock protein 86), Q5FVH0 (unknown), P58405 (Striatin 3), Q62667 (Major vault protein), Q66H50 (unknown), Q09167 (splicing factor), Q9JHU5 (Arfaptin 1)."|comment:"Insulin increased GLUT4 interaction with the following proteins:Q9Z1P2 (R-actinin-1), P45592 (Cofilin), Q9QXQ0 (R-actinin-4), P26473 (ADP-ribosylation factor), P26437 (ADP-ribosylation factor),   Q7TNP1 (Basigin 2), Q6P6R2 (Dihydrolipoamide dehydrogenase),   P04797 (GAPDH), Q63081 (Protein disulfide isomerase), P29457 (47 kDa heat shock protein), Q9R1J8 (Leprecan), O88638 (Putative eps protein),   Q64375 (Synaptonemal complex)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:NDPK - Interactions involving proteins containing InterPro domain IPR001564, Nucleoside diphosphate kinase, core.	taxid:10116(rat-l6)|taxid:10116(Rattus norvegicus)	-	2006/02/15	2021/11/30	rogid:PbFY2lfrty8yw40Jq7ShR7xfuV410116	rogid:U3EtN9TrcUae1mOrkTbPtJd4zT810116	intact-crc:44F3A2176D02515F|rigid:9RVm0UBcqQF4k06RGKO89Bg16Q8	false	myc tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P19357	uniprotkb:P24268	intact:EBI-915426|uniprotkb:P97900|ensembl:ENSRNOP00000023256	intact:EBI-916915	psi-mi:glut4_rat(display_long)|uniprotkb:Glucose transporter type 4, insulin-responsive(gene name synonym)|uniprotkb:Slc2a4(gene name)|psi-mi:Slc2a4(display_short)|uniprotkb:Glut4(gene name synonym)	psi-mi:catd_rat(display_long)|uniprotkb:Ctsd(gene name)|psi-mi:Ctsd(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Foster et al. (2006)	pubmed:16396496|mint:MINT-5218203	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-921030	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2711|refseq:NP_036883.1|refseq:XP_006246658.1|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007611"(learning or memory)|go:"GO:0007614"(short-term memory)|go:"GO:0007616"(long-term memory)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010021"(amylopectin biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031550"(positive regulation of brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044381"(glucose import in response to insulin stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046323"(glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0098694"(regulation of synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0098793"(presynapse)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002441("Glucose transporter, type 4 (GLUT4)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-189200|ensembl:ENSRNOG00000017226(gene)|ensembl:ENSRNOT00000023256(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)	rgd:621511|interpro:IPR001461(Peptidase A1)|interpro:IPR021109|interpro:IPR001969(Peptidase aspartic, active site)|interpro:IPR012848(Propeptide, peptidase A1)|rcsb pdb:5UX4|interpro:IPR033121|interpro:IPR033144|reactome:R-RNO-1442490|reactome:R-RNO-2022377|reactome:R-RNO-2132295|reactome:R-RNO-6798695|go:"GO:0000045"(autophagosome assembly)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004190"(aspartic-type endopeptidase activity)|go:"GO:0005615"(extracellular space)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0006508"(proteolysis)|go:"GO:0008233"(peptidase activity)|go:"GO:0010008"(endosome membrane)|go:"GO:0016787"(hydrolase activity)|go:"GO:0031667"(response to nutrient levels)|go:"GO:0042159"(lipoprotein catabolic process)|go:"GO:0042277"(peptide binding)|go:"GO:0042470"(melanosome)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0045121"(membrane raft)|go:"GO:0070001"(aspartic-type peptidase activity)|go:"GO:0070201"(regulation of establishment of protein localization)	-	-	-	caution:"The participant EBI-349571(P68370) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919386(Q7TP47) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920972(Q5XIP9) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-916419(P11980) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919578(Q8R491) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920554(Q5U3Z7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920647(Q5U2X8) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920585(Q7TP24) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-779677(P05426) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-915744(P02454) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|agonist:Insulin was shown to increase or decrease GLUT4 protein interactions in specific cases.|comment:"Insulin decreased GLUT4 interactions with the following proteins: Q9ER30 (Sarcosin), P09527 (Rab-7), O88960 (N-ethylmaleimide sensitive), P09456 (PKA I regulatory subunit), P27881 (Hexokinase type II), P07872 (Acyl-coenzyme A oxidase), Q6DGF1 (Isocitrate dehydrogenase), Q9EQX9 (Ubiquitin-conjugating), Q63446 (Polyubiquitin), P24268 (Cathepsin D), Q91XW0 (Heat shock protein 86), Q5FVH0 (unknown), P58405 (Striatin 3), Q62667 (Major vault protein), Q66H50 (unknown), Q09167 (splicing factor), Q9JHU5 (Arfaptin 1)."|comment:"Insulin increased GLUT4 interaction with the following proteins:Q9Z1P2 (R-actinin-1), P45592 (Cofilin), Q9QXQ0 (R-actinin-4), P26473 (ADP-ribosylation factor), P26437 (ADP-ribosylation factor),   Q7TNP1 (Basigin 2), Q6P6R2 (Dihydrolipoamide dehydrogenase),   P04797 (GAPDH), Q63081 (Protein disulfide isomerase), P29457 (47 kDa heat shock protein), Q9R1J8 (Leprecan), O88638 (Putative eps protein),   Q64375 (Synaptonemal complex)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:NDPK - Interactions involving proteins containing InterPro domain IPR001564, Nucleoside diphosphate kinase, core.	taxid:10116(rat-l6)|taxid:10116(Rattus norvegicus)	-	2006/02/15	2021/11/30	rogid:PbFY2lfrty8yw40Jq7ShR7xfuV410116	rogid://kJGuCLwGdsWGUEC9wCQrS/5f810116	intact-crc:44F3A2176D02515F|rigid:9RVm0UBcqQF4k06RGKO89Bg16Q8	false	myc tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P19357	uniprotkb:P67779	intact:EBI-915426|uniprotkb:P97900|ensembl:ENSRNOP00000023256	intact:EBI-298513|uniprotkb:P24142|uniprotkb:Q4V8M6|ensembl:ENSRNOP00000066502	psi-mi:glut4_rat(display_long)|uniprotkb:Glucose transporter type 4, insulin-responsive(gene name synonym)|uniprotkb:Slc2a4(gene name)|psi-mi:Slc2a4(display_short)|uniprotkb:Glut4(gene name synonym)	psi-mi:phb_rat(display_long)|uniprotkb:Phb(gene name)|psi-mi:Phb(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Foster et al. (2006)	pubmed:16396496|mint:MINT-5218203	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-921030	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2711|refseq:NP_036883.1|refseq:XP_006246658.1|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007611"(learning or memory)|go:"GO:0007614"(short-term memory)|go:"GO:0007616"(long-term memory)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010021"(amylopectin biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031550"(positive regulation of brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044381"(glucose import in response to insulin stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046323"(glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0098694"(regulation of synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0098793"(presynapse)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002441("Glucose transporter, type 4 (GLUT4)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-189200|ensembl:ENSRNOG00000017226(gene)|ensembl:ENSRNOT00000023256(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)	go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005737"(cytoplasm)|go:"GO:0005769"(early endosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0007202"(activation of phospholipase C activity)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009986"(cell surface)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010942"(positive regulation of cell death)|go:"GO:0010944"(negative regulation of transcription by competitive promoter binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016575"(histone deacetylation)|go:"GO:0019899"(enzyme binding)|go:"GO:0023035"(CD40 signaling pathway)|go:"GO:0030061"(mitochondrial crista)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0031100"(animal organ regeneration)|go:"GO:0031315"(extrinsic component of mitochondrial outer membrane)|go:"GO:0031871"(proteinase activated receptor binding)|go:"GO:0032740"(positive regulation of interleukin-17 production)|go:"GO:0034097"(response to cytokine)|go:"GO:0035632"(mitochondrial prohibitin complex)|go:"GO:0035902"(response to immobilization stress)|go:"GO:0039529"(RIG-I signaling pathway)|go:"GO:0042113"(B cell activation)|go:"GO:0042177"(negative regulation of protein catabolic process)|go:"GO:0042493"|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043434"(response to peptide hormone)|go:"GO:0044830"(modulation by host of viral RNA genome replication)|go:"GO:0045471"(response to ethanol)|go:"GO:0045745"(positive regulation of G protein-coupled receptor signaling pathway)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045917"(positive regulation of complement activation)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0050821"(protein stabilization)|go:"GO:0050847"(progesterone receptor signaling pathway)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0060766"(negative regulation of androgen receptor signaling pathway)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071354"(cellular response to interleukin-6)|go:"GO:0071897"(DNA biosynthetic process)|go:"GO:0072538"(T-helper 17 type immune response)|go:"GO:0098891"(extrinsic component of presynaptic active zone membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0042826"(histone deacetylase binding)|ensembl:ENSRNOG00000046799(gene)|ensembl:ENSRNOT00000075733(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001541"(ovarian follicle development)|go:"GO:0001552"(ovarian follicle atresia)|go:"GO:0001850"(complement component C3a binding)|go:"GO:0001851"(complement component C3b binding)|go:"GO:0002639"(positive regulation of immunoglobulin production)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0140374"(antiviral innate immune response)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:1990051"(activation of protein kinase C activity)|go:"GO:2000323"(negative regulation of glucocorticoid receptor signaling pathway)|interpro:IPR000163(Prohibitin)|interpro:IPR001107(Band 7 protein)|go:"GO:0098982"(GABA-ergic synapse)|interpro:IPR036013|mint:P67779|reactome:R-RNO-5673000|reactome:R-RNO-8949664|rgd:3322|refseq:NP_114039.1	-	-	-	caution:"The participant EBI-349571(P68370) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919386(Q7TP47) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920972(Q5XIP9) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-916419(P11980) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919578(Q8R491) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920554(Q5U3Z7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920647(Q5U2X8) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920585(Q7TP24) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-779677(P05426) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-915744(P02454) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|agonist:Insulin was shown to increase or decrease GLUT4 protein interactions in specific cases.|comment:"Insulin decreased GLUT4 interactions with the following proteins: Q9ER30 (Sarcosin), P09527 (Rab-7), O88960 (N-ethylmaleimide sensitive), P09456 (PKA I regulatory subunit), P27881 (Hexokinase type II), P07872 (Acyl-coenzyme A oxidase), Q6DGF1 (Isocitrate dehydrogenase), Q9EQX9 (Ubiquitin-conjugating), Q63446 (Polyubiquitin), P24268 (Cathepsin D), Q91XW0 (Heat shock protein 86), Q5FVH0 (unknown), P58405 (Striatin 3), Q62667 (Major vault protein), Q66H50 (unknown), Q09167 (splicing factor), Q9JHU5 (Arfaptin 1)."|comment:"Insulin increased GLUT4 interaction with the following proteins:Q9Z1P2 (R-actinin-1), P45592 (Cofilin), Q9QXQ0 (R-actinin-4), P26473 (ADP-ribosylation factor), P26437 (ADP-ribosylation factor),   Q7TNP1 (Basigin 2), Q6P6R2 (Dihydrolipoamide dehydrogenase),   P04797 (GAPDH), Q63081 (Protein disulfide isomerase), P29457 (47 kDa heat shock protein), Q9R1J8 (Leprecan), O88638 (Putative eps protein),   Q64375 (Synaptonemal complex)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:NDPK - Interactions involving proteins containing InterPro domain IPR001564, Nucleoside diphosphate kinase, core.	taxid:10116(rat-l6)|taxid:10116(Rattus norvegicus)	-	2006/02/15	2021/11/30	rogid:PbFY2lfrty8yw40Jq7ShR7xfuV410116	rogid:eUStcZ9Mu7+7MHr/GJXFwwJY/Fc10116	intact-crc:44F3A2176D02515F|rigid:9RVm0UBcqQF4k06RGKO89Bg16Q8	false	myc tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P19357	uniprotkb:P24050	intact:EBI-915426|uniprotkb:P97900|ensembl:ENSRNOP00000023256	intact:EBI-916909	psi-mi:glut4_rat(display_long)|uniprotkb:Glucose transporter type 4, insulin-responsive(gene name synonym)|uniprotkb:Slc2a4(gene name)|psi-mi:Slc2a4(display_short)|uniprotkb:Glut4(gene name synonym)	psi-mi:rs5_rat(display_long)|uniprotkb:Rps5(gene name)|psi-mi:Rps5(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Foster et al. (2006)	pubmed:16396496|mint:MINT-5218203	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-921030	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2711|refseq:NP_036883.1|refseq:XP_006246658.1|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007611"(learning or memory)|go:"GO:0007614"(short-term memory)|go:"GO:0007616"(long-term memory)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010021"(amylopectin biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031550"(positive regulation of brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044381"(glucose import in response to insulin stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046323"(glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0098694"(regulation of synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0098793"(presynapse)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002441("Glucose transporter, type 4 (GLUT4)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-189200|ensembl:ENSRNOG00000017226(gene)|ensembl:ENSRNOT00000023256(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)	rgd:3601|interpro:IPR000235(Ribosomal protein S7)|interpro:IPR020606|interpro:IPR023798|interpro:IPR005716(Ribosomal protein S7, eukaryotic/archaeal)|interpro:IPR036823|reactome:R-RNO-156827|reactome:R-RNO-1799339|reactome:R-RNO-6791226|reactome:R-RNO-72649|reactome:R-RNO-72689|reactome:R-RNO-72695|reactome:R-RNO-72702|reactome:R-RNO-72706|reactome:R-RNO-975956|reactome:R-RNO-975957|go:"GO:0000028"(ribosomal small subunit assembly)|go:"GO:0003729"(mRNA binding)|go:"GO:0003735"(structural constituent of ribosome)|go:"GO:0005840"(ribosome)|go:"GO:0006412"(translation)|go:"GO:0006450"(regulation of translational fidelity)|go:"GO:0019843"(rRNA binding)|go:"GO:0022626"(cytosolic ribosome)|go:"GO:0022627"(cytosolic small ribosomal subunit)|go:"GO:1990904"(ribonucleoprotein complex)	-	-	-	caution:"The participant EBI-349571(P68370) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919386(Q7TP47) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920972(Q5XIP9) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-916419(P11980) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919578(Q8R491) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920554(Q5U3Z7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920647(Q5U2X8) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920585(Q7TP24) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-779677(P05426) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-915744(P02454) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|agonist:Insulin was shown to increase or decrease GLUT4 protein interactions in specific cases.|comment:"Insulin decreased GLUT4 interactions with the following proteins: Q9ER30 (Sarcosin), P09527 (Rab-7), O88960 (N-ethylmaleimide sensitive), P09456 (PKA I regulatory subunit), P27881 (Hexokinase type II), P07872 (Acyl-coenzyme A oxidase), Q6DGF1 (Isocitrate dehydrogenase), Q9EQX9 (Ubiquitin-conjugating), Q63446 (Polyubiquitin), P24268 (Cathepsin D), Q91XW0 (Heat shock protein 86), Q5FVH0 (unknown), P58405 (Striatin 3), Q62667 (Major vault protein), Q66H50 (unknown), Q09167 (splicing factor), Q9JHU5 (Arfaptin 1)."|comment:"Insulin increased GLUT4 interaction with the following proteins:Q9Z1P2 (R-actinin-1), P45592 (Cofilin), Q9QXQ0 (R-actinin-4), P26473 (ADP-ribosylation factor), P26437 (ADP-ribosylation factor),   Q7TNP1 (Basigin 2), Q6P6R2 (Dihydrolipoamide dehydrogenase),   P04797 (GAPDH), Q63081 (Protein disulfide isomerase), P29457 (47 kDa heat shock protein), Q9R1J8 (Leprecan), O88638 (Putative eps protein),   Q64375 (Synaptonemal complex)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:NDPK - Interactions involving proteins containing InterPro domain IPR001564, Nucleoside diphosphate kinase, core.	taxid:10116(rat-l6)|taxid:10116(Rattus norvegicus)	-	2006/02/15	2021/11/30	rogid:PbFY2lfrty8yw40Jq7ShR7xfuV410116	rogid:p6PSD7XgVg41bE1nivkgltfpm0c10116	intact-crc:44F3A2176D02515F|rigid:9RVm0UBcqQF4k06RGKO89Bg16Q8	false	myc tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P19357	uniprotkb:P23965	intact:EBI-915426|uniprotkb:P97900|ensembl:ENSRNOP00000023256	intact:EBI-916901	psi-mi:glut4_rat(display_long)|uniprotkb:Glucose transporter type 4, insulin-responsive(gene name synonym)|uniprotkb:Slc2a4(gene name)|psi-mi:Slc2a4(display_short)|uniprotkb:Glut4(gene name synonym)	psi-mi:eci1_rat(display_long)|uniprotkb:Dci(gene name synonym)|uniprotkb:3,2-trans-enoyl-CoA isomerase(gene name synonym)|uniprotkb:Dodecenoyl-CoA isomerase(gene name synonym)|uniprotkb:"Delta(3),Delta(2)-enoyl-CoA isomerase"(gene name synonym)|uniprotkb:Eci1(gene name)|psi-mi:Eci1(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Foster et al. (2006)	pubmed:16396496|mint:MINT-5218203	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-921030	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2711|refseq:NP_036883.1|refseq:XP_006246658.1|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007611"(learning or memory)|go:"GO:0007614"(short-term memory)|go:"GO:0007616"(long-term memory)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010021"(amylopectin biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031550"(positive regulation of brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044381"(glucose import in response to insulin stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046323"(glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0098694"(regulation of synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0098793"(presynapse)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002441("Glucose transporter, type 4 (GLUT4)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-189200|ensembl:ENSRNOG00000017226(gene)|ensembl:ENSRNOT00000023256(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)	rgd:61892|interpro:IPR001753(Crotonase, core)|interpro:IPR018376|rcsb pdb:1XX4|interpro:IPR029045|reactome:R-RNO-77288|go:"GO:0004165"("delta(3)-delta(2)-enoyl-CoA isomerase activity")|go:"GO:0004300"(enoyl-CoA hydratase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0006635"(fatty acid beta-oxidation)|go:"GO:0016863"(intramolecular oxidoreductase activity, transposing C=C bonds)|go:"GO:0042802"(identical protein binding)	-	-	-	caution:"The participant EBI-349571(P68370) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919386(Q7TP47) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920972(Q5XIP9) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-916419(P11980) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919578(Q8R491) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920554(Q5U3Z7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920647(Q5U2X8) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920585(Q7TP24) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-779677(P05426) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-915744(P02454) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|agonist:Insulin was shown to increase or decrease GLUT4 protein interactions in specific cases.|comment:"Insulin decreased GLUT4 interactions with the following proteins: Q9ER30 (Sarcosin), P09527 (Rab-7), O88960 (N-ethylmaleimide sensitive), P09456 (PKA I regulatory subunit), P27881 (Hexokinase type II), P07872 (Acyl-coenzyme A oxidase), Q6DGF1 (Isocitrate dehydrogenase), Q9EQX9 (Ubiquitin-conjugating), Q63446 (Polyubiquitin), P24268 (Cathepsin D), Q91XW0 (Heat shock protein 86), Q5FVH0 (unknown), P58405 (Striatin 3), Q62667 (Major vault protein), Q66H50 (unknown), Q09167 (splicing factor), Q9JHU5 (Arfaptin 1)."|comment:"Insulin increased GLUT4 interaction with the following proteins:Q9Z1P2 (R-actinin-1), P45592 (Cofilin), Q9QXQ0 (R-actinin-4), P26473 (ADP-ribosylation factor), P26437 (ADP-ribosylation factor),   Q7TNP1 (Basigin 2), Q6P6R2 (Dihydrolipoamide dehydrogenase),   P04797 (GAPDH), Q63081 (Protein disulfide isomerase), P29457 (47 kDa heat shock protein), Q9R1J8 (Leprecan), O88638 (Putative eps protein),   Q64375 (Synaptonemal complex)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:NDPK - Interactions involving proteins containing InterPro domain IPR001564, Nucleoside diphosphate kinase, core.	taxid:10116(rat-l6)|taxid:10116(Rattus norvegicus)	-	2006/02/15	2021/11/30	rogid:PbFY2lfrty8yw40Jq7ShR7xfuV410116	rogid:z31apIIg4rXnzyHT9xKOhI2Ottw10116	intact-crc:44F3A2176D02515F|rigid:9RVm0UBcqQF4k06RGKO89Bg16Q8	false	myc tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P19357	uniprotkb:P23928	intact:EBI-915426|uniprotkb:P97900|ensembl:ENSRNOP00000023256	intact:EBI-916888|uniprotkb:Q6LDR2|ensembl:ENSRNOP00000055901	psi-mi:glut4_rat(display_long)|uniprotkb:Glucose transporter type 4, insulin-responsive(gene name synonym)|uniprotkb:Slc2a4(gene name)|psi-mi:Slc2a4(display_short)|uniprotkb:Glut4(gene name synonym)	psi-mi:cryab_rat(display_long)|uniprotkb:"Alpha(B)-crystallin"(gene name synonym)|uniprotkb:Cryab(gene name)|psi-mi:Cryab(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Foster et al. (2006)	pubmed:16396496|mint:MINT-5218203	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-921030	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2711|refseq:NP_036883.1|refseq:XP_006246658.1|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007611"(learning or memory)|go:"GO:0007614"(short-term memory)|go:"GO:0007616"(long-term memory)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010021"(amylopectin biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031550"(positive regulation of brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044381"(glucose import in response to insulin stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046323"(glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0098694"(regulation of synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0098793"(presynapse)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002441("Glucose transporter, type 4 (GLUT4)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-189200|ensembl:ENSRNOG00000017226(gene)|ensembl:ENSRNOT00000023256(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)	rgd:2414|refseq:NP_037067.1|ensembl:ENSRNOG00000010524(gene)|ensembl:ENSRNOT00000059127(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002088"(lens development in camera-type eye)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005212"(structural constituent of eye lens)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006457"(protein folding)|go:"GO:0007021"(tubulin complex assembly)|go:"GO:0007517"(muscle organ development)|go:"GO:0007568"(aging)|go:"GO:0008017"(microtubule binding)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0009986"(cell surface)|go:"GO:0010259"(multicellular organism aging)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010941"(regulation of cell death)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0030018"(Z disc)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030424"(axon)|go:"GO:0031109"(microtubule polymerization or depolymerization)|go:"GO:0031333"(negative regulation of protein-containing complex assembly)|go:"GO:0031430"(M band)|go:"GO:0031674"(I band)|go:"GO:0032355"(response to estradiol)|go:"GO:0032387"(negative regulation of intracellular transport)|go:"GO:0032432"(actin filament bundle)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043010"(camera-type eye development)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043197"(dendritic spine)|go:"GO:0043204"(perikaryon)|go:"GO:0043292"(contractile fiber)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0046872"(metal ion binding)|go:"GO:0050821"(protein stabilization)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051403"(stress-activated MAPK cascade)|go:"GO:0060561"(apoptotic process involved in morphogenesis)|go:"GO:0071480"(cellular response to gamma radiation)|go:"GO:0097060"(synaptic membrane)|go:"GO:0097512"(cardiac myofibril)|go:"GO:1905907"(negative regulation of amyloid fibril formation)|go:"GO:2000378"(negative regulation of reactive oxygen species metabolic process)|interpro:IPR001436(Alpha crystallin/Heat shock protein)|interpro:IPR002068(Heat shock protein Hsp20)|interpro:IPR003090(Alpha-crystallin, N-terminal)|interpro:IPR008978(HSP20-like chaperone)|interpro:IPR037882|mint:P23928|reactome:R-RNO-3371571	-	-	-	caution:"The participant EBI-349571(P68370) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919386(Q7TP47) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920972(Q5XIP9) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-916419(P11980) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919578(Q8R491) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920554(Q5U3Z7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920647(Q5U2X8) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920585(Q7TP24) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-779677(P05426) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-915744(P02454) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|agonist:Insulin was shown to increase or decrease GLUT4 protein interactions in specific cases.|comment:"Insulin decreased GLUT4 interactions with the following proteins: Q9ER30 (Sarcosin), P09527 (Rab-7), O88960 (N-ethylmaleimide sensitive), P09456 (PKA I regulatory subunit), P27881 (Hexokinase type II), P07872 (Acyl-coenzyme A oxidase), Q6DGF1 (Isocitrate dehydrogenase), Q9EQX9 (Ubiquitin-conjugating), Q63446 (Polyubiquitin), P24268 (Cathepsin D), Q91XW0 (Heat shock protein 86), Q5FVH0 (unknown), P58405 (Striatin 3), Q62667 (Major vault protein), Q66H50 (unknown), Q09167 (splicing factor), Q9JHU5 (Arfaptin 1)."|comment:"Insulin increased GLUT4 interaction with the following proteins:Q9Z1P2 (R-actinin-1), P45592 (Cofilin), Q9QXQ0 (R-actinin-4), P26473 (ADP-ribosylation factor), P26437 (ADP-ribosylation factor),   Q7TNP1 (Basigin 2), Q6P6R2 (Dihydrolipoamide dehydrogenase),   P04797 (GAPDH), Q63081 (Protein disulfide isomerase), P29457 (47 kDa heat shock protein), Q9R1J8 (Leprecan), O88638 (Putative eps protein),   Q64375 (Synaptonemal complex)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:NDPK - Interactions involving proteins containing InterPro domain IPR001564, Nucleoside diphosphate kinase, core.	taxid:10116(rat-l6)|taxid:10116(Rattus norvegicus)	-	2006/02/15	2021/11/30	rogid:PbFY2lfrty8yw40Jq7ShR7xfuV410116	rogid:WVFpAMy4PxYCruNm6Y0UT6+kAmo10116	intact-crc:44F3A2176D02515F|rigid:9RVm0UBcqQF4k06RGKO89Bg16Q8	false	myc tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P19357	uniprotkb:P23514	intact:EBI-915426|uniprotkb:P97900|ensembl:ENSRNOP00000023256	intact:EBI-620488|ensembl:ENSRNOP00000072797	psi-mi:glut4_rat(display_long)|uniprotkb:Glucose transporter type 4, insulin-responsive(gene name synonym)|uniprotkb:Slc2a4(gene name)|psi-mi:Slc2a4(display_short)|uniprotkb:Glut4(gene name synonym)	psi-mi:copb_rat(display_long)|uniprotkb:Beta-coat protein(gene name synonym)|uniprotkb:Copb1(gene name)|psi-mi:Copb1(display_short)|uniprotkb:Copb(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Foster et al. (2006)	pubmed:16396496|mint:MINT-5218203	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-921030	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2711|refseq:NP_036883.1|refseq:XP_006246658.1|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007611"(learning or memory)|go:"GO:0007614"(short-term memory)|go:"GO:0007616"(long-term memory)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010021"(amylopectin biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031550"(positive regulation of brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044381"(glucose import in response to insulin stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046323"(glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0098694"(regulation of synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0098793"(presynapse)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002441("Glucose transporter, type 4 (GLUT4)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-189200|ensembl:ENSRNOG00000017226(gene)|ensembl:ENSRNOT00000023256(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)	ensembl:ENSRNOG00000057623(gene)|ensembl:ENSRNOT00000083293(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005793"(endoplasmic reticulum-Golgi intermediate compartment)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005798"(Golgi-associated vesicle)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006888"(endoplasmic reticulum to Golgi vesicle-mediated transport)|go:"GO:0006890"(retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum)|go:"GO:0006891"(intra-Golgi vesicle-mediated transport)|go:"GO:0030126"(COPI vesicle coat)|go:"GO:0030137"(COPI-coated vesicle)|interpro:IPR002553(Clathrin/coatomer adaptor, adaptin-like, N-terminal)|interpro:IPR011710(Coatomer, beta subunit, C-terminal)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR016460(Coatomer, beta subunit)|interpro:IPR029446|reactome:R-RNO-6798695|reactome:R-RNO-6807878|reactome:R-RNO-6811434|refseq:XP_008757882.1|refseq:XP_008757883.1|rgd:620861|refseq:NP_542959.1	-	-	-	caution:"The participant EBI-349571(P68370) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919386(Q7TP47) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920972(Q5XIP9) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-916419(P11980) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919578(Q8R491) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920554(Q5U3Z7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920647(Q5U2X8) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920585(Q7TP24) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-779677(P05426) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-915744(P02454) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|agonist:Insulin was shown to increase or decrease GLUT4 protein interactions in specific cases.|comment:"Insulin decreased GLUT4 interactions with the following proteins: Q9ER30 (Sarcosin), P09527 (Rab-7), O88960 (N-ethylmaleimide sensitive), P09456 (PKA I regulatory subunit), P27881 (Hexokinase type II), P07872 (Acyl-coenzyme A oxidase), Q6DGF1 (Isocitrate dehydrogenase), Q9EQX9 (Ubiquitin-conjugating), Q63446 (Polyubiquitin), P24268 (Cathepsin D), Q91XW0 (Heat shock protein 86), Q5FVH0 (unknown), P58405 (Striatin 3), Q62667 (Major vault protein), Q66H50 (unknown), Q09167 (splicing factor), Q9JHU5 (Arfaptin 1)."|comment:"Insulin increased GLUT4 interaction with the following proteins:Q9Z1P2 (R-actinin-1), P45592 (Cofilin), Q9QXQ0 (R-actinin-4), P26473 (ADP-ribosylation factor), P26437 (ADP-ribosylation factor),   Q7TNP1 (Basigin 2), Q6P6R2 (Dihydrolipoamide dehydrogenase),   P04797 (GAPDH), Q63081 (Protein disulfide isomerase), P29457 (47 kDa heat shock protein), Q9R1J8 (Leprecan), O88638 (Putative eps protein),   Q64375 (Synaptonemal complex)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:NDPK - Interactions involving proteins containing InterPro domain IPR001564, Nucleoside diphosphate kinase, core.	taxid:10116(rat-l6)|taxid:10116(Rattus norvegicus)	-	2006/02/15	2021/11/30	rogid:PbFY2lfrty8yw40Jq7ShR7xfuV410116	rogid:Fv7xbRABRNgsYQtynFeHeUlwVrg10116	intact-crc:44F3A2176D02515F|rigid:9RVm0UBcqQF4k06RGKO89Bg16Q8	false	myc tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P19357	uniprotkb:P23358	intact:EBI-915426|uniprotkb:P97900|ensembl:ENSRNOP00000023256	intact:EBI-916883|ensembl:ENSRNOP00000041462	psi-mi:glut4_rat(display_long)|uniprotkb:Glucose transporter type 4, insulin-responsive(gene name synonym)|uniprotkb:Slc2a4(gene name)|psi-mi:Slc2a4(display_short)|uniprotkb:Glut4(gene name synonym)	psi-mi:rl12_rat(display_long)|uniprotkb:Rpl12(gene name)|psi-mi:Rpl12(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Foster et al. (2006)	pubmed:16396496|mint:MINT-5218203	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-921030	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2711|refseq:NP_036883.1|refseq:XP_006246658.1|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007611"(learning or memory)|go:"GO:0007614"(short-term memory)|go:"GO:0007616"(long-term memory)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010021"(amylopectin biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031550"(positive regulation of brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044381"(glucose import in response to insulin stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046323"(glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0098694"(regulation of synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0098793"(presynapse)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002441("Glucose transporter, type 4 (GLUT4)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-189200|ensembl:ENSRNOG00000017226(gene)|ensembl:ENSRNOT00000023256(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)	rgd:1565106|refseq:NP_001102668.1|refseq:XP_006227318.1|refseq:XP_006256697.1|ensembl:ENSRNOG00000028993(gene)|ensembl:ENSRNOT00000042736(transcript)|go:"GO:0003735"(structural constituent of ribosome)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006412"(translation)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015934"(large ribosomal subunit)|go:"GO:0022625"(cytosolic large ribosomal subunit)|go:"GO:0022626"(cytosolic ribosome)|go:"GO:0045901"(positive regulation of translational elongation)|go:"GO:0070180"(large ribosomal subunit rRNA binding)|interpro:IPR000911(Ribosomal protein L11)|interpro:IPR020783|interpro:IPR020784|interpro:IPR020785|interpro:IPR036769|interpro:IPR036796|mint:P23358|reactome:R-RNO-156827|reactome:R-RNO-1799339|reactome:R-RNO-6791226|reactome:R-RNO-72689|reactome:R-RNO-72706|reactome:R-RNO-975956|reactome:R-RNO-975957	-	-	-	caution:"The participant EBI-349571(P68370) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919386(Q7TP47) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920972(Q5XIP9) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-916419(P11980) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919578(Q8R491) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920554(Q5U3Z7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920647(Q5U2X8) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920585(Q7TP24) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-779677(P05426) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-915744(P02454) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|agonist:Insulin was shown to increase or decrease GLUT4 protein interactions in specific cases.|comment:"Insulin decreased GLUT4 interactions with the following proteins: Q9ER30 (Sarcosin), P09527 (Rab-7), O88960 (N-ethylmaleimide sensitive), P09456 (PKA I regulatory subunit), P27881 (Hexokinase type II), P07872 (Acyl-coenzyme A oxidase), Q6DGF1 (Isocitrate dehydrogenase), Q9EQX9 (Ubiquitin-conjugating), Q63446 (Polyubiquitin), P24268 (Cathepsin D), Q91XW0 (Heat shock protein 86), Q5FVH0 (unknown), P58405 (Striatin 3), Q62667 (Major vault protein), Q66H50 (unknown), Q09167 (splicing factor), Q9JHU5 (Arfaptin 1)."|comment:"Insulin increased GLUT4 interaction with the following proteins:Q9Z1P2 (R-actinin-1), P45592 (Cofilin), Q9QXQ0 (R-actinin-4), P26473 (ADP-ribosylation factor), P26437 (ADP-ribosylation factor),   Q7TNP1 (Basigin 2), Q6P6R2 (Dihydrolipoamide dehydrogenase),   P04797 (GAPDH), Q63081 (Protein disulfide isomerase), P29457 (47 kDa heat shock protein), Q9R1J8 (Leprecan), O88638 (Putative eps protein),   Q64375 (Synaptonemal complex)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:NDPK - Interactions involving proteins containing InterPro domain IPR001564, Nucleoside diphosphate kinase, core.	taxid:10116(rat-l6)|taxid:10116(Rattus norvegicus)	-	2006/02/15	2021/11/30	rogid:PbFY2lfrty8yw40Jq7ShR7xfuV410116	rogid:HD3+OCF6/IffH5e5AZRD235vais10116	intact-crc:44F3A2176D02515F|rigid:9RVm0UBcqQF4k06RGKO89Bg16Q8	false	myc tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P19357	uniprotkb:P62832	intact:EBI-915426|uniprotkb:P97900|ensembl:ENSRNOP00000023256	intact:EBI-353333|ensembl:ENSRNOP00000005471|uniprotkb:P23131|uniprotkb:Q29246|uniprotkb:P24048	psi-mi:glut4_rat(display_long)|uniprotkb:Glucose transporter type 4, insulin-responsive(gene name synonym)|uniprotkb:Slc2a4(gene name)|psi-mi:Slc2a4(display_short)|uniprotkb:Glut4(gene name synonym)	psi-mi:rl23_rat(display_long)|uniprotkb:Rpl23(gene name)|psi-mi:Rpl23(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Foster et al. (2006)	pubmed:16396496|mint:MINT-5218203	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-921030	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2711|refseq:NP_036883.1|refseq:XP_006246658.1|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007611"(learning or memory)|go:"GO:0007614"(short-term memory)|go:"GO:0007616"(long-term memory)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010021"(amylopectin biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031550"(positive regulation of brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044381"(glucose import in response to insulin stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046323"(glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0098694"(regulation of synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0098793"(presynapse)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002441("Glucose transporter, type 4 (GLUT4)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-189200|ensembl:ENSRNOG00000017226(gene)|ensembl:ENSRNOT00000023256(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)	ensembl:ENSRNOG00000004107(gene)|ensembl:ENSRNOT00000005471(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001223"(transcription coactivator binding)|go:"GO:0003735"(structural constituent of ribosome)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005840"(ribosome)|go:"GO:0006412"(translation)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0014069"(postsynaptic density)|go:"GO:0022625"(cytosolic large ribosomal subunit)|go:"GO:0022626"(cytosolic ribosome)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032986"(protein-DNA complex disassembly)|go:"GO:0032991"(protein-containing complex)|go:"GO:0050821"(protein stabilization)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0070180"(large ribosomal subunit rRNA binding)|go:"GO:0072717"(cellular response to actinomycin D)|go:"GO:1901798"(positive regulation of signal transduction by p53 class mediator)|go:"GO:1904667"(negative regulation of ubiquitin protein ligase activity)|go:"GO:1990948"(ubiquitin ligase inhibitor activity)|go:"GO:2000059"(negative regulation of ubiquitin-dependent protein catabolic process)|interpro:IPR000218(Ribosomal protein L14b/L23e)|interpro:IPR019972|interpro:IPR036853|mint:P62832|reactome:R-RNO-156827|reactome:R-RNO-1799339|reactome:R-RNO-6791226|reactome:R-RNO-72689|reactome:R-RNO-72706|reactome:R-RNO-975956|rgd:62067|refseq:NP_001007600.1|reactome:R-RNO-975957	-	-	-	caution:"The participant EBI-349571(P68370) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919386(Q7TP47) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920972(Q5XIP9) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-916419(P11980) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919578(Q8R491) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920554(Q5U3Z7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920647(Q5U2X8) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920585(Q7TP24) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-779677(P05426) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-915744(P02454) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|agonist:Insulin was shown to increase or decrease GLUT4 protein interactions in specific cases.|comment:"Insulin decreased GLUT4 interactions with the following proteins: Q9ER30 (Sarcosin), P09527 (Rab-7), O88960 (N-ethylmaleimide sensitive), P09456 (PKA I regulatory subunit), P27881 (Hexokinase type II), P07872 (Acyl-coenzyme A oxidase), Q6DGF1 (Isocitrate dehydrogenase), Q9EQX9 (Ubiquitin-conjugating), Q63446 (Polyubiquitin), P24268 (Cathepsin D), Q91XW0 (Heat shock protein 86), Q5FVH0 (unknown), P58405 (Striatin 3), Q62667 (Major vault protein), Q66H50 (unknown), Q09167 (splicing factor), Q9JHU5 (Arfaptin 1)."|comment:"Insulin increased GLUT4 interaction with the following proteins:Q9Z1P2 (R-actinin-1), P45592 (Cofilin), Q9QXQ0 (R-actinin-4), P26473 (ADP-ribosylation factor), P26437 (ADP-ribosylation factor),   Q7TNP1 (Basigin 2), Q6P6R2 (Dihydrolipoamide dehydrogenase),   P04797 (GAPDH), Q63081 (Protein disulfide isomerase), P29457 (47 kDa heat shock protein), Q9R1J8 (Leprecan), O88638 (Putative eps protein),   Q64375 (Synaptonemal complex)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:NDPK - Interactions involving proteins containing InterPro domain IPR001564, Nucleoside diphosphate kinase, core.	taxid:10116(rat-l6)|taxid:10116(Rattus norvegicus)	-	2006/02/15	2021/11/30	rogid:PbFY2lfrty8yw40Jq7ShR7xfuV410116	rogid:TiSVU2W4+lkwf12eb4+vG6IFlZA10116	intact-crc:44F3A2176D02515F|rigid:9RVm0UBcqQF4k06RGKO89Bg16Q8	false	myc tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P19357	uniprotkb:P21708	intact:EBI-915426|uniprotkb:P97900|ensembl:ENSRNOP00000023256	intact:EBI-916853|uniprotkb:Q4PIY8|uniprotkb:Q62686|uniprotkb:Q9JJ13|ensembl:ENSRNOP00000070784	psi-mi:glut4_rat(display_long)|uniprotkb:Glucose transporter type 4, insulin-responsive(gene name synonym)|uniprotkb:Slc2a4(gene name)|psi-mi:Slc2a4(display_short)|uniprotkb:Glut4(gene name synonym)	psi-mi:mk03_rat(display_long)|uniprotkb:Extracellular signal-regulated kinase 1(gene name synonym)|uniprotkb:Insulin-stimulated MAP2 kinase(gene name synonym)|uniprotkb:p44-ERK1(gene name synonym)|uniprotkb:ERT2(gene name synonym)|uniprotkb:MAP kinase isoform p44(gene name synonym)|uniprotkb:Microtubule-associated protein 2 kinase(gene name synonym)|uniprotkb:MNK1(gene name synonym)|uniprotkb:Mapk3(gene name)|psi-mi:Mapk3(display_short)|uniprotkb:Erk1(gene name synonym)|uniprotkb:Prkm3(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Foster et al. (2006)	pubmed:16396496|mint:MINT-5218203	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-921030	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2711|refseq:NP_036883.1|refseq:XP_006246658.1|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007611"(learning or memory)|go:"GO:0007614"(short-term memory)|go:"GO:0007616"(long-term memory)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010021"(amylopectin biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031550"(positive regulation of brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044381"(glucose import in response to insulin stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046323"(glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0098694"(regulation of synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0098793"(presynapse)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002441("Glucose transporter, type 4 (GLUT4)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-189200|ensembl:ENSRNOG00000017226(gene)|ensembl:ENSRNOT00000023256(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)	rgd:3046|refseq:NP_059043.1|dip:DIP-487N|ensembl:ENSRNOG00000053583(gene)|ensembl:ENSRNOT00000087625(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004707"(MAP kinase activity)|go:"GO:0004708"(MAP kinase kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005769"(early endosome)|go:"GO:0005770"(late endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0005925"(focal adhesion)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006915"(apoptotic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0006975"(DNA damage induced protein phosphorylation)|go:"GO:0007049"(cell cycle)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007568"(aging)|go:"GO:0009636"(response to toxic substance)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010759"(positive regulation of macrophage chemotaxis)|go:"GO:0014032"(neural crest cell development)|go:"GO:0016310"(phosphorylation)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0019369"(arachidonic acid metabolic process)|go:"GO:0019902"(phosphatase binding)|go:"GO:0030278"(regulation of ossification)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0030641"(regulation of cellular pH)|go:"GO:0030878"(thyroid gland development)|go:"GO:0031143"(pseudopodium)|go:"GO:0031281"(positive regulation of cyclase activity)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0032212"(positive regulation of telomere maintenance via telomerase)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032872"(regulation of stress-activated MAPK cascade)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033129"(positive regulation of histone phosphorylation)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0034614"(cellular response to reactive oxygen species)|go:"GO:0035066"(positive regulation of histone acetylation)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0038083"(peptidyl-tyrosine autophosphorylation)|go:"GO:0042473"(outer ear morphogenesis)|go:"GO:0042802"(identical protein binding)|go:"GO:0043330"(response to exogenous dsRNA)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046697"(decidualization)|go:"GO:0048538"(thymus development)|go:"GO:0051090"(regulation of DNA-binding transcription factor activity)|go:"GO:0051216"(cartilage development)|go:"GO:0051403"(stress-activated MAPK cascade)|go:"GO:0051493"(regulation of cytoskeleton organization)|go:"GO:0051973"(positive regulation of telomerase activity)|go:"GO:0060020"(Bergmann glial cell differentiation)|go:"GO:0060324"(face development)|go:"GO:0060425"(lung morphogenesis)|go:"GO:0060440"(trachea formation)|go:"GO:0061308"(cardiac neural crest cell development involved in heart development)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0070371"(ERK1 and ERK2 cascade)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070498"(interleukin-1-mediated signaling pathway)|go:"GO:0070849"(response to epidermal growth factor)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071276"(cellular response to cadmium ion)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0072584"(caveolin-mediated endocytosis)|go:"GO:0090170"(regulation of Golgi inheritance)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:0120041"(positive regulation of macrophage proliferation)|go:"GO:1903351"(cellular response to dopamine)|go:"GO:1904355"(positive regulation of telomere capping)|go:"GO:1904417"(positive regulation of xenophagy)|go:"GO:2000641"(regulation of early endosome to late endosome transport)|go:"GO:2000657"(negative regulation of apolipoprotein binding)|interpro:IPR000719(Protein kinase, core)|interpro:IPR003527(MAP kinase, conserved site)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR008349(ERK1/2 MAP kinase)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P21708|reactome:R-RNO-110056|reactome:R-RNO-112409|reactome:R-RNO-1169408|reactome:R-RNO-1295596|reactome:R-RNO-162658|reactome:R-RNO-170968|reactome:R-RNO-198753|reactome:R-RNO-202670|reactome:R-RNO-2029482|reactome:R-RNO-2559580|reactome:R-RNO-2559582|reactome:R-RNO-2559585|reactome:R-RNO-2871796|reactome:R-RNO-3371453|reactome:R-RNO-375165|reactome:R-RNO-445144|reactome:R-RNO-450341|reactome:R-RNO-456926|reactome:R-RNO-5654726|reactome:R-RNO-5654727|reactome:R-RNO-5654732|reactome:R-RNO-5654733|reactome:R-RNO-5663213|reactome:R-RNO-5668599|reactome:R-RNO-5673001|reactome:R-RNO-5674135|reactome:R-RNO-5674499|reactome:R-RNO-5675221|reactome:R-RNO-6811558|reactome:R-RNO-73728|reactome:R-RNO-74749|reactome:R-RNO-881907|reactome:R-RNO-8939211|reactome:R-RNO-9627069|reactome:R-RNO-982772	-	-	-	caution:"The participant EBI-349571(P68370) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919386(Q7TP47) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920972(Q5XIP9) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-916419(P11980) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919578(Q8R491) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920554(Q5U3Z7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920647(Q5U2X8) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920585(Q7TP24) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-779677(P05426) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-915744(P02454) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|agonist:Insulin was shown to increase or decrease GLUT4 protein interactions in specific cases.|comment:"Insulin decreased GLUT4 interactions with the following proteins: Q9ER30 (Sarcosin), P09527 (Rab-7), O88960 (N-ethylmaleimide sensitive), P09456 (PKA I regulatory subunit), P27881 (Hexokinase type II), P07872 (Acyl-coenzyme A oxidase), Q6DGF1 (Isocitrate dehydrogenase), Q9EQX9 (Ubiquitin-conjugating), Q63446 (Polyubiquitin), P24268 (Cathepsin D), Q91XW0 (Heat shock protein 86), Q5FVH0 (unknown), P58405 (Striatin 3), Q62667 (Major vault protein), Q66H50 (unknown), Q09167 (splicing factor), Q9JHU5 (Arfaptin 1)."|comment:"Insulin increased GLUT4 interaction with the following proteins:Q9Z1P2 (R-actinin-1), P45592 (Cofilin), Q9QXQ0 (R-actinin-4), P26473 (ADP-ribosylation factor), P26437 (ADP-ribosylation factor),   Q7TNP1 (Basigin 2), Q6P6R2 (Dihydrolipoamide dehydrogenase),   P04797 (GAPDH), Q63081 (Protein disulfide isomerase), P29457 (47 kDa heat shock protein), Q9R1J8 (Leprecan), O88638 (Putative eps protein),   Q64375 (Synaptonemal complex)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:NDPK - Interactions involving proteins containing InterPro domain IPR001564, Nucleoside diphosphate kinase, core.	taxid:10116(rat-l6)|taxid:10116(Rattus norvegicus)	-	2006/02/15	2021/11/30	rogid:PbFY2lfrty8yw40Jq7ShR7xfuV410116	rogid:GuVv68cyXYain5MyXIXpQlftLlY10116	intact-crc:44F3A2176D02515F|rigid:9RVm0UBcqQF4k06RGKO89Bg16Q8	false	myc tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P19357	uniprotkb:P21670	intact:EBI-915426|uniprotkb:P97900|ensembl:ENSRNOP00000023256	intact:EBI-916847|ensembl:ENSRNOP00000018173	psi-mi:glut4_rat(display_long)|uniprotkb:Glucose transporter type 4, insulin-responsive(gene name synonym)|uniprotkb:Slc2a4(gene name)|psi-mi:Slc2a4(display_short)|uniprotkb:Glut4(gene name synonym)	psi-mi:psa4_rat(display_long)|uniprotkb:Proteasome component C9(gene name synonym)|uniprotkb:Macropain subunit C9(gene name synonym)|uniprotkb:Multicatalytic endopeptidase complex subunit C9(gene name synonym)|uniprotkb:Proteasome subunit L(gene name synonym)|uniprotkb:Psma4(gene name)|psi-mi:Psma4(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Foster et al. (2006)	pubmed:16396496|mint:MINT-5218203	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-921030	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2711|refseq:NP_036883.1|refseq:XP_006246658.1|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007611"(learning or memory)|go:"GO:0007614"(short-term memory)|go:"GO:0007616"(long-term memory)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010021"(amylopectin biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031550"(positive regulation of brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044381"(glucose import in response to insulin stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046323"(glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0098694"(regulation of synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0098793"(presynapse)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002441("Glucose transporter, type 4 (GLUT4)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-189200|ensembl:ENSRNOG00000017226(gene)|ensembl:ENSRNOT00000023256(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)	rgd:61846|refseq:NP_058977.1|ensembl:ENSRNOG00000013493(gene)|ensembl:ENSRNOT00000018173(transcript)|go:"GO:0000502"(proteasome complex)|go:"GO:0000932"(P-body)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004298"(threonine-type endopeptidase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005839"(proteasome core complex)|go:"GO:0010499"(proteasomal ubiquitin-independent protein catabolic process)|go:"GO:0019773"(proteasome core complex, alpha-subunit complex)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|interpro:IPR000426(Proteasome alpha-subunit, conserved site)|interpro:IPR001353(20S proteasome, A and B subunits)|interpro:IPR016050(Proteasome, beta-type subunit, conserved site)|interpro:IPR023332|interpro:IPR029055|interpro:IPR034647|rcsb pdb:6EPC|rcsb pdb:6EPD|rcsb pdb:6EPE|rcsb pdb:6EPF|rcsb pdb:6TU3|reactome:R-RNO-1169091|reactome:R-RNO-1234176|reactome:R-RNO-1236978|reactome:R-RNO-174084|reactome:R-RNO-174154|reactome:R-RNO-174178|reactome:R-RNO-174184|reactome:R-RNO-187577|reactome:R-RNO-195253|reactome:R-RNO-2467813|reactome:R-RNO-349425|reactome:R-RNO-350562|reactome:R-RNO-382556|reactome:R-RNO-450408|reactome:R-RNO-4608870|reactome:R-RNO-4641257|reactome:R-RNO-4641258|reactome:R-RNO-5358346|reactome:R-RNO-5607761|reactome:R-RNO-5610780|reactome:R-RNO-5610785|reactome:R-RNO-5632684|reactome:R-RNO-5658442|reactome:R-RNO-5668541|reactome:R-RNO-5676590|reactome:R-RNO-5687128|reactome:R-RNO-5689603|reactome:R-RNO-5689880|reactome:R-RNO-68827|reactome:R-RNO-68949|reactome:R-RNO-69017|reactome:R-RNO-69481|reactome:R-RNO-69601|reactome:R-RNO-75815|reactome:R-RNO-8852276|reactome:R-RNO-8854050|reactome:R-RNO-8932339|reactome:R-RNO-8939236|reactome:R-RNO-8941858|reactome:R-RNO-8948751|reactome:R-RNO-8951664|reactome:R-RNO-983168	-	-	-	caution:"The participant EBI-349571(P68370) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919386(Q7TP47) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920972(Q5XIP9) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-916419(P11980) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919578(Q8R491) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920554(Q5U3Z7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920647(Q5U2X8) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920585(Q7TP24) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-779677(P05426) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-915744(P02454) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|agonist:Insulin was shown to increase or decrease GLUT4 protein interactions in specific cases.|comment:"Insulin decreased GLUT4 interactions with the following proteins: Q9ER30 (Sarcosin), P09527 (Rab-7), O88960 (N-ethylmaleimide sensitive), P09456 (PKA I regulatory subunit), P27881 (Hexokinase type II), P07872 (Acyl-coenzyme A oxidase), Q6DGF1 (Isocitrate dehydrogenase), Q9EQX9 (Ubiquitin-conjugating), Q63446 (Polyubiquitin), P24268 (Cathepsin D), Q91XW0 (Heat shock protein 86), Q5FVH0 (unknown), P58405 (Striatin 3), Q62667 (Major vault protein), Q66H50 (unknown), Q09167 (splicing factor), Q9JHU5 (Arfaptin 1)."|comment:"Insulin increased GLUT4 interaction with the following proteins:Q9Z1P2 (R-actinin-1), P45592 (Cofilin), Q9QXQ0 (R-actinin-4), P26473 (ADP-ribosylation factor), P26437 (ADP-ribosylation factor),   Q7TNP1 (Basigin 2), Q6P6R2 (Dihydrolipoamide dehydrogenase),   P04797 (GAPDH), Q63081 (Protein disulfide isomerase), P29457 (47 kDa heat shock protein), Q9R1J8 (Leprecan), O88638 (Putative eps protein),   Q64375 (Synaptonemal complex)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:NDPK - Interactions involving proteins containing InterPro domain IPR001564, Nucleoside diphosphate kinase, core.	taxid:10116(rat-l6)|taxid:10116(Rattus norvegicus)	-	2006/02/15	2021/11/30	rogid:PbFY2lfrty8yw40Jq7ShR7xfuV410116	rogid:7fTJxarnOfFJ6AdMuJXQsUIz4eA10116	intact-crc:44F3A2176D02515F|rigid:9RVm0UBcqQF4k06RGKO89Bg16Q8	false	myc tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P19357	uniprotkb:P21533	intact:EBI-915426|uniprotkb:P97900|ensembl:ENSRNOP00000023256	intact:EBI-916839|uniprotkb:Q4QRA9|uniprotkb:Q64624|uniprotkb:Q68G26|ensembl:ENSRNOP00000038065	psi-mi:glut4_rat(display_long)|uniprotkb:Glucose transporter type 4, insulin-responsive(gene name synonym)|uniprotkb:Slc2a4(gene name)|psi-mi:Slc2a4(display_short)|uniprotkb:Glut4(gene name synonym)	psi-mi:rl6_rat(display_long)|uniprotkb:Neoplasm-related protein C140(gene name synonym)|uniprotkb:Rpl6(gene name)|psi-mi:Rpl6(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Foster et al. (2006)	pubmed:16396496|mint:MINT-5218203	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-921030	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2711|refseq:NP_036883.1|refseq:XP_006246658.1|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007611"(learning or memory)|go:"GO:0007614"(short-term memory)|go:"GO:0007616"(long-term memory)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010021"(amylopectin biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031550"(positive regulation of brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044381"(glucose import in response to insulin stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046323"(glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0098694"(regulation of synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0098793"(presynapse)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002441("Glucose transporter, type 4 (GLUT4)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-189200|ensembl:ENSRNOG00000017226(gene)|ensembl:ENSRNOT00000023256(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)	rgd:619826|refseq:NP_446423.2|refseq:XP_006249440.1|ensembl:ENSRNOG00000025936(gene)|ensembl:ENSRNOT00000034951(transcript)|go:"GO:0000027"(ribosomal large subunit assembly)|go:"GO:0000049"(tRNA binding)|go:"GO:0002181"(cytoplasmic translation)|go:"GO:0003723"(RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0003735"(structural constituent of ribosome)|go:"GO:0005634"(nucleus)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0014069"(postsynaptic density)|go:"GO:0022625"(cytosolic large ribosomal subunit)|go:"GO:0022626"(cytosolic ribosome)|go:"GO:0031672"(A band)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042788"(polysomal ribosome)|go:"GO:0045202"(synapse)|go:"GO:1990932"(5.8S rRNA binding)|interpro:IPR000915(Ribosomal protein L6E)|interpro:IPR005568(Ribosomal protein L6, N-terminal)|interpro:IPR008991(Translation protein SH3-like)|interpro:IPR014722(Translation protein SH3-like, subgroup)|interpro:IPR041997|mint:P21533|reactome:R-RNO-156827|reactome:R-RNO-1799339|reactome:R-RNO-6791226|reactome:R-RNO-72689|reactome:R-RNO-72706|reactome:R-RNO-975956|reactome:R-RNO-975957	-	-	-	caution:"The participant EBI-349571(P68370) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919386(Q7TP47) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920972(Q5XIP9) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-916419(P11980) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919578(Q8R491) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920554(Q5U3Z7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920647(Q5U2X8) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920585(Q7TP24) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-779677(P05426) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-915744(P02454) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|agonist:Insulin was shown to increase or decrease GLUT4 protein interactions in specific cases.|comment:"Insulin decreased GLUT4 interactions with the following proteins: Q9ER30 (Sarcosin), P09527 (Rab-7), O88960 (N-ethylmaleimide sensitive), P09456 (PKA I regulatory subunit), P27881 (Hexokinase type II), P07872 (Acyl-coenzyme A oxidase), Q6DGF1 (Isocitrate dehydrogenase), Q9EQX9 (Ubiquitin-conjugating), Q63446 (Polyubiquitin), P24268 (Cathepsin D), Q91XW0 (Heat shock protein 86), Q5FVH0 (unknown), P58405 (Striatin 3), Q62667 (Major vault protein), Q66H50 (unknown), Q09167 (splicing factor), Q9JHU5 (Arfaptin 1)."|comment:"Insulin increased GLUT4 interaction with the following proteins:Q9Z1P2 (R-actinin-1), P45592 (Cofilin), Q9QXQ0 (R-actinin-4), P26473 (ADP-ribosylation factor), P26437 (ADP-ribosylation factor),   Q7TNP1 (Basigin 2), Q6P6R2 (Dihydrolipoamide dehydrogenase),   P04797 (GAPDH), Q63081 (Protein disulfide isomerase), P29457 (47 kDa heat shock protein), Q9R1J8 (Leprecan), O88638 (Putative eps protein),   Q64375 (Synaptonemal complex)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:NDPK - Interactions involving proteins containing InterPro domain IPR001564, Nucleoside diphosphate kinase, core.	taxid:10116(rat-l6)|taxid:10116(Rattus norvegicus)	-	2006/02/15	2021/11/30	rogid:PbFY2lfrty8yw40Jq7ShR7xfuV410116	rogid:+Bu8WYfbZdOhyyKpe04yNgrRKkU10116	intact-crc:44F3A2176D02515F|rigid:9RVm0UBcqQF4k06RGKO89Bg16Q8	false	myc tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P19357	uniprotkb:P21213	intact:EBI-915426|uniprotkb:P97900|ensembl:ENSRNOP00000023256	intact:EBI-916828|uniprotkb:Q5EBB8|ensembl:ENSRNOP00000006971	psi-mi:glut4_rat(display_long)|uniprotkb:Glucose transporter type 4, insulin-responsive(gene name synonym)|uniprotkb:Slc2a4(gene name)|psi-mi:Slc2a4(display_short)|uniprotkb:Glut4(gene name synonym)	psi-mi:huth_rat(display_long)|uniprotkb:Hal(gene name)|psi-mi:Hal(display_short)|uniprotkb:Huth(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Foster et al. (2006)	pubmed:16396496|mint:MINT-5218203	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-921030	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2711|refseq:NP_036883.1|refseq:XP_006246658.1|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007611"(learning or memory)|go:"GO:0007614"(short-term memory)|go:"GO:0007616"(long-term memory)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010021"(amylopectin biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031550"(positive regulation of brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044381"(glucose import in response to insulin stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046323"(glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0098694"(regulation of synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0098793"(presynapse)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002441("Glucose transporter, type 4 (GLUT4)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-189200|ensembl:ENSRNOG00000017226(gene)|ensembl:ENSRNOT00000023256(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)	rgd:68363|refseq:NP_058855.1|dip:DIP-37290N|ensembl:ENSRNOG00000004502(gene)|ensembl:ENSRNOT00000006971(transcript)|go:"GO:0004397"(histidine ammonia-lyase activity)|go:"GO:0005829"(cytosol)|go:"GO:0006547"(histidine metabolic process)|go:"GO:0006548"(histidine catabolic process)|go:"GO:0016841"(ammonia-lyase activity)|go:"GO:0019556"(histidine catabolic process to glutamate and formamide)|go:"GO:0019557"(histidine catabolic process to glutamate and formate)|interpro:IPR001106(Phenylalanine/histidine ammonia-lyase)|interpro:IPR005921(Histidine ammonia-lyase)|interpro:IPR008948(L-Aspartase-like)|interpro:IPR021922|interpro:IPR022313|interpro:IPR024083|reactome:R-RNO-70921	-	-	-	caution:"The participant EBI-349571(P68370) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919386(Q7TP47) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920972(Q5XIP9) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-916419(P11980) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919578(Q8R491) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920554(Q5U3Z7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920647(Q5U2X8) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920585(Q7TP24) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-779677(P05426) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-915744(P02454) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|agonist:Insulin was shown to increase or decrease GLUT4 protein interactions in specific cases.|comment:"Insulin decreased GLUT4 interactions with the following proteins: Q9ER30 (Sarcosin), P09527 (Rab-7), O88960 (N-ethylmaleimide sensitive), P09456 (PKA I regulatory subunit), P27881 (Hexokinase type II), P07872 (Acyl-coenzyme A oxidase), Q6DGF1 (Isocitrate dehydrogenase), Q9EQX9 (Ubiquitin-conjugating), Q63446 (Polyubiquitin), P24268 (Cathepsin D), Q91XW0 (Heat shock protein 86), Q5FVH0 (unknown), P58405 (Striatin 3), Q62667 (Major vault protein), Q66H50 (unknown), Q09167 (splicing factor), Q9JHU5 (Arfaptin 1)."|comment:"Insulin increased GLUT4 interaction with the following proteins:Q9Z1P2 (R-actinin-1), P45592 (Cofilin), Q9QXQ0 (R-actinin-4), P26473 (ADP-ribosylation factor), P26437 (ADP-ribosylation factor),   Q7TNP1 (Basigin 2), Q6P6R2 (Dihydrolipoamide dehydrogenase),   P04797 (GAPDH), Q63081 (Protein disulfide isomerase), P29457 (47 kDa heat shock protein), Q9R1J8 (Leprecan), O88638 (Putative eps protein),   Q64375 (Synaptonemal complex)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:NDPK - Interactions involving proteins containing InterPro domain IPR001564, Nucleoside diphosphate kinase, core.	taxid:10116(rat-l6)|taxid:10116(Rattus norvegicus)	-	2006/02/15	2021/11/30	rogid:PbFY2lfrty8yw40Jq7ShR7xfuV410116	rogid:2551c93IPKtbF1db9g7R8K8xERc10116	intact-crc:44F3A2176D02515F|rigid:9RVm0UBcqQF4k06RGKO89Bg16Q8	false	myc tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P19357	uniprotkb:P20417	intact:EBI-915426|uniprotkb:P97900|ensembl:ENSRNOP00000023256	intact:EBI-916819|ensembl:ENSRNOP00000014309	psi-mi:glut4_rat(display_long)|uniprotkb:Glucose transporter type 4, insulin-responsive(gene name synonym)|uniprotkb:Slc2a4(gene name)|psi-mi:Slc2a4(display_short)|uniprotkb:Glut4(gene name synonym)	psi-mi:ptn1_rat(display_long)|uniprotkb:Protein-tyrosine phosphatase 1B(gene name synonym)|uniprotkb:Ptpn1(gene name)|psi-mi:Ptpn1(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Foster et al. (2006)	pubmed:16396496|mint:MINT-5218203	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-921030	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2711|refseq:NP_036883.1|refseq:XP_006246658.1|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007611"(learning or memory)|go:"GO:0007614"(short-term memory)|go:"GO:0007616"(long-term memory)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010021"(amylopectin biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031550"(positive regulation of brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044381"(glucose import in response to insulin stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046323"(glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0098694"(regulation of synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0098793"(presynapse)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002441("Glucose transporter, type 4 (GLUT4)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-189200|ensembl:ENSRNOG00000017226(gene)|ensembl:ENSRNOT00000023256(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)	rgd:61965|refseq:NP_036769.1|ensembl:ENSRNOG00000010574(gene)|ensembl:ENSRNOT00000014309(transcript)|go:"GO:0004725"(protein tyrosine phosphatase activity)|go:"GO:0005158"(insulin receptor binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005769"(early endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0007257"(obsolete activation of JUN kinase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0009966"(regulation of signal transduction)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030061"(mitochondrial crista)|go:"GO:0030100"(regulation of endocytosis)|go:"GO:0030948"(negative regulation of vascular endothelial growth factor receptor signaling pathway)|go:"GO:0030968"(endoplasmic reticulum unfolded protein response)|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0031225"(anchored component of membrane)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033157"(regulation of intracellular protein transport)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0035335"(peptidyl-tyrosine dephosphorylation)|go:"GO:0035791"(platelet-derived growth factor receptor-beta signaling pathway)|go:"GO:0036498"(IRE1-mediated unfolded protein response)|go:"GO:0043407"(negative regulation of MAP kinase activity)|go:"GO:0046626"(regulation of insulin receptor signaling pathway)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0051721"(protein phosphatase 2A binding)|go:"GO:0061098"(positive regulation of protein tyrosine kinase activity)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0097443"(sorting endosome)|go:"GO:0098554"(cytoplasmic side of endoplasmic reticulum membrane)|go:"GO:1902202"(regulation of hepatocyte growth factor receptor signaling pathway)|go:"GO:1902236"(negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway)|go:"GO:1903898"(negative regulation of PERK-mediated unfolded protein response)|go:"GO:1990264"(peptidyl-tyrosine dephosphorylation involved in inactivation of protein kinase activity)|go:"GO:2000646"(positive regulation of receptor catabolic process)|interpro:IPR000242(Protein-tyrosine phosphatase, receptor/non-receptor type)|interpro:IPR000387(Protein-tyrosine phosphatase)|interpro:IPR003595(Protein-tyrosine phosphatase, catalytic)|interpro:IPR012265(Protein-tyrosine phosphatase, non-receptor type-1, -2)|interpro:IPR016130(Protein-tyrosine phosphatase, active site)|interpro:IPR029021|mint:P20417|reactome:R-RNO-354192|reactome:R-RNO-6807004|reactome:R-RNO-8849472|reactome:R-RNO-912694|reactome:R-RNO-982772	-	-	-	caution:"The participant EBI-349571(P68370) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919386(Q7TP47) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920972(Q5XIP9) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-916419(P11980) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919578(Q8R491) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920554(Q5U3Z7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920647(Q5U2X8) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920585(Q7TP24) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-779677(P05426) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-915744(P02454) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|agonist:Insulin was shown to increase or decrease GLUT4 protein interactions in specific cases.|comment:"Insulin decreased GLUT4 interactions with the following proteins: Q9ER30 (Sarcosin), P09527 (Rab-7), O88960 (N-ethylmaleimide sensitive), P09456 (PKA I regulatory subunit), P27881 (Hexokinase type II), P07872 (Acyl-coenzyme A oxidase), Q6DGF1 (Isocitrate dehydrogenase), Q9EQX9 (Ubiquitin-conjugating), Q63446 (Polyubiquitin), P24268 (Cathepsin D), Q91XW0 (Heat shock protein 86), Q5FVH0 (unknown), P58405 (Striatin 3), Q62667 (Major vault protein), Q66H50 (unknown), Q09167 (splicing factor), Q9JHU5 (Arfaptin 1)."|comment:"Insulin increased GLUT4 interaction with the following proteins:Q9Z1P2 (R-actinin-1), P45592 (Cofilin), Q9QXQ0 (R-actinin-4), P26473 (ADP-ribosylation factor), P26437 (ADP-ribosylation factor),   Q7TNP1 (Basigin 2), Q6P6R2 (Dihydrolipoamide dehydrogenase),   P04797 (GAPDH), Q63081 (Protein disulfide isomerase), P29457 (47 kDa heat shock protein), Q9R1J8 (Leprecan), O88638 (Putative eps protein),   Q64375 (Synaptonemal complex)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:NDPK - Interactions involving proteins containing InterPro domain IPR001564, Nucleoside diphosphate kinase, core.	taxid:10116(rat-l6)|taxid:10116(Rattus norvegicus)	-	2006/02/15	2021/11/30	rogid:PbFY2lfrty8yw40Jq7ShR7xfuV410116	rogid:Y6vdwdAGHw4KD4ivLGdvOfrXTK010116	intact-crc:44F3A2176D02515F|rigid:9RVm0UBcqQF4k06RGKO89Bg16Q8	false	myc tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P19357	uniprotkb:P63074	intact:EBI-915426|uniprotkb:P97900|ensembl:ENSRNOP00000023256	intact:EBI-916813|uniprotkb:P20415|ensembl:ENSRNOP00000073799	psi-mi:glut4_rat(display_long)|uniprotkb:Glucose transporter type 4, insulin-responsive(gene name synonym)|uniprotkb:Slc2a4(gene name)|psi-mi:Slc2a4(display_short)|uniprotkb:Glut4(gene name synonym)	psi-mi:if4e_rat(display_long)|uniprotkb:mRNA cap-binding protein(gene name synonym)|uniprotkb:eIF-4F 25 kDa subunit(gene name synonym)|uniprotkb:Eif4e(gene name)|psi-mi:Eif4e(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Foster et al. (2006)	pubmed:16396496|mint:MINT-5218203	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-921030	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2711|refseq:NP_036883.1|refseq:XP_006246658.1|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007611"(learning or memory)|go:"GO:0007614"(short-term memory)|go:"GO:0007616"(long-term memory)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010021"(amylopectin biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031550"(positive regulation of brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044381"(glucose import in response to insulin stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046323"(glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0098694"(regulation of synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0098793"(presynapse)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002441("Glucose transporter, type 4 (GLUT4)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-189200|ensembl:ENSRNOG00000017226(gene)|ensembl:ENSRNOT00000023256(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)	rgd:69647|refseq:NP_446426.1|refseq:XP_008759710.1|ensembl:ENSRNOG00000052343(gene)|ensembl:ENSRNOT00000090526(transcript)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0000340"(RNA 7-methylguanosine cap binding)|go:"GO:0000932"(P-body)|go:"GO:0001662"(behavioral fear response)|go:"GO:0003743"(translation initiation factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005845"(mRNA cap binding complex)|go:"GO:0006417"(regulation of translation)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0016281"(eukaryotic translation initiation factor 4F complex)|go:"GO:0016442"(RISC complex)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0019899"(enzyme binding)|go:"GO:0030324"(lung development)|go:"GO:0031370"(eukaryotic initiation factor 4G binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033391"(chromatoid body)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0045931"(positive regulation of mitotic cell cycle)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0071549"(cellular response to dexamethasone stimulus)|go:"GO:0098794"(postsynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:0099578"(regulation of translation at postsynapse, modulating synaptic transmission)|go:"GO:0140297"(DNA-binding transcription factor binding)|interpro:IPR001040("Eukaryotic translation initiation factor 4E (eIF-4E)")|interpro:IPR019770|interpro:IPR023398|reactome:R-RNO-1169408|reactome:R-RNO-156827|reactome:R-RNO-159227|reactome:R-RNO-159230|reactome:R-RNO-159231|reactome:R-RNO-166208|reactome:R-RNO-429947|reactome:R-RNO-72649|reactome:R-RNO-72662|reactome:R-RNO-72702|reactome:R-RNO-72706	-	-	-	caution:"The participant EBI-349571(P68370) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919386(Q7TP47) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920972(Q5XIP9) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-916419(P11980) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919578(Q8R491) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920554(Q5U3Z7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920647(Q5U2X8) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920585(Q7TP24) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-779677(P05426) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-915744(P02454) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|agonist:Insulin was shown to increase or decrease GLUT4 protein interactions in specific cases.|comment:"Insulin decreased GLUT4 interactions with the following proteins: Q9ER30 (Sarcosin), P09527 (Rab-7), O88960 (N-ethylmaleimide sensitive), P09456 (PKA I regulatory subunit), P27881 (Hexokinase type II), P07872 (Acyl-coenzyme A oxidase), Q6DGF1 (Isocitrate dehydrogenase), Q9EQX9 (Ubiquitin-conjugating), Q63446 (Polyubiquitin), P24268 (Cathepsin D), Q91XW0 (Heat shock protein 86), Q5FVH0 (unknown), P58405 (Striatin 3), Q62667 (Major vault protein), Q66H50 (unknown), Q09167 (splicing factor), Q9JHU5 (Arfaptin 1)."|comment:"Insulin increased GLUT4 interaction with the following proteins:Q9Z1P2 (R-actinin-1), P45592 (Cofilin), Q9QXQ0 (R-actinin-4), P26473 (ADP-ribosylation factor), P26437 (ADP-ribosylation factor),   Q7TNP1 (Basigin 2), Q6P6R2 (Dihydrolipoamide dehydrogenase),   P04797 (GAPDH), Q63081 (Protein disulfide isomerase), P29457 (47 kDa heat shock protein), Q9R1J8 (Leprecan), O88638 (Putative eps protein),   Q64375 (Synaptonemal complex)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:NDPK - Interactions involving proteins containing InterPro domain IPR001564, Nucleoside diphosphate kinase, core.	taxid:10116(rat-l6)|taxid:10116(Rattus norvegicus)	-	2006/02/15	2021/11/30	rogid:PbFY2lfrty8yw40Jq7ShR7xfuV410116	rogid:DnMmfgiMq6RHbSuRPwy/TaoeySU10116	intact-crc:44F3A2176D02515F|rigid:9RVm0UBcqQF4k06RGKO89Bg16Q8	false	myc tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P19357	uniprotkb:P84092	intact:EBI-915426|uniprotkb:P97900|ensembl:ENSRNOP00000023256	intact:EBI-297693|uniprotkb:P53679|uniprotkb:P20172|ensembl:ENSRNOP00000070202	psi-mi:glut4_rat(display_long)|uniprotkb:Glucose transporter type 4, insulin-responsive(gene name synonym)|uniprotkb:Slc2a4(gene name)|psi-mi:Slc2a4(display_short)|uniprotkb:Glut4(gene name synonym)	psi-mi:ap2m1_rat(display_long)|uniprotkb:Adaptor protein complex AP-2 subunit mu(gene name synonym)|uniprotkb:AP-2 mu chain(gene name synonym)|uniprotkb:Ap2m1(gene name)|psi-mi:Ap2m1(display_short)|uniprotkb:Mu2-adaptin(gene name synonym)|uniprotkb:Plasma membrane adaptor AP-2 50 kDa protein(gene name synonym)|uniprotkb:Clathrin coat assembly protein AP50(gene name synonym)|uniprotkb:Clathrin coat-associated protein AP50(gene name synonym)|uniprotkb:Clathrin assembly protein complex 2 mu medium chain(gene name synonym)|uniprotkb:Adaptor-related protein complex 2 subunit mu(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Foster et al. (2006)	pubmed:16396496|mint:MINT-5218203	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-921030	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2711|refseq:NP_036883.1|refseq:XP_006246658.1|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007611"(learning or memory)|go:"GO:0007614"(short-term memory)|go:"GO:0007616"(long-term memory)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010021"(amylopectin biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031550"(positive regulation of brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044381"(glucose import in response to insulin stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046323"(glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0098694"(regulation of synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0098793"(presynapse)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002441("Glucose transporter, type 4 (GLUT4)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-189200|ensembl:ENSRNOG00000017226(gene)|ensembl:ENSRNOT00000023256(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)	go:"GO:0098794"(postsynapse)|go:"GO:0098884"(postsynaptic neurotransmitter receptor internalization)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1900244"(positive regulation of synaptic vesicle endocytosis)|go:"GO:1903077"(negative regulation of protein localization to plasma membrane)|interpro:IPR001392(Clathrin adaptor, mu subunit)|interpro:IPR011012(Longin-like)|interpro:IPR018240|interpro:IPR022775|interpro:IPR028565|interpro:IPR036168|interpro:IPR043512|interpro:IPR043532|mint:P84092|rcsb pdb:1BW8|rcsb pdb:1BXX|rcsb pdb:1HES|rcsb pdb:1I31|rcsb pdb:2BP5|rcsb pdb:2JKR|rcsb pdb:2JKT|rcsb pdb:2PR9|rcsb pdb:2VGL|rcsb pdb:2XA7|rcsb pdb:3H85|rcsb pdb:3ML6|rcsb pdb:4UQI|rcsb pdb:5C7Z|rcsb pdb:5FPI|rcsb pdb:5WRK|go:"GO:0097718"(disordered domain specific binding)|rcsb pdb:5WRL|rcsb pdb:5WRM|rcsb pdb:6QH5|rcsb pdb:6QH6|rcsb pdb:6RH6|rcsb pdb:6YAE|rcsb pdb:6YAF|rcsb pdb:6YAH|reactome:R-RNO-177504|reactome:R-RNO-190873|reactome:R-RNO-196025|reactome:R-RNO-2132295|reactome:R-RNO-416993|reactome:R-RNO-437239|reactome:R-RNO-5099900|reactome:R-RNO-5140745|reactome:R-RNO-8856825|reactome:R-RNO-8856828|reactome:R-RNO-8866427|reactome:R-RNO-8964038|ensembl:ENSRNOG00000001709(gene)|ensembl:ENSRNOT00000088821(transcript)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0005048"(signal sequence binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006897"(endocytosis)|go:"GO:0006900"(vesicle budding from membrane)|go:"GO:0008289"(lipid binding)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0030122"(AP-2 adaptor complex)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031623"(receptor internalization)|go:"GO:0035615"(clathrin adaptor activity)|go:"GO:0043195"(terminal bouton)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0048488"(synaptic vesicle endocytosis)|go:"GO:0050750"(low-density lipoprotein particle receptor binding)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0072583"(clathrin-dependent endocytosis)|go:"GO:0097494"(regulation of vesicle size)|rgd:620135|refseq:NP_446289.1|dip:DIP-29761N	-	-	-	caution:"The participant EBI-349571(P68370) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919386(Q7TP47) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920972(Q5XIP9) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-916419(P11980) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919578(Q8R491) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920554(Q5U3Z7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920647(Q5U2X8) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920585(Q7TP24) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-779677(P05426) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-915744(P02454) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|agonist:Insulin was shown to increase or decrease GLUT4 protein interactions in specific cases.|comment:"Insulin decreased GLUT4 interactions with the following proteins: Q9ER30 (Sarcosin), P09527 (Rab-7), O88960 (N-ethylmaleimide sensitive), P09456 (PKA I regulatory subunit), P27881 (Hexokinase type II), P07872 (Acyl-coenzyme A oxidase), Q6DGF1 (Isocitrate dehydrogenase), Q9EQX9 (Ubiquitin-conjugating), Q63446 (Polyubiquitin), P24268 (Cathepsin D), Q91XW0 (Heat shock protein 86), Q5FVH0 (unknown), P58405 (Striatin 3), Q62667 (Major vault protein), Q66H50 (unknown), Q09167 (splicing factor), Q9JHU5 (Arfaptin 1)."|comment:"Insulin increased GLUT4 interaction with the following proteins:Q9Z1P2 (R-actinin-1), P45592 (Cofilin), Q9QXQ0 (R-actinin-4), P26473 (ADP-ribosylation factor), P26437 (ADP-ribosylation factor),   Q7TNP1 (Basigin 2), Q6P6R2 (Dihydrolipoamide dehydrogenase),   P04797 (GAPDH), Q63081 (Protein disulfide isomerase), P29457 (47 kDa heat shock protein), Q9R1J8 (Leprecan), O88638 (Putative eps protein),   Q64375 (Synaptonemal complex)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:NDPK - Interactions involving proteins containing InterPro domain IPR001564, Nucleoside diphosphate kinase, core.	taxid:10116(rat-l6)|taxid:10116(Rattus norvegicus)	-	2006/02/15	2021/11/30	rogid:PbFY2lfrty8yw40Jq7ShR7xfuV410116	rogid:AyJEJTqzHtIRWEnMGBzLQP3H5lA10116	intact-crc:44F3A2176D02515F|rigid:9RVm0UBcqQF4k06RGKO89Bg16Q8	false	myc tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P19357	uniprotkb:P20069	intact:EBI-915426|uniprotkb:P97900|ensembl:ENSRNOP00000023256	intact:EBI-916791	psi-mi:glut4_rat(display_long)|uniprotkb:Glucose transporter type 4, insulin-responsive(gene name synonym)|uniprotkb:Slc2a4(gene name)|psi-mi:Slc2a4(display_short)|uniprotkb:Glut4(gene name synonym)	psi-mi:mppa_rat(display_long)|uniprotkb:Alpha-MPP(gene name synonym)|uniprotkb:P-55(gene name synonym)|uniprotkb:Pmpca(gene name)|psi-mi:Pmpca(display_short)|uniprotkb:Mppa(gene name synonym)|uniprotkb:Inactive zinc metalloprotease alpha(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Foster et al. (2006)	pubmed:16396496|mint:MINT-5218203	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-921030	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2711|refseq:NP_036883.1|refseq:XP_006246658.1|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007611"(learning or memory)|go:"GO:0007614"(short-term memory)|go:"GO:0007616"(long-term memory)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010021"(amylopectin biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031550"(positive regulation of brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044381"(glucose import in response to insulin stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046323"(glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0098694"(regulation of synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0098793"(presynapse)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002441("Glucose transporter, type 4 (GLUT4)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-189200|ensembl:ENSRNOG00000017226(gene)|ensembl:ENSRNOT00000023256(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)	interpro:IPR011249(Metalloenzyme, LuxS/M16 peptidase-like, metal-binding)|interpro:IPR011765(Peptidase M16, N-terminal)|interpro:IPR001431(Peptidase M16, zinc-binding site)|interpro:IPR007863(Peptidase M16, C-terminal)|rgd:727897|interpro:IPR037715|reactome:R-RNO-8949664|go:"GO:0004175"(endopeptidase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0006508"(proteolysis)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0046872"(metal ion binding)	-	-	-	caution:"The participant EBI-349571(P68370) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919386(Q7TP47) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920972(Q5XIP9) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-916419(P11980) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919578(Q8R491) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920554(Q5U3Z7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920647(Q5U2X8) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920585(Q7TP24) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-779677(P05426) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-915744(P02454) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|agonist:Insulin was shown to increase or decrease GLUT4 protein interactions in specific cases.|comment:"Insulin decreased GLUT4 interactions with the following proteins: Q9ER30 (Sarcosin), P09527 (Rab-7), O88960 (N-ethylmaleimide sensitive), P09456 (PKA I regulatory subunit), P27881 (Hexokinase type II), P07872 (Acyl-coenzyme A oxidase), Q6DGF1 (Isocitrate dehydrogenase), Q9EQX9 (Ubiquitin-conjugating), Q63446 (Polyubiquitin), P24268 (Cathepsin D), Q91XW0 (Heat shock protein 86), Q5FVH0 (unknown), P58405 (Striatin 3), Q62667 (Major vault protein), Q66H50 (unknown), Q09167 (splicing factor), Q9JHU5 (Arfaptin 1)."|comment:"Insulin increased GLUT4 interaction with the following proteins:Q9Z1P2 (R-actinin-1), P45592 (Cofilin), Q9QXQ0 (R-actinin-4), P26473 (ADP-ribosylation factor), P26437 (ADP-ribosylation factor),   Q7TNP1 (Basigin 2), Q6P6R2 (Dihydrolipoamide dehydrogenase),   P04797 (GAPDH), Q63081 (Protein disulfide isomerase), P29457 (47 kDa heat shock protein), Q9R1J8 (Leprecan), O88638 (Putative eps protein),   Q64375 (Synaptonemal complex)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:NDPK - Interactions involving proteins containing InterPro domain IPR001564, Nucleoside diphosphate kinase, core.	taxid:10116(rat-l6)|taxid:10116(Rattus norvegicus)	-	2006/02/15	2021/11/30	rogid:PbFY2lfrty8yw40Jq7ShR7xfuV410116	rogid:byVW2j/MsirXdQpmpCSvbUes/P810116	intact-crc:44F3A2176D02515F|rigid:9RVm0UBcqQF4k06RGKO89Bg16Q8	false	myc tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P19357	uniprotkb:P19945	intact:EBI-915426|uniprotkb:P97900|ensembl:ENSRNOP00000023256	intact:EBI-916785|ensembl:ENSRNOP00000001518	psi-mi:glut4_rat(display_long)|uniprotkb:Glucose transporter type 4, insulin-responsive(gene name synonym)|uniprotkb:Slc2a4(gene name)|psi-mi:Slc2a4(display_short)|uniprotkb:Glut4(gene name synonym)	psi-mi:rla0_rat(display_long)|uniprotkb:60S ribosomal protein L10E(gene name synonym)|uniprotkb:Rplp0(gene name)|psi-mi:Rplp0(display_short)|uniprotkb:Arbp(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Foster et al. (2006)	pubmed:16396496|mint:MINT-5218203	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-921030	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2711|refseq:NP_036883.1|refseq:XP_006246658.1|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007611"(learning or memory)|go:"GO:0007614"(short-term memory)|go:"GO:0007616"(long-term memory)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010021"(amylopectin biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031550"(positive regulation of brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044381"(glucose import in response to insulin stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046323"(glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0098694"(regulation of synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0098793"(presynapse)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002441("Glucose transporter, type 4 (GLUT4)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-189200|ensembl:ENSRNOG00000017226(gene)|ensembl:ENSRNOT00000023256(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)	rgd:621247|refseq:NP_071797.1|ensembl:ENSRNOG00000001148(gene)|ensembl:ENSRNOT00000001518(transcript)|go:"GO:0000027"(ribosomal large subunit assembly)|go:"GO:0002181"(cytoplasmic translation)|go:"GO:0003735"(structural constituent of ribosome)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0007595"(lactation)|go:"GO:0010269"(response to selenium ion)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0022625"(cytosolic large ribosomal subunit)|go:"GO:0022626"(cytosolic ribosome)|go:"GO:0030425"(dendrite)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042277"(peptide binding)|go:"GO:0045202"(synapse)|go:"GO:0070180"(large ribosomal subunit rRNA binding)|go:"GO:0071320"(cellular response to cAMP)|go:"GO:0071353"(cellular response to interleukin-4)|go:"GO:0098794"(postsynapse)|go:"GO:1904401"(cellular response to Thyroid stimulating hormone)|go:"GO:1904628"(cellular response to phorbol 13-acetate 12-myristate)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR001790(Ribosomal protein L10)|interpro:IPR030670|interpro:IPR040637|interpro:IPR043141|interpro:IPR043164|mint:P19945|reactome:R-RNO-156827|reactome:R-RNO-1799339|reactome:R-RNO-6791226|reactome:R-RNO-72689|reactome:R-RNO-72706|reactome:R-RNO-975956|reactome:R-RNO-975957	-	-	-	caution:"The participant EBI-349571(P68370) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919386(Q7TP47) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920972(Q5XIP9) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-916419(P11980) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919578(Q8R491) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920554(Q5U3Z7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920647(Q5U2X8) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920585(Q7TP24) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-779677(P05426) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-915744(P02454) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|agonist:Insulin was shown to increase or decrease GLUT4 protein interactions in specific cases.|comment:"Insulin decreased GLUT4 interactions with the following proteins: Q9ER30 (Sarcosin), P09527 (Rab-7), O88960 (N-ethylmaleimide sensitive), P09456 (PKA I regulatory subunit), P27881 (Hexokinase type II), P07872 (Acyl-coenzyme A oxidase), Q6DGF1 (Isocitrate dehydrogenase), Q9EQX9 (Ubiquitin-conjugating), Q63446 (Polyubiquitin), P24268 (Cathepsin D), Q91XW0 (Heat shock protein 86), Q5FVH0 (unknown), P58405 (Striatin 3), Q62667 (Major vault protein), Q66H50 (unknown), Q09167 (splicing factor), Q9JHU5 (Arfaptin 1)."|comment:"Insulin increased GLUT4 interaction with the following proteins:Q9Z1P2 (R-actinin-1), P45592 (Cofilin), Q9QXQ0 (R-actinin-4), P26473 (ADP-ribosylation factor), P26437 (ADP-ribosylation factor),   Q7TNP1 (Basigin 2), Q6P6R2 (Dihydrolipoamide dehydrogenase),   P04797 (GAPDH), Q63081 (Protein disulfide isomerase), P29457 (47 kDa heat shock protein), Q9R1J8 (Leprecan), O88638 (Putative eps protein),   Q64375 (Synaptonemal complex)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:NDPK - Interactions involving proteins containing InterPro domain IPR001564, Nucleoside diphosphate kinase, core.	taxid:10116(rat-l6)|taxid:10116(Rattus norvegicus)	-	2006/02/15	2021/11/30	rogid:PbFY2lfrty8yw40Jq7ShR7xfuV410116	rogid:ZHQiXyp126dzMM4xe4iEDF2gd4810116	intact-crc:44F3A2176D02515F|rigid:9RVm0UBcqQF4k06RGKO89Bg16Q8	false	myc tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P19357	uniprotkb:P19804	intact:EBI-915426|uniprotkb:P97900|ensembl:ENSRNOP00000023256	intact:EBI-916775|ensembl:ENSRNOP00000003611	psi-mi:glut4_rat(display_long)|uniprotkb:Glucose transporter type 4, insulin-responsive(gene name synonym)|uniprotkb:Slc2a4(gene name)|psi-mi:Slc2a4(display_short)|uniprotkb:Glut4(gene name synonym)	psi-mi:ndkb_rat(display_long)|uniprotkb:P18(gene name synonym)|uniprotkb:Nme2(gene name)|psi-mi:Nme2(display_short)|uniprotkb:Histidine protein kinase NDKB(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Foster et al. (2006)	pubmed:16396496|mint:MINT-5218203	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-921030	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2711|refseq:NP_036883.1|refseq:XP_006246658.1|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007611"(learning or memory)|go:"GO:0007614"(short-term memory)|go:"GO:0007616"(long-term memory)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010021"(amylopectin biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031550"(positive regulation of brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044381"(glucose import in response to insulin stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046323"(glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0098694"(regulation of synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0098793"(presynapse)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002441("Glucose transporter, type 4 (GLUT4)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-189200|ensembl:ENSRNOG00000017226(gene)|ensembl:ENSRNOT00000023256(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)	rgd:619877|refseq:NP_114021.2|ensembl:ENSRNOG00000002671(gene)|ensembl:ENSRNOT00000003611(transcript)|go:"GO:0001726"(ruffle)|go:"GO:0002762"(negative regulation of myeloid leukocyte differentiation)|go:"GO:0003677"(DNA binding)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0004550"(nucleoside diphosphate kinase activity)|go:"GO:0004673"(protein histidine kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005504"(fatty acid binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006165"(nucleoside diphosphate phosphorylation)|go:"GO:0006183"(GTP biosynthetic process)|go:"GO:0006228"(UTP biosynthetic process)|go:"GO:0006241"(CTP biosynthetic process)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0009142"(nucleoside triphosphate biosynthetic process)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0019003"(GDP binding)|go:"GO:0019215"(intermediate filament binding)|go:"GO:0019899"(enzyme binding)|go:"GO:0030027"(lamellipodium)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0042802"(identical protein binding)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0045618"(positive regulation of keratinocyte differentiation)|go:"GO:0045682"(regulation of epidermis development)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046872"(metal ion binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050679"(positive regulation of epithelial cell proliferation)|go:"GO:0051880"(G-quadruplex DNA binding)|go:"GO:0060416"(response to growth hormone)|go:"GO:0071333"(cellular response to glucose stimulus)|go:"GO:0071398"(cellular response to fatty acid)|go:"GO:0071944"(cell periphery)|go:"GO:1901363"(heterocyclic compound binding)|interpro:IPR001564(Nucleoside diphosphate kinase, core)|interpro:IPR023005|interpro:IPR034907|interpro:IPR036850|reactome:R-RNO-499943|reactome:R-RNO-6798695	-	-	-	caution:"The participant EBI-349571(P68370) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919386(Q7TP47) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920972(Q5XIP9) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-916419(P11980) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919578(Q8R491) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920554(Q5U3Z7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920647(Q5U2X8) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920585(Q7TP24) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-779677(P05426) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-915744(P02454) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|agonist:Insulin was shown to increase or decrease GLUT4 protein interactions in specific cases.|comment:"Insulin decreased GLUT4 interactions with the following proteins: Q9ER30 (Sarcosin), P09527 (Rab-7), O88960 (N-ethylmaleimide sensitive), P09456 (PKA I regulatory subunit), P27881 (Hexokinase type II), P07872 (Acyl-coenzyme A oxidase), Q6DGF1 (Isocitrate dehydrogenase), Q9EQX9 (Ubiquitin-conjugating), Q63446 (Polyubiquitin), P24268 (Cathepsin D), Q91XW0 (Heat shock protein 86), Q5FVH0 (unknown), P58405 (Striatin 3), Q62667 (Major vault protein), Q66H50 (unknown), Q09167 (splicing factor), Q9JHU5 (Arfaptin 1)."|comment:"Insulin increased GLUT4 interaction with the following proteins:Q9Z1P2 (R-actinin-1), P45592 (Cofilin), Q9QXQ0 (R-actinin-4), P26473 (ADP-ribosylation factor), P26437 (ADP-ribosylation factor),   Q7TNP1 (Basigin 2), Q6P6R2 (Dihydrolipoamide dehydrogenase),   P04797 (GAPDH), Q63081 (Protein disulfide isomerase), P29457 (47 kDa heat shock protein), Q9R1J8 (Leprecan), O88638 (Putative eps protein),   Q64375 (Synaptonemal complex)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:NDPK - Interactions involving proteins containing InterPro domain IPR001564, Nucleoside diphosphate kinase, core.	taxid:10116(rat-l6)|taxid:10116(Rattus norvegicus)	-	2006/02/15	2021/11/30	rogid:PbFY2lfrty8yw40Jq7ShR7xfuV410116	rogid:GqinlV9dt7k6bUTLeZP5IJJQqUE10116	intact-crc:44F3A2176D02515F|rigid:9RVm0UBcqQF4k06RGKO89Bg16Q8	false	myc tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P19357	uniprotkb:P97536	intact:EBI-915426|uniprotkb:P97900|ensembl:ENSRNOP00000023256	intact:EBI-918083|ensembl:ENSRNOP00000010720	psi-mi:glut4_rat(display_long)|uniprotkb:Glucose transporter type 4, insulin-responsive(gene name synonym)|uniprotkb:Slc2a4(gene name)|psi-mi:Slc2a4(display_short)|uniprotkb:Glut4(gene name synonym)	psi-mi:cand1_rat(display_long)|uniprotkb:Cullin-associated and neddylation-dissociated protein 1(gene name synonym)|uniprotkb:p120 CAND1(gene name synonym)|uniprotkb:TBP-interacting protein of 120 kDa A(gene name synonym)|uniprotkb:Cand1(gene name)|psi-mi:Cand1(display_short)|uniprotkb:Tip120(gene name synonym)|uniprotkb:Tip120a(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Foster et al. (2006)	pubmed:16396496|mint:MINT-5218203	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-921030	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2711|refseq:NP_036883.1|refseq:XP_006246658.1|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007611"(learning or memory)|go:"GO:0007614"(short-term memory)|go:"GO:0007616"(long-term memory)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010021"(amylopectin biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031550"(positive regulation of brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044381"(glucose import in response to insulin stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046323"(glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0098694"(regulation of synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0098793"(presynapse)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002441("Glucose transporter, type 4 (GLUT4)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-189200|ensembl:ENSRNOG00000017226(gene)|ensembl:ENSRNOT00000023256(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)	rgd:620479|refseq:NP_446456.1|ensembl:ENSRNOG00000007834(gene)|ensembl:ENSRNOT00000010720(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0010265"(SCF complex assembly)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0017025"(TBP-class protein binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0031461"(cullin-RING ubiquitin ligase complex)|go:"GO:0043086"(negative regulation of catalytic activity)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045899"(positive regulation of RNA polymerase II transcription preinitiation complex assembly)|interpro:IPR013932("TATA-binding protein interacting (TIP20)")|interpro:IPR016024(Armadillo-type fold)|interpro:IPR039852|mint:P97536|reactome:R-RNO-6798695|reactome:R-RNO-8951664|reactome:R-RNO-917937	-	-	-	caution:"The participant EBI-349571(P68370) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919386(Q7TP47) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920972(Q5XIP9) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-916419(P11980) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919578(Q8R491) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920554(Q5U3Z7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920647(Q5U2X8) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920585(Q7TP24) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-779677(P05426) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-915744(P02454) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|agonist:Insulin was shown to increase or decrease GLUT4 protein interactions in specific cases.|comment:"Insulin decreased GLUT4 interactions with the following proteins: Q9ER30 (Sarcosin), P09527 (Rab-7), O88960 (N-ethylmaleimide sensitive), P09456 (PKA I regulatory subunit), P27881 (Hexokinase type II), P07872 (Acyl-coenzyme A oxidase), Q6DGF1 (Isocitrate dehydrogenase), Q9EQX9 (Ubiquitin-conjugating), Q63446 (Polyubiquitin), P24268 (Cathepsin D), Q91XW0 (Heat shock protein 86), Q5FVH0 (unknown), P58405 (Striatin 3), Q62667 (Major vault protein), Q66H50 (unknown), Q09167 (splicing factor), Q9JHU5 (Arfaptin 1)."|comment:"Insulin increased GLUT4 interaction with the following proteins:Q9Z1P2 (R-actinin-1), P45592 (Cofilin), Q9QXQ0 (R-actinin-4), P26473 (ADP-ribosylation factor), P26437 (ADP-ribosylation factor),   Q7TNP1 (Basigin 2), Q6P6R2 (Dihydrolipoamide dehydrogenase),   P04797 (GAPDH), Q63081 (Protein disulfide isomerase), P29457 (47 kDa heat shock protein), Q9R1J8 (Leprecan), O88638 (Putative eps protein),   Q64375 (Synaptonemal complex)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:NDPK - Interactions involving proteins containing InterPro domain IPR001564, Nucleoside diphosphate kinase, core.	taxid:10116(rat-l6)|taxid:10116(Rattus norvegicus)	-	2006/02/15	2021/11/30	rogid:PbFY2lfrty8yw40Jq7ShR7xfuV410116	rogid:AYiE0tEiNw1ias86oxC6CxJm5uo10116	intact-crc:44F3A2176D02515F|rigid:9RVm0UBcqQF4k06RGKO89Bg16Q8	false	myc tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P19357	uniprotkb:P42667	intact:EBI-915426|uniprotkb:P97900|ensembl:ENSRNOP00000023256	intact:EBI-917479	psi-mi:glut4_rat(display_long)|uniprotkb:Glucose transporter type 4, insulin-responsive(gene name synonym)|uniprotkb:Slc2a4(gene name)|psi-mi:Slc2a4(display_short)|uniprotkb:Glut4(gene name synonym)	psi-mi:sc11a_rat(display_long)|uniprotkb:SEC11 homolog A(gene name synonym)|uniprotkb:SEC11-like protein 1(gene name synonym)|uniprotkb:Microsomal signal peptidase 18 kDa subunit(gene name synonym)|uniprotkb:SPC18(gene name synonym)|uniprotkb:Endopeptidase SP18(gene name synonym)|uniprotkb:Sec11a(gene name)|psi-mi:Sec11a(display_short)|uniprotkb:Spc18(gene name synonym)|uniprotkb:Sec11l1(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Foster et al. (2006)	pubmed:16396496|mint:MINT-5218203	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-921030	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2711|refseq:NP_036883.1|refseq:XP_006246658.1|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007611"(learning or memory)|go:"GO:0007614"(short-term memory)|go:"GO:0007616"(long-term memory)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010021"(amylopectin biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031550"(positive regulation of brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044381"(glucose import in response to insulin stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046323"(glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0098694"(regulation of synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0098793"(presynapse)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002441("Glucose transporter, type 4 (GLUT4)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-189200|ensembl:ENSRNOG00000017226(gene)|ensembl:ENSRNOT00000023256(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)	interpro:IPR019758|interpro:IPR019756|interpro:IPR015927(Peptidase S24, S26A, S26B and S26C)|interpro:IPR001733(Peptidase S26B, eukaryotic signal peptidase)|rgd:69360|interpro:IPR037712|interpro:IPR036286|reactome:R-RNO-422085|interpro:IPR019533|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005787"(signal peptidase complex)|go:"GO:0006465"(signal peptide processing)|go:"GO:0008233"(peptidase activity)|go:"GO:0016021"(integral component of membrane)	-	-	-	caution:"The participant EBI-349571(P68370) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919386(Q7TP47) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920972(Q5XIP9) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-916419(P11980) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919578(Q8R491) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920554(Q5U3Z7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920647(Q5U2X8) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920585(Q7TP24) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-779677(P05426) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-915744(P02454) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|agonist:Insulin was shown to increase or decrease GLUT4 protein interactions in specific cases.|comment:"Insulin decreased GLUT4 interactions with the following proteins: Q9ER30 (Sarcosin), P09527 (Rab-7), O88960 (N-ethylmaleimide sensitive), P09456 (PKA I regulatory subunit), P27881 (Hexokinase type II), P07872 (Acyl-coenzyme A oxidase), Q6DGF1 (Isocitrate dehydrogenase), Q9EQX9 (Ubiquitin-conjugating), Q63446 (Polyubiquitin), P24268 (Cathepsin D), Q91XW0 (Heat shock protein 86), Q5FVH0 (unknown), P58405 (Striatin 3), Q62667 (Major vault protein), Q66H50 (unknown), Q09167 (splicing factor), Q9JHU5 (Arfaptin 1)."|comment:"Insulin increased GLUT4 interaction with the following proteins:Q9Z1P2 (R-actinin-1), P45592 (Cofilin), Q9QXQ0 (R-actinin-4), P26473 (ADP-ribosylation factor), P26437 (ADP-ribosylation factor),   Q7TNP1 (Basigin 2), Q6P6R2 (Dihydrolipoamide dehydrogenase),   P04797 (GAPDH), Q63081 (Protein disulfide isomerase), P29457 (47 kDa heat shock protein), Q9R1J8 (Leprecan), O88638 (Putative eps protein),   Q64375 (Synaptonemal complex)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:NDPK - Interactions involving proteins containing InterPro domain IPR001564, Nucleoside diphosphate kinase, core.	taxid:10116(rat-l6)|taxid:10116(Rattus norvegicus)	-	2006/02/15	2021/11/30	rogid:PbFY2lfrty8yw40Jq7ShR7xfuV410116	rogid:gHL5/cpTmwSaogKXKPd4QSQzHN810116	intact-crc:44F3A2176D02515F|rigid:9RVm0UBcqQF4k06RGKO89Bg16Q8	false	myc tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P19357	uniprotkb:P97519	intact:EBI-915426|uniprotkb:P97900|ensembl:ENSRNOP00000023256	intact:EBI-918077|ensembl:ENSRNOP00000012853	psi-mi:glut4_rat(display_long)|uniprotkb:Glucose transporter type 4, insulin-responsive(gene name synonym)|uniprotkb:Slc2a4(gene name)|psi-mi:Slc2a4(display_short)|uniprotkb:Glut4(gene name synonym)	psi-mi:hmgcl_rat(display_long)|uniprotkb:3-hydroxy-3-methylglutarate-CoA lyase(gene name synonym)|uniprotkb:Hmgcl(gene name)|psi-mi:Hmgcl(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Foster et al. (2006)	pubmed:16396496|mint:MINT-5218203	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-921030	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2711|refseq:NP_036883.1|refseq:XP_006246658.1|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007611"(learning or memory)|go:"GO:0007614"(short-term memory)|go:"GO:0007616"(long-term memory)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010021"(amylopectin biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031550"(positive regulation of brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044381"(glucose import in response to insulin stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046323"(glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0098694"(regulation of synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0098793"(presynapse)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002441("Glucose transporter, type 4 (GLUT4)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-189200|ensembl:ENSRNOG00000017226(gene)|ensembl:ENSRNOT00000023256(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)	rgd:620554|refseq:NP_077362.1|ensembl:ENSRNOG00000009422(gene)|ensembl:ENSRNOT00000012853(transcript)|go:"GO:0000062"(fatty-acyl-CoA binding)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0001889"(liver development)|go:"GO:0004419"(hydroxymethylglutaryl-CoA lyase activity)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0005777"(peroxisome)|go:"GO:0006552"(leucine catabolic process)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0006637"(acyl-CoA metabolic process)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0007584"(response to nutrient)|go:"GO:0030145"(manganese ion binding)|go:"GO:0031406"(carboxylic acid binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042594"(response to starvation)|go:"GO:0046872"(metal ion binding)|go:"GO:0046951"(ketone body biosynthetic process)|go:"GO:0070542"(response to fatty acid)|interpro:IPR000138(Hydroxymethylglutaryl-CoA lyase, active site)|interpro:IPR000891(Pyruvate carboxyltransferase)|interpro:IPR013785(Aldolase-type TIM barrel)|interpro:IPR043594|reactome:R-RNO-77111|reactome:R-RNO-9033241	-	-	-	caution:"The participant EBI-349571(P68370) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919386(Q7TP47) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920972(Q5XIP9) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-916419(P11980) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919578(Q8R491) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920554(Q5U3Z7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920647(Q5U2X8) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920585(Q7TP24) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-779677(P05426) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-915744(P02454) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|agonist:Insulin was shown to increase or decrease GLUT4 protein interactions in specific cases.|comment:"Insulin decreased GLUT4 interactions with the following proteins: Q9ER30 (Sarcosin), P09527 (Rab-7), O88960 (N-ethylmaleimide sensitive), P09456 (PKA I regulatory subunit), P27881 (Hexokinase type II), P07872 (Acyl-coenzyme A oxidase), Q6DGF1 (Isocitrate dehydrogenase), Q9EQX9 (Ubiquitin-conjugating), Q63446 (Polyubiquitin), P24268 (Cathepsin D), Q91XW0 (Heat shock protein 86), Q5FVH0 (unknown), P58405 (Striatin 3), Q62667 (Major vault protein), Q66H50 (unknown), Q09167 (splicing factor), Q9JHU5 (Arfaptin 1)."|comment:"Insulin increased GLUT4 interaction with the following proteins:Q9Z1P2 (R-actinin-1), P45592 (Cofilin), Q9QXQ0 (R-actinin-4), P26473 (ADP-ribosylation factor), P26437 (ADP-ribosylation factor),   Q7TNP1 (Basigin 2), Q6P6R2 (Dihydrolipoamide dehydrogenase),   P04797 (GAPDH), Q63081 (Protein disulfide isomerase), P29457 (47 kDa heat shock protein), Q9R1J8 (Leprecan), O88638 (Putative eps protein),   Q64375 (Synaptonemal complex)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:NDPK - Interactions involving proteins containing InterPro domain IPR001564, Nucleoside diphosphate kinase, core.	taxid:10116(rat-l6)|taxid:10116(Rattus norvegicus)	-	2006/02/15	2021/11/30	rogid:PbFY2lfrty8yw40Jq7ShR7xfuV410116	rogid:Xq6PAZYa0eRR1urs4V54oUN6SIo10116	intact-crc:44F3A2176D02515F|rigid:9RVm0UBcqQF4k06RGKO89Bg16Q8	false	myc tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P19357	uniprotkb:P83888	intact:EBI-915426|uniprotkb:P97900|ensembl:ENSRNOP00000023256	intact:EBI-302581|ensembl:ENSRNOP00000027370|uniprotkb:Q9Z310	psi-mi:glut4_rat(display_long)|uniprotkb:Glucose transporter type 4, insulin-responsive(gene name synonym)|uniprotkb:Slc2a4(gene name)|psi-mi:Slc2a4(display_short)|uniprotkb:Glut4(gene name synonym)	psi-mi:tbg1_rat(display_long)|uniprotkb:Tubg1(gene name)|psi-mi:Tubg1(display_short)|uniprotkb:Tubg(gene name synonym)|uniprotkb:Gamma-1-tubulin(gene name synonym)|uniprotkb:Gamma-tubulin complex component 1(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Foster et al. (2006)	pubmed:16396496|mint:MINT-5218203	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-921030	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2711|refseq:NP_036883.1|refseq:XP_006246658.1|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007611"(learning or memory)|go:"GO:0007614"(short-term memory)|go:"GO:0007616"(long-term memory)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010021"(amylopectin biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031550"(positive regulation of brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044381"(glucose import in response to insulin stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046323"(glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0098694"(regulation of synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0098793"(presynapse)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002441("Glucose transporter, type 4 (GLUT4)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-189200|ensembl:ENSRNOG00000017226(gene)|ensembl:ENSRNOT00000023256(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)	ensembl:ENSRNOG00000020213(gene)|ensembl:ENSRNOT00000027370(transcript)|go:"GO:0000070"(mitotic sister chromatid segregation)|go:"GO:0000212"(meiotic spindle organization)|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0000242"(pericentriolar material)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0000794"(condensed nuclear chromosome)|go:"GO:0000930"(gamma-tubulin complex)|go:"GO:0005200"(structural constituent of cytoskeleton)|go:"GO:0005525"(GTP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005814"(centriole)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0005819"(spindle)|go:"GO:0005827"(polar microtubule)|rgd:628606|refseq:NP_665721.1|interpro:IPR008280(Tubulin/FtsZ, C-terminal)|interpro:IPR017975|interpro:IPR018316|interpro:IPR023123|interpro:IPR036525|interpro:IPR037103|reactome:R-RNO-2565942|reactome:R-RNO-380259|reactome:R-RNO-380270|reactome:R-RNO-380284|reactome:R-RNO-380320|reactome:R-RNO-5620912|reactome:R-RNO-8854518|go:"GO:0005874"(microtubule)|go:"GO:0005876"(spindle microtubule)|go:"GO:0005881"(cytoplasmic microtubule)|go:"GO:0005929"(cilium)|go:"GO:0007020"(microtubule nucleation)|go:"GO:0007052"(mitotic spindle organization)|go:"GO:0031122"(cytoplasmic microtubule organization)|go:"GO:0031252"(cell leading edge)|go:"GO:0036064"(ciliary basal body)|go:"GO:0042802"(identical protein binding)|go:"GO:0045177"(apical part of cell)|go:"GO:0055037"(recycling endosome)|go:"GO:0097730"(non-motile cilium)|go:"GO:1990498"(mitotic spindle microtubule)|interpro:IPR000217(Tubulin)|interpro:IPR002454(Gamma tubulin)|interpro:IPR003008(Tubulin/FtsZ, GTPase)	-	-	-	caution:"The participant EBI-349571(P68370) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919386(Q7TP47) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920972(Q5XIP9) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-916419(P11980) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919578(Q8R491) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920554(Q5U3Z7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920647(Q5U2X8) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920585(Q7TP24) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-779677(P05426) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-915744(P02454) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|agonist:Insulin was shown to increase or decrease GLUT4 protein interactions in specific cases.|comment:"Insulin decreased GLUT4 interactions with the following proteins: Q9ER30 (Sarcosin), P09527 (Rab-7), O88960 (N-ethylmaleimide sensitive), P09456 (PKA I regulatory subunit), P27881 (Hexokinase type II), P07872 (Acyl-coenzyme A oxidase), Q6DGF1 (Isocitrate dehydrogenase), Q9EQX9 (Ubiquitin-conjugating), Q63446 (Polyubiquitin), P24268 (Cathepsin D), Q91XW0 (Heat shock protein 86), Q5FVH0 (unknown), P58405 (Striatin 3), Q62667 (Major vault protein), Q66H50 (unknown), Q09167 (splicing factor), Q9JHU5 (Arfaptin 1)."|comment:"Insulin increased GLUT4 interaction with the following proteins:Q9Z1P2 (R-actinin-1), P45592 (Cofilin), Q9QXQ0 (R-actinin-4), P26473 (ADP-ribosylation factor), P26437 (ADP-ribosylation factor),   Q7TNP1 (Basigin 2), Q6P6R2 (Dihydrolipoamide dehydrogenase),   P04797 (GAPDH), Q63081 (Protein disulfide isomerase), P29457 (47 kDa heat shock protein), Q9R1J8 (Leprecan), O88638 (Putative eps protein),   Q64375 (Synaptonemal complex)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:NDPK - Interactions involving proteins containing InterPro domain IPR001564, Nucleoside diphosphate kinase, core.	taxid:10116(rat-l6)|taxid:10116(Rattus norvegicus)	-	2006/02/15	2021/11/30	rogid:PbFY2lfrty8yw40Jq7ShR7xfuV410116	rogid:vuOzSmoj6s4iR1pV9zNfwxYjue810116	intact-crc:44F3A2176D02515F|rigid:9RVm0UBcqQF4k06RGKO89Bg16Q8	false	myc tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P19357	uniprotkb:P83732	intact:EBI-915426|uniprotkb:P97900|ensembl:ENSRNOP00000023256	intact:EBI-918070|uniprotkb:P38663	psi-mi:glut4_rat(display_long)|uniprotkb:Glucose transporter type 4, insulin-responsive(gene name synonym)|uniprotkb:Slc2a4(gene name)|psi-mi:Slc2a4(display_short)|uniprotkb:Glut4(gene name synonym)	psi-mi:rl24_rat(display_long)|uniprotkb:L30(gene name synonym)|uniprotkb:Rpl24(gene name)|psi-mi:Rpl24(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Foster et al. (2006)	pubmed:16396496|mint:MINT-5218203	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-921030	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2711|refseq:NP_036883.1|refseq:XP_006246658.1|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007611"(learning or memory)|go:"GO:0007614"(short-term memory)|go:"GO:0007616"(long-term memory)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010021"(amylopectin biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031550"(positive regulation of brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044381"(glucose import in response to insulin stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046323"(glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0098694"(regulation of synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0098793"(presynapse)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002441("Glucose transporter, type 4 (GLUT4)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-189200|ensembl:ENSRNOG00000017226(gene)|ensembl:ENSRNOT00000023256(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)	rgd:621191|refseq:NP_071960.1|interpro:IPR023442|interpro:IPR000988(Ribosomal protein L24e)|interpro:IPR011017(TRASH)|interpro:IPR038630|reactome:R-RNO-156827|reactome:R-RNO-1799339|reactome:R-RNO-6791226|reactome:R-RNO-72689|reactome:R-RNO-72706|reactome:R-RNO-975956|reactome:R-RNO-975957|go:"GO:0000027"(ribosomal large subunit assembly)|go:"GO:0002181"(cytoplasmic translation)|go:"GO:0003723"(RNA binding)|go:"GO:0003735"(structural constituent of ribosome)|go:"GO:0005737"(cytoplasm)|go:"GO:0006412"(translation)|go:"GO:0010458"(exit from mitosis)|go:"GO:0021554"(optic nerve development)|go:"GO:0022625"(cytosolic large ribosomal subunit)|go:"GO:0022626"(cytosolic ribosome)|go:"GO:0031290"(retinal ganglion cell axon guidance)|go:"GO:0042788"(polysomal ribosome)|go:"GO:0045202"(synapse)|go:"GO:0060041"(retina development in camera-type eye)|go:"GO:1902626"(assembly of large subunit precursor of preribosome)	-	-	-	caution:"The participant EBI-349571(P68370) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919386(Q7TP47) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920972(Q5XIP9) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-916419(P11980) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919578(Q8R491) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920554(Q5U3Z7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920647(Q5U2X8) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920585(Q7TP24) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-779677(P05426) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-915744(P02454) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|agonist:Insulin was shown to increase or decrease GLUT4 protein interactions in specific cases.|comment:"Insulin decreased GLUT4 interactions with the following proteins: Q9ER30 (Sarcosin), P09527 (Rab-7), O88960 (N-ethylmaleimide sensitive), P09456 (PKA I regulatory subunit), P27881 (Hexokinase type II), P07872 (Acyl-coenzyme A oxidase), Q6DGF1 (Isocitrate dehydrogenase), Q9EQX9 (Ubiquitin-conjugating), Q63446 (Polyubiquitin), P24268 (Cathepsin D), Q91XW0 (Heat shock protein 86), Q5FVH0 (unknown), P58405 (Striatin 3), Q62667 (Major vault protein), Q66H50 (unknown), Q09167 (splicing factor), Q9JHU5 (Arfaptin 1)."|comment:"Insulin increased GLUT4 interaction with the following proteins:Q9Z1P2 (R-actinin-1), P45592 (Cofilin), Q9QXQ0 (R-actinin-4), P26473 (ADP-ribosylation factor), P26437 (ADP-ribosylation factor),   Q7TNP1 (Basigin 2), Q6P6R2 (Dihydrolipoamide dehydrogenase),   P04797 (GAPDH), Q63081 (Protein disulfide isomerase), P29457 (47 kDa heat shock protein), Q9R1J8 (Leprecan), O88638 (Putative eps protein),   Q64375 (Synaptonemal complex)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:NDPK - Interactions involving proteins containing InterPro domain IPR001564, Nucleoside diphosphate kinase, core.	taxid:10116(rat-l6)|taxid:10116(Rattus norvegicus)	-	2006/02/15	2021/11/30	rogid:PbFY2lfrty8yw40Jq7ShR7xfuV410116	rogid:+Ah+YGgcjqOsk5ZS1HZUMQA/Of810116	intact-crc:44F3A2176D02515F|rigid:9RVm0UBcqQF4k06RGKO89Bg16Q8	false	myc tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P19357	uniprotkb:P81155	intact:EBI-915426|uniprotkb:P97900|ensembl:ENSRNOP00000023256	intact:EBI-918064|uniprotkb:Q9JI32|ensembl:ENSRNOP00000018462|ensembl:ENSRNOP00000074839	psi-mi:glut4_rat(display_long)|uniprotkb:Glucose transporter type 4, insulin-responsive(gene name synonym)|uniprotkb:Slc2a4(gene name)|psi-mi:Slc2a4(display_short)|uniprotkb:Glut4(gene name synonym)	psi-mi:vdac2_rat(display_long)|uniprotkb:Outer mitochondrial membrane protein porin 2(gene name synonym)|uniprotkb:B36-VDAC(gene name synonym)|uniprotkb:Vdac2(gene name)|psi-mi:Vdac2(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Foster et al. (2006)	pubmed:16396496|mint:MINT-5218203	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-921030	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2711|refseq:NP_036883.1|refseq:XP_006246658.1|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007611"(learning or memory)|go:"GO:0007614"(short-term memory)|go:"GO:0007616"(long-term memory)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010021"(amylopectin biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031550"(positive regulation of brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044381"(glucose import in response to insulin stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046323"(glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0098694"(regulation of synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0098793"(presynapse)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002441("Glucose transporter, type 4 (GLUT4)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-189200|ensembl:ENSRNOG00000017226(gene)|ensembl:ENSRNOT00000023256(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)	rgd:621576|refseq:NP_112644.1|refseq:XP_006251723.1|ensembl:ENSRNOG00000013505(gene)|ensembl:ENSRNOT00000018462(transcript)|ensembl:ENSRNOT00000086864(transcript)|go:"GO:0000166"(nucleotide binding)|go:"GO:0001669"(acrosomal vesicle)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0006820"(anion transport)|go:"GO:0007339"(binding of sperm to zona pellucida)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008308"(voltage-gated anion channel activity)|go:"GO:0015288"(porin activity)|go:"GO:0015485"(cholesterol binding)|go:"GO:0016020"(membrane)|go:"GO:0031210"(phosphatidylcholine binding)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0032272"(negative regulation of protein polymerization)|go:"GO:0042645"(mitochondrial nucleoid)|go:"GO:0046930"(pore complex)|go:"GO:0097001"(ceramide binding)|go:"GO:0097345"(mitochondrial outer membrane permeabilization)|go:"GO:2001243"(negative regulation of intrinsic apoptotic signaling pathway)|interpro:IPR001925(Porin, eukaryotic type)|interpro:IPR023614|interpro:IPR027246|interpro:IPR030277|mint:P81155|reactome:R-RNO-5689880	-	-	-	caution:"The participant EBI-349571(P68370) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919386(Q7TP47) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920972(Q5XIP9) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-916419(P11980) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919578(Q8R491) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920554(Q5U3Z7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920647(Q5U2X8) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920585(Q7TP24) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-779677(P05426) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-915744(P02454) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|agonist:Insulin was shown to increase or decrease GLUT4 protein interactions in specific cases.|comment:"Insulin decreased GLUT4 interactions with the following proteins: Q9ER30 (Sarcosin), P09527 (Rab-7), O88960 (N-ethylmaleimide sensitive), P09456 (PKA I regulatory subunit), P27881 (Hexokinase type II), P07872 (Acyl-coenzyme A oxidase), Q6DGF1 (Isocitrate dehydrogenase), Q9EQX9 (Ubiquitin-conjugating), Q63446 (Polyubiquitin), P24268 (Cathepsin D), Q91XW0 (Heat shock protein 86), Q5FVH0 (unknown), P58405 (Striatin 3), Q62667 (Major vault protein), Q66H50 (unknown), Q09167 (splicing factor), Q9JHU5 (Arfaptin 1)."|comment:"Insulin increased GLUT4 interaction with the following proteins:Q9Z1P2 (R-actinin-1), P45592 (Cofilin), Q9QXQ0 (R-actinin-4), P26473 (ADP-ribosylation factor), P26437 (ADP-ribosylation factor),   Q7TNP1 (Basigin 2), Q6P6R2 (Dihydrolipoamide dehydrogenase),   P04797 (GAPDH), Q63081 (Protein disulfide isomerase), P29457 (47 kDa heat shock protein), Q9R1J8 (Leprecan), O88638 (Putative eps protein),   Q64375 (Synaptonemal complex)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:NDPK - Interactions involving proteins containing InterPro domain IPR001564, Nucleoside diphosphate kinase, core.	taxid:10116(rat-l6)|taxid:10116(Rattus norvegicus)	-	2006/02/15	2021/11/30	rogid:PbFY2lfrty8yw40Jq7ShR7xfuV410116	rogid:4hSm4QQy24guxjuUCy/7W97UqL810116	intact-crc:44F3A2176D02515F|rigid:9RVm0UBcqQF4k06RGKO89Bg16Q8	false	myc tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P19357	uniprotkb:P80385	intact:EBI-915426|uniprotkb:P97900|ensembl:ENSRNOP00000023256	intact:EBI-918056|uniprotkb:Q4QQW6|ensembl:ENSRNOP00000070458	psi-mi:glut4_rat(display_long)|uniprotkb:Glucose transporter type 4, insulin-responsive(gene name synonym)|uniprotkb:Slc2a4(gene name)|psi-mi:Slc2a4(display_short)|uniprotkb:Glut4(gene name synonym)	psi-mi:aakg1_rat(display_long)|uniprotkb:Prkag1(gene name)|psi-mi:Prkag1(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Foster et al. (2006)	pubmed:16396496|mint:MINT-5218203	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-921030	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2711|refseq:NP_036883.1|refseq:XP_006246658.1|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007611"(learning or memory)|go:"GO:0007614"(short-term memory)|go:"GO:0007616"(long-term memory)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010021"(amylopectin biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031550"(positive regulation of brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044381"(glucose import in response to insulin stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046323"(glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0098694"(regulation of synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0098793"(presynapse)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002441("Glucose transporter, type 4 (GLUT4)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-189200|ensembl:ENSRNOG00000017226(gene)|ensembl:ENSRNOT00000023256(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)	rgd:3388|refseq:NP_037142.1|dip:DIP-37278N|ensembl:ENSRNOG00000061499(gene)|ensembl:ENSRNOT00000083354(transcript)|go:"GO:0004672"(protein kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006633"(fatty acid biosynthetic process)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016208"(AMP binding)|go:"GO:0019887"(protein kinase regulator activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0031588"(nucleotide-activated protein kinase complex)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042149"(cellular response to glucose starvation)|go:"GO:0043531"(ADP binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0050790"(regulation of catalytic activity)|go:"GO:0051170"(import into nucleus)|go:"GO:0071900"(regulation of protein serine/threonine kinase activity)|interpro:IPR000644(Cystathionine beta-synthase, core)|interpro:IPR039166|rcsb pdb:2V8Q|rcsb pdb:2V92|rcsb pdb:2V9J|rcsb pdb:2Y8L|rcsb pdb:2Y8Q|rcsb pdb:2YA3|rcsb pdb:4CFH|rcsb pdb:4EAG|rcsb pdb:4EAI|rcsb pdb:4EAJ|rcsb pdb:4EAK|rcsb pdb:4EAL|rcsb pdb:4QFG|rcsb pdb:4QFR|rcsb pdb:4QFS|rcsb pdb:5KQ5|rcsb pdb:5T5T|rcsb pdb:5UFU|rcsb pdb:6E4T|rcsb pdb:6E4U|rcsb pdb:6E4W|reactome:R-RNO-1632852|reactome:R-RNO-380972|reactome:R-RNO-5628897|reactome:R-RNO-6804756	-	-	-	caution:"The participant EBI-349571(P68370) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919386(Q7TP47) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920972(Q5XIP9) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-916419(P11980) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919578(Q8R491) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920554(Q5U3Z7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920647(Q5U2X8) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920585(Q7TP24) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-779677(P05426) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-915744(P02454) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|agonist:Insulin was shown to increase or decrease GLUT4 protein interactions in specific cases.|comment:"Insulin decreased GLUT4 interactions with the following proteins: Q9ER30 (Sarcosin), P09527 (Rab-7), O88960 (N-ethylmaleimide sensitive), P09456 (PKA I regulatory subunit), P27881 (Hexokinase type II), P07872 (Acyl-coenzyme A oxidase), Q6DGF1 (Isocitrate dehydrogenase), Q9EQX9 (Ubiquitin-conjugating), Q63446 (Polyubiquitin), P24268 (Cathepsin D), Q91XW0 (Heat shock protein 86), Q5FVH0 (unknown), P58405 (Striatin 3), Q62667 (Major vault protein), Q66H50 (unknown), Q09167 (splicing factor), Q9JHU5 (Arfaptin 1)."|comment:"Insulin increased GLUT4 interaction with the following proteins:Q9Z1P2 (R-actinin-1), P45592 (Cofilin), Q9QXQ0 (R-actinin-4), P26473 (ADP-ribosylation factor), P26437 (ADP-ribosylation factor),   Q7TNP1 (Basigin 2), Q6P6R2 (Dihydrolipoamide dehydrogenase),   P04797 (GAPDH), Q63081 (Protein disulfide isomerase), P29457 (47 kDa heat shock protein), Q9R1J8 (Leprecan), O88638 (Putative eps protein),   Q64375 (Synaptonemal complex)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:NDPK - Interactions involving proteins containing InterPro domain IPR001564, Nucleoside diphosphate kinase, core.	taxid:10116(rat-l6)|taxid:10116(Rattus norvegicus)	-	2006/02/15	2021/11/30	rogid:PbFY2lfrty8yw40Jq7ShR7xfuV410116	rogid:uryb9rfseg81E/x+FC3Cecf2FnI10116	intact-crc:44F3A2176D02515F|rigid:9RVm0UBcqQF4k06RGKO89Bg16Q8	false	myc tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P19357	uniprotkb:P70645	intact:EBI-915426|uniprotkb:P97900|ensembl:ENSRNOP00000023256	intact:EBI-918050	psi-mi:glut4_rat(display_long)|uniprotkb:Glucose transporter type 4, insulin-responsive(gene name synonym)|uniprotkb:Slc2a4(gene name)|psi-mi:Slc2a4(display_short)|uniprotkb:Glut4(gene name synonym)	psi-mi:blmh_rat(display_long)|uniprotkb:Blmh(gene name)|psi-mi:Blmh(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Foster et al. (2006)	pubmed:16396496|mint:MINT-5218203	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-921030	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2711|refseq:NP_036883.1|refseq:XP_006246658.1|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007611"(learning or memory)|go:"GO:0007614"(short-term memory)|go:"GO:0007616"(long-term memory)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010021"(amylopectin biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031550"(positive regulation of brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044381"(glucose import in response to insulin stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046323"(glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0098694"(regulation of synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0098793"(presynapse)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002441("Glucose transporter, type 4 (GLUT4)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-189200|ensembl:ENSRNOG00000017226(gene)|ensembl:ENSRNOT00000023256(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)	rgd:1304668|interpro:IPR000169(Peptidase, cysteine peptidase active site)|interpro:IPR004134(Peptidase C1B, bleomycin hydrolase)|interpro:IPR038765|reactome:R-RNO-983168|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0008233"(peptidase activity)|go:"GO:0008234"(cysteine-type peptidase activity)|go:"GO:0009636"(response to toxic substance)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0043418"(homocysteine catabolic process)	-	-	-	caution:"The participant EBI-349571(P68370) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919386(Q7TP47) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920972(Q5XIP9) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-916419(P11980) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919578(Q8R491) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920554(Q5U3Z7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920647(Q5U2X8) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920585(Q7TP24) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-779677(P05426) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-915744(P02454) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|agonist:Insulin was shown to increase or decrease GLUT4 protein interactions in specific cases.|comment:"Insulin decreased GLUT4 interactions with the following proteins: Q9ER30 (Sarcosin), P09527 (Rab-7), O88960 (N-ethylmaleimide sensitive), P09456 (PKA I regulatory subunit), P27881 (Hexokinase type II), P07872 (Acyl-coenzyme A oxidase), Q6DGF1 (Isocitrate dehydrogenase), Q9EQX9 (Ubiquitin-conjugating), Q63446 (Polyubiquitin), P24268 (Cathepsin D), Q91XW0 (Heat shock protein 86), Q5FVH0 (unknown), P58405 (Striatin 3), Q62667 (Major vault protein), Q66H50 (unknown), Q09167 (splicing factor), Q9JHU5 (Arfaptin 1)."|comment:"Insulin increased GLUT4 interaction with the following proteins:Q9Z1P2 (R-actinin-1), P45592 (Cofilin), Q9QXQ0 (R-actinin-4), P26473 (ADP-ribosylation factor), P26437 (ADP-ribosylation factor),   Q7TNP1 (Basigin 2), Q6P6R2 (Dihydrolipoamide dehydrogenase),   P04797 (GAPDH), Q63081 (Protein disulfide isomerase), P29457 (47 kDa heat shock protein), Q9R1J8 (Leprecan), O88638 (Putative eps protein),   Q64375 (Synaptonemal complex)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:NDPK - Interactions involving proteins containing InterPro domain IPR001564, Nucleoside diphosphate kinase, core.	taxid:10116(rat-l6)|taxid:10116(Rattus norvegicus)	-	2006/02/15	2021/11/30	rogid:PbFY2lfrty8yw40Jq7ShR7xfuV410116	rogid:3TIdKq80z9X+YL8RYDe20FbwymQ10116	intact-crc:44F3A2176D02515F|rigid:9RVm0UBcqQF4k06RGKO89Bg16Q8	false	myc tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P19357	uniprotkb:Q5XIH7	intact:EBI-915426|uniprotkb:P97900|ensembl:ENSRNOP00000023256	intact:EBI-918041|uniprotkb:P70629|uniprotkb:P70630|ensembl:ENSRNOP00000017472	psi-mi:glut4_rat(display_long)|uniprotkb:Glucose transporter type 4, insulin-responsive(gene name synonym)|uniprotkb:Slc2a4(gene name)|psi-mi:Slc2a4(display_short)|uniprotkb:Glut4(gene name synonym)	psi-mi:phb2_rat(display_long)|uniprotkb:B-cell receptor-associated protein BAP37(gene name synonym)|uniprotkb:Phb2(gene name)|psi-mi:Phb2(display_short)|uniprotkb:Bcap37(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Foster et al. (2006)	pubmed:16396496|mint:MINT-5218203	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-921030	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2711|refseq:NP_036883.1|refseq:XP_006246658.1|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007611"(learning or memory)|go:"GO:0007614"(short-term memory)|go:"GO:0007616"(long-term memory)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010021"(amylopectin biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031550"(positive regulation of brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044381"(glucose import in response to insulin stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046323"(glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0098694"(regulation of synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0098793"(presynapse)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002441("Glucose transporter, type 4 (GLUT4)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-189200|ensembl:ENSRNOG00000017226(gene)|ensembl:ENSRNOT00000023256(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)	rgd:620203|refseq:NP_001013053.1|ensembl:ENSRNOG00000012999(gene)|ensembl:ENSRNOT00000017472(transcript)|go:"GO:0000423"(mitophagy)|go:"GO:0002639"(positive regulation of immunoglobulin production)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0007062"(sister chromatid cohesion)|go:"GO:0007202"(activation of phospholipase C activity)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0009611"(response to wounding)|go:"GO:0009986"(cell surface)|go:"GO:0016363"(nuclear matrix)|go:"GO:0016477"(cell migration)|go:"GO:0023035"(CD40 signaling pathway)|go:"GO:0031536"(positive regulation of exit from mitosis)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033147"(negative regulation of intracellular estrogen receptor signaling pathway)|go:"GO:0033218"(amide binding)|go:"GO:0033600"(negative regulation of mammary gland epithelial cell proliferation)|go:"GO:0035632"(mitochondrial prohibitin complex)|go:"GO:0039520"(induction by virus of host autophagy)|go:"GO:0039529"(RIG-I signaling pathway)|go:"GO:0042113"(B cell activation)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0046625"(sphingolipid binding)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048786"(presynaptic active zone)|go:"GO:0050821"(protein stabilization)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0060744"(mammary gland branching involved in thelarche)|go:"GO:0060749"(mammary gland alveolus development)|go:"GO:0060762"(regulation of branching involved in mammary gland duct morphogenesis)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071300"(cellular response to retinoic acid)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071944"(cell periphery)|go:"GO:0098800"(inner mitochondrial membrane protein complex)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0098982"(GABA-ergic synapse)|go:"GO:0140374"(antiviral innate immune response)|go:"GO:1900208"(regulation of cardiolipin metabolic process)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:1902808"(positive regulation of cell cycle G1/S phase transition)|go:"GO:1904959"(regulation of cytochrome-c oxidase activity)|go:"GO:1990051"(activation of protein kinase C activity)|interpro:IPR000163(Prohibitin)|interpro:IPR001107(Band 7 protein)|interpro:IPR036013|mint:Q5XIH7|reactome:R-RNO-8949664|go:"GO:0014069"(postsynaptic density)	-	-	-	caution:"The participant EBI-349571(P68370) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919386(Q7TP47) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920972(Q5XIP9) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-916419(P11980) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919578(Q8R491) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920554(Q5U3Z7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920647(Q5U2X8) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920585(Q7TP24) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-779677(P05426) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-915744(P02454) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|agonist:Insulin was shown to increase or decrease GLUT4 protein interactions in specific cases.|comment:"Insulin decreased GLUT4 interactions with the following proteins: Q9ER30 (Sarcosin), P09527 (Rab-7), O88960 (N-ethylmaleimide sensitive), P09456 (PKA I regulatory subunit), P27881 (Hexokinase type II), P07872 (Acyl-coenzyme A oxidase), Q6DGF1 (Isocitrate dehydrogenase), Q9EQX9 (Ubiquitin-conjugating), Q63446 (Polyubiquitin), P24268 (Cathepsin D), Q91XW0 (Heat shock protein 86), Q5FVH0 (unknown), P58405 (Striatin 3), Q62667 (Major vault protein), Q66H50 (unknown), Q09167 (splicing factor), Q9JHU5 (Arfaptin 1)."|comment:"Insulin increased GLUT4 interaction with the following proteins:Q9Z1P2 (R-actinin-1), P45592 (Cofilin), Q9QXQ0 (R-actinin-4), P26473 (ADP-ribosylation factor), P26437 (ADP-ribosylation factor),   Q7TNP1 (Basigin 2), Q6P6R2 (Dihydrolipoamide dehydrogenase),   P04797 (GAPDH), Q63081 (Protein disulfide isomerase), P29457 (47 kDa heat shock protein), Q9R1J8 (Leprecan), O88638 (Putative eps protein),   Q64375 (Synaptonemal complex)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:NDPK - Interactions involving proteins containing InterPro domain IPR001564, Nucleoside diphosphate kinase, core.	taxid:10116(rat-l6)|taxid:10116(Rattus norvegicus)	-	2006/02/15	2021/11/30	rogid:PbFY2lfrty8yw40Jq7ShR7xfuV410116	rogid:VjRorTWSSei7yX+hNlgLqK2S49810116	intact-crc:44F3A2176D02515F|rigid:9RVm0UBcqQF4k06RGKO89Bg16Q8	false	myc tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P19357	uniprotkb:P70550	intact:EBI-915426|uniprotkb:P97900|ensembl:ENSRNOP00000023256	intact:EBI-918032|ensembl:ENSRNOP00000024287	psi-mi:glut4_rat(display_long)|uniprotkb:Glucose transporter type 4, insulin-responsive(gene name synonym)|uniprotkb:Slc2a4(gene name)|psi-mi:Slc2a4(display_short)|uniprotkb:Glut4(gene name synonym)	psi-mi:rab8b_rat(display_long)|uniprotkb:Rab8b(gene name)|psi-mi:Rab8b(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Foster et al. (2006)	pubmed:16396496|mint:MINT-5218203	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-921030	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2711|refseq:NP_036883.1|refseq:XP_006246658.1|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007611"(learning or memory)|go:"GO:0007614"(short-term memory)|go:"GO:0007616"(long-term memory)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010021"(amylopectin biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031550"(positive regulation of brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044381"(glucose import in response to insulin stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046323"(glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0098694"(regulation of synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0098793"(presynapse)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002441("Glucose transporter, type 4 (GLUT4)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-189200|ensembl:ENSRNOG00000017226(gene)|ensembl:ENSRNOT00000023256(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)	rgd:628764|refseq:NP_695229.1|ensembl:ENSRNOG00000018009(gene)|ensembl:ENSRNOT00000024286(transcript)|go:"GO:0003924"(GTPase activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005525"(GTP binding)|go:"GO:0005768"(endosome)|go:"GO:0005778"(peroxisomal membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0006904"(vesicle docking involved in exocytosis)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0009306"(protein secretion)|go:"GO:0016604"(nuclear body)|go:"GO:0017157"(regulation of exocytosis)|go:"GO:0019003"(GDP binding)|go:"GO:0019882"(antigen processing and presentation)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030670"(phagocytic vesicle membrane)|go:"GO:0030911"(TPR domain binding)|go:"GO:0031346"(positive regulation of cell projection organization)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0045046"(protein import into peroxisome membrane)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0048210"(Golgi vesicle fusion to target membrane)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051286"(cell tip)|go:"GO:0051461"(positive regulation of corticotropin secretion)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0098793"(presynapse)|go:"GO:0150115"(cell-substrate junction organization)|interpro:IPR001806(Ras GTPase)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR027417|reactome:R-RNO-8854214|reactome:R-RNO-8873719|reactome:R-RNO-8876198	-	-	-	caution:"The participant EBI-349571(P68370) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919386(Q7TP47) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920972(Q5XIP9) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-916419(P11980) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919578(Q8R491) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920554(Q5U3Z7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920647(Q5U2X8) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920585(Q7TP24) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-779677(P05426) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-915744(P02454) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|agonist:Insulin was shown to increase or decrease GLUT4 protein interactions in specific cases.|comment:"Insulin decreased GLUT4 interactions with the following proteins: Q9ER30 (Sarcosin), P09527 (Rab-7), O88960 (N-ethylmaleimide sensitive), P09456 (PKA I regulatory subunit), P27881 (Hexokinase type II), P07872 (Acyl-coenzyme A oxidase), Q6DGF1 (Isocitrate dehydrogenase), Q9EQX9 (Ubiquitin-conjugating), Q63446 (Polyubiquitin), P24268 (Cathepsin D), Q91XW0 (Heat shock protein 86), Q5FVH0 (unknown), P58405 (Striatin 3), Q62667 (Major vault protein), Q66H50 (unknown), Q09167 (splicing factor), Q9JHU5 (Arfaptin 1)."|comment:"Insulin increased GLUT4 interaction with the following proteins:Q9Z1P2 (R-actinin-1), P45592 (Cofilin), Q9QXQ0 (R-actinin-4), P26473 (ADP-ribosylation factor), P26437 (ADP-ribosylation factor),   Q7TNP1 (Basigin 2), Q6P6R2 (Dihydrolipoamide dehydrogenase),   P04797 (GAPDH), Q63081 (Protein disulfide isomerase), P29457 (47 kDa heat shock protein), Q9R1J8 (Leprecan), O88638 (Putative eps protein),   Q64375 (Synaptonemal complex)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:NDPK - Interactions involving proteins containing InterPro domain IPR001564, Nucleoside diphosphate kinase, core.	taxid:10116(rat-l6)|taxid:10116(Rattus norvegicus)	-	2006/02/15	2021/11/30	rogid:PbFY2lfrty8yw40Jq7ShR7xfuV410116	rogid:bRfYongYDkw/3XyTJ8jMVUZ001E10116	intact-crc:44F3A2176D02515F|rigid:9RVm0UBcqQF4k06RGKO89Bg16Q8	false	myc tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P19357	uniprotkb:P70500	intact:EBI-915426|uniprotkb:P97900|ensembl:ENSRNOP00000023256	intact:EBI-918024|ensembl:ENSRNOP00000013691|ensembl:ENSRNOP00000070871	psi-mi:glut4_rat(display_long)|uniprotkb:Glucose transporter type 4, insulin-responsive(gene name synonym)|uniprotkb:Slc2a4(gene name)|psi-mi:Slc2a4(display_short)|uniprotkb:Glut4(gene name synonym)	psi-mi:cdipt_rat(display_long)|uniprotkb:Phosphatidylinositol synthase(gene name synonym)|uniprotkb:Cdipt(gene name)|psi-mi:Cdipt(display_short)|uniprotkb:Pis1(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Foster et al. (2006)	pubmed:16396496|mint:MINT-5218203	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-921030	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2711|refseq:NP_036883.1|refseq:XP_006246658.1|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007611"(learning or memory)|go:"GO:0007614"(short-term memory)|go:"GO:0007616"(long-term memory)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010021"(amylopectin biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031550"(positive regulation of brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044381"(glucose import in response to insulin stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046323"(glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0098694"(regulation of synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0098793"(presynapse)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002441("Glucose transporter, type 4 (GLUT4)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-189200|ensembl:ENSRNOG00000017226(gene)|ensembl:ENSRNOT00000023256(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)	rgd:620576|refseq:NP_620254.1|refseq:XP_006230270.1|ensembl:ENSRNOG00000024144(gene)|ensembl:ENSRNOT00000013691(transcript)|ensembl:ENSRNOT00000091295(transcript)|go:"GO:0003881"(CDP-diacylglycerol-inositol 3-phosphatidyltransferase activity)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0006661"(phosphatidylinositol biosynthetic process)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019992"(diacylglycerol binding)|go:"GO:0030145"(manganese ion binding)|go:"GO:0030246"(carbohydrate binding)|go:"GO:0043178"(alcohol binding)|go:"GO:0046341"(CDP-diacylglycerol metabolic process)|interpro:IPR000462(CDP-alcohol phosphatidyltransferase)|interpro:IPR014387(CDP-diacylglycerol-inositol 3-phosphatidyltransferase, eukaryote)|interpro:IPR043130|reactome:R-RNO-1483226	-	-	-	caution:"The participant EBI-349571(P68370) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919386(Q7TP47) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920972(Q5XIP9) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-916419(P11980) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919578(Q8R491) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920554(Q5U3Z7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920647(Q5U2X8) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920585(Q7TP24) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-779677(P05426) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-915744(P02454) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|agonist:Insulin was shown to increase or decrease GLUT4 protein interactions in specific cases.|comment:"Insulin decreased GLUT4 interactions with the following proteins: Q9ER30 (Sarcosin), P09527 (Rab-7), O88960 (N-ethylmaleimide sensitive), P09456 (PKA I regulatory subunit), P27881 (Hexokinase type II), P07872 (Acyl-coenzyme A oxidase), Q6DGF1 (Isocitrate dehydrogenase), Q9EQX9 (Ubiquitin-conjugating), Q63446 (Polyubiquitin), P24268 (Cathepsin D), Q91XW0 (Heat shock protein 86), Q5FVH0 (unknown), P58405 (Striatin 3), Q62667 (Major vault protein), Q66H50 (unknown), Q09167 (splicing factor), Q9JHU5 (Arfaptin 1)."|comment:"Insulin increased GLUT4 interaction with the following proteins:Q9Z1P2 (R-actinin-1), P45592 (Cofilin), Q9QXQ0 (R-actinin-4), P26473 (ADP-ribosylation factor), P26437 (ADP-ribosylation factor),   Q7TNP1 (Basigin 2), Q6P6R2 (Dihydrolipoamide dehydrogenase),   P04797 (GAPDH), Q63081 (Protein disulfide isomerase), P29457 (47 kDa heat shock protein), Q9R1J8 (Leprecan), O88638 (Putative eps protein),   Q64375 (Synaptonemal complex)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:NDPK - Interactions involving proteins containing InterPro domain IPR001564, Nucleoside diphosphate kinase, core.	taxid:10116(rat-l6)|taxid:10116(Rattus norvegicus)	-	2006/02/15	2021/11/30	rogid:PbFY2lfrty8yw40Jq7ShR7xfuV410116	rogid:nJ8zr4N35d1CrpwwqKNfDzzwJuk10116	intact-crc:44F3A2176D02515F|rigid:9RVm0UBcqQF4k06RGKO89Bg16Q8	false	myc tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P19357	uniprotkb:P70490	intact:EBI-915426|uniprotkb:P97900|ensembl:ENSRNOP00000023256	intact:EBI-918012|ensembl:ENSRNOP00000024253	psi-mi:glut4_rat(display_long)|uniprotkb:Glucose transporter type 4, insulin-responsive(gene name synonym)|uniprotkb:Slc2a4(gene name)|psi-mi:Slc2a4(display_short)|uniprotkb:Glut4(gene name synonym)	psi-mi:mfgm_rat(display_long)|uniprotkb:Milk fat globule-EGF factor 8(gene name synonym)|uniprotkb:O-acetyl GD3 ganglioside synthase(gene name synonym)|uniprotkb:MFGM(gene name synonym)|uniprotkb:Mfge8(gene name)|psi-mi:Mfge8(display_short)|uniprotkb:Ags(gene name synonym)|uniprotkb:SED1(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Foster et al. (2006)	pubmed:16396496|mint:MINT-5218203	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-921030	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2711|refseq:NP_036883.1|refseq:XP_006246658.1|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007611"(learning or memory)|go:"GO:0007614"(short-term memory)|go:"GO:0007616"(long-term memory)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010021"(amylopectin biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031550"(positive regulation of brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044381"(glucose import in response to insulin stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046323"(glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0098694"(regulation of synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0098793"(presynapse)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002441("Glucose transporter, type 4 (GLUT4)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-189200|ensembl:ENSRNOG00000017226(gene)|ensembl:ENSRNOT00000023256(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)	refseq:NP_001035276.1|rgd:3083|refseq:NP_036943.1|ensembl:ENSRNOG00000017510(gene)|ensembl:ENSRNOT00000024253(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001786"(phosphatidylserine binding)|go:"GO:0002080"(acrosomal membrane)|go:"GO:0005178"(integrin binding)|go:"GO:0005615"(extracellular space)|go:"GO:0006910"(phagocytosis, recognition)|go:"GO:0006911"(phagocytosis, engulfment)|go:"GO:0007155"(cell adhesion)|go:"GO:0007338"(single fertilization)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008429"(phosphatidylethanolamine binding)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0019897"(extrinsic component of plasma membrane)|go:"GO:0043277"(apoptotic cell clearance)|go:"GO:0043627"(response to estrogen)|go:"GO:0050766"(positive regulation of phagocytosis)|interpro:IPR000421(Coagulation factor 5/8 type, C-terminal)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR008979(Galactose-binding like)|reactome:R-RNO-381426|reactome:R-RNO-8957275	-	-	-	caution:"The participant EBI-349571(P68370) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919386(Q7TP47) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920972(Q5XIP9) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-916419(P11980) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919578(Q8R491) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920554(Q5U3Z7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920647(Q5U2X8) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920585(Q7TP24) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-779677(P05426) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-915744(P02454) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|agonist:Insulin was shown to increase or decrease GLUT4 protein interactions in specific cases.|comment:"Insulin decreased GLUT4 interactions with the following proteins: Q9ER30 (Sarcosin), P09527 (Rab-7), O88960 (N-ethylmaleimide sensitive), P09456 (PKA I regulatory subunit), P27881 (Hexokinase type II), P07872 (Acyl-coenzyme A oxidase), Q6DGF1 (Isocitrate dehydrogenase), Q9EQX9 (Ubiquitin-conjugating), Q63446 (Polyubiquitin), P24268 (Cathepsin D), Q91XW0 (Heat shock protein 86), Q5FVH0 (unknown), P58405 (Striatin 3), Q62667 (Major vault protein), Q66H50 (unknown), Q09167 (splicing factor), Q9JHU5 (Arfaptin 1)."|comment:"Insulin increased GLUT4 interaction with the following proteins:Q9Z1P2 (R-actinin-1), P45592 (Cofilin), Q9QXQ0 (R-actinin-4), P26473 (ADP-ribosylation factor), P26437 (ADP-ribosylation factor),   Q7TNP1 (Basigin 2), Q6P6R2 (Dihydrolipoamide dehydrogenase),   P04797 (GAPDH), Q63081 (Protein disulfide isomerase), P29457 (47 kDa heat shock protein), Q9R1J8 (Leprecan), O88638 (Putative eps protein),   Q64375 (Synaptonemal complex)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:NDPK - Interactions involving proteins containing InterPro domain IPR001564, Nucleoside diphosphate kinase, core.	taxid:10116(rat-l6)|taxid:10116(Rattus norvegicus)	-	2006/02/15	2021/11/30	rogid:PbFY2lfrty8yw40Jq7ShR7xfuV410116	rogid:C7LHVOlzuI6C53Fk14AV5MF4FAc10116	intact-crc:44F3A2176D02515F|rigid:9RVm0UBcqQF4k06RGKO89Bg16Q8	false	myc tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P19357	uniprotkb:P70470	intact:EBI-915426|uniprotkb:P97900|ensembl:ENSRNOP00000023256	intact:EBI-918004|ensembl:ENSRNOP00000011312	psi-mi:glut4_rat(display_long)|uniprotkb:Glucose transporter type 4, insulin-responsive(gene name synonym)|uniprotkb:Slc2a4(gene name)|psi-mi:Slc2a4(display_short)|uniprotkb:Glut4(gene name synonym)	psi-mi:lypa1_rat(display_long)|uniprotkb:Lysophospholipase 1(gene name synonym)|uniprotkb:Lysophospholipase I(gene name synonym)|uniprotkb:Lypla1(gene name)|psi-mi:Lypla1(display_short)|uniprotkb:Apt1(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Foster et al. (2006)	pubmed:16396496|mint:MINT-5218203	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-921030	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2711|refseq:NP_036883.1|refseq:XP_006246658.1|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007611"(learning or memory)|go:"GO:0007614"(short-term memory)|go:"GO:0007616"(long-term memory)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010021"(amylopectin biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031550"(positive regulation of brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044381"(glucose import in response to insulin stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046323"(glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0098694"(regulation of synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0098793"(presynapse)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002441("Glucose transporter, type 4 (GLUT4)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-189200|ensembl:ENSRNOG00000017226(gene)|ensembl:ENSRNOT00000023256(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)	rgd:3025|refseq:NP_037138.1|ensembl:ENSRNOG00000008320(gene)|ensembl:ENSRNOT00000011312(transcript)|go:"GO:0002084"(protein depalmitoylation)|go:"GO:0004620"(phospholipase activity)|go:"GO:0004622"(lysophospholipase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006631"(fatty acid metabolic process)|go:"GO:0008474"("palmitoyl-(protein) hydrolase activity")|go:"GO:0016298"(lipase activity)|go:"GO:0031965"(nuclear membrane)|go:"GO:0042997"(negative regulation of Golgi to plasma membrane protein transport)|go:"GO:0052689"(carboxylic ester hydrolase activity)|interpro:IPR003140(Phospholipase/carboxylesterase)|interpro:IPR029058|reactome:R-RNO-203615|reactome:R-RNO-9648002	-	-	-	caution:"The participant EBI-349571(P68370) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919386(Q7TP47) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920972(Q5XIP9) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-916419(P11980) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919578(Q8R491) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920554(Q5U3Z7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920647(Q5U2X8) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920585(Q7TP24) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-779677(P05426) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-915744(P02454) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|agonist:Insulin was shown to increase or decrease GLUT4 protein interactions in specific cases.|comment:"Insulin decreased GLUT4 interactions with the following proteins: Q9ER30 (Sarcosin), P09527 (Rab-7), O88960 (N-ethylmaleimide sensitive), P09456 (PKA I regulatory subunit), P27881 (Hexokinase type II), P07872 (Acyl-coenzyme A oxidase), Q6DGF1 (Isocitrate dehydrogenase), Q9EQX9 (Ubiquitin-conjugating), Q63446 (Polyubiquitin), P24268 (Cathepsin D), Q91XW0 (Heat shock protein 86), Q5FVH0 (unknown), P58405 (Striatin 3), Q62667 (Major vault protein), Q66H50 (unknown), Q09167 (splicing factor), Q9JHU5 (Arfaptin 1)."|comment:"Insulin increased GLUT4 interaction with the following proteins:Q9Z1P2 (R-actinin-1), P45592 (Cofilin), Q9QXQ0 (R-actinin-4), P26473 (ADP-ribosylation factor), P26437 (ADP-ribosylation factor),   Q7TNP1 (Basigin 2), Q6P6R2 (Dihydrolipoamide dehydrogenase),   P04797 (GAPDH), Q63081 (Protein disulfide isomerase), P29457 (47 kDa heat shock protein), Q9R1J8 (Leprecan), O88638 (Putative eps protein),   Q64375 (Synaptonemal complex)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:NDPK - Interactions involving proteins containing InterPro domain IPR001564, Nucleoside diphosphate kinase, core.	taxid:10116(rat-l6)|taxid:10116(Rattus norvegicus)	-	2006/02/15	2021/11/30	rogid:PbFY2lfrty8yw40Jq7ShR7xfuV410116	rogid:ZwyLPWHNmoCWzVFiRov8y3vpo9s10116	intact-crc:44F3A2176D02515F|rigid:9RVm0UBcqQF4k06RGKO89Bg16Q8	false	myc tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P19357	uniprotkb:P62718	intact:EBI-915426|uniprotkb:P97900|ensembl:ENSRNOP00000023256	intact:EBI-917998|uniprotkb:P11249|ensembl:ENSRNOP00000025421	psi-mi:glut4_rat(display_long)|uniprotkb:Glucose transporter type 4, insulin-responsive(gene name synonym)|uniprotkb:Slc2a4(gene name)|psi-mi:Slc2a4(display_short)|uniprotkb:Glut4(gene name synonym)	psi-mi:rl18a_rat(display_long)|uniprotkb:Rpl18a(gene name)|psi-mi:Rpl18a(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Foster et al. (2006)	pubmed:16396496|mint:MINT-5218203	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-921030	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2711|refseq:NP_036883.1|refseq:XP_006246658.1|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007611"(learning or memory)|go:"GO:0007614"(short-term memory)|go:"GO:0007616"(long-term memory)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010021"(amylopectin biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031550"(positive regulation of brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044381"(glucose import in response to insulin stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046323"(glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0098694"(regulation of synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0098793"(presynapse)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002441("Glucose transporter, type 4 (GLUT4)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-189200|ensembl:ENSRNOG00000017226(gene)|ensembl:ENSRNOT00000023256(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)	rgd:1302976|refseq:NP_997675.1|ensembl:ENSRNOG00000018795(gene)|ensembl:ENSRNOT00000025421(transcript)|go:"GO:0002181"(cytoplasmic translation)|go:"GO:0003735"(structural constituent of ribosome)|go:"GO:0005840"(ribosome)|go:"GO:0014069"(postsynaptic density)|go:"GO:0022625"(cytosolic large ribosomal subunit)|go:"GO:0022626"(cytosolic ribosome)|go:"GO:0042788"(polysomal ribosome)|go:"GO:0045202"(synapse)|go:"GO:0097327"(response to antineoplastic agent)|interpro:IPR021138|interpro:IPR023573|interpro:IPR028877|reactome:R-RNO-156827|reactome:R-RNO-1799339|reactome:R-RNO-6791226|reactome:R-RNO-72689|reactome:R-RNO-72706|reactome:R-RNO-975956|reactome:R-RNO-975957	-	-	-	caution:"The participant EBI-349571(P68370) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919386(Q7TP47) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920972(Q5XIP9) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-916419(P11980) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919578(Q8R491) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920554(Q5U3Z7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920647(Q5U2X8) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920585(Q7TP24) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-779677(P05426) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-915744(P02454) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|agonist:Insulin was shown to increase or decrease GLUT4 protein interactions in specific cases.|comment:"Insulin decreased GLUT4 interactions with the following proteins: Q9ER30 (Sarcosin), P09527 (Rab-7), O88960 (N-ethylmaleimide sensitive), P09456 (PKA I regulatory subunit), P27881 (Hexokinase type II), P07872 (Acyl-coenzyme A oxidase), Q6DGF1 (Isocitrate dehydrogenase), Q9EQX9 (Ubiquitin-conjugating), Q63446 (Polyubiquitin), P24268 (Cathepsin D), Q91XW0 (Heat shock protein 86), Q5FVH0 (unknown), P58405 (Striatin 3), Q62667 (Major vault protein), Q66H50 (unknown), Q09167 (splicing factor), Q9JHU5 (Arfaptin 1)."|comment:"Insulin increased GLUT4 interaction with the following proteins:Q9Z1P2 (R-actinin-1), P45592 (Cofilin), Q9QXQ0 (R-actinin-4), P26473 (ADP-ribosylation factor), P26437 (ADP-ribosylation factor),   Q7TNP1 (Basigin 2), Q6P6R2 (Dihydrolipoamide dehydrogenase),   P04797 (GAPDH), Q63081 (Protein disulfide isomerase), P29457 (47 kDa heat shock protein), Q9R1J8 (Leprecan), O88638 (Putative eps protein),   Q64375 (Synaptonemal complex)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:NDPK - Interactions involving proteins containing InterPro domain IPR001564, Nucleoside diphosphate kinase, core.	taxid:10116(rat-l6)|taxid:10116(Rattus norvegicus)	-	2006/02/15	2021/11/30	rogid:PbFY2lfrty8yw40Jq7ShR7xfuV410116	rogid:HMbe4GVCuVZs0/90BMnEgpOqeiA10116	intact-crc:44F3A2176D02515F|rigid:9RVm0UBcqQF4k06RGKO89Bg16Q8	false	myc tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P19357	uniprotkb:P62716	intact:EBI-915426|uniprotkb:P97900|ensembl:ENSRNOP00000023256	intact:EBI-917965|uniprotkb:P11082|uniprotkb:Q6LDK0|ensembl:ENSRNOP00000020663	psi-mi:glut4_rat(display_long)|uniprotkb:Glucose transporter type 4, insulin-responsive(gene name synonym)|uniprotkb:Slc2a4(gene name)|psi-mi:Slc2a4(display_short)|uniprotkb:Glut4(gene name synonym)	psi-mi:pp2ab_rat(display_long)|uniprotkb:Ppp2cb(gene name)|psi-mi:Ppp2cb(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Foster et al. (2006)	pubmed:16396496|mint:MINT-5218203	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-921030	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2711|refseq:NP_036883.1|refseq:XP_006246658.1|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007611"(learning or memory)|go:"GO:0007614"(short-term memory)|go:"GO:0007616"(long-term memory)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010021"(amylopectin biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031550"(positive regulation of brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044381"(glucose import in response to insulin stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046323"(glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0098694"(regulation of synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0098793"(presynapse)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002441("Glucose transporter, type 4 (GLUT4)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-189200|ensembl:ENSRNOG00000017226(gene)|ensembl:ENSRNOT00000023256(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)	rgd:3381|refseq:NP_058736.1|ensembl:ENSRNOG00000015182(gene)|ensembl:ENSRNOT00000020663(transcript)|go:"GO:0000159"(protein phosphatase type 2A complex)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0000922"(spindle pole)|go:"GO:0004721"(phosphoprotein phosphatase activity)|go:"GO:0004722"(protein serine/threonine phosphatase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008637"(apoptotic mitochondrial changes)|go:"GO:0010288"(response to lead ion)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0046580"(negative regulation of Ras protein signal transduction)|go:"GO:0046677"(response to antibiotic)|go:"GO:0046872"(metal ion binding)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0106306"|go:"GO:0106307"|go:"GO:1904528"(positive regulation of microtubule binding)|interpro:IPR004843(Metallophosphoesterase)|interpro:IPR006186("Serine/threonine-specific protein phosphatase and bis(5-nucleosyl)-tetraphosphatase")|interpro:IPR029052|reactome:R-RNO-113501|reactome:R-RNO-1295596|reactome:R-RNO-141444|reactome:R-RNO-180024|reactome:R-RNO-195253|reactome:R-RNO-196299|reactome:R-RNO-198753|reactome:R-RNO-202670|reactome:R-RNO-2467813|reactome:R-RNO-2500257|reactome:R-RNO-389513|reactome:R-RNO-4641262|reactome:R-RNO-5663220|reactome:R-RNO-5673000|reactome:R-RNO-5675221|reactome:R-RNO-6804757|reactome:R-RNO-6811558|reactome:R-RNO-68877|reactome:R-RNO-69231|reactome:R-RNO-69273|reactome:R-RNO-9648025	-	-	-	caution:"The participant EBI-349571(P68370) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919386(Q7TP47) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920972(Q5XIP9) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-916419(P11980) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919578(Q8R491) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920554(Q5U3Z7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920647(Q5U2X8) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920585(Q7TP24) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-779677(P05426) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-915744(P02454) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|agonist:Insulin was shown to increase or decrease GLUT4 protein interactions in specific cases.|comment:"Insulin decreased GLUT4 interactions with the following proteins: Q9ER30 (Sarcosin), P09527 (Rab-7), O88960 (N-ethylmaleimide sensitive), P09456 (PKA I regulatory subunit), P27881 (Hexokinase type II), P07872 (Acyl-coenzyme A oxidase), Q6DGF1 (Isocitrate dehydrogenase), Q9EQX9 (Ubiquitin-conjugating), Q63446 (Polyubiquitin), P24268 (Cathepsin D), Q91XW0 (Heat shock protein 86), Q5FVH0 (unknown), P58405 (Striatin 3), Q62667 (Major vault protein), Q66H50 (unknown), Q09167 (splicing factor), Q9JHU5 (Arfaptin 1)."|comment:"Insulin increased GLUT4 interaction with the following proteins:Q9Z1P2 (R-actinin-1), P45592 (Cofilin), Q9QXQ0 (R-actinin-4), P26473 (ADP-ribosylation factor), P26437 (ADP-ribosylation factor),   Q7TNP1 (Basigin 2), Q6P6R2 (Dihydrolipoamide dehydrogenase),   P04797 (GAPDH), Q63081 (Protein disulfide isomerase), P29457 (47 kDa heat shock protein), Q9R1J8 (Leprecan), O88638 (Putative eps protein),   Q64375 (Synaptonemal complex)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:NDPK - Interactions involving proteins containing InterPro domain IPR001564, Nucleoside diphosphate kinase, core.	taxid:10116(rat-l6)|taxid:10116(Rattus norvegicus)	-	2006/02/15	2021/11/30	rogid:PbFY2lfrty8yw40Jq7ShR7xfuV410116	rogid:ZWmB6it7rr0BS5sy38IxZ9QdR7U10116	intact-crc:44F3A2176D02515F|rigid:9RVm0UBcqQF4k06RGKO89Bg16Q8	false	myc tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P19357	uniprotkb:P62703	intact:EBI-915426|uniprotkb:P97900|ensembl:ENSRNOP00000023256	intact:EBI-354282|uniprotkb:P12631|uniprotkb:P12750|uniprotkb:P27576|uniprotkb:Q14727|uniprotkb:P55831|ensembl:ENSRNOP00000067969	psi-mi:glut4_rat(display_long)|uniprotkb:Glucose transporter type 4, insulin-responsive(gene name synonym)|uniprotkb:Slc2a4(gene name)|psi-mi:Slc2a4(display_short)|uniprotkb:Glut4(gene name synonym)	psi-mi:rs4x_rat(display_long)|uniprotkb:Rps4x(gene name)|psi-mi:Rps4x(display_short)|uniprotkb:Rps4(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Foster et al. (2006)	pubmed:16396496|mint:MINT-5218203	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-921030	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2711|refseq:NP_036883.1|refseq:XP_006246658.1|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007611"(learning or memory)|go:"GO:0007614"(short-term memory)|go:"GO:0007616"(long-term memory)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010021"(amylopectin biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031550"(positive regulation of brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044381"(glucose import in response to insulin stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046323"(glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0098694"(regulation of synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0098793"(presynapse)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002441("Glucose transporter, type 4 (GLUT4)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-189200|ensembl:ENSRNOG00000017226(gene)|ensembl:ENSRNOT00000023256(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)	refseq:NP_001007601.1|rgd:2324318|ensembl:ENSRNOG00000003201(gene)|go:"GO:0019843"(rRNA binding)|go:"GO:0022626"(cytosolic ribosome)|go:"GO:0022627"(cytosolic small ribosomal subunit)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0045202"(synapse)|go:"GO:0045471"(response to ethanol)|ensembl:ENSRNOT00000076978(transcript)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0003723"(RNA binding)|go:"GO:0003735"(structural constituent of ribosome)|go:"GO:0005840"(ribosome)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR000876(Ribosomal protein S4e)|interpro:IPR002942(RNA-binding S4)|interpro:IPR005824(KOW)|interpro:IPR013843(Ribosomal protein S4e, N-terminal)|interpro:IPR013845(Ribosomal protein S4e, central)|go:"GO:0005844"(polysome)|go:"GO:0006412"(translation)|interpro:IPR014722(Translation protein SH3-like, subgroup)|interpro:IPR018199|interpro:IPR032277|interpro:IPR036986|interpro:IPR038237|interpro:IPR041982|mint:P62703|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0015935"(small ribosomal subunit)|reactome:R-RNO-156827|reactome:R-RNO-1799339|reactome:R-RNO-6791226|reactome:R-RNO-72649|reactome:R-RNO-72689|reactome:R-RNO-72695|reactome:R-RNO-72702|reactome:R-RNO-72706|reactome:R-RNO-975956|reactome:R-RNO-975957	-	-	-	caution:"The participant EBI-349571(P68370) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919386(Q7TP47) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920972(Q5XIP9) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-916419(P11980) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919578(Q8R491) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920554(Q5U3Z7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920647(Q5U2X8) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920585(Q7TP24) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-779677(P05426) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-915744(P02454) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|agonist:Insulin was shown to increase or decrease GLUT4 protein interactions in specific cases.|comment:"Insulin decreased GLUT4 interactions with the following proteins: Q9ER30 (Sarcosin), P09527 (Rab-7), O88960 (N-ethylmaleimide sensitive), P09456 (PKA I regulatory subunit), P27881 (Hexokinase type II), P07872 (Acyl-coenzyme A oxidase), Q6DGF1 (Isocitrate dehydrogenase), Q9EQX9 (Ubiquitin-conjugating), Q63446 (Polyubiquitin), P24268 (Cathepsin D), Q91XW0 (Heat shock protein 86), Q5FVH0 (unknown), P58405 (Striatin 3), Q62667 (Major vault protein), Q66H50 (unknown), Q09167 (splicing factor), Q9JHU5 (Arfaptin 1)."|comment:"Insulin increased GLUT4 interaction with the following proteins:Q9Z1P2 (R-actinin-1), P45592 (Cofilin), Q9QXQ0 (R-actinin-4), P26473 (ADP-ribosylation factor), P26437 (ADP-ribosylation factor),   Q7TNP1 (Basigin 2), Q6P6R2 (Dihydrolipoamide dehydrogenase),   P04797 (GAPDH), Q63081 (Protein disulfide isomerase), P29457 (47 kDa heat shock protein), Q9R1J8 (Leprecan), O88638 (Putative eps protein),   Q64375 (Synaptonemal complex)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:NDPK - Interactions involving proteins containing InterPro domain IPR001564, Nucleoside diphosphate kinase, core.	taxid:10116(rat-l6)|taxid:10116(Rattus norvegicus)	-	2006/02/15	2021/11/30	rogid:PbFY2lfrty8yw40Jq7ShR7xfuV410116	rogid:2ZuLXqBSDkK0CtN3mnIDoFAR8yI10116	intact-crc:44F3A2176D02515F|rigid:9RVm0UBcqQF4k06RGKO89Bg16Q8	false	myc tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P19357	uniprotkb:P62630	intact:EBI-915426|uniprotkb:P97900|ensembl:ENSRNOP00000023256	intact:EBI-917951|uniprotkb:P20001|uniprotkb:Q5BJW8|uniprotkb:Q64718|uniprotkb:Q78ED4|ensembl:ENSRNOP00000013608	psi-mi:glut4_rat(display_long)|uniprotkb:Glucose transporter type 4, insulin-responsive(gene name synonym)|uniprotkb:Slc2a4(gene name)|psi-mi:Slc2a4(display_short)|uniprotkb:Glut4(gene name synonym)	psi-mi:ef1a1_rat(display_long)|uniprotkb:Eukaryotic elongation factor 1 A-1(gene name synonym)|uniprotkb:Elongation factor Tu(gene name synonym)|uniprotkb:Eef1a1(gene name)|psi-mi:Eef1a1(display_short)|uniprotkb:Eef1a(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Foster et al. (2006)	pubmed:16396496|mint:MINT-5218203	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-921030	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2711|refseq:NP_036883.1|refseq:XP_006246658.1|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007611"(learning or memory)|go:"GO:0007614"(short-term memory)|go:"GO:0007616"(long-term memory)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010021"(amylopectin biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031550"(positive regulation of brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044381"(glucose import in response to insulin stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046323"(glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0098694"(regulation of synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0098793"(presynapse)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002441("Glucose transporter, type 4 (GLUT4)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-189200|ensembl:ENSRNOG00000017226(gene)|ensembl:ENSRNOT00000023256(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)	rgd:67387|refseq:NP_787032.1|ensembl:ENSRNOG00000009439(gene)|ensembl:ENSRNOT00000013608(transcript)|go:"GO:0000049"(tRNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0003746"(translation elongation factor activity)|go:"GO:0003924"(GTPase activity)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005525"(GTP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006412"(translation)|go:"GO:0006414"(translational elongation)|go:"GO:0007568"(aging)|go:"GO:0010942"(positive regulation of cell death)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030864"(cortical actin cytoskeleton)|go:"GO:0032587"(ruffle membrane)|go:"GO:0035690"|go:"GO:0042802"(identical protein binding)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|go:"GO:1900022"(regulation of D-erythro-sphingosine kinase activity)|go:"GO:1903427"(negative regulation of reactive oxygen species biosynthetic process)|go:"GO:1990090"(cellular response to nerve growth factor stimulus)|interpro:IPR000795(Protein synthesis factor, GTP-binding)|interpro:IPR004160(Translation elongation factor EFTu/EF1A, C-terminal)|interpro:IPR004161(Translation elongation factor EFTu/EF1A, domain 2)|interpro:IPR004539(Translation elongation factor EF1A, eukaryotic and archaeal)|interpro:IPR009000(Translation elongation and initiation factors/Ribosomal, beta-barrel)|interpro:IPR009001(Translation elongation factor EF1A/initiation factor IF2gamma, C-terminal)|interpro:IPR027417|interpro:IPR031157|mint:P62630|reactome:R-RNO-156842|reactome:R-RNO-3371511|reactome:R-RNO-6798695|reactome:R-RNO-8876725	-	-	-	caution:"The participant EBI-349571(P68370) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919386(Q7TP47) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920972(Q5XIP9) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-916419(P11980) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919578(Q8R491) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920554(Q5U3Z7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920647(Q5U2X8) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920585(Q7TP24) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-779677(P05426) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-915744(P02454) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|agonist:Insulin was shown to increase or decrease GLUT4 protein interactions in specific cases.|comment:"Insulin decreased GLUT4 interactions with the following proteins: Q9ER30 (Sarcosin), P09527 (Rab-7), O88960 (N-ethylmaleimide sensitive), P09456 (PKA I regulatory subunit), P27881 (Hexokinase type II), P07872 (Acyl-coenzyme A oxidase), Q6DGF1 (Isocitrate dehydrogenase), Q9EQX9 (Ubiquitin-conjugating), Q63446 (Polyubiquitin), P24268 (Cathepsin D), Q91XW0 (Heat shock protein 86), Q5FVH0 (unknown), P58405 (Striatin 3), Q62667 (Major vault protein), Q66H50 (unknown), Q09167 (splicing factor), Q9JHU5 (Arfaptin 1)."|comment:"Insulin increased GLUT4 interaction with the following proteins:Q9Z1P2 (R-actinin-1), P45592 (Cofilin), Q9QXQ0 (R-actinin-4), P26473 (ADP-ribosylation factor), P26437 (ADP-ribosylation factor),   Q7TNP1 (Basigin 2), Q6P6R2 (Dihydrolipoamide dehydrogenase),   P04797 (GAPDH), Q63081 (Protein disulfide isomerase), P29457 (47 kDa heat shock protein), Q9R1J8 (Leprecan), O88638 (Putative eps protein),   Q64375 (Synaptonemal complex)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:NDPK - Interactions involving proteins containing InterPro domain IPR001564, Nucleoside diphosphate kinase, core.	taxid:10116(rat-l6)|taxid:10116(Rattus norvegicus)	-	2006/02/15	2021/11/30	rogid:PbFY2lfrty8yw40Jq7ShR7xfuV410116	rogid:85G9Uje743KzA02bB/rmKuq2HbU10116	intact-crc:44F3A2176D02515F|rigid:9RVm0UBcqQF4k06RGKO89Bg16Q8	false	myc tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P19357	uniprotkb:P62628	intact:EBI-915426|uniprotkb:P97900|ensembl:ENSRNOP00000023256	intact:EBI-917939|uniprotkb:O88567|uniprotkb:Q9D812|ensembl:ENSRNOP00000060800	psi-mi:glut4_rat(display_long)|uniprotkb:Glucose transporter type 4, insulin-responsive(gene name synonym)|uniprotkb:Slc2a4(gene name)|psi-mi:Slc2a4(display_short)|uniprotkb:Glut4(gene name synonym)	psi-mi:dlrb1_rat(display_long)|uniprotkb:Dynein light chain 2A, cytoplasmic(gene name synonym)|uniprotkb:Dynein-associated protein Km23(gene name synonym)|uniprotkb:Bithoraxoid-like protein(gene name synonym)|uniprotkb:Dynlrb1(gene name)|psi-mi:Dynlrb1(display_short)|uniprotkb:Dnlc2a(gene name synonym)|uniprotkb:Dncl2a(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Foster et al. (2006)	pubmed:16396496|mint:MINT-5218203	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-921030	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2711|refseq:NP_036883.1|refseq:XP_006246658.1|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007611"(learning or memory)|go:"GO:0007614"(short-term memory)|go:"GO:0007616"(long-term memory)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010021"(amylopectin biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031550"(positive regulation of brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044381"(glucose import in response to insulin stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046323"(glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0098694"(regulation of synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0098793"(presynapse)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002441("Glucose transporter, type 4 (GLUT4)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-189200|ensembl:ENSRNOG00000017226(gene)|ensembl:ENSRNOT00000023256(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)	rgd:619910|refseq:NP_571985.1|ensembl:ENSRNOG00000025715(gene)|ensembl:ENSRNOT00000067854(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005868"(cytoplasmic dynein complex)|go:"GO:0005874"(microtubule)|go:"GO:0007018"(microtubule-based movement)|go:"GO:0007632"(visual behavior)|go:"GO:0008090"(retrograde axonal transport)|go:"GO:0009416"(response to light stimulus)|go:"GO:0042802"(identical protein binding)|go:"GO:0045505"(dynein intermediate chain binding)|go:"GO:1904115"(axon cytoplasm)|interpro:IPR004942(Dynein light chain-related)|interpro:IPR016561(Dynein light chain, roadblock-type)|reactome:R-RNO-5620924	-	-	-	caution:"The participant EBI-349571(P68370) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919386(Q7TP47) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920972(Q5XIP9) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-916419(P11980) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919578(Q8R491) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920554(Q5U3Z7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920647(Q5U2X8) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920585(Q7TP24) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-779677(P05426) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-915744(P02454) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|agonist:Insulin was shown to increase or decrease GLUT4 protein interactions in specific cases.|comment:"Insulin decreased GLUT4 interactions with the following proteins: Q9ER30 (Sarcosin), P09527 (Rab-7), O88960 (N-ethylmaleimide sensitive), P09456 (PKA I regulatory subunit), P27881 (Hexokinase type II), P07872 (Acyl-coenzyme A oxidase), Q6DGF1 (Isocitrate dehydrogenase), Q9EQX9 (Ubiquitin-conjugating), Q63446 (Polyubiquitin), P24268 (Cathepsin D), Q91XW0 (Heat shock protein 86), Q5FVH0 (unknown), P58405 (Striatin 3), Q62667 (Major vault protein), Q66H50 (unknown), Q09167 (splicing factor), Q9JHU5 (Arfaptin 1)."|comment:"Insulin increased GLUT4 interaction with the following proteins:Q9Z1P2 (R-actinin-1), P45592 (Cofilin), Q9QXQ0 (R-actinin-4), P26473 (ADP-ribosylation factor), P26437 (ADP-ribosylation factor),   Q7TNP1 (Basigin 2), Q6P6R2 (Dihydrolipoamide dehydrogenase),   P04797 (GAPDH), Q63081 (Protein disulfide isomerase), P29457 (47 kDa heat shock protein), Q9R1J8 (Leprecan), O88638 (Putative eps protein),   Q64375 (Synaptonemal complex)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:NDPK - Interactions involving proteins containing InterPro domain IPR001564, Nucleoside diphosphate kinase, core.	taxid:10116(rat-l6)|taxid:10116(Rattus norvegicus)	-	2006/02/15	2021/11/30	rogid:PbFY2lfrty8yw40Jq7ShR7xfuV410116	rogid:F1i32Asgu8HyhSLSqlkv8XZos2U10116	intact-crc:44F3A2176D02515F|rigid:9RVm0UBcqQF4k06RGKO89Bg16Q8	false	myc tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P19357	uniprotkb:P62425	intact:EBI-915426|uniprotkb:P97900|ensembl:ENSRNOP00000023256	intact:EBI-354184|uniprotkb:P11518	psi-mi:glut4_rat(display_long)|uniprotkb:Glucose transporter type 4, insulin-responsive(gene name synonym)|uniprotkb:Slc2a4(gene name)|psi-mi:Slc2a4(display_short)|uniprotkb:Glut4(gene name synonym)	psi-mi:rl7a_rat(display_long)|uniprotkb:Rpl7a(gene name)|psi-mi:Rpl7a(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Foster et al. (2006)	pubmed:16396496|mint:MINT-5218203	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-921030	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2711|refseq:NP_036883.1|refseq:XP_006246658.1|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007611"(learning or memory)|go:"GO:0007614"(short-term memory)|go:"GO:0007616"(long-term memory)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010021"(amylopectin biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031550"(positive regulation of brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044381"(glucose import in response to insulin stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046323"(glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0098694"(regulation of synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0098793"(presynapse)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002441("Glucose transporter, type 4 (GLUT4)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-189200|ensembl:ENSRNOG00000017226(gene)|ensembl:ENSRNOT00000023256(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)	interpro:IPR029064|rgd:1307586|refseq:NP_001107863.1|interpro:IPR001921(Ribosomal protein L7A)|interpro:IPR004038(Ribosomal protein L7Ae/L30e/S12e/Gadd45)|interpro:IPR018492|interpro:IPR004037(Ribosomal protein L7Ae)|go:"GO:0000470"(maturation of LSU-rRNA)|go:"GO:0022626"(cytosolic ribosome)|go:"GO:0042788"(polysomal ribosome)|go:"GO:0045202"(synapse)|go:"GO:1904401"(cellular response to Thyroid stimulating hormone)|go:"GO:0003723"(RNA binding)|go:"GO:0003735"(structural constituent of ribosome)|go:"GO:0005730"(nucleolus)|go:"GO:0005840"(ribosome)|go:"GO:0016020"(membrane)|go:"GO:0022625"(cytosolic large ribosomal subunit)	-	-	-	caution:"The participant EBI-349571(P68370) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919386(Q7TP47) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920972(Q5XIP9) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-916419(P11980) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919578(Q8R491) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920554(Q5U3Z7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920647(Q5U2X8) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920585(Q7TP24) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-779677(P05426) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-915744(P02454) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|agonist:Insulin was shown to increase or decrease GLUT4 protein interactions in specific cases.|comment:"Insulin decreased GLUT4 interactions with the following proteins: Q9ER30 (Sarcosin), P09527 (Rab-7), O88960 (N-ethylmaleimide sensitive), P09456 (PKA I regulatory subunit), P27881 (Hexokinase type II), P07872 (Acyl-coenzyme A oxidase), Q6DGF1 (Isocitrate dehydrogenase), Q9EQX9 (Ubiquitin-conjugating), Q63446 (Polyubiquitin), P24268 (Cathepsin D), Q91XW0 (Heat shock protein 86), Q5FVH0 (unknown), P58405 (Striatin 3), Q62667 (Major vault protein), Q66H50 (unknown), Q09167 (splicing factor), Q9JHU5 (Arfaptin 1)."|comment:"Insulin increased GLUT4 interaction with the following proteins:Q9Z1P2 (R-actinin-1), P45592 (Cofilin), Q9QXQ0 (R-actinin-4), P26473 (ADP-ribosylation factor), P26437 (ADP-ribosylation factor),   Q7TNP1 (Basigin 2), Q6P6R2 (Dihydrolipoamide dehydrogenase),   P04797 (GAPDH), Q63081 (Protein disulfide isomerase), P29457 (47 kDa heat shock protein), Q9R1J8 (Leprecan), O88638 (Putative eps protein),   Q64375 (Synaptonemal complex)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:NDPK - Interactions involving proteins containing InterPro domain IPR001564, Nucleoside diphosphate kinase, core.	taxid:10116(rat-l6)|taxid:10116(Rattus norvegicus)	-	2006/02/15	2021/11/30	rogid:PbFY2lfrty8yw40Jq7ShR7xfuV410116	rogid:shPtLmc+oabT/rSwho+tP1iJy4k10116	intact-crc:44F3A2176D02515F|rigid:9RVm0UBcqQF4k06RGKO89Bg16Q8	false	myc tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P19357	uniprotkb:P62332	intact:EBI-915426|uniprotkb:P97900|ensembl:ENSRNOP00000023256	intact:EBI-917930|uniprotkb:P26438|uniprotkb:Q5BKA5|ensembl:ENSRNOP00000006355	psi-mi:glut4_rat(display_long)|uniprotkb:Glucose transporter type 4, insulin-responsive(gene name synonym)|uniprotkb:Slc2a4(gene name)|psi-mi:Slc2a4(display_short)|uniprotkb:Glut4(gene name synonym)	psi-mi:arf6_rat(display_long)|uniprotkb:Arf6(gene name)|psi-mi:Arf6(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Foster et al. (2006)	pubmed:16396496|mint:MINT-5218203	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-921030	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2711|refseq:NP_036883.1|refseq:XP_006246658.1|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007611"(learning or memory)|go:"GO:0007614"(short-term memory)|go:"GO:0007616"(long-term memory)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010021"(amylopectin biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031550"(positive regulation of brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044381"(glucose import in response to insulin stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046323"(glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0098694"(regulation of synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0098793"(presynapse)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002441("Glucose transporter, type 4 (GLUT4)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-189200|ensembl:ENSRNOG00000017226(gene)|ensembl:ENSRNOT00000023256(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)	rgd:621279|refseq:NP_077066.1|ensembl:ENSRNOG00000004791(gene)|ensembl:ENSRNOT00000006355(transcript)|go:"GO:0001726"(ruffle)|go:"GO:0001889"(liver development)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005769"(early endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005938"(cell cortex)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0007399"(nervous system development)|go:"GO:0010975"(regulation of neuron projection development)|go:"GO:0016020"(membrane)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0019003"(GDP binding)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030139"(endocytic vesicle)|go:"GO:0030154"(cell differentiation)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0030866"(cortical actin cytoskeleton organization)|go:"GO:0031527"(filopodium membrane)|go:"GO:0031901"(early endosome membrane)|go:"GO:0031996"(thioesterase binding)|go:"GO:0032154"(cleavage furrow)|go:"GO:0032456"(endocytic recycling)|go:"GO:0033028"(myeloid cell apoptotic process)|go:"GO:0034394"(protein localization to cell surface)|go:"GO:0035020"(regulation of Rac protein signal transduction)|go:"GO:0036010"(protein localization to endosome)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048488"(synaptic vesicle endocytosis)|go:"GO:0050714"(positive regulation of protein secretion)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0051549"(positive regulation of keratinocyte migration)|go:"GO:0055037"(recycling endosome)|go:"GO:0055038"(recycling endosome membrane)|go:"GO:0060998"(regulation of dendritic spine development)|go:"GO:0090162"(establishment of epithelial cell polarity)|go:"GO:0090543"(Flemming body)|go:"GO:0097178"(ruffle assembly)|go:"GO:0097284"(hepatocyte apoptotic process)|go:"GO:0098793"(presynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099562"(maintenance of postsynaptic density structure)|go:"GO:0120183"(positive regulation of focal adhesion disassembly)|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|go:"GO:1905606"(regulation of presynapse assembly)|go:"GO:1990090"(cellular response to nerve growth factor stimulus)|go:"GO:2000009"(negative regulation of protein localization to cell surface)|go:"GO:2000171"(negative regulation of dendrite development)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR006689(ARF/SAR superfamily)|interpro:IPR027417|interpro:IPR041838|reactome:R-RNO-8854214|reactome:R-RNO-8856828|reactome:R-RNO-8875656	-	-	-	caution:"The participant EBI-349571(P68370) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919386(Q7TP47) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920972(Q5XIP9) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-916419(P11980) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919578(Q8R491) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920554(Q5U3Z7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920647(Q5U2X8) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920585(Q7TP24) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-779677(P05426) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-915744(P02454) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|agonist:Insulin was shown to increase or decrease GLUT4 protein interactions in specific cases.|comment:"Insulin decreased GLUT4 interactions with the following proteins: Q9ER30 (Sarcosin), P09527 (Rab-7), O88960 (N-ethylmaleimide sensitive), P09456 (PKA I regulatory subunit), P27881 (Hexokinase type II), P07872 (Acyl-coenzyme A oxidase), Q6DGF1 (Isocitrate dehydrogenase), Q9EQX9 (Ubiquitin-conjugating), Q63446 (Polyubiquitin), P24268 (Cathepsin D), Q91XW0 (Heat shock protein 86), Q5FVH0 (unknown), P58405 (Striatin 3), Q62667 (Major vault protein), Q66H50 (unknown), Q09167 (splicing factor), Q9JHU5 (Arfaptin 1)."|comment:"Insulin increased GLUT4 interaction with the following proteins:Q9Z1P2 (R-actinin-1), P45592 (Cofilin), Q9QXQ0 (R-actinin-4), P26473 (ADP-ribosylation factor), P26437 (ADP-ribosylation factor),   Q7TNP1 (Basigin 2), Q6P6R2 (Dihydrolipoamide dehydrogenase),   P04797 (GAPDH), Q63081 (Protein disulfide isomerase), P29457 (47 kDa heat shock protein), Q9R1J8 (Leprecan), O88638 (Putative eps protein),   Q64375 (Synaptonemal complex)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:NDPK - Interactions involving proteins containing InterPro domain IPR001564, Nucleoside diphosphate kinase, core.	taxid:10116(rat-l6)|taxid:10116(Rattus norvegicus)	-	2006/02/15	2021/11/30	rogid:PbFY2lfrty8yw40Jq7ShR7xfuV410116	rogid:c+9TIZ6WGhwZzmFUnkW20tPjlC810116	intact-crc:44F3A2176D02515F|rigid:9RVm0UBcqQF4k06RGKO89Bg16Q8	false	myc tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P19357	uniprotkb:P62282	intact:EBI-915426|uniprotkb:P97900|ensembl:ENSRNOP00000023256	intact:EBI-352498|uniprotkb:P04643|ensembl:ENSRNOP00000061250	psi-mi:glut4_rat(display_long)|uniprotkb:Glucose transporter type 4, insulin-responsive(gene name synonym)|uniprotkb:Slc2a4(gene name)|psi-mi:Slc2a4(display_short)|uniprotkb:Glut4(gene name synonym)	psi-mi:rs11_rat(display_long)|uniprotkb:Rps11(gene name)|psi-mi:Rps11(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Foster et al. (2006)	pubmed:16396496|mint:MINT-5218203	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-921030	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2711|refseq:NP_036883.1|refseq:XP_006246658.1|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007611"(learning or memory)|go:"GO:0007614"(short-term memory)|go:"GO:0007616"(long-term memory)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010021"(amylopectin biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031550"(positive regulation of brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044381"(glucose import in response to insulin stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046323"(glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0098694"(regulation of synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0098793"(presynapse)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002441("Glucose transporter, type 4 (GLUT4)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-189200|ensembl:ENSRNOG00000017226(gene)|ensembl:ENSRNOT00000023256(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)	rgd:621026|refseq:NP_112372.1|ensembl:ENSRNOG00000020595(gene)|ensembl:ENSRNOT00000066328(transcript)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0003735"(structural constituent of ribosome)|go:"GO:0006412"(translation)|go:"GO:0016020"(membrane)|go:"GO:0019843"(rRNA binding)|go:"GO:0022626"(cytosolic ribosome)|go:"GO:0022627"(cytosolic small ribosomal subunit)|interpro:IPR000266(Ribosomal protein S17)|interpro:IPR012340(Nucleic acid-binding, OB-fold)|interpro:IPR019979|interpro:IPR028333|interpro:IPR032440|mint:P62282|reactome:R-RNO-156827|reactome:R-RNO-1799339|reactome:R-RNO-6791226|reactome:R-RNO-72649|reactome:R-RNO-72689|reactome:R-RNO-72695|reactome:R-RNO-72702|reactome:R-RNO-72706|reactome:R-RNO-975956|reactome:R-RNO-975957	-	-	-	caution:"The participant EBI-349571(P68370) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919386(Q7TP47) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920972(Q5XIP9) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-916419(P11980) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919578(Q8R491) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920554(Q5U3Z7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920647(Q5U2X8) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920585(Q7TP24) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-779677(P05426) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-915744(P02454) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|agonist:Insulin was shown to increase or decrease GLUT4 protein interactions in specific cases.|comment:"Insulin decreased GLUT4 interactions with the following proteins: Q9ER30 (Sarcosin), P09527 (Rab-7), O88960 (N-ethylmaleimide sensitive), P09456 (PKA I regulatory subunit), P27881 (Hexokinase type II), P07872 (Acyl-coenzyme A oxidase), Q6DGF1 (Isocitrate dehydrogenase), Q9EQX9 (Ubiquitin-conjugating), Q63446 (Polyubiquitin), P24268 (Cathepsin D), Q91XW0 (Heat shock protein 86), Q5FVH0 (unknown), P58405 (Striatin 3), Q62667 (Major vault protein), Q66H50 (unknown), Q09167 (splicing factor), Q9JHU5 (Arfaptin 1)."|comment:"Insulin increased GLUT4 interaction with the following proteins:Q9Z1P2 (R-actinin-1), P45592 (Cofilin), Q9QXQ0 (R-actinin-4), P26473 (ADP-ribosylation factor), P26437 (ADP-ribosylation factor),   Q7TNP1 (Basigin 2), Q6P6R2 (Dihydrolipoamide dehydrogenase),   P04797 (GAPDH), Q63081 (Protein disulfide isomerase), P29457 (47 kDa heat shock protein), Q9R1J8 (Leprecan), O88638 (Putative eps protein),   Q64375 (Synaptonemal complex)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:NDPK - Interactions involving proteins containing InterPro domain IPR001564, Nucleoside diphosphate kinase, core.	taxid:10116(rat-l6)|taxid:10116(Rattus norvegicus)	-	2006/02/15	2021/11/30	rogid:PbFY2lfrty8yw40Jq7ShR7xfuV410116	rogid:0fqJjtWAuz31VTKt2mbteRoi8vA10116	intact-crc:44F3A2176D02515F|rigid:9RVm0UBcqQF4k06RGKO89Bg16Q8	false	myc tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P19357	uniprotkb:P62278	intact:EBI-915426|uniprotkb:P97900|ensembl:ENSRNOP00000023256	intact:EBI-351861|uniprotkb:P19116|uniprotkb:Q02546|uniprotkb:Q29200|ensembl:ENSRNOP00000036690	psi-mi:glut4_rat(display_long)|uniprotkb:Glucose transporter type 4, insulin-responsive(gene name synonym)|uniprotkb:Slc2a4(gene name)|psi-mi:Slc2a4(display_short)|uniprotkb:Glut4(gene name synonym)	psi-mi:rs13_rat(display_long)|uniprotkb:Rps13(gene name)|psi-mi:Rps13(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Foster et al. (2006)	pubmed:16396496|mint:MINT-5218203	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-921030	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2711|refseq:NP_036883.1|refseq:XP_006246658.1|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007611"(learning or memory)|go:"GO:0007614"(short-term memory)|go:"GO:0007616"(long-term memory)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010021"(amylopectin biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031550"(positive regulation of brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044381"(glucose import in response to insulin stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046323"(glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0098694"(regulation of synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0098793"(presynapse)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002441("Glucose transporter, type 4 (GLUT4)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-189200|ensembl:ENSRNOG00000017226(gene)|ensembl:ENSRNOT00000023256(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)	rgd:621027|refseq:NP_569116.1|refseq:XP_001053043.1|ensembl:ENSRNOG00000028021(gene)|ensembl:ENSRNOT00000034694(transcript)|go:"GO:0003729"(mRNA binding)|go:"GO:0003735"(structural constituent of ribosome)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0006412"(translation)|go:"GO:0014069"(postsynaptic density)|go:"GO:0022626"(cytosolic ribosome)|go:"GO:0022627"(cytosolic small ribosomal subunit)|go:"GO:0033119"(negative regulation of RNA splicing)|go:"GO:0045202"(synapse)|go:"GO:0048027"(mRNA 5'-UTR binding)|go:"GO:0070181"(small ribosomal subunit rRNA binding)|go:"GO:1990932"(5.8S rRNA binding)|interpro:IPR000589(Ribosomal protein S15)|interpro:IPR009068(S15/NS1, RNA-binding)|interpro:IPR012606(Ribosomal protein S13/S15, N-terminal)|interpro:IPR023029|mint:P62278|reactome:R-RNO-156827|reactome:R-RNO-1799339|reactome:R-RNO-6791226|reactome:R-RNO-72649|reactome:R-RNO-72689|reactome:R-RNO-72695|reactome:R-RNO-72702|reactome:R-RNO-72706|reactome:R-RNO-975956|reactome:R-RNO-975957|refseq:XP_003753737.1	-	-	-	caution:"The participant EBI-349571(P68370) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919386(Q7TP47) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920972(Q5XIP9) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-916419(P11980) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919578(Q8R491) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920554(Q5U3Z7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920647(Q5U2X8) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920585(Q7TP24) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-779677(P05426) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-915744(P02454) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|agonist:Insulin was shown to increase or decrease GLUT4 protein interactions in specific cases.|comment:"Insulin decreased GLUT4 interactions with the following proteins: Q9ER30 (Sarcosin), P09527 (Rab-7), O88960 (N-ethylmaleimide sensitive), P09456 (PKA I regulatory subunit), P27881 (Hexokinase type II), P07872 (Acyl-coenzyme A oxidase), Q6DGF1 (Isocitrate dehydrogenase), Q9EQX9 (Ubiquitin-conjugating), Q63446 (Polyubiquitin), P24268 (Cathepsin D), Q91XW0 (Heat shock protein 86), Q5FVH0 (unknown), P58405 (Striatin 3), Q62667 (Major vault protein), Q66H50 (unknown), Q09167 (splicing factor), Q9JHU5 (Arfaptin 1)."|comment:"Insulin increased GLUT4 interaction with the following proteins:Q9Z1P2 (R-actinin-1), P45592 (Cofilin), Q9QXQ0 (R-actinin-4), P26473 (ADP-ribosylation factor), P26437 (ADP-ribosylation factor),   Q7TNP1 (Basigin 2), Q6P6R2 (Dihydrolipoamide dehydrogenase),   P04797 (GAPDH), Q63081 (Protein disulfide isomerase), P29457 (47 kDa heat shock protein), Q9R1J8 (Leprecan), O88638 (Putative eps protein),   Q64375 (Synaptonemal complex)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:NDPK - Interactions involving proteins containing InterPro domain IPR001564, Nucleoside diphosphate kinase, core.	taxid:10116(rat-l6)|taxid:10116(Rattus norvegicus)	-	2006/02/15	2021/11/30	rogid:PbFY2lfrty8yw40Jq7ShR7xfuV410116	rogid:GmlWYkXKxX6YwpEtzNABb+ZcytI10116	intact-crc:44F3A2176D02515F|rigid:9RVm0UBcqQF4k06RGKO89Bg16Q8	false	myc tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P19357	uniprotkb:P62271	intact:EBI-915426|uniprotkb:P97900|ensembl:ENSRNOP00000023256	intact:EBI-352442|uniprotkb:A0JN05|uniprotkb:P25232|ensembl:ENSRNOP00000047371|ensembl:ENSRNOP00000075857	psi-mi:glut4_rat(display_long)|uniprotkb:Glucose transporter type 4, insulin-responsive(gene name synonym)|uniprotkb:Slc2a4(gene name)|psi-mi:Slc2a4(display_short)|uniprotkb:Glut4(gene name synonym)	psi-mi:rs18_rat(display_long)|uniprotkb:Rps18(gene name)|psi-mi:Rps18(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Foster et al. (2006)	pubmed:16396496|mint:MINT-5218203	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-921030	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2711|refseq:NP_036883.1|refseq:XP_006246658.1|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007611"(learning or memory)|go:"GO:0007614"(short-term memory)|go:"GO:0007616"(long-term memory)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010021"(amylopectin biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031550"(positive regulation of brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044381"(glucose import in response to insulin stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046323"(glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0098694"(regulation of synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0098793"(presynapse)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002441("Glucose transporter, type 4 (GLUT4)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-189200|ensembl:ENSRNOG00000017226(gene)|ensembl:ENSRNOT00000023256(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)	rgd:3595|refseq:NP_998722.1|refseq:XP_002724624.1|refseq:XP_002727879.1|ensembl:ENSRNOG00000028505(gene)|ensembl:ENSRNOG00000033152(gene)|ensembl:ENSRNOT00000046010(transcript)|ensembl:ENSRNOT00000092476(transcript)|go:"GO:0003735"(structural constituent of ribosome)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0006412"(translation)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015935"(small ribosomal subunit)|go:"GO:0019843"(rRNA binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0022626"(cytosolic ribosome)|go:"GO:0022627"(cytosolic small ribosomal subunit)|go:"GO:0045202"(synapse)|interpro:IPR001892(Ribosomal protein S13)|interpro:IPR010979(Ribosomal protein S13-like, H2TH)|interpro:IPR018269|interpro:IPR027437|reactome:R-RNO-156827|reactome:R-RNO-1799339|reactome:R-RNO-6791226|reactome:R-RNO-72649|reactome:R-RNO-72689|reactome:R-RNO-72695|reactome:R-RNO-72702|reactome:R-RNO-72706|reactome:R-RNO-975956|reactome:R-RNO-975957	-	-	-	caution:"The participant EBI-349571(P68370) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919386(Q7TP47) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920972(Q5XIP9) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-916419(P11980) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919578(Q8R491) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920554(Q5U3Z7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920647(Q5U2X8) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920585(Q7TP24) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-779677(P05426) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-915744(P02454) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|agonist:Insulin was shown to increase or decrease GLUT4 protein interactions in specific cases.|comment:"Insulin decreased GLUT4 interactions with the following proteins: Q9ER30 (Sarcosin), P09527 (Rab-7), O88960 (N-ethylmaleimide sensitive), P09456 (PKA I regulatory subunit), P27881 (Hexokinase type II), P07872 (Acyl-coenzyme A oxidase), Q6DGF1 (Isocitrate dehydrogenase), Q9EQX9 (Ubiquitin-conjugating), Q63446 (Polyubiquitin), P24268 (Cathepsin D), Q91XW0 (Heat shock protein 86), Q5FVH0 (unknown), P58405 (Striatin 3), Q62667 (Major vault protein), Q66H50 (unknown), Q09167 (splicing factor), Q9JHU5 (Arfaptin 1)."|comment:"Insulin increased GLUT4 interaction with the following proteins:Q9Z1P2 (R-actinin-1), P45592 (Cofilin), Q9QXQ0 (R-actinin-4), P26473 (ADP-ribosylation factor), P26437 (ADP-ribosylation factor),   Q7TNP1 (Basigin 2), Q6P6R2 (Dihydrolipoamide dehydrogenase),   P04797 (GAPDH), Q63081 (Protein disulfide isomerase), P29457 (47 kDa heat shock protein), Q9R1J8 (Leprecan), O88638 (Putative eps protein),   Q64375 (Synaptonemal complex)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:NDPK - Interactions involving proteins containing InterPro domain IPR001564, Nucleoside diphosphate kinase, core.	taxid:10116(rat-l6)|taxid:10116(Rattus norvegicus)	-	2006/02/15	2021/11/30	rogid:PbFY2lfrty8yw40Jq7ShR7xfuV410116	rogid:yOHgKM/BuvgGdqp1OEVPeuiABg810116	intact-crc:44F3A2176D02515F|rigid:9RVm0UBcqQF4k06RGKO89Bg16Q8	false	myc tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P19357	uniprotkb:P62268	intact:EBI-915426|uniprotkb:P97900|ensembl:ENSRNOP00000023256	intact:EBI-353083|ensembl:ENSRNOP00000022348|uniprotkb:P39028	psi-mi:glut4_rat(display_long)|uniprotkb:Glucose transporter type 4, insulin-responsive(gene name synonym)|uniprotkb:Slc2a4(gene name)|psi-mi:Slc2a4(display_short)|uniprotkb:Glut4(gene name synonym)	psi-mi:rs23_rat(display_long)|uniprotkb:Rps23(gene name)|psi-mi:Rps23(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Foster et al. (2006)	pubmed:16396496|mint:MINT-5218203	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-921030	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2711|refseq:NP_036883.1|refseq:XP_006246658.1|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007611"(learning or memory)|go:"GO:0007614"(short-term memory)|go:"GO:0007616"(long-term memory)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010021"(amylopectin biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031550"(positive regulation of brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044381"(glucose import in response to insulin stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046323"(glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0098694"(regulation of synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0098793"(presynapse)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002441("Glucose transporter, type 4 (GLUT4)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-189200|ensembl:ENSRNOG00000017226(gene)|ensembl:ENSRNOT00000023256(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)	interpro:IPR006032(Ribosomal protein S12/S23)|interpro:IPR005680(Ribosomal protein S23, eukaryotic/archaeal)|interpro:IPR012340(Nucleic acid-binding, OB-fold)|reactome:R-RNO-156827|reactome:R-RNO-1799339|reactome:R-RNO-6791226|reactome:R-RNO-72649|reactome:R-RNO-72689|reactome:R-RNO-72695|reactome:R-RNO-72702|reactome:R-RNO-72706|reactome:R-RNO-975956|reactome:R-RNO-975957|ensembl:ENSRNOT00000022348(transcript)|go:"GO:0002181"(cytoplasmic translation)|go:"GO:0003735"(structural constituent of ribosome)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0005840"(ribosome)|go:"GO:0006412"(translation)|go:"GO:0015935"(small ribosomal subunit)|go:"GO:0022626"(cytosolic ribosome)|go:"GO:0022627"(cytosolic small ribosomal subunit)|go:"GO:0034063"(stress granule assembly)|go:"GO:0042788"(polysomal ribosome)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045202"(synapse)|go:"GO:1990145"(maintenance of translational fidelity)|ensembl:ENSRNOG00000016580(gene)|rgd:621039|refseq:NP_511172.1	-	-	-	caution:"The participant EBI-349571(P68370) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919386(Q7TP47) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920972(Q5XIP9) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-916419(P11980) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919578(Q8R491) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920554(Q5U3Z7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920647(Q5U2X8) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920585(Q7TP24) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-779677(P05426) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-915744(P02454) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|agonist:Insulin was shown to increase or decrease GLUT4 protein interactions in specific cases.|comment:"Insulin decreased GLUT4 interactions with the following proteins: Q9ER30 (Sarcosin), P09527 (Rab-7), O88960 (N-ethylmaleimide sensitive), P09456 (PKA I regulatory subunit), P27881 (Hexokinase type II), P07872 (Acyl-coenzyme A oxidase), Q6DGF1 (Isocitrate dehydrogenase), Q9EQX9 (Ubiquitin-conjugating), Q63446 (Polyubiquitin), P24268 (Cathepsin D), Q91XW0 (Heat shock protein 86), Q5FVH0 (unknown), P58405 (Striatin 3), Q62667 (Major vault protein), Q66H50 (unknown), Q09167 (splicing factor), Q9JHU5 (Arfaptin 1)."|comment:"Insulin increased GLUT4 interaction with the following proteins:Q9Z1P2 (R-actinin-1), P45592 (Cofilin), Q9QXQ0 (R-actinin-4), P26473 (ADP-ribosylation factor), P26437 (ADP-ribosylation factor),   Q7TNP1 (Basigin 2), Q6P6R2 (Dihydrolipoamide dehydrogenase),   P04797 (GAPDH), Q63081 (Protein disulfide isomerase), P29457 (47 kDa heat shock protein), Q9R1J8 (Leprecan), O88638 (Putative eps protein),   Q64375 (Synaptonemal complex)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:NDPK - Interactions involving proteins containing InterPro domain IPR001564, Nucleoside diphosphate kinase, core.	taxid:10116(rat-l6)|taxid:10116(Rattus norvegicus)	-	2006/02/15	2021/11/30	rogid:PbFY2lfrty8yw40Jq7ShR7xfuV410116	rogid:MWZPvSL/G45ocaxA5AXKCkDQxNU10116	intact-crc:44F3A2176D02515F|rigid:9RVm0UBcqQF4k06RGKO89Bg16Q8	false	myc tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P19357	uniprotkb:P62260	intact:EBI-915426|uniprotkb:P97900|ensembl:ENSRNOP00000023256	intact:EBI-356462|uniprotkb:P29360|uniprotkb:P42655|uniprotkb:Q63631|ensembl:ENSRNOP00000007100	psi-mi:glut4_rat(display_long)|uniprotkb:Glucose transporter type 4, insulin-responsive(gene name synonym)|uniprotkb:Slc2a4(gene name)|psi-mi:Slc2a4(display_short)|uniprotkb:Glut4(gene name synonym)	psi-mi:1433e_rat(display_long)|uniprotkb:Ywhae(gene name)|psi-mi:Ywhae(display_short)|uniprotkb:Mitochondrial import stimulation factor L subunit(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Foster et al. (2006)	pubmed:16396496|mint:MINT-5218203	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-921030	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2711|refseq:NP_036883.1|refseq:XP_006246658.1|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007611"(learning or memory)|go:"GO:0007614"(short-term memory)|go:"GO:0007616"(long-term memory)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010021"(amylopectin biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031550"(positive regulation of brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044381"(glucose import in response to insulin stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046323"(glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0098694"(regulation of synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0098793"(presynapse)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002441("Glucose transporter, type 4 (GLUT4)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-189200|ensembl:ENSRNOG00000017226(gene)|ensembl:ENSRNOT00000023256(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)	rgd:62000|refseq:NP_113791.1|ensembl:ENSRNOG00000005290(gene)|ensembl:ENSRNOT00000007100(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001764"(neuron migration)|go:"GO:0005246"(calcium channel regulator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005871"(kinesin complex)|go:"GO:0005886"(plasma membrane)|go:"GO:0006605"(protein targeting)|go:"GO:0007165"(signal transduction)|go:"GO:0008426"(protein kinase C inhibitor activity)|go:"GO:0015459"(potassium channel regulator activity)|go:"GO:0019899"(enzyme binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0021766"(hippocampus development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030424"(axon)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0034504"(protein localization to nucleus)|go:"GO:0034605"(cellular response to heat)|go:"GO:0035308"(negative regulation of protein dephosphorylation)|go:"GO:0042470"(melanosome)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0046827"(positive regulation of protein export from nucleus)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0050815"(phosphoserine residue binding)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0051480"(regulation of cytosolic calcium ion concentration)|go:"GO:0060306"(regulation of membrane repolarization)|go:"GO:0090724"(central region of growth cone)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099072"(regulation of postsynaptic membrane neurotransmitter receptor levels)|go:"GO:1901016"(regulation of potassium ion transmembrane transporter activity)|go:"GO:1901020"(negative regulation of calcium ion transmembrane transporter activity)|go:"GO:1902309"(negative regulation of peptidyl-serine dephosphorylation)|go:"GO:1905913"(negative regulation of calcium ion export across plasma membrane)|interpro:IPR000308(14-3-3 protein)|interpro:IPR023409|interpro:IPR023410|interpro:IPR036815|mint:P62260|reactome:R-RNO-111447|reactome:R-RNO-2028269|reactome:R-RNO-205025|reactome:R-RNO-2565942|reactome:R-RNO-3371453|reactome:R-RNO-3371511|reactome:R-RNO-380259|reactome:R-RNO-380270|reactome:R-RNO-380284|reactome:R-RNO-380320|reactome:R-RNO-5620912|reactome:R-RNO-5625740|reactome:R-RNO-5628897|reactome:R-RNO-75035|reactome:R-RNO-8854518|reactome:R-RNO-8876198|dip:DIP-37260N	-	-	-	caution:"The participant EBI-349571(P68370) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919386(Q7TP47) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920972(Q5XIP9) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-916419(P11980) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919578(Q8R491) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920554(Q5U3Z7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920647(Q5U2X8) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920585(Q7TP24) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-779677(P05426) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-915744(P02454) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|agonist:Insulin was shown to increase or decrease GLUT4 protein interactions in specific cases.|comment:"Insulin decreased GLUT4 interactions with the following proteins: Q9ER30 (Sarcosin), P09527 (Rab-7), O88960 (N-ethylmaleimide sensitive), P09456 (PKA I regulatory subunit), P27881 (Hexokinase type II), P07872 (Acyl-coenzyme A oxidase), Q6DGF1 (Isocitrate dehydrogenase), Q9EQX9 (Ubiquitin-conjugating), Q63446 (Polyubiquitin), P24268 (Cathepsin D), Q91XW0 (Heat shock protein 86), Q5FVH0 (unknown), P58405 (Striatin 3), Q62667 (Major vault protein), Q66H50 (unknown), Q09167 (splicing factor), Q9JHU5 (Arfaptin 1)."|comment:"Insulin increased GLUT4 interaction with the following proteins:Q9Z1P2 (R-actinin-1), P45592 (Cofilin), Q9QXQ0 (R-actinin-4), P26473 (ADP-ribosylation factor), P26437 (ADP-ribosylation factor),   Q7TNP1 (Basigin 2), Q6P6R2 (Dihydrolipoamide dehydrogenase),   P04797 (GAPDH), Q63081 (Protein disulfide isomerase), P29457 (47 kDa heat shock protein), Q9R1J8 (Leprecan), O88638 (Putative eps protein),   Q64375 (Synaptonemal complex)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:NDPK - Interactions involving proteins containing InterPro domain IPR001564, Nucleoside diphosphate kinase, core.	taxid:10116(rat-l6)|taxid:10116(Rattus norvegicus)	-	2006/02/15	2021/11/30	rogid:PbFY2lfrty8yw40Jq7ShR7xfuV410116	rogid:mnuAjdnQZbMFojll2PnV3xFklXQ10116	intact-crc:44F3A2176D02515F|rigid:9RVm0UBcqQF4k06RGKO89Bg16Q8	false	myc tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P19357	uniprotkb:P62250	intact:EBI-915426|uniprotkb:P97900|ensembl:ENSRNOP00000023256	intact:EBI-352489|uniprotkb:P17008|ensembl:ENSRNOP00000026576	psi-mi:glut4_rat(display_long)|uniprotkb:Glucose transporter type 4, insulin-responsive(gene name synonym)|uniprotkb:Slc2a4(gene name)|psi-mi:Slc2a4(display_short)|uniprotkb:Glut4(gene name synonym)	psi-mi:rs16_rat(display_long)|uniprotkb:Rps16(gene name)|psi-mi:Rps16(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Foster et al. (2006)	pubmed:16396496|mint:MINT-5218203	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-921030	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2711|refseq:NP_036883.1|refseq:XP_006246658.1|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007611"(learning or memory)|go:"GO:0007614"(short-term memory)|go:"GO:0007616"(long-term memory)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010021"(amylopectin biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031550"(positive regulation of brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044381"(glucose import in response to insulin stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046323"(glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0098694"(regulation of synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0098793"(presynapse)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002441("Glucose transporter, type 4 (GLUT4)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-189200|ensembl:ENSRNOG00000017226(gene)|ensembl:ENSRNOT00000023256(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)	rgd:621031|refseq:NP_001162617.1|ensembl:ENSRNOG00000019578(gene)|ensembl:ENSRNOT00000026576(transcript)|go:"GO:0000462"("maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)")|go:"GO:0003723"(RNA binding)|go:"GO:0003735"(structural constituent of ribosome)|go:"GO:0006364"(rRNA processing)|go:"GO:0006412"(translation)|go:"GO:0015935"(small ribosomal subunit)|go:"GO:0022626"(cytosolic ribosome)|go:"GO:0022627"(cytosolic small ribosomal subunit)|go:"GO:0042274"(ribosomal small subunit biogenesis)|go:"GO:0097421"(liver regeneration)|go:"GO:1990830"(cellular response to leukemia inhibitory factor)|interpro:IPR000754(Ribosomal protein S9)|interpro:IPR014721(Ribosomal protein S5 domain 2-type fold)|interpro:IPR020568|interpro:IPR020574|mint:P62250|reactome:R-RNO-156827|reactome:R-RNO-1799339|reactome:R-RNO-6791226|reactome:R-RNO-72649|reactome:R-RNO-72689|reactome:R-RNO-72695|reactome:R-RNO-72702|reactome:R-RNO-72706|reactome:R-RNO-975956|reactome:R-RNO-975957	-	-	-	caution:"The participant EBI-349571(P68370) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919386(Q7TP47) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920972(Q5XIP9) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-916419(P11980) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919578(Q8R491) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920554(Q5U3Z7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920647(Q5U2X8) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920585(Q7TP24) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-779677(P05426) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-915744(P02454) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|agonist:Insulin was shown to increase or decrease GLUT4 protein interactions in specific cases.|comment:"Insulin decreased GLUT4 interactions with the following proteins: Q9ER30 (Sarcosin), P09527 (Rab-7), O88960 (N-ethylmaleimide sensitive), P09456 (PKA I regulatory subunit), P27881 (Hexokinase type II), P07872 (Acyl-coenzyme A oxidase), Q6DGF1 (Isocitrate dehydrogenase), Q9EQX9 (Ubiquitin-conjugating), Q63446 (Polyubiquitin), P24268 (Cathepsin D), Q91XW0 (Heat shock protein 86), Q5FVH0 (unknown), P58405 (Striatin 3), Q62667 (Major vault protein), Q66H50 (unknown), Q09167 (splicing factor), Q9JHU5 (Arfaptin 1)."|comment:"Insulin increased GLUT4 interaction with the following proteins:Q9Z1P2 (R-actinin-1), P45592 (Cofilin), Q9QXQ0 (R-actinin-4), P26473 (ADP-ribosylation factor), P26437 (ADP-ribosylation factor),   Q7TNP1 (Basigin 2), Q6P6R2 (Dihydrolipoamide dehydrogenase),   P04797 (GAPDH), Q63081 (Protein disulfide isomerase), P29457 (47 kDa heat shock protein), Q9R1J8 (Leprecan), O88638 (Putative eps protein),   Q64375 (Synaptonemal complex)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:NDPK - Interactions involving proteins containing InterPro domain IPR001564, Nucleoside diphosphate kinase, core.	taxid:10116(rat-l6)|taxid:10116(Rattus norvegicus)	-	2006/02/15	2021/11/30	rogid:PbFY2lfrty8yw40Jq7ShR7xfuV410116	rogid:OrKriR6HsATLaO+drdUa2w3Gpd010116	intact-crc:44F3A2176D02515F|rigid:9RVm0UBcqQF4k06RGKO89Bg16Q8	false	myc tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P19357	uniprotkb:P62243	intact:EBI-915426|uniprotkb:P97900|ensembl:ENSRNOP00000023256	intact:EBI-351802|uniprotkb:P09058|ensembl:ENSRNOP00000074753	psi-mi:glut4_rat(display_long)|uniprotkb:Glucose transporter type 4, insulin-responsive(gene name synonym)|uniprotkb:Slc2a4(gene name)|psi-mi:Slc2a4(display_short)|uniprotkb:Glut4(gene name synonym)	psi-mi:rs8_rat(display_long)|uniprotkb:Rps8(gene name)|psi-mi:Rps8(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Foster et al. (2006)	pubmed:16396496|mint:MINT-5218203	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-921030	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2711|refseq:NP_036883.1|refseq:XP_006246658.1|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007611"(learning or memory)|go:"GO:0007614"(short-term memory)|go:"GO:0007616"(long-term memory)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010021"(amylopectin biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031550"(positive regulation of brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044381"(glucose import in response to insulin stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046323"(glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0098694"(regulation of synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0098793"(presynapse)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002441("Glucose transporter, type 4 (GLUT4)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-189200|ensembl:ENSRNOG00000017226(gene)|ensembl:ENSRNOT00000023256(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)	rgd:61910|refseq:NP_113894.1|ensembl:ENSRNOG00000054626(gene)|ensembl:ENSRNOT00000081747(transcript)|go:"GO:0000462"("maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)")|go:"GO:0003735"(structural constituent of ribosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0006412"(translation)|go:"GO:0016020"(membrane)|go:"GO:0022626"(cytosolic ribosome)|go:"GO:0022627"(cytosolic small ribosomal subunit)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR001047(Ribosomal protein S8e)|interpro:IPR018283|interpro:IPR022309|interpro:IPR042563|reactome:R-RNO-156827|reactome:R-RNO-1799339|reactome:R-RNO-6791226|reactome:R-RNO-72649|reactome:R-RNO-72689|reactome:R-RNO-72695|reactome:R-RNO-72702|reactome:R-RNO-72706|reactome:R-RNO-975956|reactome:R-RNO-975957	-	-	-	caution:"The participant EBI-349571(P68370) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919386(Q7TP47) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920972(Q5XIP9) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-916419(P11980) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919578(Q8R491) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920554(Q5U3Z7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920647(Q5U2X8) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920585(Q7TP24) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-779677(P05426) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-915744(P02454) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|agonist:Insulin was shown to increase or decrease GLUT4 protein interactions in specific cases.|comment:"Insulin decreased GLUT4 interactions with the following proteins: Q9ER30 (Sarcosin), P09527 (Rab-7), O88960 (N-ethylmaleimide sensitive), P09456 (PKA I regulatory subunit), P27881 (Hexokinase type II), P07872 (Acyl-coenzyme A oxidase), Q6DGF1 (Isocitrate dehydrogenase), Q9EQX9 (Ubiquitin-conjugating), Q63446 (Polyubiquitin), P24268 (Cathepsin D), Q91XW0 (Heat shock protein 86), Q5FVH0 (unknown), P58405 (Striatin 3), Q62667 (Major vault protein), Q66H50 (unknown), Q09167 (splicing factor), Q9JHU5 (Arfaptin 1)."|comment:"Insulin increased GLUT4 interaction with the following proteins:Q9Z1P2 (R-actinin-1), P45592 (Cofilin), Q9QXQ0 (R-actinin-4), P26473 (ADP-ribosylation factor), P26437 (ADP-ribosylation factor),   Q7TNP1 (Basigin 2), Q6P6R2 (Dihydrolipoamide dehydrogenase),   P04797 (GAPDH), Q63081 (Protein disulfide isomerase), P29457 (47 kDa heat shock protein), Q9R1J8 (Leprecan), O88638 (Putative eps protein),   Q64375 (Synaptonemal complex)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:NDPK - Interactions involving proteins containing InterPro domain IPR001564, Nucleoside diphosphate kinase, core.	taxid:10116(rat-l6)|taxid:10116(Rattus norvegicus)	-	2006/02/15	2021/11/30	rogid:PbFY2lfrty8yw40Jq7ShR7xfuV410116	rogid:3rpCBdQyRWR+TCKnupbnCp30jKE10116	intact-crc:44F3A2176D02515F|rigid:9RVm0UBcqQF4k06RGKO89Bg16Q8	false	myc tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P19357	uniprotkb:P62198	intact:EBI-915426|uniprotkb:P97900|ensembl:ENSRNOP00000023256	intact:EBI-357761|uniprotkb:O35051|uniprotkb:P47210|uniprotkb:P52916|uniprotkb:P52915|ensembl:ENSRNOP00000013997	psi-mi:glut4_rat(display_long)|uniprotkb:Glucose transporter type 4, insulin-responsive(gene name synonym)|uniprotkb:Slc2a4(gene name)|psi-mi:Slc2a4(display_short)|uniprotkb:Glut4(gene name synonym)	psi-mi:prs8_rat(display_long)|uniprotkb:Psmc5(gene name)|psi-mi:Psmc5(display_short)|uniprotkb:Sug1(gene name synonym)|uniprotkb:Proteasome 26S subunit ATPase 5(gene name synonym)|uniprotkb:Proteasome subunit p45(gene name synonym)|uniprotkb:p45/SUG(gene name synonym)|uniprotkb:Thyroid hormone receptor-interacting protein 1(gene name synonym)|uniprotkb:26S proteasome AAA-ATPase subunit RPT6(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Foster et al. (2006)	pubmed:16396496|mint:MINT-5218203	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-921030	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2711|refseq:NP_036883.1|refseq:XP_006246658.1|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007611"(learning or memory)|go:"GO:0007614"(short-term memory)|go:"GO:0007616"(long-term memory)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010021"(amylopectin biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031550"(positive regulation of brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044381"(glucose import in response to insulin stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046323"(glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0098694"(regulation of synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0098793"(presynapse)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002441("Glucose transporter, type 4 (GLUT4)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-189200|ensembl:ENSRNOG00000017226(gene)|ensembl:ENSRNOT00000023256(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)	rgd:708376|refseq:NP_112411.1|ensembl:ENSRNOG00000010038(gene)|ensembl:ENSRNOT00000013997(transcript)|go:"GO:0000502"(proteasome complex)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005838"(proteasome regulatory particle)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008540"(proteasome regulatory particle, base subcomplex)|go:"GO:0016234"(inclusion body)|go:"GO:0017025"(TBP-class protein binding)|go:"GO:0022624"(proteasome accessory complex)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031531"(thyrotropin-releasing hormone receptor binding)|go:"GO:0031595"(nuclear proteasome complex)|go:"GO:0031597"(cytosolic proteasome complex)|go:"GO:0036402"(proteasome-activating activity)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045899"(positive regulation of RNA polymerase II transcription preinitiation complex assembly)|reactome:R-RNO-5358346|reactome:R-RNO-5607761|reactome:R-RNO-5610780|reactome:R-RNO-5610785|reactome:R-RNO-5632684|reactome:R-RNO-5658442|reactome:R-RNO-5668541|reactome:R-RNO-5676590|reactome:R-RNO-5687128|reactome:R-RNO-5689603|reactome:R-RNO-5689880|reactome:R-RNO-68827|reactome:R-RNO-68949|reactome:R-RNO-69017|reactome:R-RNO-69481|reactome:R-RNO-69601|reactome:R-RNO-75815|reactome:R-RNO-8852276|reactome:R-RNO-8854050|reactome:R-RNO-8932339|reactome:R-RNO-4641258|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0090261"(positive regulation of inclusion body assembly)|go:"GO:0098794"(postsynapse)|go:"GO:0099576"(regulation of protein catabolic process at postsynapse, modulating synaptic transmission)|go:"GO:0140296"(general transcription initiation factor binding)|go:"GO:0140297"(DNA-binding transcription factor binding)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR003959(AAA ATPase, core)|interpro:IPR003960(AAA ATPase, conserved site)|interpro:IPR005937(26S proteasome subunit P45)|interpro:IPR027417|interpro:IPR032501|interpro:IPR041569|rcsb pdb:6EPC|rcsb pdb:6EPD|rcsb pdb:6EPE|rcsb pdb:6EPF|reactome:R-RNO-1169091|reactome:R-RNO-1234176|reactome:R-RNO-1236978|reactome:R-RNO-174084|reactome:R-RNO-174154|reactome:R-RNO-174178|reactome:R-RNO-174184|reactome:R-RNO-187577|reactome:R-RNO-195253|reactome:R-RNO-2467813|reactome:R-RNO-349425|reactome:R-RNO-350562|reactome:R-RNO-382556|reactome:R-RNO-450408|reactome:R-RNO-4608870|reactome:R-RNO-4641257|reactome:R-RNO-8939236|reactome:R-RNO-8941858|reactome:R-RNO-8951664|reactome:R-RNO-983168|reactome:R-RNO-8948751	-	-	-	caution:"The participant EBI-349571(P68370) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919386(Q7TP47) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920972(Q5XIP9) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-916419(P11980) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919578(Q8R491) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920554(Q5U3Z7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920647(Q5U2X8) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920585(Q7TP24) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-779677(P05426) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-915744(P02454) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|agonist:Insulin was shown to increase or decrease GLUT4 protein interactions in specific cases.|comment:"Insulin decreased GLUT4 interactions with the following proteins: Q9ER30 (Sarcosin), P09527 (Rab-7), O88960 (N-ethylmaleimide sensitive), P09456 (PKA I regulatory subunit), P27881 (Hexokinase type II), P07872 (Acyl-coenzyme A oxidase), Q6DGF1 (Isocitrate dehydrogenase), Q9EQX9 (Ubiquitin-conjugating), Q63446 (Polyubiquitin), P24268 (Cathepsin D), Q91XW0 (Heat shock protein 86), Q5FVH0 (unknown), P58405 (Striatin 3), Q62667 (Major vault protein), Q66H50 (unknown), Q09167 (splicing factor), Q9JHU5 (Arfaptin 1)."|comment:"Insulin increased GLUT4 interaction with the following proteins:Q9Z1P2 (R-actinin-1), P45592 (Cofilin), Q9QXQ0 (R-actinin-4), P26473 (ADP-ribosylation factor), P26437 (ADP-ribosylation factor),   Q7TNP1 (Basigin 2), Q6P6R2 (Dihydrolipoamide dehydrogenase),   P04797 (GAPDH), Q63081 (Protein disulfide isomerase), P29457 (47 kDa heat shock protein), Q9R1J8 (Leprecan), O88638 (Putative eps protein),   Q64375 (Synaptonemal complex)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:NDPK - Interactions involving proteins containing InterPro domain IPR001564, Nucleoside diphosphate kinase, core.	taxid:10116(rat-l6)|taxid:10116(Rattus norvegicus)	-	2006/02/15	2021/11/30	rogid:PbFY2lfrty8yw40Jq7ShR7xfuV410116	rogid:zgUTOX/O4m86U/Nf+pnT7u0m0gY10116	intact-crc:44F3A2176D02515F|rigid:9RVm0UBcqQF4k06RGKO89Bg16Q8	false	myc tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P19357	uniprotkb:P62193	intact:EBI-915426|uniprotkb:P97900|ensembl:ENSRNOP00000023256	intact:EBI-357586|uniprotkb:P49014|uniprotkb:Q96AZ3|uniprotkb:Q03527|ensembl:ENSRNOP00000005329	psi-mi:glut4_rat(display_long)|uniprotkb:Glucose transporter type 4, insulin-responsive(gene name synonym)|uniprotkb:Slc2a4(gene name)|psi-mi:Slc2a4(display_short)|uniprotkb:Glut4(gene name synonym)	psi-mi:prs4_rat(display_long)|uniprotkb:Psmc1(gene name)|psi-mi:Psmc1(display_short)|uniprotkb:26S proteasome AAA-ATPase subunit RPT2(gene name synonym)|uniprotkb:Proteasome 26S subunit ATPase 1(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Foster et al. (2006)	pubmed:16396496|mint:MINT-5218203	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-921030	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2711|refseq:NP_036883.1|refseq:XP_006246658.1|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007611"(learning or memory)|go:"GO:0007614"(short-term memory)|go:"GO:0007616"(long-term memory)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010021"(amylopectin biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031550"(positive regulation of brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044381"(glucose import in response to insulin stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046323"(glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0098694"(regulation of synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0098793"(presynapse)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002441("Glucose transporter, type 4 (GLUT4)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-189200|ensembl:ENSRNOG00000017226(gene)|ensembl:ENSRNOT00000023256(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)	ensembl:ENSRNOG00000003951(gene)|ensembl:ENSRNOT00000005329(transcript)|go:"GO:0000502"(proteasome complex)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005838"(proteasome regulatory particle)|go:"GO:0008540"(proteasome regulatory particle, base subcomplex)|go:"GO:0016020"(membrane)|go:"GO:0017025"(TBP-class protein binding)|go:"GO:0022624"(proteasome accessory complex)|go:"GO:0030163"(protein catabolic process)|go:"GO:0036402"(proteasome-activating activity)|go:"GO:1901215"(negative regulation of neuron death)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR003959(AAA ATPase, core)|interpro:IPR003960(AAA ATPase, conserved site)|interpro:IPR005937(26S proteasome subunit P45)|interpro:IPR027417|interpro:IPR032501|interpro:IPR035244|interpro:IPR041569|rcsb pdb:6EPC|rcsb pdb:6EPD|rcsb pdb:6EPE|rcsb pdb:6EPF|reactome:R-RNO-1169091|reactome:R-RNO-1234176|reactome:R-RNO-1236978|reactome:R-RNO-174084|reactome:R-RNO-174154|reactome:R-RNO-174178|reactome:R-RNO-174184|reactome:R-RNO-187577|reactome:R-RNO-195253|reactome:R-RNO-2467813|reactome:R-RNO-349425|reactome:R-RNO-350562|reactome:R-RNO-382556|reactome:R-RNO-450408|reactome:R-RNO-4608870|reactome:R-RNO-4641257|reactome:R-RNO-4641258|reactome:R-RNO-532668|reactome:R-RNO-5358346|reactome:R-RNO-5607761|reactome:R-RNO-5610780|reactome:R-RNO-5610785|reactome:R-RNO-5632684|reactome:R-RNO-5658442|reactome:R-RNO-5668541|reactome:R-RNO-5676590|reactome:R-RNO-5687128|reactome:R-RNO-5689603|reactome:R-RNO-5689880|reactome:R-RNO-68827|reactome:R-RNO-68949|reactome:R-RNO-69017|reactome:R-RNO-69481|reactome:R-RNO-69601|reactome:R-RNO-75815|reactome:R-RNO-8852276|reactome:R-RNO-8854050|reactome:R-RNO-8932339|reactome:R-RNO-8939236|reactome:R-RNO-8941858|reactome:R-RNO-8948751|reactome:R-RNO-8951664|reactome:R-RNO-983168|rgd:621097|refseq:NP_476464.1	-	-	-	caution:"The participant EBI-349571(P68370) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919386(Q7TP47) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920972(Q5XIP9) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-916419(P11980) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919578(Q8R491) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920554(Q5U3Z7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920647(Q5U2X8) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920585(Q7TP24) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-779677(P05426) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-915744(P02454) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|agonist:Insulin was shown to increase or decrease GLUT4 protein interactions in specific cases.|comment:"Insulin decreased GLUT4 interactions with the following proteins: Q9ER30 (Sarcosin), P09527 (Rab-7), O88960 (N-ethylmaleimide sensitive), P09456 (PKA I regulatory subunit), P27881 (Hexokinase type II), P07872 (Acyl-coenzyme A oxidase), Q6DGF1 (Isocitrate dehydrogenase), Q9EQX9 (Ubiquitin-conjugating), Q63446 (Polyubiquitin), P24268 (Cathepsin D), Q91XW0 (Heat shock protein 86), Q5FVH0 (unknown), P58405 (Striatin 3), Q62667 (Major vault protein), Q66H50 (unknown), Q09167 (splicing factor), Q9JHU5 (Arfaptin 1)."|comment:"Insulin increased GLUT4 interaction with the following proteins:Q9Z1P2 (R-actinin-1), P45592 (Cofilin), Q9QXQ0 (R-actinin-4), P26473 (ADP-ribosylation factor), P26437 (ADP-ribosylation factor),   Q7TNP1 (Basigin 2), Q6P6R2 (Dihydrolipoamide dehydrogenase),   P04797 (GAPDH), Q63081 (Protein disulfide isomerase), P29457 (47 kDa heat shock protein), Q9R1J8 (Leprecan), O88638 (Putative eps protein),   Q64375 (Synaptonemal complex)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:NDPK - Interactions involving proteins containing InterPro domain IPR001564, Nucleoside diphosphate kinase, core.	taxid:10116(rat-l6)|taxid:10116(Rattus norvegicus)	-	2006/02/15	2021/11/30	rogid:PbFY2lfrty8yw40Jq7ShR7xfuV410116	rogid:oGEtU7Cv0qversbD3WQgAo5H9pM10116	intact-crc:44F3A2176D02515F|rigid:9RVm0UBcqQF4k06RGKO89Bg16Q8	false	myc tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P19357	uniprotkb:P62142	intact:EBI-915426|uniprotkb:P97900|ensembl:ENSRNOP00000023256	intact:EBI-352326|ensembl:ENSRNOP00000006190|uniprotkb:P37140	psi-mi:glut4_rat(display_long)|uniprotkb:Glucose transporter type 4, insulin-responsive(gene name synonym)|uniprotkb:Slc2a4(gene name)|psi-mi:Slc2a4(display_short)|uniprotkb:Glut4(gene name synonym)	psi-mi:pp1b_rat(display_long)|uniprotkb:Ppp1cb(gene name)|psi-mi:Ppp1cb(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Foster et al. (2006)	pubmed:16396496|mint:MINT-5218203	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-921030	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2711|refseq:NP_036883.1|refseq:XP_006246658.1|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007611"(learning or memory)|go:"GO:0007614"(short-term memory)|go:"GO:0007616"(long-term memory)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010021"(amylopectin biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031550"(positive regulation of brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044381"(glucose import in response to insulin stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046323"(glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0098694"(regulation of synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0098793"(presynapse)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002441("Glucose transporter, type 4 (GLUT4)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-189200|ensembl:ENSRNOG00000017226(gene)|ensembl:ENSRNOT00000023256(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)	ensembl:ENSRNOG00000004612(gene)|ensembl:ENSRNOT00000006190(transcript)|go:"GO:0000164"(protein phosphatase type 1 complex)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0004721"(phosphoprotein phosphatase activity)|go:"GO:0004722"(protein serine/threonine phosphatase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005977"(glycogen metabolic process)|go:"GO:0005979"(regulation of glycogen biosynthetic process)|go:"GO:0005981"(regulation of glycogen catabolic process)|rgd:3376|refseq:NP_037197.1|go:"GO:0019901"(protein kinase binding)|go:"GO:0030155"(regulation of cell adhesion)|go:"GO:0017018"(myosin phosphatase activity)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0007049"(cell cycle)|go:"GO:0016791"(phosphatase activity)|go:"GO:0042587"(glycogen granule)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0043153"(entrainment of circadian clock by photoperiod)|go:"GO:0046872"(metal ion binding)|go:"GO:0050115"(myosin-light-chain-phosphatase activity)|go:"GO:0051301"(cell division)|go:"GO:0072357"(PTW/PP1 phosphatase complex)|go:"GO:0106306"|go:"GO:0106307"|interpro:IPR004843(Metallophosphoesterase)|interpro:IPR006186("Serine/threonine-specific protein phosphatase and bis(5-nucleosyl)-tetraphosphatase")|interpro:IPR029052|interpro:IPR031675|reactome:R-RNO-2565942|reactome:R-RNO-5625740|reactome:R-RNO-5627123|reactome:R-RNO-5673000|go:"GO:0032922"(circadian regulation of gene expression)|refseq:XP_008762727.1	-	-	-	caution:"The participant EBI-349571(P68370) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919386(Q7TP47) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920972(Q5XIP9) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-916419(P11980) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919578(Q8R491) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920554(Q5U3Z7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920647(Q5U2X8) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920585(Q7TP24) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-779677(P05426) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-915744(P02454) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|agonist:Insulin was shown to increase or decrease GLUT4 protein interactions in specific cases.|comment:"Insulin decreased GLUT4 interactions with the following proteins: Q9ER30 (Sarcosin), P09527 (Rab-7), O88960 (N-ethylmaleimide sensitive), P09456 (PKA I regulatory subunit), P27881 (Hexokinase type II), P07872 (Acyl-coenzyme A oxidase), Q6DGF1 (Isocitrate dehydrogenase), Q9EQX9 (Ubiquitin-conjugating), Q63446 (Polyubiquitin), P24268 (Cathepsin D), Q91XW0 (Heat shock protein 86), Q5FVH0 (unknown), P58405 (Striatin 3), Q62667 (Major vault protein), Q66H50 (unknown), Q09167 (splicing factor), Q9JHU5 (Arfaptin 1)."|comment:"Insulin increased GLUT4 interaction with the following proteins:Q9Z1P2 (R-actinin-1), P45592 (Cofilin), Q9QXQ0 (R-actinin-4), P26473 (ADP-ribosylation factor), P26437 (ADP-ribosylation factor),   Q7TNP1 (Basigin 2), Q6P6R2 (Dihydrolipoamide dehydrogenase),   P04797 (GAPDH), Q63081 (Protein disulfide isomerase), P29457 (47 kDa heat shock protein), Q9R1J8 (Leprecan), O88638 (Putative eps protein),   Q64375 (Synaptonemal complex)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:NDPK - Interactions involving proteins containing InterPro domain IPR001564, Nucleoside diphosphate kinase, core.	taxid:10116(rat-l6)|taxid:10116(Rattus norvegicus)	-	2006/02/15	2021/11/30	rogid:PbFY2lfrty8yw40Jq7ShR7xfuV410116	rogid:VtNJVyimeiEuRDDWtGswTqoSOH810116	intact-crc:44F3A2176D02515F|rigid:9RVm0UBcqQF4k06RGKO89Bg16Q8	false	myc tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P19357	uniprotkb:P62138	intact:EBI-915426|uniprotkb:P97900|ensembl:ENSRNOP00000023256	intact:EBI-357231|ensembl:ENSRNOP00000025282|uniprotkb:P08129|uniprotkb:P22802|uniprotkb:P20653	psi-mi:glut4_rat(display_long)|uniprotkb:Glucose transporter type 4, insulin-responsive(gene name synonym)|uniprotkb:Slc2a4(gene name)|psi-mi:Slc2a4(display_short)|uniprotkb:Glut4(gene name synonym)	psi-mi:pp1a_rat(display_long)|uniprotkb:Ppp1ca(gene name)|psi-mi:Ppp1ca(display_short)|uniprotkb:Ppp1a(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Foster et al. (2006)	pubmed:16396496|mint:MINT-5218203	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-921030	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2711|refseq:NP_036883.1|refseq:XP_006246658.1|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007611"(learning or memory)|go:"GO:0007614"(short-term memory)|go:"GO:0007616"(long-term memory)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010021"(amylopectin biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031550"(positive regulation of brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044381"(glucose import in response to insulin stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046323"(glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0098694"(regulation of synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0098793"(presynapse)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002441("Glucose transporter, type 4 (GLUT4)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-189200|ensembl:ENSRNOG00000017226(gene)|ensembl:ENSRNOT00000023256(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)	ensembl:ENSRNOT00000025282(transcript)|go:"GO:0000164"(protein phosphatase type 1 complex)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0004721"(phosphoprotein phosphatase activity)|go:"GO:0004722"(protein serine/threonine phosphatase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005912"(adherens junction)|go:"GO:0005977"(glycogen metabolic process)|go:"GO:0005979"(regulation of glycogen biosynthetic process)|ensembl:ENSRNOG00000018708(gene)|go:"GO:0005981"(regulation of glycogen catabolic process)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0007049"(cell cycle)|go:"GO:0008157"(protein phosphatase 1 binding)|go:"GO:0010288"(response to lead ion)|go:"GO:0016311"(dephosphorylation)|go:"GO:0016791"(phosphatase activity)|go:"GO:0030324"(lung development)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0042587"(glycogen granule)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0043005"(neuron projection)|go:"GO:0043021"(ribonucleoprotein complex binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043153"(entrainment of circadian clock by photoperiod)|go:"GO:0043197"(dendritic spine)|go:"GO:0043204"(perikaryon)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0048754"(branching morphogenesis of an epithelial tube)|go:"GO:0051301"(cell division)|go:"GO:0072357"(PTW/PP1 phosphatase complex)|go:"GO:0098641"(cadherin binding involved in cell-cell adhesion)|go:"GO:0098793"(presynapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0106306"|go:"GO:0106307"|go:"GO:2001241"(positive regulation of extrinsic apoptotic signaling pathway in absence of ligand)|interpro:IPR004843(Metallophosphoesterase)|interpro:IPR029052|interpro:IPR031675|interpro:IPR037979|mint:P62138|reactome:R-RNO-180024|interpro:IPR006186("Serine/threonine-specific protein phosphatase and bis(5-nucleosyl)-tetraphosphatase")|rgd:3375|refseq:NP_113715.1	-	-	-	caution:"The participant EBI-349571(P68370) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919386(Q7TP47) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920972(Q5XIP9) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-916419(P11980) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919578(Q8R491) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920554(Q5U3Z7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920647(Q5U2X8) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920585(Q7TP24) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-779677(P05426) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-915744(P02454) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|agonist:Insulin was shown to increase or decrease GLUT4 protein interactions in specific cases.|comment:"Insulin decreased GLUT4 interactions with the following proteins: Q9ER30 (Sarcosin), P09527 (Rab-7), O88960 (N-ethylmaleimide sensitive), P09456 (PKA I regulatory subunit), P27881 (Hexokinase type II), P07872 (Acyl-coenzyme A oxidase), Q6DGF1 (Isocitrate dehydrogenase), Q9EQX9 (Ubiquitin-conjugating), Q63446 (Polyubiquitin), P24268 (Cathepsin D), Q91XW0 (Heat shock protein 86), Q5FVH0 (unknown), P58405 (Striatin 3), Q62667 (Major vault protein), Q66H50 (unknown), Q09167 (splicing factor), Q9JHU5 (Arfaptin 1)."|comment:"Insulin increased GLUT4 interaction with the following proteins:Q9Z1P2 (R-actinin-1), P45592 (Cofilin), Q9QXQ0 (R-actinin-4), P26473 (ADP-ribosylation factor), P26437 (ADP-ribosylation factor),   Q7TNP1 (Basigin 2), Q6P6R2 (Dihydrolipoamide dehydrogenase),   P04797 (GAPDH), Q63081 (Protein disulfide isomerase), P29457 (47 kDa heat shock protein), Q9R1J8 (Leprecan), O88638 (Putative eps protein),   Q64375 (Synaptonemal complex)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:NDPK - Interactions involving proteins containing InterPro domain IPR001564, Nucleoside diphosphate kinase, core.	taxid:10116(rat-l6)|taxid:10116(Rattus norvegicus)	-	2006/02/15	2021/11/30	rogid:PbFY2lfrty8yw40Jq7ShR7xfuV410116	rogid:IMypaKng+5AECbCd3N72pgzUlxQ10116	intact-crc:44F3A2176D02515F|rigid:9RVm0UBcqQF4k06RGKO89Bg16Q8	false	myc tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P19357	uniprotkb:P62083	intact:EBI-915426|uniprotkb:P97900|ensembl:ENSRNOP00000023256	intact:EBI-354370|uniprotkb:P24818|uniprotkb:P23821|ensembl:ENSRNOP00000011333|ensembl:ENSRNOP00000075995	psi-mi:glut4_rat(display_long)|uniprotkb:Glucose transporter type 4, insulin-responsive(gene name synonym)|uniprotkb:Slc2a4(gene name)|psi-mi:Slc2a4(display_short)|uniprotkb:Glut4(gene name synonym)	psi-mi:rs7_rat(display_long)|uniprotkb:Rps7(gene name)|psi-mi:Rps7(display_short)|uniprotkb:S8(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Foster et al. (2006)	pubmed:16396496|mint:MINT-5218203	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-921030	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2711|refseq:NP_036883.1|refseq:XP_006246658.1|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007611"(learning or memory)|go:"GO:0007614"(short-term memory)|go:"GO:0007616"(long-term memory)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010021"(amylopectin biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031550"(positive regulation of brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044381"(glucose import in response to insulin stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046323"(glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0098694"(regulation of synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0098793"(presynapse)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002441("Glucose transporter, type 4 (GLUT4)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-189200|ensembl:ENSRNOG00000017226(gene)|ensembl:ENSRNOT00000023256(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)	refseq:NP_113758.2|refseq:XP_002726666.2|refseq:XP_002729622.2|rgd:61907|ensembl:ENSRNOG00000008551(gene)|ensembl:ENSRNOT00000011333(transcript)|ensembl:ENSRNOT00000092867(transcript)|go:"GO:0001843"(neural tube closure)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0003735"(structural constituent of ribosome)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0006364"(rRNA processing)|go:"GO:0008266"("poly(U) RNA binding")|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0019901"(protein kinase binding)|go:"GO:0022626"(cytosolic ribosome)|go:"GO:0022627"(cytosolic small ribosomal subunit)|go:"GO:0030154"(cell differentiation)|go:"GO:0032040"(small-subunit processome)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042274"(ribosomal small subunit biogenesis)|go:"GO:0045202"(synapse)|go:"GO:0048027"(mRNA 5'-UTR binding)|go:"GO:0050821"(protein stabilization)|go:"GO:1902255"(positive regulation of intrinsic apoptotic signaling pathway by p53 class mediator)|go:"GO:1904667"(negative regulation of ubiquitin protein ligase activity)|go:"GO:1990904"(ribonucleoprotein complex)|go:"GO:1990948"(ubiquitin ligase inhibitor activity)|go:"GO:2000059"(negative regulation of ubiquitin-dependent protein catabolic process)|interpro:IPR000554(Ribosomal protein S7e)|mint:P62083|reactome:R-RNO-156827|reactome:R-RNO-1799339|reactome:R-RNO-6791226|reactome:R-RNO-72649|reactome:R-RNO-72689|reactome:R-RNO-72695|reactome:R-RNO-72702|reactome:R-RNO-72706|reactome:R-RNO-975956|reactome:R-RNO-975957|go:"GO:0006412"(translation)	-	-	-	caution:"The participant EBI-349571(P68370) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919386(Q7TP47) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920972(Q5XIP9) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-916419(P11980) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919578(Q8R491) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920554(Q5U3Z7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920647(Q5U2X8) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920585(Q7TP24) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-779677(P05426) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-915744(P02454) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|agonist:Insulin was shown to increase or decrease GLUT4 protein interactions in specific cases.|comment:"Insulin decreased GLUT4 interactions with the following proteins: Q9ER30 (Sarcosin), P09527 (Rab-7), O88960 (N-ethylmaleimide sensitive), P09456 (PKA I regulatory subunit), P27881 (Hexokinase type II), P07872 (Acyl-coenzyme A oxidase), Q6DGF1 (Isocitrate dehydrogenase), Q9EQX9 (Ubiquitin-conjugating), Q63446 (Polyubiquitin), P24268 (Cathepsin D), Q91XW0 (Heat shock protein 86), Q5FVH0 (unknown), P58405 (Striatin 3), Q62667 (Major vault protein), Q66H50 (unknown), Q09167 (splicing factor), Q9JHU5 (Arfaptin 1)."|comment:"Insulin increased GLUT4 interaction with the following proteins:Q9Z1P2 (R-actinin-1), P45592 (Cofilin), Q9QXQ0 (R-actinin-4), P26473 (ADP-ribosylation factor), P26437 (ADP-ribosylation factor),   Q7TNP1 (Basigin 2), Q6P6R2 (Dihydrolipoamide dehydrogenase),   P04797 (GAPDH), Q63081 (Protein disulfide isomerase), P29457 (47 kDa heat shock protein), Q9R1J8 (Leprecan), O88638 (Putative eps protein),   Q64375 (Synaptonemal complex)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:NDPK - Interactions involving proteins containing InterPro domain IPR001564, Nucleoside diphosphate kinase, core.	taxid:10116(rat-l6)|taxid:10116(Rattus norvegicus)	-	2006/02/15	2021/11/30	rogid:PbFY2lfrty8yw40Jq7ShR7xfuV410116	rogid:l4aG6I34lmzYhNapbdv2CAAwRwg10116	intact-crc:44F3A2176D02515F|rigid:9RVm0UBcqQF4k06RGKO89Bg16Q8	false	myc tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P19357	uniprotkb:P61983	intact:EBI-915426|uniprotkb:P97900|ensembl:ENSRNOP00000023256	intact:EBI-359821|uniprotkb:A0JPM0|uniprotkb:O70457|uniprotkb:Q9UDP2|uniprotkb:P35214|uniprotkb:Q9UN99|ensembl:ENSRNOP00000001954|ensembl:ENSRNOP00000069671	psi-mi:glut4_rat(display_long)|uniprotkb:Glucose transporter type 4, insulin-responsive(gene name synonym)|uniprotkb:Slc2a4(gene name)|psi-mi:Slc2a4(display_short)|uniprotkb:Glut4(gene name synonym)	psi-mi:1433g_rat(display_long)|uniprotkb:Ywhag(gene name)|psi-mi:Ywhag(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Foster et al. (2006)	pubmed:16396496|mint:MINT-5218203	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-921030	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2711|refseq:NP_036883.1|refseq:XP_006246658.1|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007611"(learning or memory)|go:"GO:0007614"(short-term memory)|go:"GO:0007616"(long-term memory)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010021"(amylopectin biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031550"(positive regulation of brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044381"(glucose import in response to insulin stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046323"(glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0098694"(regulation of synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0098793"(presynapse)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002441("Glucose transporter, type 4 (GLUT4)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-189200|ensembl:ENSRNOG00000017226(gene)|ensembl:ENSRNOT00000023256(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)	rgd:62002|refseq:NP_062249.1|ensembl:ENSRNOG00000001436(gene)|ensembl:ENSRNOT00000001954(transcript)|ensembl:ENSRNOT00000084730(transcript)|go:"GO:0003779"(actin binding)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005159"(insulin-like growth factor receptor binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0006605"(protein targeting)|go:"GO:0007165"(signal transduction)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030234"(enzyme regulator activity)|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0031982"(vesicle)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042802"(identical protein binding)|go:"GO:0045202"(synapse)|go:"GO:0045664"(regulation of neuron differentiation)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0098793"(presynapse)|interpro:IPR000308(14-3-3 protein)|interpro:IPR023409|interpro:IPR023410|interpro:IPR036815|mint:P61983|reactome:R-RNO-111447|reactome:R-RNO-2565942|reactome:R-RNO-380259|reactome:R-RNO-380270|reactome:R-RNO-380284|reactome:R-RNO-380320|reactome:R-RNO-5620912|reactome:R-RNO-5625740|reactome:R-RNO-5628897|reactome:R-RNO-75035|reactome:R-RNO-8854518|reactome:R-RNO-9614399|refseq:XP_006249246.2	-	-	-	caution:"The participant EBI-349571(P68370) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919386(Q7TP47) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920972(Q5XIP9) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-916419(P11980) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919578(Q8R491) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920554(Q5U3Z7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920647(Q5U2X8) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920585(Q7TP24) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-779677(P05426) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-915744(P02454) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|agonist:Insulin was shown to increase or decrease GLUT4 protein interactions in specific cases.|comment:"Insulin decreased GLUT4 interactions with the following proteins: Q9ER30 (Sarcosin), P09527 (Rab-7), O88960 (N-ethylmaleimide sensitive), P09456 (PKA I regulatory subunit), P27881 (Hexokinase type II), P07872 (Acyl-coenzyme A oxidase), Q6DGF1 (Isocitrate dehydrogenase), Q9EQX9 (Ubiquitin-conjugating), Q63446 (Polyubiquitin), P24268 (Cathepsin D), Q91XW0 (Heat shock protein 86), Q5FVH0 (unknown), P58405 (Striatin 3), Q62667 (Major vault protein), Q66H50 (unknown), Q09167 (splicing factor), Q9JHU5 (Arfaptin 1)."|comment:"Insulin increased GLUT4 interaction with the following proteins:Q9Z1P2 (R-actinin-1), P45592 (Cofilin), Q9QXQ0 (R-actinin-4), P26473 (ADP-ribosylation factor), P26437 (ADP-ribosylation factor),   Q7TNP1 (Basigin 2), Q6P6R2 (Dihydrolipoamide dehydrogenase),   P04797 (GAPDH), Q63081 (Protein disulfide isomerase), P29457 (47 kDa heat shock protein), Q9R1J8 (Leprecan), O88638 (Putative eps protein),   Q64375 (Synaptonemal complex)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:NDPK - Interactions involving proteins containing InterPro domain IPR001564, Nucleoside diphosphate kinase, core.	taxid:10116(rat-l6)|taxid:10116(Rattus norvegicus)	-	2006/02/15	2021/11/30	rogid:PbFY2lfrty8yw40Jq7ShR7xfuV410116	rogid:u1cd71h0RPgTOEMrQVhOelsxWnM10116	intact-crc:44F3A2176D02515F|rigid:9RVm0UBcqQF4k06RGKO89Bg16Q8	false	myc tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P19357	uniprotkb:P61980	intact:EBI-915426|uniprotkb:P97900|ensembl:ENSRNOP00000023256	intact:EBI-299761|ensembl:ENSRNOP00000025915|uniprotkb:Q07244|uniprotkb:Q15671|uniprotkb:Q60577|uniprotkb:Q922Y7|uniprotkb:Q96J62	psi-mi:glut4_rat(display_long)|uniprotkb:Glucose transporter type 4, insulin-responsive(gene name synonym)|uniprotkb:Slc2a4(gene name)|psi-mi:Slc2a4(display_short)|uniprotkb:Glut4(gene name synonym)	psi-mi:hnrpk_rat(display_long)|uniprotkb:Hnrnpk(gene name)|psi-mi:Hnrnpk(display_short)|uniprotkb:Hnrpk(gene name synonym)|uniprotkb:dC stretch-binding protein(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Foster et al. (2006)	pubmed:16396496|mint:MINT-5218203	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-921030	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2711|refseq:NP_036883.1|refseq:XP_006246658.1|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007611"(learning or memory)|go:"GO:0007614"(short-term memory)|go:"GO:0007616"(long-term memory)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010021"(amylopectin biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031550"(positive regulation of brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044381"(glucose import in response to insulin stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046323"(glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0098694"(regulation of synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0098793"(presynapse)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002441("Glucose transporter, type 4 (GLUT4)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-189200|ensembl:ENSRNOG00000017226(gene)|ensembl:ENSRNOT00000023256(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)	ensembl:ENSRNOG00000019113(gene)|ensembl:ENSRNOT00000025916(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000987"(cis-regulatory region sequence-specific DNA binding)|go:"GO:0001541"(ovarian follicle development)|go:"GO:0001822"(kidney development)|go:"GO:0001889"(liver development)|go:"GO:0002102"(podosome)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005521"(lamin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0005938"(cell cortex)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006397"(mRNA processing)|go:"GO:0006953"(acute-phase response)|go:"GO:0007417"(central nervous system development)|go:"GO:0007422"(peripheral nervous system development)|go:"GO:0007568"(aging)|go:"GO:0008380"(RNA splicing)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0010988"(regulation of low-density lipoprotein particle clearance)|go:"GO:0014069"(postsynaptic density)|go:"GO:0014823"(response to activity)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0021549"(cerebellum development)|go:"GO:0021766"(hippocampus development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030324"(lung development)|go:"GO:0030628"(pre-mRNA 3'-splice site binding)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0000785"(chromatin)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0032993"(protein-DNA complex)|go:"GO:0033120"(positive regulation of RNA splicing)|go:"GO:0042802"(identical protein binding)|go:"GO:0042805"(actinin binding)|go:"GO:0043010"(camera-type eye development)|go:"GO:0043021"(ribonucleoprotein complex binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043197"(dendritic spine)|go:"GO:0043679"(axon terminus)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048024"(regulation of mRNA splicing, via spliceosome)|go:"GO:0048025"(negative regulation of mRNA splicing, via spliceosome)|go:"GO:0048260"(positive regulation of receptor-mediated endocytosis)|go:"GO:0048538"(thymus development)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0051117"(ATPase binding)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0071013"(catalytic step 2 spliceosome)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071333"(cellular response to glucose stimulus)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0090129"(positive regulation of synapse maturation)|go:"GO:0098794"(postsynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099175"(regulation of postsynapse organization)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1902074"(response to salt)|go:"GO:1902165"(regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator)|go:"GO:1903861"(positive regulation of dendrite extension)|go:"GO:1904322"(cellular response to forskolin)|go:"GO:1905599"(positive regulation of low-density lipoprotein receptor activity)|go:"GO:1990715"(mRNA CDS binding)|go:"GO:1990829"(C-rich single-stranded DNA binding)|go:"GO:2000010"(positive regulation of protein localization to cell surface)|go:"GO:2000173"(negative regulation of branching morphogenesis of a nerve)|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR012987(ROK, N-terminal)|interpro:IPR033090|interpro:IPR036612|mint:P61980|reactome:R-RNO-4570464|reactome:R-RNO-72163|go:"GO:0072752"(cellular response to rapamycin)|rgd:71058|refseq:NP_476482.1|refseq:XP_006253616.1	-	-	-	caution:"The participant EBI-349571(P68370) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919386(Q7TP47) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920972(Q5XIP9) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-916419(P11980) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919578(Q8R491) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920554(Q5U3Z7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920647(Q5U2X8) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920585(Q7TP24) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-779677(P05426) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-915744(P02454) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|agonist:Insulin was shown to increase or decrease GLUT4 protein interactions in specific cases.|comment:"Insulin decreased GLUT4 interactions with the following proteins: Q9ER30 (Sarcosin), P09527 (Rab-7), O88960 (N-ethylmaleimide sensitive), P09456 (PKA I regulatory subunit), P27881 (Hexokinase type II), P07872 (Acyl-coenzyme A oxidase), Q6DGF1 (Isocitrate dehydrogenase), Q9EQX9 (Ubiquitin-conjugating), Q63446 (Polyubiquitin), P24268 (Cathepsin D), Q91XW0 (Heat shock protein 86), Q5FVH0 (unknown), P58405 (Striatin 3), Q62667 (Major vault protein), Q66H50 (unknown), Q09167 (splicing factor), Q9JHU5 (Arfaptin 1)."|comment:"Insulin increased GLUT4 interaction with the following proteins:Q9Z1P2 (R-actinin-1), P45592 (Cofilin), Q9QXQ0 (R-actinin-4), P26473 (ADP-ribosylation factor), P26437 (ADP-ribosylation factor),   Q7TNP1 (Basigin 2), Q6P6R2 (Dihydrolipoamide dehydrogenase),   P04797 (GAPDH), Q63081 (Protein disulfide isomerase), P29457 (47 kDa heat shock protein), Q9R1J8 (Leprecan), O88638 (Putative eps protein),   Q64375 (Synaptonemal complex)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:NDPK - Interactions involving proteins containing InterPro domain IPR001564, Nucleoside diphosphate kinase, core.	taxid:10116(rat-l6)|taxid:10116(Rattus norvegicus)	-	2006/02/15	2021/11/30	rogid:PbFY2lfrty8yw40Jq7ShR7xfuV410116	rogid:YZQD5JJkHPUMtZ4XUA9fQkNfXzc10116	intact-crc:44F3A2176D02515F|rigid:9RVm0UBcqQF4k06RGKO89Bg16Q8	false	myc tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P19357	uniprotkb:P61805	intact:EBI-915426|uniprotkb:P97900|ensembl:ENSRNOP00000023256	intact:EBI-917918|uniprotkb:O08552|uniprotkb:O70364|uniprotkb:P46966|uniprotkb:P46968|uniprotkb:Q96GB7|ensembl:ENSRNOP00000012233	psi-mi:glut4_rat(display_long)|uniprotkb:Glucose transporter type 4, insulin-responsive(gene name synonym)|uniprotkb:Slc2a4(gene name)|psi-mi:Slc2a4(display_short)|uniprotkb:Glut4(gene name synonym)	psi-mi:dad1_rat(display_long)|uniprotkb:Defender against cell death 1(gene name synonym)|uniprotkb:Dad1(gene name)|psi-mi:Dad1(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Foster et al. (2006)	pubmed:16396496|mint:MINT-5218203	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-921030	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2711|refseq:NP_036883.1|refseq:XP_006246658.1|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007611"(learning or memory)|go:"GO:0007614"(short-term memory)|go:"GO:0007616"(long-term memory)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010021"(amylopectin biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031550"(positive regulation of brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044381"(glucose import in response to insulin stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046323"(glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0098694"(regulation of synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0098793"(presynapse)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002441("Glucose transporter, type 4 (GLUT4)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-189200|ensembl:ENSRNOG00000017226(gene)|ensembl:ENSRNOT00000023256(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)	rgd:621028|refseq:NP_620265.1|ensembl:ENSRNOG00000009090(gene)|ensembl:ENSRNOT00000012233(transcript)|go:"GO:0001824"(blastocyst development)|go:"GO:0006486"(protein glycosylation)|go:"GO:0006487"(protein N-linked glycosylation)|go:"GO:0006915"(apoptotic process)|go:"GO:0007584"(response to nutrient)|go:"GO:0008047"(enzyme activator activity)|go:"GO:0008250"(oligosaccharyltransferase complex)|go:"GO:0016021"(integral component of membrane)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0042493"|go:"GO:0043066"(negative regulation of apoptotic process)|interpro:IPR003038(Defender against death DAD protein)|mint:P61805	-	-	-	caution:"The participant EBI-349571(P68370) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919386(Q7TP47) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920972(Q5XIP9) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-916419(P11980) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919578(Q8R491) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920554(Q5U3Z7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920647(Q5U2X8) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920585(Q7TP24) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-779677(P05426) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-915744(P02454) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|agonist:Insulin was shown to increase or decrease GLUT4 protein interactions in specific cases.|comment:"Insulin decreased GLUT4 interactions with the following proteins: Q9ER30 (Sarcosin), P09527 (Rab-7), O88960 (N-ethylmaleimide sensitive), P09456 (PKA I regulatory subunit), P27881 (Hexokinase type II), P07872 (Acyl-coenzyme A oxidase), Q6DGF1 (Isocitrate dehydrogenase), Q9EQX9 (Ubiquitin-conjugating), Q63446 (Polyubiquitin), P24268 (Cathepsin D), Q91XW0 (Heat shock protein 86), Q5FVH0 (unknown), P58405 (Striatin 3), Q62667 (Major vault protein), Q66H50 (unknown), Q09167 (splicing factor), Q9JHU5 (Arfaptin 1)."|comment:"Insulin increased GLUT4 interaction with the following proteins:Q9Z1P2 (R-actinin-1), P45592 (Cofilin), Q9QXQ0 (R-actinin-4), P26473 (ADP-ribosylation factor), P26437 (ADP-ribosylation factor),   Q7TNP1 (Basigin 2), Q6P6R2 (Dihydrolipoamide dehydrogenase),   P04797 (GAPDH), Q63081 (Protein disulfide isomerase), P29457 (47 kDa heat shock protein), Q9R1J8 (Leprecan), O88638 (Putative eps protein),   Q64375 (Synaptonemal complex)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:NDPK - Interactions involving proteins containing InterPro domain IPR001564, Nucleoside diphosphate kinase, core.	taxid:10116(rat-l6)|taxid:10116(Rattus norvegicus)	-	2006/02/15	2021/11/30	rogid:PbFY2lfrty8yw40Jq7ShR7xfuV410116	rogid:F7W13/LSSkZUPGLSXoXTfb3i4nY10116	intact-crc:44F3A2176D02515F|rigid:9RVm0UBcqQF4k06RGKO89Bg16Q8	false	myc tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P19357	uniprotkb:P61751	intact:EBI-915426|uniprotkb:P97900|ensembl:ENSRNOP00000023256	intact:EBI-917907|uniprotkb:P36403|ensembl:ENSRNOP00000017692	psi-mi:glut4_rat(display_long)|uniprotkb:Glucose transporter type 4, insulin-responsive(gene name synonym)|uniprotkb:Slc2a4(gene name)|psi-mi:Slc2a4(display_short)|uniprotkb:Glut4(gene name synonym)	psi-mi:arf4_rat(display_long)|uniprotkb:Arf4(gene name)|psi-mi:Arf4(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Foster et al. (2006)	pubmed:16396496|mint:MINT-5218203	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-921030	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2711|refseq:NP_036883.1|refseq:XP_006246658.1|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007611"(learning or memory)|go:"GO:0007614"(short-term memory)|go:"GO:0007616"(long-term memory)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010021"(amylopectin biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031550"(positive regulation of brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044381"(glucose import in response to insulin stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046323"(glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0098694"(regulation of synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0098793"(presynapse)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002441("Glucose transporter, type 4 (GLUT4)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-189200|ensembl:ENSRNOG00000017226(gene)|ensembl:ENSRNOT00000023256(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)	rgd:621275|refseq:NP_077065.1|ensembl:ENSRNOG00000012623(gene)|ensembl:ENSRNOT00000017692(transcript)|go:"GO:0003924"(GTPase activity)|go:"GO:0005154"(epidermal growth factor receptor binding)|go:"GO:0005525"(GTP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006471"(protein ADP-ribosylation)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006890"(retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007420"(brain development)|go:"GO:0007612"(learning)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0016477"(cell migration)|go:"GO:0031584"(activation of phospholipase D activity)|go:"GO:0032587"(ruffle membrane)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043197"(dendritic spine)|go:"GO:0045176"(apical protein localization)|go:"GO:0045197"(establishment or maintenance of epithelial cell apical/basal polarity)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048678"(response to axon injury)|go:"GO:0050807"(regulation of synapse organization)|go:"GO:0060996"(dendritic spine development)|go:"GO:0061512"(protein localization to cilium)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099175"(regulation of postsynapse organization)|go:"GO:2000377"(regulation of reactive oxygen species metabolic process)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR006689(ARF/SAR superfamily)|interpro:IPR027417|mint:P61751|reactome:R-RNO-5620916|reactome:R-RNO-6807878|reactome:R-RNO-6811434	-	-	-	caution:"The participant EBI-349571(P68370) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919386(Q7TP47) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920972(Q5XIP9) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-916419(P11980) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919578(Q8R491) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920554(Q5U3Z7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920647(Q5U2X8) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920585(Q7TP24) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-779677(P05426) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-915744(P02454) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|agonist:Insulin was shown to increase or decrease GLUT4 protein interactions in specific cases.|comment:"Insulin decreased GLUT4 interactions with the following proteins: Q9ER30 (Sarcosin), P09527 (Rab-7), O88960 (N-ethylmaleimide sensitive), P09456 (PKA I regulatory subunit), P27881 (Hexokinase type II), P07872 (Acyl-coenzyme A oxidase), Q6DGF1 (Isocitrate dehydrogenase), Q9EQX9 (Ubiquitin-conjugating), Q63446 (Polyubiquitin), P24268 (Cathepsin D), Q91XW0 (Heat shock protein 86), Q5FVH0 (unknown), P58405 (Striatin 3), Q62667 (Major vault protein), Q66H50 (unknown), Q09167 (splicing factor), Q9JHU5 (Arfaptin 1)."|comment:"Insulin increased GLUT4 interaction with the following proteins:Q9Z1P2 (R-actinin-1), P45592 (Cofilin), Q9QXQ0 (R-actinin-4), P26473 (ADP-ribosylation factor), P26437 (ADP-ribosylation factor),   Q7TNP1 (Basigin 2), Q6P6R2 (Dihydrolipoamide dehydrogenase),   P04797 (GAPDH), Q63081 (Protein disulfide isomerase), P29457 (47 kDa heat shock protein), Q9R1J8 (Leprecan), O88638 (Putative eps protein),   Q64375 (Synaptonemal complex)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:NDPK - Interactions involving proteins containing InterPro domain IPR001564, Nucleoside diphosphate kinase, core.	taxid:10116(rat-l6)|taxid:10116(Rattus norvegicus)	-	2006/02/15	2021/11/30	rogid:PbFY2lfrty8yw40Jq7ShR7xfuV410116	rogid:UQ8GuyD6go1ZCYpUU69uTevxoVo10116	intact-crc:44F3A2176D02515F|rigid:9RVm0UBcqQF4k06RGKO89Bg16Q8	false	myc tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P19357	uniprotkb:P61621	intact:EBI-915426|uniprotkb:P97900|ensembl:ENSRNOP00000023256	intact:EBI-358926|uniprotkb:P57726|uniprotkb:P38378|uniprotkb:Q505I3|intact:EBI-11702605|ensembl:ENSRNOP00000018455	psi-mi:glut4_rat(display_long)|uniprotkb:Glucose transporter type 4, insulin-responsive(gene name synonym)|uniprotkb:Slc2a4(gene name)|psi-mi:Slc2a4(display_short)|uniprotkb:Glut4(gene name synonym)	psi-mi:s61a1_rat(display_long)|uniprotkb:Sec61a1(gene name)|psi-mi:Sec61a1(display_short)|uniprotkb:Sec61a(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Foster et al. (2006)	pubmed:16396496|mint:MINT-5218203	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-921030	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2711|refseq:NP_036883.1|refseq:XP_006246658.1|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007611"(learning or memory)|go:"GO:0007614"(short-term memory)|go:"GO:0007616"(long-term memory)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010021"(amylopectin biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031550"(positive regulation of brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044381"(glucose import in response to insulin stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046323"(glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0098694"(regulation of synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0098793"(presynapse)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002441("Glucose transporter, type 4 (GLUT4)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-189200|ensembl:ENSRNOG00000017226(gene)|ensembl:ENSRNOT00000023256(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)	rgd:68321|refseq:NP_954865.1|ensembl:ENSRNOG00000013743(gene)|ensembl:ENSRNOT00000018454(transcript)|go:"GO:0005048"(signal sequence binding)|go:"GO:0005262"(calcium channel activity)|go:"GO:0005784"(Sec61 translocon complex)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0006613"(cotranslational protein targeting to membrane)|go:"GO:0006614"(SRP-dependent cotranslational protein targeting to membrane)|go:"GO:0006616"(SRP-dependent cotranslational protein targeting to membrane, translocation)|go:"GO:0006620"(posttranslational protein targeting to endoplasmic reticulum membrane)|go:"GO:0007029"(endoplasmic reticulum organization)|go:"GO:0008320"(protein transmembrane transporter activity)|go:"GO:0016020"(membrane)|go:"GO:0022857"(transmembrane transporter activity)|go:"GO:0030176"(integral component of endoplasmic reticulum membrane)|go:"GO:0031204"(posttranslational protein targeting to membrane, translocation)|go:"GO:0034341"(response to interferon-gamma)|go:"GO:0039019"(pronephric nephron development)|go:"GO:0043022"(ribosome binding)|go:"GO:0045048"(protein insertion into ER membrane)|interpro:IPR002208(SecY protein)|interpro:IPR019561|interpro:IPR023201|interpro:IPR030659	-	-	-	caution:"The participant EBI-349571(P68370) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919386(Q7TP47) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920972(Q5XIP9) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-916419(P11980) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919578(Q8R491) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920554(Q5U3Z7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920647(Q5U2X8) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920585(Q7TP24) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-779677(P05426) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-915744(P02454) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|agonist:Insulin was shown to increase or decrease GLUT4 protein interactions in specific cases.|comment:"Insulin decreased GLUT4 interactions with the following proteins: Q9ER30 (Sarcosin), P09527 (Rab-7), O88960 (N-ethylmaleimide sensitive), P09456 (PKA I regulatory subunit), P27881 (Hexokinase type II), P07872 (Acyl-coenzyme A oxidase), Q6DGF1 (Isocitrate dehydrogenase), Q9EQX9 (Ubiquitin-conjugating), Q63446 (Polyubiquitin), P24268 (Cathepsin D), Q91XW0 (Heat shock protein 86), Q5FVH0 (unknown), P58405 (Striatin 3), Q62667 (Major vault protein), Q66H50 (unknown), Q09167 (splicing factor), Q9JHU5 (Arfaptin 1)."|comment:"Insulin increased GLUT4 interaction with the following proteins:Q9Z1P2 (R-actinin-1), P45592 (Cofilin), Q9QXQ0 (R-actinin-4), P26473 (ADP-ribosylation factor), P26437 (ADP-ribosylation factor),   Q7TNP1 (Basigin 2), Q6P6R2 (Dihydrolipoamide dehydrogenase),   P04797 (GAPDH), Q63081 (Protein disulfide isomerase), P29457 (47 kDa heat shock protein), Q9R1J8 (Leprecan), O88638 (Putative eps protein),   Q64375 (Synaptonemal complex)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:NDPK - Interactions involving proteins containing InterPro domain IPR001564, Nucleoside diphosphate kinase, core.	taxid:10116(rat-l6)|taxid:10116(Rattus norvegicus)	-	2006/02/15	2021/11/30	rogid:PbFY2lfrty8yw40Jq7ShR7xfuV410116	rogid:C+EzS02H/FYMX2nyfksXpRMs8G010116	intact-crc:44F3A2176D02515F|rigid:9RVm0UBcqQF4k06RGKO89Bg16Q8	false	myc tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P19357	uniprotkb:P61589	intact:EBI-915426|uniprotkb:P97900|ensembl:ENSRNOP00000023256	intact:EBI-917892|ensembl:ENSRNOP00000066672	psi-mi:glut4_rat(display_long)|uniprotkb:Glucose transporter type 4, insulin-responsive(gene name synonym)|uniprotkb:Slc2a4(gene name)|psi-mi:Slc2a4(display_short)|uniprotkb:Glut4(gene name synonym)	psi-mi:rhoa_rat(display_long)|uniprotkb:Rhoa(gene name)|psi-mi:Rhoa(display_short)|uniprotkb:Arha(gene name synonym)|uniprotkb:Arha2(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Foster et al. (2006)	pubmed:16396496|mint:MINT-5218203	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-921030	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2711|refseq:NP_036883.1|refseq:XP_006246658.1|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007611"(learning or memory)|go:"GO:0007614"(short-term memory)|go:"GO:0007616"(long-term memory)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010021"(amylopectin biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031550"(positive regulation of brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044381"(glucose import in response to insulin stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046323"(glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0098694"(regulation of synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0098793"(presynapse)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002441("Glucose transporter, type 4 (GLUT4)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-189200|ensembl:ENSRNOG00000017226(gene)|ensembl:ENSRNOT00000023256(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)	rgd:619921|refseq:NP_476473.1|refseq:XP_006243761.1|refseq:XP_006243762.1|refseq:XP_006243763.1|ensembl:ENSRNOG00000050519(gene)|ensembl:ENSRNOT00000071664(transcript)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001822"(kidney development)|go:"GO:0001998"(angiotensin-mediated vasoconstriction involved in regulation of systemic arterial blood pressure)|go:"GO:0002363"(alpha-beta T cell lineage commitment)|go:"GO:0003100"(regulation of systemic arterial blood pressure by endothelin)|go:"GO:0003924"(GTPase activity)|go:"GO:0003925"(G protein activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005938"(cell cortex)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007015"(actin filament organization)|go:"GO:0007155"(cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007163"(establishment or maintenance of cell polarity)|go:"GO:0007266"(Rho protein signal transduction)|go:"GO:0007519"(skeletal muscle tissue development)|go:"GO:0008064"(regulation of actin polymerization or depolymerization)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0009612"(response to mechanical stimulus)|go:"GO:0009749"(response to glucose)|go:"GO:0010812"(negative regulation of cell-substrate adhesion)|go:"GO:0010975"(regulation of neuron projection development)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0016020"(membrane)|go:"GO:0016477"(cell migration)|go:"GO:0017022"(myosin binding)|go:"GO:0019003"(GDP binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0021795"(cerebral cortex cell migration)|go:"GO:0021861"(forebrain radial glial cell differentiation)|go:"GO:0030027"(lamellipodium)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030154"(cell differentiation)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030424"(axon)|go:"GO:0030496"(midbody)|go:"GO:0030521"(androgen receptor signaling pathway)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0030865"(cortical cytoskeleton organization)|go:"GO:0031098"(stress-activated protein kinase signaling cascade)|go:"GO:0031122"(cytoplasmic microtubule organization)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0031982"(vesicle)|go:"GO:0032154"(cleavage furrow)|go:"GO:0032467"(positive regulation of cytokinesis)|go:"GO:0032587"(ruffle membrane)|go:"GO:0032956"(regulation of actin cytoskeleton organization)|go:"GO:0033144"(negative regulation of intracellular steroid hormone receptor signaling pathway)|go:"GO:0033688"(regulation of osteoblast proliferation)|go:"GO:0034329"(cell junction assembly)|go:"GO:0034446"(substrate adhesion-dependent cell spreading)|go:"GO:0035385"(Roundabout signaling pathway)|go:"GO:0036089"(cleavage furrow formation)|go:"GO:0038027"(apolipoprotein A-I-mediated signaling pathway)|go:"GO:0042476"(odontogenesis)|go:"GO:0042493"|go:"GO:0042995"(cell projection)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043124"(negative regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043149"(stress fiber assembly)|go:"GO:0043197"(dendritic spine)|go:"GO:0043200"(response to amino acid)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043296"(apical junction complex)|go:"GO:0043297"(apical junction assembly)|go:"GO:0043366"(beta selection)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0043542"(endothelial cell migration)|go:"GO:0043931"(ossification involved in bone maturation)|go:"GO:0044319"(wound healing, spreading of cells)|go:"GO:0045198"(establishment of epithelial cell apical/basal polarity)|go:"GO:0045471"(response to ethanol)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0045666"(positive regulation of neuron differentiation)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0045792"(negative regulation of cell size)|go:"GO:0045907"(positive regulation of vasoconstriction)|go:"GO:0045987"(positive regulation of smooth muscle contraction)|go:"GO:0046039"(GTP metabolic process)|go:"GO:0046638"(positive regulation of alpha-beta T cell differentiation)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0050773"(regulation of dendrite development)|go:"GO:0050919"(negative chemotaxis)|go:"GO:0051022"(Rho GDP-dissociation inhibitor binding)|go:"GO:0051384"(response to glucocorticoid)|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0051924"(regulation of calcium ion transport)|go:"GO:0060193"(positive regulation of lipase activity)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0061383"(trabecula morphogenesis)|go:"GO:0070507"(regulation of microtubule cytoskeleton organization)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071345"(cellular response to cytokine stimulus)|go:"GO:0071393"(cellular response to progesterone stimulus)|go:"GO:0071803"(positive regulation of podosome assembly)|go:"GO:0071902"(positive regulation of protein serine/threonine kinase activity)|go:"GO:0071944"(cell periphery)|go:"GO:0090051"(negative regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0090307"(mitotic spindle assembly)|go:"GO:0090324"(negative regulation of oxidative phosphorylation)|go:"GO:0097498"(endothelial tube lumen extension)|go:"GO:0098794"(postsynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:1902766"(skeletal muscle satellite cell migration)|go:"GO:1903427"(negative regulation of reactive oxygen species biosynthetic process)|go:"GO:1903673"(mitotic cleavage furrow formation)|go:"GO:1904695"(positive regulation of vascular associated smooth muscle contraction)|go:"GO:1904706"(negative regulation of vascular associated smooth muscle cell proliferation)|go:"GO:1904753"(negative regulation of vascular associated smooth muscle cell migration)|go:"GO:1904996"(positive regulation of leukocyte adhesion to vascular endothelial cell)|go:"GO:1905244"(regulation of modification of synaptic structure)|go:"GO:1905274"(regulation of modification of postsynaptic actin cytoskeleton)|go:"GO:1990869"(cellular response to chemokine)|go:"GO:2000177"(regulation of neural precursor cell proliferation)|go:"GO:2000406"(positive regulation of T cell migration)|interpro:IPR001806(Ras GTPase)|interpro:IPR003578(Ras small GTPase, Rho type)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR027417|mint:P61589|rcsb pdb:3TVD|reactome:R-RNO-114604|reactome:R-RNO-193634|reactome:R-RNO-198203|reactome:R-RNO-209563|reactome:R-RNO-2173791|reactome:R-RNO-392451|reactome:R-RNO-3928662|reactome:R-RNO-3928663|reactome:R-RNO-4086400|reactome:R-RNO-416482|reactome:R-RNO-416550|reactome:R-RNO-416572|reactome:R-RNO-4420097|reactome:R-RNO-5625740|reactome:R-RNO-5625900|reactome:R-RNO-5625970|reactome:R-RNO-5627117|reactome:R-RNO-5663220|reactome:R-RNO-5666185|reactome:R-RNO-5689896|reactome:R-RNO-6785631|reactome:R-RNO-6798695|reactome:R-RNO-8849471|reactome:R-RNO-8980692|reactome:R-RNO-8985586|reactome:R-RNO-9013106	-	-	-	caution:"The participant EBI-349571(P68370) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919386(Q7TP47) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920972(Q5XIP9) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-916419(P11980) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919578(Q8R491) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920554(Q5U3Z7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920647(Q5U2X8) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920585(Q7TP24) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-779677(P05426) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-915744(P02454) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|agonist:Insulin was shown to increase or decrease GLUT4 protein interactions in specific cases.|comment:"Insulin decreased GLUT4 interactions with the following proteins: Q9ER30 (Sarcosin), P09527 (Rab-7), O88960 (N-ethylmaleimide sensitive), P09456 (PKA I regulatory subunit), P27881 (Hexokinase type II), P07872 (Acyl-coenzyme A oxidase), Q6DGF1 (Isocitrate dehydrogenase), Q9EQX9 (Ubiquitin-conjugating), Q63446 (Polyubiquitin), P24268 (Cathepsin D), Q91XW0 (Heat shock protein 86), Q5FVH0 (unknown), P58405 (Striatin 3), Q62667 (Major vault protein), Q66H50 (unknown), Q09167 (splicing factor), Q9JHU5 (Arfaptin 1)."|comment:"Insulin increased GLUT4 interaction with the following proteins:Q9Z1P2 (R-actinin-1), P45592 (Cofilin), Q9QXQ0 (R-actinin-4), P26473 (ADP-ribosylation factor), P26437 (ADP-ribosylation factor),   Q7TNP1 (Basigin 2), Q6P6R2 (Dihydrolipoamide dehydrogenase),   P04797 (GAPDH), Q63081 (Protein disulfide isomerase), P29457 (47 kDa heat shock protein), Q9R1J8 (Leprecan), O88638 (Putative eps protein),   Q64375 (Synaptonemal complex)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:NDPK - Interactions involving proteins containing InterPro domain IPR001564, Nucleoside diphosphate kinase, core.	taxid:10116(rat-l6)|taxid:10116(Rattus norvegicus)	-	2006/02/15	2021/11/30	rogid:PbFY2lfrty8yw40Jq7ShR7xfuV410116	rogid:HKBQaI187g5GnvTF9bilOaiTaXM10116	intact-crc:44F3A2176D02515F|rigid:9RVm0UBcqQF4k06RGKO89Bg16Q8	false	myc tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P19357	uniprotkb:O54980	intact:EBI-915426|uniprotkb:P97900|ensembl:ENSRNOP00000023256	intact:EBI-915595	psi-mi:glut4_rat(display_long)|uniprotkb:Glucose transporter type 4, insulin-responsive(gene name synonym)|uniprotkb:Slc2a4(gene name)|psi-mi:Slc2a4(display_short)|uniprotkb:Glut4(gene name synonym)	psi-mi:sng2_rat(display_long)|uniprotkb:Cellugyrin(gene name synonym)|uniprotkb:Syngr2(gene name)|psi-mi:Syngr2(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Foster et al. (2006)	pubmed:16396496|mint:MINT-5218203	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-921030	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2711|refseq:NP_036883.1|refseq:XP_006246658.1|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007611"(learning or memory)|go:"GO:0007614"(short-term memory)|go:"GO:0007616"(long-term memory)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010021"(amylopectin biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031550"(positive regulation of brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044381"(glucose import in response to insulin stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046323"(glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0098694"(regulation of synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0098793"(presynapse)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002441("Glucose transporter, type 4 (GLUT4)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-189200|ensembl:ENSRNOG00000017226(gene)|ensembl:ENSRNOT00000023256(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)	interpro:IPR008253(Marvel)|interpro:IPR016579(Synaptogyrin)|rgd:621334|refseq:NP_446005.1|go:"GO:0006605"(protein targeting)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0045055"(regulated exocytosis)|go:"GO:0048499"(synaptic vesicle membrane organization)	-	-	-	caution:"The participant EBI-349571(P68370) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919386(Q7TP47) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920972(Q5XIP9) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-916419(P11980) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919578(Q8R491) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920554(Q5U3Z7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920647(Q5U2X8) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920585(Q7TP24) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-779677(P05426) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-915744(P02454) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|agonist:Insulin was shown to increase or decrease GLUT4 protein interactions in specific cases.|comment:"Insulin decreased GLUT4 interactions with the following proteins: Q9ER30 (Sarcosin), P09527 (Rab-7), O88960 (N-ethylmaleimide sensitive), P09456 (PKA I regulatory subunit), P27881 (Hexokinase type II), P07872 (Acyl-coenzyme A oxidase), Q6DGF1 (Isocitrate dehydrogenase), Q9EQX9 (Ubiquitin-conjugating), Q63446 (Polyubiquitin), P24268 (Cathepsin D), Q91XW0 (Heat shock protein 86), Q5FVH0 (unknown), P58405 (Striatin 3), Q62667 (Major vault protein), Q66H50 (unknown), Q09167 (splicing factor), Q9JHU5 (Arfaptin 1)."|comment:"Insulin increased GLUT4 interaction with the following proteins:Q9Z1P2 (R-actinin-1), P45592 (Cofilin), Q9QXQ0 (R-actinin-4), P26473 (ADP-ribosylation factor), P26437 (ADP-ribosylation factor),   Q7TNP1 (Basigin 2), Q6P6R2 (Dihydrolipoamide dehydrogenase),   P04797 (GAPDH), Q63081 (Protein disulfide isomerase), P29457 (47 kDa heat shock protein), Q9R1J8 (Leprecan), O88638 (Putative eps protein),   Q64375 (Synaptonemal complex)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:NDPK - Interactions involving proteins containing InterPro domain IPR001564, Nucleoside diphosphate kinase, core.	taxid:10116(rat-l6)|taxid:10116(Rattus norvegicus)	-	2006/02/15	2021/11/30	rogid:PbFY2lfrty8yw40Jq7ShR7xfuV410116	rogid:k2RzDyC/YIK+AKG39BUmNmYlA9I10116	intact-crc:44F3A2176D02515F|rigid:9RVm0UBcqQF4k06RGKO89Bg16Q8	false	myc tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P19357	uniprotkb:O54861	intact:EBI-915426|uniprotkb:P97900|ensembl:ENSRNOP00000023256	intact:EBI-915580|uniprotkb:O35389|ensembl:ENSRNOP00000051102	psi-mi:glut4_rat(display_long)|uniprotkb:Glucose transporter type 4, insulin-responsive(gene name synonym)|uniprotkb:Slc2a4(gene name)|psi-mi:Slc2a4(display_short)|uniprotkb:Glut4(gene name synonym)	psi-mi:sort_rat(display_long)|uniprotkb:Neurotensin receptor 3(gene name synonym)|uniprotkb:Glycoprotein 110(gene name synonym)|uniprotkb:Sort1(gene name)|psi-mi:Sort1(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Foster et al. (2006)	pubmed:16396496|mint:MINT-5218203	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-921030	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2711|refseq:NP_036883.1|refseq:XP_006246658.1|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007611"(learning or memory)|go:"GO:0007614"(short-term memory)|go:"GO:0007616"(long-term memory)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010021"(amylopectin biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031550"(positive regulation of brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044381"(glucose import in response to insulin stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046323"(glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0098694"(regulation of synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0098793"(presynapse)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002441("Glucose transporter, type 4 (GLUT4)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-189200|ensembl:ENSRNOG00000017226(gene)|ensembl:ENSRNOT00000023256(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)	rgd:619999|refseq:NP_113955.1|ensembl:ENSRNOG00000031814(gene)|ensembl:ENSRNOT00000049127(transcript)|go:"GO:0001503"(ossification)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005769"(early endosome)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0006622"(protein targeting to lysosome)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006892"(post-Golgi vesicle-mediated transport)|go:"GO:0006895"(Golgi to endosome transport)|go:"GO:0006897"(endocytosis)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007218"(neuropeptide signaling pathway)|go:"GO:0008333"(endosome to lysosome transport)|go:"GO:0008625"(extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:0009986"(cell surface)|go:"GO:0010008"(endosome membrane)|go:"GO:0010465"(nerve growth factor receptor activity)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0014902"(myotube differentiation)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016050"(vesicle organization)|go:"GO:0016492"(G protein-coupled neurotensin receptor activity)|go:"GO:0019899"(enzyme binding)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030379"(neurotensin receptor activity, non-G protein-coupled)|go:"GO:0030425"(dendrite)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032509"(endosome transport via multivesicular body sorting pathway)|go:"GO:0032580"(Golgi cisterna membrane)|go:"GO:0032868"(response to insulin)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045599"(negative regulation of fat cell differentiation)|go:"GO:0046323"(glucose import)|go:"GO:0048011"(neurotrophin TRK receptor signaling pathway)|go:"GO:0048227"(plasma membrane to endosome transport)|go:"GO:0048406"(nerve growth factor binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051005"(negative regulation of lipoprotein lipase activity)|go:"GO:0090160"(Golgi to lysosome transport)|go:"GO:1904037"(positive regulation of epithelial cell apoptotic process)|go:"GO:1905394"(retromer complex binding)|interpro:IPR006581(VPS10)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR031777|interpro:IPR031778|mint:O54861|reactome:R-RNO-432722	-	-	-	caution:"The participant EBI-349571(P68370) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919386(Q7TP47) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920972(Q5XIP9) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-916419(P11980) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919578(Q8R491) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920554(Q5U3Z7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920647(Q5U2X8) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920585(Q7TP24) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-779677(P05426) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-915744(P02454) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|agonist:Insulin was shown to increase or decrease GLUT4 protein interactions in specific cases.|comment:"Insulin decreased GLUT4 interactions with the following proteins: Q9ER30 (Sarcosin), P09527 (Rab-7), O88960 (N-ethylmaleimide sensitive), P09456 (PKA I regulatory subunit), P27881 (Hexokinase type II), P07872 (Acyl-coenzyme A oxidase), Q6DGF1 (Isocitrate dehydrogenase), Q9EQX9 (Ubiquitin-conjugating), Q63446 (Polyubiquitin), P24268 (Cathepsin D), Q91XW0 (Heat shock protein 86), Q5FVH0 (unknown), P58405 (Striatin 3), Q62667 (Major vault protein), Q66H50 (unknown), Q09167 (splicing factor), Q9JHU5 (Arfaptin 1)."|comment:"Insulin increased GLUT4 interaction with the following proteins:Q9Z1P2 (R-actinin-1), P45592 (Cofilin), Q9QXQ0 (R-actinin-4), P26473 (ADP-ribosylation factor), P26437 (ADP-ribosylation factor),   Q7TNP1 (Basigin 2), Q6P6R2 (Dihydrolipoamide dehydrogenase),   P04797 (GAPDH), Q63081 (Protein disulfide isomerase), P29457 (47 kDa heat shock protein), Q9R1J8 (Leprecan), O88638 (Putative eps protein),   Q64375 (Synaptonemal complex)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:NDPK - Interactions involving proteins containing InterPro domain IPR001564, Nucleoside diphosphate kinase, core.	taxid:10116(rat-l6)|taxid:10116(Rattus norvegicus)	-	2006/02/15	2021/11/30	rogid:PbFY2lfrty8yw40Jq7ShR7xfuV410116	rogid:3DR0ZaBcQurHYvbpi0KIjQZ665010116	intact-crc:44F3A2176D02515F|rigid:9RVm0UBcqQF4k06RGKO89Bg16Q8	false	myc tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P19357	uniprotkb:O54715	intact:EBI-915426|uniprotkb:P97900|ensembl:ENSRNOP00000023256	intact:EBI-915573	psi-mi:glut4_rat(display_long)|uniprotkb:Glucose transporter type 4, insulin-responsive(gene name synonym)|uniprotkb:Slc2a4(gene name)|psi-mi:Slc2a4(display_short)|uniprotkb:Glut4(gene name synonym)	psi-mi:vas1_rat(display_long)|uniprotkb:V-ATPase S1 accessory protein(gene name synonym)|uniprotkb:V-ATPase Ac45 subunit(gene name synonym)|uniprotkb:C7-1 protein(gene name synonym)|uniprotkb:Atp6ap1(gene name)|psi-mi:Atp6ap1(display_short)|uniprotkb:Atp6ip1(gene name synonym)|uniprotkb:Atp6s1(gene name synonym)|uniprotkb:Vacuolar proton pump subunit S1(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Foster et al. (2006)	pubmed:16396496|mint:MINT-5218203	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-921030	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2711|refseq:NP_036883.1|refseq:XP_006246658.1|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007611"(learning or memory)|go:"GO:0007614"(short-term memory)|go:"GO:0007616"(long-term memory)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010021"(amylopectin biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031550"(positive regulation of brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044381"(glucose import in response to insulin stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046323"(glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0098694"(regulation of synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0098793"(presynapse)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002441("Glucose transporter, type 4 (GLUT4)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-189200|ensembl:ENSRNOG00000017226(gene)|ensembl:ENSRNOT00000023256(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)	interpro:IPR008388(ATPase, V1 complex, subunit S1)|rgd:620423|refseq:NP_113973.1|mint:O54715|go:"GO:0005524"(ATP binding)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0006879"(cellular iron ion homeostasis)|go:"GO:0007568"(aging)|go:"GO:0008219"(cell death)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030641"(regulation of cellular pH)|go:"GO:0031267"(small GTPase binding)|go:"GO:0033116"(endoplasmic reticulum-Golgi intermediate compartment membrane)|go:"GO:0033180"(proton-transporting V-type ATPase, V1 domain)|go:"GO:0033181"(plasma membrane proton-transporting V-type ATPase complex)|go:"GO:0036295"(cellular response to increased oxygen levels)|go:"GO:0045669"(positive regulation of osteoblast differentiation)|go:"GO:0045780"(positive regulation of bone resorption)|go:"GO:0045851"(pH reduction)|go:"GO:0045921"(positive regulation of exocytosis)|go:"GO:0051656"(establishment of organelle localization)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:1902600"(proton transmembrane transport)|go:"GO:2001206"(positive regulation of osteoclast development)|rcsb pdb:6VQ6|rcsb pdb:6VQ7|rcsb pdb:6VQ8|rcsb pdb:6VQC|rcsb pdb:6VQG|rcsb pdb:6VQH|reactome:R-RNO-77387|reactome:R-RNO-8980692|reactome:R-RNO-917977|reactome:R-RNO-983712	-	-	-	caution:"The participant EBI-349571(P68370) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919386(Q7TP47) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920972(Q5XIP9) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-916419(P11980) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919578(Q8R491) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920554(Q5U3Z7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920647(Q5U2X8) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920585(Q7TP24) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-779677(P05426) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-915744(P02454) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|agonist:Insulin was shown to increase or decrease GLUT4 protein interactions in specific cases.|comment:"Insulin decreased GLUT4 interactions with the following proteins: Q9ER30 (Sarcosin), P09527 (Rab-7), O88960 (N-ethylmaleimide sensitive), P09456 (PKA I regulatory subunit), P27881 (Hexokinase type II), P07872 (Acyl-coenzyme A oxidase), Q6DGF1 (Isocitrate dehydrogenase), Q9EQX9 (Ubiquitin-conjugating), Q63446 (Polyubiquitin), P24268 (Cathepsin D), Q91XW0 (Heat shock protein 86), Q5FVH0 (unknown), P58405 (Striatin 3), Q62667 (Major vault protein), Q66H50 (unknown), Q09167 (splicing factor), Q9JHU5 (Arfaptin 1)."|comment:"Insulin increased GLUT4 interaction with the following proteins:Q9Z1P2 (R-actinin-1), P45592 (Cofilin), Q9QXQ0 (R-actinin-4), P26473 (ADP-ribosylation factor), P26437 (ADP-ribosylation factor),   Q7TNP1 (Basigin 2), Q6P6R2 (Dihydrolipoamide dehydrogenase),   P04797 (GAPDH), Q63081 (Protein disulfide isomerase), P29457 (47 kDa heat shock protein), Q9R1J8 (Leprecan), O88638 (Putative eps protein),   Q64375 (Synaptonemal complex)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:NDPK - Interactions involving proteins containing InterPro domain IPR001564, Nucleoside diphosphate kinase, core.	taxid:10116(rat-l6)|taxid:10116(Rattus norvegicus)	-	2006/02/15	2021/11/30	rogid:PbFY2lfrty8yw40Jq7ShR7xfuV410116	rogid:SQbhwQxTt+SDeOiaf5IuR0kMVHU10116	intact-crc:44F3A2176D02515F|rigid:9RVm0UBcqQF4k06RGKO89Bg16Q8	false	myc tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P19357	uniprotkb:O35854	intact:EBI-915426|uniprotkb:P97900|ensembl:ENSRNOP00000023256	intact:EBI-915562	psi-mi:glut4_rat(display_long)|uniprotkb:Glucose transporter type 4, insulin-responsive(gene name synonym)|uniprotkb:Slc2a4(gene name)|psi-mi:Slc2a4(display_short)|uniprotkb:Glut4(gene name synonym)	psi-mi:bcat2_rat(display_long)|uniprotkb:Bcat2(gene name)|psi-mi:Bcat2(display_short)|uniprotkb:Bcatm(gene name synonym)|uniprotkb:Eca40(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Foster et al. (2006)	pubmed:16396496|mint:MINT-5218203	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-921030	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2711|refseq:NP_036883.1|refseq:XP_006246658.1|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007611"(learning or memory)|go:"GO:0007614"(short-term memory)|go:"GO:0007616"(long-term memory)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010021"(amylopectin biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031550"(positive regulation of brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044381"(glucose import in response to insulin stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046323"(glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0098694"(regulation of synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0098793"(presynapse)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002441("Glucose transporter, type 4 (GLUT4)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-189200|ensembl:ENSRNOG00000017226(gene)|ensembl:ENSRNOT00000023256(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)	rgd:68948|refseq:NP_071795.1|interpro:IPR001544(Aminotransferase, class IV)|interpro:IPR018300|interpro:IPR005786(Branched-chain amino acid aminotransferase II)|interpro:IPR043131|interpro:IPR043132|interpro:IPR033939|interpro:IPR036038|reactome:R-RNO-70895|go:"GO:0004084"(branched-chain-amino-acid transaminase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0006549"(isoleucine metabolic process)|go:"GO:0006550"(isoleucine catabolic process)|go:"GO:0006551"(leucine metabolic process)|go:"GO:0006573"(valine metabolic process)|go:"GO:0007595"(lactation)|go:"GO:0009081"(branched-chain amino acid metabolic process)|go:"GO:0009082"(branched-chain amino acid biosynthetic process)|go:"GO:0009083"(branched-chain amino acid catabolic process)|go:"GO:0009098"(leucine biosynthetic process)|go:"GO:0009099"(valine biosynthetic process)|go:"GO:0010817"(regulation of hormone levels)|go:"GO:0050048"("L-leucine:2-oxoglutarate aminotransferase activity")|go:"GO:0052654"(L-leucine transaminase activity)|go:"GO:0052655"(L-valine transaminase activity)|go:"GO:0052656"(L-isoleucine transaminase activity)|go:"GO:1990830"(cellular response to leukemia inhibitory factor)	-	-	-	caution:"The participant EBI-349571(P68370) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919386(Q7TP47) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920972(Q5XIP9) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-916419(P11980) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919578(Q8R491) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920554(Q5U3Z7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920647(Q5U2X8) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920585(Q7TP24) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-779677(P05426) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-915744(P02454) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|agonist:Insulin was shown to increase or decrease GLUT4 protein interactions in specific cases.|comment:"Insulin decreased GLUT4 interactions with the following proteins: Q9ER30 (Sarcosin), P09527 (Rab-7), O88960 (N-ethylmaleimide sensitive), P09456 (PKA I regulatory subunit), P27881 (Hexokinase type II), P07872 (Acyl-coenzyme A oxidase), Q6DGF1 (Isocitrate dehydrogenase), Q9EQX9 (Ubiquitin-conjugating), Q63446 (Polyubiquitin), P24268 (Cathepsin D), Q91XW0 (Heat shock protein 86), Q5FVH0 (unknown), P58405 (Striatin 3), Q62667 (Major vault protein), Q66H50 (unknown), Q09167 (splicing factor), Q9JHU5 (Arfaptin 1)."|comment:"Insulin increased GLUT4 interaction with the following proteins:Q9Z1P2 (R-actinin-1), P45592 (Cofilin), Q9QXQ0 (R-actinin-4), P26473 (ADP-ribosylation factor), P26437 (ADP-ribosylation factor),   Q7TNP1 (Basigin 2), Q6P6R2 (Dihydrolipoamide dehydrogenase),   P04797 (GAPDH), Q63081 (Protein disulfide isomerase), P29457 (47 kDa heat shock protein), Q9R1J8 (Leprecan), O88638 (Putative eps protein),   Q64375 (Synaptonemal complex)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:NDPK - Interactions involving proteins containing InterPro domain IPR001564, Nucleoside diphosphate kinase, core.	taxid:10116(rat-l6)|taxid:10116(Rattus norvegicus)	-	2006/02/15	2021/11/30	rogid:PbFY2lfrty8yw40Jq7ShR7xfuV410116	rogid:SBAI3GFtZDbV0y1zbS0y7YpoOy810116	intact-crc:44F3A2176D02515F|rigid:9RVm0UBcqQF4k06RGKO89Bg16Q8	false	myc tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P19357	uniprotkb:Q6IFV1	intact:EBI-915426|uniprotkb:P97900|ensembl:ENSRNOP00000023256	intact:EBI-915552|uniprotkb:O35813|ensembl:ENSRNOP00000005285	psi-mi:glut4_rat(display_long)|uniprotkb:Glucose transporter type 4, insulin-responsive(gene name synonym)|uniprotkb:Slc2a4(gene name)|psi-mi:Slc2a4(display_short)|uniprotkb:Glut4(gene name synonym)	psi-mi:k1c14_rat(display_long)|uniprotkb:Keratin-14(gene name synonym)|uniprotkb:Cytokeratin-14(gene name synonym)|uniprotkb:Type I keratin Ka14(gene name synonym)|uniprotkb:Krt14(gene name)|psi-mi:Krt14(display_short)|uniprotkb:Ka14(gene name synonym)|uniprotkb:Krt1-14(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Foster et al. (2006)	pubmed:16396496|mint:MINT-5218203	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-921030	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2711|refseq:NP_036883.1|refseq:XP_006246658.1|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007611"(learning or memory)|go:"GO:0007614"(short-term memory)|go:"GO:0007616"(long-term memory)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010021"(amylopectin biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031550"(positive regulation of brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044381"(glucose import in response to insulin stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046323"(glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0098694"(regulation of synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0098793"(presynapse)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002441("Glucose transporter, type 4 (GLUT4)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-189200|ensembl:ENSRNOG00000017226(gene)|ensembl:ENSRNOT00000023256(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)	rgd:1307463|refseq:NP_001008751.1|ensembl:ENSRNOG00000003899(gene)|ensembl:ENSRNOT00000005285(transcript)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005882"(intermediate filament)|go:"GO:0007568"(aging)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0030855"(epithelial cell differentiation)|go:"GO:0042633"(hair cycle)|go:"GO:0045095"(keratin filament)|go:"GO:0045110"(intermediate filament bundle assembly)|go:"GO:0045178"(basal part of cell)|go:"GO:0071944"(cell periphery)|go:"GO:1990254"(keratin filament binding)|interpro:IPR002957(Keratin, type I)|interpro:IPR018039|interpro:IPR039008|reactome:R-RNO-446107|reactome:R-RNO-6805567|reactome:R-RNO-6809371	-	-	-	caution:"The participant EBI-349571(P68370) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919386(Q7TP47) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920972(Q5XIP9) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-916419(P11980) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919578(Q8R491) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920554(Q5U3Z7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920647(Q5U2X8) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920585(Q7TP24) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-779677(P05426) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-915744(P02454) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|agonist:Insulin was shown to increase or decrease GLUT4 protein interactions in specific cases.|comment:"Insulin decreased GLUT4 interactions with the following proteins: Q9ER30 (Sarcosin), P09527 (Rab-7), O88960 (N-ethylmaleimide sensitive), P09456 (PKA I regulatory subunit), P27881 (Hexokinase type II), P07872 (Acyl-coenzyme A oxidase), Q6DGF1 (Isocitrate dehydrogenase), Q9EQX9 (Ubiquitin-conjugating), Q63446 (Polyubiquitin), P24268 (Cathepsin D), Q91XW0 (Heat shock protein 86), Q5FVH0 (unknown), P58405 (Striatin 3), Q62667 (Major vault protein), Q66H50 (unknown), Q09167 (splicing factor), Q9JHU5 (Arfaptin 1)."|comment:"Insulin increased GLUT4 interaction with the following proteins:Q9Z1P2 (R-actinin-1), P45592 (Cofilin), Q9QXQ0 (R-actinin-4), P26473 (ADP-ribosylation factor), P26437 (ADP-ribosylation factor),   Q7TNP1 (Basigin 2), Q6P6R2 (Dihydrolipoamide dehydrogenase),   P04797 (GAPDH), Q63081 (Protein disulfide isomerase), P29457 (47 kDa heat shock protein), Q9R1J8 (Leprecan), O88638 (Putative eps protein),   Q64375 (Synaptonemal complex)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:NDPK - Interactions involving proteins containing InterPro domain IPR001564, Nucleoside diphosphate kinase, core.	taxid:10116(rat-l6)|taxid:10116(Rattus norvegicus)	-	2006/02/15	2021/11/30	rogid:PbFY2lfrty8yw40Jq7ShR7xfuV410116	rogid:sSOkzVebK5FSAC4Kf+3tQQG5BpU10116	intact-crc:44F3A2176D02515F|rigid:9RVm0UBcqQF4k06RGKO89Bg16Q8	false	myc tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P19357	uniprotkb:O35796	intact:EBI-915426|uniprotkb:P97900|ensembl:ENSRNOP00000023256	intact:EBI-915544|uniprotkb:Q6IRS5|ensembl:ENSRNOP00000031020	psi-mi:glut4_rat(display_long)|uniprotkb:Glucose transporter type 4, insulin-responsive(gene name synonym)|uniprotkb:Slc2a4(gene name)|psi-mi:Slc2a4(display_short)|uniprotkb:Glut4(gene name synonym)	psi-mi:c1qbp_rat(display_long)|uniprotkb:Glycoprotein gC1qBP(gene name synonym)|uniprotkb:GC1q-R protein(gene name synonym)|uniprotkb:C1qbp(gene name)|psi-mi:C1qbp(display_short)|uniprotkb:Gc1qbp(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Foster et al. (2006)	pubmed:16396496|mint:MINT-5218203	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-921030	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2711|refseq:NP_036883.1|refseq:XP_006246658.1|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007611"(learning or memory)|go:"GO:0007614"(short-term memory)|go:"GO:0007616"(long-term memory)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010021"(amylopectin biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031550"(positive regulation of brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044381"(glucose import in response to insulin stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046323"(glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0098694"(regulation of synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0098793"(presynapse)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002441("Glucose transporter, type 4 (GLUT4)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-189200|ensembl:ENSRNOG00000017226(gene)|ensembl:ENSRNOT00000023256(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)	rgd:2230|refseq:NP_062132.2|ensembl:ENSRNOG00000006949(gene)|ensembl:ENSRNOT00000037517(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001849"(complement component C1q complex binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0003729"(mRNA binding)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005540"(hyaluronic acid binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006397"(mRNA processing)|go:"GO:0006915"(apoptotic process)|go:"GO:0006955"(immune response)|go:"GO:0006958"(complement activation, classical pathway)|go:"GO:0008380"(RNA splicing)|go:"GO:0008494"(translation activator activity)|go:"GO:0009986"(cell surface)|go:"GO:0014065"(phosphatidylinositol 3-kinase signaling)|go:"GO:0016020"(membrane)|go:"GO:0030449"(regulation of complement activation)|go:"GO:0030984"(kininogen binding)|go:"GO:0031690"(adrenergic receptor binding)|go:"GO:0032689"(negative regulation of interferon-gamma production)|go:"GO:0032695"(negative regulation of interleukin-12 production)|go:"GO:0039534"(negative regulation of MDA-5 signaling pathway)|go:"GO:0039536"(negative regulation of RIG-I signaling pathway)|go:"GO:0042256"(mature ribosome assembly)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0045087"(innate immune response)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0048025"(negative regulation of mRNA splicing, via spliceosome)|go:"GO:0048786"(presynaptic active zone)|go:"GO:0050687"(negative regulation of defense response to virus)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0070131"(positive regulation of mitochondrial translation)|go:"GO:0090023"(positive regulation of neutrophil chemotaxis)|go:"GO:0097177"(mitochondrial ribosome binding)|go:"GO:0098793"(presynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0098982"(GABA-ergic synapse)|go:"GO:1900026"(positive regulation of substrate adhesion-dependent cell spreading)|go:"GO:1901165"(positive regulation of trophoblast cell migration)|go:"GO:2000510"(positive regulation of dendritic cell chemotaxis)|interpro:IPR003428(Mitochondrial glycoprotein)|interpro:IPR036561|mint:O35796|reactome:R-RNO-140837|reactome:R-RNO-8980692|reactome:R-RNO-9013106	-	-	-	caution:"The participant EBI-349571(P68370) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919386(Q7TP47) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920972(Q5XIP9) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-916419(P11980) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919578(Q8R491) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920554(Q5U3Z7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920647(Q5U2X8) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920585(Q7TP24) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-779677(P05426) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-915744(P02454) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|agonist:Insulin was shown to increase or decrease GLUT4 protein interactions in specific cases.|comment:"Insulin decreased GLUT4 interactions with the following proteins: Q9ER30 (Sarcosin), P09527 (Rab-7), O88960 (N-ethylmaleimide sensitive), P09456 (PKA I regulatory subunit), P27881 (Hexokinase type II), P07872 (Acyl-coenzyme A oxidase), Q6DGF1 (Isocitrate dehydrogenase), Q9EQX9 (Ubiquitin-conjugating), Q63446 (Polyubiquitin), P24268 (Cathepsin D), Q91XW0 (Heat shock protein 86), Q5FVH0 (unknown), P58405 (Striatin 3), Q62667 (Major vault protein), Q66H50 (unknown), Q09167 (splicing factor), Q9JHU5 (Arfaptin 1)."|comment:"Insulin increased GLUT4 interaction with the following proteins:Q9Z1P2 (R-actinin-1), P45592 (Cofilin), Q9QXQ0 (R-actinin-4), P26473 (ADP-ribosylation factor), P26437 (ADP-ribosylation factor),   Q7TNP1 (Basigin 2), Q6P6R2 (Dihydrolipoamide dehydrogenase),   P04797 (GAPDH), Q63081 (Protein disulfide isomerase), P29457 (47 kDa heat shock protein), Q9R1J8 (Leprecan), O88638 (Putative eps protein),   Q64375 (Synaptonemal complex)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:NDPK - Interactions involving proteins containing InterPro domain IPR001564, Nucleoside diphosphate kinase, core.	taxid:10116(rat-l6)|taxid:10116(Rattus norvegicus)	-	2006/02/15	2021/11/30	rogid:PbFY2lfrty8yw40Jq7ShR7xfuV410116	rogid:t5x39iyP/nNXaEYhXq6vWYG7jP810116	intact-crc:44F3A2176D02515F|rigid:9RVm0UBcqQF4k06RGKO89Bg16Q8	false	myc tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P19357	uniprotkb:O35763	intact:EBI-915426|uniprotkb:P97900|ensembl:ENSRNOP00000023256	intact:EBI-915533	psi-mi:glut4_rat(display_long)|uniprotkb:Glucose transporter type 4, insulin-responsive(gene name synonym)|uniprotkb:Slc2a4(gene name)|psi-mi:Slc2a4(display_short)|uniprotkb:Glut4(gene name synonym)	psi-mi:moes_rat(display_long)|uniprotkb:Msn(gene name)|psi-mi:Msn(display_short)|uniprotkb:Membrane-organizing extension spike protein(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Foster et al. (2006)	pubmed:16396496|mint:MINT-5218203	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-921030	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2711|refseq:NP_036883.1|refseq:XP_006246658.1|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007611"(learning or memory)|go:"GO:0007614"(short-term memory)|go:"GO:0007616"(long-term memory)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010021"(amylopectin biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031550"(positive regulation of brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044381"(glucose import in response to insulin stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046323"(glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0098694"(regulation of synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0098793"(presynapse)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002441("Glucose transporter, type 4 (GLUT4)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-189200|ensembl:ENSRNOG00000017226(gene)|ensembl:ENSRNOT00000023256(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)	interpro:IPR000299(Band 4.1, N-terminal)|interpro:IPR018979|interpro:IPR018980|interpro:IPR008954(Moesin)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR019748|interpro:IPR019747|rgd:621260|refseq:NP_110490.1|interpro:IPR019749|interpro:IPR011174(Ezrin/radixin/moesin)|interpro:IPR011259(Ezrin/radixin/moesin, C-terminal)|interpro:IPR000798(Ezrin/radixin/moesin ERM)|interpro:IPR014352(FERM/acyl-CoA-binding protein, 3-helical bundle)|interpro:IPR029071|mint:O35763|interpro:IPR035963|interpro:IPR041789|go:"GO:0001771"(immunological synapse formation)|go:"GO:0001931"(uropod)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0003779"(actin binding)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005902"(microvillus)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0008361"(regulation of cell size)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0022612"(gland morphogenesis)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030315"(T-tubule)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0031143"(pseudopodium)|go:"GO:0031527"(filopodium membrane)|go:"GO:0031528"(microvillus membrane)|go:"GO:0042098"(T cell proliferation)|go:"GO:0045177"(apical part of cell)|go:"GO:0045198"(establishment of epithelial cell apical/basal polarity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050900"(leukocyte migration)|go:"GO:0051286"(cell tip)|go:"GO:0061028"(establishment of endothelial barrier)|go:"GO:0070489"(T cell aggregation)|go:"GO:0071394"(cellular response to testosterone stimulus)|go:"GO:0071803"(positive regulation of podosome assembly)|go:"GO:0071944"(cell periphery)|go:"GO:0072678"(T cell migration)|go:"GO:1902115"(regulation of organelle assembly)|go:"GO:1902966"(positive regulation of protein localization to early endosome)|go:"GO:1903364"(positive regulation of cellular protein catabolic process)|go:"GO:2000401"(regulation of lymphocyte migration)|go:"GO:2000643"(positive regulation of early endosome to late endosome transport)|reactome:R-RNO-437239	-	-	-	caution:"The participant EBI-349571(P68370) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919386(Q7TP47) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920972(Q5XIP9) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-916419(P11980) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919578(Q8R491) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920554(Q5U3Z7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920647(Q5U2X8) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920585(Q7TP24) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-779677(P05426) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-915744(P02454) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|agonist:Insulin was shown to increase or decrease GLUT4 protein interactions in specific cases.|comment:"Insulin decreased GLUT4 interactions with the following proteins: Q9ER30 (Sarcosin), P09527 (Rab-7), O88960 (N-ethylmaleimide sensitive), P09456 (PKA I regulatory subunit), P27881 (Hexokinase type II), P07872 (Acyl-coenzyme A oxidase), Q6DGF1 (Isocitrate dehydrogenase), Q9EQX9 (Ubiquitin-conjugating), Q63446 (Polyubiquitin), P24268 (Cathepsin D), Q91XW0 (Heat shock protein 86), Q5FVH0 (unknown), P58405 (Striatin 3), Q62667 (Major vault protein), Q66H50 (unknown), Q09167 (splicing factor), Q9JHU5 (Arfaptin 1)."|comment:"Insulin increased GLUT4 interaction with the following proteins:Q9Z1P2 (R-actinin-1), P45592 (Cofilin), Q9QXQ0 (R-actinin-4), P26473 (ADP-ribosylation factor), P26437 (ADP-ribosylation factor),   Q7TNP1 (Basigin 2), Q6P6R2 (Dihydrolipoamide dehydrogenase),   P04797 (GAPDH), Q63081 (Protein disulfide isomerase), P29457 (47 kDa heat shock protein), Q9R1J8 (Leprecan), O88638 (Putative eps protein),   Q64375 (Synaptonemal complex)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:NDPK - Interactions involving proteins containing InterPro domain IPR001564, Nucleoside diphosphate kinase, core.	taxid:10116(rat-l6)|taxid:10116(Rattus norvegicus)	-	2006/02/15	2021/11/30	rogid:PbFY2lfrty8yw40Jq7ShR7xfuV410116	rogid:5JGEl/oxEgX4eh5kE9+J394ontE10116	intact-crc:44F3A2176D02515F|rigid:9RVm0UBcqQF4k06RGKO89Bg16Q8	false	myc tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P19357	uniprotkb:O35511	intact:EBI-915426|uniprotkb:P97900|ensembl:ENSRNOP00000023256	intact:EBI-915525	psi-mi:glut4_rat(display_long)|uniprotkb:Glucose transporter type 4, insulin-responsive(gene name synonym)|uniprotkb:Slc2a4(gene name)|psi-mi:Slc2a4(display_short)|uniprotkb:Glut4(gene name synonym)	psi-mi:o35511_rat(display_long)|uniprotkb:PP2A ARa(gene name)|psi-mi:PP2A ARa(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Foster et al. (2006)	pubmed:16396496|mint:MINT-5218203	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-921030	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2711|refseq:NP_036883.1|refseq:XP_006246658.1|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007611"(learning or memory)|go:"GO:0007614"(short-term memory)|go:"GO:0007616"(long-term memory)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010021"(amylopectin biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031550"(positive regulation of brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044381"(glucose import in response to insulin stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046323"(glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0098694"(regulation of synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0098793"(presynapse)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002441("Glucose transporter, type 4 (GLUT4)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-189200|ensembl:ENSRNOG00000017226(gene)|ensembl:ENSRNOT00000023256(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)	interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR000357(HEAT)|interpro:IPR021133|interpro:IPR031090|mint:O35511|go:"GO:0019888"(protein phosphatase regulator activity)|go:"GO:0065003"(protein-containing complex assembly)	-	-	-	caution:"The participant EBI-349571(P68370) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919386(Q7TP47) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920972(Q5XIP9) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-916419(P11980) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919578(Q8R491) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920554(Q5U3Z7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920647(Q5U2X8) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920585(Q7TP24) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-779677(P05426) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-915744(P02454) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|agonist:Insulin was shown to increase or decrease GLUT4 protein interactions in specific cases.|comment:"Insulin decreased GLUT4 interactions with the following proteins: Q9ER30 (Sarcosin), P09527 (Rab-7), O88960 (N-ethylmaleimide sensitive), P09456 (PKA I regulatory subunit), P27881 (Hexokinase type II), P07872 (Acyl-coenzyme A oxidase), Q6DGF1 (Isocitrate dehydrogenase), Q9EQX9 (Ubiquitin-conjugating), Q63446 (Polyubiquitin), P24268 (Cathepsin D), Q91XW0 (Heat shock protein 86), Q5FVH0 (unknown), P58405 (Striatin 3), Q62667 (Major vault protein), Q66H50 (unknown), Q09167 (splicing factor), Q9JHU5 (Arfaptin 1)."|comment:"Insulin increased GLUT4 interaction with the following proteins:Q9Z1P2 (R-actinin-1), P45592 (Cofilin), Q9QXQ0 (R-actinin-4), P26473 (ADP-ribosylation factor), P26437 (ADP-ribosylation factor),   Q7TNP1 (Basigin 2), Q6P6R2 (Dihydrolipoamide dehydrogenase),   P04797 (GAPDH), Q63081 (Protein disulfide isomerase), P29457 (47 kDa heat shock protein), Q9R1J8 (Leprecan), O88638 (Putative eps protein),   Q64375 (Synaptonemal complex)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:NDPK - Interactions involving proteins containing InterPro domain IPR001564, Nucleoside diphosphate kinase, core.	taxid:10116(rat-l6)|taxid:10116(Rattus norvegicus)	-	2006/02/15	2021/11/30	rogid:PbFY2lfrty8yw40Jq7ShR7xfuV410116	rogid:s4ltXz9M5lOSpqOs4mO4V+v/cmM10116	intact-crc:44F3A2176D02515F|rigid:9RVm0UBcqQF4k06RGKO89Bg16Q8	false	myc tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P19357	uniprotkb:O35509	intact:EBI-915426|uniprotkb:P97900|ensembl:ENSRNOP00000023256	intact:EBI-915515|uniprotkb:Q9ET14|ensembl:ENSRNOP00000010197	psi-mi:glut4_rat(display_long)|uniprotkb:Glucose transporter type 4, insulin-responsive(gene name synonym)|uniprotkb:Slc2a4(gene name)|psi-mi:Slc2a4(display_short)|uniprotkb:Glut4(gene name synonym)	psi-mi:rb11b_rat(display_long)|uniprotkb:Rab11b(gene name)|psi-mi:Rab11b(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Foster et al. (2006)	pubmed:16396496|mint:MINT-5218203	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-921030	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2711|refseq:NP_036883.1|refseq:XP_006246658.1|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007611"(learning or memory)|go:"GO:0007614"(short-term memory)|go:"GO:0007616"(long-term memory)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010021"(amylopectin biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031550"(positive regulation of brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044381"(glucose import in response to insulin stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046323"(glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0098694"(regulation of synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0098793"(presynapse)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002441("Glucose transporter, type 4 (GLUT4)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-189200|ensembl:ENSRNOG00000017226(gene)|ensembl:ENSRNOT00000023256(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)	rgd:68369|refseq:NP_116006.1|ensembl:ENSRNOG00000007648(gene)|ensembl:ENSRNOT00000010197(transcript)|go:"GO:0001881"(receptor recycling)|go:"GO:0003924"(GTPase activity)|go:"GO:0003925"(G protein activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0006887"(exocytosis)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0019003"(GDP binding)|go:"GO:0030670"(phagocytic vesicle membrane)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031489"(myosin V binding)|go:"GO:0032402"(melanosome transport)|go:"GO:0032456"(endocytic recycling)|go:"GO:0033572"(transferrin transport)|go:"GO:0035773"(insulin secretion involved in cellular response to glucose stimulus)|go:"GO:0044070"(regulation of anion transport)|go:"GO:0045054"(constitutive secretory pathway)|go:"GO:0045055"(regulated exocytosis)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0055037"(recycling endosome)|go:"GO:0055038"(recycling endosome membrane)|go:"GO:0071468"(cellular response to acidic pH)|go:"GO:0090150"(establishment of protein localization to membrane)|go:"GO:0098993"(anchored component of synaptic vesicle membrane)|go:"GO:0150093"(amyloid-beta clearance by transcytosis)|go:"GO:2000008"(regulation of protein localization to cell surface)|go:"GO:2001135"(regulation of endocytic recycling)|interpro:IPR001806(Ras GTPase)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR027417|reactome:R-RNO-8854214|reactome:R-RNO-8873719	-	-	-	caution:"The participant EBI-349571(P68370) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919386(Q7TP47) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920972(Q5XIP9) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-916419(P11980) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919578(Q8R491) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920554(Q5U3Z7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920647(Q5U2X8) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920585(Q7TP24) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-779677(P05426) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-915744(P02454) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|agonist:Insulin was shown to increase or decrease GLUT4 protein interactions in specific cases.|comment:"Insulin decreased GLUT4 interactions with the following proteins: Q9ER30 (Sarcosin), P09527 (Rab-7), O88960 (N-ethylmaleimide sensitive), P09456 (PKA I regulatory subunit), P27881 (Hexokinase type II), P07872 (Acyl-coenzyme A oxidase), Q6DGF1 (Isocitrate dehydrogenase), Q9EQX9 (Ubiquitin-conjugating), Q63446 (Polyubiquitin), P24268 (Cathepsin D), Q91XW0 (Heat shock protein 86), Q5FVH0 (unknown), P58405 (Striatin 3), Q62667 (Major vault protein), Q66H50 (unknown), Q09167 (splicing factor), Q9JHU5 (Arfaptin 1)."|comment:"Insulin increased GLUT4 interaction with the following proteins:Q9Z1P2 (R-actinin-1), P45592 (Cofilin), Q9QXQ0 (R-actinin-4), P26473 (ADP-ribosylation factor), P26437 (ADP-ribosylation factor),   Q7TNP1 (Basigin 2), Q6P6R2 (Dihydrolipoamide dehydrogenase),   P04797 (GAPDH), Q63081 (Protein disulfide isomerase), P29457 (47 kDa heat shock protein), Q9R1J8 (Leprecan), O88638 (Putative eps protein),   Q64375 (Synaptonemal complex)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:NDPK - Interactions involving proteins containing InterPro domain IPR001564, Nucleoside diphosphate kinase, core.	taxid:10116(rat-l6)|taxid:10116(Rattus norvegicus)	-	2006/02/15	2021/11/30	rogid:PbFY2lfrty8yw40Jq7ShR7xfuV410116	rogid:+fsu7NPmd5fgoe0TE67IcISlscA10116	intact-crc:44F3A2176D02515F|rigid:9RVm0UBcqQF4k06RGKO89Bg16Q8	false	myc tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P19357	uniprotkb:Q5EGY4	intact:EBI-915426|uniprotkb:P97900|ensembl:ENSRNOP00000023256	intact:EBI-915507|uniprotkb:O35487|ensembl:ENSRNOP00000020693	psi-mi:glut4_rat(display_long)|uniprotkb:Glucose transporter type 4, insulin-responsive(gene name synonym)|uniprotkb:Slc2a4(gene name)|psi-mi:Slc2a4(display_short)|uniprotkb:Glut4(gene name synonym)	psi-mi:ykt6_rat(display_long)|uniprotkb:Ykt6(gene name)|psi-mi:Ykt6(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Foster et al. (2006)	pubmed:16396496|mint:MINT-5218203	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-921030	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2711|refseq:NP_036883.1|refseq:XP_006246658.1|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007611"(learning or memory)|go:"GO:0007614"(short-term memory)|go:"GO:0007616"(long-term memory)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010021"(amylopectin biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031550"(positive regulation of brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044381"(glucose import in response to insulin stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046323"(glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0098694"(regulation of synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0098793"(presynapse)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002441("Glucose transporter, type 4 (GLUT4)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-189200|ensembl:ENSRNOG00000017226(gene)|ensembl:ENSRNOT00000023256(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)	rgd:70897|refseq:NP_113880.2|ensembl:ENSRNOG00000014785(gene)|ensembl:ENSRNOT00000020693(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0005484"(SNAP receptor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005768"(endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006888"(endoplasmic reticulum to Golgi vesicle-mediated transport)|go:"GO:0006903"(vesicle targeting)|go:"GO:0006904"(vesicle docking involved in exocytosis)|go:"GO:0015031"(protein transport)|go:"GO:0016020"(membrane)|go:"GO:0019706"(protein-cysteine S-palmitoyltransferase activity)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031201"(SNARE complex)|go:"GO:0043025"(neuronal cell body)|go:"GO:0097440"(apical dendrite)|go:"GO:0097441"(basal dendrite)|interpro:IPR001388(Synaptobrevin)|interpro:IPR010908(Longin)|interpro:IPR011012(Longin-like)|interpro:IPR042855|rcsb pdb:3KYQ|reactome:R-RNO-204005|reactome:R-RNO-6807878|reactome:R-RNO-6811438|reactome:R-RNO-8980692|go:"GO:0042147"(retrograde transport, endosome to Golgi)|reactome:R-RNO-9013148|reactome:R-RNO-9013149|reactome:R-RNO-9013408|reactome:R-RNO-9013423	-	-	-	caution:"The participant EBI-349571(P68370) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919386(Q7TP47) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920972(Q5XIP9) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-916419(P11980) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919578(Q8R491) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920554(Q5U3Z7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920647(Q5U2X8) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920585(Q7TP24) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-779677(P05426) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-915744(P02454) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|agonist:Insulin was shown to increase or decrease GLUT4 protein interactions in specific cases.|comment:"Insulin decreased GLUT4 interactions with the following proteins: Q9ER30 (Sarcosin), P09527 (Rab-7), O88960 (N-ethylmaleimide sensitive), P09456 (PKA I regulatory subunit), P27881 (Hexokinase type II), P07872 (Acyl-coenzyme A oxidase), Q6DGF1 (Isocitrate dehydrogenase), Q9EQX9 (Ubiquitin-conjugating), Q63446 (Polyubiquitin), P24268 (Cathepsin D), Q91XW0 (Heat shock protein 86), Q5FVH0 (unknown), P58405 (Striatin 3), Q62667 (Major vault protein), Q66H50 (unknown), Q09167 (splicing factor), Q9JHU5 (Arfaptin 1)."|comment:"Insulin increased GLUT4 interaction with the following proteins:Q9Z1P2 (R-actinin-1), P45592 (Cofilin), Q9QXQ0 (R-actinin-4), P26473 (ADP-ribosylation factor), P26437 (ADP-ribosylation factor),   Q7TNP1 (Basigin 2), Q6P6R2 (Dihydrolipoamide dehydrogenase),   P04797 (GAPDH), Q63081 (Protein disulfide isomerase), P29457 (47 kDa heat shock protein), Q9R1J8 (Leprecan), O88638 (Putative eps protein),   Q64375 (Synaptonemal complex)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:NDPK - Interactions involving proteins containing InterPro domain IPR001564, Nucleoside diphosphate kinase, core.	taxid:10116(rat-l6)|taxid:10116(Rattus norvegicus)	-	2006/02/15	2021/11/30	rogid:PbFY2lfrty8yw40Jq7ShR7xfuV410116	rogid:zvwtiPzYkzRfETeKT/2k+q7Uvwk10116	intact-crc:44F3A2176D02515F|rigid:9RVm0UBcqQF4k06RGKO89Bg16Q8	false	myc tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P19357	uniprotkb:P16884	intact:EBI-915426|uniprotkb:P97900|ensembl:ENSRNOP00000023256	intact:EBI-446344|uniprotkb:O35482|uniprotkb:Q540Z7|uniprotkb:Q63368	psi-mi:glut4_rat(display_long)|uniprotkb:Glucose transporter type 4, insulin-responsive(gene name synonym)|uniprotkb:Slc2a4(gene name)|psi-mi:Slc2a4(display_short)|uniprotkb:Glut4(gene name synonym)	psi-mi:nfh_rat(display_long)|uniprotkb:Neurofilament triplet H protein(gene name synonym)|uniprotkb:200 kDa neurofilament protein(gene name synonym)|uniprotkb:Nefh(gene name)|psi-mi:Nefh(display_short)|uniprotkb:Nfh(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Foster et al. (2006)	pubmed:16396496|mint:MINT-5218203	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-921030	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2711|refseq:NP_036883.1|refseq:XP_006246658.1|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007611"(learning or memory)|go:"GO:0007614"(short-term memory)|go:"GO:0007616"(long-term memory)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010021"(amylopectin biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031550"(positive regulation of brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044381"(glucose import in response to insulin stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046323"(glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0098694"(regulation of synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0098793"(presynapse)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002441("Glucose transporter, type 4 (GLUT4)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-189200|ensembl:ENSRNOG00000017226(gene)|ensembl:ENSRNOT00000023256(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)	rgd:3159|dip:DIP-105N|mint:P16884|go:"GO:0007420"(brain development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015643"(toxic substance binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0021510"(spinal cord development)|go:"GO:0021766"(hippocampus development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030424"(axon)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0031103"(axon regeneration)|go:"GO:0031175"(neuron projection development)|go:"GO:0033693"(neurofilament bundle assembly)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0042220"(response to cocaine)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043204"(perikaryon)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045104"(intermediate filament cytoskeleton organization)|go:"GO:0045110"(intermediate filament bundle assembly)|go:"GO:0048936"(peripheral nervous system neuron axonogenesis)|go:"GO:0060052"(neurofilament cytoskeleton organization)|go:"GO:0061564"(axon development)|go:"GO:0071392"(cellular response to estradiol stimulus)|go:"GO:0071447"(cellular response to hydroperoxide)|go:"GO:0097418"(neurofibrillary tangle)|go:"GO:0097440"(apical dendrite)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0099160"(postsynaptic intermediate filament cytoskeleton)|go:"GO:0099184"(structural constituent of postsynaptic intermediate filament cytoskeleton)|go:"GO:0150017"(basal proximal dendrite)|go:"GO:1902513"(regulation of organelle transport along microtubule)|go:"GO:1903935"(response to sodium arsenite)|go:"GO:1903937"(response to acrylamide)|go:"GO:1990830"(cellular response to leukemia inhibitory factor)|interpro:IPR010790(Protein of unknown function DUF1388)|interpro:IPR018039|interpro:IPR033183|interpro:IPR039008|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0001552"(ovarian follicle atresia)|go:"GO:0005200"(structural constituent of cytoskeleton)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005882"(intermediate filament)|go:"GO:0005883"(neurofilament)	-	-	-	caution:"The participant EBI-349571(P68370) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919386(Q7TP47) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920972(Q5XIP9) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-916419(P11980) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919578(Q8R491) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920554(Q5U3Z7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920647(Q5U2X8) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920585(Q7TP24) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-779677(P05426) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-915744(P02454) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|agonist:Insulin was shown to increase or decrease GLUT4 protein interactions in specific cases.|comment:"Insulin decreased GLUT4 interactions with the following proteins: Q9ER30 (Sarcosin), P09527 (Rab-7), O88960 (N-ethylmaleimide sensitive), P09456 (PKA I regulatory subunit), P27881 (Hexokinase type II), P07872 (Acyl-coenzyme A oxidase), Q6DGF1 (Isocitrate dehydrogenase), Q9EQX9 (Ubiquitin-conjugating), Q63446 (Polyubiquitin), P24268 (Cathepsin D), Q91XW0 (Heat shock protein 86), Q5FVH0 (unknown), P58405 (Striatin 3), Q62667 (Major vault protein), Q66H50 (unknown), Q09167 (splicing factor), Q9JHU5 (Arfaptin 1)."|comment:"Insulin increased GLUT4 interaction with the following proteins:Q9Z1P2 (R-actinin-1), P45592 (Cofilin), Q9QXQ0 (R-actinin-4), P26473 (ADP-ribosylation factor), P26437 (ADP-ribosylation factor),   Q7TNP1 (Basigin 2), Q6P6R2 (Dihydrolipoamide dehydrogenase),   P04797 (GAPDH), Q63081 (Protein disulfide isomerase), P29457 (47 kDa heat shock protein), Q9R1J8 (Leprecan), O88638 (Putative eps protein),   Q64375 (Synaptonemal complex)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:NDPK - Interactions involving proteins containing InterPro domain IPR001564, Nucleoside diphosphate kinase, core.	taxid:10116(rat-l6)|taxid:10116(Rattus norvegicus)	-	2006/02/15	2021/11/30	rogid:PbFY2lfrty8yw40Jq7ShR7xfuV410116	rogid:ouBvM47wkf3tA9ZWmjX5jObpZtE10116	intact-crc:44F3A2176D02515F|rigid:9RVm0UBcqQF4k06RGKO89Bg16Q8	false	myc tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P19357	uniprotkb:O35264	intact:EBI-915426|uniprotkb:P97900|ensembl:ENSRNOP00000023256	intact:EBI-915500|ensembl:ENSRNOP00000068672	psi-mi:glut4_rat(display_long)|uniprotkb:Glucose transporter type 4, insulin-responsive(gene name synonym)|uniprotkb:Slc2a4(gene name)|psi-mi:Slc2a4(display_short)|uniprotkb:Glut4(gene name synonym)	psi-mi:pa1b2_rat(display_long)|uniprotkb:PAF acetylhydrolase 30 kDa subunit(gene name synonym)|uniprotkb:PAF-AH subunit beta(gene name synonym)|uniprotkb:Platelet-activating factor acetylhydrolase alpha 2 subunit(gene name synonym)|uniprotkb:Pafah1b2(gene name)|psi-mi:Pafah1b2(display_short)|uniprotkb:Pafahb(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Foster et al. (2006)	pubmed:16396496|mint:MINT-5218203	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-921030	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2711|refseq:NP_036883.1|refseq:XP_006246658.1|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007611"(learning or memory)|go:"GO:0007614"(short-term memory)|go:"GO:0007616"(long-term memory)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010021"(amylopectin biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031550"(positive regulation of brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044381"(glucose import in response to insulin stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046323"(glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0098694"(regulation of synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0098793"(presynapse)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002441("Glucose transporter, type 4 (GLUT4)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-189200|ensembl:ENSRNOG00000017226(gene)|ensembl:ENSRNOT00000023256(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)	rgd:620332|refseq:NP_071782.1|refseq:XP_006243020.1|ensembl:ENSRNOG00000057102(gene)|ensembl:ENSRNOT00000082508(transcript)|go:"GO:0001650"(fibrillar center)|go:"GO:0003847"(1-alkyl-2-acetylglycerophosphocholine esterase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007420"(brain development)|go:"GO:0008247"(1-alkyl-2-acetylglycerophosphocholine esterase complex)|go:"GO:0016042"(lipid catabolic process)|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0047179"(platelet-activating factor acetyltransferase activity)|interpro:IPR013830(Esterase, SGNH hydrolase-type)|interpro:IPR036514|reactome:R-RNO-6798695|reactome:R-RNO-6811436	-	-	-	caution:"The participant EBI-349571(P68370) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919386(Q7TP47) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920972(Q5XIP9) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-916419(P11980) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919578(Q8R491) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920554(Q5U3Z7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920647(Q5U2X8) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920585(Q7TP24) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-779677(P05426) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-915744(P02454) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|agonist:Insulin was shown to increase or decrease GLUT4 protein interactions in specific cases.|comment:"Insulin decreased GLUT4 interactions with the following proteins: Q9ER30 (Sarcosin), P09527 (Rab-7), O88960 (N-ethylmaleimide sensitive), P09456 (PKA I regulatory subunit), P27881 (Hexokinase type II), P07872 (Acyl-coenzyme A oxidase), Q6DGF1 (Isocitrate dehydrogenase), Q9EQX9 (Ubiquitin-conjugating), Q63446 (Polyubiquitin), P24268 (Cathepsin D), Q91XW0 (Heat shock protein 86), Q5FVH0 (unknown), P58405 (Striatin 3), Q62667 (Major vault protein), Q66H50 (unknown), Q09167 (splicing factor), Q9JHU5 (Arfaptin 1)."|comment:"Insulin increased GLUT4 interaction with the following proteins:Q9Z1P2 (R-actinin-1), P45592 (Cofilin), Q9QXQ0 (R-actinin-4), P26473 (ADP-ribosylation factor), P26437 (ADP-ribosylation factor),   Q7TNP1 (Basigin 2), Q6P6R2 (Dihydrolipoamide dehydrogenase),   P04797 (GAPDH), Q63081 (Protein disulfide isomerase), P29457 (47 kDa heat shock protein), Q9R1J8 (Leprecan), O88638 (Putative eps protein),   Q64375 (Synaptonemal complex)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:NDPK - Interactions involving proteins containing InterPro domain IPR001564, Nucleoside diphosphate kinase, core.	taxid:10116(rat-l6)|taxid:10116(Rattus norvegicus)	-	2006/02/15	2021/11/30	rogid:PbFY2lfrty8yw40Jq7ShR7xfuV410116	rogid:5Y3KS/c8AfWOl2IbXGIHjjVw89g10116	intact-crc:44F3A2176D02515F|rigid:9RVm0UBcqQF4k06RGKO89Bg16Q8	false	myc tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P19357	uniprotkb:O35244	intact:EBI-915426|uniprotkb:P97900|ensembl:ENSRNOP00000023256	intact:EBI-915490|ensembl:ENSRNOP00000030323	psi-mi:glut4_rat(display_long)|uniprotkb:Glucose transporter type 4, insulin-responsive(gene name synonym)|uniprotkb:Slc2a4(gene name)|psi-mi:Slc2a4(display_short)|uniprotkb:Glut4(gene name synonym)	psi-mi:prdx6_rat(display_long)|uniprotkb:Antioxidant protein 2(gene name synonym)|uniprotkb:1-Cys peroxiredoxin(gene name synonym)|uniprotkb:Acidic calcium-independent phospholipase A2(gene name synonym)|uniprotkb:Non-selenium glutathione peroxidase(gene name synonym)|uniprotkb:Thiol-specific antioxidant protein(gene name synonym)|uniprotkb:Prdx6(gene name)|psi-mi:Prdx6(display_short)|uniprotkb:Aipla2(gene name synonym)|uniprotkb:Aop2(gene name synonym)|uniprotkb:Tsa(gene name synonym)|uniprotkb:Glutathione-dependent peroxiredoxin(gene name synonym)|uniprotkb:Lysophosphatidylcholine acyltransferase 5(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Foster et al. (2006)	pubmed:16396496|mint:MINT-5218203	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-921030	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2711|refseq:NP_036883.1|refseq:XP_006246658.1|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007611"(learning or memory)|go:"GO:0007614"(short-term memory)|go:"GO:0007616"(long-term memory)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010021"(amylopectin biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031550"(positive regulation of brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044381"(glucose import in response to insulin stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046323"(glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0098694"(regulation of synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0098793"(presynapse)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002441("Glucose transporter, type 4 (GLUT4)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-189200|ensembl:ENSRNOG00000017226(gene)|ensembl:ENSRNOT00000023256(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)	rgd:71005|refseq:NP_446028.1|ensembl:ENSRNOG00000002896(gene)|ensembl:ENSRNOT00000034583(transcript)|go:"GO:0000302"(response to reactive oxygen species)|go:"GO:0004601"(peroxidase activity)|go:"GO:0004602"(glutathione peroxidase activity)|go:"GO:0004623"(phospholipase A2 activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005764"(lysosome)|go:"GO:0005829"(cytosol)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032060"(bleb assembly)|go:"GO:0042744"(hydrogen peroxide catabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0045454"(cell redox homeostasis)|go:"GO:0046475"(glycerophospholipid catabolic process)|go:"GO:0047184"(1-acylglycerophosphocholine O-acyltransferase activity)|go:"GO:0047499"(calcium-independent phospholipase A2 activity)|go:"GO:0048026"(positive regulation of mRNA splicing, via spliceosome)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051920"(peroxiredoxin activity)|go:"GO:0098869"(cellular oxidant detoxification)|go:"GO:0102567"|go:"GO:0102568"|interpro:IPR000866(Alkyl hydroperoxide reductase/ Thiol specific antioxidant/ Mal allergen)|interpro:IPR013766(Thioredoxin domain)|interpro:IPR019479|interpro:IPR024706|interpro:IPR036249|mint:O35244|reactome:R-RNO-3299685|reactome:R-RNO-6798695	-	-	-	caution:"The participant EBI-349571(P68370) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919386(Q7TP47) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920972(Q5XIP9) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-916419(P11980) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919578(Q8R491) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920554(Q5U3Z7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920647(Q5U2X8) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920585(Q7TP24) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-779677(P05426) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-915744(P02454) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|agonist:Insulin was shown to increase or decrease GLUT4 protein interactions in specific cases.|comment:"Insulin decreased GLUT4 interactions with the following proteins: Q9ER30 (Sarcosin), P09527 (Rab-7), O88960 (N-ethylmaleimide sensitive), P09456 (PKA I regulatory subunit), P27881 (Hexokinase type II), P07872 (Acyl-coenzyme A oxidase), Q6DGF1 (Isocitrate dehydrogenase), Q9EQX9 (Ubiquitin-conjugating), Q63446 (Polyubiquitin), P24268 (Cathepsin D), Q91XW0 (Heat shock protein 86), Q5FVH0 (unknown), P58405 (Striatin 3), Q62667 (Major vault protein), Q66H50 (unknown), Q09167 (splicing factor), Q9JHU5 (Arfaptin 1)."|comment:"Insulin increased GLUT4 interaction with the following proteins:Q9Z1P2 (R-actinin-1), P45592 (Cofilin), Q9QXQ0 (R-actinin-4), P26473 (ADP-ribosylation factor), P26437 (ADP-ribosylation factor),   Q7TNP1 (Basigin 2), Q6P6R2 (Dihydrolipoamide dehydrogenase),   P04797 (GAPDH), Q63081 (Protein disulfide isomerase), P29457 (47 kDa heat shock protein), Q9R1J8 (Leprecan), O88638 (Putative eps protein),   Q64375 (Synaptonemal complex)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:NDPK - Interactions involving proteins containing InterPro domain IPR001564, Nucleoside diphosphate kinase, core.	taxid:10116(rat-l6)|taxid:10116(Rattus norvegicus)	-	2006/02/15	2021/11/30	rogid:PbFY2lfrty8yw40Jq7ShR7xfuV410116	rogid:HbGGY4bUEtG4UTtU/Py7eOaeNJg10116	intact-crc:44F3A2176D02515F|rigid:9RVm0UBcqQF4k06RGKO89Bg16Q8	false	myc tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P19357	uniprotkb:O35142	intact:EBI-915426|uniprotkb:P97900|ensembl:ENSRNOP00000023256	intact:EBI-915480	psi-mi:glut4_rat(display_long)|uniprotkb:Glucose transporter type 4, insulin-responsive(gene name synonym)|uniprotkb:Slc2a4(gene name)|psi-mi:Slc2a4(display_short)|uniprotkb:Glut4(gene name synonym)	psi-mi:copb2_rat(display_long)|uniprotkb:Beta'-coat protein(gene name synonym)|uniprotkb:p102(gene name synonym)|uniprotkb:Copb2(gene name)|psi-mi:Copb2(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Foster et al. (2006)	pubmed:16396496|mint:MINT-5218203	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-921030	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2711|refseq:NP_036883.1|refseq:XP_006246658.1|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007611"(learning or memory)|go:"GO:0007614"(short-term memory)|go:"GO:0007616"(long-term memory)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010021"(amylopectin biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031550"(positive regulation of brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044381"(glucose import in response to insulin stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046323"(glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0098694"(regulation of synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0098793"(presynapse)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002441("Glucose transporter, type 4 (GLUT4)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-189200|ensembl:ENSRNOG00000017226(gene)|ensembl:ENSRNOT00000023256(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)	rgd:628746|refseq:NP_068533.1|interpro:IPR016453(Coatomer, beta' subunit)|interpro:IPR006692(Coatomer, WD associated region)|interpro:IPR020472|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR001680(WD40 repeat)|interpro:IPR036322|go:"GO:0000139"(Golgi membrane)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006888"(endoplasmic reticulum to Golgi vesicle-mediated transport)|go:"GO:0006890"(retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum)|go:"GO:0006891"(intra-Golgi vesicle-mediated transport)|go:"GO:0030126"(COPI vesicle coat)|go:"GO:1901998"(toxin transport)	-	-	-	caution:"The participant EBI-349571(P68370) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919386(Q7TP47) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920972(Q5XIP9) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-916419(P11980) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919578(Q8R491) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920554(Q5U3Z7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920647(Q5U2X8) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920585(Q7TP24) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-779677(P05426) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-915744(P02454) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|agonist:Insulin was shown to increase or decrease GLUT4 protein interactions in specific cases.|comment:"Insulin decreased GLUT4 interactions with the following proteins: Q9ER30 (Sarcosin), P09527 (Rab-7), O88960 (N-ethylmaleimide sensitive), P09456 (PKA I regulatory subunit), P27881 (Hexokinase type II), P07872 (Acyl-coenzyme A oxidase), Q6DGF1 (Isocitrate dehydrogenase), Q9EQX9 (Ubiquitin-conjugating), Q63446 (Polyubiquitin), P24268 (Cathepsin D), Q91XW0 (Heat shock protein 86), Q5FVH0 (unknown), P58405 (Striatin 3), Q62667 (Major vault protein), Q66H50 (unknown), Q09167 (splicing factor), Q9JHU5 (Arfaptin 1)."|comment:"Insulin increased GLUT4 interaction with the following proteins:Q9Z1P2 (R-actinin-1), P45592 (Cofilin), Q9QXQ0 (R-actinin-4), P26473 (ADP-ribosylation factor), P26437 (ADP-ribosylation factor),   Q7TNP1 (Basigin 2), Q6P6R2 (Dihydrolipoamide dehydrogenase),   P04797 (GAPDH), Q63081 (Protein disulfide isomerase), P29457 (47 kDa heat shock protein), Q9R1J8 (Leprecan), O88638 (Putative eps protein),   Q64375 (Synaptonemal complex)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:NDPK - Interactions involving proteins containing InterPro domain IPR001564, Nucleoside diphosphate kinase, core.	taxid:10116(rat-l6)|taxid:10116(Rattus norvegicus)	-	2006/02/15	2021/11/30	rogid:PbFY2lfrty8yw40Jq7ShR7xfuV410116	rogid:PQ0af/fKDV+v704zYQWe3qsoXt810116	intact-crc:44F3A2176D02515F|rigid:9RVm0UBcqQF4k06RGKO89Bg16Q8	false	myc tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P19357	uniprotkb:O35094	intact:EBI-915426|uniprotkb:P97900|ensembl:ENSRNOP00000023256	intact:EBI-915469	psi-mi:glut4_rat(display_long)|uniprotkb:Glucose transporter type 4, insulin-responsive(gene name synonym)|uniprotkb:Slc2a4(gene name)|psi-mi:Slc2a4(display_short)|uniprotkb:Glut4(gene name synonym)	psi-mi:tim44_rat(display_long)|uniprotkb:Timm44(gene name)|psi-mi:Timm44(display_short)|uniprotkb:Mimt44(gene name synonym)|uniprotkb:Tim44(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Foster et al. (2006)	pubmed:16396496|mint:MINT-5218203	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-921030	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2711|refseq:NP_036883.1|refseq:XP_006246658.1|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007611"(learning or memory)|go:"GO:0007614"(short-term memory)|go:"GO:0007616"(long-term memory)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010021"(amylopectin biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031550"(positive regulation of brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044381"(glucose import in response to insulin stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046323"(glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0098694"(regulation of synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0098793"(presynapse)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002441("Glucose transporter, type 4 (GLUT4)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-189200|ensembl:ENSRNOG00000017226(gene)|ensembl:ENSRNOT00000023256(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)	rgd:3864|refseq:NP_058963.1|interpro:IPR017303(Import inner membrane translocase, TIM44 subunit, mitochondria)|interpro:IPR007379(Mitochondrial import inner membrane translocase, subunit Tim44)|interpro:IPR032710|interpro:IPR039544|go:"GO:0005524"(ATP binding)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0030150"(protein import into mitochondrial matrix)|go:"GO:0051087"(chaperone binding)|go:"GO:0055007"(cardiac muscle cell differentiation)|go:"GO:1905242"(response to 3,3',5-triiodo-L-thyronine)	-	-	-	caution:"The participant EBI-349571(P68370) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919386(Q7TP47) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920972(Q5XIP9) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-916419(P11980) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919578(Q8R491) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920554(Q5U3Z7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920647(Q5U2X8) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920585(Q7TP24) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-779677(P05426) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-915744(P02454) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|agonist:Insulin was shown to increase or decrease GLUT4 protein interactions in specific cases.|comment:"Insulin decreased GLUT4 interactions with the following proteins: Q9ER30 (Sarcosin), P09527 (Rab-7), O88960 (N-ethylmaleimide sensitive), P09456 (PKA I regulatory subunit), P27881 (Hexokinase type II), P07872 (Acyl-coenzyme A oxidase), Q6DGF1 (Isocitrate dehydrogenase), Q9EQX9 (Ubiquitin-conjugating), Q63446 (Polyubiquitin), P24268 (Cathepsin D), Q91XW0 (Heat shock protein 86), Q5FVH0 (unknown), P58405 (Striatin 3), Q62667 (Major vault protein), Q66H50 (unknown), Q09167 (splicing factor), Q9JHU5 (Arfaptin 1)."|comment:"Insulin increased GLUT4 interaction with the following proteins:Q9Z1P2 (R-actinin-1), P45592 (Cofilin), Q9QXQ0 (R-actinin-4), P26473 (ADP-ribosylation factor), P26437 (ADP-ribosylation factor),   Q7TNP1 (Basigin 2), Q6P6R2 (Dihydrolipoamide dehydrogenase),   P04797 (GAPDH), Q63081 (Protein disulfide isomerase), P29457 (47 kDa heat shock protein), Q9R1J8 (Leprecan), O88638 (Putative eps protein),   Q64375 (Synaptonemal complex)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:NDPK - Interactions involving proteins containing InterPro domain IPR001564, Nucleoside diphosphate kinase, core.	taxid:10116(rat-l6)|taxid:10116(Rattus norvegicus)	-	2006/02/15	2021/11/30	rogid:PbFY2lfrty8yw40Jq7ShR7xfuV410116	rogid:DdHRFZPGeAjPu43k6MUy9W2SJEg10116	intact-crc:44F3A2176D02515F|rigid:9RVm0UBcqQF4k06RGKO89Bg16Q8	false	myc tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P19357	uniprotkb:O08839	intact:EBI-915426|uniprotkb:P97900|ensembl:ENSRNOP00000023256	intact:EBI-80095	psi-mi:glut4_rat(display_long)|uniprotkb:Glucose transporter type 4, insulin-responsive(gene name synonym)|uniprotkb:Slc2a4(gene name)|psi-mi:Slc2a4(display_short)|uniprotkb:Glut4(gene name synonym)	psi-mi:bin1_rat(display_long)|uniprotkb:Bin1(gene name)|psi-mi:Bin1(display_short)|uniprotkb:Amph2(gene name synonym)|uniprotkb:Amphl(gene name synonym)|uniprotkb:Bridging integrator 1(gene name synonym)|uniprotkb:Amphiphysin-like protein(gene name synonym)|uniprotkb:Amphiphysin II(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Foster et al. (2006)	pubmed:16396496|mint:MINT-5218203	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-921030	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2711|refseq:NP_036883.1|refseq:XP_006246658.1|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007611"(learning or memory)|go:"GO:0007614"(short-term memory)|go:"GO:0007616"(long-term memory)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010021"(amylopectin biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031550"(positive regulation of brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044381"(glucose import in response to insulin stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046323"(glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0098694"(regulation of synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0098793"(presynapse)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002441("Glucose transporter, type 4 (GLUT4)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-189200|ensembl:ENSRNOG00000017226(gene)|ensembl:ENSRNOT00000023256(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)	go:"GO:0002020"(protease binding)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005634"(nucleus)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005768"(endosome)|go:"GO:0005874"(microtubule)|go:"GO:0005886"(plasma membrane)|go:"GO:0006997"(nucleus organization)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008333"(endosome to lysosome transport)|go:"GO:0016020"(membrane)|go:"GO:0019828"(aspartic-type endopeptidase inhibitor activity)|go:"GO:0030018"(Z disc)|go:"GO:0030315"(T-tubule)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0031674"(I band)|go:"GO:0031982"(vesicle)|go:"GO:0033268"(node of Ranvier)|go:"GO:0033292"(T-tubule organization)|go:"GO:0042692"(muscle cell differentiation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043194"(axon initial segment)|go:"GO:0043196"(varicosity)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0043679"(axon terminus)|go:"GO:0044300"(cerebellar mossy fiber)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045664"(regulation of neuron differentiation)|go:"GO:0045807"(positive regulation of endocytosis)|go:"GO:0048156"(tau protein binding)|go:"GO:0048488"(synaptic vesicle endocytosis)|go:"GO:0048711"(positive regulation of astrocyte differentiation)|go:"GO:0051015"(actin filament binding)|go:"GO:0051020"(GTPase binding)|go:"GO:0051087"(chaperone binding)|go:"GO:0051647"(nucleus localization)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0060987"(lipid tube)|go:"GO:0060988"(lipid tube assembly)|go:"GO:0070063"(RNA polymerase binding)|go:"GO:0086091"(regulation of heart rate by cardiac conduction)|go:"GO:0098850"(extrinsic component of synaptic vesicle membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1901380"(negative regulation of potassium ion transmembrane transport)|go:"GO:1902430"(negative regulation of amyloid-beta formation)|go:"GO:1902960"(negative regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process)|go:"GO:1904878"(negative regulation of calcium ion transmembrane transport via high voltage-gated calcium channel)|interpro:IPR001452(Src homology-3)|interpro:IPR003005(Amphiphysin)|interpro:IPR003023(Amphiphysin, isoform 2)|interpro:IPR004148(BAR)|interpro:IPR027267|interpro:IPR035471|interpro:IPR036028|rcsb pdb:1BB9|reactome:R-RNO-8856828|go:"GO:1903946"(negative regulation of ventricular cardiac muscle cell action potential)|rgd:621786|refseq:NP_446411.1|mint:O08839|dip:DIP-30979N	-	-	-	caution:"The participant EBI-349571(P68370) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919386(Q7TP47) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920972(Q5XIP9) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-916419(P11980) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919578(Q8R491) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920554(Q5U3Z7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920647(Q5U2X8) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920585(Q7TP24) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-779677(P05426) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-915744(P02454) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|agonist:Insulin was shown to increase or decrease GLUT4 protein interactions in specific cases.|comment:"Insulin decreased GLUT4 interactions with the following proteins: Q9ER30 (Sarcosin), P09527 (Rab-7), O88960 (N-ethylmaleimide sensitive), P09456 (PKA I regulatory subunit), P27881 (Hexokinase type II), P07872 (Acyl-coenzyme A oxidase), Q6DGF1 (Isocitrate dehydrogenase), Q9EQX9 (Ubiquitin-conjugating), Q63446 (Polyubiquitin), P24268 (Cathepsin D), Q91XW0 (Heat shock protein 86), Q5FVH0 (unknown), P58405 (Striatin 3), Q62667 (Major vault protein), Q66H50 (unknown), Q09167 (splicing factor), Q9JHU5 (Arfaptin 1)."|comment:"Insulin increased GLUT4 interaction with the following proteins:Q9Z1P2 (R-actinin-1), P45592 (Cofilin), Q9QXQ0 (R-actinin-4), P26473 (ADP-ribosylation factor), P26437 (ADP-ribosylation factor),   Q7TNP1 (Basigin 2), Q6P6R2 (Dihydrolipoamide dehydrogenase),   P04797 (GAPDH), Q63081 (Protein disulfide isomerase), P29457 (47 kDa heat shock protein), Q9R1J8 (Leprecan), O88638 (Putative eps protein),   Q64375 (Synaptonemal complex)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:NDPK - Interactions involving proteins containing InterPro domain IPR001564, Nucleoside diphosphate kinase, core.	taxid:10116(rat-l6)|taxid:10116(Rattus norvegicus)	-	2006/02/15	2021/11/30	rogid:PbFY2lfrty8yw40Jq7ShR7xfuV410116	rogid:xqcXQWo+FXHjCGGI0Q9agaz9LMk10116	intact-crc:44F3A2176D02515F|rigid:9RVm0UBcqQF4k06RGKO89Bg16Q8	false	myc tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P19357	uniprotkb:O08772	intact:EBI-915426|uniprotkb:P97900|ensembl:ENSRNOP00000023256	intact:EBI-915459	psi-mi:glut4_rat(display_long)|uniprotkb:Glucose transporter type 4, insulin-responsive(gene name synonym)|uniprotkb:Slc2a4(gene name)|psi-mi:Slc2a4(display_short)|uniprotkb:Glut4(gene name synonym)	psi-mi:o08772_rat(display_long)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Foster et al. (2006)	pubmed:16396496|mint:MINT-5218203	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-921030	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2711|refseq:NP_036883.1|refseq:XP_006246658.1|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007611"(learning or memory)|go:"GO:0007614"(short-term memory)|go:"GO:0007616"(long-term memory)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010021"(amylopectin biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031550"(positive regulation of brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044381"(glucose import in response to insulin stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046323"(glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0098694"(regulation of synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0098793"(presynapse)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002441("Glucose transporter, type 4 (GLUT4)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-189200|ensembl:ENSRNOG00000017226(gene)|ensembl:ENSRNOT00000023256(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)	interpro:IPR027417|go:"GO:0003743"(translation initiation factor activity)	-	-	-	caution:"The participant EBI-349571(P68370) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919386(Q7TP47) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920972(Q5XIP9) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-916419(P11980) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919578(Q8R491) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920554(Q5U3Z7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920647(Q5U2X8) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920585(Q7TP24) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-779677(P05426) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-915744(P02454) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|agonist:Insulin was shown to increase or decrease GLUT4 protein interactions in specific cases.|comment:"Insulin decreased GLUT4 interactions with the following proteins: Q9ER30 (Sarcosin), P09527 (Rab-7), O88960 (N-ethylmaleimide sensitive), P09456 (PKA I regulatory subunit), P27881 (Hexokinase type II), P07872 (Acyl-coenzyme A oxidase), Q6DGF1 (Isocitrate dehydrogenase), Q9EQX9 (Ubiquitin-conjugating), Q63446 (Polyubiquitin), P24268 (Cathepsin D), Q91XW0 (Heat shock protein 86), Q5FVH0 (unknown), P58405 (Striatin 3), Q62667 (Major vault protein), Q66H50 (unknown), Q09167 (splicing factor), Q9JHU5 (Arfaptin 1)."|comment:"Insulin increased GLUT4 interaction with the following proteins:Q9Z1P2 (R-actinin-1), P45592 (Cofilin), Q9QXQ0 (R-actinin-4), P26473 (ADP-ribosylation factor), P26437 (ADP-ribosylation factor),   Q7TNP1 (Basigin 2), Q6P6R2 (Dihydrolipoamide dehydrogenase),   P04797 (GAPDH), Q63081 (Protein disulfide isomerase), P29457 (47 kDa heat shock protein), Q9R1J8 (Leprecan), O88638 (Putative eps protein),   Q64375 (Synaptonemal complex)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:NDPK - Interactions involving proteins containing InterPro domain IPR001564, Nucleoside diphosphate kinase, core.	taxid:10116(rat-l6)|taxid:10116(Rattus norvegicus)	-	2006/02/15	2021/11/30	rogid:PbFY2lfrty8yw40Jq7ShR7xfuV410116	rogid:/q4LkFyeJzC8aOCfCXyo7EMoO6M10116	intact-crc:44F3A2176D02515F|rigid:9RVm0UBcqQF4k06RGKO89Bg16Q8	false	myc tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P19357	uniprotkb:O08651	intact:EBI-915426|uniprotkb:P97900|ensembl:ENSRNOP00000023256	intact:EBI-915450|uniprotkb:Q546Q9|ensembl:ENSRNOP00000053019	psi-mi:glut4_rat(display_long)|uniprotkb:Glucose transporter type 4, insulin-responsive(gene name synonym)|uniprotkb:Slc2a4(gene name)|psi-mi:Slc2a4(display_short)|uniprotkb:Glut4(gene name synonym)	psi-mi:sera_rat(display_long)|uniprotkb:Phgdh(gene name)|psi-mi:Phgdh(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Foster et al. (2006)	pubmed:16396496|mint:MINT-5218203	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-921030	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2711|refseq:NP_036883.1|refseq:XP_006246658.1|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007611"(learning or memory)|go:"GO:0007614"(short-term memory)|go:"GO:0007616"(long-term memory)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010021"(amylopectin biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031550"(positive regulation of brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044381"(glucose import in response to insulin stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046323"(glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0098694"(regulation of synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0098793"(presynapse)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002441("Glucose transporter, type 4 (GLUT4)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-189200|ensembl:ENSRNOG00000017226(gene)|ensembl:ENSRNOT00000023256(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)	rgd:61987|refseq:NP_113808.1|refseq:XP_006233072.1|ensembl:ENSRNOG00000019328(gene)|ensembl:ENSRNOT00000056173(transcript)|go:"GO:0004617"(phosphoglycerate dehydrogenase activity)|go:"GO:0006541"(glutamine metabolic process)|go:"GO:0006544"(glycine metabolic process)|go:"GO:0006563"(L-serine metabolic process)|go:"GO:0006564"(L-serine biosynthetic process)|go:"GO:0006566"(threonine metabolic process)|go:"GO:0009070"(serine family amino acid biosynthetic process)|go:"GO:0009448"(gamma-aminobutyric acid metabolic process)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0019530"(taurine metabolic process)|go:"GO:0021510"(spinal cord development)|go:"GO:0021782"(glial cell development)|go:"GO:0021915"(neural tube development)|go:"GO:0022008"(neurogenesis)|go:"GO:0031175"(neuron projection development)|go:"GO:0051287"(NAD binding)|go:"GO:0070314"(G1 to G0 transition)|interpro:IPR006139(D-isomer specific 2-hydroxyacid dehydrogenase, catalytic region)|interpro:IPR006140(D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding)|interpro:IPR006236(D-3-phosphoglycerate dehydrogenase)|interpro:IPR029009|interpro:IPR029752|interpro:IPR029753|interpro:IPR036291|mint:O08651|reactome:R-RNO-977347	-	-	-	caution:"The participant EBI-349571(P68370) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919386(Q7TP47) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920972(Q5XIP9) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-916419(P11980) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919578(Q8R491) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920554(Q5U3Z7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920647(Q5U2X8) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920585(Q7TP24) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-779677(P05426) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-915744(P02454) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|agonist:Insulin was shown to increase or decrease GLUT4 protein interactions in specific cases.|comment:"Insulin decreased GLUT4 interactions with the following proteins: Q9ER30 (Sarcosin), P09527 (Rab-7), O88960 (N-ethylmaleimide sensitive), P09456 (PKA I regulatory subunit), P27881 (Hexokinase type II), P07872 (Acyl-coenzyme A oxidase), Q6DGF1 (Isocitrate dehydrogenase), Q9EQX9 (Ubiquitin-conjugating), Q63446 (Polyubiquitin), P24268 (Cathepsin D), Q91XW0 (Heat shock protein 86), Q5FVH0 (unknown), P58405 (Striatin 3), Q62667 (Major vault protein), Q66H50 (unknown), Q09167 (splicing factor), Q9JHU5 (Arfaptin 1)."|comment:"Insulin increased GLUT4 interaction with the following proteins:Q9Z1P2 (R-actinin-1), P45592 (Cofilin), Q9QXQ0 (R-actinin-4), P26473 (ADP-ribosylation factor), P26437 (ADP-ribosylation factor),   Q7TNP1 (Basigin 2), Q6P6R2 (Dihydrolipoamide dehydrogenase),   P04797 (GAPDH), Q63081 (Protein disulfide isomerase), P29457 (47 kDa heat shock protein), Q9R1J8 (Leprecan), O88638 (Putative eps protein),   Q64375 (Synaptonemal complex)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:NDPK - Interactions involving proteins containing InterPro domain IPR001564, Nucleoside diphosphate kinase, core.	taxid:10116(rat-l6)|taxid:10116(Rattus norvegicus)	-	2006/02/15	2021/11/30	rogid:PbFY2lfrty8yw40Jq7ShR7xfuV410116	rogid:HxRSndxyMrzoSms31Sg/CpNk5eU10116	intact-crc:44F3A2176D02515F|rigid:9RVm0UBcqQF4k06RGKO89Bg16Q8	false	myc tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P19357	uniprotkb:O08618	intact:EBI-915426|uniprotkb:P97900|ensembl:ENSRNOP00000023256	intact:EBI-915443|ensembl:ENSRNOP00000003697	psi-mi:glut4_rat(display_long)|uniprotkb:Glucose transporter type 4, insulin-responsive(gene name synonym)|uniprotkb:Slc2a4(gene name)|psi-mi:Slc2a4(display_short)|uniprotkb:Glut4(gene name synonym)	psi-mi:kprb_rat(display_long)|uniprotkb:41 kDa phosphoribosypyrophosphate synthetase-associated protein(gene name synonym)|uniprotkb:Prpsap2(gene name)|psi-mi:Prpsap2(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Foster et al. (2006)	pubmed:16396496|mint:MINT-5218203	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-921030	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2711|refseq:NP_036883.1|refseq:XP_006246658.1|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007611"(learning or memory)|go:"GO:0007614"(short-term memory)|go:"GO:0007616"(long-term memory)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010021"(amylopectin biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031550"(positive regulation of brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044381"(glucose import in response to insulin stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046323"(glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0098694"(regulation of synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0098793"(presynapse)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002441("Glucose transporter, type 4 (GLUT4)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-189200|ensembl:ENSRNOG00000017226(gene)|ensembl:ENSRNOT00000023256(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)	rgd:620207|refseq:NP_476472.1|refseq:XP_006246496.1|refseq:XP_006246497.1|refseq:XP_006246498.1|refseq:XP_006246499.1|refseq:XP_006246500.1|ensembl:ENSRNOG00000002724(gene)|ensembl:ENSRNOT00000003697(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0002189"(ribose phosphate diphosphokinase complex)|go:"GO:0004749"(ribose phosphate diphosphokinase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0006015"(5-phosphoribose 1-diphosphate biosynthetic process)|go:"GO:0006164"(purine nucleotide biosynthetic process)|go:"GO:0009116"(nucleoside metabolic process)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042802"(identical protein binding)|go:"GO:0060348"(bone development)|interpro:IPR000836(Phosphoribosyltransferase)|interpro:IPR005946(Phosphoribosyl pyrophosphokinase)|interpro:IPR029057|interpro:IPR029099	-	-	-	caution:"The participant EBI-349571(P68370) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919386(Q7TP47) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920972(Q5XIP9) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-916419(P11980) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919578(Q8R491) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920554(Q5U3Z7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920647(Q5U2X8) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920585(Q7TP24) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-779677(P05426) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-915744(P02454) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|agonist:Insulin was shown to increase or decrease GLUT4 protein interactions in specific cases.|comment:"Insulin decreased GLUT4 interactions with the following proteins: Q9ER30 (Sarcosin), P09527 (Rab-7), O88960 (N-ethylmaleimide sensitive), P09456 (PKA I regulatory subunit), P27881 (Hexokinase type II), P07872 (Acyl-coenzyme A oxidase), Q6DGF1 (Isocitrate dehydrogenase), Q9EQX9 (Ubiquitin-conjugating), Q63446 (Polyubiquitin), P24268 (Cathepsin D), Q91XW0 (Heat shock protein 86), Q5FVH0 (unknown), P58405 (Striatin 3), Q62667 (Major vault protein), Q66H50 (unknown), Q09167 (splicing factor), Q9JHU5 (Arfaptin 1)."|comment:"Insulin increased GLUT4 interaction with the following proteins:Q9Z1P2 (R-actinin-1), P45592 (Cofilin), Q9QXQ0 (R-actinin-4), P26473 (ADP-ribosylation factor), P26437 (ADP-ribosylation factor),   Q7TNP1 (Basigin 2), Q6P6R2 (Dihydrolipoamide dehydrogenase),   P04797 (GAPDH), Q63081 (Protein disulfide isomerase), P29457 (47 kDa heat shock protein), Q9R1J8 (Leprecan), O88638 (Putative eps protein),   Q64375 (Synaptonemal complex)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:NDPK - Interactions involving proteins containing InterPro domain IPR001564, Nucleoside diphosphate kinase, core.	taxid:10116(rat-l6)|taxid:10116(Rattus norvegicus)	-	2006/02/15	2021/11/30	rogid:PbFY2lfrty8yw40Jq7ShR7xfuV410116	rogid:lEmZQOUjl/oJRE8o750fk6sgLoI10116	intact-crc:44F3A2176D02515F|rigid:9RVm0UBcqQF4k06RGKO89Bg16Q8	false	myc tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P19357	uniprotkb:P19234	intact:EBI-915426|uniprotkb:P97900|ensembl:ENSRNOP00000023256	intact:EBI-916768|uniprotkb:Q6PDU9|ensembl:ENSRNOP00000016965	psi-mi:glut4_rat(display_long)|uniprotkb:Glucose transporter type 4, insulin-responsive(gene name synonym)|uniprotkb:Slc2a4(gene name)|psi-mi:Slc2a4(display_short)|uniprotkb:Glut4(gene name synonym)	psi-mi:nduv2_rat(display_long)|uniprotkb:NADH-ubiquinone oxidoreductase 24 kDa subunit(gene name synonym)|uniprotkb:Ndufv2(gene name)|psi-mi:Ndufv2(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Foster et al. (2006)	pubmed:16396496|mint:MINT-5218203	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-921030	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2711|refseq:NP_036883.1|refseq:XP_006246658.1|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007611"(learning or memory)|go:"GO:0007614"(short-term memory)|go:"GO:0007616"(long-term memory)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010021"(amylopectin biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031550"(positive regulation of brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044381"(glucose import in response to insulin stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046323"(glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0098694"(regulation of synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0098793"(presynapse)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002441("Glucose transporter, type 4 (GLUT4)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-189200|ensembl:ENSRNOG00000017226(gene)|ensembl:ENSRNOT00000023256(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)	rgd:621733|refseq:NP_112326.1|ensembl:ENSRNOG00000042503(gene)|ensembl:ENSRNOT00000016965(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005747"(mitochondrial respiratory chain complex I)|go:"GO:0005829"(cytosol)|go:"GO:0006120"(mitochondrial electron transport, NADH to ubiquinone)|go:"GO:0007399"(nervous system development)|go:"GO:0008137"("NADH dehydrogenase (ubiquinone) activity")|go:"GO:0046872"(metal ion binding)|go:"GO:0048738"(cardiac muscle tissue development)|go:"GO:0051537"(2 iron, 2 sulfur cluster binding)|interpro:IPR002023("NADH dehydrogenase (ubiquinone), 24 kDa subunit")|interpro:IPR036249|interpro:IPR041921|interpro:IPR042128|mint:P19234|reactome:R-RNO-611105|reactome:R-RNO-6799198	-	-	-	caution:"The participant EBI-349571(P68370) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919386(Q7TP47) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920972(Q5XIP9) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-916419(P11980) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919578(Q8R491) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920554(Q5U3Z7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920647(Q5U2X8) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920585(Q7TP24) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-779677(P05426) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-915744(P02454) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|agonist:Insulin was shown to increase or decrease GLUT4 protein interactions in specific cases.|comment:"Insulin decreased GLUT4 interactions with the following proteins: Q9ER30 (Sarcosin), P09527 (Rab-7), O88960 (N-ethylmaleimide sensitive), P09456 (PKA I regulatory subunit), P27881 (Hexokinase type II), P07872 (Acyl-coenzyme A oxidase), Q6DGF1 (Isocitrate dehydrogenase), Q9EQX9 (Ubiquitin-conjugating), Q63446 (Polyubiquitin), P24268 (Cathepsin D), Q91XW0 (Heat shock protein 86), Q5FVH0 (unknown), P58405 (Striatin 3), Q62667 (Major vault protein), Q66H50 (unknown), Q09167 (splicing factor), Q9JHU5 (Arfaptin 1)."|comment:"Insulin increased GLUT4 interaction with the following proteins:Q9Z1P2 (R-actinin-1), P45592 (Cofilin), Q9QXQ0 (R-actinin-4), P26473 (ADP-ribosylation factor), P26437 (ADP-ribosylation factor),   Q7TNP1 (Basigin 2), Q6P6R2 (Dihydrolipoamide dehydrogenase),   P04797 (GAPDH), Q63081 (Protein disulfide isomerase), P29457 (47 kDa heat shock protein), Q9R1J8 (Leprecan), O88638 (Putative eps protein),   Q64375 (Synaptonemal complex)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:NDPK - Interactions involving proteins containing InterPro domain IPR001564, Nucleoside diphosphate kinase, core.	taxid:10116(rat-l6)|taxid:10116(Rattus norvegicus)	-	2006/02/15	2021/11/30	rogid:PbFY2lfrty8yw40Jq7ShR7xfuV410116	rogid:DJh8LBV775oK8nsimzcy05KUBRg10116	intact-crc:44F3A2176D02515F|rigid:9RVm0UBcqQF4k06RGKO89Bg16Q8	false	myc tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P19357	uniprotkb:P06685	intact:EBI-915426|uniprotkb:P97900|ensembl:ENSRNOP00000023256	intact:EBI-915951|uniprotkb:Q64609|ensembl:ENSRNOP00000045650	psi-mi:glut4_rat(display_long)|uniprotkb:Glucose transporter type 4, insulin-responsive(gene name synonym)|uniprotkb:Slc2a4(gene name)|psi-mi:Slc2a4(display_short)|uniprotkb:Glut4(gene name synonym)	psi-mi:at1a1_rat(display_long)|uniprotkb:Atp1a1(gene name)|psi-mi:Atp1a1(display_short)|uniprotkb:Sodium pump subunit alpha-1(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Foster et al. (2006)	pubmed:16396496|mint:MINT-5218203	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-921030	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2711|refseq:NP_036883.1|refseq:XP_006246658.1|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007611"(learning or memory)|go:"GO:0007614"(short-term memory)|go:"GO:0007616"(long-term memory)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010021"(amylopectin biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031550"(positive regulation of brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044381"(glucose import in response to insulin stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046323"(glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0098694"(regulation of synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0098793"(presynapse)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002441("Glucose transporter, type 4 (GLUT4)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-189200|ensembl:ENSRNOG00000017226(gene)|ensembl:ENSRNOT00000023256(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)	rgd:2167|refseq:NP_036636.1|ensembl:ENSRNOG00000030019(gene)|ensembl:ENSRNOT00000040430(transcript)|go:"GO:0002026"(regulation of the force of heart contraction)|go:"GO:0002028"(regulation of sodium ion transport)|go:"GO:0005391"("P-type sodium:potassium-exchanging transporter activity")|go:"GO:0005524"(ATP binding)|go:"GO:0005768"(endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005890"("sodium:potassium-exchanging ATPase complex")|go:"GO:0005901"(caveola)|go:"GO:0006813"(potassium ion transport)|go:"GO:0006814"(sodium ion transport)|go:"GO:0006883"(cellular sodium ion homeostasis)|go:"GO:0008217"(regulation of blood pressure)|go:"GO:0010248"(establishment or maintenance of transmembrane electrochemical gradient)|go:"GO:0014069"(postsynaptic density)|go:"GO:0014704"(intercalated disc)|go:"GO:0015988"(energy coupled proton transmembrane transport, against electrochemical gradient)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016328"(lateral plasma membrane)|go:"GO:0016791"(phosphatase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030007"(cellular potassium ion homeostasis)|go:"GO:0030315"(T-tubule)|go:"GO:0030424"(axon)|go:"GO:0030506"(ankyrin binding)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031090"(organelle membrane)|go:"GO:0031402"(sodium ion binding)|go:"GO:0031947"(negative regulation of glucocorticoid biosynthetic process)|go:"GO:0032991"(protein-containing complex)|go:"GO:0036126"(sperm flagellum)|go:"GO:0036376"(sodium ion export across plasma membrane)|go:"GO:0042383"(sarcolemma)|go:"GO:0042470"(melanosome)|go:"GO:0042493"|go:"GO:0043531"(ADP binding)|go:"GO:0043548"(phosphatidylinositol 3-kinase binding)|go:"GO:0045121"(membrane raft)|go:"GO:0045822"(negative regulation of heart contraction)|go:"GO:0045823"(positive regulation of heart contraction)|go:"GO:0045989"(positive regulation of striated muscle contraction)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051087"(chaperone binding)|go:"GO:0055085"(transmembrane transport)|go:"GO:0055119"(relaxation of cardiac muscle)|go:"GO:0060048"(cardiac muscle contraction)|go:"GO:0060081"(membrane hyperpolarization)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071383"(cellular response to steroid hormone stimulus)|go:"GO:0086004"(regulation of cardiac muscle cell contraction)|go:"GO:0086009"(membrane repolarization)|go:"GO:1902600"(proton transmembrane transport)|go:"GO:1903416"(response to glycoside)|go:"GO:1990239"(steroid hormone binding)|go:"GO:1990573"(potassium ion import across plasma membrane)|interpro:IPR001757(ATPase, P-type, K/Mg/Cd/Cu/Zn/Na/Ca/Na/H-transporter)|interpro:IPR004014(ATPase, P-type cation-transporter, N-terminal)|interpro:IPR005775(ATPase, P-type cation exchange, alpha subunit, eukaryotic)|interpro:IPR006068(ATPase, P-type cation-transporter, C-terminal)|interpro:IPR008250(E1-E2 ATPase-associated region)|interpro:IPR018303|interpro:IPR023214|interpro:IPR023298|interpro:IPR023299|interpro:IPR036412|interpro:IPR044492|mint:P06685|rcsb pdb:1MO7|rcsb pdb:1MO8|reactome:R-RNO-5578775|reactome:R-RNO-936837	-	-	-	caution:"The participant EBI-349571(P68370) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919386(Q7TP47) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920972(Q5XIP9) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-916419(P11980) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919578(Q8R491) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920554(Q5U3Z7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920647(Q5U2X8) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920585(Q7TP24) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-779677(P05426) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-915744(P02454) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|agonist:Insulin was shown to increase or decrease GLUT4 protein interactions in specific cases.|comment:"Insulin decreased GLUT4 interactions with the following proteins: Q9ER30 (Sarcosin), P09527 (Rab-7), O88960 (N-ethylmaleimide sensitive), P09456 (PKA I regulatory subunit), P27881 (Hexokinase type II), P07872 (Acyl-coenzyme A oxidase), Q6DGF1 (Isocitrate dehydrogenase), Q9EQX9 (Ubiquitin-conjugating), Q63446 (Polyubiquitin), P24268 (Cathepsin D), Q91XW0 (Heat shock protein 86), Q5FVH0 (unknown), P58405 (Striatin 3), Q62667 (Major vault protein), Q66H50 (unknown), Q09167 (splicing factor), Q9JHU5 (Arfaptin 1)."|comment:"Insulin increased GLUT4 interaction with the following proteins:Q9Z1P2 (R-actinin-1), P45592 (Cofilin), Q9QXQ0 (R-actinin-4), P26473 (ADP-ribosylation factor), P26437 (ADP-ribosylation factor),   Q7TNP1 (Basigin 2), Q6P6R2 (Dihydrolipoamide dehydrogenase),   P04797 (GAPDH), Q63081 (Protein disulfide isomerase), P29457 (47 kDa heat shock protein), Q9R1J8 (Leprecan), O88638 (Putative eps protein),   Q64375 (Synaptonemal complex)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:NDPK - Interactions involving proteins containing InterPro domain IPR001564, Nucleoside diphosphate kinase, core.	taxid:10116(rat-l6)|taxid:10116(Rattus norvegicus)	-	2006/02/15	2021/11/30	rogid:PbFY2lfrty8yw40Jq7ShR7xfuV410116	rogid:Chn3+kL+xhJd9yHk1JWVxqmhS4A10116	intact-crc:44F3A2176D02515F|rigid:9RVm0UBcqQF4k06RGKO89Bg16Q8	false	myc tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P19357	uniprotkb:P63039	intact:EBI-915426|uniprotkb:P97900|ensembl:ENSRNOP00000023256	intact:EBI-432091|uniprotkb:P19226|uniprotkb:P19227|uniprotkb:P97602|ensembl:ENSRNOP00000063666	psi-mi:glut4_rat(display_long)|uniprotkb:Glucose transporter type 4, insulin-responsive(gene name synonym)|uniprotkb:Slc2a4(gene name)|psi-mi:Slc2a4(display_short)|uniprotkb:Glut4(gene name synonym)	psi-mi:ch60_rat(display_long)|uniprotkb:Heat shock protein 60(gene name synonym)|uniprotkb:60 kDa chaperonin(gene name synonym)|uniprotkb:Chaperonin 60(gene name synonym)|uniprotkb:Mitochondrial matrix protein P1(gene name synonym)|uniprotkb:HSP-65(gene name synonym)|uniprotkb:Hspd1(gene name)|psi-mi:Hspd1(display_short)|uniprotkb:Hsp60(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Foster et al. (2006)	pubmed:16396496|mint:MINT-5218203	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-921030	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2711|refseq:NP_036883.1|refseq:XP_006246658.1|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007611"(learning or memory)|go:"GO:0007614"(short-term memory)|go:"GO:0007616"(long-term memory)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010021"(amylopectin biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031550"(positive regulation of brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044381"(glucose import in response to insulin stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046323"(glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0098694"(regulation of synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0098793"(presynapse)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002441("Glucose transporter, type 4 (GLUT4)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-189200|ensembl:ENSRNOG00000017226(gene)|ensembl:ENSRNOT00000023256(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)	rgd:621314|refseq:NP_071565.2|refseq:XP_006244994.1|go:"GO:0034185"(apolipoprotein binding)|go:"GO:0034186"(apolipoprotein A-I binding)|go:"GO:0034514"(mitochondrial unfolded protein response)|go:"GO:0034605"(cellular response to heat)|go:"GO:0042026"(protein refolding)|go:"GO:0042100"(B cell proliferation)|go:"GO:0042110"(T cell activation)|go:"GO:0042113"(B cell activation)|go:"GO:0042220"(response to cocaine)|go:"GO:0042493"|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0042588"(zymogen granule)|go:"GO:0043032"(positive regulation of macrophage activation)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043627"(response to estrogen)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045041"(protein import into mitochondrial intermembrane space)|go:"GO:0045121"(membrane raft)|go:"GO:0046696"(lipopolysaccharide receptor complex)|go:"GO:0048291"(isotype switching to IgG isotypes)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0050821"(protein stabilization)|go:"GO:0050870"(positive regulation of T cell activation)|go:"GO:0051087"(chaperone binding)|go:"GO:0051384"(response to glucocorticoid)|go:"GO:0051702"(biological process involved in interaction with symbiont)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071866"(negative regulation of apoptotic process in bone marrow cell)|go:"GO:0097225"(sperm midpiece)|go:"GO:0098761"(cellular response to interleukin-7)|go:"GO:0140030"(modification-dependent protein binding)|go:"GO:1903427"(negative regulation of reactive oxygen species biosynthetic process)|interpro:IPR001844(Chaperonin Cpn60)|interpro:IPR002423(Chaperonin Cpn60/TCP-1)|interpro:IPR018370|interpro:IPR027409|interpro:IPR027410|interpro:IPR027413|mint:P63039|reactome:R-RNO-1268020|ensembl:ENSRNOG00000014525(gene)|ensembl:ENSRNOT00000066589(transcript)|go:"GO:0001530"(lipopolysaccharide binding)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002039"(p53 binding)|go:"GO:0002755"(MyD88-dependent toll-like receptor signaling pathway)|go:"GO:0002842"(positive regulation of T cell mediated immune response to tumor cell)|go:"GO:0002931"(response to ischemia)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005769"(early endosome)|go:"GO:0005782"(peroxisomal matrix)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0006457"(protein folding)|go:"GO:0006458"('de novo' protein folding)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0006986"(response to unfolded protein)|go:"GO:0008035"(high-density lipoprotein particle binding)|go:"GO:0008637"(apoptotic mitochondrial changes)|go:"GO:0009408"(response to heat)|go:"GO:0009409"(response to cold)|go:"GO:0009986"(cell surface)|go:"GO:0010033"(response to organic substance)|go:"GO:0014070"(response to organic cyclic compound)|go:"GO:0014823"(response to activity)|go:"GO:0016020"(membrane)|go:"GO:0016853"(isomerase activity)|go:"GO:0019899"(enzyme binding)|go:"GO:0030061"(mitochondrial crista)|go:"GO:0030135"(coated vesicle)|go:"GO:0030141"(secretory granule)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031985"(Golgi cisterna)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032727"(positive regulation of interferon-alpha production)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0032735"(positive regulation of interleukin-12 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033198"(response to ATP)	-	-	-	caution:"The participant EBI-349571(P68370) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919386(Q7TP47) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920972(Q5XIP9) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-916419(P11980) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919578(Q8R491) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920554(Q5U3Z7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920647(Q5U2X8) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920585(Q7TP24) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-779677(P05426) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-915744(P02454) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|agonist:Insulin was shown to increase or decrease GLUT4 protein interactions in specific cases.|comment:"Insulin decreased GLUT4 interactions with the following proteins: Q9ER30 (Sarcosin), P09527 (Rab-7), O88960 (N-ethylmaleimide sensitive), P09456 (PKA I regulatory subunit), P27881 (Hexokinase type II), P07872 (Acyl-coenzyme A oxidase), Q6DGF1 (Isocitrate dehydrogenase), Q9EQX9 (Ubiquitin-conjugating), Q63446 (Polyubiquitin), P24268 (Cathepsin D), Q91XW0 (Heat shock protein 86), Q5FVH0 (unknown), P58405 (Striatin 3), Q62667 (Major vault protein), Q66H50 (unknown), Q09167 (splicing factor), Q9JHU5 (Arfaptin 1)."|comment:"Insulin increased GLUT4 interaction with the following proteins:Q9Z1P2 (R-actinin-1), P45592 (Cofilin), Q9QXQ0 (R-actinin-4), P26473 (ADP-ribosylation factor), P26437 (ADP-ribosylation factor),   Q7TNP1 (Basigin 2), Q6P6R2 (Dihydrolipoamide dehydrogenase),   P04797 (GAPDH), Q63081 (Protein disulfide isomerase), P29457 (47 kDa heat shock protein), Q9R1J8 (Leprecan), O88638 (Putative eps protein),   Q64375 (Synaptonemal complex)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:NDPK - Interactions involving proteins containing InterPro domain IPR001564, Nucleoside diphosphate kinase, core.	taxid:10116(rat-l6)|taxid:10116(Rattus norvegicus)	-	2006/02/15	2021/11/30	rogid:PbFY2lfrty8yw40Jq7ShR7xfuV410116	rogid:WD1fQLh4I0ovpakE8KtM1R0XpL410116	intact-crc:44F3A2176D02515F|rigid:9RVm0UBcqQF4k06RGKO89Bg16Q8	false	myc tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P19357	uniprotkb:P18484	intact:EBI-915426|uniprotkb:P97900|ensembl:ENSRNOP00000023256	intact:EBI-539360	psi-mi:glut4_rat(display_long)|uniprotkb:Glucose transporter type 4, insulin-responsive(gene name synonym)|uniprotkb:Slc2a4(gene name)|psi-mi:Slc2a4(display_short)|uniprotkb:Glut4(gene name synonym)	psi-mi:ap2a2_rat(display_long)|uniprotkb:Adaptor protein complex AP-2 subunit alpha-2(gene name synonym)|uniprotkb:Alpha2-adaptin(gene name synonym)|uniprotkb:Plasma membrane adaptor HA2/AP2 adaptin alpha C subunit(gene name synonym)|uniprotkb:Alpha-adaptin C(gene name synonym)|uniprotkb:Clathrin assembly protein complex 2 alpha-C large chain(gene name synonym)|uniprotkb:100 kDa coated vesicle protein C(gene name synonym)|uniprotkb:Ap2a2(gene name)|psi-mi:Ap2a2(display_short)|uniprotkb:Adtab(gene name synonym)|uniprotkb:Adaptor-related protein complex 2 subunit alpha-2(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Foster et al. (2006)	pubmed:16396496|mint:MINT-5218203	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-921030	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2711|refseq:NP_036883.1|refseq:XP_006246658.1|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007611"(learning or memory)|go:"GO:0007614"(short-term memory)|go:"GO:0007616"(long-term memory)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010021"(amylopectin biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031550"(positive regulation of brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044381"(glucose import in response to insulin stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046323"(glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0098694"(regulation of synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0098793"(presynapse)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002441("Glucose transporter, type 4 (GLUT4)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-189200|ensembl:ENSRNOG00000017226(gene)|ensembl:ENSRNOT00000023256(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)	rgd:71015|go:"GO:0005886"(plasma membrane)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006898"(receptor-mediated endocytosis)|interpro:IPR002553(Clathrin/coatomer adaptor, adaptin-like, N-terminal)|interpro:IPR003164(Clathrin adaptor, alpha-adaptin, appendage, C-terminal subdomain)|interpro:IPR008152(Clathrin adaptor, alpha/beta/gamma-adaptin, appendage, Ig-like subdomain)|interpro:IPR009028(Clathrin/coatomer adaptor, adaptin-like, appendage, C-terminal subdomain)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR012295(Beta2-adaptin/TATA-box binding, C-terminal)|interpro:IPR013041(Clathrin/coatomer adaptor, adaptin-like, appendage, Ig-like subdomain)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR017104(Adaptor protein complex AP-2, alpha subunit)|rcsb pdb:2VGL|rcsb pdb:2XA7|go:"GO:0008021"(synaptic vesicle)|rcsb pdb:4NEE|rcsb pdb:4UQI|rcsb pdb:6OWT|rcsb pdb:6QH5|rcsb pdb:6QH6|rcsb pdb:6QH7|go:"GO:0019900"(kinase binding)|rcsb pdb:6URI|rcsb pdb:6YAE|rcsb pdb:6YAF|rcsb pdb:6YAH|reactome:R-RNO-177504|reactome:R-RNO-2132295|reactome:R-RNO-416993|reactome:R-RNO-437239|reactome:R-RNO-5099900|reactome:R-RNO-5140745|reactome:R-RNO-6798695|reactome:R-RNO-8856825|go:"GO:0019901"(protein kinase binding)|reactome:R-RNO-8856828|go:"GO:0019904"(protein domain specific binding)|reactome:R-RNO-8866427|reactome:R-RNO-8964038|go:"GO:0030117"(membrane coat)|go:"GO:0030122"(AP-2 adaptor complex)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0035091"(phosphatidylinositol binding)|go:"GO:0035615"(clathrin adaptor activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0072583"(clathrin-dependent endocytosis)|go:"GO:0097718"(disordered domain specific binding)|go:"GO:0140312"(cargo adaptor activity)|mint:P18484|dip:DIP-29765N	-	-	-	caution:"The participant EBI-349571(P68370) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919386(Q7TP47) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920972(Q5XIP9) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-916419(P11980) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919578(Q8R491) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920554(Q5U3Z7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920647(Q5U2X8) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920585(Q7TP24) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-779677(P05426) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-915744(P02454) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|agonist:Insulin was shown to increase or decrease GLUT4 protein interactions in specific cases.|comment:"Insulin decreased GLUT4 interactions with the following proteins: Q9ER30 (Sarcosin), P09527 (Rab-7), O88960 (N-ethylmaleimide sensitive), P09456 (PKA I regulatory subunit), P27881 (Hexokinase type II), P07872 (Acyl-coenzyme A oxidase), Q6DGF1 (Isocitrate dehydrogenase), Q9EQX9 (Ubiquitin-conjugating), Q63446 (Polyubiquitin), P24268 (Cathepsin D), Q91XW0 (Heat shock protein 86), Q5FVH0 (unknown), P58405 (Striatin 3), Q62667 (Major vault protein), Q66H50 (unknown), Q09167 (splicing factor), Q9JHU5 (Arfaptin 1)."|comment:"Insulin increased GLUT4 interaction with the following proteins:Q9Z1P2 (R-actinin-1), P45592 (Cofilin), Q9QXQ0 (R-actinin-4), P26473 (ADP-ribosylation factor), P26437 (ADP-ribosylation factor),   Q7TNP1 (Basigin 2), Q6P6R2 (Dihydrolipoamide dehydrogenase),   P04797 (GAPDH), Q63081 (Protein disulfide isomerase), P29457 (47 kDa heat shock protein), Q9R1J8 (Leprecan), O88638 (Putative eps protein),   Q64375 (Synaptonemal complex)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:NDPK - Interactions involving proteins containing InterPro domain IPR001564, Nucleoside diphosphate kinase, core.	taxid:10116(rat-l6)|taxid:10116(Rattus norvegicus)	-	2006/02/15	2021/11/30	rogid:PbFY2lfrty8yw40Jq7ShR7xfuV410116	rogid:/3UaX0n3j6Lo0w7GMn0uWzL5GI010116	intact-crc:44F3A2176D02515F|rigid:9RVm0UBcqQF4k06RGKO89Bg16Q8	false	myc tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P19357	uniprotkb:P18421	intact:EBI-915426|uniprotkb:P97900|ensembl:ENSRNOP00000023256	intact:EBI-916762	psi-mi:glut4_rat(display_long)|uniprotkb:Glucose transporter type 4, insulin-responsive(gene name synonym)|uniprotkb:Slc2a4(gene name)|psi-mi:Slc2a4(display_short)|uniprotkb:Glut4(gene name synonym)	psi-mi:psb1_rat(display_long)|uniprotkb:Proteasome component C5(gene name synonym)|uniprotkb:Macropain subunit C5(gene name synonym)|uniprotkb:Multicatalytic endopeptidase complex subunit C5(gene name synonym)|uniprotkb:Proteasome gamma chain(gene name synonym)|uniprotkb:Psmb1(gene name)|psi-mi:Psmb1(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Foster et al. (2006)	pubmed:16396496|mint:MINT-5218203	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-921030	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2711|refseq:NP_036883.1|refseq:XP_006246658.1|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007611"(learning or memory)|go:"GO:0007614"(short-term memory)|go:"GO:0007616"(long-term memory)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010021"(amylopectin biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031550"(positive regulation of brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044381"(glucose import in response to insulin stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046323"(glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0098694"(regulation of synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0098793"(presynapse)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002441("Glucose transporter, type 4 (GLUT4)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-189200|ensembl:ENSRNOG00000017226(gene)|ensembl:ENSRNOT00000023256(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)	interpro:IPR029055|rgd:621092|refseq:NP_446042.1|interpro:IPR016050(Proteasome, beta-type subunit, conserved site)|interpro:IPR001353(20S proteasome, A and B subunits)|interpro:IPR023333|reactome:R-RNO-8932339|reactome:R-RNO-174084|reactome:R-RNO-5689603|reactome:R-RNO-5689880|reactome:R-RNO-6798695|reactome:R-RNO-68827|reactome:R-RNO-8951664|rcsb pdb:6EPC|rcsb pdb:6EPD|rcsb pdb:6EPE|rcsb pdb:6EPF|interpro:IPR035202|rcsb pdb:6TU3|reactome:R-RNO-1169091|reactome:R-RNO-1234176|reactome:R-RNO-1236978|reactome:R-RNO-174154|reactome:R-RNO-174178|reactome:R-RNO-174184|reactome:R-RNO-187577|reactome:R-RNO-195253|reactome:R-RNO-2467813|reactome:R-RNO-349425|reactome:R-RNO-350562|reactome:R-RNO-382556|reactome:R-RNO-450408|reactome:R-RNO-4608870|reactome:R-RNO-4641257|reactome:R-RNO-4641258|reactome:R-RNO-5358346|reactome:R-RNO-5607761|reactome:R-RNO-5610780|reactome:R-RNO-5610785|reactome:R-RNO-5632684|reactome:R-RNO-5658442|reactome:R-RNO-5668541|reactome:R-RNO-5676590|reactome:R-RNO-5687128|reactome:R-RNO-68949|reactome:R-RNO-69017|reactome:R-RNO-69481|reactome:R-RNO-69601|reactome:R-RNO-75815|reactome:R-RNO-8852276|reactome:R-RNO-8854050|reactome:R-RNO-8939236|reactome:R-RNO-8941858|reactome:R-RNO-8948751|reactome:R-RNO-983168|go:"GO:0000502"(proteasome complex)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004298"(threonine-type endopeptidase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005839"(proteasome core complex)|go:"GO:0010499"(proteasomal ubiquitin-independent protein catabolic process)|go:"GO:0019774"(proteasome core complex, beta-subunit complex)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)	-	-	-	caution:"The participant EBI-349571(P68370) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919386(Q7TP47) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920972(Q5XIP9) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-916419(P11980) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919578(Q8R491) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920554(Q5U3Z7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920647(Q5U2X8) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920585(Q7TP24) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-779677(P05426) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-915744(P02454) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|agonist:Insulin was shown to increase or decrease GLUT4 protein interactions in specific cases.|comment:"Insulin decreased GLUT4 interactions with the following proteins: Q9ER30 (Sarcosin), P09527 (Rab-7), O88960 (N-ethylmaleimide sensitive), P09456 (PKA I regulatory subunit), P27881 (Hexokinase type II), P07872 (Acyl-coenzyme A oxidase), Q6DGF1 (Isocitrate dehydrogenase), Q9EQX9 (Ubiquitin-conjugating), Q63446 (Polyubiquitin), P24268 (Cathepsin D), Q91XW0 (Heat shock protein 86), Q5FVH0 (unknown), P58405 (Striatin 3), Q62667 (Major vault protein), Q66H50 (unknown), Q09167 (splicing factor), Q9JHU5 (Arfaptin 1)."|comment:"Insulin increased GLUT4 interaction with the following proteins:Q9Z1P2 (R-actinin-1), P45592 (Cofilin), Q9QXQ0 (R-actinin-4), P26473 (ADP-ribosylation factor), P26437 (ADP-ribosylation factor),   Q7TNP1 (Basigin 2), Q6P6R2 (Dihydrolipoamide dehydrogenase),   P04797 (GAPDH), Q63081 (Protein disulfide isomerase), P29457 (47 kDa heat shock protein), Q9R1J8 (Leprecan), O88638 (Putative eps protein),   Q64375 (Synaptonemal complex)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:NDPK - Interactions involving proteins containing InterPro domain IPR001564, Nucleoside diphosphate kinase, core.	taxid:10116(rat-l6)|taxid:10116(Rattus norvegicus)	-	2006/02/15	2021/11/30	rogid:PbFY2lfrty8yw40Jq7ShR7xfuV410116	rogid:lkLXXyjxqUfmYPrGfPnXtXeEUP410116	intact-crc:44F3A2176D02515F|rigid:9RVm0UBcqQF4k06RGKO89Bg16Q8	false	myc tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P19357	uniprotkb:P18420	intact:EBI-915426|uniprotkb:P97900|ensembl:ENSRNOP00000023256	intact:EBI-916756|ensembl:ENSRNOP00000015946	psi-mi:glut4_rat(display_long)|uniprotkb:Glucose transporter type 4, insulin-responsive(gene name synonym)|uniprotkb:Slc2a4(gene name)|psi-mi:Slc2a4(display_short)|uniprotkb:Glut4(gene name synonym)	psi-mi:psa1_rat(display_long)|uniprotkb:Proteasome component C2(gene name synonym)|uniprotkb:Macropain subunit C2(gene name synonym)|uniprotkb:Multicatalytic endopeptidase complex subunit C2(gene name synonym)|uniprotkb:Proteasome nu chain(gene name synonym)|uniprotkb:Psma1(gene name)|psi-mi:Psma1(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Foster et al. (2006)	pubmed:16396496|mint:MINT-5218203	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-921030	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2711|refseq:NP_036883.1|refseq:XP_006246658.1|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007611"(learning or memory)|go:"GO:0007614"(short-term memory)|go:"GO:0007616"(long-term memory)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010021"(amylopectin biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031550"(positive regulation of brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044381"(glucose import in response to insulin stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046323"(glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0098694"(regulation of synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0098793"(presynapse)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002441("Glucose transporter, type 4 (GLUT4)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-189200|ensembl:ENSRNOG00000017226(gene)|ensembl:ENSRNOT00000023256(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)	rgd:61841|refseq:NP_058974.1|ensembl:ENSRNOG00000011745(gene)|ensembl:ENSRNOT00000015946(transcript)|go:"GO:0000502"(proteasome complex)|go:"GO:0001530"(lipopolysaccharide binding)|go:"GO:0002376"(immune system process)|go:"GO:0002862"(negative regulation of inflammatory response to antigenic stimulus)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005839"(proteasome core complex)|go:"GO:0010499"(proteasomal ubiquitin-independent protein catabolic process)|go:"GO:0019773"(proteasome core complex, alpha-subunit complex)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|interpro:IPR000426(Proteasome alpha-subunit, conserved site)|interpro:IPR001353(20S proteasome, A and B subunits)|interpro:IPR023332|interpro:IPR029055|interpro:IPR035144|rcsb pdb:6EPC|rcsb pdb:6EPD|rcsb pdb:6EPE|rcsb pdb:6EPF|rcsb pdb:6TU3|reactome:R-RNO-1169091|reactome:R-RNO-1234176|reactome:R-RNO-1236978|reactome:R-RNO-174084|reactome:R-RNO-174154|reactome:R-RNO-174178|reactome:R-RNO-174184|reactome:R-RNO-187577|reactome:R-RNO-195253|reactome:R-RNO-2467813|reactome:R-RNO-349425|reactome:R-RNO-350562|reactome:R-RNO-382556|reactome:R-RNO-450408|reactome:R-RNO-4608870|reactome:R-RNO-4641257|reactome:R-RNO-4641258|reactome:R-RNO-5358346|reactome:R-RNO-5607761|reactome:R-RNO-5610780|reactome:R-RNO-5610785|reactome:R-RNO-5632684|reactome:R-RNO-5658442|reactome:R-RNO-5668541|reactome:R-RNO-5676590|reactome:R-RNO-5687128|reactome:R-RNO-5689603|reactome:R-RNO-5689880|reactome:R-RNO-68827|reactome:R-RNO-68949|reactome:R-RNO-69017|reactome:R-RNO-69481|reactome:R-RNO-69601|reactome:R-RNO-75815|reactome:R-RNO-8852276|reactome:R-RNO-8854050|reactome:R-RNO-8932339|reactome:R-RNO-8939236|reactome:R-RNO-8941858|reactome:R-RNO-8948751|reactome:R-RNO-8951664|reactome:R-RNO-983168	-	-	-	caution:"The participant EBI-349571(P68370) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919386(Q7TP47) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920972(Q5XIP9) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-916419(P11980) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919578(Q8R491) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920554(Q5U3Z7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920647(Q5U2X8) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920585(Q7TP24) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-779677(P05426) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-915744(P02454) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|agonist:Insulin was shown to increase or decrease GLUT4 protein interactions in specific cases.|comment:"Insulin decreased GLUT4 interactions with the following proteins: Q9ER30 (Sarcosin), P09527 (Rab-7), O88960 (N-ethylmaleimide sensitive), P09456 (PKA I regulatory subunit), P27881 (Hexokinase type II), P07872 (Acyl-coenzyme A oxidase), Q6DGF1 (Isocitrate dehydrogenase), Q9EQX9 (Ubiquitin-conjugating), Q63446 (Polyubiquitin), P24268 (Cathepsin D), Q91XW0 (Heat shock protein 86), Q5FVH0 (unknown), P58405 (Striatin 3), Q62667 (Major vault protein), Q66H50 (unknown), Q09167 (splicing factor), Q9JHU5 (Arfaptin 1)."|comment:"Insulin increased GLUT4 interaction with the following proteins:Q9Z1P2 (R-actinin-1), P45592 (Cofilin), Q9QXQ0 (R-actinin-4), P26473 (ADP-ribosylation factor), P26437 (ADP-ribosylation factor),   Q7TNP1 (Basigin 2), Q6P6R2 (Dihydrolipoamide dehydrogenase),   P04797 (GAPDH), Q63081 (Protein disulfide isomerase), P29457 (47 kDa heat shock protein), Q9R1J8 (Leprecan), O88638 (Putative eps protein),   Q64375 (Synaptonemal complex)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:NDPK - Interactions involving proteins containing InterPro domain IPR001564, Nucleoside diphosphate kinase, core.	taxid:10116(rat-l6)|taxid:10116(Rattus norvegicus)	-	2006/02/15	2021/11/30	rogid:PbFY2lfrty8yw40Jq7ShR7xfuV410116	rogid:G3711K47dBhN7JJU+iPIkHVddpE10116	intact-crc:44F3A2176D02515F|rigid:9RVm0UBcqQF4k06RGKO89Bg16Q8	false	myc tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P19357	uniprotkb:P18418	intact:EBI-915426|uniprotkb:P97900|ensembl:ENSRNOP00000023256	intact:EBI-916742|uniprotkb:P10452|ensembl:ENSRNOP00000004091	psi-mi:glut4_rat(display_long)|uniprotkb:Glucose transporter type 4, insulin-responsive(gene name synonym)|uniprotkb:Slc2a4(gene name)|psi-mi:Slc2a4(display_short)|uniprotkb:Glut4(gene name synonym)	psi-mi:calr_rat(display_long)|uniprotkb:CRP55(gene name synonym)|uniprotkb:Calregulin(gene name synonym)|uniprotkb:HACBP(gene name synonym)|uniprotkb:Endoplasmic reticulum resident protein 60(gene name synonym)|uniprotkb:CALBP(gene name synonym)|uniprotkb:Calcium-binding protein 3(gene name synonym)|uniprotkb:Calr(gene name)|psi-mi:Calr(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Foster et al. (2006)	pubmed:16396496|mint:MINT-5218203	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-921030	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2711|refseq:NP_036883.1|refseq:XP_006246658.1|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007611"(learning or memory)|go:"GO:0007614"(short-term memory)|go:"GO:0007616"(long-term memory)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010021"(amylopectin biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031550"(positive regulation of brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044381"(glucose import in response to insulin stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046323"(glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0098694"(regulation of synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0098793"(presynapse)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002441("Glucose transporter, type 4 (GLUT4)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-189200|ensembl:ENSRNOG00000017226(gene)|ensembl:ENSRNOT00000023256(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)	rgd:620288|refseq:NP_071794.1|ensembl:ENSRNOG00000003029(gene)|ensembl:ENSRNOT00000004091(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001669"(acrosomal vesicle)|go:"GO:0002502"(peptide antigen assembly with MHC class I protein complex)|go:"GO:0003729"(mRNA binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005506"(iron ion binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005790"(smooth endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0006457"(protein folding)|go:"GO:0006611"(protein export from nucleus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010033"(response to organic substance)|go:"GO:0010595"(positive regulation of endothelial cell migration)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016020"(membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0030246"(carbohydrate binding)|go:"GO:0030866"(cortical actin cytoskeleton organization)|go:"GO:0030968"(endoplasmic reticulum unfolded protein response)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032355"(response to estradiol)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033018"(sarcoplasmic reticulum lumen)|go:"GO:0033144"(negative regulation of intracellular steroid hormone receptor signaling pathway)|go:"GO:0033574"(response to testosterone)|go:"GO:0034504"(protein localization to nucleus)|go:"GO:0040020"(regulation of meiotic nuclear division)|go:"GO:0042277"(peptide binding)|go:"GO:0042493"|go:"GO:0042562"(hormone binding)|go:"GO:0042824"(MHC class I peptide loading complex)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044322"(endoplasmic reticulum quality control compartment)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0045787"(positive regulation of cell cycle)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0048387"(negative regulation of retinoic acid receptor signaling pathway)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050681"(androgen receptor binding)|go:"GO:0050766"(positive regulation of phagocytosis)|go:"GO:0050821"(protein stabilization)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0055007"(cardiac muscle cell differentiation)|go:"GO:0060473"(cortical granule)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0071285"(cellular response to lithium ion)|go:"GO:0071310"(cellular response to organic substance)|go:"GO:0090398"(cellular senescence)|go:"GO:1900026"(positive regulation of substrate adhesion-dependent cell spreading)|go:"GO:1901164"(negative regulation of trophoblast cell migration)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:2000510"(positive regulation of dendritic cell chemotaxis)|interpro:IPR001580(Calreticulin/calnexin)|interpro:IPR009033(Calreticulin/calnexin, P)|interpro:IPR009169(Calreticulin)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR018124|mint:P18418|rcsb pdb:1HHN|rcsb pdb:1K91|rcsb pdb:1K9C|reactome:R-RNO-1236974|reactome:R-RNO-3000480|reactome:R-RNO-901042|reactome:R-RNO-983170	-	-	-	caution:"The participant EBI-349571(P68370) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919386(Q7TP47) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920972(Q5XIP9) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-916419(P11980) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919578(Q8R491) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920554(Q5U3Z7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920647(Q5U2X8) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920585(Q7TP24) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-779677(P05426) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-915744(P02454) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|agonist:Insulin was shown to increase or decrease GLUT4 protein interactions in specific cases.|comment:"Insulin decreased GLUT4 interactions with the following proteins: Q9ER30 (Sarcosin), P09527 (Rab-7), O88960 (N-ethylmaleimide sensitive), P09456 (PKA I regulatory subunit), P27881 (Hexokinase type II), P07872 (Acyl-coenzyme A oxidase), Q6DGF1 (Isocitrate dehydrogenase), Q9EQX9 (Ubiquitin-conjugating), Q63446 (Polyubiquitin), P24268 (Cathepsin D), Q91XW0 (Heat shock protein 86), Q5FVH0 (unknown), P58405 (Striatin 3), Q62667 (Major vault protein), Q66H50 (unknown), Q09167 (splicing factor), Q9JHU5 (Arfaptin 1)."|comment:"Insulin increased GLUT4 interaction with the following proteins:Q9Z1P2 (R-actinin-1), P45592 (Cofilin), Q9QXQ0 (R-actinin-4), P26473 (ADP-ribosylation factor), P26437 (ADP-ribosylation factor),   Q7TNP1 (Basigin 2), Q6P6R2 (Dihydrolipoamide dehydrogenase),   P04797 (GAPDH), Q63081 (Protein disulfide isomerase), P29457 (47 kDa heat shock protein), Q9R1J8 (Leprecan), O88638 (Putative eps protein),   Q64375 (Synaptonemal complex)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:NDPK - Interactions involving proteins containing InterPro domain IPR001564, Nucleoside diphosphate kinase, core.	taxid:10116(rat-l6)|taxid:10116(Rattus norvegicus)	-	2006/02/15	2021/11/30	rogid:PbFY2lfrty8yw40Jq7ShR7xfuV410116	rogid:mFrLbrHGBN1Bxc+erHTyfw1NwMw10116	intact-crc:44F3A2176D02515F|rigid:9RVm0UBcqQF4k06RGKO89Bg16Q8	false	myc tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P19357	uniprotkb:P18163	intact:EBI-915426|uniprotkb:P97900|ensembl:ENSRNOP00000023256	intact:EBI-916732|ensembl:ENSRNOP00000014235|ensembl:ENSRNOP00000072677	psi-mi:glut4_rat(display_long)|uniprotkb:Glucose transporter type 4, insulin-responsive(gene name synonym)|uniprotkb:Slc2a4(gene name)|psi-mi:Slc2a4(display_short)|uniprotkb:Glut4(gene name synonym)	psi-mi:acsl1_rat(display_long)|uniprotkb:Long-chain acyl-CoA synthetase 1(gene name synonym)|uniprotkb:Long-chain-fatty-acid--CoA ligase, liver isozyme(gene name synonym)|uniprotkb:Acsl1(gene name)|psi-mi:Acsl1(display_short)|uniprotkb:Acs1(gene name synonym)|uniprotkb:Acsl2(gene name synonym)|uniprotkb:Facl2(gene name synonym)|uniprotkb:Arachidonate--CoA ligase(gene name synonym)|uniprotkb:Phytanate--CoA ligase(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Foster et al. (2006)	pubmed:16396496|mint:MINT-5218203	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-921030	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2711|refseq:NP_036883.1|refseq:XP_006246658.1|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007611"(learning or memory)|go:"GO:0007614"(short-term memory)|go:"GO:0007616"(long-term memory)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010021"(amylopectin biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031550"(positive regulation of brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044381"(glucose import in response to insulin stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046323"(glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0098694"(regulation of synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0098793"(presynapse)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002441("Glucose transporter, type 4 (GLUT4)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-189200|ensembl:ENSRNOG00000017226(gene)|ensembl:ENSRNOT00000023256(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)	rgd:2015|refseq:NP_036952.1|refseq:XP_008769476.1|refseq:XP_006253184.1|refseq:XP_006253185.1|refseq:XP_006253186.1|refseq:XP_006253187.1|refseq:XP_006253188.1|refseq:XP_006253189.1|ensembl:ENSRNOG00000010633(gene)|ensembl:ENSRNOT00000014235(transcript)|ensembl:ENSRNOT00000089501(transcript)|go:"GO:0000038"(very long-chain fatty acid metabolic process)|go:"GO:0001676"(long-chain fatty acid metabolic process)|go:"GO:0003987"(acetate-CoA ligase activity)|go:"GO:0004467"(long-chain fatty acid-CoA ligase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005778"(peroxisomal membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0006631"(fatty acid metabolic process)|go:"GO:0007584"(response to nutrient)|go:"GO:0008610"(lipid biosynthetic process)|go:"GO:0010033"(response to organic substance)|go:"GO:0010747"(positive regulation of long-chain fatty acid import across plasma membrane)|go:"GO:0014070"(response to organic cyclic compound)|go:"GO:0015908"(fatty acid transport)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019432"(triglyceride biosynthetic process)|go:"GO:0033211"(adiponectin-activated signaling pathway)|go:"GO:0034201"(response to oleic acid)|go:"GO:0035338"(long-chain fatty-acyl-CoA biosynthetic process)|go:"GO:0042178"(xenobiotic catabolic process)|go:"GO:0042493"|go:"GO:0044539"(long-chain fatty acid import into cell)|go:"GO:0047676"(arachidonate-CoA ligase activity)|go:"GO:0050197"(phytanate-CoA ligase activity)|go:"GO:0070251"(pristanate-CoA ligase activity)|go:"GO:0071902"(positive regulation of protein serine/threonine kinase activity)|go:"GO:0090434"(oleoyl-CoA ligase activity)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|interpro:IPR000873(AMP-dependent synthetase and ligase)|interpro:IPR020845|reactome:R-RNO-2046105|reactome:R-RNO-2046106|reactome:R-RNO-75876	-	-	-	caution:"The participant EBI-349571(P68370) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919386(Q7TP47) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920972(Q5XIP9) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-916419(P11980) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919578(Q8R491) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920554(Q5U3Z7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920647(Q5U2X8) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920585(Q7TP24) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-779677(P05426) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-915744(P02454) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|agonist:Insulin was shown to increase or decrease GLUT4 protein interactions in specific cases.|comment:"Insulin decreased GLUT4 interactions with the following proteins: Q9ER30 (Sarcosin), P09527 (Rab-7), O88960 (N-ethylmaleimide sensitive), P09456 (PKA I regulatory subunit), P27881 (Hexokinase type II), P07872 (Acyl-coenzyme A oxidase), Q6DGF1 (Isocitrate dehydrogenase), Q9EQX9 (Ubiquitin-conjugating), Q63446 (Polyubiquitin), P24268 (Cathepsin D), Q91XW0 (Heat shock protein 86), Q5FVH0 (unknown), P58405 (Striatin 3), Q62667 (Major vault protein), Q66H50 (unknown), Q09167 (splicing factor), Q9JHU5 (Arfaptin 1)."|comment:"Insulin increased GLUT4 interaction with the following proteins:Q9Z1P2 (R-actinin-1), P45592 (Cofilin), Q9QXQ0 (R-actinin-4), P26473 (ADP-ribosylation factor), P26437 (ADP-ribosylation factor),   Q7TNP1 (Basigin 2), Q6P6R2 (Dihydrolipoamide dehydrogenase),   P04797 (GAPDH), Q63081 (Protein disulfide isomerase), P29457 (47 kDa heat shock protein), Q9R1J8 (Leprecan), O88638 (Putative eps protein),   Q64375 (Synaptonemal complex)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:NDPK - Interactions involving proteins containing InterPro domain IPR001564, Nucleoside diphosphate kinase, core.	taxid:10116(rat-l6)|taxid:10116(Rattus norvegicus)	-	2006/02/15	2021/11/30	rogid:PbFY2lfrty8yw40Jq7ShR7xfuV410116	rogid:GL6cDpmfm0GALcS0fQy0tDiSUlo10116	intact-crc:44F3A2176D02515F|rigid:9RVm0UBcqQF4k06RGKO89Bg16Q8	false	myc tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P19357	uniprotkb:P17764	intact:EBI-915426|uniprotkb:P97900|ensembl:ENSRNOP00000023256	intact:EBI-916725|ensembl:ENSRNOP00000010573	psi-mi:glut4_rat(display_long)|uniprotkb:Glucose transporter type 4, insulin-responsive(gene name synonym)|uniprotkb:Slc2a4(gene name)|psi-mi:Slc2a4(display_short)|uniprotkb:Glut4(gene name synonym)	psi-mi:thil_rat(display_long)|uniprotkb:Acetoacetyl-CoA thiolase(gene name synonym)|uniprotkb:Acat1(gene name)|psi-mi:Acat1(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Foster et al. (2006)	pubmed:16396496|mint:MINT-5218203	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-921030	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2711|refseq:NP_036883.1|refseq:XP_006246658.1|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007611"(learning or memory)|go:"GO:0007614"(short-term memory)|go:"GO:0007616"(long-term memory)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010021"(amylopectin biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031550"(positive regulation of brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044381"(glucose import in response to insulin stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046323"(glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0098694"(regulation of synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0098793"(presynapse)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002441("Glucose transporter, type 4 (GLUT4)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-189200|ensembl:ENSRNOG00000017226(gene)|ensembl:ENSRNOT00000023256(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)	rgd:2016|refseq:NP_058771.2|ensembl:ENSRNOG00000007862(gene)|ensembl:ENSRNOT00000010573(transcript)|go:"GO:0001889"(liver development)|go:"GO:0003985"(acetyl-CoA C-acetyltransferase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0006085"(acetyl-CoA biosynthetic process)|go:"GO:0006550"(isoleucine catabolic process)|go:"GO:0006635"(fatty acid beta-oxidation)|go:"GO:0007420"(brain development)|go:"GO:0009725"(response to hormone)|go:"GO:0014070"(response to organic cyclic compound)|go:"GO:0015936"(coenzyme A metabolic process)|go:"GO:0015937"(coenzyme A biosynthetic process)|go:"GO:0016453"(C-acetyltransferase activity)|go:"GO:0019899"(enzyme binding)|go:"GO:0030955"(potassium ion binding)|go:"GO:0042594"(response to starvation)|go:"GO:0042802"(identical protein binding)|go:"GO:0046356"(acetyl-CoA catabolic process)|go:"GO:0046952"(ketone body catabolic process)|go:"GO:0060612"(adipose tissue development)|go:"GO:0072229"(metanephric proximal convoluted tubule development)|go:"GO:0120225"(coenzyme A binding)|go:"GO:1902860"(propionyl-CoA biosynthetic process)|interpro:IPR002155(Thiolase)|interpro:IPR016039(Thiolase-like)|interpro:IPR020610|interpro:IPR020613|interpro:IPR020615|interpro:IPR020616|interpro:IPR020617|mint:P17764|reactome:R-RNO-70895|reactome:R-RNO-77108|reactome:R-RNO-77111	-	-	-	caution:"The participant EBI-349571(P68370) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919386(Q7TP47) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920972(Q5XIP9) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-916419(P11980) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919578(Q8R491) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920554(Q5U3Z7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920647(Q5U2X8) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920585(Q7TP24) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-779677(P05426) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-915744(P02454) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|agonist:Insulin was shown to increase or decrease GLUT4 protein interactions in specific cases.|comment:"Insulin decreased GLUT4 interactions with the following proteins: Q9ER30 (Sarcosin), P09527 (Rab-7), O88960 (N-ethylmaleimide sensitive), P09456 (PKA I regulatory subunit), P27881 (Hexokinase type II), P07872 (Acyl-coenzyme A oxidase), Q6DGF1 (Isocitrate dehydrogenase), Q9EQX9 (Ubiquitin-conjugating), Q63446 (Polyubiquitin), P24268 (Cathepsin D), Q91XW0 (Heat shock protein 86), Q5FVH0 (unknown), P58405 (Striatin 3), Q62667 (Major vault protein), Q66H50 (unknown), Q09167 (splicing factor), Q9JHU5 (Arfaptin 1)."|comment:"Insulin increased GLUT4 interaction with the following proteins:Q9Z1P2 (R-actinin-1), P45592 (Cofilin), Q9QXQ0 (R-actinin-4), P26473 (ADP-ribosylation factor), P26437 (ADP-ribosylation factor),   Q7TNP1 (Basigin 2), Q6P6R2 (Dihydrolipoamide dehydrogenase),   P04797 (GAPDH), Q63081 (Protein disulfide isomerase), P29457 (47 kDa heat shock protein), Q9R1J8 (Leprecan), O88638 (Putative eps protein),   Q64375 (Synaptonemal complex)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:NDPK - Interactions involving proteins containing InterPro domain IPR001564, Nucleoside diphosphate kinase, core.	taxid:10116(rat-l6)|taxid:10116(Rattus norvegicus)	-	2006/02/15	2021/11/30	rogid:PbFY2lfrty8yw40Jq7ShR7xfuV410116	rogid:vDtJ++0tEuC/RrdJDpDUzON/n4g10116	intact-crc:44F3A2176D02515F|rigid:9RVm0UBcqQF4k06RGKO89Bg16Q8	false	myc tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P19357	uniprotkb:P17220	intact:EBI-915426|uniprotkb:P97900|ensembl:ENSRNOP00000023256	intact:EBI-916719|ensembl:ENSRNOP00000066950	psi-mi:glut4_rat(display_long)|uniprotkb:Glucose transporter type 4, insulin-responsive(gene name synonym)|uniprotkb:Slc2a4(gene name)|psi-mi:Slc2a4(display_short)|uniprotkb:Glut4(gene name synonym)	psi-mi:psa2_rat(display_long)|uniprotkb:Proteasome component C3(gene name synonym)|uniprotkb:Macropain subunit C3(gene name synonym)|uniprotkb:Multicatalytic endopeptidase complex subunit C3(gene name synonym)|uniprotkb:Psma2(gene name)|psi-mi:Psma2(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Foster et al. (2006)	pubmed:16396496|mint:MINT-5218203	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-921030	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2711|refseq:NP_036883.1|refseq:XP_006246658.1|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007611"(learning or memory)|go:"GO:0007614"(short-term memory)|go:"GO:0007616"(long-term memory)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010021"(amylopectin biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031550"(positive regulation of brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044381"(glucose import in response to insulin stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046323"(glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0098694"(regulation of synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0098793"(presynapse)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002441("Glucose transporter, type 4 (GLUT4)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-189200|ensembl:ENSRNOG00000017226(gene)|ensembl:ENSRNOT00000023256(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)	rgd:61842|refseq:NP_058975.1|interpro:IPR023332|interpro:IPR029055|interpro:IPR034644|rcsb pdb:6EPC|rcsb pdb:6EPD|rcsb pdb:6EPE|rcsb pdb:6EPF|rcsb pdb:6TU3|reactome:R-RNO-1169091|reactome:R-RNO-1234176|reactome:R-RNO-1236978|reactome:R-RNO-174084|reactome:R-RNO-174154|reactome:R-RNO-174178|reactome:R-RNO-174184|reactome:R-RNO-187577|reactome:R-RNO-195253|reactome:R-RNO-2467813|reactome:R-RNO-349425|reactome:R-RNO-350562|reactome:R-RNO-382556|reactome:R-RNO-450408|reactome:R-RNO-4608870|reactome:R-RNO-4641257|ensembl:ENSRNOT00000073834(transcript)|go:"GO:0000502"(proteasome complex)|go:"GO:0000932"(P-body)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005839"(proteasome core complex)|go:"GO:0009615"(response to virus)|go:"GO:0010499"(proteasomal ubiquitin-independent protein catabolic process)|go:"GO:0019773"(proteasome core complex, alpha-subunit complex)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|interpro:IPR000426(Proteasome alpha-subunit, conserved site)|interpro:IPR001353(20S proteasome, A and B subunits)|ensembl:ENSRNOG00000049920(gene)|reactome:R-RNO-4641258|reactome:R-RNO-5358346|reactome:R-RNO-5607761|reactome:R-RNO-5610780|reactome:R-RNO-5610785|reactome:R-RNO-5632684|reactome:R-RNO-5658442|reactome:R-RNO-5668541|reactome:R-RNO-5676590|reactome:R-RNO-5687128|reactome:R-RNO-5689603|reactome:R-RNO-5689880|reactome:R-RNO-6798695|reactome:R-RNO-68827|reactome:R-RNO-68949|reactome:R-RNO-69017|reactome:R-RNO-69481|reactome:R-RNO-69601|reactome:R-RNO-75815|reactome:R-RNO-8852276|reactome:R-RNO-8854050|reactome:R-RNO-8932339|reactome:R-RNO-8939236|reactome:R-RNO-8941858|reactome:R-RNO-8948751|reactome:R-RNO-8951664|reactome:R-RNO-983168	-	-	-	caution:"The participant EBI-349571(P68370) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919386(Q7TP47) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920972(Q5XIP9) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-916419(P11980) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919578(Q8R491) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920554(Q5U3Z7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920647(Q5U2X8) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920585(Q7TP24) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-779677(P05426) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-915744(P02454) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|agonist:Insulin was shown to increase or decrease GLUT4 protein interactions in specific cases.|comment:"Insulin decreased GLUT4 interactions with the following proteins: Q9ER30 (Sarcosin), P09527 (Rab-7), O88960 (N-ethylmaleimide sensitive), P09456 (PKA I regulatory subunit), P27881 (Hexokinase type II), P07872 (Acyl-coenzyme A oxidase), Q6DGF1 (Isocitrate dehydrogenase), Q9EQX9 (Ubiquitin-conjugating), Q63446 (Polyubiquitin), P24268 (Cathepsin D), Q91XW0 (Heat shock protein 86), Q5FVH0 (unknown), P58405 (Striatin 3), Q62667 (Major vault protein), Q66H50 (unknown), Q09167 (splicing factor), Q9JHU5 (Arfaptin 1)."|comment:"Insulin increased GLUT4 interaction with the following proteins:Q9Z1P2 (R-actinin-1), P45592 (Cofilin), Q9QXQ0 (R-actinin-4), P26473 (ADP-ribosylation factor), P26437 (ADP-ribosylation factor),   Q7TNP1 (Basigin 2), Q6P6R2 (Dihydrolipoamide dehydrogenase),   P04797 (GAPDH), Q63081 (Protein disulfide isomerase), P29457 (47 kDa heat shock protein), Q9R1J8 (Leprecan), O88638 (Putative eps protein),   Q64375 (Synaptonemal complex)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:NDPK - Interactions involving proteins containing InterPro domain IPR001564, Nucleoside diphosphate kinase, core.	taxid:10116(rat-l6)|taxid:10116(Rattus norvegicus)	-	2006/02/15	2021/11/30	rogid:PbFY2lfrty8yw40Jq7ShR7xfuV410116	rogid:nKRiQheHfS3+3anLub61WsVVtFE10116	intact-crc:44F3A2176D02515F|rigid:9RVm0UBcqQF4k06RGKO89Bg16Q8	false	myc tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P19357	uniprotkb:P17209	intact:EBI-915426|uniprotkb:P97900|ensembl:ENSRNOP00000023256	intact:EBI-916713	psi-mi:glut4_rat(display_long)|uniprotkb:Glucose transporter type 4, insulin-responsive(gene name synonym)|uniprotkb:Slc2a4(gene name)|psi-mi:Slc2a4(display_short)|uniprotkb:Glut4(gene name synonym)	psi-mi:myl4_rat(display_long)|uniprotkb:Myosin light chain 1, atrial isoform(gene name synonym)|uniprotkb:Myl4(gene name)|psi-mi:Myl4(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Foster et al. (2006)	pubmed:16396496|mint:MINT-5218203	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-921030	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2711|refseq:NP_036883.1|refseq:XP_006246658.1|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007611"(learning or memory)|go:"GO:0007614"(short-term memory)|go:"GO:0007616"(long-term memory)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010021"(amylopectin biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031550"(positive regulation of brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044381"(glucose import in response to insulin stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046323"(glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0098694"(regulation of synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0098793"(presynapse)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002441("Glucose transporter, type 4 (GLUT4)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-189200|ensembl:ENSRNOG00000017226(gene)|ensembl:ENSRNOT00000023256(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)	interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR011992(EF-Hand type)|rgd:1591197|reactome:R-RNO-390522|go:"GO:0002026"(regulation of the force of heart contraction)|go:"GO:0003785"(actin monomer binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0016459"(myosin complex)|go:"GO:0031672"(A band)|go:"GO:0032781"(positive regulation of ATP-dependent activity)|go:"GO:0051015"(actin filament binding)|go:"GO:0060048"(cardiac muscle contraction)	-	-	-	caution:"The participant EBI-349571(P68370) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919386(Q7TP47) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920972(Q5XIP9) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-916419(P11980) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919578(Q8R491) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920554(Q5U3Z7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920647(Q5U2X8) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920585(Q7TP24) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-779677(P05426) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-915744(P02454) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|agonist:Insulin was shown to increase or decrease GLUT4 protein interactions in specific cases.|comment:"Insulin decreased GLUT4 interactions with the following proteins: Q9ER30 (Sarcosin), P09527 (Rab-7), O88960 (N-ethylmaleimide sensitive), P09456 (PKA I regulatory subunit), P27881 (Hexokinase type II), P07872 (Acyl-coenzyme A oxidase), Q6DGF1 (Isocitrate dehydrogenase), Q9EQX9 (Ubiquitin-conjugating), Q63446 (Polyubiquitin), P24268 (Cathepsin D), Q91XW0 (Heat shock protein 86), Q5FVH0 (unknown), P58405 (Striatin 3), Q62667 (Major vault protein), Q66H50 (unknown), Q09167 (splicing factor), Q9JHU5 (Arfaptin 1)."|comment:"Insulin increased GLUT4 interaction with the following proteins:Q9Z1P2 (R-actinin-1), P45592 (Cofilin), Q9QXQ0 (R-actinin-4), P26473 (ADP-ribosylation factor), P26437 (ADP-ribosylation factor),   Q7TNP1 (Basigin 2), Q6P6R2 (Dihydrolipoamide dehydrogenase),   P04797 (GAPDH), Q63081 (Protein disulfide isomerase), P29457 (47 kDa heat shock protein), Q9R1J8 (Leprecan), O88638 (Putative eps protein),   Q64375 (Synaptonemal complex)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:NDPK - Interactions involving proteins containing InterPro domain IPR001564, Nucleoside diphosphate kinase, core.	taxid:10116(rat-l6)|taxid:10116(Rattus norvegicus)	-	2006/02/15	2021/11/30	rogid:PbFY2lfrty8yw40Jq7ShR7xfuV410116	rogid:nNuKeB77ZYD9pbUK7hSOW0XbaTU10116	intact-crc:44F3A2176D02515F|rigid:9RVm0UBcqQF4k06RGKO89Bg16Q8	false	myc tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P19357	uniprotkb:P17164	intact:EBI-915426|uniprotkb:P97900|ensembl:ENSRNOP00000023256	intact:EBI-916703|uniprotkb:Q642C6	psi-mi:glut4_rat(display_long)|uniprotkb:Glucose transporter type 4, insulin-responsive(gene name synonym)|uniprotkb:Slc2a4(gene name)|psi-mi:Slc2a4(display_short)|uniprotkb:Glut4(gene name synonym)	psi-mi:fuco_rat(display_long)|uniprotkb:Alpha-L-fucoside fucohydrolase 1(gene name synonym)|uniprotkb:Alpha-L-fucosidase I(gene name synonym)|uniprotkb:Fuca1(gene name)|psi-mi:Fuca1(display_short)|uniprotkb:Fuca(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Foster et al. (2006)	pubmed:16396496|mint:MINT-5218203	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-921030	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2711|refseq:NP_036883.1|refseq:XP_006246658.1|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007611"(learning or memory)|go:"GO:0007614"(short-term memory)|go:"GO:0007616"(long-term memory)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010021"(amylopectin biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031550"(positive regulation of brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044381"(glucose import in response to insulin stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046323"(glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0098694"(regulation of synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0098793"(presynapse)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002441("Glucose transporter, type 4 (GLUT4)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-189200|ensembl:ENSRNOG00000017226(gene)|ensembl:ENSRNOT00000023256(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)	rgd:2636|refseq:NP_036694.2|interpro:IPR000933("Glycoside hydrolase, family 29 (alpha-L-fucosidase)")|interpro:IPR018526|interpro:IPR016286(Alpha-L-fucosidase)|interpro:IPR017853(Glycoside hydrolase, catalytic core)|reactome:R-RNO-6798695|reactome:R-RNO-975578|go:"GO:0004560"(alpha-L-fucosidase activity)|go:"GO:0005764"(lysosome)|go:"GO:0006004"(fucose metabolic process)|go:"GO:0015928"(fucosidase activity)|go:"GO:0016139"(glycoside catabolic process)|go:"GO:0030246"(carbohydrate binding)|interpro:IPR031919|interpro:IPR028755|interpro:IPR013780(Glycosyl hydrolase, family 13, all-beta)	-	-	-	caution:"The participant EBI-349571(P68370) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919386(Q7TP47) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920972(Q5XIP9) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-916419(P11980) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919578(Q8R491) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920554(Q5U3Z7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920647(Q5U2X8) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920585(Q7TP24) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-779677(P05426) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-915744(P02454) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|agonist:Insulin was shown to increase or decrease GLUT4 protein interactions in specific cases.|comment:"Insulin decreased GLUT4 interactions with the following proteins: Q9ER30 (Sarcosin), P09527 (Rab-7), O88960 (N-ethylmaleimide sensitive), P09456 (PKA I regulatory subunit), P27881 (Hexokinase type II), P07872 (Acyl-coenzyme A oxidase), Q6DGF1 (Isocitrate dehydrogenase), Q9EQX9 (Ubiquitin-conjugating), Q63446 (Polyubiquitin), P24268 (Cathepsin D), Q91XW0 (Heat shock protein 86), Q5FVH0 (unknown), P58405 (Striatin 3), Q62667 (Major vault protein), Q66H50 (unknown), Q09167 (splicing factor), Q9JHU5 (Arfaptin 1)."|comment:"Insulin increased GLUT4 interaction with the following proteins:Q9Z1P2 (R-actinin-1), P45592 (Cofilin), Q9QXQ0 (R-actinin-4), P26473 (ADP-ribosylation factor), P26437 (ADP-ribosylation factor),   Q7TNP1 (Basigin 2), Q6P6R2 (Dihydrolipoamide dehydrogenase),   P04797 (GAPDH), Q63081 (Protein disulfide isomerase), P29457 (47 kDa heat shock protein), Q9R1J8 (Leprecan), O88638 (Putative eps protein),   Q64375 (Synaptonemal complex)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:NDPK - Interactions involving proteins containing InterPro domain IPR001564, Nucleoside diphosphate kinase, core.	taxid:10116(rat-l6)|taxid:10116(Rattus norvegicus)	-	2006/02/15	2021/11/30	rogid:PbFY2lfrty8yw40Jq7ShR7xfuV410116	rogid:JOOIqyEf4Nf9XXJ6siX0Eq61PzE10116	intact-crc:44F3A2176D02515F|rigid:9RVm0UBcqQF4k06RGKO89Bg16Q8	false	myc tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P19357	uniprotkb:P62828	intact:EBI-915426|uniprotkb:P97900|ensembl:ENSRNOP00000023256	intact:EBI-286590|uniprotkb:P17080|uniprotkb:P28746|uniprotkb:P28747|uniprotkb:Q9CSP3|uniprotkb:Q9CWI7|uniprotkb:Q9CZA2|uniprotkb:Q9UEU9|uniprotkb:Q9UDJ5|ensembl:ENSRNOP00000001247	psi-mi:glut4_rat(display_long)|uniprotkb:Glucose transporter type 4, insulin-responsive(gene name synonym)|uniprotkb:Slc2a4(gene name)|psi-mi:Slc2a4(display_short)|uniprotkb:Glut4(gene name synonym)	psi-mi:ran_rat(display_long)|uniprotkb:GTPase Ran(gene name synonym)|uniprotkb:Ras-related nuclear protein(gene name synonym)|uniprotkb:Ras-like protein TC4(gene name synonym)|uniprotkb:Ran(gene name)|psi-mi:Ran(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Foster et al. (2006)	pubmed:16396496|mint:MINT-5218203	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-921030	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2711|refseq:NP_036883.1|refseq:XP_006246658.1|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007611"(learning or memory)|go:"GO:0007614"(short-term memory)|go:"GO:0007616"(long-term memory)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010021"(amylopectin biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031550"(positive regulation of brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044381"(glucose import in response to insulin stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046323"(glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0098694"(regulation of synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0098793"(presynapse)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002441("Glucose transporter, type 4 (GLUT4)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-189200|ensembl:ENSRNOG00000017226(gene)|ensembl:ENSRNOT00000023256(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)	rgd:620367|refseq:NP_445891.1|refseq:XP_006249347.1|ensembl:ENSRNOG00000000938(gene)|ensembl:ENSRNOT00000001247(transcript)|go:"GO:0000054"(ribosomal subunit export from nucleus)|go:"GO:0000055"(ribosomal large subunit export from nucleus)|go:"GO:0000056"(ribosomal small subunit export from nucleus)|go:"GO:0000070"(mitotic sister chromatid segregation)|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0001673"(male germ cell nucleus)|go:"GO:0002177"(manchette)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005643"(nuclear pore)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005814"(centriole)|go:"GO:0005829"(cytosol)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0006611"(protein export from nucleus)|go:"GO:0006913"(nucleocytoplasmic transport)|go:"GO:0007286"(spermatid development)|go:"GO:0014070"(response to organic cyclic compound)|go:"GO:0019003"(GDP binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0021766"(hippocampus development)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030496"(midbody)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034613"(cellular protein localization)|go:"GO:0034629"|go:"GO:0036126"(sperm flagellum)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0042470"(melanosome)|go:"GO:0042565"(RNA nuclear export complex)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045505"(dynein intermediate chain binding)|go:"GO:0046039"(GTP metabolic process)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051301"(cell division)|go:"GO:0055037"(recycling endosome)|go:"GO:0061015"(snRNA import into nucleus)|go:"GO:0061676"(importin-alpha family protein binding)|go:"GO:0071389"(cellular response to mineralocorticoid stimulus)|go:"GO:1902570"(protein localization to nucleolus)|interpro:IPR001806(Ras GTPase)|interpro:IPR002041(Ran GTPase)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR027417|reactome:R-RNO-1655829|reactome:R-RNO-5578749|reactome:R-RNO-9615933	-	-	-	caution:"The participant EBI-349571(P68370) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919386(Q7TP47) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920972(Q5XIP9) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-916419(P11980) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919578(Q8R491) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920554(Q5U3Z7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920647(Q5U2X8) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920585(Q7TP24) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-779677(P05426) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-915744(P02454) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|agonist:Insulin was shown to increase or decrease GLUT4 protein interactions in specific cases.|comment:"Insulin decreased GLUT4 interactions with the following proteins: Q9ER30 (Sarcosin), P09527 (Rab-7), O88960 (N-ethylmaleimide sensitive), P09456 (PKA I regulatory subunit), P27881 (Hexokinase type II), P07872 (Acyl-coenzyme A oxidase), Q6DGF1 (Isocitrate dehydrogenase), Q9EQX9 (Ubiquitin-conjugating), Q63446 (Polyubiquitin), P24268 (Cathepsin D), Q91XW0 (Heat shock protein 86), Q5FVH0 (unknown), P58405 (Striatin 3), Q62667 (Major vault protein), Q66H50 (unknown), Q09167 (splicing factor), Q9JHU5 (Arfaptin 1)."|comment:"Insulin increased GLUT4 interaction with the following proteins:Q9Z1P2 (R-actinin-1), P45592 (Cofilin), Q9QXQ0 (R-actinin-4), P26473 (ADP-ribosylation factor), P26437 (ADP-ribosylation factor),   Q7TNP1 (Basigin 2), Q6P6R2 (Dihydrolipoamide dehydrogenase),   P04797 (GAPDH), Q63081 (Protein disulfide isomerase), P29457 (47 kDa heat shock protein), Q9R1J8 (Leprecan), O88638 (Putative eps protein),   Q64375 (Synaptonemal complex)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:NDPK - Interactions involving proteins containing InterPro domain IPR001564, Nucleoside diphosphate kinase, core.	taxid:10116(rat-l6)|taxid:10116(Rattus norvegicus)	-	2006/02/15	2021/11/30	rogid:PbFY2lfrty8yw40Jq7ShR7xfuV410116	rogid:trIUv5n3nI5d0rkfDTgw/6ubxMA10116	intact-crc:44F3A2176D02515F|rigid:9RVm0UBcqQF4k06RGKO89Bg16Q8	false	myc tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P19357	uniprotkb:P17077	intact:EBI-915426|uniprotkb:P97900|ensembl:ENSRNOP00000023256	intact:EBI-916697|ensembl:ENSRNOP00000032635|ensembl:ENSRNOP00000041817|ensembl:ENSRNOP00000068363|ensembl:ENSRNOP00000069650	psi-mi:glut4_rat(display_long)|uniprotkb:Glucose transporter type 4, insulin-responsive(gene name synonym)|uniprotkb:Slc2a4(gene name)|psi-mi:Slc2a4(display_short)|uniprotkb:Glut4(gene name synonym)	psi-mi:rl9_rat(display_long)|uniprotkb:Rpl9(gene name)|psi-mi:Rpl9(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Foster et al. (2006)	pubmed:16396496|mint:MINT-5218203	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-921030	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2711|refseq:NP_036883.1|refseq:XP_006246658.1|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007611"(learning or memory)|go:"GO:0007614"(short-term memory)|go:"GO:0007616"(long-term memory)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010021"(amylopectin biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031550"(positive regulation of brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044381"(glucose import in response to insulin stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046323"(glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0098694"(regulation of synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0098793"(presynapse)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002441("Glucose transporter, type 4 (GLUT4)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-189200|ensembl:ENSRNOG00000017226(gene)|ensembl:ENSRNOT00000023256(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)	rgd:62049|refseq:NP_001007599.3|refseq:XP_002725578.1|refseq:XP_002729193.1|refseq:XP_003748822.1|refseq:XP_003753735.1|ensembl:ENSRNOG00000026716(gene)|ensembl:ENSRNOG00000028449(gene)|ensembl:ENSRNOG00000030476(gene)|ensembl:ENSRNOT00000038927(transcript)|ensembl:ENSRNOT00000042201(transcript)|ensembl:ENSRNOT00000052231(transcript)|ensembl:ENSRNOT00000076245(transcript)|go:"GO:0002181"(cytoplasmic translation)|go:"GO:0003735"(structural constituent of ribosome)|go:"GO:0019843"(rRNA binding)|go:"GO:0022625"(cytosolic large ribosomal subunit)|go:"GO:0022626"(cytosolic ribosome)|go:"GO:0045202"(synapse)|go:"GO:1990090"(cellular response to nerve growth factor stimulus)|interpro:IPR000702(Ribosomal protein L6)|interpro:IPR002359(Ribosomal protein L6, conserved site-2)|interpro:IPR020040|interpro:IPR036789|reactome:R-RNO-156827|reactome:R-RNO-1799339|reactome:R-RNO-6791226|reactome:R-RNO-72689|reactome:R-RNO-72706|reactome:R-RNO-975956|reactome:R-RNO-975957	-	-	-	caution:"The participant EBI-349571(P68370) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919386(Q7TP47) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920972(Q5XIP9) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-916419(P11980) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919578(Q8R491) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920554(Q5U3Z7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920647(Q5U2X8) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920585(Q7TP24) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-779677(P05426) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-915744(P02454) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|agonist:Insulin was shown to increase or decrease GLUT4 protein interactions in specific cases.|comment:"Insulin decreased GLUT4 interactions with the following proteins: Q9ER30 (Sarcosin), P09527 (Rab-7), O88960 (N-ethylmaleimide sensitive), P09456 (PKA I regulatory subunit), P27881 (Hexokinase type II), P07872 (Acyl-coenzyme A oxidase), Q6DGF1 (Isocitrate dehydrogenase), Q9EQX9 (Ubiquitin-conjugating), Q63446 (Polyubiquitin), P24268 (Cathepsin D), Q91XW0 (Heat shock protein 86), Q5FVH0 (unknown), P58405 (Striatin 3), Q62667 (Major vault protein), Q66H50 (unknown), Q09167 (splicing factor), Q9JHU5 (Arfaptin 1)."|comment:"Insulin increased GLUT4 interaction with the following proteins:Q9Z1P2 (R-actinin-1), P45592 (Cofilin), Q9QXQ0 (R-actinin-4), P26473 (ADP-ribosylation factor), P26437 (ADP-ribosylation factor),   Q7TNP1 (Basigin 2), Q6P6R2 (Dihydrolipoamide dehydrogenase),   P04797 (GAPDH), Q63081 (Protein disulfide isomerase), P29457 (47 kDa heat shock protein), Q9R1J8 (Leprecan), O88638 (Putative eps protein),   Q64375 (Synaptonemal complex)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:NDPK - Interactions involving proteins containing InterPro domain IPR001564, Nucleoside diphosphate kinase, core.	taxid:10116(rat-l6)|taxid:10116(Rattus norvegicus)	-	2006/02/15	2021/11/30	rogid:PbFY2lfrty8yw40Jq7ShR7xfuV410116	rogid:mKmuME+fis8sQm9ws1m8e0tRkio10116	intact-crc:44F3A2176D02515F|rigid:9RVm0UBcqQF4k06RGKO89Bg16Q8	false	myc tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P19357	uniprotkb:P17074	intact:EBI-915426|uniprotkb:P97900|ensembl:ENSRNOP00000023256	intact:EBI-916692|ensembl:ENSRNOP00000027246	psi-mi:glut4_rat(display_long)|uniprotkb:Glucose transporter type 4, insulin-responsive(gene name synonym)|uniprotkb:Slc2a4(gene name)|psi-mi:Slc2a4(display_short)|uniprotkb:Glut4(gene name synonym)	psi-mi:rs19_rat(display_long)|uniprotkb:Rps19(gene name)|psi-mi:Rps19(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Foster et al. (2006)	pubmed:16396496|mint:MINT-5218203	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-921030	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2711|refseq:NP_036883.1|refseq:XP_006246658.1|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007611"(learning or memory)|go:"GO:0007614"(short-term memory)|go:"GO:0007616"(long-term memory)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010021"(amylopectin biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031550"(positive regulation of brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044381"(glucose import in response to insulin stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046323"(glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0098694"(regulation of synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0098793"(presynapse)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002441("Glucose transporter, type 4 (GLUT4)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-189200|ensembl:ENSRNOG00000017226(gene)|ensembl:ENSRNOT00000023256(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)	rgd:68440|refseq:NP_001032423.1|refseq:XP_006228473.1|refseq:XP_017444775.1|refseq:XP_017444777.1|refseq:XP_017445502.1|ensembl:ENSRNOG00000037897(gene)|ensembl:ENSRNOT00000027246(transcript)|go:"GO:0000028"(ribosomal small subunit assembly)|go:"GO:0003723"(RNA binding)|go:"GO:0003735"(structural constituent of ribosome)|go:"GO:0005730"(nucleolus)|go:"GO:0006412"(translation)|go:"GO:0007219"(Notch signaling pathway)|go:"GO:0022627"(cytosolic small ribosomal subunit)|go:"GO:0030218"(erythrocyte differentiation)|go:"GO:0031369"(translation initiation factor binding)|go:"GO:0045202"(synapse)|interpro:IPR001266(Ribosomal protein S19e)|interpro:IPR018277|interpro:IPR036388|interpro:IPR036390|mint:P17074|reactome:R-RNO-156827|reactome:R-RNO-1799339|reactome:R-RNO-6791226|reactome:R-RNO-72649|reactome:R-RNO-72689|reactome:R-RNO-72695|reactome:R-RNO-72702|reactome:R-RNO-72706|reactome:R-RNO-975956|reactome:R-RNO-975957	-	-	-	caution:"The participant EBI-349571(P68370) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919386(Q7TP47) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920972(Q5XIP9) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-916419(P11980) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919578(Q8R491) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920554(Q5U3Z7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920647(Q5U2X8) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920585(Q7TP24) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-779677(P05426) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-915744(P02454) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|agonist:Insulin was shown to increase or decrease GLUT4 protein interactions in specific cases.|comment:"Insulin decreased GLUT4 interactions with the following proteins: Q9ER30 (Sarcosin), P09527 (Rab-7), O88960 (N-ethylmaleimide sensitive), P09456 (PKA I regulatory subunit), P27881 (Hexokinase type II), P07872 (Acyl-coenzyme A oxidase), Q6DGF1 (Isocitrate dehydrogenase), Q9EQX9 (Ubiquitin-conjugating), Q63446 (Polyubiquitin), P24268 (Cathepsin D), Q91XW0 (Heat shock protein 86), Q5FVH0 (unknown), P58405 (Striatin 3), Q62667 (Major vault protein), Q66H50 (unknown), Q09167 (splicing factor), Q9JHU5 (Arfaptin 1)."|comment:"Insulin increased GLUT4 interaction with the following proteins:Q9Z1P2 (R-actinin-1), P45592 (Cofilin), Q9QXQ0 (R-actinin-4), P26473 (ADP-ribosylation factor), P26437 (ADP-ribosylation factor),   Q7TNP1 (Basigin 2), Q6P6R2 (Dihydrolipoamide dehydrogenase),   P04797 (GAPDH), Q63081 (Protein disulfide isomerase), P29457 (47 kDa heat shock protein), Q9R1J8 (Leprecan), O88638 (Putative eps protein),   Q64375 (Synaptonemal complex)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:NDPK - Interactions involving proteins containing InterPro domain IPR001564, Nucleoside diphosphate kinase, core.	taxid:10116(rat-l6)|taxid:10116(Rattus norvegicus)	-	2006/02/15	2021/11/30	rogid:PbFY2lfrty8yw40Jq7ShR7xfuV410116	rogid:D3A6ULv7RIjBdw3qPwrdoWZ+F4U10116	intact-crc:44F3A2176D02515F|rigid:9RVm0UBcqQF4k06RGKO89Bg16Q8	false	myc tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P19357	uniprotkb:P61354	intact:EBI-915426|uniprotkb:P97900|ensembl:ENSRNOP00000023256	intact:EBI-352771|ensembl:ENSRNOP00000028060|uniprotkb:P08526|uniprotkb:Q5BJ97	psi-mi:glut4_rat(display_long)|uniprotkb:Glucose transporter type 4, insulin-responsive(gene name synonym)|uniprotkb:Slc2a4(gene name)|psi-mi:Slc2a4(display_short)|uniprotkb:Glut4(gene name synonym)	psi-mi:rl27_rat(display_long)|uniprotkb:Rpl27(gene name)|psi-mi:Rpl27(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Foster et al. (2006)	pubmed:16396496|mint:MINT-5218203	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-921030	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2711|refseq:NP_036883.1|refseq:XP_006246658.1|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007611"(learning or memory)|go:"GO:0007614"(short-term memory)|go:"GO:0007616"(long-term memory)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010021"(amylopectin biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031550"(positive regulation of brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044381"(glucose import in response to insulin stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046323"(glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0098694"(regulation of synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0098793"(presynapse)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002441("Glucose transporter, type 4 (GLUT4)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-189200|ensembl:ENSRNOG00000017226(gene)|ensembl:ENSRNOT00000023256(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)	reactome:R-RNO-72706|reactome:R-RNO-975956|reactome:R-RNO-975957|reactome:R-RNO-72689|ensembl:ENSRNOG00000020674(gene)|ensembl:ENSRNOT00000028060(transcript)|go:"GO:0003735"(structural constituent of ribosome)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005840"(ribosome)|go:"GO:0006364"(rRNA processing)|go:"GO:0006412"(translation)|go:"GO:0022625"(cytosolic large ribosomal subunit)|go:"GO:0022626"(cytosolic ribosome)|go:"GO:0098556"(cytoplasmic side of rough endoplasmic reticulum membrane)|go:"GO:1904044"(response to aldosterone)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR001141(Ribosomal protein L27e)|interpro:IPR005824(KOW)|interpro:IPR008991(Translation protein SH3-like)|interpro:IPR018262|interpro:IPR038655|interpro:IPR041991|mint:P61354|reactome:R-RNO-156827|reactome:R-RNO-1799339|reactome:R-RNO-6791226|rgd:621192|refseq:NP_071959.1	-	-	-	caution:"The participant EBI-349571(P68370) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919386(Q7TP47) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920972(Q5XIP9) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-916419(P11980) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919578(Q8R491) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920554(Q5U3Z7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920647(Q5U2X8) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920585(Q7TP24) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-779677(P05426) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-915744(P02454) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|agonist:Insulin was shown to increase or decrease GLUT4 protein interactions in specific cases.|comment:"Insulin decreased GLUT4 interactions with the following proteins: Q9ER30 (Sarcosin), P09527 (Rab-7), O88960 (N-ethylmaleimide sensitive), P09456 (PKA I regulatory subunit), P27881 (Hexokinase type II), P07872 (Acyl-coenzyme A oxidase), Q6DGF1 (Isocitrate dehydrogenase), Q9EQX9 (Ubiquitin-conjugating), Q63446 (Polyubiquitin), P24268 (Cathepsin D), Q91XW0 (Heat shock protein 86), Q5FVH0 (unknown), P58405 (Striatin 3), Q62667 (Major vault protein), Q66H50 (unknown), Q09167 (splicing factor), Q9JHU5 (Arfaptin 1)."|comment:"Insulin increased GLUT4 interaction with the following proteins:Q9Z1P2 (R-actinin-1), P45592 (Cofilin), Q9QXQ0 (R-actinin-4), P26473 (ADP-ribosylation factor), P26437 (ADP-ribosylation factor),   Q7TNP1 (Basigin 2), Q6P6R2 (Dihydrolipoamide dehydrogenase),   P04797 (GAPDH), Q63081 (Protein disulfide isomerase), P29457 (47 kDa heat shock protein), Q9R1J8 (Leprecan), O88638 (Putative eps protein),   Q64375 (Synaptonemal complex)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:NDPK - Interactions involving proteins containing InterPro domain IPR001564, Nucleoside diphosphate kinase, core.	taxid:10116(rat-l6)|taxid:10116(Rattus norvegicus)	-	2006/02/15	2021/11/30	rogid:PbFY2lfrty8yw40Jq7ShR7xfuV410116	rogid:TLWbAcdRKUb2ijDYjSUa1sbixis10116	intact-crc:44F3A2176D02515F|rigid:9RVm0UBcqQF4k06RGKO89Bg16Q8	false	myc tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P19357	uniprotkb:P62909	intact:EBI-915426|uniprotkb:P97900|ensembl:ENSRNOP00000023256	intact:EBI-432553|uniprotkb:P17073|uniprotkb:P47933|ensembl:ENSRNOP00000023935	psi-mi:glut4_rat(display_long)|uniprotkb:Glucose transporter type 4, insulin-responsive(gene name synonym)|uniprotkb:Slc2a4(gene name)|psi-mi:Slc2a4(display_short)|uniprotkb:Glut4(gene name synonym)	psi-mi:rs3_rat(display_long)|uniprotkb:Rps3(gene name)|psi-mi:Rps3(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Foster et al. (2006)	pubmed:16396496|mint:MINT-5218203	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-921030	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2711|refseq:NP_036883.1|refseq:XP_006246658.1|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007611"(learning or memory)|go:"GO:0007614"(short-term memory)|go:"GO:0007616"(long-term memory)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010021"(amylopectin biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031550"(positive regulation of brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044381"(glucose import in response to insulin stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046323"(glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0098694"(regulation of synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0098793"(presynapse)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002441("Glucose transporter, type 4 (GLUT4)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-189200|ensembl:ENSRNOG00000017226(gene)|ensembl:ENSRNOT00000023256(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)	rgd:619888|refseq:NP_001009239.1|ensembl:ENSRNOG00000017418(gene)|ensembl:ENSRNOT00000023935(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003684"(damaged DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0003906"("DNA-(apurinic or apyrimidinic site) endonuclease activity")|go:"GO:0004520"(endodeoxyribonuclease activity)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005829"(cytosol)|go:"GO:0005840"(ribosome)|go:"GO:0005844"(polysome)|go:"GO:0005886"(plasma membrane)|go:"GO:0006281"(DNA repair)|go:"GO:0006412"(translation)|go:"GO:0003735"(structural constituent of ribosome)|go:"GO:0006915"(apoptotic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007059"(chromosome segregation)|go:"GO:0008017"(microtubule binding)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0012505"(endomembrane system)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015631"(tubulin binding)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0019899"(enzyme binding)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0022626"(cytosolic ribosome)|go:"GO:0022627"(cytosolic small ribosomal subunit)|go:"GO:0030425"(dendrite)|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0031116"(positive regulation of microtubule polymerization)|go:"GO:0031334"(positive regulation of protein-containing complex assembly)|go:"GO:0031397"(negative regulation of protein ubiquitination)|go:"GO:0032079"(positive regulation of endodeoxyribonuclease activity)|go:"GO:0032357"(oxidized purine DNA binding)|go:"GO:0032358"(oxidized pyrimidine DNA binding)|go:"GO:0032587"(ruffle membrane)|go:"GO:0032743"(positive regulation of interleukin-2 production)|go:"GO:0034614"(cellular response to reactive oxygen species)|go:"GO:0042104"(positive regulation of activated T cell proliferation)|go:"GO:0042769"(obsolete DNA damage response, detection of DNA damage)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0044390"(ubiquitin-like protein conjugating enzyme binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045738"(negative regulation of DNA repair)|go:"GO:0045739"(positive regulation of DNA repair)|go:"GO:0050862"(positive regulation of T cell receptor signaling pathway)|go:"GO:0051018"(protein kinase A binding)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051225"(spindle assembly)|go:"GO:0051301"(cell division)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0061481"(response to TNF agonist)|go:"GO:0070181"(small ribosomal subunit rRNA binding)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0071159"(NF-kappaB complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0072686"(mitotic spindle)|go:"GO:0097100"(supercoiled DNA binding)|go:"GO:0140078"("class I DNA-(apurinic or apyrimidinic site) endonuclease activity")|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:1902231"(positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:1902546"(positive regulation of DNA N-glycosylase activity)|go:"GO:2001235"(positive regulation of apoptotic signaling pathway)|go:"GO:2001272"(positive regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis)|interpro:IPR001351(Ribosomal protein S3, C-terminal)|interpro:IPR004044(K Homology, type 2)|interpro:IPR005703(Ribosomal protein S3, eukaryotic/archaeal)|interpro:IPR009019(K Homology, prokaryotic type)|interpro:IPR015946(K homology-like, alpha/beta)|go:"GO:1905053"(positive regulation of base-excision repair)|go:"GO:1990090"(cellular response to nerve growth factor stimulus)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR018280|interpro:IPR036419|mint:P62909|reactome:R-RNO-156827|reactome:R-RNO-1799339|reactome:R-RNO-6791226|reactome:R-RNO-72649|reactome:R-RNO-72689|reactome:R-RNO-72695|reactome:R-RNO-72702|reactome:R-RNO-72706|reactome:R-RNO-975956|reactome:R-RNO-975957	-	-	-	caution:"The participant EBI-349571(P68370) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919386(Q7TP47) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920972(Q5XIP9) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-916419(P11980) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919578(Q8R491) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920554(Q5U3Z7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920647(Q5U2X8) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920585(Q7TP24) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-779677(P05426) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-915744(P02454) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|agonist:Insulin was shown to increase or decrease GLUT4 protein interactions in specific cases.|comment:"Insulin decreased GLUT4 interactions with the following proteins: Q9ER30 (Sarcosin), P09527 (Rab-7), O88960 (N-ethylmaleimide sensitive), P09456 (PKA I regulatory subunit), P27881 (Hexokinase type II), P07872 (Acyl-coenzyme A oxidase), Q6DGF1 (Isocitrate dehydrogenase), Q9EQX9 (Ubiquitin-conjugating), Q63446 (Polyubiquitin), P24268 (Cathepsin D), Q91XW0 (Heat shock protein 86), Q5FVH0 (unknown), P58405 (Striatin 3), Q62667 (Major vault protein), Q66H50 (unknown), Q09167 (splicing factor), Q9JHU5 (Arfaptin 1)."|comment:"Insulin increased GLUT4 interaction with the following proteins:Q9Z1P2 (R-actinin-1), P45592 (Cofilin), Q9QXQ0 (R-actinin-4), P26473 (ADP-ribosylation factor), P26437 (ADP-ribosylation factor),   Q7TNP1 (Basigin 2), Q6P6R2 (Dihydrolipoamide dehydrogenase),   P04797 (GAPDH), Q63081 (Protein disulfide isomerase), P29457 (47 kDa heat shock protein), Q9R1J8 (Leprecan), O88638 (Putative eps protein),   Q64375 (Synaptonemal complex)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:NDPK - Interactions involving proteins containing InterPro domain IPR001564, Nucleoside diphosphate kinase, core.	taxid:10116(rat-l6)|taxid:10116(Rattus norvegicus)	-	2006/02/15	2021/11/30	rogid:PbFY2lfrty8yw40Jq7ShR7xfuV410116	rogid:f4Vh6HESE+lKZinjkJ883IG3wiY10116	intact-crc:44F3A2176D02515F|rigid:9RVm0UBcqQF4k06RGKO89Bg16Q8	false	myc tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P19357	uniprotkb:P17046	intact:EBI-915426|uniprotkb:P97900|ensembl:ENSRNOP00000023256	intact:EBI-916686|uniprotkb:F1LLX8|uniprotkb:Q6P6W1|ensembl:ENSRNOP00000000177	psi-mi:glut4_rat(display_long)|uniprotkb:Glucose transporter type 4, insulin-responsive(gene name synonym)|uniprotkb:Slc2a4(gene name)|psi-mi:Slc2a4(display_short)|uniprotkb:Glut4(gene name synonym)	psi-mi:lamp2_rat(display_long)|uniprotkb:Lysosomal membrane glycoprotein type B(gene name synonym)|uniprotkb:LGP-96(gene name synonym)|uniprotkb:LGP-110(gene name synonym)|uniprotkb:CD107 antigen-like family member B(gene name synonym)|uniprotkb:Lamp2(gene name)|psi-mi:Lamp2(display_short)|uniprotkb:Lamp-2(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Foster et al. (2006)	pubmed:16396496|mint:MINT-5218203	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-921030	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2711|refseq:NP_036883.1|refseq:XP_006246658.1|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007611"(learning or memory)|go:"GO:0007614"(short-term memory)|go:"GO:0007616"(long-term memory)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010021"(amylopectin biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031550"(positive regulation of brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044381"(glucose import in response to insulin stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046323"(glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0098694"(regulation of synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0098793"(presynapse)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002441("Glucose transporter, type 4 (GLUT4)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-189200|ensembl:ENSRNOG00000017226(gene)|ensembl:ENSRNOT00000023256(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)	rgd:2990|refseq:NP_058764.2|ensembl:ENSRNOG00000000164(gene)|ensembl:ENSRNOT00000000177(transcript)|go:"GO:0005615"(extracellular space)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005768"(endosome)|go:"GO:0005770"(late endosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0006605"(protein targeting)|go:"GO:0006914"(autophagy)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0016020"(membrane)|go:"GO:0019899"(enzyme binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030670"(phagocytic vesicle membrane)|go:"GO:0031088"(platelet dense granule membrane)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0031902"(late endosome membrane)|go:"GO:0044754"(autolysosome)|go:"GO:0046716"(muscle cell cellular homeostasis)|go:"GO:0050821"(protein stabilization)|go:"GO:0061684"(chaperone-mediated autophagy)|go:"GO:0061740"(protein targeting to lysosome involved in chaperone-mediated autophagy)|go:"GO:0061742"(chaperone-mediated autophagy translocation complex)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072594"(establishment of protein localization to organelle)|go:"GO:0097352"(autophagosome maturation)|go:"GO:0097637"(integral component of autophagosome membrane)|go:"GO:1905146"(lysosomal protein catabolic process)|go:"GO:1990836"(lysosomal matrix)|interpro:IPR002000("Lysosome-associated membrane glycoprotein (Lamp)/CD68")|interpro:IPR018134|mint:P17046|reactome:R-RNO-114608|reactome:R-RNO-6798695	-	-	-	caution:"The participant EBI-349571(P68370) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919386(Q7TP47) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920972(Q5XIP9) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-916419(P11980) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919578(Q8R491) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920554(Q5U3Z7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920647(Q5U2X8) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920585(Q7TP24) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-779677(P05426) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-915744(P02454) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|agonist:Insulin was shown to increase or decrease GLUT4 protein interactions in specific cases.|comment:"Insulin decreased GLUT4 interactions with the following proteins: Q9ER30 (Sarcosin), P09527 (Rab-7), O88960 (N-ethylmaleimide sensitive), P09456 (PKA I regulatory subunit), P27881 (Hexokinase type II), P07872 (Acyl-coenzyme A oxidase), Q6DGF1 (Isocitrate dehydrogenase), Q9EQX9 (Ubiquitin-conjugating), Q63446 (Polyubiquitin), P24268 (Cathepsin D), Q91XW0 (Heat shock protein 86), Q5FVH0 (unknown), P58405 (Striatin 3), Q62667 (Major vault protein), Q66H50 (unknown), Q09167 (splicing factor), Q9JHU5 (Arfaptin 1)."|comment:"Insulin increased GLUT4 interaction with the following proteins:Q9Z1P2 (R-actinin-1), P45592 (Cofilin), Q9QXQ0 (R-actinin-4), P26473 (ADP-ribosylation factor), P26437 (ADP-ribosylation factor),   Q7TNP1 (Basigin 2), Q6P6R2 (Dihydrolipoamide dehydrogenase),   P04797 (GAPDH), Q63081 (Protein disulfide isomerase), P29457 (47 kDa heat shock protein), Q9R1J8 (Leprecan), O88638 (Putative eps protein),   Q64375 (Synaptonemal complex)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:NDPK - Interactions involving proteins containing InterPro domain IPR001564, Nucleoside diphosphate kinase, core.	taxid:10116(rat-l6)|taxid:10116(Rattus norvegicus)	-	2006/02/15	2021/11/30	rogid:PbFY2lfrty8yw40Jq7ShR7xfuV410116	rogid:joix4CrGSiBu/eJb0/wfPM42/FE10116	intact-crc:44F3A2176D02515F|rigid:9RVm0UBcqQF4k06RGKO89Bg16Q8	false	myc tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P19357	uniprotkb:P16975	intact:EBI-915426|uniprotkb:P97900|ensembl:ENSRNOP00000023256	intact:EBI-916676|uniprotkb:O08953|uniprotkb:Q6GSZ4|ensembl:ENSRNOP00000017486	psi-mi:glut4_rat(display_long)|uniprotkb:Glucose transporter type 4, insulin-responsive(gene name synonym)|uniprotkb:Slc2a4(gene name)|psi-mi:Slc2a4(display_short)|uniprotkb:Glut4(gene name synonym)	psi-mi:sprc_rat(display_long)|uniprotkb:Secreted protein acidic and rich in cysteine(gene name synonym)|uniprotkb:Osteonectin(gene name synonym)|uniprotkb:Basement-membrane protein 40(gene name synonym)|uniprotkb:Sparc(gene name)|psi-mi:Sparc(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Foster et al. (2006)	pubmed:16396496|mint:MINT-5218203	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-921030	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2711|refseq:NP_036883.1|refseq:XP_006246658.1|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007611"(learning or memory)|go:"GO:0007614"(short-term memory)|go:"GO:0007616"(long-term memory)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010021"(amylopectin biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031550"(positive regulation of brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044381"(glucose import in response to insulin stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046323"(glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0098694"(regulation of synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0098793"(presynapse)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002441("Glucose transporter, type 4 (GLUT4)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-189200|ensembl:ENSRNOG00000017226(gene)|ensembl:ENSRNOT00000023256(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)	rgd:3742|refseq:NP_036788.1|ensembl:ENSRNOG00000012840(gene)|ensembl:ENSRNOT00000017486(transcript)|go:"GO:0001503"(ossification)|go:"GO:0001937"(negative regulation of endothelial cell proliferation)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005518"(collagen binding)|go:"GO:0005604"(basement membrane)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0007507"(heart development)|go:"GO:0009629"(response to gravity)|go:"GO:0009986"(cell surface)|go:"GO:0010288"(response to lead ion)|go:"GO:0010595"(positive regulation of endothelial cell migration)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0022604"(regulation of cell morphogenesis)|go:"GO:0030324"(lung development)|go:"GO:0031012"(extracellular matrix)|go:"GO:0031091"(platelet alpha granule)|go:"GO:0031092"(platelet alpha granule membrane)|go:"GO:0031982"(vesicle)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0033591"(response to L-ascorbic acid)|go:"GO:0034097"(response to cytokine)|go:"GO:0042060"(wound healing)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0043434"(response to peptide hormone)|go:"GO:0043473"(pigmentation)|go:"GO:0045202"(synapse)|go:"GO:0045471"(response to ethanol)|go:"GO:0046686"(response to cadmium ion)|go:"GO:0048839"(inner ear development)|go:"GO:0048856"(anatomical structure development)|go:"GO:0050807"(regulation of synapse organization)|go:"GO:0050840"(extracellular matrix binding)|go:"GO:0051384"(response to glucocorticoid)|go:"GO:0051591"(response to cAMP)|go:"GO:0051592"(response to calcium ion)|go:"GO:0060348"(bone development)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0098978"(glutamatergic synapse)|interpro:IPR001999(Osteonectin-like, conserved site)|interpro:IPR002350(Proteinase inhibitor I1, Kazal)|interpro:IPR003645(Follistatin-like, N-terminal)|interpro:IPR011992(EF-Hand type)|interpro:IPR015369(Follistatin)|interpro:IPR018247|interpro:IPR019577|interpro:IPR036058|interpro:IPR037641|reactome:R-RNO-114608|reactome:R-RNO-3000178|reactome:R-RNO-3000497|go:"GO:0016363"(nuclear matrix)	-	-	-	caution:"The participant EBI-349571(P68370) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919386(Q7TP47) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920972(Q5XIP9) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-916419(P11980) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919578(Q8R491) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920554(Q5U3Z7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920647(Q5U2X8) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920585(Q7TP24) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-779677(P05426) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-915744(P02454) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|agonist:Insulin was shown to increase or decrease GLUT4 protein interactions in specific cases.|comment:"Insulin decreased GLUT4 interactions with the following proteins: Q9ER30 (Sarcosin), P09527 (Rab-7), O88960 (N-ethylmaleimide sensitive), P09456 (PKA I regulatory subunit), P27881 (Hexokinase type II), P07872 (Acyl-coenzyme A oxidase), Q6DGF1 (Isocitrate dehydrogenase), Q9EQX9 (Ubiquitin-conjugating), Q63446 (Polyubiquitin), P24268 (Cathepsin D), Q91XW0 (Heat shock protein 86), Q5FVH0 (unknown), P58405 (Striatin 3), Q62667 (Major vault protein), Q66H50 (unknown), Q09167 (splicing factor), Q9JHU5 (Arfaptin 1)."|comment:"Insulin increased GLUT4 interaction with the following proteins:Q9Z1P2 (R-actinin-1), P45592 (Cofilin), Q9QXQ0 (R-actinin-4), P26473 (ADP-ribosylation factor), P26437 (ADP-ribosylation factor),   Q7TNP1 (Basigin 2), Q6P6R2 (Dihydrolipoamide dehydrogenase),   P04797 (GAPDH), Q63081 (Protein disulfide isomerase), P29457 (47 kDa heat shock protein), Q9R1J8 (Leprecan), O88638 (Putative eps protein),   Q64375 (Synaptonemal complex)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:NDPK - Interactions involving proteins containing InterPro domain IPR001564, Nucleoside diphosphate kinase, core.	taxid:10116(rat-l6)|taxid:10116(Rattus norvegicus)	-	2006/02/15	2021/11/30	rogid:PbFY2lfrty8yw40Jq7ShR7xfuV410116	rogid:GP+/8nyUnarlbNGGOl4tY4OlNVU10116	intact-crc:44F3A2176D02515F|rigid:9RVm0UBcqQF4k06RGKO89Bg16Q8	false	myc tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P19357	uniprotkb:P16638	intact:EBI-915426|uniprotkb:P97900|ensembl:ENSRNOP00000023256	intact:EBI-916664|uniprotkb:Q497C7|uniprotkb:Q8VIQ1	psi-mi:glut4_rat(display_long)|uniprotkb:Glucose transporter type 4, insulin-responsive(gene name synonym)|uniprotkb:Slc2a4(gene name)|psi-mi:Slc2a4(display_short)|uniprotkb:Glut4(gene name synonym)	psi-mi:acly_rat(display_long)|uniprotkb:"ATP-citrate (pro-S-)-lyase"(gene name synonym)|uniprotkb:Citrate cleavage enzyme(gene name synonym)|uniprotkb:Acly(gene name)|psi-mi:Acly(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Foster et al. (2006)	pubmed:16396496|mint:MINT-5218203	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-921030	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2711|refseq:NP_036883.1|refseq:XP_006246658.1|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007611"(learning or memory)|go:"GO:0007614"(short-term memory)|go:"GO:0007616"(long-term memory)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010021"(amylopectin biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031550"(positive regulation of brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044381"(glucose import in response to insulin stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046323"(glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0098694"(regulation of synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0098793"(presynapse)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002441("Glucose transporter, type 4 (GLUT4)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-189200|ensembl:ENSRNOG00000017226(gene)|ensembl:ENSRNOT00000023256(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)	rgd:2018|refseq:NP_001104565.1|refseq:NP_058683.2|interpro:IPR014608(ATP-citrate synthase)|reactome:R-RNO-6798695|reactome:R-RNO-75105|interpro:IPR017440(ATP-citrate lyase/succinyl-CoA ligase, active site)|interpro:IPR016143(Citrate synthase-like, small alpha subdomain)|interpro:IPR002020(Citrate synthase-like)|interpro:IPR003781(CoA-binding)|interpro:IPR005811(ATP-citrate lyase/succinyl-CoA ligase)|interpro:IPR017866|interpro:IPR016102(Succinyl-CoA synthetase-like)|interpro:IPR032263|interpro:IPR016142(Citrate synthase-like, large alpha subdomain)|interpro:IPR033847|interpro:IPR036291|interpro:IPR036969|go:"GO:0003878"(ATP citrate synthase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005829"(cytosol)|go:"GO:0006084"(acetyl-CoA metabolic process)|go:"GO:0006085"(acetyl-CoA biosynthetic process)|go:"GO:0006101"(citrate metabolic process)|go:"GO:0006107"(oxaloacetate metabolic process)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0006633"(fatty acid biosynthetic process)|go:"GO:0008610"(lipid biosynthetic process)|go:"GO:0046872"(metal ion binding)	-	-	-	caution:"The participant EBI-349571(P68370) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919386(Q7TP47) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920972(Q5XIP9) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-916419(P11980) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919578(Q8R491) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920554(Q5U3Z7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920647(Q5U2X8) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920585(Q7TP24) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-779677(P05426) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-915744(P02454) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|agonist:Insulin was shown to increase or decrease GLUT4 protein interactions in specific cases.|comment:"Insulin decreased GLUT4 interactions with the following proteins: Q9ER30 (Sarcosin), P09527 (Rab-7), O88960 (N-ethylmaleimide sensitive), P09456 (PKA I regulatory subunit), P27881 (Hexokinase type II), P07872 (Acyl-coenzyme A oxidase), Q6DGF1 (Isocitrate dehydrogenase), Q9EQX9 (Ubiquitin-conjugating), Q63446 (Polyubiquitin), P24268 (Cathepsin D), Q91XW0 (Heat shock protein 86), Q5FVH0 (unknown), P58405 (Striatin 3), Q62667 (Major vault protein), Q66H50 (unknown), Q09167 (splicing factor), Q9JHU5 (Arfaptin 1)."|comment:"Insulin increased GLUT4 interaction with the following proteins:Q9Z1P2 (R-actinin-1), P45592 (Cofilin), Q9QXQ0 (R-actinin-4), P26473 (ADP-ribosylation factor), P26437 (ADP-ribosylation factor),   Q7TNP1 (Basigin 2), Q6P6R2 (Dihydrolipoamide dehydrogenase),   P04797 (GAPDH), Q63081 (Protein disulfide isomerase), P29457 (47 kDa heat shock protein), Q9R1J8 (Leprecan), O88638 (Putative eps protein),   Q64375 (Synaptonemal complex)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:NDPK - Interactions involving proteins containing InterPro domain IPR001564, Nucleoside diphosphate kinase, core.	taxid:10116(rat-l6)|taxid:10116(Rattus norvegicus)	-	2006/02/15	2021/11/30	rogid:PbFY2lfrty8yw40Jq7ShR7xfuV410116	rogid:r0Hbx0uV2lYyeDU6jOGOg8tMXXs10116	intact-crc:44F3A2176D02515F|rigid:9RVm0UBcqQF4k06RGKO89Bg16Q8	false	myc tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P19357	uniprotkb:P62850	intact:EBI-915426|uniprotkb:P97900|ensembl:ENSRNOP00000023256	intact:EBI-354479|uniprotkb:Q6PEC9|uniprotkb:P16632	psi-mi:glut4_rat(display_long)|uniprotkb:Glucose transporter type 4, insulin-responsive(gene name synonym)|uniprotkb:Slc2a4(gene name)|psi-mi:Slc2a4(display_short)|uniprotkb:Glut4(gene name synonym)	psi-mi:rs24_rat(display_long)|uniprotkb:Rps24(gene name)|psi-mi:Rps24(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Foster et al. (2006)	pubmed:16396496|mint:MINT-5218203	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-921030	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2711|refseq:NP_036883.1|refseq:XP_006246658.1|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007611"(learning or memory)|go:"GO:0007614"(short-term memory)|go:"GO:0007616"(long-term memory)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010021"(amylopectin biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031550"(positive regulation of brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044381"(glucose import in response to insulin stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046323"(glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0098694"(regulation of synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0098793"(presynapse)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002441("Glucose transporter, type 4 (GLUT4)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-189200|ensembl:ENSRNOG00000017226(gene)|ensembl:ENSRNOT00000023256(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)	rgd:621040|refseq:NP_112374.1|interpro:IPR012678(Ribosomal protein L23/L15e, core)|interpro:IPR001976(Ribosomal protein S24e)|interpro:IPR018098|refseq:XP_006252593.1|refseq:XP_006252594.1|refseq:XP_006252595.1|go:"GO:0003735"(structural constituent of ribosome)|go:"GO:0005840"(ribosome)|go:"GO:0006364"(rRNA processing)|go:"GO:0006413"(translational initiation)|go:"GO:0015935"(small ribosomal subunit)|go:"GO:0022626"(cytosolic ribosome)|go:"GO:0022627"(cytosolic small ribosomal subunit)|go:"GO:0031369"(translation initiation factor binding)|go:"GO:0034101"(erythrocyte homeostasis)|go:"GO:0042274"(ribosomal small subunit biogenesis)|go:"GO:0097421"(liver regeneration)|reactome:R-RNO-156827|reactome:R-RNO-1799339|reactome:R-RNO-6791226|reactome:R-RNO-72649|reactome:R-RNO-72689|reactome:R-RNO-72695|reactome:R-RNO-72702|reactome:R-RNO-72706|reactome:R-RNO-975956|reactome:R-RNO-975957|mint:P62850	-	-	-	caution:"The participant EBI-349571(P68370) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919386(Q7TP47) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920972(Q5XIP9) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-916419(P11980) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919578(Q8R491) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920554(Q5U3Z7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920647(Q5U2X8) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920585(Q7TP24) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-779677(P05426) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-915744(P02454) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|agonist:Insulin was shown to increase or decrease GLUT4 protein interactions in specific cases.|comment:"Insulin decreased GLUT4 interactions with the following proteins: Q9ER30 (Sarcosin), P09527 (Rab-7), O88960 (N-ethylmaleimide sensitive), P09456 (PKA I regulatory subunit), P27881 (Hexokinase type II), P07872 (Acyl-coenzyme A oxidase), Q6DGF1 (Isocitrate dehydrogenase), Q9EQX9 (Ubiquitin-conjugating), Q63446 (Polyubiquitin), P24268 (Cathepsin D), Q91XW0 (Heat shock protein 86), Q5FVH0 (unknown), P58405 (Striatin 3), Q62667 (Major vault protein), Q66H50 (unknown), Q09167 (splicing factor), Q9JHU5 (Arfaptin 1)."|comment:"Insulin increased GLUT4 interaction with the following proteins:Q9Z1P2 (R-actinin-1), P45592 (Cofilin), Q9QXQ0 (R-actinin-4), P26473 (ADP-ribosylation factor), P26437 (ADP-ribosylation factor),   Q7TNP1 (Basigin 2), Q6P6R2 (Dihydrolipoamide dehydrogenase),   P04797 (GAPDH), Q63081 (Protein disulfide isomerase), P29457 (47 kDa heat shock protein), Q9R1J8 (Leprecan), O88638 (Putative eps protein),   Q64375 (Synaptonemal complex)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:NDPK - Interactions involving proteins containing InterPro domain IPR001564, Nucleoside diphosphate kinase, core.	taxid:10116(rat-l6)|taxid:10116(Rattus norvegicus)	-	2006/02/15	2021/11/30	rogid:PbFY2lfrty8yw40Jq7ShR7xfuV410116	rogid:M/qkRxabHx9PFaOM7EwKDOOwu7Q10116	intact-crc:44F3A2176D02515F|rigid:9RVm0UBcqQF4k06RGKO89Bg16Q8	false	myc tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P19357	uniprotkb:P16036	intact:EBI-915426|uniprotkb:P97900|ensembl:ENSRNOP00000023256	intact:EBI-916656	psi-mi:glut4_rat(display_long)|uniprotkb:Glucose transporter type 4, insulin-responsive(gene name synonym)|uniprotkb:Slc2a4(gene name)|psi-mi:Slc2a4(display_short)|uniprotkb:Glut4(gene name synonym)	psi-mi:mpcp_rat(display_long)|uniprotkb:Phosphate transport protein(gene name synonym)|uniprotkb:Solute carrier family 25 member 3(gene name synonym)|uniprotkb:Slc25a3(gene name)|psi-mi:Slc25a3(display_short)|uniprotkb:Phc(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Foster et al. (2006)	pubmed:16396496|mint:MINT-5218203	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-921030	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2711|refseq:NP_036883.1|refseq:XP_006246658.1|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007611"(learning or memory)|go:"GO:0007614"(short-term memory)|go:"GO:0007616"(long-term memory)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010021"(amylopectin biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031550"(positive regulation of brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044381"(glucose import in response to insulin stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046323"(glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0098694"(regulation of synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0098793"(presynapse)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002441("Glucose transporter, type 4 (GLUT4)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-189200|ensembl:ENSRNOG00000017226(gene)|ensembl:ENSRNOT00000023256(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)	rgd:70986|interpro:IPR018108|interpro:IPR023395|mint:P16036|interpro:IPR044677|go:"GO:0005315"(inorganic phosphate transmembrane transporter activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0015317"("phosphate:proton symporter activity")|go:"GO:0031305"(integral component of mitochondrial inner membrane)|go:"GO:0035435"(phosphate ion transmembrane transport)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:1990547"(mitochondrial phosphate ion transmembrane transport)	-	-	-	caution:"The participant EBI-349571(P68370) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919386(Q7TP47) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920972(Q5XIP9) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-916419(P11980) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919578(Q8R491) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920554(Q5U3Z7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920647(Q5U2X8) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920585(Q7TP24) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-779677(P05426) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-915744(P02454) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|agonist:Insulin was shown to increase or decrease GLUT4 protein interactions in specific cases.|comment:"Insulin decreased GLUT4 interactions with the following proteins: Q9ER30 (Sarcosin), P09527 (Rab-7), O88960 (N-ethylmaleimide sensitive), P09456 (PKA I regulatory subunit), P27881 (Hexokinase type II), P07872 (Acyl-coenzyme A oxidase), Q6DGF1 (Isocitrate dehydrogenase), Q9EQX9 (Ubiquitin-conjugating), Q63446 (Polyubiquitin), P24268 (Cathepsin D), Q91XW0 (Heat shock protein 86), Q5FVH0 (unknown), P58405 (Striatin 3), Q62667 (Major vault protein), Q66H50 (unknown), Q09167 (splicing factor), Q9JHU5 (Arfaptin 1)."|comment:"Insulin increased GLUT4 interaction with the following proteins:Q9Z1P2 (R-actinin-1), P45592 (Cofilin), Q9QXQ0 (R-actinin-4), P26473 (ADP-ribosylation factor), P26437 (ADP-ribosylation factor),   Q7TNP1 (Basigin 2), Q6P6R2 (Dihydrolipoamide dehydrogenase),   P04797 (GAPDH), Q63081 (Protein disulfide isomerase), P29457 (47 kDa heat shock protein), Q9R1J8 (Leprecan), O88638 (Putative eps protein),   Q64375 (Synaptonemal complex)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:NDPK - Interactions involving proteins containing InterPro domain IPR001564, Nucleoside diphosphate kinase, core.	taxid:10116(rat-l6)|taxid:10116(Rattus norvegicus)	-	2006/02/15	2021/11/30	rogid:PbFY2lfrty8yw40Jq7ShR7xfuV410116	rogid:BwRf4GKI4G+aBu3r29CqmCdOHyM10116	intact-crc:44F3A2176D02515F|rigid:9RVm0UBcqQF4k06RGKO89Bg16Q8	false	myc tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P19357	uniprotkb:P15999	intact:EBI-915426|uniprotkb:P97900|ensembl:ENSRNOP00000023256	intact:EBI-916646|uniprotkb:Q6P753	psi-mi:glut4_rat(display_long)|uniprotkb:Glucose transporter type 4, insulin-responsive(gene name synonym)|uniprotkb:Slc2a4(gene name)|psi-mi:Slc2a4(display_short)|uniprotkb:Glut4(gene name synonym)	psi-mi:atpa_rat(display_long)|uniprotkb:Atp5f1a(gene name)|psi-mi:Atp5f1a(display_short)|uniprotkb:ATP synthase F1 subunit alpha(gene name synonym)|uniprotkb:Atp5a1(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Foster et al. (2006)	pubmed:16396496|mint:MINT-5218203	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-921030	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2711|refseq:NP_036883.1|refseq:XP_006246658.1|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007611"(learning or memory)|go:"GO:0007614"(short-term memory)|go:"GO:0007616"(long-term memory)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010021"(amylopectin biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031550"(positive regulation of brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044381"(glucose import in response to insulin stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046323"(glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0098694"(regulation of synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0098793"(presynapse)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002441("Glucose transporter, type 4 (GLUT4)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-189200|ensembl:ENSRNOG00000017226(gene)|ensembl:ENSRNOT00000023256(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)	rgd:619993|refseq:NP_075581.1|interpro:IPR020003|interpro:IPR005294(ATPase, F1 complex, alpha subunit)|interpro:IPR023366|interpro:IPR000793(ATPase, F1/V1/A1 complex, alpha/beta subunit, C-terminal)|interpro:IPR004100(ATPase, F1/V1/A1 complex, alpha/beta subunit, N-terminal)|interpro:IPR000194(ATPase, F1/V1/A1 complex, alpha/beta subunit, nucleotide-binding)|interpro:IPR033732|interpro:IPR027417|mint:P15999|interpro:IPR038376|interpro:IPR036121|go:"GO:0000275"("mitochondrial proton-transporting ATP synthase complex, catalytic sector F(1)")|go:"GO:0001937"(negative regulation of endothelial cell proliferation)|go:"GO:0002020"(protease binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005753"(mitochondrial proton-transporting ATP synthase complex)|go:"GO:0005754"(mitochondrial proton-transporting ATP synthase, catalytic core)|go:"GO:0005886"(plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0006754"(ATP biosynthetic process)|go:"GO:0006915"(apoptotic process)|go:"GO:0007568"(aging)|go:"GO:0009986"(cell surface)|go:"GO:0014850"(response to muscle activity)|go:"GO:0015986"(ATP synthesis coupled proton transport)|go:"GO:0016020"(membrane)|go:"GO:0042288"(MHC class I protein binding)|go:"GO:0042776"(mitochondrial ATP synthesis coupled proton transport)|go:"GO:0043531"(ADP binding)|go:"GO:0043532"(angiostatin binding)|go:"GO:0043536"(positive regulation of blood vessel endothelial cell migration)|go:"GO:0045121"(membrane raft)|go:"GO:0045259"(proton-transporting ATP synthase complex)|go:"GO:0045261"("proton-transporting ATP synthase complex, catalytic core F(1)")|go:"GO:0045471"(response to ethanol)|go:"GO:0046034"(ATP metabolic process)|go:"GO:0046933"(proton-transporting ATP synthase activity, rotational mechanism)|go:"GO:0071549"(cellular response to dexamethasone stimulus)|go:"GO:0071732"(cellular response to nitric oxide)|rcsb pdb:1MAB|rcsb pdb:2F43	-	-	-	caution:"The participant EBI-349571(P68370) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919386(Q7TP47) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920972(Q5XIP9) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-916419(P11980) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919578(Q8R491) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920554(Q5U3Z7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920647(Q5U2X8) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920585(Q7TP24) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-779677(P05426) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-915744(P02454) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|agonist:Insulin was shown to increase or decrease GLUT4 protein interactions in specific cases.|comment:"Insulin decreased GLUT4 interactions with the following proteins: Q9ER30 (Sarcosin), P09527 (Rab-7), O88960 (N-ethylmaleimide sensitive), P09456 (PKA I regulatory subunit), P27881 (Hexokinase type II), P07872 (Acyl-coenzyme A oxidase), Q6DGF1 (Isocitrate dehydrogenase), Q9EQX9 (Ubiquitin-conjugating), Q63446 (Polyubiquitin), P24268 (Cathepsin D), Q91XW0 (Heat shock protein 86), Q5FVH0 (unknown), P58405 (Striatin 3), Q62667 (Major vault protein), Q66H50 (unknown), Q09167 (splicing factor), Q9JHU5 (Arfaptin 1)."|comment:"Insulin increased GLUT4 interaction with the following proteins:Q9Z1P2 (R-actinin-1), P45592 (Cofilin), Q9QXQ0 (R-actinin-4), P26473 (ADP-ribosylation factor), P26437 (ADP-ribosylation factor),   Q7TNP1 (Basigin 2), Q6P6R2 (Dihydrolipoamide dehydrogenase),   P04797 (GAPDH), Q63081 (Protein disulfide isomerase), P29457 (47 kDa heat shock protein), Q9R1J8 (Leprecan), O88638 (Putative eps protein),   Q64375 (Synaptonemal complex)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:NDPK - Interactions involving proteins containing InterPro domain IPR001564, Nucleoside diphosphate kinase, core.	taxid:10116(rat-l6)|taxid:10116(Rattus norvegicus)	-	2006/02/15	2021/11/30	rogid:PbFY2lfrty8yw40Jq7ShR7xfuV410116	rogid:Jkbhz0cHR3egHpKo/n1Ex4EbnUI10116	intact-crc:44F3A2176D02515F|rigid:9RVm0UBcqQF4k06RGKO89Bg16Q8	false	myc tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P19357	uniprotkb:P15791	intact:EBI-915426|uniprotkb:P97900|ensembl:ENSRNOP00000023256	intact:EBI-916602|uniprotkb:P97915|uniprotkb:P97916|uniprotkb:Q3B7L0|uniprotkb:Q63904|uniprotkb:Q63905|uniprotkb:Q63906|uniprotkb:Q63907|uniprotkb:Q63908|ensembl:ENSRNOP00000016026|ensembl:ENSRNOP00000062625	psi-mi:glut4_rat(display_long)|uniprotkb:Glucose transporter type 4, insulin-responsive(gene name synonym)|uniprotkb:Slc2a4(gene name)|psi-mi:Slc2a4(display_short)|uniprotkb:Glut4(gene name synonym)	psi-mi:kcc2d_rat(display_long)|uniprotkb:Camk2d(gene name)|psi-mi:Camk2d(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Foster et al. (2006)	pubmed:16396496|mint:MINT-5218203	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-921030	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2711|refseq:NP_036883.1|refseq:XP_006246658.1|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007611"(learning or memory)|go:"GO:0007614"(short-term memory)|go:"GO:0007616"(long-term memory)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010021"(amylopectin biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031550"(positive regulation of brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044381"(glucose import in response to insulin stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046323"(glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0098694"(regulation of synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0098793"(presynapse)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002441("Glucose transporter, type 4 (GLUT4)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-189200|ensembl:ENSRNOG00000017226(gene)|ensembl:ENSRNOT00000023256(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)	rgd:2263|refseq:NP_036651.1|ensembl:ENSRNOG00000011589(gene)|ensembl:ENSRNOT00000016026(transcript)|ensembl:ENSRNOT00000068198(transcript)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002028"(regulation of sodium ion transport)|go:"GO:0003254"(regulation of membrane depolarization)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004683"(calmodulin-dependent protein kinase activity)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005954"(calcium- and calmodulin-dependent protein kinase complex)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006816"(calcium ion transport)|go:"GO:0010613"(positive regulation of cardiac muscle hypertrophy)|go:"GO:0010649"(regulation of cell communication by electrical coupling)|go:"GO:0010666"(positive regulation of cardiac muscle cell apoptotic process)|go:"GO:0010880"(regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum)|go:"GO:0010881"(regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion)|go:"GO:0010971"(positive regulation of G2/M transition of mitotic cell cycle)|go:"GO:2000573"(positive regulation of DNA biosynthetic process)|go:"GO:0014704"(intercalated disc)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0019871"(sodium channel inhibitor activity)|go:"GO:0030007"(cellular potassium ion homeostasis)|go:"GO:0030315"(T-tubule)|go:"GO:0031432"(titin binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0032469"(endoplasmic reticulum calcium ion homeostasis)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033017"(sarcoplasmic reticulum membrane)|go:"GO:0035022"(positive regulation of Rac protein signal transduction)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043194"(axon initial segment)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050998"(nitric-oxide synthase binding)|go:"GO:0055119"(relaxation of cardiac muscle)|go:"GO:0060048"(cardiac muscle contraction)|go:"GO:0060341"(regulation of cellular localization)|go:"GO:0061049"(cell growth involved in cardiac muscle cell development)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0086003"(cardiac muscle cell contraction)|go:"GO:0098901"(regulation of cardiac muscle cell action potential)|go:"GO:0098909"(regulation of cardiac muscle cell action potential involved in regulation of contraction)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1901844"(regulation of cell communication by electrical coupling involved in cardiac conduction)|go:"GO:1901897"(regulation of relaxation of cardiac muscle)|go:"GO:1902306"(negative regulation of sodium ion transmembrane transport)|go:"GO:1902514"(regulation of calcium ion transmembrane transport via high voltage-gated calcium channel)|go:"GO:1903076"(regulation of protein localization to plasma membrane)|go:"GO:1904707"(positive regulation of vascular associated smooth muscle cell proliferation)|refseq:XP_017446093.1|refseq:XP_017446094.1|refseq:XP_017446095.1|refseq:XP_017446099.1|refseq:XP_017446100.1|refseq:XP_017446102.1|refseq:XP_017446106.1|reactome:R-RNO-5576892|reactome:R-RNO-5578775|reactome:R-RNO-5673000|reactome:R-RNO-5673001|reactome:R-RNO-877300|reactome:R-RNO-936837|go:"GO:2000650"(negative regulation of sodium ion transmembrane transporter activity)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR013543(Calcium/calmodulin dependent protein kinase II, association-domain)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR032710|mint:P15791|reactome:R-RNO-3371571|reactome:R-RNO-399719|reactome:R-RNO-438066	-	-	-	caution:"The participant EBI-349571(P68370) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919386(Q7TP47) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920972(Q5XIP9) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-916419(P11980) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919578(Q8R491) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920554(Q5U3Z7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920647(Q5U2X8) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920585(Q7TP24) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-779677(P05426) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-915744(P02454) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|agonist:Insulin was shown to increase or decrease GLUT4 protein interactions in specific cases.|comment:"Insulin decreased GLUT4 interactions with the following proteins: Q9ER30 (Sarcosin), P09527 (Rab-7), O88960 (N-ethylmaleimide sensitive), P09456 (PKA I regulatory subunit), P27881 (Hexokinase type II), P07872 (Acyl-coenzyme A oxidase), Q6DGF1 (Isocitrate dehydrogenase), Q9EQX9 (Ubiquitin-conjugating), Q63446 (Polyubiquitin), P24268 (Cathepsin D), Q91XW0 (Heat shock protein 86), Q5FVH0 (unknown), P58405 (Striatin 3), Q62667 (Major vault protein), Q66H50 (unknown), Q09167 (splicing factor), Q9JHU5 (Arfaptin 1)."|comment:"Insulin increased GLUT4 interaction with the following proteins:Q9Z1P2 (R-actinin-1), P45592 (Cofilin), Q9QXQ0 (R-actinin-4), P26473 (ADP-ribosylation factor), P26437 (ADP-ribosylation factor),   Q7TNP1 (Basigin 2), Q6P6R2 (Dihydrolipoamide dehydrogenase),   P04797 (GAPDH), Q63081 (Protein disulfide isomerase), P29457 (47 kDa heat shock protein), Q9R1J8 (Leprecan), O88638 (Putative eps protein),   Q64375 (Synaptonemal complex)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:NDPK - Interactions involving proteins containing InterPro domain IPR001564, Nucleoside diphosphate kinase, core.	taxid:10116(rat-l6)|taxid:10116(Rattus norvegicus)	-	2006/02/15	2021/11/30	rogid:PbFY2lfrty8yw40Jq7ShR7xfuV410116	rogid:DrskswXp/QJHvHXeG0tWWxxV2K810116	intact-crc:44F3A2176D02515F|rigid:9RVm0UBcqQF4k06RGKO89Bg16Q8	false	myc tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P19357	uniprotkb:P15651	intact:EBI-915426|uniprotkb:P97900|ensembl:ENSRNOP00000023256	intact:EBI-916589	psi-mi:glut4_rat(display_long)|uniprotkb:Glucose transporter type 4, insulin-responsive(gene name synonym)|uniprotkb:Slc2a4(gene name)|psi-mi:Slc2a4(display_short)|uniprotkb:Glut4(gene name synonym)	psi-mi:acads_rat(display_long)|uniprotkb:Butyryl-CoA dehydrogenase(gene name synonym)|uniprotkb:Acads(gene name)|psi-mi:Acads(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Foster et al. (2006)	pubmed:16396496|mint:MINT-5218203	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-921030	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2711|refseq:NP_036883.1|refseq:XP_006246658.1|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007611"(learning or memory)|go:"GO:0007614"(short-term memory)|go:"GO:0007616"(long-term memory)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010021"(amylopectin biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031550"(positive regulation of brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044381"(glucose import in response to insulin stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046323"(glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0098694"(regulation of synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0098793"(presynapse)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002441("Glucose transporter, type 4 (GLUT4)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-189200|ensembl:ENSRNOG00000017226(gene)|ensembl:ENSRNOT00000023256(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)	go:"GO:0000062"(fatty-acyl-CoA binding)|go:"GO:0003995"(acyl-CoA dehydrogenase activity)|go:"GO:0004085"(butyryl-CoA dehydrogenase activity)|go:"GO:0005739"(mitochondrion)|rgd:620514|refseq:NP_071957.1|interpro:IPR006089(Acyl-CoA dehydrogenase, conserved site)|interpro:IPR006091(Acyl-CoA dehydrogenase/oxidase, central region)|interpro:IPR009075(Acyl-CoA dehydrogenase/oxidase C-terminal)|interpro:IPR013786(Acyl-CoA dehydrogenase/oxidase, N-terminal)|interpro:IPR009100(Acyl-CoA dehydrogenase/oxidase, middle and N-terminal)|rcsb pdb:1JQI|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0006635"(fatty acid beta-oxidation)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0033539"(fatty acid beta-oxidation using acyl-CoA dehydrogenase)|go:"GO:0042594"(response to starvation)|go:"GO:0042802"(identical protein binding)|go:"GO:0046359"(butyrate catabolic process)|go:"GO:0050660"(flavin adenine dinucleotide binding)|go:"GO:0051384"(response to glucocorticoid)|reactome:R-RNO-77352|interpro:IPR036250|interpro:IPR037069|reactome:R-RNO-77350	-	-	-	caution:"The participant EBI-349571(P68370) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919386(Q7TP47) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920972(Q5XIP9) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-916419(P11980) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919578(Q8R491) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920554(Q5U3Z7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920647(Q5U2X8) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920585(Q7TP24) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-779677(P05426) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-915744(P02454) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|agonist:Insulin was shown to increase or decrease GLUT4 protein interactions in specific cases.|comment:"Insulin decreased GLUT4 interactions with the following proteins: Q9ER30 (Sarcosin), P09527 (Rab-7), O88960 (N-ethylmaleimide sensitive), P09456 (PKA I regulatory subunit), P27881 (Hexokinase type II), P07872 (Acyl-coenzyme A oxidase), Q6DGF1 (Isocitrate dehydrogenase), Q9EQX9 (Ubiquitin-conjugating), Q63446 (Polyubiquitin), P24268 (Cathepsin D), Q91XW0 (Heat shock protein 86), Q5FVH0 (unknown), P58405 (Striatin 3), Q62667 (Major vault protein), Q66H50 (unknown), Q09167 (splicing factor), Q9JHU5 (Arfaptin 1)."|comment:"Insulin increased GLUT4 interaction with the following proteins:Q9Z1P2 (R-actinin-1), P45592 (Cofilin), Q9QXQ0 (R-actinin-4), P26473 (ADP-ribosylation factor), P26437 (ADP-ribosylation factor),   Q7TNP1 (Basigin 2), Q6P6R2 (Dihydrolipoamide dehydrogenase),   P04797 (GAPDH), Q63081 (Protein disulfide isomerase), P29457 (47 kDa heat shock protein), Q9R1J8 (Leprecan), O88638 (Putative eps protein),   Q64375 (Synaptonemal complex)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:NDPK - Interactions involving proteins containing InterPro domain IPR001564, Nucleoside diphosphate kinase, core.	taxid:10116(rat-l6)|taxid:10116(Rattus norvegicus)	-	2006/02/15	2021/11/30	rogid:PbFY2lfrty8yw40Jq7ShR7xfuV410116	rogid:mNAq+7WbN4s5b9ygc2bKfdZ8zqA10116	intact-crc:44F3A2176D02515F|rigid:9RVm0UBcqQF4k06RGKO89Bg16Q8	false	myc tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P19357	uniprotkb:P15178	intact:EBI-915426|uniprotkb:P97900|ensembl:ENSRNOP00000023256	intact:EBI-916576|ensembl:ENSRNOP00000005127	psi-mi:glut4_rat(display_long)|uniprotkb:Glucose transporter type 4, insulin-responsive(gene name synonym)|uniprotkb:Slc2a4(gene name)|psi-mi:Slc2a4(display_short)|uniprotkb:Glut4(gene name synonym)	psi-mi:sydc_rat(display_long)|uniprotkb:Dars1(gene name)|psi-mi:Dars1(display_short)|uniprotkb:Aspartyl-tRNA synthetase(gene name synonym)|uniprotkb:Dars(gene name synonym)|uniprotkb:Drs1(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Foster et al. (2006)	pubmed:16396496|mint:MINT-5218203	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-921030	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2711|refseq:NP_036883.1|refseq:XP_006246658.1|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007611"(learning or memory)|go:"GO:0007614"(short-term memory)|go:"GO:0007616"(long-term memory)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010021"(amylopectin biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031550"(positive regulation of brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044381"(glucose import in response to insulin stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046323"(glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0098694"(regulation of synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0098793"(presynapse)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002441("Glucose transporter, type 4 (GLUT4)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-189200|ensembl:ENSRNOG00000017226(gene)|ensembl:ENSRNOT00000023256(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)	mint:P15178|ensembl:ENSRNOG00000003743(gene)|ensembl:ENSRNOT00000005127(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0004815"(aspartate-tRNA ligase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006422"(aspartyl-tRNA aminoacylation)|go:"GO:0017101"(aminoacyl-tRNA synthetase multienzyme complex)|go:"GO:0045202"(synapse)|interpro:IPR002312(Aspartyl-tRNA synthetase, class IIb)|interpro:IPR004364("Aminoacyl-tRNA synthetase, class II (D, K and N)")|interpro:IPR004365(Nucleic acid binding, OB-fold, tRNA/helicase-type)|interpro:IPR004523(Aspartyl-tRNA synthetase, class IIb, archea/euk type)|interpro:IPR006195(Aminoacyl-tRNA synthetase, class II)|interpro:IPR012340(Nucleic acid-binding, OB-fold)|rgd:621167|refseq:NP_446251.1	-	-	-	caution:"The participant EBI-349571(P68370) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919386(Q7TP47) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920972(Q5XIP9) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-916419(P11980) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919578(Q8R491) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920554(Q5U3Z7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920647(Q5U2X8) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920585(Q7TP24) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-779677(P05426) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-915744(P02454) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|agonist:Insulin was shown to increase or decrease GLUT4 protein interactions in specific cases.|comment:"Insulin decreased GLUT4 interactions with the following proteins: Q9ER30 (Sarcosin), P09527 (Rab-7), O88960 (N-ethylmaleimide sensitive), P09456 (PKA I regulatory subunit), P27881 (Hexokinase type II), P07872 (Acyl-coenzyme A oxidase), Q6DGF1 (Isocitrate dehydrogenase), Q9EQX9 (Ubiquitin-conjugating), Q63446 (Polyubiquitin), P24268 (Cathepsin D), Q91XW0 (Heat shock protein 86), Q5FVH0 (unknown), P58405 (Striatin 3), Q62667 (Major vault protein), Q66H50 (unknown), Q09167 (splicing factor), Q9JHU5 (Arfaptin 1)."|comment:"Insulin increased GLUT4 interaction with the following proteins:Q9Z1P2 (R-actinin-1), P45592 (Cofilin), Q9QXQ0 (R-actinin-4), P26473 (ADP-ribosylation factor), P26437 (ADP-ribosylation factor),   Q7TNP1 (Basigin 2), Q6P6R2 (Dihydrolipoamide dehydrogenase),   P04797 (GAPDH), Q63081 (Protein disulfide isomerase), P29457 (47 kDa heat shock protein), Q9R1J8 (Leprecan), O88638 (Putative eps protein),   Q64375 (Synaptonemal complex)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:NDPK - Interactions involving proteins containing InterPro domain IPR001564, Nucleoside diphosphate kinase, core.	taxid:10116(rat-l6)|taxid:10116(Rattus norvegicus)	-	2006/02/15	2021/11/30	rogid:PbFY2lfrty8yw40Jq7ShR7xfuV410116	rogid:NGlGimpuRwgUtRYpEf4re1yGHno10116	intact-crc:44F3A2176D02515F|rigid:9RVm0UBcqQF4k06RGKO89Bg16Q8	false	myc tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P19357	uniprotkb:P14604	intact:EBI-915426|uniprotkb:P97900|ensembl:ENSRNOP00000023256	intact:EBI-916569|ensembl:ENSRNOP00000025446|ensembl:ENSRNOP00000066388	psi-mi:glut4_rat(display_long)|uniprotkb:Glucose transporter type 4, insulin-responsive(gene name synonym)|uniprotkb:Slc2a4(gene name)|psi-mi:Slc2a4(display_short)|uniprotkb:Glut4(gene name synonym)	psi-mi:echm_rat(display_long)|uniprotkb:Short-chain enoyl-CoA hydratase(gene name synonym)|uniprotkb:Enoyl-CoA hydratase 1(gene name synonym)|uniprotkb:Echs1(gene name)|psi-mi:Echs1(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Foster et al. (2006)	pubmed:16396496|mint:MINT-5218203	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-921030	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2711|refseq:NP_036883.1|refseq:XP_006246658.1|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007611"(learning or memory)|go:"GO:0007614"(short-term memory)|go:"GO:0007616"(long-term memory)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010021"(amylopectin biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031550"(positive regulation of brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044381"(glucose import in response to insulin stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046323"(glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0098694"(regulation of synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0098793"(presynapse)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002441("Glucose transporter, type 4 (GLUT4)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-189200|ensembl:ENSRNOG00000017226(gene)|ensembl:ENSRNOT00000023256(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)	rgd:69330|refseq:NP_511178.1|refseq:XP_003748934.1|go:"GO:0004300"(enoyl-CoA hydratase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0006635"(fatty acid beta-oxidation)|go:"GO:0043956"(3-hydroxypropionyl-CoA dehydratase activity)|go:"GO:0120092"(crotonyl-CoA hydratase activity)|interpro:IPR001753(Crotonase, core)|interpro:IPR014748(Crontonase, C-terminal)|interpro:IPR018376|interpro:IPR029045|rcsb pdb:1DUB|rcsb pdb:1EY3|rcsb pdb:1MJ3|rcsb pdb:2DUB|reactome:R-RNO-70895|reactome:R-RNO-77310|reactome:R-RNO-77346|reactome:R-RNO-77348|reactome:R-RNO-77350|reactome:R-RNO-77352|ensembl:ENSRNOG00000018522(gene)|ensembl:ENSRNOG00000047565(gene)|ensembl:ENSRNOT00000025446(transcript)|ensembl:ENSRNOT00000071574(transcript)	-	-	-	caution:"The participant EBI-349571(P68370) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919386(Q7TP47) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920972(Q5XIP9) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-916419(P11980) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919578(Q8R491) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920554(Q5U3Z7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920647(Q5U2X8) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920585(Q7TP24) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-779677(P05426) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-915744(P02454) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|agonist:Insulin was shown to increase or decrease GLUT4 protein interactions in specific cases.|comment:"Insulin decreased GLUT4 interactions with the following proteins: Q9ER30 (Sarcosin), P09527 (Rab-7), O88960 (N-ethylmaleimide sensitive), P09456 (PKA I regulatory subunit), P27881 (Hexokinase type II), P07872 (Acyl-coenzyme A oxidase), Q6DGF1 (Isocitrate dehydrogenase), Q9EQX9 (Ubiquitin-conjugating), Q63446 (Polyubiquitin), P24268 (Cathepsin D), Q91XW0 (Heat shock protein 86), Q5FVH0 (unknown), P58405 (Striatin 3), Q62667 (Major vault protein), Q66H50 (unknown), Q09167 (splicing factor), Q9JHU5 (Arfaptin 1)."|comment:"Insulin increased GLUT4 interaction with the following proteins:Q9Z1P2 (R-actinin-1), P45592 (Cofilin), Q9QXQ0 (R-actinin-4), P26473 (ADP-ribosylation factor), P26437 (ADP-ribosylation factor),   Q7TNP1 (Basigin 2), Q6P6R2 (Dihydrolipoamide dehydrogenase),   P04797 (GAPDH), Q63081 (Protein disulfide isomerase), P29457 (47 kDa heat shock protein), Q9R1J8 (Leprecan), O88638 (Putative eps protein),   Q64375 (Synaptonemal complex)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:NDPK - Interactions involving proteins containing InterPro domain IPR001564, Nucleoside diphosphate kinase, core.	taxid:10116(rat-l6)|taxid:10116(Rattus norvegicus)	-	2006/02/15	2021/11/30	rogid:PbFY2lfrty8yw40Jq7ShR7xfuV410116	rogid:pBbWy+FP0XCgCZLn0xuAiPUF5Bs10116	intact-crc:44F3A2176D02515F|rigid:9RVm0UBcqQF4k06RGKO89Bg16Q8	false	myc tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P19357	uniprotkb:P14562	intact:EBI-915426|uniprotkb:P97900|ensembl:ENSRNOP00000023256	intact:EBI-916562|uniprotkb:P97620|ensembl:ENSRNOP00000026580	psi-mi:glut4_rat(display_long)|uniprotkb:Glucose transporter type 4, insulin-responsive(gene name synonym)|uniprotkb:Slc2a4(gene name)|psi-mi:Slc2a4(display_short)|uniprotkb:Glut4(gene name synonym)	psi-mi:lamp1_rat(display_long)|uniprotkb:120 kDa lysosomal membrane glycoprotein(gene name synonym)|uniprotkb:CD107 antigen-like family member A(gene name synonym)|uniprotkb:Lamp1(gene name)|psi-mi:Lamp1(display_short)|uniprotkb:Lamp-1(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Foster et al. (2006)	pubmed:16396496|mint:MINT-5218203	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-921030	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2711|refseq:NP_036883.1|refseq:XP_006246658.1|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007611"(learning or memory)|go:"GO:0007614"(short-term memory)|go:"GO:0007616"(long-term memory)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010021"(amylopectin biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031550"(positive regulation of brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044381"(glucose import in response to insulin stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046323"(glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0098694"(regulation of synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0098793"(presynapse)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002441("Glucose transporter, type 4 (GLUT4)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-189200|ensembl:ENSRNOG00000017226(gene)|ensembl:ENSRNOT00000023256(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)	rgd:2989|refseq:NP_036989.1|ensembl:ENSRNOG00000019629(gene)|ensembl:ENSRNOT00000026580(transcript)|go:"GO:0000421"(autophagosome membrane)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005768"(endosome)|go:"GO:0005770"(late endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005773"(vacuole)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010008"(endosome membrane)|go:"GO:0019899"(enzyme binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030285"(integral component of synaptic vesicle membrane)|go:"GO:0030425"(dendrite)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031902"(late endosome membrane)|go:"GO:0031982"(vesicle)|go:"GO:0042383"(sarcolemma)|go:"GO:0042470"(melanosome)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043323"(positive regulation of natural killer cell degranulation)|go:"GO:0044194"(cytolytic granule)|go:"GO:0044754"(autolysosome)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0045954"(positive regulation of natural killer cell mediated cytotoxicity)|go:"GO:0048102"(autophagic cell death)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050821"(protein stabilization)|go:"GO:0061474"(phagolysosome membrane)|go:"GO:0072594"(establishment of protein localization to organelle)|go:"GO:0090160"(Golgi to lysosome transport)|go:"GO:0097208"(alveolar lamellar body)|go:"GO:0101004"(cytolytic granule membrane)|go:"GO:0140507"(granzyme-mediated programmed cell death signaling pathway)|go:"GO:1902513"(regulation of organelle transport along microtubule)|interpro:IPR002000("Lysosome-associated membrane glycoprotein (Lamp)/CD68")|interpro:IPR018134|reactome:R-RNO-6798695|refseq:XP_017455483.1	-	-	-	caution:"The participant EBI-349571(P68370) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919386(Q7TP47) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920972(Q5XIP9) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-916419(P11980) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919578(Q8R491) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920554(Q5U3Z7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920647(Q5U2X8) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920585(Q7TP24) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-779677(P05426) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-915744(P02454) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|agonist:Insulin was shown to increase or decrease GLUT4 protein interactions in specific cases.|comment:"Insulin decreased GLUT4 interactions with the following proteins: Q9ER30 (Sarcosin), P09527 (Rab-7), O88960 (N-ethylmaleimide sensitive), P09456 (PKA I regulatory subunit), P27881 (Hexokinase type II), P07872 (Acyl-coenzyme A oxidase), Q6DGF1 (Isocitrate dehydrogenase), Q9EQX9 (Ubiquitin-conjugating), Q63446 (Polyubiquitin), P24268 (Cathepsin D), Q91XW0 (Heat shock protein 86), Q5FVH0 (unknown), P58405 (Striatin 3), Q62667 (Major vault protein), Q66H50 (unknown), Q09167 (splicing factor), Q9JHU5 (Arfaptin 1)."|comment:"Insulin increased GLUT4 interaction with the following proteins:Q9Z1P2 (R-actinin-1), P45592 (Cofilin), Q9QXQ0 (R-actinin-4), P26473 (ADP-ribosylation factor), P26437 (ADP-ribosylation factor),   Q7TNP1 (Basigin 2), Q6P6R2 (Dihydrolipoamide dehydrogenase),   P04797 (GAPDH), Q63081 (Protein disulfide isomerase), P29457 (47 kDa heat shock protein), Q9R1J8 (Leprecan), O88638 (Putative eps protein),   Q64375 (Synaptonemal complex)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:NDPK - Interactions involving proteins containing InterPro domain IPR001564, Nucleoside diphosphate kinase, core.	taxid:10116(rat-l6)|taxid:10116(Rattus norvegicus)	-	2006/02/15	2021/11/30	rogid:PbFY2lfrty8yw40Jq7ShR7xfuV410116	rogid:2mCfYIdewLVD+Tur5waxSU9muhE10116	intact-crc:44F3A2176D02515F|rigid:9RVm0UBcqQF4k06RGKO89Bg16Q8	false	myc tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P19357	uniprotkb:P14408	intact:EBI-915426|uniprotkb:P97900|ensembl:ENSRNOP00000023256	intact:EBI-916553|ensembl:ENSRNOP00000004917|intact:EBI-2255872|uniprotkb:Q5M964	psi-mi:glut4_rat(display_long)|uniprotkb:Glucose transporter type 4, insulin-responsive(gene name synonym)|uniprotkb:Slc2a4(gene name)|psi-mi:Slc2a4(display_short)|uniprotkb:Glut4(gene name synonym)	psi-mi:fumh_rat(display_long)|uniprotkb:Fh(gene name)|psi-mi:Fh(display_short)|uniprotkb:Fh1(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Foster et al. (2006)	pubmed:16396496|mint:MINT-5218203	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-921030	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2711|refseq:NP_036883.1|refseq:XP_006246658.1|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007611"(learning or memory)|go:"GO:0007614"(short-term memory)|go:"GO:0007616"(long-term memory)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010021"(amylopectin biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031550"(positive regulation of brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044381"(glucose import in response to insulin stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046323"(glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0098694"(regulation of synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0098793"(presynapse)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002441("Glucose transporter, type 4 (GLUT4)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-189200|ensembl:ENSRNOG00000017226(gene)|ensembl:ENSRNOT00000023256(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)	rgd:2614|ensembl:ENSRNOT00000004917(transcript)|go:"GO:0000050"(urea cycle)|go:"GO:0000415"(negative regulation of histone H3-K36 methylation)|go:"GO:0000821"(regulation of arginine metabolic process)|go:"GO:0004333"(fumarate hydratase activity)|ensembl:ENSRNOG00000003653(gene)|go:"GO:0005634"(nucleus)|go:"GO:0005694"(chromosome)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006099"(tricarboxylic acid cycle)|go:"GO:0006106"(fumarate metabolic process)|go:"GO:0006108"(malate metabolic process)|go:"GO:0006281"(DNA repair)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0045239"(tricarboxylic acid cycle enzyme complex)|go:"GO:0048873"(homeostasis of number of cells within a tissue)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:2001034"(positive regulation of double-strand break repair via nonhomologous end joining)|interpro:IPR000362(Fumarate lyase)|interpro:IPR005677(Fumarate hydratase, class II)|interpro:IPR008948(L-Aspartase-like)|interpro:IPR018951|interpro:IPR020557|interpro:IPR022761|interpro:IPR024083|reactome:R-RNO-71403|refseq:NP_058701.2	-	-	-	caution:"The participant EBI-349571(P68370) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919386(Q7TP47) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920972(Q5XIP9) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-916419(P11980) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919578(Q8R491) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920554(Q5U3Z7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920647(Q5U2X8) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920585(Q7TP24) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-779677(P05426) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-915744(P02454) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|agonist:Insulin was shown to increase or decrease GLUT4 protein interactions in specific cases.|comment:"Insulin decreased GLUT4 interactions with the following proteins: Q9ER30 (Sarcosin), P09527 (Rab-7), O88960 (N-ethylmaleimide sensitive), P09456 (PKA I regulatory subunit), P27881 (Hexokinase type II), P07872 (Acyl-coenzyme A oxidase), Q6DGF1 (Isocitrate dehydrogenase), Q9EQX9 (Ubiquitin-conjugating), Q63446 (Polyubiquitin), P24268 (Cathepsin D), Q91XW0 (Heat shock protein 86), Q5FVH0 (unknown), P58405 (Striatin 3), Q62667 (Major vault protein), Q66H50 (unknown), Q09167 (splicing factor), Q9JHU5 (Arfaptin 1)."|comment:"Insulin increased GLUT4 interaction with the following proteins:Q9Z1P2 (R-actinin-1), P45592 (Cofilin), Q9QXQ0 (R-actinin-4), P26473 (ADP-ribosylation factor), P26437 (ADP-ribosylation factor),   Q7TNP1 (Basigin 2), Q6P6R2 (Dihydrolipoamide dehydrogenase),   P04797 (GAPDH), Q63081 (Protein disulfide isomerase), P29457 (47 kDa heat shock protein), Q9R1J8 (Leprecan), O88638 (Putative eps protein),   Q64375 (Synaptonemal complex)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:NDPK - Interactions involving proteins containing InterPro domain IPR001564, Nucleoside diphosphate kinase, core.	taxid:10116(rat-l6)|taxid:10116(Rattus norvegicus)	-	2006/02/15	2021/11/30	rogid:PbFY2lfrty8yw40Jq7ShR7xfuV410116	rogid:UtB1IzVZ3d+kXpOzyoYLIrNaT4k10116	intact-crc:44F3A2176D02515F|rigid:9RVm0UBcqQF4k06RGKO89Bg16Q8	false	myc tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P19357	uniprotkb:P84100	intact:EBI-915426|uniprotkb:P97900|ensembl:ENSRNOP00000023256	intact:EBI-916546|uniprotkb:P14118|uniprotkb:P22908|ensembl:ENSRNOP00000006359	psi-mi:glut4_rat(display_long)|uniprotkb:Glucose transporter type 4, insulin-responsive(gene name synonym)|uniprotkb:Slc2a4(gene name)|psi-mi:Slc2a4(display_short)|uniprotkb:Glut4(gene name synonym)	psi-mi:rl19_rat(display_long)|uniprotkb:Rpl19(gene name)|psi-mi:Rpl19(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Foster et al. (2006)	pubmed:16396496|mint:MINT-5218203	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-921030	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2711|refseq:NP_036883.1|refseq:XP_006246658.1|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007611"(learning or memory)|go:"GO:0007614"(short-term memory)|go:"GO:0007616"(long-term memory)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010021"(amylopectin biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031550"(positive regulation of brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044381"(glucose import in response to insulin stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046323"(glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0098694"(regulation of synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0098793"(presynapse)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002441("Glucose transporter, type 4 (GLUT4)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-189200|ensembl:ENSRNOG00000017226(gene)|ensembl:ENSRNOT00000023256(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)	rgd:621183|refseq:NP_112365.1|ensembl:ENSRNOG00000004741(gene)|ensembl:ENSRNOT00000006359(transcript)|go:"GO:0002181"(cytoplasmic translation)|go:"GO:0003723"(RNA binding)|go:"GO:0003735"(structural constituent of ribosome)|go:"GO:0005730"(nucleolus)|go:"GO:0022625"(cytosolic large ribosomal subunit)|go:"GO:0022626"(cytosolic ribosome)|go:"GO:0042788"(polysomal ribosome)|go:"GO:0045202"(synapse)|go:"GO:0070180"(large ribosomal subunit rRNA binding)|go:"GO:0097421"(liver regeneration)|go:"GO:1990932"(5.8S rRNA binding)|interpro:IPR000196(Ribosomal protein L19/L19e)|interpro:IPR015972(Ribosomal protein L19/L19e, domain 1)|interpro:IPR023638|interpro:IPR033935|interpro:IPR035970|interpro:IPR039547|reactome:R-RNO-156827|reactome:R-RNO-1799339|reactome:R-RNO-6791226|reactome:R-RNO-72689|reactome:R-RNO-72706|reactome:R-RNO-975956|reactome:R-RNO-975957	-	-	-	caution:"The participant EBI-349571(P68370) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919386(Q7TP47) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920972(Q5XIP9) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-916419(P11980) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919578(Q8R491) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920554(Q5U3Z7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920647(Q5U2X8) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920585(Q7TP24) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-779677(P05426) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-915744(P02454) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|agonist:Insulin was shown to increase or decrease GLUT4 protein interactions in specific cases.|comment:"Insulin decreased GLUT4 interactions with the following proteins: Q9ER30 (Sarcosin), P09527 (Rab-7), O88960 (N-ethylmaleimide sensitive), P09456 (PKA I regulatory subunit), P27881 (Hexokinase type II), P07872 (Acyl-coenzyme A oxidase), Q6DGF1 (Isocitrate dehydrogenase), Q9EQX9 (Ubiquitin-conjugating), Q63446 (Polyubiquitin), P24268 (Cathepsin D), Q91XW0 (Heat shock protein 86), Q5FVH0 (unknown), P58405 (Striatin 3), Q62667 (Major vault protein), Q66H50 (unknown), Q09167 (splicing factor), Q9JHU5 (Arfaptin 1)."|comment:"Insulin increased GLUT4 interaction with the following proteins:Q9Z1P2 (R-actinin-1), P45592 (Cofilin), Q9QXQ0 (R-actinin-4), P26473 (ADP-ribosylation factor), P26437 (ADP-ribosylation factor),   Q7TNP1 (Basigin 2), Q6P6R2 (Dihydrolipoamide dehydrogenase),   P04797 (GAPDH), Q63081 (Protein disulfide isomerase), P29457 (47 kDa heat shock protein), Q9R1J8 (Leprecan), O88638 (Putative eps protein),   Q64375 (Synaptonemal complex)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:NDPK - Interactions involving proteins containing InterPro domain IPR001564, Nucleoside diphosphate kinase, core.	taxid:10116(rat-l6)|taxid:10116(Rattus norvegicus)	-	2006/02/15	2021/11/30	rogid:PbFY2lfrty8yw40Jq7ShR7xfuV410116	rogid:sYEwdB8ySbxh3iL0uqlfRRVFiWw10116	intact-crc:44F3A2176D02515F|rigid:9RVm0UBcqQF4k06RGKO89Bg16Q8	false	myc tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P19357	uniprotkb:P13803	intact:EBI-915426|uniprotkb:P97900|ensembl:ENSRNOP00000023256	intact:EBI-916518|uniprotkb:Q5M7W0|ensembl:ENSRNOP00000020544	psi-mi:glut4_rat(display_long)|uniprotkb:Glucose transporter type 4, insulin-responsive(gene name synonym)|uniprotkb:Slc2a4(gene name)|psi-mi:Slc2a4(display_short)|uniprotkb:Glut4(gene name synonym)	psi-mi:etfa_rat(display_long)|uniprotkb:Etfa(gene name)|psi-mi:Etfa(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Foster et al. (2006)	pubmed:16396496|mint:MINT-5218203	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-921030	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2711|refseq:NP_036883.1|refseq:XP_006246658.1|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007611"(learning or memory)|go:"GO:0007614"(short-term memory)|go:"GO:0007616"(long-term memory)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010021"(amylopectin biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031550"(positive regulation of brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044381"(glucose import in response to insulin stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046323"(glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0098694"(regulation of synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0098793"(presynapse)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002441("Glucose transporter, type 4 (GLUT4)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-189200|ensembl:ENSRNOG00000017226(gene)|ensembl:ENSRNOT00000023256(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)	rgd:628747|refseq:NP_001009668.1|ensembl:ENSRNOG00000015233(gene)|ensembl:ENSRNOT00000020544(transcript)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0009055"(electron transfer activity)|go:"GO:0016491"(oxidoreductase activity)|go:"GO:0033539"(fatty acid beta-oxidation using acyl-CoA dehydrogenase)|go:"GO:0050660"(flavin adenine dinucleotide binding)|interpro:IPR001308(Electron transfer flavoprotein, alpha subunit)|interpro:IPR014729(Rossmann-like alpha/beta/alpha sandwich fold)|interpro:IPR014730(Electron transfer flavoprotein, alpha/beta-subunit, N-terminal)|interpro:IPR014731(Electron transfer flavoprotein, alpha subunit, C-terminal)|interpro:IPR018206|interpro:IPR029035|interpro:IPR033947|reactome:R-RNO-611105	-	-	-	caution:"The participant EBI-349571(P68370) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919386(Q7TP47) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920972(Q5XIP9) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-916419(P11980) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919578(Q8R491) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920554(Q5U3Z7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920647(Q5U2X8) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920585(Q7TP24) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-779677(P05426) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-915744(P02454) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|agonist:Insulin was shown to increase or decrease GLUT4 protein interactions in specific cases.|comment:"Insulin decreased GLUT4 interactions with the following proteins: Q9ER30 (Sarcosin), P09527 (Rab-7), O88960 (N-ethylmaleimide sensitive), P09456 (PKA I regulatory subunit), P27881 (Hexokinase type II), P07872 (Acyl-coenzyme A oxidase), Q6DGF1 (Isocitrate dehydrogenase), Q9EQX9 (Ubiquitin-conjugating), Q63446 (Polyubiquitin), P24268 (Cathepsin D), Q91XW0 (Heat shock protein 86), Q5FVH0 (unknown), P58405 (Striatin 3), Q62667 (Major vault protein), Q66H50 (unknown), Q09167 (splicing factor), Q9JHU5 (Arfaptin 1)."|comment:"Insulin increased GLUT4 interaction with the following proteins:Q9Z1P2 (R-actinin-1), P45592 (Cofilin), Q9QXQ0 (R-actinin-4), P26473 (ADP-ribosylation factor), P26437 (ADP-ribosylation factor),   Q7TNP1 (Basigin 2), Q6P6R2 (Dihydrolipoamide dehydrogenase),   P04797 (GAPDH), Q63081 (Protein disulfide isomerase), P29457 (47 kDa heat shock protein), Q9R1J8 (Leprecan), O88638 (Putative eps protein),   Q64375 (Synaptonemal complex)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:NDPK - Interactions involving proteins containing InterPro domain IPR001564, Nucleoside diphosphate kinase, core.	taxid:10116(rat-l6)|taxid:10116(Rattus norvegicus)	-	2006/02/15	2021/11/30	rogid:PbFY2lfrty8yw40Jq7ShR7xfuV410116	rogid:vN1N65raHuqUWebaPPz7+EgNya010116	intact-crc:44F3A2176D02515F|rigid:9RVm0UBcqQF4k06RGKO89Bg16Q8	false	myc tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P19357	uniprotkb:P13596	intact:EBI-915426|uniprotkb:P97900|ensembl:ENSRNOP00000023256	intact:EBI-916499	psi-mi:glut4_rat(display_long)|uniprotkb:Glucose transporter type 4, insulin-responsive(gene name synonym)|uniprotkb:Slc2a4(gene name)|psi-mi:Slc2a4(display_short)|uniprotkb:Glut4(gene name synonym)	psi-mi:ncam1_rat(display_long)|uniprotkb:Ncam1(gene name)|psi-mi:Ncam1(display_short)|uniprotkb:Ncam(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Foster et al. (2006)	pubmed:16396496|mint:MINT-5218203	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-921030	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2711|refseq:NP_036883.1|refseq:XP_006246658.1|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007611"(learning or memory)|go:"GO:0007614"(short-term memory)|go:"GO:0007616"(long-term memory)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010021"(amylopectin biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031550"(positive regulation of brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044381"(glucose import in response to insulin stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046323"(glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0098694"(regulation of synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0098793"(presynapse)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002441("Glucose transporter, type 4 (GLUT4)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-189200|ensembl:ENSRNOG00000017226(gene)|ensembl:ENSRNOT00000023256(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)	rgd:67378|interpro:IPR003599(Immunoglobulin subtype)|go:"GO:0001928"(regulation of exocyst assembly)|go:"GO:0005104"(fibroblast growth factor receptor binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0007155"(cell adhesion)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007413"(axonal fasciculation)|go:"GO:0007420"(brain development)|go:"GO:0007568"(aging)|go:"GO:0007611"(learning or memory)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0008201"(heparin binding)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010035"(response to inorganic substance)|go:"GO:0010288"(response to lead ion)|go:"GO:0014012"(peripheral nervous system axon regeneration)|go:"GO:0014823"(response to activity)|go:"GO:0016338"(calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules)|go:"GO:0019902"(phosphatase binding)|go:"GO:0021794"(thalamus development)|go:"GO:0030275"(LRR domain binding)|go:"GO:0030424"(axon)|go:"GO:0030426"(growth cone)|go:"GO:0031100"(animal organ regeneration)|go:"GO:0031175"(neuron projection development)|go:"GO:0033555"(multicellular organismal response to stress)|go:"GO:0034109"(homotypic cell-cell adhesion)|go:"GO:0042220"(response to cocaine)|go:"GO:0042493"|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0048666"(neuron development)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0050850"(positive regulation of calcium-mediated signaling)|go:"GO:0051930"(regulation of sensory perception of pain)|go:"GO:0060045"(positive regulation of cardiac muscle cell proliferation)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0071219"(cellular response to molecule of bacterial origin)|go:"GO:0071241"(cellular response to inorganic substance)|go:"GO:0071679"(commissural neuron axon guidance)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099055"(integral component of postsynaptic membrane)|go:"GO:0099056"(integral component of presynaptic membrane)|go:"GO:2001260"(regulation of semaphorin-plexin signaling pathway)|rcsb pdb:1EPF|rcsb pdb:1LWR|rcsb pdb:1QZ1|reactome:R-RNO-375165|reactome:R-RNO-419037|reactome:R-RNO-445144|reactome:R-RNO-5673001|refseq:NP_113709.1|interpro:IPR003961(Fibronectin, type III)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR009138(Neural cell adhesion)|mint:P13596|interpro:IPR033019|interpro:IPR036116|interpro:IPR036179	-	-	-	caution:"The participant EBI-349571(P68370) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919386(Q7TP47) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920972(Q5XIP9) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-916419(P11980) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919578(Q8R491) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920554(Q5U3Z7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920647(Q5U2X8) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920585(Q7TP24) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-779677(P05426) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-915744(P02454) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|agonist:Insulin was shown to increase or decrease GLUT4 protein interactions in specific cases.|comment:"Insulin decreased GLUT4 interactions with the following proteins: Q9ER30 (Sarcosin), P09527 (Rab-7), O88960 (N-ethylmaleimide sensitive), P09456 (PKA I regulatory subunit), P27881 (Hexokinase type II), P07872 (Acyl-coenzyme A oxidase), Q6DGF1 (Isocitrate dehydrogenase), Q9EQX9 (Ubiquitin-conjugating), Q63446 (Polyubiquitin), P24268 (Cathepsin D), Q91XW0 (Heat shock protein 86), Q5FVH0 (unknown), P58405 (Striatin 3), Q62667 (Major vault protein), Q66H50 (unknown), Q09167 (splicing factor), Q9JHU5 (Arfaptin 1)."|comment:"Insulin increased GLUT4 interaction with the following proteins:Q9Z1P2 (R-actinin-1), P45592 (Cofilin), Q9QXQ0 (R-actinin-4), P26473 (ADP-ribosylation factor), P26437 (ADP-ribosylation factor),   Q7TNP1 (Basigin 2), Q6P6R2 (Dihydrolipoamide dehydrogenase),   P04797 (GAPDH), Q63081 (Protein disulfide isomerase), P29457 (47 kDa heat shock protein), Q9R1J8 (Leprecan), O88638 (Putative eps protein),   Q64375 (Synaptonemal complex)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:NDPK - Interactions involving proteins containing InterPro domain IPR001564, Nucleoside diphosphate kinase, core.	taxid:10116(rat-l6)|taxid:10116(Rattus norvegicus)	-	2006/02/15	2021/11/30	rogid:PbFY2lfrty8yw40Jq7ShR7xfuV410116	rogid:QM7RSMedN9uQfR5L0S/24RL15WM10116	intact-crc:44F3A2176D02515F|rigid:9RVm0UBcqQF4k06RGKO89Bg16Q8	false	myc tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P19357	uniprotkb:P13471	intact:EBI-915426|uniprotkb:P97900|ensembl:ENSRNOP00000023256	intact:EBI-916488	psi-mi:glut4_rat(display_long)|uniprotkb:Glucose transporter type 4, insulin-responsive(gene name synonym)|uniprotkb:Slc2a4(gene name)|psi-mi:Slc2a4(display_short)|uniprotkb:Glut4(gene name synonym)	psi-mi:rs14_rat(display_long)|uniprotkb:Rps14(gene name)|psi-mi:Rps14(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Foster et al. (2006)	pubmed:16396496|mint:MINT-5218203	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-921030	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2711|refseq:NP_036883.1|refseq:XP_006246658.1|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007611"(learning or memory)|go:"GO:0007614"(short-term memory)|go:"GO:0007616"(long-term memory)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010021"(amylopectin biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031550"(positive regulation of brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044381"(glucose import in response to insulin stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046323"(glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0098694"(regulation of synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0098793"(presynapse)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002441("Glucose transporter, type 4 (GLUT4)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-189200|ensembl:ENSRNOG00000017226(gene)|ensembl:ENSRNOT00000023256(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)	go:"GO:0005730"(nucleolus)|go:"GO:0006412"(translation)|go:"GO:0014069"(postsynaptic density)|go:"GO:0022626"(cytosolic ribosome)|go:"GO:0022627"(cytosolic small ribosomal subunit)|go:"GO:0030218"(erythrocyte differentiation)|go:"GO:0030490"(maturation of SSU-rRNA)|go:"GO:0045182"(translation regulator activity)|go:"GO:0048027"(mRNA 5'-UTR binding)|go:"GO:0070181"(small ribosomal subunit rRNA binding)|reactome:R-RNO-156827|reactome:R-RNO-1799339|reactome:R-RNO-6791226|reactome:R-RNO-72649|reactome:R-RNO-72689|reactome:R-RNO-72695|reactome:R-RNO-72702|reactome:R-RNO-72706|reactome:R-RNO-975956|reactome:R-RNO-975957|go:"GO:0000028"(ribosomal small subunit assembly)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000462"("maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)")|go:"GO:0003723"(RNA binding)|go:"GO:0003735"(structural constituent of ribosome)|rgd:62025|refseq:NP_073163.1|interpro:IPR001971(Ribosomal protein S11)|interpro:IPR018102|mint:P13471|interpro:IPR036967	-	-	-	caution:"The participant EBI-349571(P68370) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919386(Q7TP47) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920972(Q5XIP9) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-916419(P11980) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919578(Q8R491) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920554(Q5U3Z7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920647(Q5U2X8) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920585(Q7TP24) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-779677(P05426) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-915744(P02454) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|agonist:Insulin was shown to increase or decrease GLUT4 protein interactions in specific cases.|comment:"Insulin decreased GLUT4 interactions with the following proteins: Q9ER30 (Sarcosin), P09527 (Rab-7), O88960 (N-ethylmaleimide sensitive), P09456 (PKA I regulatory subunit), P27881 (Hexokinase type II), P07872 (Acyl-coenzyme A oxidase), Q6DGF1 (Isocitrate dehydrogenase), Q9EQX9 (Ubiquitin-conjugating), Q63446 (Polyubiquitin), P24268 (Cathepsin D), Q91XW0 (Heat shock protein 86), Q5FVH0 (unknown), P58405 (Striatin 3), Q62667 (Major vault protein), Q66H50 (unknown), Q09167 (splicing factor), Q9JHU5 (Arfaptin 1)."|comment:"Insulin increased GLUT4 interaction with the following proteins:Q9Z1P2 (R-actinin-1), P45592 (Cofilin), Q9QXQ0 (R-actinin-4), P26473 (ADP-ribosylation factor), P26437 (ADP-ribosylation factor),   Q7TNP1 (Basigin 2), Q6P6R2 (Dihydrolipoamide dehydrogenase),   P04797 (GAPDH), Q63081 (Protein disulfide isomerase), P29457 (47 kDa heat shock protein), Q9R1J8 (Leprecan), O88638 (Putative eps protein),   Q64375 (Synaptonemal complex)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:NDPK - Interactions involving proteins containing InterPro domain IPR001564, Nucleoside diphosphate kinase, core.	taxid:10116(rat-l6)|taxid:10116(Rattus norvegicus)	-	2006/02/15	2021/11/30	rogid:PbFY2lfrty8yw40Jq7ShR7xfuV410116	rogid:4EpJYQXfeVvuHu9n1bbcWzsbaL410116	intact-crc:44F3A2176D02515F|rigid:9RVm0UBcqQF4k06RGKO89Bg16Q8	false	myc tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P19357	uniprotkb:P13437	intact:EBI-915426|uniprotkb:P97900|ensembl:ENSRNOP00000023256	intact:EBI-916482	psi-mi:glut4_rat(display_long)|uniprotkb:Glucose transporter type 4, insulin-responsive(gene name synonym)|uniprotkb:Slc2a4(gene name)|psi-mi:Slc2a4(display_short)|uniprotkb:Glut4(gene name synonym)	psi-mi:thim_rat(display_long)|uniprotkb:Beta-ketothiolase(gene name synonym)|uniprotkb:Acetyl-CoA acyltransferase(gene name synonym)|uniprotkb:Mitochondrial 3-oxoacyl-CoA thiolase(gene name synonym)|uniprotkb:Acaa2(gene name)|psi-mi:Acaa2(display_short)|uniprotkb:Acetyl-CoA acetyltransferase(gene name synonym)|uniprotkb:Acyl-CoA hydrolase, mitochondrial(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Foster et al. (2006)	pubmed:16396496|mint:MINT-5218203	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-921030	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2711|refseq:NP_036883.1|refseq:XP_006246658.1|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007611"(learning or memory)|go:"GO:0007614"(short-term memory)|go:"GO:0007616"(long-term memory)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010021"(amylopectin biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031550"(positive regulation of brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044381"(glucose import in response to insulin stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046323"(glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0098694"(regulation of synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0098793"(presynapse)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002441("Glucose transporter, type 4 (GLUT4)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-189200|ensembl:ENSRNOG00000017226(gene)|ensembl:ENSRNOT00000023256(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)	go:"GO:0003985"(acetyl-CoA C-acetyltransferase activity)|go:"GO:0003986"(acetyl-CoA hydrolase activity)|go:"GO:0003988"(acetyl-CoA C-acyltransferase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0006084"(acetyl-CoA metabolic process)|go:"GO:0006635"(fatty acid beta-oxidation)|go:"GO:0016290"(palmitoyl-CoA hydrolase activity)|go:"GO:0047617"(acyl-CoA hydrolase activity)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0102991"(myristoyl-CoA hydrolase activity)|go:"GO:1901029"(negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway)|go:"GO:1902109"(negative regulation of mitochondrial membrane permeability involved in apoptotic process)|rgd:620482|refseq:NP_569117.1|interpro:IPR002155(Thiolase)|interpro:IPR016039(Thiolase-like)|interpro:IPR020615|interpro:IPR020610|interpro:IPR020617|interpro:IPR020613|interpro:IPR020616|reactome:R-RNO-77289	-	-	-	caution:"The participant EBI-349571(P68370) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919386(Q7TP47) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920972(Q5XIP9) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-916419(P11980) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919578(Q8R491) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920554(Q5U3Z7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920647(Q5U2X8) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920585(Q7TP24) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-779677(P05426) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-915744(P02454) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|agonist:Insulin was shown to increase or decrease GLUT4 protein interactions in specific cases.|comment:"Insulin decreased GLUT4 interactions with the following proteins: Q9ER30 (Sarcosin), P09527 (Rab-7), O88960 (N-ethylmaleimide sensitive), P09456 (PKA I regulatory subunit), P27881 (Hexokinase type II), P07872 (Acyl-coenzyme A oxidase), Q6DGF1 (Isocitrate dehydrogenase), Q9EQX9 (Ubiquitin-conjugating), Q63446 (Polyubiquitin), P24268 (Cathepsin D), Q91XW0 (Heat shock protein 86), Q5FVH0 (unknown), P58405 (Striatin 3), Q62667 (Major vault protein), Q66H50 (unknown), Q09167 (splicing factor), Q9JHU5 (Arfaptin 1)."|comment:"Insulin increased GLUT4 interaction with the following proteins:Q9Z1P2 (R-actinin-1), P45592 (Cofilin), Q9QXQ0 (R-actinin-4), P26473 (ADP-ribosylation factor), P26437 (ADP-ribosylation factor),   Q7TNP1 (Basigin 2), Q6P6R2 (Dihydrolipoamide dehydrogenase),   P04797 (GAPDH), Q63081 (Protein disulfide isomerase), P29457 (47 kDa heat shock protein), Q9R1J8 (Leprecan), O88638 (Putative eps protein),   Q64375 (Synaptonemal complex)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:NDPK - Interactions involving proteins containing InterPro domain IPR001564, Nucleoside diphosphate kinase, core.	taxid:10116(rat-l6)|taxid:10116(Rattus norvegicus)	-	2006/02/15	2021/11/30	rogid:PbFY2lfrty8yw40Jq7ShR7xfuV410116	rogid:oeGMCp4yZ2lI+JWKjehWUJ6VxO810116	intact-crc:44F3A2176D02515F|rigid:9RVm0UBcqQF4k06RGKO89Bg16Q8	false	myc tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P19357	uniprotkb:P13383	intact:EBI-915426|uniprotkb:P97900|ensembl:ENSRNOP00000023256	intact:EBI-916475	psi-mi:glut4_rat(display_long)|uniprotkb:Glucose transporter type 4, insulin-responsive(gene name synonym)|uniprotkb:Slc2a4(gene name)|psi-mi:Slc2a4(display_short)|uniprotkb:Glut4(gene name synonym)	psi-mi:nucl_rat(display_long)|uniprotkb:Protein C23(gene name synonym)|uniprotkb:Ncl(gene name)|psi-mi:Ncl(display_short)|uniprotkb:Nuc(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Foster et al. (2006)	pubmed:16396496|mint:MINT-5218203	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-921030	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2711|refseq:NP_036883.1|refseq:XP_006246658.1|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007611"(learning or memory)|go:"GO:0007614"(short-term memory)|go:"GO:0007616"(long-term memory)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010021"(amylopectin biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031550"(positive regulation of brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044381"(glucose import in response to insulin stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046323"(glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0098694"(regulation of synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0098793"(presynapse)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002441("Glucose transporter, type 4 (GLUT4)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-189200|ensembl:ENSRNOG00000017226(gene)|ensembl:ENSRNOT00000023256(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)	go:"GO:0001525"(angiogenesis)|go:"GO:0001650"(fibrillar center)|go:"GO:0001651"(dense fibrillar component)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005681"(spliceosomal complex)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005938"(cell cortex)|go:"GO:0006897"(endocytosis)|go:"GO:0007283"(spermatogenesis)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0009986"(cell surface)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0035368"(selenocysteine insertion sequence binding)|go:"GO:0042134"(rRNA primary transcript binding)|go:"GO:0042162"(telomeric DNA binding)|go:"GO:0042393"(histone binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043236"(laminin binding)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0044547"(DNA topoisomerase binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048026"(positive regulation of mRNA splicing, via spliceosome)|go:"GO:0048027"(mRNA 5'-UTR binding)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|go:"GO:0097421"(liver regeneration)|go:"GO:1901838"(positive regulation of transcription of nucleolar large rRNA by RNA polymerase I)|go:"GO:1990631"(ErbB-4 class receptor binding)|go:"GO:1990830"(cellular response to leukemia inhibitory factor)|go:"GO:1990904"(ribonucleoprotein complex)|go:"GO:2000232"(regulation of rRNA processing)|rgd:3153|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR034230|interpro:IPR034233|interpro:IPR034234|interpro:IPR034235|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR035979|reactome:R-RNO-6791226	-	-	-	caution:"The participant EBI-349571(P68370) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919386(Q7TP47) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920972(Q5XIP9) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-916419(P11980) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919578(Q8R491) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920554(Q5U3Z7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920647(Q5U2X8) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920585(Q7TP24) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-779677(P05426) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-915744(P02454) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|agonist:Insulin was shown to increase or decrease GLUT4 protein interactions in specific cases.|comment:"Insulin decreased GLUT4 interactions with the following proteins: Q9ER30 (Sarcosin), P09527 (Rab-7), O88960 (N-ethylmaleimide sensitive), P09456 (PKA I regulatory subunit), P27881 (Hexokinase type II), P07872 (Acyl-coenzyme A oxidase), Q6DGF1 (Isocitrate dehydrogenase), Q9EQX9 (Ubiquitin-conjugating), Q63446 (Polyubiquitin), P24268 (Cathepsin D), Q91XW0 (Heat shock protein 86), Q5FVH0 (unknown), P58405 (Striatin 3), Q62667 (Major vault protein), Q66H50 (unknown), Q09167 (splicing factor), Q9JHU5 (Arfaptin 1)."|comment:"Insulin increased GLUT4 interaction with the following proteins:Q9Z1P2 (R-actinin-1), P45592 (Cofilin), Q9QXQ0 (R-actinin-4), P26473 (ADP-ribosylation factor), P26437 (ADP-ribosylation factor),   Q7TNP1 (Basigin 2), Q6P6R2 (Dihydrolipoamide dehydrogenase),   P04797 (GAPDH), Q63081 (Protein disulfide isomerase), P29457 (47 kDa heat shock protein), Q9R1J8 (Leprecan), O88638 (Putative eps protein),   Q64375 (Synaptonemal complex)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:NDPK - Interactions involving proteins containing InterPro domain IPR001564, Nucleoside diphosphate kinase, core.	taxid:10116(rat-l6)|taxid:10116(Rattus norvegicus)	-	2006/02/15	2021/11/30	rogid:PbFY2lfrty8yw40Jq7ShR7xfuV410116	rogid:JVqgpMl61OVHro3SSF9sg0uIBfA10116	intact-crc:44F3A2176D02515F|rigid:9RVm0UBcqQF4k06RGKO89Bg16Q8	false	myc tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P19357	uniprotkb:P13086	intact:EBI-915426|uniprotkb:P97900|ensembl:ENSRNOP00000023256	intact:EBI-916468|uniprotkb:Q6P7S4	psi-mi:glut4_rat(display_long)|uniprotkb:Glucose transporter type 4, insulin-responsive(gene name synonym)|uniprotkb:Slc2a4(gene name)|psi-mi:Slc2a4(display_short)|uniprotkb:Glut4(gene name synonym)	psi-mi:suca_rat(display_long)|uniprotkb:Succinyl-CoA synthetase subunit alpha(gene name synonym)|uniprotkb:Suclg1(gene name)|psi-mi:Suclg1(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Foster et al. (2006)	pubmed:16396496|mint:MINT-5218203	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-921030	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2711|refseq:NP_036883.1|refseq:XP_006246658.1|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007611"(learning or memory)|go:"GO:0007614"(short-term memory)|go:"GO:0007616"(long-term memory)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010021"(amylopectin biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031550"(positive regulation of brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044381"(glucose import in response to insulin stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046323"(glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0098694"(regulation of synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0098793"(presynapse)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002441("Glucose transporter, type 4 (GLUT4)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-189200|ensembl:ENSRNOG00000017226(gene)|ensembl:ENSRNOT00000023256(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)	go:"GO:0004775"("succinate-CoA ligase (ADP-forming) activity")|go:"GO:0004776"("succinate-CoA ligase (GDP-forming) activity")|go:"GO:0005739"(mitochondrion)|go:"GO:0006099"(tricarboxylic acid cycle)|go:"GO:0006104"(succinyl-CoA metabolic process)|go:"GO:0006105"(succinate metabolic process)|go:"GO:0009361"("succinate-CoA ligase complex (ADP-forming)")|go:"GO:0019003"(GDP binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045244"("succinate-CoA ligase complex (GDP-forming)")|reactome:R-RNO-71403|mint:P13086|rgd:619821|refseq:NP_446204.2|interpro:IPR017440(ATP-citrate lyase/succinyl-CoA ligase, active site)|interpro:IPR003781(CoA-binding)|interpro:IPR005810(Succinyl-CoA ligase, alpha subunit)|interpro:IPR005811(ATP-citrate lyase/succinyl-CoA ligase)|interpro:IPR016102(Succinyl-CoA synthetase-like)|interpro:IPR033847|interpro:IPR036291	-	-	-	caution:"The participant EBI-349571(P68370) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919386(Q7TP47) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920972(Q5XIP9) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-916419(P11980) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919578(Q8R491) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920554(Q5U3Z7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920647(Q5U2X8) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920585(Q7TP24) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-779677(P05426) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-915744(P02454) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|agonist:Insulin was shown to increase or decrease GLUT4 protein interactions in specific cases.|comment:"Insulin decreased GLUT4 interactions with the following proteins: Q9ER30 (Sarcosin), P09527 (Rab-7), O88960 (N-ethylmaleimide sensitive), P09456 (PKA I regulatory subunit), P27881 (Hexokinase type II), P07872 (Acyl-coenzyme A oxidase), Q6DGF1 (Isocitrate dehydrogenase), Q9EQX9 (Ubiquitin-conjugating), Q63446 (Polyubiquitin), P24268 (Cathepsin D), Q91XW0 (Heat shock protein 86), Q5FVH0 (unknown), P58405 (Striatin 3), Q62667 (Major vault protein), Q66H50 (unknown), Q09167 (splicing factor), Q9JHU5 (Arfaptin 1)."|comment:"Insulin increased GLUT4 interaction with the following proteins:Q9Z1P2 (R-actinin-1), P45592 (Cofilin), Q9QXQ0 (R-actinin-4), P26473 (ADP-ribosylation factor), P26437 (ADP-ribosylation factor),   Q7TNP1 (Basigin 2), Q6P6R2 (Dihydrolipoamide dehydrogenase),   P04797 (GAPDH), Q63081 (Protein disulfide isomerase), P29457 (47 kDa heat shock protein), Q9R1J8 (Leprecan), O88638 (Putative eps protein),   Q64375 (Synaptonemal complex)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:NDPK - Interactions involving proteins containing InterPro domain IPR001564, Nucleoside diphosphate kinase, core.	taxid:10116(rat-l6)|taxid:10116(Rattus norvegicus)	-	2006/02/15	2021/11/30	rogid:PbFY2lfrty8yw40Jq7ShR7xfuV410116	rogid:DRQq0o+E21RHTJTPBltOD53IM2g10116	intact-crc:44F3A2176D02515F|rigid:9RVm0UBcqQF4k06RGKO89Bg16Q8	false	myc tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P19357	uniprotkb:P62902	intact:EBI-915426|uniprotkb:P97900|ensembl:ENSRNOP00000023256	intact:EBI-916450|uniprotkb:P12947|ensembl:ENSRNOP00000031078	psi-mi:glut4_rat(display_long)|uniprotkb:Glucose transporter type 4, insulin-responsive(gene name synonym)|uniprotkb:Slc2a4(gene name)|psi-mi:Slc2a4(display_short)|uniprotkb:Glut4(gene name synonym)	psi-mi:rl31_rat(display_long)|uniprotkb:Rpl31(gene name)|psi-mi:Rpl31(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Foster et al. (2006)	pubmed:16396496|mint:MINT-5218203	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-921030	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2711|refseq:NP_036883.1|refseq:XP_006246658.1|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007611"(learning or memory)|go:"GO:0007614"(short-term memory)|go:"GO:0007616"(long-term memory)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010021"(amylopectin biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031550"(positive regulation of brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044381"(glucose import in response to insulin stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046323"(glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0098694"(regulation of synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0098793"(presynapse)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002441("Glucose transporter, type 4 (GLUT4)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-189200|ensembl:ENSRNOG00000017226(gene)|ensembl:ENSRNOT00000023256(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)	ensembl:ENSRNOG00000013508(gene)|ensembl:ENSRNOT00000033733(transcript)|go:"GO:0002181"(cytoplasmic translation)|go:"GO:0003735"(structural constituent of ribosome)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0022625"(cytosolic large ribosomal subunit)|go:"GO:0022626"(cytosolic ribosome)|go:"GO:0042788"(polysomal ribosome)|go:"GO:0045202"(synapse)|interpro:IPR000054(Ribosomal protein L31e)|interpro:IPR020052|interpro:IPR023621|reactome:R-RNO-156827|reactome:R-RNO-1799339|reactome:R-RNO-6791226|reactome:R-RNO-72689|reactome:R-RNO-72706|reactome:R-RNO-975956|reactome:R-RNO-975957|rgd:621202|refseq:NP_071951.1	-	-	-	caution:"The participant EBI-349571(P68370) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919386(Q7TP47) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920972(Q5XIP9) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-916419(P11980) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919578(Q8R491) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920554(Q5U3Z7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920647(Q5U2X8) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920585(Q7TP24) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-779677(P05426) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-915744(P02454) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|agonist:Insulin was shown to increase or decrease GLUT4 protein interactions in specific cases.|comment:"Insulin decreased GLUT4 interactions with the following proteins: Q9ER30 (Sarcosin), P09527 (Rab-7), O88960 (N-ethylmaleimide sensitive), P09456 (PKA I regulatory subunit), P27881 (Hexokinase type II), P07872 (Acyl-coenzyme A oxidase), Q6DGF1 (Isocitrate dehydrogenase), Q9EQX9 (Ubiquitin-conjugating), Q63446 (Polyubiquitin), P24268 (Cathepsin D), Q91XW0 (Heat shock protein 86), Q5FVH0 (unknown), P58405 (Striatin 3), Q62667 (Major vault protein), Q66H50 (unknown), Q09167 (splicing factor), Q9JHU5 (Arfaptin 1)."|comment:"Insulin increased GLUT4 interaction with the following proteins:Q9Z1P2 (R-actinin-1), P45592 (Cofilin), Q9QXQ0 (R-actinin-4), P26473 (ADP-ribosylation factor), P26437 (ADP-ribosylation factor),   Q7TNP1 (Basigin 2), Q6P6R2 (Dihydrolipoamide dehydrogenase),   P04797 (GAPDH), Q63081 (Protein disulfide isomerase), P29457 (47 kDa heat shock protein), Q9R1J8 (Leprecan), O88638 (Putative eps protein),   Q64375 (Synaptonemal complex)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:NDPK - Interactions involving proteins containing InterPro domain IPR001564, Nucleoside diphosphate kinase, core.	taxid:10116(rat-l6)|taxid:10116(Rattus norvegicus)	-	2006/02/15	2021/11/30	rogid:PbFY2lfrty8yw40Jq7ShR7xfuV410116	rogid:77LFR7/2somk6blVogZf1XFdJLk10116	intact-crc:44F3A2176D02515F|rigid:9RVm0UBcqQF4k06RGKO89Bg16Q8	false	myc tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P19357	uniprotkb:P12749	intact:EBI-915426|uniprotkb:P97900|ensembl:ENSRNOP00000023256	intact:EBI-916441	psi-mi:glut4_rat(display_long)|uniprotkb:Glucose transporter type 4, insulin-responsive(gene name synonym)|uniprotkb:Slc2a4(gene name)|psi-mi:Slc2a4(display_short)|uniprotkb:Glut4(gene name synonym)	psi-mi:rl26_rat(display_long)|uniprotkb:Rpl26(gene name)|psi-mi:Rpl26(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Foster et al. (2006)	pubmed:16396496|mint:MINT-5218203	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-921030	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2711|refseq:NP_036883.1|refseq:XP_006246658.1|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007611"(learning or memory)|go:"GO:0007614"(short-term memory)|go:"GO:0007616"(long-term memory)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010021"(amylopectin biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031550"(positive regulation of brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044381"(glucose import in response to insulin stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046323"(glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0098694"(regulation of synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0098793"(presynapse)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002441("Glucose transporter, type 4 (GLUT4)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-189200|ensembl:ENSRNOG00000017226(gene)|ensembl:ENSRNOT00000023256(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)	interpro:IPR014722(Translation protein SH3-like, subgroup)|go:"GO:0002181"(cytoplasmic translation)|go:"GO:0003723"(RNA binding)|go:"GO:0003735"(structural constituent of ribosome)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006364"(rRNA processing)|go:"GO:0006977"(DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest)|go:"GO:0022625"(cytosolic large ribosomal subunit)|go:"GO:0022626"(cytosolic ribosome)|go:"GO:0034644"(cellular response to UV)|go:"GO:0042273"(ribosomal large subunit biogenesis)|go:"GO:0043195"(terminal bouton)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0048027"(mRNA 5'-UTR binding)|go:"GO:0071479"(cellular response to ionizing radiation)|go:"GO:0071480"(cellular response to gamma radiation)|go:"GO:1902164"(positive regulation of DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator)|go:"GO:1902167"(positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator)|go:"GO:1904803"(regulation of translation involved in cellular response to UV)|go:"GO:1990904"(ribonucleoprotein complex)|go:"GO:1990928"(response to amino acid starvation)|reactome:R-RNO-156827|reactome:R-RNO-1799339|reactome:R-RNO-6791226|reactome:R-RNO-72689|reactome:R-RNO-72706|reactome:R-RNO-975956|reactome:R-RNO-975957|rgd:1310607|interpro:IPR005824(KOW)|interpro:IPR005825(Ribosomal protein L24/L26, conserved site)|interpro:IPR005756(Ribosomal protein L26, eukaryotic/archaeal)|interpro:IPR008991(Translation protein SH3-like)|mint:P12749|interpro:IPR041988	-	-	-	caution:"The participant EBI-349571(P68370) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919386(Q7TP47) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920972(Q5XIP9) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-916419(P11980) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919578(Q8R491) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920554(Q5U3Z7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920647(Q5U2X8) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920585(Q7TP24) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-779677(P05426) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-915744(P02454) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|agonist:Insulin was shown to increase or decrease GLUT4 protein interactions in specific cases.|comment:"Insulin decreased GLUT4 interactions with the following proteins: Q9ER30 (Sarcosin), P09527 (Rab-7), O88960 (N-ethylmaleimide sensitive), P09456 (PKA I regulatory subunit), P27881 (Hexokinase type II), P07872 (Acyl-coenzyme A oxidase), Q6DGF1 (Isocitrate dehydrogenase), Q9EQX9 (Ubiquitin-conjugating), Q63446 (Polyubiquitin), P24268 (Cathepsin D), Q91XW0 (Heat shock protein 86), Q5FVH0 (unknown), P58405 (Striatin 3), Q62667 (Major vault protein), Q66H50 (unknown), Q09167 (splicing factor), Q9JHU5 (Arfaptin 1)."|comment:"Insulin increased GLUT4 interaction with the following proteins:Q9Z1P2 (R-actinin-1), P45592 (Cofilin), Q9QXQ0 (R-actinin-4), P26473 (ADP-ribosylation factor), P26437 (ADP-ribosylation factor),   Q7TNP1 (Basigin 2), Q6P6R2 (Dihydrolipoamide dehydrogenase),   P04797 (GAPDH), Q63081 (Protein disulfide isomerase), P29457 (47 kDa heat shock protein), Q9R1J8 (Leprecan), O88638 (Putative eps protein),   Q64375 (Synaptonemal complex)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:NDPK - Interactions involving proteins containing InterPro domain IPR001564, Nucleoside diphosphate kinase, core.	taxid:10116(rat-l6)|taxid:10116(Rattus norvegicus)	-	2006/02/15	2021/11/30	rogid:PbFY2lfrty8yw40Jq7ShR7xfuV410116	rogid:kfW/QgWzzbF7cdu+EpwHx81xMvs10116	intact-crc:44F3A2176D02515F|rigid:9RVm0UBcqQF4k06RGKO89Bg16Q8	false	myc tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P19357	uniprotkb:P12001	intact:EBI-915426|uniprotkb:P97900|ensembl:ENSRNOP00000023256	intact:EBI-916436	psi-mi:glut4_rat(display_long)|uniprotkb:Glucose transporter type 4, insulin-responsive(gene name synonym)|uniprotkb:Slc2a4(gene name)|psi-mi:Slc2a4(display_short)|uniprotkb:Glut4(gene name synonym)	psi-mi:rl18_rat(display_long)|uniprotkb:Rpl18(gene name)|psi-mi:Rpl18(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Foster et al. (2006)	pubmed:16396496|mint:MINT-5218203	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-921030	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2711|refseq:NP_036883.1|refseq:XP_006246658.1|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007611"(learning or memory)|go:"GO:0007614"(short-term memory)|go:"GO:0007616"(long-term memory)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010021"(amylopectin biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031550"(positive regulation of brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044381"(glucose import in response to insulin stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046323"(glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0098694"(regulation of synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0098793"(presynapse)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002441("Glucose transporter, type 4 (GLUT4)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-189200|ensembl:ENSRNOG00000017226(gene)|ensembl:ENSRNOT00000023256(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)	go:"GO:0002181"(cytoplasmic translation)|go:"GO:0003723"(RNA binding)|go:"GO:0003735"(structural constituent of ribosome)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0022625"(cytosolic large ribosomal subunit)|go:"GO:0022626"(cytosolic ribosome)|go:"GO:0042788"(polysomal ribosome)|go:"GO:0045202"(synapse)|go:"GO:0097421"(liver regeneration)|rgd:621182|refseq:NP_112364.1|interpro:IPR000039(Ribosomal protein L18e)|interpro:IPR021131|interpro:IPR021132|interpro:IPR036227|reactome:R-RNO-156827|reactome:R-RNO-1799339|reactome:R-RNO-6791226|reactome:R-RNO-72689|reactome:R-RNO-72706|reactome:R-RNO-975956|reactome:R-RNO-975957	-	-	-	caution:"The participant EBI-349571(P68370) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919386(Q7TP47) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920972(Q5XIP9) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-916419(P11980) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919578(Q8R491) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920554(Q5U3Z7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920647(Q5U2X8) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920585(Q7TP24) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-779677(P05426) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-915744(P02454) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|agonist:Insulin was shown to increase or decrease GLUT4 protein interactions in specific cases.|comment:"Insulin decreased GLUT4 interactions with the following proteins: Q9ER30 (Sarcosin), P09527 (Rab-7), O88960 (N-ethylmaleimide sensitive), P09456 (PKA I regulatory subunit), P27881 (Hexokinase type II), P07872 (Acyl-coenzyme A oxidase), Q6DGF1 (Isocitrate dehydrogenase), Q9EQX9 (Ubiquitin-conjugating), Q63446 (Polyubiquitin), P24268 (Cathepsin D), Q91XW0 (Heat shock protein 86), Q5FVH0 (unknown), P58405 (Striatin 3), Q62667 (Major vault protein), Q66H50 (unknown), Q09167 (splicing factor), Q9JHU5 (Arfaptin 1)."|comment:"Insulin increased GLUT4 interaction with the following proteins:Q9Z1P2 (R-actinin-1), P45592 (Cofilin), Q9QXQ0 (R-actinin-4), P26473 (ADP-ribosylation factor), P26437 (ADP-ribosylation factor),   Q7TNP1 (Basigin 2), Q6P6R2 (Dihydrolipoamide dehydrogenase),   P04797 (GAPDH), Q63081 (Protein disulfide isomerase), P29457 (47 kDa heat shock protein), Q9R1J8 (Leprecan), O88638 (Putative eps protein),   Q64375 (Synaptonemal complex)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:NDPK - Interactions involving proteins containing InterPro domain IPR001564, Nucleoside diphosphate kinase, core.	taxid:10116(rat-l6)|taxid:10116(Rattus norvegicus)	-	2006/02/15	2021/11/30	rogid:PbFY2lfrty8yw40Jq7ShR7xfuV410116	rogid:bcC+Ep/lHOXL747gMgt+U0pMxVc10116	intact-crc:44F3A2176D02515F|rigid:9RVm0UBcqQF4k06RGKO89Bg16Q8	false	myc tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P19357	uniprotkb:P11980	intact:EBI-915426|uniprotkb:P97900|ensembl:ENSRNOP00000023256	intact:EBI-916419|uniprotkb:P11981|ensembl:ENSRNOP00000015331	psi-mi:glut4_rat(display_long)|uniprotkb:Glucose transporter type 4, insulin-responsive(gene name synonym)|uniprotkb:Slc2a4(gene name)|psi-mi:Slc2a4(display_short)|uniprotkb:Glut4(gene name synonym)	psi-mi:kpym_rat(display_long)|uniprotkb:Pkm(gene name)|psi-mi:Pkm(display_short)|uniprotkb:Pkm2(gene name synonym)|uniprotkb:Pykm(gene name synonym)|uniprotkb:Pyruvate kinase muscle isozyme(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Foster et al. (2006)	pubmed:16396496|mint:MINT-5218203	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-921030	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2711|refseq:NP_036883.1|refseq:XP_006246658.1|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007611"(learning or memory)|go:"GO:0007614"(short-term memory)|go:"GO:0007616"(long-term memory)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010021"(amylopectin biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031550"(positive regulation of brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044381"(glucose import in response to insulin stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046323"(glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0098694"(regulation of synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0098793"(presynapse)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002441("Glucose transporter, type 4 (GLUT4)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-189200|ensembl:ENSRNOG00000017226(gene)|ensembl:ENSRNOT00000023256(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)	ensembl:ENSRNOG00000011329(gene)|ensembl:ENSRNOT00000015332(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001889"(liver development)|go:"GO:0003729"(mRNA binding)|go:"GO:0004743"(pyruvate kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0005929"(cilium)|go:"GO:0006006"(glucose metabolic process)|go:"GO:0006096"(glycolytic process)|go:"GO:0006754"(ATP biosynthetic process)|go:"GO:0007584"(response to nutrient)|go:"GO:0009629"(response to gravity)|go:"GO:0010033"(response to organic substance)|go:"GO:0012501"(programmed cell death)|go:"GO:0014870"(response to muscle inactivity)|go:"GO:0016301"(kinase activity)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031100"(animal organ regeneration)|go:"GO:0032868"(response to insulin)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042802"(identical protein binding)|go:"GO:0042866"(pyruvate biosynthetic process)|go:"GO:0043403"(skeletal muscle tissue regeneration)|go:"GO:0043531"(ADP binding)|go:"GO:0070324"(thyroid hormone binding)|go:"GO:1902912"(pyruvate kinase complex)|go:"GO:1903672"(positive regulation of sprouting angiogenesis)|go:"GO:2000767"(positive regulation of cytoplasmic translation)|interpro:IPR001697(Pyruvate kinase)|interpro:IPR011037(Pyruvate kinase, beta-barrel-like)|interpro:IPR015793(Pyruvate kinase, barrel)|interpro:IPR015795(Pyruvate kinase, C-terminal-like)|interpro:IPR015806(Pyruvate kinase, beta-barrel)|interpro:IPR015813(Pyruvate/Phosphoenolpyruvate kinase, catalytic core)|interpro:IPR018209|interpro:IPR036918|interpro:IPR040442|mint:P11980|refseq:XP_006243250.2|rgd:3337|refseq:NP_445749.1	-	-	-	caution:"The participant EBI-349571(P68370) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919386(Q7TP47) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920972(Q5XIP9) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-916419(P11980) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919578(Q8R491) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920554(Q5U3Z7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920647(Q5U2X8) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920585(Q7TP24) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-779677(P05426) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-915744(P02454) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|agonist:Insulin was shown to increase or decrease GLUT4 protein interactions in specific cases.|comment:"Insulin decreased GLUT4 interactions with the following proteins: Q9ER30 (Sarcosin), P09527 (Rab-7), O88960 (N-ethylmaleimide sensitive), P09456 (PKA I regulatory subunit), P27881 (Hexokinase type II), P07872 (Acyl-coenzyme A oxidase), Q6DGF1 (Isocitrate dehydrogenase), Q9EQX9 (Ubiquitin-conjugating), Q63446 (Polyubiquitin), P24268 (Cathepsin D), Q91XW0 (Heat shock protein 86), Q5FVH0 (unknown), P58405 (Striatin 3), Q62667 (Major vault protein), Q66H50 (unknown), Q09167 (splicing factor), Q9JHU5 (Arfaptin 1)."|comment:"Insulin increased GLUT4 interaction with the following proteins:Q9Z1P2 (R-actinin-1), P45592 (Cofilin), Q9QXQ0 (R-actinin-4), P26473 (ADP-ribosylation factor), P26437 (ADP-ribosylation factor),   Q7TNP1 (Basigin 2), Q6P6R2 (Dihydrolipoamide dehydrogenase),   P04797 (GAPDH), Q63081 (Protein disulfide isomerase), P29457 (47 kDa heat shock protein), Q9R1J8 (Leprecan), O88638 (Putative eps protein),   Q64375 (Synaptonemal complex)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:NDPK - Interactions involving proteins containing InterPro domain IPR001564, Nucleoside diphosphate kinase, core.	taxid:10116(rat-l6)|taxid:10116(Rattus norvegicus)	-	2006/02/15	2021/11/30	rogid:PbFY2lfrty8yw40Jq7ShR7xfuV410116	rogid:GYxco5bbxaUXWMal0+5tWXFouDc10116	intact-crc:44F3A2176D02515F|rigid:9RVm0UBcqQF4k06RGKO89Bg16Q8	false	myc tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P19357	uniprotkb:P11960	intact:EBI-915426|uniprotkb:P97900|ensembl:ENSRNOP00000023256	intact:EBI-916408	psi-mi:glut4_rat(display_long)|uniprotkb:Glucose transporter type 4, insulin-responsive(gene name synonym)|uniprotkb:Slc2a4(gene name)|psi-mi:Slc2a4(display_short)|uniprotkb:Glut4(gene name synonym)	psi-mi:odba_rat(display_long)|uniprotkb:Branched-chain alpha-keto acid dehydrogenase E1 component alpha chain(gene name synonym)|uniprotkb:Bckdha(gene name)|psi-mi:Bckdha(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Foster et al. (2006)	pubmed:16396496|mint:MINT-5218203	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-921030	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2711|refseq:NP_036883.1|refseq:XP_006246658.1|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007611"(learning or memory)|go:"GO:0007614"(short-term memory)|go:"GO:0007616"(long-term memory)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010021"(amylopectin biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031550"(positive regulation of brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044381"(glucose import in response to insulin stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046323"(glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0098694"(regulation of synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0098793"(presynapse)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002441("Glucose transporter, type 4 (GLUT4)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-189200|ensembl:ENSRNOG00000017226(gene)|ensembl:ENSRNOT00000023256(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)	interpro:IPR034616|go:"GO:0009083"(branched-chain amino acid catabolic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0047101"("2-oxoisovalerate dehydrogenase (acylating) activity")|go:"GO:0051384"(response to glucocorticoid)|go:"GO:0003863"("3-methyl-2-oxobutanoate dehydrogenase (2-methylpropanoyl-transferring) activity")|go:"GO:0005739"(mitochondrion)|go:"GO:0005947"(mitochondrial alpha-ketoglutarate dehydrogenase complex)|go:"GO:0007584"(response to nutrient)|go:"GO:0051591"(response to cAMP)|reactome:R-RNO-389661|reactome:R-RNO-70895|mint:P11960|rgd:2196|refseq:NP_036914.1|interpro:IPR001017(Dehydrogenase, E1 component)|interpro:IPR029061	-	-	-	caution:"The participant EBI-349571(P68370) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919386(Q7TP47) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920972(Q5XIP9) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-916419(P11980) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919578(Q8R491) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920554(Q5U3Z7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920647(Q5U2X8) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920585(Q7TP24) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-779677(P05426) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-915744(P02454) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|agonist:Insulin was shown to increase or decrease GLUT4 protein interactions in specific cases.|comment:"Insulin decreased GLUT4 interactions with the following proteins: Q9ER30 (Sarcosin), P09527 (Rab-7), O88960 (N-ethylmaleimide sensitive), P09456 (PKA I regulatory subunit), P27881 (Hexokinase type II), P07872 (Acyl-coenzyme A oxidase), Q6DGF1 (Isocitrate dehydrogenase), Q9EQX9 (Ubiquitin-conjugating), Q63446 (Polyubiquitin), P24268 (Cathepsin D), Q91XW0 (Heat shock protein 86), Q5FVH0 (unknown), P58405 (Striatin 3), Q62667 (Major vault protein), Q66H50 (unknown), Q09167 (splicing factor), Q9JHU5 (Arfaptin 1)."|comment:"Insulin increased GLUT4 interaction with the following proteins:Q9Z1P2 (R-actinin-1), P45592 (Cofilin), Q9QXQ0 (R-actinin-4), P26473 (ADP-ribosylation factor), P26437 (ADP-ribosylation factor),   Q7TNP1 (Basigin 2), Q6P6R2 (Dihydrolipoamide dehydrogenase),   P04797 (GAPDH), Q63081 (Protein disulfide isomerase), P29457 (47 kDa heat shock protein), Q9R1J8 (Leprecan), O88638 (Putative eps protein),   Q64375 (Synaptonemal complex)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:NDPK - Interactions involving proteins containing InterPro domain IPR001564, Nucleoside diphosphate kinase, core.	taxid:10116(rat-l6)|taxid:10116(Rattus norvegicus)	-	2006/02/15	2021/11/30	rogid:PbFY2lfrty8yw40Jq7ShR7xfuV410116	rogid:XAi/0rSMFYOnlY8SZrOBbpSsI9Q10116	intact-crc:44F3A2176D02515F|rigid:9RVm0UBcqQF4k06RGKO89Bg16Q8	false	myc tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P19357	uniprotkb:P11884	intact:EBI-915426|uniprotkb:P97900|ensembl:ENSRNOP00000023256	intact:EBI-916402|uniprotkb:Q6Q288|uniprotkb:Q6Q289|uniprotkb:Q6Q290|uniprotkb:Q8K3V8|uniprotkb:Q91ZD7	psi-mi:glut4_rat(display_long)|uniprotkb:Glucose transporter type 4, insulin-responsive(gene name synonym)|uniprotkb:Slc2a4(gene name)|psi-mi:Slc2a4(display_short)|uniprotkb:Glut4(gene name synonym)	psi-mi:aldh2_rat(display_long)|uniprotkb:ALDH class 2(gene name synonym)|uniprotkb:ALDH1(gene name synonym)|uniprotkb:ALDH-E2(gene name synonym)|uniprotkb:Aldh2(gene name)|psi-mi:Aldh2(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Foster et al. (2006)	pubmed:16396496|mint:MINT-5218203	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-921030	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2711|refseq:NP_036883.1|refseq:XP_006246658.1|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007611"(learning or memory)|go:"GO:0007614"(short-term memory)|go:"GO:0007616"(long-term memory)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010021"(amylopectin biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031550"(positive regulation of brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044381"(glucose import in response to insulin stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046323"(glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0098694"(regulation of synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0098793"(presynapse)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002441("Glucose transporter, type 4 (GLUT4)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-189200|ensembl:ENSRNOG00000017226(gene)|ensembl:ENSRNOT00000023256(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)	go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032570"(response to progesterone)|go:"GO:0032870"(cellular response to hormone stimulus)|go:"GO:0033574"(response to testosterone)|go:"GO:0035094"(response to nicotine)|go:"GO:0042802"(identical protein binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043878"("glyceraldehyde-3-phosphate dehydrogenase (NAD+) (non-phosphorylating) activity")|go:"GO:0045471"(response to ethanol)|go:"GO:0048149"(behavioral response to ethanol)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0055093"(response to hyperoxia)|go:"GO:0070404"(NADH binding)|go:"GO:0071398"(cellular response to fatty acid)|go:"GO:0110095"(cellular detoxification of aldehyde)|go:"GO:1902882"(regulation of response to oxidative stress)|go:"GO:1904639"(cellular response to resveratrol)|go:"GO:2000377"(regulation of reactive oxygen species metabolic process)|go:"GO:0001889"(liver development)|go:"GO:0002931"(response to ischemia)|go:"GO:0004029"("aldehyde dehydrogenase (NAD+) activity")|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0006067"(ethanol metabolic process)|go:"GO:0006068"(ethanol catabolic process)|go:"GO:0006117"(acetaldehyde metabolic process)|go:"GO:0008631"(intrinsic apoptotic signaling pathway in response to oxidative stress)|go:"GO:0008637"(apoptotic mitochondrial changes)|go:"GO:0009408"(response to heat)|go:"GO:0014070"(response to organic cyclic compound)|go:"GO:0032355"(response to estradiol)|rcsb pdb:5AZ8|rgd:69219|refseq:NP_115792.1|interpro:IPR016161(Aldehyde/histidinol dehydrogenase)|interpro:IPR016160(Aldehyde dehydrogenase, conserved site)|interpro:IPR016162(Aldehyde dehydrogenase, N-terminal)|interpro:IPR015590(Aldehyde dehydrogenase)|rcsb pdb:1OM2|rcsb pdb:2V1S|rcsb pdb:2V1T|rcsb pdb:3AWR|rcsb pdb:3AX2|rcsb pdb:3AX3|rcsb pdb:3AX5|interpro:IPR029510|interpro:IPR016163(Aldehyde dehydrogenase, C-terminal)|reactome:R-RNO-71384|reactome:R-RNO-380612	-	-	-	caution:"The participant EBI-349571(P68370) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919386(Q7TP47) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920972(Q5XIP9) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-916419(P11980) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919578(Q8R491) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920554(Q5U3Z7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920647(Q5U2X8) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920585(Q7TP24) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-779677(P05426) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-915744(P02454) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|agonist:Insulin was shown to increase or decrease GLUT4 protein interactions in specific cases.|comment:"Insulin decreased GLUT4 interactions with the following proteins: Q9ER30 (Sarcosin), P09527 (Rab-7), O88960 (N-ethylmaleimide sensitive), P09456 (PKA I regulatory subunit), P27881 (Hexokinase type II), P07872 (Acyl-coenzyme A oxidase), Q6DGF1 (Isocitrate dehydrogenase), Q9EQX9 (Ubiquitin-conjugating), Q63446 (Polyubiquitin), P24268 (Cathepsin D), Q91XW0 (Heat shock protein 86), Q5FVH0 (unknown), P58405 (Striatin 3), Q62667 (Major vault protein), Q66H50 (unknown), Q09167 (splicing factor), Q9JHU5 (Arfaptin 1)."|comment:"Insulin increased GLUT4 interaction with the following proteins:Q9Z1P2 (R-actinin-1), P45592 (Cofilin), Q9QXQ0 (R-actinin-4), P26473 (ADP-ribosylation factor), P26437 (ADP-ribosylation factor),   Q7TNP1 (Basigin 2), Q6P6R2 (Dihydrolipoamide dehydrogenase),   P04797 (GAPDH), Q63081 (Protein disulfide isomerase), P29457 (47 kDa heat shock protein), Q9R1J8 (Leprecan), O88638 (Putative eps protein),   Q64375 (Synaptonemal complex)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:NDPK - Interactions involving proteins containing InterPro domain IPR001564, Nucleoside diphosphate kinase, core.	taxid:10116(rat-l6)|taxid:10116(Rattus norvegicus)	-	2006/02/15	2021/11/30	rogid:PbFY2lfrty8yw40Jq7ShR7xfuV410116	rogid:ky5VO6/2tobrmxxftl2k8kWifkA10116	intact-crc:44F3A2176D02515F|rigid:9RVm0UBcqQF4k06RGKO89Bg16Q8	false	myc tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P19357	uniprotkb:P11883	intact:EBI-915426|uniprotkb:P97900|ensembl:ENSRNOP00000023256	intact:EBI-916393|ensembl:ENSRNOP00000003182	psi-mi:glut4_rat(display_long)|uniprotkb:Glucose transporter type 4, insulin-responsive(gene name synonym)|uniprotkb:Slc2a4(gene name)|psi-mi:Slc2a4(display_short)|uniprotkb:Glut4(gene name synonym)	psi-mi:al3a1_rat(display_long)|uniprotkb:Aldehyde dehydrogenase family 3 member A1(gene name synonym)|uniprotkb:Tumor-associated aldehyde dehydrogenase(gene name synonym)|uniprotkb:HTC-ALDH(gene name synonym)|uniprotkb:Aldh3a1(gene name)|psi-mi:Aldh3a1(display_short)|uniprotkb:Aldd(gene name synonym)|uniprotkb:Aldh3(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Foster et al. (2006)	pubmed:16396496|mint:MINT-5218203	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-921030	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2711|refseq:NP_036883.1|refseq:XP_006246658.1|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007611"(learning or memory)|go:"GO:0007614"(short-term memory)|go:"GO:0007616"(long-term memory)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010021"(amylopectin biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031550"(positive regulation of brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044381"(glucose import in response to insulin stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046323"(glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0098694"(regulation of synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0098793"(presynapse)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002441("Glucose transporter, type 4 (GLUT4)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-189200|ensembl:ENSRNOG00000017226(gene)|ensembl:ENSRNOT00000023256(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)	rgd:2088|refseq:NP_114178.1|ensembl:ENSRNOG00000002331(gene)|ensembl:ENSRNOT00000003182(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0004028"(3-chloroallyl aldehyde dehydrogenase activity)|go:"GO:0004029"("aldehyde dehydrogenase (NAD+) activity")|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006081"(cellular aldehyde metabolic process)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008106"("alcohol dehydrogenase (NADP+) activity")|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0014070"(response to organic cyclic compound)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016620"(oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor)|go:"GO:0018479"("benzaldehyde dehydrogenase (NAD+) activity")|go:"GO:0042493"|go:"GO:0051384"(response to glucocorticoid)|go:"GO:0051591"(response to cAMP)|interpro:IPR012394("Aldehyde dehydrogenase NAD(P)-dependent")|interpro:IPR015590(Aldehyde dehydrogenase)|interpro:IPR016160(Aldehyde dehydrogenase, conserved site)|interpro:IPR016161(Aldehyde/histidinol dehydrogenase)|interpro:IPR016162(Aldehyde dehydrogenase, N-terminal)|interpro:IPR016163(Aldehyde dehydrogenase, C-terminal)|interpro:IPR029510|rcsb pdb:1AD3|reactome:R-RNO-211945	-	-	-	caution:"The participant EBI-349571(P68370) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919386(Q7TP47) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920972(Q5XIP9) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-916419(P11980) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919578(Q8R491) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920554(Q5U3Z7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920647(Q5U2X8) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920585(Q7TP24) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-779677(P05426) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-915744(P02454) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|agonist:Insulin was shown to increase or decrease GLUT4 protein interactions in specific cases.|comment:"Insulin decreased GLUT4 interactions with the following proteins: Q9ER30 (Sarcosin), P09527 (Rab-7), O88960 (N-ethylmaleimide sensitive), P09456 (PKA I regulatory subunit), P27881 (Hexokinase type II), P07872 (Acyl-coenzyme A oxidase), Q6DGF1 (Isocitrate dehydrogenase), Q9EQX9 (Ubiquitin-conjugating), Q63446 (Polyubiquitin), P24268 (Cathepsin D), Q91XW0 (Heat shock protein 86), Q5FVH0 (unknown), P58405 (Striatin 3), Q62667 (Major vault protein), Q66H50 (unknown), Q09167 (splicing factor), Q9JHU5 (Arfaptin 1)."|comment:"Insulin increased GLUT4 interaction with the following proteins:Q9Z1P2 (R-actinin-1), P45592 (Cofilin), Q9QXQ0 (R-actinin-4), P26473 (ADP-ribosylation factor), P26437 (ADP-ribosylation factor),   Q7TNP1 (Basigin 2), Q6P6R2 (Dihydrolipoamide dehydrogenase),   P04797 (GAPDH), Q63081 (Protein disulfide isomerase), P29457 (47 kDa heat shock protein), Q9R1J8 (Leprecan), O88638 (Putative eps protein),   Q64375 (Synaptonemal complex)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:NDPK - Interactions involving proteins containing InterPro domain IPR001564, Nucleoside diphosphate kinase, core.	taxid:10116(rat-l6)|taxid:10116(Rattus norvegicus)	-	2006/02/15	2021/11/30	rogid:PbFY2lfrty8yw40Jq7ShR7xfuV410116	rogid:5bGQBYOjXu8q7xbc2dpgQRm4VrE10116	intact-crc:44F3A2176D02515F|rigid:9RVm0UBcqQF4k06RGKO89Bg16Q8	false	myc tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P19357	uniprotkb:P11762	intact:EBI-915426|uniprotkb:P97900|ensembl:ENSRNOP00000023256	intact:EBI-916386|ensembl:ENSRNOP00000013538	psi-mi:glut4_rat(display_long)|uniprotkb:Glucose transporter type 4, insulin-responsive(gene name synonym)|uniprotkb:Slc2a4(gene name)|psi-mi:Slc2a4(display_short)|uniprotkb:Glut4(gene name synonym)	psi-mi:leg1_rat(display_long)|uniprotkb:Lectin galactoside-binding soluble 1(gene name synonym)|uniprotkb:Beta-galactoside-binding lectin L-14-I(gene name synonym)|uniprotkb:S-Lac lectin 1(gene name synonym)|uniprotkb:Galaptin(gene name synonym)|uniprotkb:14 kDa lectin(gene name synonym)|uniprotkb:RL 14.5(gene name synonym)|uniprotkb:Lgals1(gene name)|psi-mi:Lgals1(display_short)|uniprotkb:Lactose-binding lectin 1(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Foster et al. (2006)	pubmed:16396496|mint:MINT-5218203	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-921030	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2711|refseq:NP_036883.1|refseq:XP_006246658.1|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007611"(learning or memory)|go:"GO:0007614"(short-term memory)|go:"GO:0007616"(long-term memory)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010021"(amylopectin biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031550"(positive regulation of brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044381"(glucose import in response to insulin stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046323"(glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0098694"(regulation of synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0098793"(presynapse)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002441("Glucose transporter, type 4 (GLUT4)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-189200|ensembl:ENSRNOG00000017226(gene)|ensembl:ENSRNOT00000023256(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)	rgd:69355|refseq:NP_063969.1|go:"GO:0034120"(positive regulation of erythrocyte aggregation)|go:"GO:0035900"(response to isolation stress)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0043236"(laminin binding)|go:"GO:0045445"(myoblast differentiation)|go:"GO:0046598"(positive regulation of viral entry into host cell)|go:"GO:0048678"(response to axon injury)|go:"GO:0071333"(cellular response to glucose stimulus)|go:"GO:0071407"(cellular response to organic cyclic compound)|interpro:IPR001079(Galectin, galactose-binding lectin)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR044156|rcsb pdb:3M2M|rcsb pdb:4GA9|rcsb pdb:4NO4|reactome:R-RNO-381426|reactome:R-RNO-8957275|ensembl:ENSRNOG00000009884(gene)|ensembl:ENSRNOT00000013538(transcript)|go:"GO:0002317"(plasma cell differentiation)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0009986"(cell surface)|go:"GO:0010812"(negative regulation of cell-substrate adhesion)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0030246"(carbohydrate binding)|go:"GO:0030395"(lactose binding)|go:"GO:0031295"(T cell costimulation)|dip:DIP-37188N	-	-	-	caution:"The participant EBI-349571(P68370) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919386(Q7TP47) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920972(Q5XIP9) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-916419(P11980) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919578(Q8R491) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920554(Q5U3Z7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920647(Q5U2X8) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920585(Q7TP24) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-779677(P05426) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-915744(P02454) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|agonist:Insulin was shown to increase or decrease GLUT4 protein interactions in specific cases.|comment:"Insulin decreased GLUT4 interactions with the following proteins: Q9ER30 (Sarcosin), P09527 (Rab-7), O88960 (N-ethylmaleimide sensitive), P09456 (PKA I regulatory subunit), P27881 (Hexokinase type II), P07872 (Acyl-coenzyme A oxidase), Q6DGF1 (Isocitrate dehydrogenase), Q9EQX9 (Ubiquitin-conjugating), Q63446 (Polyubiquitin), P24268 (Cathepsin D), Q91XW0 (Heat shock protein 86), Q5FVH0 (unknown), P58405 (Striatin 3), Q62667 (Major vault protein), Q66H50 (unknown), Q09167 (splicing factor), Q9JHU5 (Arfaptin 1)."|comment:"Insulin increased GLUT4 interaction with the following proteins:Q9Z1P2 (R-actinin-1), P45592 (Cofilin), Q9QXQ0 (R-actinin-4), P26473 (ADP-ribosylation factor), P26437 (ADP-ribosylation factor),   Q7TNP1 (Basigin 2), Q6P6R2 (Dihydrolipoamide dehydrogenase),   P04797 (GAPDH), Q63081 (Protein disulfide isomerase), P29457 (47 kDa heat shock protein), Q9R1J8 (Leprecan), O88638 (Putative eps protein),   Q64375 (Synaptonemal complex)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:NDPK - Interactions involving proteins containing InterPro domain IPR001564, Nucleoside diphosphate kinase, core.	taxid:10116(rat-l6)|taxid:10116(Rattus norvegicus)	-	2006/02/15	2021/11/30	rogid:PbFY2lfrty8yw40Jq7ShR7xfuV410116	rogid:Dbi5RtFojXDfto2il4HjjUTpfHI10116	intact-crc:44F3A2176D02515F|rigid:9RVm0UBcqQF4k06RGKO89Bg16Q8	false	myc tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P19357	uniprotkb:P11730	intact:EBI-915426|uniprotkb:P97900|ensembl:ENSRNOP00000023256	intact:EBI-916359|uniprotkb:Q64003|uniprotkb:Q64004|ensembl:ENSRNOP00000062321	psi-mi:glut4_rat(display_long)|uniprotkb:Glucose transporter type 4, insulin-responsive(gene name synonym)|uniprotkb:Slc2a4(gene name)|psi-mi:Slc2a4(display_short)|uniprotkb:Glut4(gene name synonym)	psi-mi:kcc2g_rat(display_long)|uniprotkb:Camk2g(gene name)|psi-mi:Camk2g(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Foster et al. (2006)	pubmed:16396496|mint:MINT-5218203	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-921030	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2711|refseq:NP_036883.1|refseq:XP_006246658.1|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007611"(learning or memory)|go:"GO:0007614"(short-term memory)|go:"GO:0007616"(long-term memory)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010021"(amylopectin biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031550"(positive regulation of brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044381"(glucose import in response to insulin stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046323"(glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0098694"(regulation of synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0098793"(presynapse)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002441("Glucose transporter, type 4 (GLUT4)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-189200|ensembl:ENSRNOG00000017226(gene)|ensembl:ENSRNOT00000023256(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)	rgd:621802|refseq:NP_598289.1|ensembl:ENSRNOG00000009783(gene)|ensembl:ENSRNOT00000066163(transcript)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0001666"(response to hypoxia)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004683"(calmodulin-dependent protein kinase activity)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005954"(calcium- and calmodulin-dependent protein kinase complex)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0007399"(nervous system development)|go:"GO:0010975"(regulation of neuron projection development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0030154"(cell differentiation)|go:"GO:0033017"(sarcoplasmic reticulum membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043005"(neuron projection)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1901897"(regulation of relaxation of cardiac muscle)|go:"GO:1903076"(regulation of protein localization to plasma membrane)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR013543(Calcium/calmodulin dependent protein kinase II, association-domain)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR032710|mint:P11730|reactome:R-RNO-3371571|reactome:R-RNO-399719|reactome:R-RNO-438066|reactome:R-RNO-5576892|reactome:R-RNO-5578775|reactome:R-RNO-5673000|reactome:R-RNO-5673001|reactome:R-RNO-877300|reactome:R-RNO-936837|refseq:XP_008768721.1	-	-	-	caution:"The participant EBI-349571(P68370) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919386(Q7TP47) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920972(Q5XIP9) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-916419(P11980) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919578(Q8R491) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920554(Q5U3Z7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920647(Q5U2X8) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920585(Q7TP24) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-779677(P05426) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-915744(P02454) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|agonist:Insulin was shown to increase or decrease GLUT4 protein interactions in specific cases.|comment:"Insulin decreased GLUT4 interactions with the following proteins: Q9ER30 (Sarcosin), P09527 (Rab-7), O88960 (N-ethylmaleimide sensitive), P09456 (PKA I regulatory subunit), P27881 (Hexokinase type II), P07872 (Acyl-coenzyme A oxidase), Q6DGF1 (Isocitrate dehydrogenase), Q9EQX9 (Ubiquitin-conjugating), Q63446 (Polyubiquitin), P24268 (Cathepsin D), Q91XW0 (Heat shock protein 86), Q5FVH0 (unknown), P58405 (Striatin 3), Q62667 (Major vault protein), Q66H50 (unknown), Q09167 (splicing factor), Q9JHU5 (Arfaptin 1)."|comment:"Insulin increased GLUT4 interaction with the following proteins:Q9Z1P2 (R-actinin-1), P45592 (Cofilin), Q9QXQ0 (R-actinin-4), P26473 (ADP-ribosylation factor), P26437 (ADP-ribosylation factor),   Q7TNP1 (Basigin 2), Q6P6R2 (Dihydrolipoamide dehydrogenase),   P04797 (GAPDH), Q63081 (Protein disulfide isomerase), P29457 (47 kDa heat shock protein), Q9R1J8 (Leprecan), O88638 (Putative eps protein),   Q64375 (Synaptonemal complex)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:NDPK - Interactions involving proteins containing InterPro domain IPR001564, Nucleoside diphosphate kinase, core.	taxid:10116(rat-l6)|taxid:10116(Rattus norvegicus)	-	2006/02/15	2021/11/30	rogid:PbFY2lfrty8yw40Jq7ShR7xfuV410116	rogid:HFnqkrMFXXpL90nLx86YWIJ8z/810116	intact-crc:44F3A2176D02515F|rigid:9RVm0UBcqQF4k06RGKO89Bg16Q8	false	myc tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P19357	uniprotkb:Q9QZK5	intact:EBI-915426|uniprotkb:P97900|ensembl:ENSRNOP00000023256	intact:EBI-920080|ensembl:ENSRNOP00000027860	psi-mi:glut4_rat(display_long)|uniprotkb:Glucose transporter type 4, insulin-responsive(gene name synonym)|uniprotkb:Slc2a4(gene name)|psi-mi:Slc2a4(display_short)|uniprotkb:Glut4(gene name synonym)	psi-mi:htra1_rat(display_long)|uniprotkb:Htra1(gene name)|psi-mi:Htra1(display_short)|uniprotkb:Prss11(gene name synonym)|uniprotkb:High-temperature requirement A serine peptidase 1(gene name synonym)|uniprotkb:Htra(gene name synonym)|uniprotkb:Serine protease 11(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Foster et al. (2006)	pubmed:16396496|mint:MINT-5218203	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-921030	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2711|refseq:NP_036883.1|refseq:XP_006246658.1|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007611"(learning or memory)|go:"GO:0007614"(short-term memory)|go:"GO:0007616"(long-term memory)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010021"(amylopectin biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031550"(positive regulation of brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044381"(glucose import in response to insulin stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046323"(glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0098694"(regulation of synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0098793"(presynapse)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002441("Glucose transporter, type 4 (GLUT4)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-189200|ensembl:ENSRNOG00000017226(gene)|ensembl:ENSRNOT00000023256(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)	rgd:69235|refseq:NP_113909.1|ensembl:ENSRNOG00000020533(gene)|ensembl:ENSRNOT00000027860(transcript)|go:"GO:0001890"(placenta development)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005520"(insulin-like growth factor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006508"(proteolysis)|go:"GO:0008236"(serine-type peptidase activity)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0042802"(identical protein binding)|go:"GO:0050679"(positive regulation of epithelial cell proliferation)|go:"GO:0050687"(negative regulation of defense response to virus)|go:"GO:0060718"(chorionic trophoblast cell differentiation)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0097187"(dentinogenesis)|interpro:IPR000867(Insulin-like growth factor-binding protein, IGFBP)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001940(Peptidase S1C, HrtA/DegP2/Q/S)|interpro:IPR002350(Proteinase inhibitor I1, Kazal)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR036034|interpro:IPR036058|interpro:IPR041489|reactome:R-RNO-1474228	-	-	-	caution:"The participant EBI-349571(P68370) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919386(Q7TP47) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920972(Q5XIP9) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-916419(P11980) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919578(Q8R491) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920554(Q5U3Z7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920647(Q5U2X8) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920585(Q7TP24) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-779677(P05426) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-915744(P02454) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|agonist:Insulin was shown to increase or decrease GLUT4 protein interactions in specific cases.|comment:"Insulin decreased GLUT4 interactions with the following proteins: Q9ER30 (Sarcosin), P09527 (Rab-7), O88960 (N-ethylmaleimide sensitive), P09456 (PKA I regulatory subunit), P27881 (Hexokinase type II), P07872 (Acyl-coenzyme A oxidase), Q6DGF1 (Isocitrate dehydrogenase), Q9EQX9 (Ubiquitin-conjugating), Q63446 (Polyubiquitin), P24268 (Cathepsin D), Q91XW0 (Heat shock protein 86), Q5FVH0 (unknown), P58405 (Striatin 3), Q62667 (Major vault protein), Q66H50 (unknown), Q09167 (splicing factor), Q9JHU5 (Arfaptin 1)."|comment:"Insulin increased GLUT4 interaction with the following proteins:Q9Z1P2 (R-actinin-1), P45592 (Cofilin), Q9QXQ0 (R-actinin-4), P26473 (ADP-ribosylation factor), P26437 (ADP-ribosylation factor),   Q7TNP1 (Basigin 2), Q6P6R2 (Dihydrolipoamide dehydrogenase),   P04797 (GAPDH), Q63081 (Protein disulfide isomerase), P29457 (47 kDa heat shock protein), Q9R1J8 (Leprecan), O88638 (Putative eps protein),   Q64375 (Synaptonemal complex)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:NDPK - Interactions involving proteins containing InterPro domain IPR001564, Nucleoside diphosphate kinase, core.	taxid:10116(rat-l6)|taxid:10116(Rattus norvegicus)	-	2006/02/15	2021/11/30	rogid:PbFY2lfrty8yw40Jq7ShR7xfuV410116	rogid:XNqCaEVtjbXi6vjqe3sx4JZxomM10116	intact-crc:44F3A2176D02515F|rigid:9RVm0UBcqQF4k06RGKO89Bg16Q8	false	myc tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P19357	uniprotkb:Q9QUR2	intact:EBI-915426|uniprotkb:P97900|ensembl:ENSRNOP00000023256	intact:EBI-920064|uniprotkb:Q9QXP8|ensembl:ENSRNOP00000026394	psi-mi:glut4_rat(display_long)|uniprotkb:Glucose transporter type 4, insulin-responsive(gene name synonym)|uniprotkb:Slc2a4(gene name)|psi-mi:Slc2a4(display_short)|uniprotkb:Glut4(gene name synonym)	psi-mi:dctn4_rat(display_long)|uniprotkb:Dctn4(gene name)|psi-mi:Dctn4(display_short)|uniprotkb:Dynactin subunit p62(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Foster et al. (2006)	pubmed:16396496|mint:MINT-5218203	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-921030	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2711|refseq:NP_036883.1|refseq:XP_006246658.1|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007611"(learning or memory)|go:"GO:0007614"(short-term memory)|go:"GO:0007616"(long-term memory)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010021"(amylopectin biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031550"(positive regulation of brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044381"(glucose import in response to insulin stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046323"(glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0098694"(regulation of synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0098793"(presynapse)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002441("Glucose transporter, type 4 (GLUT4)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-189200|ensembl:ENSRNOG00000017226(gene)|ensembl:ENSRNOT00000023256(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)	rgd:71023|refseq:NP_445856.1|refseq:XP_006254845.1|ensembl:ENSRNOG00000019298(gene)|ensembl:ENSRNOT00000026394(transcript)|go:"GO:0000776"(kinetochore)|go:"GO:0000922"(spindle pole)|go:"GO:0005813"(centrosome)|go:"GO:0005868"(cytoplasmic dynein complex)|go:"GO:0005869"(dynactin complex)|go:"GO:0005938"(cell cortex)|go:"GO:0030017"(sarcomere)|go:"GO:0047485"(protein N-terminus binding)|interpro:IPR008603(Dynactin p62)|reactome:R-RNO-2132295|reactome:R-RNO-3371497|reactome:R-RNO-6807878|reactome:R-RNO-6811436	-	-	-	caution:"The participant EBI-349571(P68370) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919386(Q7TP47) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920972(Q5XIP9) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-916419(P11980) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919578(Q8R491) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920554(Q5U3Z7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920647(Q5U2X8) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920585(Q7TP24) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-779677(P05426) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-915744(P02454) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|agonist:Insulin was shown to increase or decrease GLUT4 protein interactions in specific cases.|comment:"Insulin decreased GLUT4 interactions with the following proteins: Q9ER30 (Sarcosin), P09527 (Rab-7), O88960 (N-ethylmaleimide sensitive), P09456 (PKA I regulatory subunit), P27881 (Hexokinase type II), P07872 (Acyl-coenzyme A oxidase), Q6DGF1 (Isocitrate dehydrogenase), Q9EQX9 (Ubiquitin-conjugating), Q63446 (Polyubiquitin), P24268 (Cathepsin D), Q91XW0 (Heat shock protein 86), Q5FVH0 (unknown), P58405 (Striatin 3), Q62667 (Major vault protein), Q66H50 (unknown), Q09167 (splicing factor), Q9JHU5 (Arfaptin 1)."|comment:"Insulin increased GLUT4 interaction with the following proteins:Q9Z1P2 (R-actinin-1), P45592 (Cofilin), Q9QXQ0 (R-actinin-4), P26473 (ADP-ribosylation factor), P26437 (ADP-ribosylation factor),   Q7TNP1 (Basigin 2), Q6P6R2 (Dihydrolipoamide dehydrogenase),   P04797 (GAPDH), Q63081 (Protein disulfide isomerase), P29457 (47 kDa heat shock protein), Q9R1J8 (Leprecan), O88638 (Putative eps protein),   Q64375 (Synaptonemal complex)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:NDPK - Interactions involving proteins containing InterPro domain IPR001564, Nucleoside diphosphate kinase, core.	taxid:10116(rat-l6)|taxid:10116(Rattus norvegicus)	-	2006/02/15	2021/11/30	rogid:PbFY2lfrty8yw40Jq7ShR7xfuV410116	rogid:MZ4qvk1RPvmTNO8f4soWePLSX4k10116	intact-crc:44F3A2176D02515F|rigid:9RVm0UBcqQF4k06RGKO89Bg16Q8	false	myc tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P19357	uniprotkb:Q9JMJ4	intact:EBI-915426|uniprotkb:P97900|ensembl:ENSRNOP00000023256	intact:EBI-920056|uniprotkb:Q3B7C6|ensembl:ENSRNOP00000028373	psi-mi:glut4_rat(display_long)|uniprotkb:Glucose transporter type 4, insulin-responsive(gene name synonym)|uniprotkb:Slc2a4(gene name)|psi-mi:Slc2a4(display_short)|uniprotkb:Glut4(gene name synonym)	psi-mi:prp19_rat(display_long)|uniprotkb:Prpf19(gene name)|psi-mi:Prpf19(display_short)|uniprotkb:Prp19(gene name synonym)|uniprotkb:PRP19/PSO4 homolog(gene name synonym)|uniprotkb:Neuronal differentiation-related gene protein(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase PRP19(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Foster et al. (2006)	pubmed:16396496|mint:MINT-5218203	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-921030	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2711|refseq:NP_036883.1|refseq:XP_006246658.1|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007611"(learning or memory)|go:"GO:0007614"(short-term memory)|go:"GO:0007616"(long-term memory)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010021"(amylopectin biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031550"(positive regulation of brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044381"(glucose import in response to insulin stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046323"(glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0098694"(regulation of synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0098793"(presynapse)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002441("Glucose transporter, type 4 (GLUT4)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-189200|ensembl:ENSRNOG00000017226(gene)|ensembl:ENSRNOT00000023256(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)	rgd:708496|refseq:NP_647549.2|ensembl:ENSRNOG00000020897(gene)|ensembl:ENSRNOT00000028373(transcript)|go:"GO:0000077"(DNA damage checkpoint signaling)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0000244"(spliceosomal tri-snRNP complex assembly)|go:"GO:0000245"(spliceosomal complex assembly)|go:"GO:0000349"(generation of catalytic spliceosome for first transesterification step)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0000974"(Prp19 complex)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005662"(DNA replication factor A complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005811"(lipid droplet)|go:"GO:0005819"(spindle)|go:"GO:0006303"(double-strand break repair via nonhomologous end joining)|go:"GO:0008610"(lipid biosynthetic process)|go:"GO:0010498"(proteasomal protein catabolic process)|go:"GO:0016607"(nuclear speck)|go:"GO:0034450"(ubiquitin-ubiquitin ligase activity)|go:"GO:0034613"(cellular protein localization)|go:"GO:0035861"(site of double-strand break)|go:"GO:0042802"(identical protein binding)|go:"GO:0045666"(positive regulation of neuron differentiation)|go:"GO:0048026"(positive regulation of mRNA splicing, via spliceosome)|go:"GO:0048711"(positive regulation of astrocyte differentiation)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070534"(protein K63-linked ubiquitination)|go:"GO:0071006"(U2-type catalytic step 1 spliceosome)|go:"GO:0071007"(U2-type catalytic step 2 spliceosome)|go:"GO:0071013"(catalytic step 2 spliceosome)|interpro:IPR000772(Ricin B lectin)|interpro:IPR001680(WD40 repeat)|interpro:IPR003613(U box)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR013915(Pre-mRNA-splicing factor 19)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR020472|interpro:IPR036322|interpro:IPR038959|mint:Q9JMJ4|reactome:R-RNO-6781823|reactome:R-RNO-6782135|reactome:R-RNO-6782210|reactome:R-RNO-72163	-	-	-	caution:"The participant EBI-349571(P68370) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919386(Q7TP47) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920972(Q5XIP9) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-916419(P11980) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919578(Q8R491) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920554(Q5U3Z7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920647(Q5U2X8) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920585(Q7TP24) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-779677(P05426) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-915744(P02454) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|agonist:Insulin was shown to increase or decrease GLUT4 protein interactions in specific cases.|comment:"Insulin decreased GLUT4 interactions with the following proteins: Q9ER30 (Sarcosin), P09527 (Rab-7), O88960 (N-ethylmaleimide sensitive), P09456 (PKA I regulatory subunit), P27881 (Hexokinase type II), P07872 (Acyl-coenzyme A oxidase), Q6DGF1 (Isocitrate dehydrogenase), Q9EQX9 (Ubiquitin-conjugating), Q63446 (Polyubiquitin), P24268 (Cathepsin D), Q91XW0 (Heat shock protein 86), Q5FVH0 (unknown), P58405 (Striatin 3), Q62667 (Major vault protein), Q66H50 (unknown), Q09167 (splicing factor), Q9JHU5 (Arfaptin 1)."|comment:"Insulin increased GLUT4 interaction with the following proteins:Q9Z1P2 (R-actinin-1), P45592 (Cofilin), Q9QXQ0 (R-actinin-4), P26473 (ADP-ribosylation factor), P26437 (ADP-ribosylation factor),   Q7TNP1 (Basigin 2), Q6P6R2 (Dihydrolipoamide dehydrogenase),   P04797 (GAPDH), Q63081 (Protein disulfide isomerase), P29457 (47 kDa heat shock protein), Q9R1J8 (Leprecan), O88638 (Putative eps protein),   Q64375 (Synaptonemal complex)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:NDPK - Interactions involving proteins containing InterPro domain IPR001564, Nucleoside diphosphate kinase, core.	taxid:10116(rat-l6)|taxid:10116(Rattus norvegicus)	-	2006/02/15	2021/11/30	rogid:PbFY2lfrty8yw40Jq7ShR7xfuV410116	rogid:y9TwQBT+caDGqphA61AR5ysoqRg10116	intact-crc:44F3A2176D02515F|rigid:9RVm0UBcqQF4k06RGKO89Bg16Q8	false	myc tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P19357	uniprotkb:Q9JMB5	intact:EBI-915426|uniprotkb:P97900|ensembl:ENSRNOP00000023256	intact:EBI-920050|uniprotkb:Q6P795|ensembl:ENSRNOP00000074216	psi-mi:glut4_rat(display_long)|uniprotkb:Glucose transporter type 4, insulin-responsive(gene name synonym)|uniprotkb:Slc2a4(gene name)|psi-mi:Slc2a4(display_short)|uniprotkb:Glut4(gene name synonym)	psi-mi:adrm1_rat(display_long)|uniprotkb:Rpn13 homolog(gene name synonym)|uniprotkb:Adrm1(gene name)|psi-mi:Adrm1(display_short)|uniprotkb:Gp110(gene name synonym)|uniprotkb:Adhesion-regulating molecule 1(gene name synonym)|uniprotkb:110 kDa cell membrane glycoprotein(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Foster et al. (2006)	pubmed:16396496|mint:MINT-5218203	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-921030	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2711|refseq:NP_036883.1|refseq:XP_006246658.1|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007611"(learning or memory)|go:"GO:0007614"(short-term memory)|go:"GO:0007616"(long-term memory)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010021"(amylopectin biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031550"(positive regulation of brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044381"(glucose import in response to insulin stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046323"(glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0098694"(regulation of synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0098793"(presynapse)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002441("Glucose transporter, type 4 (GLUT4)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-189200|ensembl:ENSRNOG00000017226(gene)|ensembl:ENSRNOT00000023256(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)	rgd:69248|refseq:NP_113896.1|ensembl:ENSRNOG00000055984(gene)|ensembl:ENSRNOT00000091941(transcript)|go:"GO:0000502"(proteasome complex)|go:"GO:0001541"(ovarian follicle development)|go:"GO:0002020"(protease binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006368"(transcription elongation from RNA polymerase II promoter)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0007286"(spermatid development)|go:"GO:0008541"(proteasome regulatory particle, lid subcomplex)|go:"GO:0033081"(regulation of T cell differentiation in thymus)|go:"GO:0042699"(follicle-stimulating hormone signaling pathway)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0043248"(proteasome assembly)|go:"GO:0048477"(oogenesis)|go:"GO:0048538"(thymus development)|go:"GO:0060009"(Sertoli cell development)|go:"GO:0060399"(positive regulation of growth hormone receptor signaling pathway)|go:"GO:0060612"(adipose tissue development)|go:"GO:0061133"(endopeptidase activator activity)|go:"GO:0070628"(proteasome binding)|go:"GO:0072520"(seminiferous tubule development)|interpro:IPR006773(Adhesion regulating molecule)|interpro:IPR032368|interpro:IPR038108|interpro:IPR038633|interpro:IPR044867|interpro:IPR044868|reactome:R-RNO-5689603|reactome:R-RNO-5689880	-	-	-	caution:"The participant EBI-349571(P68370) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919386(Q7TP47) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920972(Q5XIP9) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-916419(P11980) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919578(Q8R491) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920554(Q5U3Z7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920647(Q5U2X8) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920585(Q7TP24) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-779677(P05426) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-915744(P02454) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|agonist:Insulin was shown to increase or decrease GLUT4 protein interactions in specific cases.|comment:"Insulin decreased GLUT4 interactions with the following proteins: Q9ER30 (Sarcosin), P09527 (Rab-7), O88960 (N-ethylmaleimide sensitive), P09456 (PKA I regulatory subunit), P27881 (Hexokinase type II), P07872 (Acyl-coenzyme A oxidase), Q6DGF1 (Isocitrate dehydrogenase), Q9EQX9 (Ubiquitin-conjugating), Q63446 (Polyubiquitin), P24268 (Cathepsin D), Q91XW0 (Heat shock protein 86), Q5FVH0 (unknown), P58405 (Striatin 3), Q62667 (Major vault protein), Q66H50 (unknown), Q09167 (splicing factor), Q9JHU5 (Arfaptin 1)."|comment:"Insulin increased GLUT4 interaction with the following proteins:Q9Z1P2 (R-actinin-1), P45592 (Cofilin), Q9QXQ0 (R-actinin-4), P26473 (ADP-ribosylation factor), P26437 (ADP-ribosylation factor),   Q7TNP1 (Basigin 2), Q6P6R2 (Dihydrolipoamide dehydrogenase),   P04797 (GAPDH), Q63081 (Protein disulfide isomerase), P29457 (47 kDa heat shock protein), Q9R1J8 (Leprecan), O88638 (Putative eps protein),   Q64375 (Synaptonemal complex)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:NDPK - Interactions involving proteins containing InterPro domain IPR001564, Nucleoside diphosphate kinase, core.	taxid:10116(rat-l6)|taxid:10116(Rattus norvegicus)	-	2006/02/15	2021/11/30	rogid:PbFY2lfrty8yw40Jq7ShR7xfuV410116	rogid:CQBmTir5Kk0hOsrdKfl0hpiIkxQ10116	intact-crc:44F3A2176D02515F|rigid:9RVm0UBcqQF4k06RGKO89Bg16Q8	false	myc tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P19357	uniprotkb:Q9JLZ1	intact:EBI-915426|uniprotkb:P97900|ensembl:ENSRNOP00000023256	intact:EBI-920029|uniprotkb:Q5RK11|ensembl:ENSRNOP00000022406	psi-mi:glut4_rat(display_long)|uniprotkb:Glucose transporter type 4, insulin-responsive(gene name synonym)|uniprotkb:Slc2a4(gene name)|psi-mi:Slc2a4(display_short)|uniprotkb:Glut4(gene name synonym)	psi-mi:glrx3_rat(display_long)|uniprotkb:Picot(gene name synonym)|uniprotkb:Glrx3(gene name)|psi-mi:Glrx3(display_short)|uniprotkb:Thioredoxin-like protein 2(gene name synonym)|uniprotkb:PKC-interacting cousin of thioredoxin(gene name synonym)|uniprotkb:PKC-theta-interacting protein(gene name synonym)|uniprotkb:Txnl2(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Foster et al. (2006)	pubmed:16396496|mint:MINT-5218203	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-921030	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2711|refseq:NP_036883.1|refseq:XP_006246658.1|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007611"(learning or memory)|go:"GO:0007614"(short-term memory)|go:"GO:0007616"(long-term memory)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010021"(amylopectin biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031550"(positive regulation of brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044381"(glucose import in response to insulin stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046323"(glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0098694"(regulation of synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0098793"(presynapse)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002441("Glucose transporter, type 4 (GLUT4)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-189200|ensembl:ENSRNOG00000017226(gene)|ensembl:ENSRNOT00000023256(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)	rgd:69414|refseq:NP_116003.2|ensembl:ENSRNOG00000016227(gene)|ensembl:ENSRNOT00000022406(transcript)|go:"GO:0002026"(regulation of the force of heart contraction)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0005938"(cell cortex)|go:"GO:0006879"(cellular iron ion homeostasis)|go:"GO:0010614"(negative regulation of cardiac muscle hypertrophy)|go:"GO:0030018"(Z disc)|go:"GO:0030425"(dendrite)|go:"GO:0042802"(identical protein binding)|go:"GO:0044571"([2Fe-2S] cluster assembly)|go:"GO:0046872"(metal ion binding)|go:"GO:0051536"(iron-sulfur cluster binding)|go:"GO:0097428"(protein maturation by iron-sulfur cluster transfer)|go:"GO:0097573"(glutathione oxidoreductase activity)|interpro:IPR002109(Glutaredoxin)|interpro:IPR004480(Glutaredoxin-related protein)|interpro:IPR013766(Thioredoxin domain)|interpro:IPR033658|interpro:IPR036249	-	-	-	caution:"The participant EBI-349571(P68370) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919386(Q7TP47) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920972(Q5XIP9) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-916419(P11980) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919578(Q8R491) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920554(Q5U3Z7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920647(Q5U2X8) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920585(Q7TP24) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-779677(P05426) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-915744(P02454) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|agonist:Insulin was shown to increase or decrease GLUT4 protein interactions in specific cases.|comment:"Insulin decreased GLUT4 interactions with the following proteins: Q9ER30 (Sarcosin), P09527 (Rab-7), O88960 (N-ethylmaleimide sensitive), P09456 (PKA I regulatory subunit), P27881 (Hexokinase type II), P07872 (Acyl-coenzyme A oxidase), Q6DGF1 (Isocitrate dehydrogenase), Q9EQX9 (Ubiquitin-conjugating), Q63446 (Polyubiquitin), P24268 (Cathepsin D), Q91XW0 (Heat shock protein 86), Q5FVH0 (unknown), P58405 (Striatin 3), Q62667 (Major vault protein), Q66H50 (unknown), Q09167 (splicing factor), Q9JHU5 (Arfaptin 1)."|comment:"Insulin increased GLUT4 interaction with the following proteins:Q9Z1P2 (R-actinin-1), P45592 (Cofilin), Q9QXQ0 (R-actinin-4), P26473 (ADP-ribosylation factor), P26437 (ADP-ribosylation factor),   Q7TNP1 (Basigin 2), Q6P6R2 (Dihydrolipoamide dehydrogenase),   P04797 (GAPDH), Q63081 (Protein disulfide isomerase), P29457 (47 kDa heat shock protein), Q9R1J8 (Leprecan), O88638 (Putative eps protein),   Q64375 (Synaptonemal complex)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:NDPK - Interactions involving proteins containing InterPro domain IPR001564, Nucleoside diphosphate kinase, core.	taxid:10116(rat-l6)|taxid:10116(Rattus norvegicus)	-	2006/02/15	2021/11/30	rogid:PbFY2lfrty8yw40Jq7ShR7xfuV410116	rogid:py4tsT0w45zn5Ip6mQx+0cwqsds10116	intact-crc:44F3A2176D02515F|rigid:9RVm0UBcqQF4k06RGKO89Bg16Q8	false	myc tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P19357	uniprotkb:Q9JLH7	intact:EBI-915426|uniprotkb:P97900|ensembl:ENSRNOP00000023256	intact:EBI-307845	psi-mi:glut4_rat(display_long)|uniprotkb:Glucose transporter type 4, insulin-responsive(gene name synonym)|uniprotkb:Slc2a4(gene name)|psi-mi:Slc2a4(display_short)|uniprotkb:Glut4(gene name synonym)	psi-mi:ck5p3_rat(display_long)|uniprotkb:Cdk5rap3(gene name)|psi-mi:Cdk5rap3(display_short)|uniprotkb:CDK5 activator-binding protein C53(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Foster et al. (2006)	pubmed:16396496|mint:MINT-5218203	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-921030	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2711|refseq:NP_036883.1|refseq:XP_006246658.1|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007611"(learning or memory)|go:"GO:0007614"(short-term memory)|go:"GO:0007616"(long-term memory)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010021"(amylopectin biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031550"(positive regulation of brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044381"(glucose import in response to insulin stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046323"(glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0098694"(regulation of synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0098793"(presynapse)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002441("Glucose transporter, type 4 (GLUT4)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-189200|ensembl:ENSRNOG00000017226(gene)|ensembl:ENSRNOT00000023256(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)	interpro:IPR008491(Protein of unknown function DUF773)|rgd:620002|go:"GO:0000079"(regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0001889"(liver development)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0007095"(mitotic G2 DNA damage checkpoint signaling)|go:"GO:0007346"(regulation of mitotic cell cycle)|go:"GO:0007420"(brain development)|go:"GO:0008283"(cell population proliferation)|go:"GO:0010921"(regulation of phosphatase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030332"(cyclin binding)|go:"GO:0030968"(endoplasmic reticulum unfolded protein response)|go:"GO:0030262"(apoptotic nuclear changes)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0043407"(negative regulation of MAP kinase activity)|go:"GO:0044387"(negative regulation of protein kinase activity by regulation of protein phosphorylation)|go:"GO:0044389"(ubiquitin-like protein ligase binding)|go:"GO:0044818"(mitotic G2/M transition checkpoint)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045736"(negative regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0051019"(mitogen-activated protein kinase binding)|go:"GO:0051059"(NF-kappaB binding)|go:"GO:0060318"(definitive erythrocyte differentiation)|go:"GO:0071569"(protein ufmylation)|go:"GO:0071901"(negative regulation of protein serine/threonine kinase activity)|go:"GO:0097371"(MDM2/MDM4 family protein binding)|go:"GO:1900182"(positive regulation of protein localization to nucleus)|go:"GO:1901798"(positive regulation of signal transduction by p53 class mediator)|go:"GO:1903363"(negative regulation of cellular protein catabolic process)	-	-	-	caution:"The participant EBI-349571(P68370) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919386(Q7TP47) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920972(Q5XIP9) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-916419(P11980) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919578(Q8R491) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920554(Q5U3Z7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920647(Q5U2X8) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920585(Q7TP24) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-779677(P05426) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-915744(P02454) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|agonist:Insulin was shown to increase or decrease GLUT4 protein interactions in specific cases.|comment:"Insulin decreased GLUT4 interactions with the following proteins: Q9ER30 (Sarcosin), P09527 (Rab-7), O88960 (N-ethylmaleimide sensitive), P09456 (PKA I regulatory subunit), P27881 (Hexokinase type II), P07872 (Acyl-coenzyme A oxidase), Q6DGF1 (Isocitrate dehydrogenase), Q9EQX9 (Ubiquitin-conjugating), Q63446 (Polyubiquitin), P24268 (Cathepsin D), Q91XW0 (Heat shock protein 86), Q5FVH0 (unknown), P58405 (Striatin 3), Q62667 (Major vault protein), Q66H50 (unknown), Q09167 (splicing factor), Q9JHU5 (Arfaptin 1)."|comment:"Insulin increased GLUT4 interaction with the following proteins:Q9Z1P2 (R-actinin-1), P45592 (Cofilin), Q9QXQ0 (R-actinin-4), P26473 (ADP-ribosylation factor), P26437 (ADP-ribosylation factor),   Q7TNP1 (Basigin 2), Q6P6R2 (Dihydrolipoamide dehydrogenase),   P04797 (GAPDH), Q63081 (Protein disulfide isomerase), P29457 (47 kDa heat shock protein), Q9R1J8 (Leprecan), O88638 (Putative eps protein),   Q64375 (Synaptonemal complex)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:NDPK - Interactions involving proteins containing InterPro domain IPR001564, Nucleoside diphosphate kinase, core.	taxid:10116(rat-l6)|taxid:10116(Rattus norvegicus)	-	2006/02/15	2021/11/30	rogid:PbFY2lfrty8yw40Jq7ShR7xfuV410116	rogid:NByIIIZDrcnUq199ofAknxV/u+s10116	intact-crc:44F3A2176D02515F|rigid:9RVm0UBcqQF4k06RGKO89Bg16Q8	false	myc tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P19357	uniprotkb:Q9JLA3	intact:EBI-915426|uniprotkb:P97900|ensembl:ENSRNOP00000023256	intact:EBI-920013|ensembl:ENSRNOP00000020558	psi-mi:glut4_rat(display_long)|uniprotkb:Glucose transporter type 4, insulin-responsive(gene name synonym)|uniprotkb:Slc2a4(gene name)|psi-mi:Slc2a4(display_short)|uniprotkb:Glut4(gene name synonym)	psi-mi:uggg1_rat(display_long)|uniprotkb:Ugcgl1(gene name synonym)|uniprotkb:Uggt1(gene name)|psi-mi:Uggt1(display_short)|uniprotkb:Gt(gene name synonym)|uniprotkb:Uggt(gene name synonym)|uniprotkb:Ugt1(gene name synonym)|uniprotkb:Ugtr(gene name synonym)|uniprotkb:UDP-glucose ceramide glucosyltransferase-like 1(gene name synonym)|uniprotkb:"UDP--Glc:glycoprotein glucosyltransferase"(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Foster et al. (2006)	pubmed:16396496|mint:MINT-5218203	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-921030	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2711|refseq:NP_036883.1|refseq:XP_006246658.1|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007611"(learning or memory)|go:"GO:0007614"(short-term memory)|go:"GO:0007616"(long-term memory)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010021"(amylopectin biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031550"(positive regulation of brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044381"(glucose import in response to insulin stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046323"(glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0098694"(regulation of synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0098793"(presynapse)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002441("Glucose transporter, type 4 (GLUT4)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-189200|ensembl:ENSRNOG00000017226(gene)|ensembl:ENSRNOT00000023256(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)	rgd:619710|refseq:NP_598280.1|refseq:XP_006244796.1|ensembl:ENSRNOG00000014901(gene)|ensembl:ENSRNOT00000020558(transcript)|go:"GO:0003980"("UDP-glucose:glycoprotein glucosyltransferase activity")|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005793"(endoplasmic reticulum-Golgi intermediate compartment)|go:"GO:0006457"(protein folding)|go:"GO:0018279"(protein N-linked glycosylation via asparagine)|go:"GO:0032991"(protein-containing complex)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051084"('de novo' posttranslational protein folding)|go:"GO:0071712"(ER-associated misfolded protein catabolic process)|interpro:IPR009448("UDP-glucose:Glycoprotein Glucosyltransferase")|interpro:IPR029044|interpro:IPR040497|interpro:IPR040525|interpro:IPR040692|interpro:IPR040693|interpro:IPR040694	-	-	-	caution:"The participant EBI-349571(P68370) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919386(Q7TP47) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920972(Q5XIP9) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-916419(P11980) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919578(Q8R491) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920554(Q5U3Z7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920647(Q5U2X8) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920585(Q7TP24) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-779677(P05426) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-915744(P02454) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|agonist:Insulin was shown to increase or decrease GLUT4 protein interactions in specific cases.|comment:"Insulin decreased GLUT4 interactions with the following proteins: Q9ER30 (Sarcosin), P09527 (Rab-7), O88960 (N-ethylmaleimide sensitive), P09456 (PKA I regulatory subunit), P27881 (Hexokinase type II), P07872 (Acyl-coenzyme A oxidase), Q6DGF1 (Isocitrate dehydrogenase), Q9EQX9 (Ubiquitin-conjugating), Q63446 (Polyubiquitin), P24268 (Cathepsin D), Q91XW0 (Heat shock protein 86), Q5FVH0 (unknown), P58405 (Striatin 3), Q62667 (Major vault protein), Q66H50 (unknown), Q09167 (splicing factor), Q9JHU5 (Arfaptin 1)."|comment:"Insulin increased GLUT4 interaction with the following proteins:Q9Z1P2 (R-actinin-1), P45592 (Cofilin), Q9QXQ0 (R-actinin-4), P26473 (ADP-ribosylation factor), P26437 (ADP-ribosylation factor),   Q7TNP1 (Basigin 2), Q6P6R2 (Dihydrolipoamide dehydrogenase),   P04797 (GAPDH), Q63081 (Protein disulfide isomerase), P29457 (47 kDa heat shock protein), Q9R1J8 (Leprecan), O88638 (Putative eps protein),   Q64375 (Synaptonemal complex)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:NDPK - Interactions involving proteins containing InterPro domain IPR001564, Nucleoside diphosphate kinase, core.	taxid:10116(rat-l6)|taxid:10116(Rattus norvegicus)	-	2006/02/15	2021/11/30	rogid:PbFY2lfrty8yw40Jq7ShR7xfuV410116	rogid:5T+wiBDw2POAICLgez1LxozzrtU10116	intact-crc:44F3A2176D02515F|rigid:9RVm0UBcqQF4k06RGKO89Bg16Q8	false	myc tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P19357	uniprotkb:Q9JK11	intact:EBI-915426|uniprotkb:P97900|ensembl:ENSRNOP00000023256	intact:EBI-919972|uniprotkb:Q9JK10|uniprotkb:Q9R0D9|uniprotkb:Q9WUE9|uniprotkb:Q9WUF0	psi-mi:glut4_rat(display_long)|uniprotkb:Glucose transporter type 4, insulin-responsive(gene name synonym)|uniprotkb:Slc2a4(gene name)|psi-mi:Slc2a4(display_short)|uniprotkb:Glut4(gene name synonym)	psi-mi:rtn4_rat(display_long)|uniprotkb:Rtn4(gene name)|psi-mi:Rtn4(display_short)|uniprotkb:Nogo(gene name synonym)|uniprotkb:Neurite outgrowth inhibitor(gene name synonym)|uniprotkb:Foocen(gene name synonym)|uniprotkb:Glut4 vesicle 20 kDa protein(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Foster et al. (2006)	pubmed:16396496|mint:MINT-5218203	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-921030	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2711|refseq:NP_036883.1|refseq:XP_006246658.1|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007611"(learning or memory)|go:"GO:0007614"(short-term memory)|go:"GO:0007616"(long-term memory)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010021"(amylopectin biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031550"(positive regulation of brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044381"(glucose import in response to insulin stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046323"(glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0098694"(regulation of synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0098793"(presynapse)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002441("Glucose transporter, type 4 (GLUT4)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-189200|ensembl:ENSRNOG00000017226(gene)|ensembl:ENSRNOT00000023256(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)	rgd:620989|refseq:NP_114019.1|refseq:XP_006251671.1|refseq:XP_006251670.2|mint:Q9JK11|refseq:XP_017454882.1|dip:DIP-37179N|go:"GO:0001825"(blastocyst formation)|go:"GO:0002523"(leukocyte migration involved in inflammatory response)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0007399"(nervous system development)|go:"GO:0007413"(axonal fasciculation)|go:"GO:0007568"(aging)|go:"GO:0010634"(positive regulation of epithelial cell migration)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0014823"(response to activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0021553"(olfactory nerve development)|go:"GO:0021801"(cerebral cortex radial glia-guided migration)|go:"GO:0022009"(central nervous system vasculogenesis)|go:"GO:0030054"(cell junction)|go:"GO:0030176"(integral component of endoplasmic reticulum membrane)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030517"(negative regulation of axon extension)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033601"(positive regulation of mammary gland epithelial cell proliferation)|go:"GO:0033603"(positive regulation of dopamine secretion)|go:"GO:0034165"(positive regulation of toll-like receptor 9 signaling pathway)|go:"GO:0035022"(positive regulation of Rac protein signal transduction)|go:"GO:0035441"(cell migration involved in vasculogenesis)|go:"GO:0042995"(cell projection)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043209"(myelin sheath)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0045687"(positive regulation of glial cell differentiation)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0048709"(oligodendrocyte differentiation)|go:"GO:0050771"(negative regulation of axonogenesis)|go:"GO:0050821"(protein stabilization)|go:"GO:0051292"(nuclear pore complex assembly)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0051930"(regulation of sensory perception of pain)|go:"GO:0051960"(regulation of nervous system development)|go:"GO:0060317"(cardiac epithelial to mesenchymal transition)|go:"GO:0060907"(positive regulation of macrophage cytokine production)|go:"GO:0061462"(protein localization to lysosome)|go:"GO:0070571"(negative regulation of neuron projection regeneration)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071782"(endoplasmic reticulum tubular network)|go:"GO:0071786"(endoplasmic reticulum tubular network organization)|go:"GO:0071787"(endoplasmic reticulum tubular network formation)|go:"GO:0090156"(cellular sphingolipid homeostasis)|go:"GO:0098826"(endoplasmic reticulum tubular network membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099061"(integral component of postsynaptic density membrane)|go:"GO:0120078"(cell adhesion involved in sprouting angiogenesis)|go:"GO:1902430"(negative regulation of amyloid-beta formation)|go:"GO:1902624"(positive regulation of neutrophil migration)|go:"GO:1905523"(positive regulation of macrophage migration)|go:"GO:1905552"(positive regulation of protein localization to endoplasmic reticulum)|go:"GO:1905580"(positive regulation of ERBB3 signaling pathway)|go:"GO:1905653"(positive regulation of artery morphogenesis)|go:"GO:1990809"(endoplasmic reticulum tubular network membrane organization)|go:"GO:2000172"(regulation of branching morphogenesis of a nerve)|go:"GO:2000347"(positive regulation of hepatocyte proliferation)|go:"GO:2001213"(negative regulation of vasculogenesis)|interpro:IPR003388(Reticulon)|reactome:R-RNO-193634	-	-	-	caution:"The participant EBI-349571(P68370) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919386(Q7TP47) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920972(Q5XIP9) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-916419(P11980) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919578(Q8R491) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920554(Q5U3Z7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920647(Q5U2X8) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920585(Q7TP24) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-779677(P05426) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-915744(P02454) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|agonist:Insulin was shown to increase or decrease GLUT4 protein interactions in specific cases.|comment:"Insulin decreased GLUT4 interactions with the following proteins: Q9ER30 (Sarcosin), P09527 (Rab-7), O88960 (N-ethylmaleimide sensitive), P09456 (PKA I regulatory subunit), P27881 (Hexokinase type II), P07872 (Acyl-coenzyme A oxidase), Q6DGF1 (Isocitrate dehydrogenase), Q9EQX9 (Ubiquitin-conjugating), Q63446 (Polyubiquitin), P24268 (Cathepsin D), Q91XW0 (Heat shock protein 86), Q5FVH0 (unknown), P58405 (Striatin 3), Q62667 (Major vault protein), Q66H50 (unknown), Q09167 (splicing factor), Q9JHU5 (Arfaptin 1)."|comment:"Insulin increased GLUT4 interaction with the following proteins:Q9Z1P2 (R-actinin-1), P45592 (Cofilin), Q9QXQ0 (R-actinin-4), P26473 (ADP-ribosylation factor), P26437 (ADP-ribosylation factor),   Q7TNP1 (Basigin 2), Q6P6R2 (Dihydrolipoamide dehydrogenase),   P04797 (GAPDH), Q63081 (Protein disulfide isomerase), P29457 (47 kDa heat shock protein), Q9R1J8 (Leprecan), O88638 (Putative eps protein),   Q64375 (Synaptonemal complex)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:NDPK - Interactions involving proteins containing InterPro domain IPR001564, Nucleoside diphosphate kinase, core.	taxid:10116(rat-l6)|taxid:10116(Rattus norvegicus)	-	2006/02/15	2021/11/30	rogid:PbFY2lfrty8yw40Jq7ShR7xfuV410116	rogid:CEWzvhKyKl/Cdz7MmociJDKwNPk10116	intact-crc:44F3A2176D02515F|rigid:9RVm0UBcqQF4k06RGKO89Bg16Q8	false	myc tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P19357	uniprotkb:Q9JIJ7	intact:EBI-915426|uniprotkb:P97900|ensembl:ENSRNOP00000023256	intact:EBI-919960	psi-mi:glut4_rat(display_long)|uniprotkb:Glucose transporter type 4, insulin-responsive(gene name synonym)|uniprotkb:Slc2a4(gene name)|psi-mi:Slc2a4(display_short)|uniprotkb:Glut4(gene name synonym)	psi-mi:q9jij7_rat(display_long)|uniprotkb:Ddx1(gene name)|psi-mi:Ddx1(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Foster et al. (2006)	pubmed:16396496|mint:MINT-5218203	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-921030	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2711|refseq:NP_036883.1|refseq:XP_006246658.1|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007611"(learning or memory)|go:"GO:0007614"(short-term memory)|go:"GO:0007616"(long-term memory)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010021"(amylopectin biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031550"(positive regulation of brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044381"(glucose import in response to insulin stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046323"(glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0098694"(regulation of synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0098793"(presynapse)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002441("Glucose transporter, type 4 (GLUT4)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-189200|ensembl:ENSRNOG00000017226(gene)|ensembl:ENSRNOT00000023256(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)	interpro:IPR001870("B302 (SPRY)-like")|interpro:IPR011545(DNA/RNA helicase, DEAD/DEAH box type, N-terminal)|interpro:IPR003877(SPla/RYanodine receptor SPRY)|interpro:IPR027417|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR043136|go:"GO:0003676"(nucleic acid binding)|go:"GO:0004527"(exonuclease activity)|go:"GO:0005524"(ATP binding)|go:"GO:0006397"(mRNA processing)|go:"GO:0051607"(defense response to virus)	-	-	-	caution:"The participant EBI-349571(P68370) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919386(Q7TP47) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920972(Q5XIP9) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-916419(P11980) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919578(Q8R491) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920554(Q5U3Z7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920647(Q5U2X8) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920585(Q7TP24) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-779677(P05426) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-915744(P02454) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|agonist:Insulin was shown to increase or decrease GLUT4 protein interactions in specific cases.|comment:"Insulin decreased GLUT4 interactions with the following proteins: Q9ER30 (Sarcosin), P09527 (Rab-7), O88960 (N-ethylmaleimide sensitive), P09456 (PKA I regulatory subunit), P27881 (Hexokinase type II), P07872 (Acyl-coenzyme A oxidase), Q6DGF1 (Isocitrate dehydrogenase), Q9EQX9 (Ubiquitin-conjugating), Q63446 (Polyubiquitin), P24268 (Cathepsin D), Q91XW0 (Heat shock protein 86), Q5FVH0 (unknown), P58405 (Striatin 3), Q62667 (Major vault protein), Q66H50 (unknown), Q09167 (splicing factor), Q9JHU5 (Arfaptin 1)."|comment:"Insulin increased GLUT4 interaction with the following proteins:Q9Z1P2 (R-actinin-1), P45592 (Cofilin), Q9QXQ0 (R-actinin-4), P26473 (ADP-ribosylation factor), P26437 (ADP-ribosylation factor),   Q7TNP1 (Basigin 2), Q6P6R2 (Dihydrolipoamide dehydrogenase),   P04797 (GAPDH), Q63081 (Protein disulfide isomerase), P29457 (47 kDa heat shock protein), Q9R1J8 (Leprecan), O88638 (Putative eps protein),   Q64375 (Synaptonemal complex)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:NDPK - Interactions involving proteins containing InterPro domain IPR001564, Nucleoside diphosphate kinase, core.	taxid:10116(rat-l6)|taxid:10116(Rattus norvegicus)	-	2006/02/15	2021/11/30	rogid:PbFY2lfrty8yw40Jq7ShR7xfuV410116	rogid:qeg8ulKNiygTVKWHsEMXhble50c10116	intact-crc:44F3A2176D02515F|rigid:9RVm0UBcqQF4k06RGKO89Bg16Q8	false	myc tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P19357	uniprotkb:Q9JI85	intact:EBI-915426|uniprotkb:P97900|ensembl:ENSRNOP00000023256	intact:EBI-919952	psi-mi:glut4_rat(display_long)|uniprotkb:Glucose transporter type 4, insulin-responsive(gene name synonym)|uniprotkb:Slc2a4(gene name)|psi-mi:Slc2a4(display_short)|uniprotkb:Glut4(gene name synonym)	psi-mi:nucb2_rat(display_long)|uniprotkb:Nucb2(gene name)|psi-mi:Nucb2(display_short)|uniprotkb:Nefa(gene name synonym)|uniprotkb:DNA-binding protein NEFA(gene name synonym)|uniprotkb:Prepronesfatin(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Foster et al. (2006)	pubmed:16396496|mint:MINT-5218203	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-921030	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2711|refseq:NP_036883.1|refseq:XP_006246658.1|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007611"(learning or memory)|go:"GO:0007614"(short-term memory)|go:"GO:0007616"(long-term memory)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010021"(amylopectin biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031550"(positive regulation of brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044381"(glucose import in response to insulin stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046323"(glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0098694"(regulation of synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0098793"(presynapse)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002441("Glucose transporter, type 4 (GLUT4)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-189200|ensembl:ENSRNOG00000017226(gene)|ensembl:ENSRNOT00000023256(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)	rgd:620888|refseq:NP_067695.1|interpro:IPR011992(EF-Hand type)|interpro:IPR018247|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR028813|interpro:IPR040250|go:"GO:0001965"(G-protein alpha-subunit binding)|go:"GO:0003677"(DNA binding)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005164"(tumor necrosis factor receptor binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005640"(nuclear outer membrane)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005793"(endoplasmic reticulum-Golgi intermediate compartment)|go:"GO:0005797"(Golgi medial cisterna)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0009749"(response to glucose)|go:"GO:0032099"(negative regulation of appetite)|go:"GO:0042594"(response to starvation)|go:"GO:0043951"(negative regulation of cAMP-mediated signaling)|go:"GO:0044752"(response to human chorionic gonadotropin)|go:"GO:0045599"(negative regulation of fat cell differentiation)|go:"GO:0046321"(positive regulation of fatty acid oxidation)|go:"GO:0046627"(negative regulation of insulin receptor signaling pathway)|go:"GO:0070093"(negative regulation of glucagon secretion)|go:"GO:1901142"(insulin metabolic process)|go:"GO:1990680"(response to melanocyte-stimulating hormone)|go:"GO:2000845"(positive regulation of testosterone secretion)	-	-	-	caution:"The participant EBI-349571(P68370) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919386(Q7TP47) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920972(Q5XIP9) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-916419(P11980) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919578(Q8R491) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920554(Q5U3Z7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920647(Q5U2X8) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920585(Q7TP24) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-779677(P05426) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-915744(P02454) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|agonist:Insulin was shown to increase or decrease GLUT4 protein interactions in specific cases.|comment:"Insulin decreased GLUT4 interactions with the following proteins: Q9ER30 (Sarcosin), P09527 (Rab-7), O88960 (N-ethylmaleimide sensitive), P09456 (PKA I regulatory subunit), P27881 (Hexokinase type II), P07872 (Acyl-coenzyme A oxidase), Q6DGF1 (Isocitrate dehydrogenase), Q9EQX9 (Ubiquitin-conjugating), Q63446 (Polyubiquitin), P24268 (Cathepsin D), Q91XW0 (Heat shock protein 86), Q5FVH0 (unknown), P58405 (Striatin 3), Q62667 (Major vault protein), Q66H50 (unknown), Q09167 (splicing factor), Q9JHU5 (Arfaptin 1)."|comment:"Insulin increased GLUT4 interaction with the following proteins:Q9Z1P2 (R-actinin-1), P45592 (Cofilin), Q9QXQ0 (R-actinin-4), P26473 (ADP-ribosylation factor), P26437 (ADP-ribosylation factor),   Q7TNP1 (Basigin 2), Q6P6R2 (Dihydrolipoamide dehydrogenase),   P04797 (GAPDH), Q63081 (Protein disulfide isomerase), P29457 (47 kDa heat shock protein), Q9R1J8 (Leprecan), O88638 (Putative eps protein),   Q64375 (Synaptonemal complex)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:NDPK - Interactions involving proteins containing InterPro domain IPR001564, Nucleoside diphosphate kinase, core.	taxid:10116(rat-l6)|taxid:10116(Rattus norvegicus)	-	2006/02/15	2021/11/30	rogid:PbFY2lfrty8yw40Jq7ShR7xfuV410116	rogid:qwFmhTwVx/vWZku3VIPVSMlElLo10116	intact-crc:44F3A2176D02515F|rigid:9RVm0UBcqQF4k06RGKO89Bg16Q8	false	myc tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P19357	uniprotkb:Q9JHY2	intact:EBI-915426|uniprotkb:P97900|ensembl:ENSRNOP00000023256	intact:EBI-919945	psi-mi:glut4_rat(display_long)|uniprotkb:Glucose transporter type 4, insulin-responsive(gene name synonym)|uniprotkb:Slc2a4(gene name)|psi-mi:Slc2a4(display_short)|uniprotkb:Glut4(gene name synonym)	psi-mi:sfxn3_rat(display_long)|uniprotkb:Sfxn3(gene name)|psi-mi:Sfxn3(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Foster et al. (2006)	pubmed:16396496|mint:MINT-5218203	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-921030	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2711|refseq:NP_036883.1|refseq:XP_006246658.1|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007611"(learning or memory)|go:"GO:0007614"(short-term memory)|go:"GO:0007616"(long-term memory)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010021"(amylopectin biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031550"(positive regulation of brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044381"(glucose import in response to insulin stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046323"(glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0098694"(regulation of synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0098793"(presynapse)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002441("Glucose transporter, type 4 (GLUT4)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-189200|ensembl:ENSRNOG00000017226(gene)|ensembl:ENSRNOT00000023256(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)	rgd:620716|refseq:NP_075237.1|interpro:IPR004686(Tricarboxylate/iron carrier)|mint:Q9JHY2|go:"GO:0005371"(tricarboxylate secondary active transmembrane transporter activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0006730"(one-carbon metabolic process)|go:"GO:0022857"(transmembrane transporter activity)|go:"GO:0022889"(serine transmembrane transporter activity)|go:"GO:0031305"(integral component of mitochondrial inner membrane)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0140300"(serine import into mitochondrion)|go:"GO:1990542"(mitochondrial transmembrane transport)	-	-	-	caution:"The participant EBI-349571(P68370) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919386(Q7TP47) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920972(Q5XIP9) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-916419(P11980) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919578(Q8R491) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920554(Q5U3Z7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920647(Q5U2X8) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920585(Q7TP24) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-779677(P05426) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-915744(P02454) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|agonist:Insulin was shown to increase or decrease GLUT4 protein interactions in specific cases.|comment:"Insulin decreased GLUT4 interactions with the following proteins: Q9ER30 (Sarcosin), P09527 (Rab-7), O88960 (N-ethylmaleimide sensitive), P09456 (PKA I regulatory subunit), P27881 (Hexokinase type II), P07872 (Acyl-coenzyme A oxidase), Q6DGF1 (Isocitrate dehydrogenase), Q9EQX9 (Ubiquitin-conjugating), Q63446 (Polyubiquitin), P24268 (Cathepsin D), Q91XW0 (Heat shock protein 86), Q5FVH0 (unknown), P58405 (Striatin 3), Q62667 (Major vault protein), Q66H50 (unknown), Q09167 (splicing factor), Q9JHU5 (Arfaptin 1)."|comment:"Insulin increased GLUT4 interaction with the following proteins:Q9Z1P2 (R-actinin-1), P45592 (Cofilin), Q9QXQ0 (R-actinin-4), P26473 (ADP-ribosylation factor), P26437 (ADP-ribosylation factor),   Q7TNP1 (Basigin 2), Q6P6R2 (Dihydrolipoamide dehydrogenase),   P04797 (GAPDH), Q63081 (Protein disulfide isomerase), P29457 (47 kDa heat shock protein), Q9R1J8 (Leprecan), O88638 (Putative eps protein),   Q64375 (Synaptonemal complex)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:NDPK - Interactions involving proteins containing InterPro domain IPR001564, Nucleoside diphosphate kinase, core.	taxid:10116(rat-l6)|taxid:10116(Rattus norvegicus)	-	2006/02/15	2021/11/30	rogid:PbFY2lfrty8yw40Jq7ShR7xfuV410116	rogid:KXWPONNXXrT71ucMJjKuHe6V+EE10116	intact-crc:44F3A2176D02515F|rigid:9RVm0UBcqQF4k06RGKO89Bg16Q8	false	myc tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P19357	uniprotkb:Q9JHW5	intact:EBI-915426|uniprotkb:P97900|ensembl:ENSRNOP00000023256	intact:EBI-919936|ensembl:ENSRNOP00000011065	psi-mi:glut4_rat(display_long)|uniprotkb:Glucose transporter type 4, insulin-responsive(gene name synonym)|uniprotkb:Slc2a4(gene name)|psi-mi:Slc2a4(display_short)|uniprotkb:Glut4(gene name synonym)	psi-mi:vamp7_rat(display_long)|uniprotkb:Vamp7(gene name)|psi-mi:Vamp7(display_short)|uniprotkb:Sybl1(gene name synonym)|uniprotkb:Synaptobrevin-like protein 1(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Foster et al. (2006)	pubmed:16396496|mint:MINT-5218203	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-921030	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2711|refseq:NP_036883.1|refseq:XP_006246658.1|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007611"(learning or memory)|go:"GO:0007614"(short-term memory)|go:"GO:0007616"(long-term memory)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010021"(amylopectin biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031550"(positive regulation of brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044381"(glucose import in response to insulin stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046323"(glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0098694"(regulation of synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0098793"(presynapse)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002441("Glucose transporter, type 4 (GLUT4)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-189200|ensembl:ENSRNOG00000017226(gene)|ensembl:ENSRNOT00000023256(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)	rgd:621558|refseq:NP_445983.1|refseq:XP_006249078.1|dip:DIP-37175N|ensembl:ENSRNOG00000008372(gene)|ensembl:ENSRNOT00000011065(transcript)|go:"GO:0000149"(SNARE binding)|go:"GO:0005484"(SNAP receptor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005886"(plasma membrane)|go:"GO:0006887"(exocytosis)|go:"GO:0006888"(endoplasmic reticulum to Golgi vesicle-mediated transport)|go:"GO:0006906"(vesicle fusion)|go:"GO:0006911"(phagocytosis, engulfment)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008333"(endosome to lysosome transport)|go:"GO:0009986"(cell surface)|go:"GO:0016020"(membrane)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0017156"(calcium-ion regulated exocytosis)|go:"GO:0019905"(syntaxin binding)|go:"GO:0030027"(lamellipodium)|go:"GO:0030133"(transport vesicle)|go:"GO:0030141"(secretory granule)|go:"GO:0030175"(filopodium)|go:"GO:0030285"(integral component of synaptic vesicle membrane)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0030670"(phagocytic vesicle membrane)|go:"GO:0031091"(platelet alpha granule)|go:"GO:0031143"(pseudopodium)|go:"GO:0031201"(SNARE complex)|go:"GO:0031902"(late endosome membrane)|go:"GO:0034197"(triglyceride transport)|go:"GO:0035493"(SNARE complex assembly)|go:"GO:0035577"(azurophil granule membrane)|go:"GO:0043001"(Golgi to plasma membrane protein transport)|go:"GO:0043005"(neuron projection)|go:"GO:0043308"(eosinophil degranulation)|go:"GO:0043312"(neutrophil degranulation)|go:"GO:0043320"(natural killer cell degranulation)|go:"GO:0045177"(apical part of cell)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0047496"(vesicle transport along microtubule)|go:"GO:0048280"(vesicle fusion with Golgi apparatus)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050775"(positive regulation of dendrite morphogenesis)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:1900483"(regulation of protein targeting to vacuolar membrane)|go:"GO:1903595"(positive regulation of histamine secretion by mast cell)|interpro:IPR001388(Synaptobrevin)|interpro:IPR010908(Longin)|interpro:IPR011012(Longin-like)|interpro:IPR042855|mint:Q9JHW5|reactome:R-RNO-432720|reactome:R-RNO-432722|reactome:R-RNO-8856825|reactome:R-RNO-8856828	-	-	-	caution:"The participant EBI-349571(P68370) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919386(Q7TP47) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920972(Q5XIP9) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-916419(P11980) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919578(Q8R491) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920554(Q5U3Z7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920647(Q5U2X8) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920585(Q7TP24) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-779677(P05426) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-915744(P02454) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|agonist:Insulin was shown to increase or decrease GLUT4 protein interactions in specific cases.|comment:"Insulin decreased GLUT4 interactions with the following proteins: Q9ER30 (Sarcosin), P09527 (Rab-7), O88960 (N-ethylmaleimide sensitive), P09456 (PKA I regulatory subunit), P27881 (Hexokinase type II), P07872 (Acyl-coenzyme A oxidase), Q6DGF1 (Isocitrate dehydrogenase), Q9EQX9 (Ubiquitin-conjugating), Q63446 (Polyubiquitin), P24268 (Cathepsin D), Q91XW0 (Heat shock protein 86), Q5FVH0 (unknown), P58405 (Striatin 3), Q62667 (Major vault protein), Q66H50 (unknown), Q09167 (splicing factor), Q9JHU5 (Arfaptin 1)."|comment:"Insulin increased GLUT4 interaction with the following proteins:Q9Z1P2 (R-actinin-1), P45592 (Cofilin), Q9QXQ0 (R-actinin-4), P26473 (ADP-ribosylation factor), P26437 (ADP-ribosylation factor),   Q7TNP1 (Basigin 2), Q6P6R2 (Dihydrolipoamide dehydrogenase),   P04797 (GAPDH), Q63081 (Protein disulfide isomerase), P29457 (47 kDa heat shock protein), Q9R1J8 (Leprecan), O88638 (Putative eps protein),   Q64375 (Synaptonemal complex)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:NDPK - Interactions involving proteins containing InterPro domain IPR001564, Nucleoside diphosphate kinase, core.	taxid:10116(rat-l6)|taxid:10116(Rattus norvegicus)	-	2006/02/15	2021/11/30	rogid:PbFY2lfrty8yw40Jq7ShR7xfuV410116	rogid:bSSSoAnL3OD7u35tN7n6E6i1Ca010116	intact-crc:44F3A2176D02515F|rigid:9RVm0UBcqQF4k06RGKO89Bg16Q8	false	myc tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P19357	uniprotkb:Q9JHW0	intact:EBI-915426|uniprotkb:P97900|ensembl:ENSRNOP00000023256	intact:EBI-919930|ensembl:ENSRNOP00000016876|ensembl:ENSRNOP00000073989	psi-mi:glut4_rat(display_long)|uniprotkb:Glucose transporter type 4, insulin-responsive(gene name synonym)|uniprotkb:Slc2a4(gene name)|psi-mi:Slc2a4(display_short)|uniprotkb:Glut4(gene name synonym)	psi-mi:psb7_rat(display_long)|uniprotkb:Psmb7(gene name)|psi-mi:Psmb7(display_short)|uniprotkb:Proteasome subunit Z(gene name synonym)|uniprotkb:Macropain chain Z(gene name synonym)|uniprotkb:Multicatalytic endopeptidase complex chain Z(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Foster et al. (2006)	pubmed:16396496|mint:MINT-5218203	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-921030	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2711|refseq:NP_036883.1|refseq:XP_006246658.1|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007611"(learning or memory)|go:"GO:0007614"(short-term memory)|go:"GO:0007616"(long-term memory)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010021"(amylopectin biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031550"(positive regulation of brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044381"(glucose import in response to insulin stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046323"(glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0098694"(regulation of synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0098793"(presynapse)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002441("Glucose transporter, type 4 (GLUT4)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-189200|ensembl:ENSRNOG00000017226(gene)|ensembl:ENSRNOT00000023256(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)	rgd:621093|refseq:NP_445984.1|ensembl:ENSRNOG00000011732(gene)|ensembl:ENSRNOT00000016876(transcript)|ensembl:ENSRNOT00000085981(transcript)|go:"GO:0000502"(proteasome complex)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004298"(threonine-type endopeptidase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005839"(proteasome core complex)|go:"GO:0010499"(proteasomal ubiquitin-independent protein catabolic process)|go:"GO:0019774"(proteasome core complex, beta-subunit complex)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|interpro:IPR000243(Peptidase T1A, proteasome beta-subunit)|interpro:IPR001353(20S proteasome, A and B subunits)|interpro:IPR016050(Proteasome, beta-type subunit, conserved site)|interpro:IPR023333|interpro:IPR024689|interpro:IPR029055|interpro:IPR035216|rcsb pdb:6EPC|rcsb pdb:6EPD|rcsb pdb:6EPE|rcsb pdb:6EPF|rcsb pdb:6TU3|reactome:R-RNO-1169091|reactome:R-RNO-1234176|reactome:R-RNO-1236978|reactome:R-RNO-174084|reactome:R-RNO-174154|reactome:R-RNO-174178|reactome:R-RNO-174184|reactome:R-RNO-187577|reactome:R-RNO-195253|reactome:R-RNO-2467813|reactome:R-RNO-349425|reactome:R-RNO-350562|reactome:R-RNO-382556|reactome:R-RNO-450408|reactome:R-RNO-4608870|reactome:R-RNO-4641257|reactome:R-RNO-4641258|reactome:R-RNO-5358346|reactome:R-RNO-5607761|reactome:R-RNO-5610780|reactome:R-RNO-5610785|reactome:R-RNO-5632684|reactome:R-RNO-5658442|reactome:R-RNO-5668541|reactome:R-RNO-5676590|reactome:R-RNO-5687128|reactome:R-RNO-5689603|reactome:R-RNO-5689880|reactome:R-RNO-6798695|reactome:R-RNO-68827|reactome:R-RNO-68949|reactome:R-RNO-69017|reactome:R-RNO-69481|reactome:R-RNO-69601|reactome:R-RNO-75815|reactome:R-RNO-8852276|reactome:R-RNO-8854050|reactome:R-RNO-8932339|reactome:R-RNO-8939236|reactome:R-RNO-8941858|reactome:R-RNO-8948751|reactome:R-RNO-8951664|reactome:R-RNO-983168	-	-	-	caution:"The participant EBI-349571(P68370) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919386(Q7TP47) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920972(Q5XIP9) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-916419(P11980) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919578(Q8R491) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920554(Q5U3Z7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920647(Q5U2X8) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920585(Q7TP24) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-779677(P05426) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-915744(P02454) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|agonist:Insulin was shown to increase or decrease GLUT4 protein interactions in specific cases.|comment:"Insulin decreased GLUT4 interactions with the following proteins: Q9ER30 (Sarcosin), P09527 (Rab-7), O88960 (N-ethylmaleimide sensitive), P09456 (PKA I regulatory subunit), P27881 (Hexokinase type II), P07872 (Acyl-coenzyme A oxidase), Q6DGF1 (Isocitrate dehydrogenase), Q9EQX9 (Ubiquitin-conjugating), Q63446 (Polyubiquitin), P24268 (Cathepsin D), Q91XW0 (Heat shock protein 86), Q5FVH0 (unknown), P58405 (Striatin 3), Q62667 (Major vault protein), Q66H50 (unknown), Q09167 (splicing factor), Q9JHU5 (Arfaptin 1)."|comment:"Insulin increased GLUT4 interaction with the following proteins:Q9Z1P2 (R-actinin-1), P45592 (Cofilin), Q9QXQ0 (R-actinin-4), P26473 (ADP-ribosylation factor), P26437 (ADP-ribosylation factor),   Q7TNP1 (Basigin 2), Q6P6R2 (Dihydrolipoamide dehydrogenase),   P04797 (GAPDH), Q63081 (Protein disulfide isomerase), P29457 (47 kDa heat shock protein), Q9R1J8 (Leprecan), O88638 (Putative eps protein),   Q64375 (Synaptonemal complex)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:NDPK - Interactions involving proteins containing InterPro domain IPR001564, Nucleoside diphosphate kinase, core.	taxid:10116(rat-l6)|taxid:10116(Rattus norvegicus)	-	2006/02/15	2021/11/30	rogid:PbFY2lfrty8yw40Jq7ShR7xfuV410116	rogid:3dZJTxWRXQ/VVESnW4wMNvqCNg810116	intact-crc:44F3A2176D02515F|rigid:9RVm0UBcqQF4k06RGKO89Bg16Q8	false	myc tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P19357	uniprotkb:Q9JHU5	intact:EBI-915426|uniprotkb:P97900|ensembl:ENSRNOP00000023256	intact:EBI-919925|ensembl:ENSRNOP00000014236	psi-mi:glut4_rat(display_long)|uniprotkb:Glucose transporter type 4, insulin-responsive(gene name synonym)|uniprotkb:Slc2a4(gene name)|psi-mi:Slc2a4(display_short)|uniprotkb:Glut4(gene name synonym)	psi-mi:arfp1_rat(display_long)|uniprotkb:Arfip1(gene name)|psi-mi:Arfip1(display_short)|uniprotkb:ADP-ribosylation factor-interacting protein 1(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Foster et al. (2006)	pubmed:16396496|mint:MINT-5218203	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-921030	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2711|refseq:NP_036883.1|refseq:XP_006246658.1|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007611"(learning or memory)|go:"GO:0007614"(short-term memory)|go:"GO:0007616"(long-term memory)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010021"(amylopectin biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031550"(positive regulation of brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044381"(glucose import in response to insulin stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046323"(glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0098694"(regulation of synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0098793"(presynapse)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002441("Glucose transporter, type 4 (GLUT4)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-189200|ensembl:ENSRNOG00000017226(gene)|ensembl:ENSRNOT00000023256(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)	rgd:708401|refseq:NP_068531.1|ensembl:ENSRNOG00000010533(gene)|ensembl:ENSRNOT00000014236(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005829"(cytosol)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0032588"(trans-Golgi network membrane)|go:"GO:0034315"(regulation of Arp2/3 complex-mediated actin nucleation)|go:"GO:0050708"(regulation of protein secretion)|go:"GO:0070273"(phosphatidylinositol-4-phosphate binding)|go:"GO:1905280"(negative regulation of retrograde transport, endosome to Golgi)|interpro:IPR010504(Arfaptin-like)|interpro:IPR027267|interpro:IPR030793|interpro:IPR030798	-	-	-	caution:"The participant EBI-349571(P68370) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919386(Q7TP47) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920972(Q5XIP9) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-916419(P11980) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919578(Q8R491) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920554(Q5U3Z7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920647(Q5U2X8) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920585(Q7TP24) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-779677(P05426) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-915744(P02454) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|agonist:Insulin was shown to increase or decrease GLUT4 protein interactions in specific cases.|comment:"Insulin decreased GLUT4 interactions with the following proteins: Q9ER30 (Sarcosin), P09527 (Rab-7), O88960 (N-ethylmaleimide sensitive), P09456 (PKA I regulatory subunit), P27881 (Hexokinase type II), P07872 (Acyl-coenzyme A oxidase), Q6DGF1 (Isocitrate dehydrogenase), Q9EQX9 (Ubiquitin-conjugating), Q63446 (Polyubiquitin), P24268 (Cathepsin D), Q91XW0 (Heat shock protein 86), Q5FVH0 (unknown), P58405 (Striatin 3), Q62667 (Major vault protein), Q66H50 (unknown), Q09167 (splicing factor), Q9JHU5 (Arfaptin 1)."|comment:"Insulin increased GLUT4 interaction with the following proteins:Q9Z1P2 (R-actinin-1), P45592 (Cofilin), Q9QXQ0 (R-actinin-4), P26473 (ADP-ribosylation factor), P26437 (ADP-ribosylation factor),   Q7TNP1 (Basigin 2), Q6P6R2 (Dihydrolipoamide dehydrogenase),   P04797 (GAPDH), Q63081 (Protein disulfide isomerase), P29457 (47 kDa heat shock protein), Q9R1J8 (Leprecan), O88638 (Putative eps protein),   Q64375 (Synaptonemal complex)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:NDPK - Interactions involving proteins containing InterPro domain IPR001564, Nucleoside diphosphate kinase, core.	taxid:10116(rat-l6)|taxid:10116(Rattus norvegicus)	-	2006/02/15	2021/11/30	rogid:PbFY2lfrty8yw40Jq7ShR7xfuV410116	rogid:L2J6/wAT4fhIgB9tJFciQXmf42I10116	intact-crc:44F3A2176D02515F|rigid:9RVm0UBcqQF4k06RGKO89Bg16Q8	false	myc tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P19357	uniprotkb:Q9JHB5	intact:EBI-915426|uniprotkb:P97900|ensembl:ENSRNOP00000023256	intact:EBI-919917|ensembl:ENSRNOP00000063911	psi-mi:glut4_rat(display_long)|uniprotkb:Glucose transporter type 4, insulin-responsive(gene name synonym)|uniprotkb:Slc2a4(gene name)|psi-mi:Slc2a4(display_short)|uniprotkb:Glut4(gene name synonym)	psi-mi:tsnax_rat(display_long)|uniprotkb:Tsnax(gene name)|psi-mi:Tsnax(display_short)|uniprotkb:Trax(gene name synonym)|uniprotkb:Translin-associated factor X(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Foster et al. (2006)	pubmed:16396496|mint:MINT-5218203	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-921030	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2711|refseq:NP_036883.1|refseq:XP_006246658.1|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007611"(learning or memory)|go:"GO:0007614"(short-term memory)|go:"GO:0007616"(long-term memory)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010021"(amylopectin biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031550"(positive regulation of brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044381"(glucose import in response to insulin stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046323"(glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0098694"(regulation of synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0098793"(presynapse)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002441("Glucose transporter, type 4 (GLUT4)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-189200|ensembl:ENSRNOG00000017226(gene)|ensembl:ENSRNOT00000023256(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)	rgd:621574|refseq:NP_071598.1|ensembl:ENSRNOG00000049784(gene)|ensembl:ENSRNOT00000071827(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0004521"(endoribonuclease activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0030154"(cell differentiation)|go:"GO:0031687"(A2A adenosine receptor binding)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|interpro:IPR002848(Translin)|interpro:IPR016068(Translin, N-terminal)|interpro:IPR016069(Translin, C-terminal)|interpro:IPR036081|reactome:R-RNO-426486	-	-	-	caution:"The participant EBI-349571(P68370) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919386(Q7TP47) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920972(Q5XIP9) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-916419(P11980) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919578(Q8R491) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920554(Q5U3Z7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920647(Q5U2X8) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920585(Q7TP24) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-779677(P05426) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-915744(P02454) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|agonist:Insulin was shown to increase or decrease GLUT4 protein interactions in specific cases.|comment:"Insulin decreased GLUT4 interactions with the following proteins: Q9ER30 (Sarcosin), P09527 (Rab-7), O88960 (N-ethylmaleimide sensitive), P09456 (PKA I regulatory subunit), P27881 (Hexokinase type II), P07872 (Acyl-coenzyme A oxidase), Q6DGF1 (Isocitrate dehydrogenase), Q9EQX9 (Ubiquitin-conjugating), Q63446 (Polyubiquitin), P24268 (Cathepsin D), Q91XW0 (Heat shock protein 86), Q5FVH0 (unknown), P58405 (Striatin 3), Q62667 (Major vault protein), Q66H50 (unknown), Q09167 (splicing factor), Q9JHU5 (Arfaptin 1)."|comment:"Insulin increased GLUT4 interaction with the following proteins:Q9Z1P2 (R-actinin-1), P45592 (Cofilin), Q9QXQ0 (R-actinin-4), P26473 (ADP-ribosylation factor), P26437 (ADP-ribosylation factor),   Q7TNP1 (Basigin 2), Q6P6R2 (Dihydrolipoamide dehydrogenase),   P04797 (GAPDH), Q63081 (Protein disulfide isomerase), P29457 (47 kDa heat shock protein), Q9R1J8 (Leprecan), O88638 (Putative eps protein),   Q64375 (Synaptonemal complex)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:NDPK - Interactions involving proteins containing InterPro domain IPR001564, Nucleoside diphosphate kinase, core.	taxid:10116(rat-l6)|taxid:10116(Rattus norvegicus)	-	2006/02/15	2021/11/30	rogid:PbFY2lfrty8yw40Jq7ShR7xfuV410116	rogid:wWY+KvJPMhrQ1kXPbSQgi1FLKhc10116	intact-crc:44F3A2176D02515F|rigid:9RVm0UBcqQF4k06RGKO89Bg16Q8	false	myc tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P19357	uniprotkb:Q9HB97	intact:EBI-915426|uniprotkb:P97900|ensembl:ENSRNOP00000023256	intact:EBI-919909	psi-mi:glut4_rat(display_long)|uniprotkb:Glucose transporter type 4, insulin-responsive(gene name synonym)|uniprotkb:Slc2a4(gene name)|psi-mi:Slc2a4(display_short)|uniprotkb:Glut4(gene name synonym)	psi-mi:parva_rat(display_long)|uniprotkb:Parva(gene name)|psi-mi:Parva(display_short)|uniprotkb:Actp(gene name synonym)|uniprotkb:Actopaxin(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Foster et al. (2006)	pubmed:16396496|mint:MINT-5218203	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-921030	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2711|refseq:NP_036883.1|refseq:XP_006246658.1|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007611"(learning or memory)|go:"GO:0007614"(short-term memory)|go:"GO:0007616"(long-term memory)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010021"(amylopectin biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031550"(positive regulation of brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044381"(glucose import in response to insulin stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046323"(glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0098694"(regulation of synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0098793"(presynapse)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002441("Glucose transporter, type 4 (GLUT4)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-189200|ensembl:ENSRNOG00000017226(gene)|ensembl:ENSRNOT00000023256(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)	interpro:IPR028433|rgd:71021|refseq:NP_065707.2|interpro:IPR001715(Calponin-like actin-binding)|interpro:IPR036872|reactome:R-RNO-446343|reactome:R-RNO-446353|reactome:R-RNO-446388|go:"GO:0002040"(sprouting angiogenesis)|go:"GO:0003148"(outflow tract septum morphogenesis)|go:"GO:0003779"(actin binding)|go:"GO:0004860"(protein kinase inhibitor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0007155"(cell adhesion)|go:"GO:0007163"(establishment or maintenance of cell polarity)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030018"(Z disc)|go:"GO:0030027"(lamellipodium)|go:"GO:0030031"(cell projection assembly)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0034446"(substrate adhesion-dependent cell spreading)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0060271"(cilium assembly)|go:"GO:0070252"(actin-mediated cell contraction)|go:"GO:0071670"(smooth muscle cell chemotaxis)	-	-	-	caution:"The participant EBI-349571(P68370) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919386(Q7TP47) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920972(Q5XIP9) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-916419(P11980) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919578(Q8R491) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920554(Q5U3Z7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920647(Q5U2X8) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920585(Q7TP24) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-779677(P05426) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-915744(P02454) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|agonist:Insulin was shown to increase or decrease GLUT4 protein interactions in specific cases.|comment:"Insulin decreased GLUT4 interactions with the following proteins: Q9ER30 (Sarcosin), P09527 (Rab-7), O88960 (N-ethylmaleimide sensitive), P09456 (PKA I regulatory subunit), P27881 (Hexokinase type II), P07872 (Acyl-coenzyme A oxidase), Q6DGF1 (Isocitrate dehydrogenase), Q9EQX9 (Ubiquitin-conjugating), Q63446 (Polyubiquitin), P24268 (Cathepsin D), Q91XW0 (Heat shock protein 86), Q5FVH0 (unknown), P58405 (Striatin 3), Q62667 (Major vault protein), Q66H50 (unknown), Q09167 (splicing factor), Q9JHU5 (Arfaptin 1)."|comment:"Insulin increased GLUT4 interaction with the following proteins:Q9Z1P2 (R-actinin-1), P45592 (Cofilin), Q9QXQ0 (R-actinin-4), P26473 (ADP-ribosylation factor), P26437 (ADP-ribosylation factor),   Q7TNP1 (Basigin 2), Q6P6R2 (Dihydrolipoamide dehydrogenase),   P04797 (GAPDH), Q63081 (Protein disulfide isomerase), P29457 (47 kDa heat shock protein), Q9R1J8 (Leprecan), O88638 (Putative eps protein),   Q64375 (Synaptonemal complex)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:NDPK - Interactions involving proteins containing InterPro domain IPR001564, Nucleoside diphosphate kinase, core.	taxid:10116(rat-l6)|taxid:10116(Rattus norvegicus)	-	2006/02/15	2021/11/30	rogid:PbFY2lfrty8yw40Jq7ShR7xfuV410116	rogid:1netKay8GZudBsYxvw4Ui49FNnA10116	intact-crc:44F3A2176D02515F|rigid:9RVm0UBcqQF4k06RGKO89Bg16Q8	false	myc tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P19357	uniprotkb:Q9ES40	intact:EBI-915426|uniprotkb:P97900|ensembl:ENSRNOP00000023256	intact:EBI-919899|uniprotkb:Q9JKD1	psi-mi:glut4_rat(display_long)|uniprotkb:Glucose transporter type 4, insulin-responsive(gene name synonym)|uniprotkb:Slc2a4(gene name)|psi-mi:Slc2a4(display_short)|uniprotkb:Glut4(gene name synonym)	psi-mi:praf3_rat(display_long)|uniprotkb:Arl6ip5(gene name)|psi-mi:Arl6ip5(display_short)|uniprotkb:Gtrap3-18(gene name synonym)|uniprotkb:Jwa(gene name synonym)|uniprotkb:Pra2(gene name synonym)|uniprotkb:Praf3(gene name synonym)|uniprotkb:ADP-ribosylation factor-like protein 6-interacting protein 5(gene name synonym)|uniprotkb:Glutamate transporter EAAC1-interacting protein(gene name synonym)|uniprotkb:GTRAP3-18(gene name synonym)|uniprotkb:Prenylated Rab acceptor protein 2(gene name synonym)|uniprotkb:Protein JWa(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Foster et al. (2006)	pubmed:16396496|mint:MINT-5218203	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-921030	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2711|refseq:NP_036883.1|refseq:XP_006246658.1|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007611"(learning or memory)|go:"GO:0007614"(short-term memory)|go:"GO:0007616"(long-term memory)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010021"(amylopectin biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031550"(positive regulation of brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044381"(glucose import in response to insulin stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046323"(glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0098694"(regulation of synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0098793"(presynapse)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002441("Glucose transporter, type 4 (GLUT4)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-189200|ensembl:ENSRNOG00000017226(gene)|ensembl:ENSRNOT00000023256(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)	rgd:708572|refseq:NP_076462.1|interpro:IPR004895(Prenylated rab acceptor PRA1)|reactome:R-RNO-210500|go:"GO:0002037"(negative regulation of L-glutamate import across plasma membrane)|go:"GO:0005737"(cytoplasm)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0006749"(glutathione metabolic process)|go:"GO:0007611"(learning or memory)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008631"(intrinsic apoptotic signaling pathway in response to oxidative stress)|go:"GO:0010917"(negative regulation of mitochondrial membrane potential)|go:"GO:0015031"(protein transport)|go:"GO:0015813"(L-glutamate transmembrane transport)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0032874"(positive regulation of stress-activated MAPK cascade)|go:"GO:0036475"(neuron death in response to oxidative stress)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0051051"(negative regulation of transport)|go:"GO:0051580"(regulation of neurotransmitter uptake)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0098712"(L-glutamate import across plasma membrane)	-	-	-	caution:"The participant EBI-349571(P68370) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919386(Q7TP47) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920972(Q5XIP9) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-916419(P11980) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919578(Q8R491) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920554(Q5U3Z7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920647(Q5U2X8) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920585(Q7TP24) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-779677(P05426) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-915744(P02454) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|agonist:Insulin was shown to increase or decrease GLUT4 protein interactions in specific cases.|comment:"Insulin decreased GLUT4 interactions with the following proteins: Q9ER30 (Sarcosin), P09527 (Rab-7), O88960 (N-ethylmaleimide sensitive), P09456 (PKA I regulatory subunit), P27881 (Hexokinase type II), P07872 (Acyl-coenzyme A oxidase), Q6DGF1 (Isocitrate dehydrogenase), Q9EQX9 (Ubiquitin-conjugating), Q63446 (Polyubiquitin), P24268 (Cathepsin D), Q91XW0 (Heat shock protein 86), Q5FVH0 (unknown), P58405 (Striatin 3), Q62667 (Major vault protein), Q66H50 (unknown), Q09167 (splicing factor), Q9JHU5 (Arfaptin 1)."|comment:"Insulin increased GLUT4 interaction with the following proteins:Q9Z1P2 (R-actinin-1), P45592 (Cofilin), Q9QXQ0 (R-actinin-4), P26473 (ADP-ribosylation factor), P26437 (ADP-ribosylation factor),   Q7TNP1 (Basigin 2), Q6P6R2 (Dihydrolipoamide dehydrogenase),   P04797 (GAPDH), Q63081 (Protein disulfide isomerase), P29457 (47 kDa heat shock protein), Q9R1J8 (Leprecan), O88638 (Putative eps protein),   Q64375 (Synaptonemal complex)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:NDPK - Interactions involving proteins containing InterPro domain IPR001564, Nucleoside diphosphate kinase, core.	taxid:10116(rat-l6)|taxid:10116(Rattus norvegicus)	-	2006/02/15	2021/11/30	rogid:PbFY2lfrty8yw40Jq7ShR7xfuV410116	rogid:9sbB5pbvY2ARf4Ayyv4KmkvRq/c10116	intact-crc:44F3A2176D02515F|rigid:9RVm0UBcqQF4k06RGKO89Bg16Q8	false	myc tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P19357	uniprotkb:Q9ERR2	intact:EBI-915426|uniprotkb:P97900|ensembl:ENSRNOP00000023256	intact:EBI-919894	psi-mi:glut4_rat(display_long)|uniprotkb:Glucose transporter type 4, insulin-responsive(gene name synonym)|uniprotkb:Slc2a4(gene name)|psi-mi:Slc2a4(display_short)|uniprotkb:Glut4(gene name synonym)	psi-mi:comd5_rat(display_long)|uniprotkb:Commd5(gene name)|psi-mi:Commd5(display_short)|uniprotkb:Hypertension-related calcium-regulated gene protein(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Foster et al. (2006)	pubmed:16396496|mint:MINT-5218203	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-921030	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2711|refseq:NP_036883.1|refseq:XP_006246658.1|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007611"(learning or memory)|go:"GO:0007614"(short-term memory)|go:"GO:0007616"(long-term memory)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010021"(amylopectin biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031550"(positive regulation of brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044381"(glucose import in response to insulin stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046323"(glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0098694"(regulation of synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0098793"(presynapse)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002441("Glucose transporter, type 4 (GLUT4)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-189200|ensembl:ENSRNOG00000017226(gene)|ensembl:ENSRNOT00000023256(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)	interpro:IPR017920|rgd:621468|refseq:NP_620808.1|interpro:IPR037357|reactome:R-RNO-8951664|go:"GO:0005634"(nucleus)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0030858"(positive regulation of epithelial cell differentiation)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0072158"(proximal tubule morphogenesis)	-	-	-	caution:"The participant EBI-349571(P68370) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919386(Q7TP47) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920972(Q5XIP9) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-916419(P11980) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919578(Q8R491) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920554(Q5U3Z7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920647(Q5U2X8) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920585(Q7TP24) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-779677(P05426) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-915744(P02454) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|agonist:Insulin was shown to increase or decrease GLUT4 protein interactions in specific cases.|comment:"Insulin decreased GLUT4 interactions with the following proteins: Q9ER30 (Sarcosin), P09527 (Rab-7), O88960 (N-ethylmaleimide sensitive), P09456 (PKA I regulatory subunit), P27881 (Hexokinase type II), P07872 (Acyl-coenzyme A oxidase), Q6DGF1 (Isocitrate dehydrogenase), Q9EQX9 (Ubiquitin-conjugating), Q63446 (Polyubiquitin), P24268 (Cathepsin D), Q91XW0 (Heat shock protein 86), Q5FVH0 (unknown), P58405 (Striatin 3), Q62667 (Major vault protein), Q66H50 (unknown), Q09167 (splicing factor), Q9JHU5 (Arfaptin 1)."|comment:"Insulin increased GLUT4 interaction with the following proteins:Q9Z1P2 (R-actinin-1), P45592 (Cofilin), Q9QXQ0 (R-actinin-4), P26473 (ADP-ribosylation factor), P26437 (ADP-ribosylation factor),   Q7TNP1 (Basigin 2), Q6P6R2 (Dihydrolipoamide dehydrogenase),   P04797 (GAPDH), Q63081 (Protein disulfide isomerase), P29457 (47 kDa heat shock protein), Q9R1J8 (Leprecan), O88638 (Putative eps protein),   Q64375 (Synaptonemal complex)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:NDPK - Interactions involving proteins containing InterPro domain IPR001564, Nucleoside diphosphate kinase, core.	taxid:10116(rat-l6)|taxid:10116(Rattus norvegicus)	-	2006/02/15	2021/11/30	rogid:PbFY2lfrty8yw40Jq7ShR7xfuV410116	rogid:lAzkMXoM7H6Q9bj2gLZtFIiVql410116	intact-crc:44F3A2176D02515F|rigid:9RVm0UBcqQF4k06RGKO89Bg16Q8	false	myc tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P19357	uniprotkb:Q9ERM8	intact:EBI-915426|uniprotkb:P97900|ensembl:ENSRNOP00000023256	intact:EBI-919887	psi-mi:glut4_rat(display_long)|uniprotkb:Glucose transporter type 4, insulin-responsive(gene name synonym)|uniprotkb:Slc2a4(gene name)|psi-mi:Slc2a4(display_short)|uniprotkb:Glut4(gene name synonym)	psi-mi:q9erm8_rat(display_long)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Foster et al. (2006)	pubmed:16396496|mint:MINT-5218203	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-921030	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2711|refseq:NP_036883.1|refseq:XP_006246658.1|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007611"(learning or memory)|go:"GO:0007614"(short-term memory)|go:"GO:0007616"(long-term memory)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010021"(amylopectin biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031550"(positive regulation of brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044381"(glucose import in response to insulin stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046323"(glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0098694"(regulation of synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0098793"(presynapse)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002441("Glucose transporter, type 4 (GLUT4)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-189200|ensembl:ENSRNOG00000017226(gene)|ensembl:ENSRNOT00000023256(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)	interpro:IPR007273(SCAMP)|go:"GO:0015031"(protein transport)|go:"GO:0016021"(integral component of membrane)	-	-	-	caution:"The participant EBI-349571(P68370) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919386(Q7TP47) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920972(Q5XIP9) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-916419(P11980) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919578(Q8R491) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920554(Q5U3Z7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920647(Q5U2X8) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920585(Q7TP24) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-779677(P05426) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-915744(P02454) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|agonist:Insulin was shown to increase or decrease GLUT4 protein interactions in specific cases.|comment:"Insulin decreased GLUT4 interactions with the following proteins: Q9ER30 (Sarcosin), P09527 (Rab-7), O88960 (N-ethylmaleimide sensitive), P09456 (PKA I regulatory subunit), P27881 (Hexokinase type II), P07872 (Acyl-coenzyme A oxidase), Q6DGF1 (Isocitrate dehydrogenase), Q9EQX9 (Ubiquitin-conjugating), Q63446 (Polyubiquitin), P24268 (Cathepsin D), Q91XW0 (Heat shock protein 86), Q5FVH0 (unknown), P58405 (Striatin 3), Q62667 (Major vault protein), Q66H50 (unknown), Q09167 (splicing factor), Q9JHU5 (Arfaptin 1)."|comment:"Insulin increased GLUT4 interaction with the following proteins:Q9Z1P2 (R-actinin-1), P45592 (Cofilin), Q9QXQ0 (R-actinin-4), P26473 (ADP-ribosylation factor), P26437 (ADP-ribosylation factor),   Q7TNP1 (Basigin 2), Q6P6R2 (Dihydrolipoamide dehydrogenase),   P04797 (GAPDH), Q63081 (Protein disulfide isomerase), P29457 (47 kDa heat shock protein), Q9R1J8 (Leprecan), O88638 (Putative eps protein),   Q64375 (Synaptonemal complex)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:NDPK - Interactions involving proteins containing InterPro domain IPR001564, Nucleoside diphosphate kinase, core.	taxid:10116(rat-l6)|taxid:10116(Rattus norvegicus)	-	2006/02/15	2021/11/30	rogid:PbFY2lfrty8yw40Jq7ShR7xfuV410116	rogid:84WyhkC7cCvHaTDaJQIzHAkJ2s010116	intact-crc:44F3A2176D02515F|rigid:9RVm0UBcqQF4k06RGKO89Bg16Q8	false	myc tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P19357	uniprotkb:Q9ERF9	intact:EBI-915426|uniprotkb:P97900|ensembl:ENSRNOP00000023256	intact:EBI-919880	psi-mi:glut4_rat(display_long)|uniprotkb:Glucose transporter type 4, insulin-responsive(gene name synonym)|uniprotkb:Slc2a4(gene name)|psi-mi:Slc2a4(display_short)|uniprotkb:Glut4(gene name synonym)	psi-mi:q9erf9_rat(display_long)|uniprotkb:Arp3(gene name)|psi-mi:Arp3(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Foster et al. (2006)	pubmed:16396496|mint:MINT-5218203	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-921030	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2711|refseq:NP_036883.1|refseq:XP_006246658.1|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007611"(learning or memory)|go:"GO:0007614"(short-term memory)|go:"GO:0007616"(long-term memory)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010021"(amylopectin biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031550"(positive regulation of brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044381"(glucose import in response to insulin stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046323"(glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0098694"(regulation of synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0098793"(presynapse)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002441("Glucose transporter, type 4 (GLUT4)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-189200|ensembl:ENSRNOG00000017226(gene)|ensembl:ENSRNOT00000023256(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)	interpro:IPR004000(Actin/actin-like)|interpro:IPR043129	-	-	-	caution:"The participant EBI-349571(P68370) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919386(Q7TP47) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920972(Q5XIP9) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-916419(P11980) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919578(Q8R491) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920554(Q5U3Z7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920647(Q5U2X8) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920585(Q7TP24) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-779677(P05426) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-915744(P02454) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|agonist:Insulin was shown to increase or decrease GLUT4 protein interactions in specific cases.|comment:"Insulin decreased GLUT4 interactions with the following proteins: Q9ER30 (Sarcosin), P09527 (Rab-7), O88960 (N-ethylmaleimide sensitive), P09456 (PKA I regulatory subunit), P27881 (Hexokinase type II), P07872 (Acyl-coenzyme A oxidase), Q6DGF1 (Isocitrate dehydrogenase), Q9EQX9 (Ubiquitin-conjugating), Q63446 (Polyubiquitin), P24268 (Cathepsin D), Q91XW0 (Heat shock protein 86), Q5FVH0 (unknown), P58405 (Striatin 3), Q62667 (Major vault protein), Q66H50 (unknown), Q09167 (splicing factor), Q9JHU5 (Arfaptin 1)."|comment:"Insulin increased GLUT4 interaction with the following proteins:Q9Z1P2 (R-actinin-1), P45592 (Cofilin), Q9QXQ0 (R-actinin-4), P26473 (ADP-ribosylation factor), P26437 (ADP-ribosylation factor),   Q7TNP1 (Basigin 2), Q6P6R2 (Dihydrolipoamide dehydrogenase),   P04797 (GAPDH), Q63081 (Protein disulfide isomerase), P29457 (47 kDa heat shock protein), Q9R1J8 (Leprecan), O88638 (Putative eps protein),   Q64375 (Synaptonemal complex)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:NDPK - Interactions involving proteins containing InterPro domain IPR001564, Nucleoside diphosphate kinase, core.	taxid:10116(rat-l6)|taxid:10116(Rattus norvegicus)	-	2006/02/15	2021/11/30	rogid:PbFY2lfrty8yw40Jq7ShR7xfuV410116	rogid:IcgKd/FqxhRddGT+5Rsde6PxJ9410116	intact-crc:44F3A2176D02515F|rigid:9RVm0UBcqQF4k06RGKO89Bg16Q8	false	myc tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P19357	uniprotkb:Q9ER30	intact:EBI-915426|uniprotkb:P97900|ensembl:ENSRNOP00000023256	intact:EBI-919869|ensembl:ENSRNOP00000009969	psi-mi:glut4_rat(display_long)|uniprotkb:Glucose transporter type 4, insulin-responsive(gene name synonym)|uniprotkb:Slc2a4(gene name)|psi-mi:Slc2a4(display_short)|uniprotkb:Glut4(gene name synonym)	psi-mi:klh41_rat(display_long)|uniprotkb:Klhl41(gene name)|psi-mi:Klhl41(display_short)|uniprotkb:Kbtbd10(gene name synonym)|uniprotkb:Kel-like protein 23(gene name synonym)|uniprotkb:Kelch repeat and BTB domain-containing protein 10(gene name synonym)|uniprotkb:Kelch-related protein 1(gene name synonym)|uniprotkb:Krp1(gene name synonym)|uniprotkb:Sarcosin(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Foster et al. (2006)	pubmed:16396496|mint:MINT-5218203	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-921030	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2711|refseq:NP_036883.1|refseq:XP_006246658.1|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007611"(learning or memory)|go:"GO:0007614"(short-term memory)|go:"GO:0007616"(long-term memory)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010021"(amylopectin biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031550"(positive regulation of brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044381"(glucose import in response to insulin stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046323"(glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0098694"(regulation of synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0098793"(presynapse)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002441("Glucose transporter, type 4 (GLUT4)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-189200|ensembl:ENSRNOG00000017226(gene)|ensembl:ENSRNOT00000023256(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)	rgd:620852|refseq:NP_476539.1|ensembl:ENSRNOG00000007461(gene)|ensembl:ENSRNOT00000009969(transcript)|go:"GO:0001726"(ruffle)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0030239"(myofibril assembly)|go:"GO:0031143"(pseudopodium)|go:"GO:0031275"(obsolete regulation of lateral pseudopodium assembly)|go:"GO:0031430"(M band)|go:"GO:0031463"(Cul3-RING ubiquitin ligase complex)|go:"GO:0033017"(sarcoplasmic reticulum membrane)|go:"GO:0035914"(skeletal muscle cell differentiation)|go:"GO:0045214"(sarcomere organization)|go:"GO:0045661"(regulation of myoblast differentiation)|go:"GO:0048741"(skeletal muscle fiber development)|go:"GO:2000291"(regulation of myoblast proliferation)|go:"GO:2001014"(regulation of skeletal muscle cell differentiation)|interpro:IPR000210(BTB/POZ-like)|interpro:IPR006652(Kelch repeat type 1)|interpro:IPR011333(BTB/POZ fold)|interpro:IPR011705(BTB/Kelch-associated)|interpro:IPR015915(Kelch-type beta propeller)|interpro:IPR017096(Kelch-like protein, gigaxonin)|interpro:IPR030571|rcsb pdb:2WOZ|reactome:R-RNO-8951664|reactome:R-RNO-983168	-	-	-	caution:"The participant EBI-349571(P68370) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919386(Q7TP47) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920972(Q5XIP9) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-916419(P11980) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919578(Q8R491) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920554(Q5U3Z7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920647(Q5U2X8) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920585(Q7TP24) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-779677(P05426) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-915744(P02454) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|agonist:Insulin was shown to increase or decrease GLUT4 protein interactions in specific cases.|comment:"Insulin decreased GLUT4 interactions with the following proteins: Q9ER30 (Sarcosin), P09527 (Rab-7), O88960 (N-ethylmaleimide sensitive), P09456 (PKA I regulatory subunit), P27881 (Hexokinase type II), P07872 (Acyl-coenzyme A oxidase), Q6DGF1 (Isocitrate dehydrogenase), Q9EQX9 (Ubiquitin-conjugating), Q63446 (Polyubiquitin), P24268 (Cathepsin D), Q91XW0 (Heat shock protein 86), Q5FVH0 (unknown), P58405 (Striatin 3), Q62667 (Major vault protein), Q66H50 (unknown), Q09167 (splicing factor), Q9JHU5 (Arfaptin 1)."|comment:"Insulin increased GLUT4 interaction with the following proteins:Q9Z1P2 (R-actinin-1), P45592 (Cofilin), Q9QXQ0 (R-actinin-4), P26473 (ADP-ribosylation factor), P26437 (ADP-ribosylation factor),   Q7TNP1 (Basigin 2), Q6P6R2 (Dihydrolipoamide dehydrogenase),   P04797 (GAPDH), Q63081 (Protein disulfide isomerase), P29457 (47 kDa heat shock protein), Q9R1J8 (Leprecan), O88638 (Putative eps protein),   Q64375 (Synaptonemal complex)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:NDPK - Interactions involving proteins containing InterPro domain IPR001564, Nucleoside diphosphate kinase, core.	taxid:10116(rat-l6)|taxid:10116(Rattus norvegicus)	-	2006/02/15	2021/11/30	rogid:PbFY2lfrty8yw40Jq7ShR7xfuV410116	rogid:hmWCdhdr4LTDXNsF92pxEFe58e410116	intact-crc:44F3A2176D02515F|rigid:9RVm0UBcqQF4k06RGKO89Bg16Q8	false	myc tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P19357	uniprotkb:Q9EQX9	intact:EBI-915426|uniprotkb:P97900|ensembl:ENSRNOP00000023256	intact:EBI-919861|ensembl:ENSRNOP00000071283	psi-mi:glut4_rat(display_long)|uniprotkb:Glucose transporter type 4, insulin-responsive(gene name synonym)|uniprotkb:Slc2a4(gene name)|psi-mi:Slc2a4(display_short)|uniprotkb:Glut4(gene name synonym)	psi-mi:ube2n_rat(display_long)|uniprotkb:Ube2n(gene name)|psi-mi:Ube2n(display_short)|uniprotkb:Ubiquitin-protein ligase N(gene name synonym)|uniprotkb:Ubiquitin carrier protein N(gene name synonym)|uniprotkb:Bendless-like ubiquitin-conjugating enzyme(gene name synonym)|uniprotkb:E2 ubiquitin-conjugating enzyme N(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Foster et al. (2006)	pubmed:16396496|mint:MINT-5218203	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-921030	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2711|refseq:NP_036883.1|refseq:XP_006246658.1|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007611"(learning or memory)|go:"GO:0007614"(short-term memory)|go:"GO:0007616"(long-term memory)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010021"(amylopectin biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031550"(positive regulation of brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044381"(glucose import in response to insulin stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046323"(glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0098694"(regulation of synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0098793"(presynapse)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002441("Glucose transporter, type 4 (GLUT4)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-189200|ensembl:ENSRNOG00000017226(gene)|ensembl:ENSRNOT00000023256(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)	rgd:621096|refseq:NP_446380.1|go:"GO:0006301"(postreplication repair)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016574"(histone ubiquitination)|go:"GO:0031058"(positive regulation of histone modification)|go:"GO:0031372"(UBC13-MMS2 complex)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033182"(regulation of histone ubiquitination)|go:"GO:0035370"(UBC13-UEV1A complex)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0045739"(positive regulation of DNA repair)|go:"GO:0050852"(T cell receptor signaling pathway)|ensembl:ENSRNOG00000058053(gene)|ensembl:ENSRNOT00000089874(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0000729"(DNA double-strand break processing)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051443"(positive regulation of ubiquitin-protein transferase activity)|go:"GO:0061631"(ubiquitin conjugating enzyme activity)|go:"GO:0070534"(protein K63-linked ubiquitination)|interpro:IPR000608(Ubiquitin-conjugating enzyme, E2)|interpro:IPR016135(Ubiquitin-conjugating enzyme/RWD-like)|interpro:IPR023313	-	-	-	caution:"The participant EBI-349571(P68370) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919386(Q7TP47) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920972(Q5XIP9) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-916419(P11980) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919578(Q8R491) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920554(Q5U3Z7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920647(Q5U2X8) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920585(Q7TP24) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-779677(P05426) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-915744(P02454) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|agonist:Insulin was shown to increase or decrease GLUT4 protein interactions in specific cases.|comment:"Insulin decreased GLUT4 interactions with the following proteins: Q9ER30 (Sarcosin), P09527 (Rab-7), O88960 (N-ethylmaleimide sensitive), P09456 (PKA I regulatory subunit), P27881 (Hexokinase type II), P07872 (Acyl-coenzyme A oxidase), Q6DGF1 (Isocitrate dehydrogenase), Q9EQX9 (Ubiquitin-conjugating), Q63446 (Polyubiquitin), P24268 (Cathepsin D), Q91XW0 (Heat shock protein 86), Q5FVH0 (unknown), P58405 (Striatin 3), Q62667 (Major vault protein), Q66H50 (unknown), Q09167 (splicing factor), Q9JHU5 (Arfaptin 1)."|comment:"Insulin increased GLUT4 interaction with the following proteins:Q9Z1P2 (R-actinin-1), P45592 (Cofilin), Q9QXQ0 (R-actinin-4), P26473 (ADP-ribosylation factor), P26437 (ADP-ribosylation factor),   Q7TNP1 (Basigin 2), Q6P6R2 (Dihydrolipoamide dehydrogenase),   P04797 (GAPDH), Q63081 (Protein disulfide isomerase), P29457 (47 kDa heat shock protein), Q9R1J8 (Leprecan), O88638 (Putative eps protein),   Q64375 (Synaptonemal complex)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:NDPK - Interactions involving proteins containing InterPro domain IPR001564, Nucleoside diphosphate kinase, core.	taxid:10116(rat-l6)|taxid:10116(Rattus norvegicus)	-	2006/02/15	2021/11/30	rogid:PbFY2lfrty8yw40Jq7ShR7xfuV410116	rogid:Mp4Qlcpc5efGFlOnsDQjNVlrh/M10116	intact-crc:44F3A2176D02515F|rigid:9RVm0UBcqQF4k06RGKO89Bg16Q8	false	myc tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P19357	uniprotkb:Q9EQV6	intact:EBI-915426|uniprotkb:P97900|ensembl:ENSRNOP00000023256	intact:EBI-919855	psi-mi:glut4_rat(display_long)|uniprotkb:Glucose transporter type 4, insulin-responsive(gene name synonym)|uniprotkb:Slc2a4(gene name)|psi-mi:Slc2a4(display_short)|uniprotkb:Glut4(gene name synonym)	psi-mi:tpp1_rat(display_long)|uniprotkb:Tpp1(gene name)|psi-mi:Tpp1(display_short)|uniprotkb:Cln2(gene name synonym)|uniprotkb:Tripeptidyl-peptidase I(gene name synonym)|uniprotkb:Tripeptidyl aminopeptidase(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Foster et al. (2006)	pubmed:16396496|mint:MINT-5218203	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-921030	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2711|refseq:NP_036883.1|refseq:XP_006246658.1|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007611"(learning or memory)|go:"GO:0007614"(short-term memory)|go:"GO:0007616"(long-term memory)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010021"(amylopectin biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031550"(positive regulation of brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044381"(glucose import in response to insulin stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046323"(glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0098694"(regulation of synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0098793"(presynapse)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002441("Glucose transporter, type 4 (GLUT4)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-189200|ensembl:ENSRNOG00000017226(gene)|ensembl:ENSRNOT00000023256(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)	rgd:621296|refseq:NP_112647.1|interpro:IPR015366(Peptidase S53, propeptide)|interpro:IPR030400|interpro:IPR036852|interpro:IPR000209(Peptidase S8 and S53, subtilisin, kexin, sedolisin)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005764"(lysosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0006508"(proteolysis)|go:"GO:0007040"(lysosome organization)|go:"GO:0007399"(nervous system development)|go:"GO:0007417"(central nervous system development)|go:"GO:0008233"(peptidase activity)|go:"GO:0008236"(serine-type peptidase activity)|go:"GO:0008240"(tripeptidyl-peptidase activity)|go:"GO:0030855"(epithelial cell differentiation)|go:"GO:0035727"(lysophosphatidic acid binding)|go:"GO:0042277"(peptide binding)|go:"GO:0042470"(melanosome)|go:"GO:0043171"(peptide catabolic process)|go:"GO:0045121"(membrane raft)|go:"GO:0045453"(bone resorption)|go:"GO:0046872"(metal ion binding)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0055037"(recycling endosome)|go:"GO:0070198"(protein localization to chromosome, telomeric region)|go:"GO:0120146"(sulfatide binding)|go:"GO:1905146"(lysosomal protein catabolic process)	-	-	-	caution:"The participant EBI-349571(P68370) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919386(Q7TP47) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920972(Q5XIP9) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-916419(P11980) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919578(Q8R491) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920554(Q5U3Z7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920647(Q5U2X8) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920585(Q7TP24) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-779677(P05426) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-915744(P02454) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|agonist:Insulin was shown to increase or decrease GLUT4 protein interactions in specific cases.|comment:"Insulin decreased GLUT4 interactions with the following proteins: Q9ER30 (Sarcosin), P09527 (Rab-7), O88960 (N-ethylmaleimide sensitive), P09456 (PKA I regulatory subunit), P27881 (Hexokinase type II), P07872 (Acyl-coenzyme A oxidase), Q6DGF1 (Isocitrate dehydrogenase), Q9EQX9 (Ubiquitin-conjugating), Q63446 (Polyubiquitin), P24268 (Cathepsin D), Q91XW0 (Heat shock protein 86), Q5FVH0 (unknown), P58405 (Striatin 3), Q62667 (Major vault protein), Q66H50 (unknown), Q09167 (splicing factor), Q9JHU5 (Arfaptin 1)."|comment:"Insulin increased GLUT4 interaction with the following proteins:Q9Z1P2 (R-actinin-1), P45592 (Cofilin), Q9QXQ0 (R-actinin-4), P26473 (ADP-ribosylation factor), P26437 (ADP-ribosylation factor),   Q7TNP1 (Basigin 2), Q6P6R2 (Dihydrolipoamide dehydrogenase),   P04797 (GAPDH), Q63081 (Protein disulfide isomerase), P29457 (47 kDa heat shock protein), Q9R1J8 (Leprecan), O88638 (Putative eps protein),   Q64375 (Synaptonemal complex)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:NDPK - Interactions involving proteins containing InterPro domain IPR001564, Nucleoside diphosphate kinase, core.	taxid:10116(rat-l6)|taxid:10116(Rattus norvegicus)	-	2006/02/15	2021/11/30	rogid:PbFY2lfrty8yw40Jq7ShR7xfuV410116	rogid:BG06mZdEHW906PB0QWpVdKBpeBI10116	intact-crc:44F3A2176D02515F|rigid:9RVm0UBcqQF4k06RGKO89Bg16Q8	false	myc tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P19357	uniprotkb:Q6P7S1	intact:EBI-915426|uniprotkb:P97900|ensembl:ENSRNOP00000023256	intact:EBI-919850|uniprotkb:Q9EQJ6|ensembl:ENSRNOP00000013463	psi-mi:glut4_rat(display_long)|uniprotkb:Glucose transporter type 4, insulin-responsive(gene name synonym)|uniprotkb:Slc2a4(gene name)|psi-mi:Slc2a4(display_short)|uniprotkb:Glut4(gene name synonym)	psi-mi:asah1_rat(display_long)|uniprotkb:Asah1(gene name)|psi-mi:Asah1(display_short)|uniprotkb:Acylsphingosine deacylase(gene name synonym)|uniprotkb:N-acylsphingosine amidohydrolase(gene name synonym)|uniprotkb:N-acylethanolamine hydrolase ASAH1(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Foster et al. (2006)	pubmed:16396496|mint:MINT-5218203	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-921030	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2711|refseq:NP_036883.1|refseq:XP_006246658.1|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007611"(learning or memory)|go:"GO:0007614"(short-term memory)|go:"GO:0007616"(long-term memory)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010021"(amylopectin biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031550"(positive regulation of brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044381"(glucose import in response to insulin stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046323"(glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0098694"(regulation of synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0098793"(presynapse)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002441("Glucose transporter, type 4 (GLUT4)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-189200|ensembl:ENSRNOG00000017226(gene)|ensembl:ENSRNOT00000023256(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)	rgd:621568|refseq:NP_445859.2|ensembl:ENSRNOG00000010034(gene)|ensembl:ENSRNOT00000013463(transcript)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005764"(lysosome)|go:"GO:0006631"(fatty acid metabolic process)|go:"GO:0010033"(response to organic substance)|go:"GO:0016810"("hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds")|go:"GO:0016811"("hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides")|go:"GO:0017040"(N-acylsphingosine amidohydrolase activity)|go:"GO:0017064"(fatty acid amide hydrolase activity)|go:"GO:0030216"(keratinocyte differentiation)|go:"GO:0030324"(lung development)|go:"GO:0046512"(sphingosine biosynthetic process)|go:"GO:0046513"(ceramide biosynthetic process)|go:"GO:0046514"(ceramide catabolic process)|go:"GO:0050810"(regulation of steroid biosynthetic process)|go:"GO:0062098"(regulation of programmed necrotic cell death)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0102121"(ceramidase activity)|interpro:IPR016699(Acid ceramidase-like)|interpro:IPR029130|interpro:IPR029132|reactome:R-RNO-1660662|reactome:R-RNO-6798695	-	-	-	caution:"The participant EBI-349571(P68370) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919386(Q7TP47) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920972(Q5XIP9) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-916419(P11980) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919578(Q8R491) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920554(Q5U3Z7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920647(Q5U2X8) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920585(Q7TP24) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-779677(P05426) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-915744(P02454) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|agonist:Insulin was shown to increase or decrease GLUT4 protein interactions in specific cases.|comment:"Insulin decreased GLUT4 interactions with the following proteins: Q9ER30 (Sarcosin), P09527 (Rab-7), O88960 (N-ethylmaleimide sensitive), P09456 (PKA I regulatory subunit), P27881 (Hexokinase type II), P07872 (Acyl-coenzyme A oxidase), Q6DGF1 (Isocitrate dehydrogenase), Q9EQX9 (Ubiquitin-conjugating), Q63446 (Polyubiquitin), P24268 (Cathepsin D), Q91XW0 (Heat shock protein 86), Q5FVH0 (unknown), P58405 (Striatin 3), Q62667 (Major vault protein), Q66H50 (unknown), Q09167 (splicing factor), Q9JHU5 (Arfaptin 1)."|comment:"Insulin increased GLUT4 interaction with the following proteins:Q9Z1P2 (R-actinin-1), P45592 (Cofilin), Q9QXQ0 (R-actinin-4), P26473 (ADP-ribosylation factor), P26437 (ADP-ribosylation factor),   Q7TNP1 (Basigin 2), Q6P6R2 (Dihydrolipoamide dehydrogenase),   P04797 (GAPDH), Q63081 (Protein disulfide isomerase), P29457 (47 kDa heat shock protein), Q9R1J8 (Leprecan), O88638 (Putative eps protein),   Q64375 (Synaptonemal complex)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:NDPK - Interactions involving proteins containing InterPro domain IPR001564, Nucleoside diphosphate kinase, core.	taxid:10116(rat-l6)|taxid:10116(Rattus norvegicus)	-	2006/02/15	2021/11/30	rogid:PbFY2lfrty8yw40Jq7ShR7xfuV410116	rogid:P7I8EZHrqVDvJBzzLA7MzYBj0hY10116	intact-crc:44F3A2176D02515F|rigid:9RVm0UBcqQF4k06RGKO89Bg16Q8	false	myc tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P19357	uniprotkb:Q9EPV3	intact:EBI-915426|uniprotkb:P97900|ensembl:ENSRNOP00000023256	intact:EBI-919841	psi-mi:glut4_rat(display_long)|uniprotkb:Glucose transporter type 4, insulin-responsive(gene name synonym)|uniprotkb:Slc2a4(gene name)|psi-mi:Slc2a4(display_short)|uniprotkb:Glut4(gene name synonym)	psi-mi:q9epv3_rat(display_long)|uniprotkb:Emap2(gene name)|psi-mi:Emap2(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Foster et al. (2006)	pubmed:16396496|mint:MINT-5218203	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-921030	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2711|refseq:NP_036883.1|refseq:XP_006246658.1|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007611"(learning or memory)|go:"GO:0007614"(short-term memory)|go:"GO:0007616"(long-term memory)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010021"(amylopectin biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031550"(positive regulation of brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044381"(glucose import in response to insulin stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046323"(glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0098694"(regulation of synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0098793"(presynapse)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002441("Glucose transporter, type 4 (GLUT4)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-189200|ensembl:ENSRNOG00000017226(gene)|ensembl:ENSRNOT00000023256(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)	interpro:IPR012340(Nucleic acid-binding, OB-fold)|interpro:IPR002547(tRNA-binding region)|go:"GO:0000049"(tRNA binding)	-	-	-	caution:"The participant EBI-349571(P68370) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919386(Q7TP47) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920972(Q5XIP9) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-916419(P11980) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919578(Q8R491) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920554(Q5U3Z7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920647(Q5U2X8) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920585(Q7TP24) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-779677(P05426) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-915744(P02454) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|agonist:Insulin was shown to increase or decrease GLUT4 protein interactions in specific cases.|comment:"Insulin decreased GLUT4 interactions with the following proteins: Q9ER30 (Sarcosin), P09527 (Rab-7), O88960 (N-ethylmaleimide sensitive), P09456 (PKA I regulatory subunit), P27881 (Hexokinase type II), P07872 (Acyl-coenzyme A oxidase), Q6DGF1 (Isocitrate dehydrogenase), Q9EQX9 (Ubiquitin-conjugating), Q63446 (Polyubiquitin), P24268 (Cathepsin D), Q91XW0 (Heat shock protein 86), Q5FVH0 (unknown), P58405 (Striatin 3), Q62667 (Major vault protein), Q66H50 (unknown), Q09167 (splicing factor), Q9JHU5 (Arfaptin 1)."|comment:"Insulin increased GLUT4 interaction with the following proteins:Q9Z1P2 (R-actinin-1), P45592 (Cofilin), Q9QXQ0 (R-actinin-4), P26473 (ADP-ribosylation factor), P26437 (ADP-ribosylation factor),   Q7TNP1 (Basigin 2), Q6P6R2 (Dihydrolipoamide dehydrogenase),   P04797 (GAPDH), Q63081 (Protein disulfide isomerase), P29457 (47 kDa heat shock protein), Q9R1J8 (Leprecan), O88638 (Putative eps protein),   Q64375 (Synaptonemal complex)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:NDPK - Interactions involving proteins containing InterPro domain IPR001564, Nucleoside diphosphate kinase, core.	taxid:10116(rat-l6)|taxid:10116(Rattus norvegicus)	-	2006/02/15	2021/11/30	rogid:PbFY2lfrty8yw40Jq7ShR7xfuV410116	rogid:g7G+/IHDkuj3HtDNMLjPTr7e8KQ10116	intact-crc:44F3A2176D02515F|rigid:9RVm0UBcqQF4k06RGKO89Bg16Q8	false	myc tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P19357	uniprotkb:Q9EPJ3	intact:EBI-915426|uniprotkb:P97900|ensembl:ENSRNOP00000023256	intact:EBI-919837|ensembl:ENSRNOP00000028828	psi-mi:glut4_rat(display_long)|uniprotkb:Glucose transporter type 4, insulin-responsive(gene name synonym)|uniprotkb:Slc2a4(gene name)|psi-mi:Slc2a4(display_short)|uniprotkb:Glut4(gene name synonym)	psi-mi:rt26_rat(display_long)|uniprotkb:Mrps26(gene name)|psi-mi:Mrps26(display_short)|uniprotkb:Protein 5'OT-EST(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Foster et al. (2006)	pubmed:16396496|mint:MINT-5218203	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-921030	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2711|refseq:NP_036883.1|refseq:XP_006246658.1|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007611"(learning or memory)|go:"GO:0007614"(short-term memory)|go:"GO:0007616"(long-term memory)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010021"(amylopectin biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031550"(positive regulation of brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044381"(glucose import in response to insulin stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046323"(glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0098694"(regulation of synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0098793"(presynapse)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002441("Glucose transporter, type 4 (GLUT4)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-189200|ensembl:ENSRNOG00000017226(gene)|ensembl:ENSRNOT00000023256(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)	rgd:1308733|refseq:NP_001013224.1|ensembl:ENSRNOG00000021224(gene)|ensembl:ENSRNOT00000028828(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005763"(mitochondrial small ribosomal subunit)|interpro:IPR026140|reactome:R-RNO-5389840|reactome:R-RNO-5419276	-	-	-	caution:"The participant EBI-349571(P68370) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919386(Q7TP47) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920972(Q5XIP9) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-916419(P11980) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919578(Q8R491) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920554(Q5U3Z7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920647(Q5U2X8) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920585(Q7TP24) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-779677(P05426) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-915744(P02454) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|agonist:Insulin was shown to increase or decrease GLUT4 protein interactions in specific cases.|comment:"Insulin decreased GLUT4 interactions with the following proteins: Q9ER30 (Sarcosin), P09527 (Rab-7), O88960 (N-ethylmaleimide sensitive), P09456 (PKA I regulatory subunit), P27881 (Hexokinase type II), P07872 (Acyl-coenzyme A oxidase), Q6DGF1 (Isocitrate dehydrogenase), Q9EQX9 (Ubiquitin-conjugating), Q63446 (Polyubiquitin), P24268 (Cathepsin D), Q91XW0 (Heat shock protein 86), Q5FVH0 (unknown), P58405 (Striatin 3), Q62667 (Major vault protein), Q66H50 (unknown), Q09167 (splicing factor), Q9JHU5 (Arfaptin 1)."|comment:"Insulin increased GLUT4 interaction with the following proteins:Q9Z1P2 (R-actinin-1), P45592 (Cofilin), Q9QXQ0 (R-actinin-4), P26473 (ADP-ribosylation factor), P26437 (ADP-ribosylation factor),   Q7TNP1 (Basigin 2), Q6P6R2 (Dihydrolipoamide dehydrogenase),   P04797 (GAPDH), Q63081 (Protein disulfide isomerase), P29457 (47 kDa heat shock protein), Q9R1J8 (Leprecan), O88638 (Putative eps protein),   Q64375 (Synaptonemal complex)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:NDPK - Interactions involving proteins containing InterPro domain IPR001564, Nucleoside diphosphate kinase, core.	taxid:10116(rat-l6)|taxid:10116(Rattus norvegicus)	-	2006/02/15	2021/11/30	rogid:PbFY2lfrty8yw40Jq7ShR7xfuV410116	rogid:HojFpQS4AQlnf0TjeY7Ao3pfGYM10116	intact-crc:44F3A2176D02515F|rigid:9RVm0UBcqQF4k06RGKO89Bg16Q8	false	myc tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P19357	uniprotkb:Q9EPH8	intact:EBI-915426|uniprotkb:P97900|ensembl:ENSRNOP00000023256	intact:EBI-919825|ensembl:ENSRNOP00000012775	psi-mi:glut4_rat(display_long)|uniprotkb:Glucose transporter type 4, insulin-responsive(gene name synonym)|uniprotkb:Slc2a4(gene name)|psi-mi:Slc2a4(display_short)|uniprotkb:Glut4(gene name synonym)	psi-mi:pabp1_rat(display_long)|uniprotkb:Pabpc1(gene name)|psi-mi:Pabpc1(display_short)|uniprotkb:Pabp1(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Foster et al. (2006)	pubmed:16396496|mint:MINT-5218203	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-921030	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2711|refseq:NP_036883.1|refseq:XP_006246658.1|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007611"(learning or memory)|go:"GO:0007614"(short-term memory)|go:"GO:0007616"(long-term memory)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010021"(amylopectin biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031550"(positive regulation of brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044381"(glucose import in response to insulin stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046323"(glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0098694"(regulation of synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0098793"(presynapse)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002441("Glucose transporter, type 4 (GLUT4)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-189200|ensembl:ENSRNOG00000017226(gene)|ensembl:ENSRNOT00000023256(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)	rgd:619838|refseq:NP_599180.1|ensembl:ENSRNOG00000008639(gene)|ensembl:ENSRNOT00000012775(transcript)|go:"GO:0000184"(nuclear-transcribed mRNA catabolic process, nonsense-mediated decay)|go:"GO:0003723"(RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006397"(mRNA processing)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008143"("poly(A) binding")|go:"GO:0008266"("poly(U) RNA binding")|go:"GO:0008380"(RNA splicing)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0030027"(lamellipodium)|go:"GO:0030425"(dendrite)|go:"GO:0031047"(gene silencing by RNA)|go:"GO:0031252"(cell leading edge)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0045070"(positive regulation of viral genome replication)|go:"GO:0045202"(synapse)|go:"GO:0060213"("positive regulation of nuclear-transcribed mRNA poly(A) tail shortening")|go:"GO:0071013"(catalytic step 2 spliceosome)|go:"GO:1900153"(positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay)|go:"GO:1990124"(messenger ribonucleoprotein complex)|go:"GO:1990904"(ribonucleoprotein complex)|go:"GO:2000623"(negative regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR002004(Polyadenylate-binding protein/Hyperplastic disc protein)|interpro:IPR003954(RNA recognition, region 1)|interpro:IPR006515(Polyadenylate binding protein, human types 1, 2, 3, 4)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR035979|interpro:IPR036053|mint:Q9EPH8|reactome:R-RNO-156827|reactome:R-RNO-429947|reactome:R-RNO-450408|reactome:R-RNO-72649|reactome:R-RNO-975956|reactome:R-RNO-975957	-	-	-	caution:"The participant EBI-349571(P68370) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919386(Q7TP47) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920972(Q5XIP9) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-916419(P11980) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919578(Q8R491) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920554(Q5U3Z7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920647(Q5U2X8) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920585(Q7TP24) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-779677(P05426) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-915744(P02454) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|agonist:Insulin was shown to increase or decrease GLUT4 protein interactions in specific cases.|comment:"Insulin decreased GLUT4 interactions with the following proteins: Q9ER30 (Sarcosin), P09527 (Rab-7), O88960 (N-ethylmaleimide sensitive), P09456 (PKA I regulatory subunit), P27881 (Hexokinase type II), P07872 (Acyl-coenzyme A oxidase), Q6DGF1 (Isocitrate dehydrogenase), Q9EQX9 (Ubiquitin-conjugating), Q63446 (Polyubiquitin), P24268 (Cathepsin D), Q91XW0 (Heat shock protein 86), Q5FVH0 (unknown), P58405 (Striatin 3), Q62667 (Major vault protein), Q66H50 (unknown), Q09167 (splicing factor), Q9JHU5 (Arfaptin 1)."|comment:"Insulin increased GLUT4 interaction with the following proteins:Q9Z1P2 (R-actinin-1), P45592 (Cofilin), Q9QXQ0 (R-actinin-4), P26473 (ADP-ribosylation factor), P26437 (ADP-ribosylation factor),   Q7TNP1 (Basigin 2), Q6P6R2 (Dihydrolipoamide dehydrogenase),   P04797 (GAPDH), Q63081 (Protein disulfide isomerase), P29457 (47 kDa heat shock protein), Q9R1J8 (Leprecan), O88638 (Putative eps protein),   Q64375 (Synaptonemal complex)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:NDPK - Interactions involving proteins containing InterPro domain IPR001564, Nucleoside diphosphate kinase, core.	taxid:10116(rat-l6)|taxid:10116(Rattus norvegicus)	-	2006/02/15	2021/11/30	rogid:PbFY2lfrty8yw40Jq7ShR7xfuV410116	rogid:SEu6ZUy3fI2xh8x9pqs+9OCtt+M10116	intact-crc:44F3A2176D02515F|rigid:9RVm0UBcqQF4k06RGKO89Bg16Q8	false	myc tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P19357	uniprotkb:Q9EPC6	intact:EBI-915426|uniprotkb:P97900|ensembl:ENSRNOP00000023256	intact:EBI-919808|uniprotkb:Q9JHU7|ensembl:ENSRNOP00000023469	psi-mi:glut4_rat(display_long)|uniprotkb:Glucose transporter type 4, insulin-responsive(gene name synonym)|uniprotkb:Slc2a4(gene name)|psi-mi:Slc2a4(display_short)|uniprotkb:Glut4(gene name synonym)	psi-mi:prof2_rat(display_long)|uniprotkb:Pfn2(gene name)|psi-mi:Pfn2(display_short)|uniprotkb:Profilin II(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Foster et al. (2006)	pubmed:16396496|mint:MINT-5218203	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-921030	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2711|refseq:NP_036883.1|refseq:XP_006246658.1|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007611"(learning or memory)|go:"GO:0007614"(short-term memory)|go:"GO:0007616"(long-term memory)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010021"(amylopectin biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031550"(positive regulation of brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044381"(glucose import in response to insulin stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046323"(glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0098694"(regulation of synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0098793"(presynapse)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002441("Glucose transporter, type 4 (GLUT4)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-189200|ensembl:ENSRNOG00000017226(gene)|ensembl:ENSRNOT00000023256(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)	rgd:621826|refseq:NP_110500.1|refseq:XP_006232452.1|refseq:XP_003749330.1|ensembl:ENSRNOG00000017427(gene)|ensembl:ENSRNOT00000023469(transcript)|go:"GO:0003779"(actin binding)|go:"GO:0003785"(actin monomer binding)|go:"GO:0005546"(phosphatidylinositol-4,5-bisphosphate binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005856"(cytoskeleton)|go:"GO:0010633"(negative regulation of epithelial cell migration)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030833"(regulation of actin filament polymerization)|go:"GO:0030837"(negative regulation of actin filament polymerization)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0032233"(positive regulation of actin filament bundle assembly)|go:"GO:0032781"(positive regulation of ATP-dependent activity)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0050821"(protein stabilization)|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098793"(presynapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098885"(modification of postsynaptic actin cytoskeleton)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1900028"(negative regulation of ruffle assembly)|go:"GO:2000300"(regulation of synaptic vesicle exocytosis)|interpro:IPR005454(Profilin, Mammalian)|interpro:IPR005455(Profilin, plant)|interpro:IPR027310|interpro:IPR029891|interpro:IPR036140|rcsb pdb:2VK3|reactome:R-RNO-5663220	-	-	-	caution:"The participant EBI-349571(P68370) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919386(Q7TP47) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920972(Q5XIP9) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-916419(P11980) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919578(Q8R491) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920554(Q5U3Z7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920647(Q5U2X8) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920585(Q7TP24) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-779677(P05426) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-915744(P02454) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|agonist:Insulin was shown to increase or decrease GLUT4 protein interactions in specific cases.|comment:"Insulin decreased GLUT4 interactions with the following proteins: Q9ER30 (Sarcosin), P09527 (Rab-7), O88960 (N-ethylmaleimide sensitive), P09456 (PKA I regulatory subunit), P27881 (Hexokinase type II), P07872 (Acyl-coenzyme A oxidase), Q6DGF1 (Isocitrate dehydrogenase), Q9EQX9 (Ubiquitin-conjugating), Q63446 (Polyubiquitin), P24268 (Cathepsin D), Q91XW0 (Heat shock protein 86), Q5FVH0 (unknown), P58405 (Striatin 3), Q62667 (Major vault protein), Q66H50 (unknown), Q09167 (splicing factor), Q9JHU5 (Arfaptin 1)."|comment:"Insulin increased GLUT4 interaction with the following proteins:Q9Z1P2 (R-actinin-1), P45592 (Cofilin), Q9QXQ0 (R-actinin-4), P26473 (ADP-ribosylation factor), P26437 (ADP-ribosylation factor),   Q7TNP1 (Basigin 2), Q6P6R2 (Dihydrolipoamide dehydrogenase),   P04797 (GAPDH), Q63081 (Protein disulfide isomerase), P29457 (47 kDa heat shock protein), Q9R1J8 (Leprecan), O88638 (Putative eps protein),   Q64375 (Synaptonemal complex)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:NDPK - Interactions involving proteins containing InterPro domain IPR001564, Nucleoside diphosphate kinase, core.	taxid:10116(rat-l6)|taxid:10116(Rattus norvegicus)	-	2006/02/15	2021/11/30	rogid:PbFY2lfrty8yw40Jq7ShR7xfuV410116	rogid:PjDYI6rsnySXok6aOEM6oF2/E3U10116	intact-crc:44F3A2176D02515F|rigid:9RVm0UBcqQF4k06RGKO89Bg16Q8	false	myc tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P19357	uniprotkb:Q9EPB1	intact:EBI-915426|uniprotkb:P97900|ensembl:ENSRNOP00000023256	intact:EBI-919793|ensembl:ENSRNOP00000017271	psi-mi:glut4_rat(display_long)|uniprotkb:Glucose transporter type 4, insulin-responsive(gene name synonym)|uniprotkb:Slc2a4(gene name)|psi-mi:Slc2a4(display_short)|uniprotkb:Glut4(gene name synonym)	psi-mi:dpp2_rat(display_long)|uniprotkb:Dpp7(gene name)|psi-mi:Dpp7(display_short)|uniprotkb:Dpp2(gene name synonym)|uniprotkb:Dipeptidyl peptidase II(gene name synonym)|uniprotkb:Dipeptidyl aminopeptidase II(gene name synonym)|uniprotkb:Quiescent cell proline dipeptidase(gene name synonym)|uniprotkb:Dipeptidyl peptidase 7(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Foster et al. (2006)	pubmed:16396496|mint:MINT-5218203	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-921030	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2711|refseq:NP_036883.1|refseq:XP_006246658.1|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007611"(learning or memory)|go:"GO:0007614"(short-term memory)|go:"GO:0007616"(long-term memory)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010021"(amylopectin biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031550"(positive regulation of brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044381"(glucose import in response to insulin stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046323"(glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0098694"(regulation of synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0098793"(presynapse)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002441("Glucose transporter, type 4 (GLUT4)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-189200|ensembl:ENSRNOG00000017226(gene)|ensembl:ENSRNOT00000023256(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)	rgd:71073|refseq:NP_114179.1|ensembl:ENSRNOG00000012640(gene)|ensembl:ENSRNOT00000017271(transcript)|go:"GO:0004177"(aminopeptidase activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005764"(lysosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006508"(proteolysis)|go:"GO:0008236"(serine-type peptidase activity)|go:"GO:0008239"(dipeptidyl-peptidase activity)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031982"(vesicle)|go:"GO:1905146"(lysosomal protein catabolic process)|interpro:IPR008758(Peptidase S28)|interpro:IPR029058|interpro:IPR042269|reactome:R-RNO-6798695	-	-	-	caution:"The participant EBI-349571(P68370) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919386(Q7TP47) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920972(Q5XIP9) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-916419(P11980) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919578(Q8R491) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920554(Q5U3Z7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920647(Q5U2X8) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920585(Q7TP24) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-779677(P05426) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-915744(P02454) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|agonist:Insulin was shown to increase or decrease GLUT4 protein interactions in specific cases.|comment:"Insulin decreased GLUT4 interactions with the following proteins: Q9ER30 (Sarcosin), P09527 (Rab-7), O88960 (N-ethylmaleimide sensitive), P09456 (PKA I regulatory subunit), P27881 (Hexokinase type II), P07872 (Acyl-coenzyme A oxidase), Q6DGF1 (Isocitrate dehydrogenase), Q9EQX9 (Ubiquitin-conjugating), Q63446 (Polyubiquitin), P24268 (Cathepsin D), Q91XW0 (Heat shock protein 86), Q5FVH0 (unknown), P58405 (Striatin 3), Q62667 (Major vault protein), Q66H50 (unknown), Q09167 (splicing factor), Q9JHU5 (Arfaptin 1)."|comment:"Insulin increased GLUT4 interaction with the following proteins:Q9Z1P2 (R-actinin-1), P45592 (Cofilin), Q9QXQ0 (R-actinin-4), P26473 (ADP-ribosylation factor), P26437 (ADP-ribosylation factor),   Q7TNP1 (Basigin 2), Q6P6R2 (Dihydrolipoamide dehydrogenase),   P04797 (GAPDH), Q63081 (Protein disulfide isomerase), P29457 (47 kDa heat shock protein), Q9R1J8 (Leprecan), O88638 (Putative eps protein),   Q64375 (Synaptonemal complex)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:NDPK - Interactions involving proteins containing InterPro domain IPR001564, Nucleoside diphosphate kinase, core.	taxid:10116(rat-l6)|taxid:10116(Rattus norvegicus)	-	2006/02/15	2021/11/30	rogid:PbFY2lfrty8yw40Jq7ShR7xfuV410116	rogid:sIyt7/8/4AMdYSqie4znqMnPtjA10116	intact-crc:44F3A2176D02515F|rigid:9RVm0UBcqQF4k06RGKO89Bg16Q8	false	myc tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P19357	uniprotkb:Q99PW3	intact:EBI-915426|uniprotkb:P97900|ensembl:ENSRNOP00000023256	intact:EBI-919787	psi-mi:glut4_rat(display_long)|uniprotkb:Glucose transporter type 4, insulin-responsive(gene name synonym)|uniprotkb:Slc2a4(gene name)|psi-mi:Slc2a4(display_short)|uniprotkb:Glut4(gene name synonym)	psi-mi:neur1_rat(display_long)|uniprotkb:Neu1(gene name)|psi-mi:Neu1(display_short)|uniprotkb:Lysosomal sialidase(gene name synonym)|uniprotkb:N-acetyl-alpha-neuraminidase 1(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Foster et al. (2006)	pubmed:16396496|mint:MINT-5218203	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-921030	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2711|refseq:NP_036883.1|refseq:XP_006246658.1|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007611"(learning or memory)|go:"GO:0007614"(short-term memory)|go:"GO:0007616"(long-term memory)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010021"(amylopectin biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031550"(positive regulation of brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044381"(glucose import in response to insulin stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046323"(glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0098694"(regulation of synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0098793"(presynapse)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002441("Glucose transporter, type 4 (GLUT4)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-189200|ensembl:ENSRNOG00000017226(gene)|ensembl:ENSRNOT00000023256(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)	interpro:IPR026856|interpro:IPR011040(Neuraminidase)|rgd:3163|interpro:IPR036278|reactome:R-RNO-1660662|reactome:R-RNO-4085001|reactome:R-RNO-6798695|go:"GO:0004308"(exo-alpha-sialidase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0006689"(ganglioside catabolic process)|go:"GO:0009313"(oligosaccharide catabolic process)|go:"GO:0009986"(cell surface)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0016020"(membrane)|go:"GO:0016997"(alpha-sialidase activity)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0043202"(lysosomal lumen)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0052794"("exo-alpha-(2->3)-sialidase activity")|go:"GO:0052795"("exo-alpha-(2->6)-sialidase activity")|go:"GO:0052796"("exo-alpha-(2->8)-sialidase activity")|go:"GO:2000291"(regulation of myoblast proliferation)	-	-	-	caution:"The participant EBI-349571(P68370) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919386(Q7TP47) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920972(Q5XIP9) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-916419(P11980) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919578(Q8R491) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920554(Q5U3Z7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920647(Q5U2X8) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920585(Q7TP24) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-779677(P05426) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-915744(P02454) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|agonist:Insulin was shown to increase or decrease GLUT4 protein interactions in specific cases.|comment:"Insulin decreased GLUT4 interactions with the following proteins: Q9ER30 (Sarcosin), P09527 (Rab-7), O88960 (N-ethylmaleimide sensitive), P09456 (PKA I regulatory subunit), P27881 (Hexokinase type II), P07872 (Acyl-coenzyme A oxidase), Q6DGF1 (Isocitrate dehydrogenase), Q9EQX9 (Ubiquitin-conjugating), Q63446 (Polyubiquitin), P24268 (Cathepsin D), Q91XW0 (Heat shock protein 86), Q5FVH0 (unknown), P58405 (Striatin 3), Q62667 (Major vault protein), Q66H50 (unknown), Q09167 (splicing factor), Q9JHU5 (Arfaptin 1)."|comment:"Insulin increased GLUT4 interaction with the following proteins:Q9Z1P2 (R-actinin-1), P45592 (Cofilin), Q9QXQ0 (R-actinin-4), P26473 (ADP-ribosylation factor), P26437 (ADP-ribosylation factor),   Q7TNP1 (Basigin 2), Q6P6R2 (Dihydrolipoamide dehydrogenase),   P04797 (GAPDH), Q63081 (Protein disulfide isomerase), P29457 (47 kDa heat shock protein), Q9R1J8 (Leprecan), O88638 (Putative eps protein),   Q64375 (Synaptonemal complex)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:NDPK - Interactions involving proteins containing InterPro domain IPR001564, Nucleoside diphosphate kinase, core.	taxid:10116(rat-l6)|taxid:10116(Rattus norvegicus)	-	2006/02/15	2021/11/30	rogid:PbFY2lfrty8yw40Jq7ShR7xfuV410116	rogid:oNdoYPGY50YJHHBeAamFOMURf4w10116	intact-crc:44F3A2176D02515F|rigid:9RVm0UBcqQF4k06RGKO89Bg16Q8	false	myc tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P19357	uniprotkb:Q99PD4	intact:EBI-915426|uniprotkb:P97900|ensembl:ENSRNOP00000023256	intact:EBI-919781	psi-mi:glut4_rat(display_long)|uniprotkb:Glucose transporter type 4, insulin-responsive(gene name synonym)|uniprotkb:Slc2a4(gene name)|psi-mi:Slc2a4(display_short)|uniprotkb:Glut4(gene name synonym)	psi-mi:arc1a_rat(display_long)|uniprotkb:Arpc1a(gene name)|psi-mi:Arpc1a(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Foster et al. (2006)	pubmed:16396496|mint:MINT-5218203	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-921030	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2711|refseq:NP_036883.1|refseq:XP_006246658.1|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007611"(learning or memory)|go:"GO:0007614"(short-term memory)|go:"GO:0007616"(long-term memory)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010021"(amylopectin biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031550"(positive regulation of brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044381"(glucose import in response to insulin stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046323"(glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0098694"(regulation of synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0098793"(presynapse)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002441("Glucose transporter, type 4 (GLUT4)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-189200|ensembl:ENSRNOG00000017226(gene)|ensembl:ENSRNOT00000023256(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)	rgd:620834|refseq:NP_112408.1|interpro:IPR017383(Actin-related protein 2/3 complex, subunit 1)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR001680(WD40 repeat)|interpro:IPR030140|reactome:R-RNO-5663213|interpro:IPR036322|reactome:R-RNO-2029482|reactome:R-RNO-3928662|reactome:R-RNO-8856828|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005885"(Arp2/3 protein complex)|go:"GO:0034314"(Arp2/3 complex-mediated actin nucleation)|go:"GO:0035861"(site of double-strand break)|go:"GO:0036195"(muscle cell projection membrane)|go:"GO:0051015"(actin filament binding)	-	-	-	caution:"The participant EBI-349571(P68370) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919386(Q7TP47) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920972(Q5XIP9) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-916419(P11980) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919578(Q8R491) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920554(Q5U3Z7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920647(Q5U2X8) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920585(Q7TP24) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-779677(P05426) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-915744(P02454) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|agonist:Insulin was shown to increase or decrease GLUT4 protein interactions in specific cases.|comment:"Insulin decreased GLUT4 interactions with the following proteins: Q9ER30 (Sarcosin), P09527 (Rab-7), O88960 (N-ethylmaleimide sensitive), P09456 (PKA I regulatory subunit), P27881 (Hexokinase type II), P07872 (Acyl-coenzyme A oxidase), Q6DGF1 (Isocitrate dehydrogenase), Q9EQX9 (Ubiquitin-conjugating), Q63446 (Polyubiquitin), P24268 (Cathepsin D), Q91XW0 (Heat shock protein 86), Q5FVH0 (unknown), P58405 (Striatin 3), Q62667 (Major vault protein), Q66H50 (unknown), Q09167 (splicing factor), Q9JHU5 (Arfaptin 1)."|comment:"Insulin increased GLUT4 interaction with the following proteins:Q9Z1P2 (R-actinin-1), P45592 (Cofilin), Q9QXQ0 (R-actinin-4), P26473 (ADP-ribosylation factor), P26437 (ADP-ribosylation factor),   Q7TNP1 (Basigin 2), Q6P6R2 (Dihydrolipoamide dehydrogenase),   P04797 (GAPDH), Q63081 (Protein disulfide isomerase), P29457 (47 kDa heat shock protein), Q9R1J8 (Leprecan), O88638 (Putative eps protein),   Q64375 (Synaptonemal complex)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:NDPK - Interactions involving proteins containing InterPro domain IPR001564, Nucleoside diphosphate kinase, core.	taxid:10116(rat-l6)|taxid:10116(Rattus norvegicus)	-	2006/02/15	2021/11/30	rogid:PbFY2lfrty8yw40Jq7ShR7xfuV410116	rogid:eXXSrjsB74SzRJwFXW9RL1R/I+410116	intact-crc:44F3A2176D02515F|rigid:9RVm0UBcqQF4k06RGKO89Bg16Q8	false	myc tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P19357	uniprotkb:Q99NA6	intact:EBI-915426|uniprotkb:P97900|ensembl:ENSRNOP00000023256	intact:EBI-919774	psi-mi:glut4_rat(display_long)|uniprotkb:Glucose transporter type 4, insulin-responsive(gene name synonym)|uniprotkb:Slc2a4(gene name)|psi-mi:Slc2a4(display_short)|uniprotkb:Glut4(gene name synonym)	psi-mi:q99na6_rat(display_long)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Foster et al. (2006)	pubmed:16396496|mint:MINT-5218203	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-921030	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2711|refseq:NP_036883.1|refseq:XP_006246658.1|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007611"(learning or memory)|go:"GO:0007614"(short-term memory)|go:"GO:0007616"(long-term memory)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010021"(amylopectin biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031550"(positive regulation of brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044381"(glucose import in response to insulin stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046323"(glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0098694"(regulation of synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0098793"(presynapse)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002441("Glucose transporter, type 4 (GLUT4)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-189200|ensembl:ENSRNOG00000017226(gene)|ensembl:ENSRNOT00000023256(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)	interpro:IPR019818|interpro:IPR024084|go:"GO:0000287"(magnesium ion binding)|go:"GO:0006099"(tricarboxylic acid cycle)|go:"GO:0016616"(oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor)|go:"GO:0051287"(NAD binding)	-	-	-	caution:"The participant EBI-349571(P68370) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919386(Q7TP47) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920972(Q5XIP9) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-916419(P11980) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919578(Q8R491) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920554(Q5U3Z7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920647(Q5U2X8) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920585(Q7TP24) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-779677(P05426) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-915744(P02454) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|agonist:Insulin was shown to increase or decrease GLUT4 protein interactions in specific cases.|comment:"Insulin decreased GLUT4 interactions with the following proteins: Q9ER30 (Sarcosin), P09527 (Rab-7), O88960 (N-ethylmaleimide sensitive), P09456 (PKA I regulatory subunit), P27881 (Hexokinase type II), P07872 (Acyl-coenzyme A oxidase), Q6DGF1 (Isocitrate dehydrogenase), Q9EQX9 (Ubiquitin-conjugating), Q63446 (Polyubiquitin), P24268 (Cathepsin D), Q91XW0 (Heat shock protein 86), Q5FVH0 (unknown), P58405 (Striatin 3), Q62667 (Major vault protein), Q66H50 (unknown), Q09167 (splicing factor), Q9JHU5 (Arfaptin 1)."|comment:"Insulin increased GLUT4 interaction with the following proteins:Q9Z1P2 (R-actinin-1), P45592 (Cofilin), Q9QXQ0 (R-actinin-4), P26473 (ADP-ribosylation factor), P26437 (ADP-ribosylation factor),   Q7TNP1 (Basigin 2), Q6P6R2 (Dihydrolipoamide dehydrogenase),   P04797 (GAPDH), Q63081 (Protein disulfide isomerase), P29457 (47 kDa heat shock protein), Q9R1J8 (Leprecan), O88638 (Putative eps protein),   Q64375 (Synaptonemal complex)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:NDPK - Interactions involving proteins containing InterPro domain IPR001564, Nucleoside diphosphate kinase, core.	taxid:10116(rat-l6)|taxid:10116(Rattus norvegicus)	-	2006/02/15	2021/11/30	rogid:PbFY2lfrty8yw40Jq7ShR7xfuV410116	rogid:SZdg948bMGgsTz0C9EOHJ8QSIP410116	intact-crc:44F3A2176D02515F|rigid:9RVm0UBcqQF4k06RGKO89Bg16Q8	false	myc tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P19357	uniprotkb:Q99NA5	intact:EBI-915426|uniprotkb:P97900|ensembl:ENSRNOP00000023256	intact:EBI-919767	psi-mi:glut4_rat(display_long)|uniprotkb:Glucose transporter type 4, insulin-responsive(gene name synonym)|uniprotkb:Slc2a4(gene name)|psi-mi:Slc2a4(display_short)|uniprotkb:Glut4(gene name synonym)	psi-mi:idh3a_rat(display_long)|uniprotkb:Idh3a(gene name)|psi-mi:Idh3a(display_short)|uniprotkb:Isocitric dehydrogenase subunit alpha(gene name synonym)|uniprotkb:"NAD(+)-specific ICDH subunit alpha"(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Foster et al. (2006)	pubmed:16396496|mint:MINT-5218203	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-921030	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2711|refseq:NP_036883.1|refseq:XP_006246658.1|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007611"(learning or memory)|go:"GO:0007614"(short-term memory)|go:"GO:0007616"(long-term memory)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010021"(amylopectin biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031550"(positive regulation of brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044381"(glucose import in response to insulin stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046323"(glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0098694"(regulation of synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0098793"(presynapse)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002441("Glucose transporter, type 4 (GLUT4)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-189200|ensembl:ENSRNOG00000017226(gene)|ensembl:ENSRNOT00000023256(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)	rgd:70889|refseq:NP_446090.1|interpro:IPR019818|interpro:IPR004434(Isocitrate dehydrogenase NAD-dependent, mitochondrial)|interpro:IPR024084|mint:Q99NA5|go:"GO:0000287"(magnesium ion binding)|go:"GO:0004449"("isocitrate dehydrogenase (NAD+) activity")|go:"GO:0005739"(mitochondrion)|go:"GO:0005962"("mitochondrial isocitrate dehydrogenase complex (NAD+)")|go:"GO:0006099"(tricarboxylic acid cycle)|go:"GO:0006102"(isocitrate metabolic process)|go:"GO:0006103"(2-oxoglutarate metabolic process)|go:"GO:0006734"(NADH metabolic process)|go:"GO:0051287"(NAD binding)|reactome:R-RNO-71403	-	-	-	caution:"The participant EBI-349571(P68370) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919386(Q7TP47) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920972(Q5XIP9) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-916419(P11980) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919578(Q8R491) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920554(Q5U3Z7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920647(Q5U2X8) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920585(Q7TP24) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-779677(P05426) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-915744(P02454) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|agonist:Insulin was shown to increase or decrease GLUT4 protein interactions in specific cases.|comment:"Insulin decreased GLUT4 interactions with the following proteins: Q9ER30 (Sarcosin), P09527 (Rab-7), O88960 (N-ethylmaleimide sensitive), P09456 (PKA I regulatory subunit), P27881 (Hexokinase type II), P07872 (Acyl-coenzyme A oxidase), Q6DGF1 (Isocitrate dehydrogenase), Q9EQX9 (Ubiquitin-conjugating), Q63446 (Polyubiquitin), P24268 (Cathepsin D), Q91XW0 (Heat shock protein 86), Q5FVH0 (unknown), P58405 (Striatin 3), Q62667 (Major vault protein), Q66H50 (unknown), Q09167 (splicing factor), Q9JHU5 (Arfaptin 1)."|comment:"Insulin increased GLUT4 interaction with the following proteins:Q9Z1P2 (R-actinin-1), P45592 (Cofilin), Q9QXQ0 (R-actinin-4), P26473 (ADP-ribosylation factor), P26437 (ADP-ribosylation factor),   Q7TNP1 (Basigin 2), Q6P6R2 (Dihydrolipoamide dehydrogenase),   P04797 (GAPDH), Q63081 (Protein disulfide isomerase), P29457 (47 kDa heat shock protein), Q9R1J8 (Leprecan), O88638 (Putative eps protein),   Q64375 (Synaptonemal complex)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:NDPK - Interactions involving proteins containing InterPro domain IPR001564, Nucleoside diphosphate kinase, core.	taxid:10116(rat-l6)|taxid:10116(Rattus norvegicus)	-	2006/02/15	2021/11/30	rogid:PbFY2lfrty8yw40Jq7ShR7xfuV410116	rogid:hwr6FxZD9vcrVjwYX/Qoty2o6ME10116	intact-crc:44F3A2176D02515F|rigid:9RVm0UBcqQF4k06RGKO89Bg16Q8	false	myc tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P19357	uniprotkb:Q71TY3	intact:EBI-915426|uniprotkb:P97900|ensembl:ENSRNOP00000023256	intact:EBI-919289|ensembl:ENSRNOP00000022897	psi-mi:glut4_rat(display_long)|uniprotkb:Glucose transporter type 4, insulin-responsive(gene name synonym)|uniprotkb:Slc2a4(gene name)|psi-mi:Slc2a4(display_short)|uniprotkb:Glut4(gene name synonym)	psi-mi:rs27_rat(display_long)|uniprotkb:Rps27(gene name)|psi-mi:Rps27(display_short)|uniprotkb:S27-1(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Foster et al. (2006)	pubmed:16396496|mint:MINT-5218203	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-921030	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2711|refseq:NP_036883.1|refseq:XP_006246658.1|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007611"(learning or memory)|go:"GO:0007614"(short-term memory)|go:"GO:0007616"(long-term memory)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010021"(amylopectin biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031550"(positive regulation of brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044381"(glucose import in response to insulin stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046323"(glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0098694"(regulation of synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0098793"(presynapse)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002441("Glucose transporter, type 4 (GLUT4)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-189200|ensembl:ENSRNOG00000017226(gene)|ensembl:ENSRNOT00000023256(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)	rgd:621045|refseq:NP_446049.1|ensembl:ENSRNOG00000016961(gene)|ensembl:ENSRNOT00000022897(transcript)|go:"GO:0000028"(ribosomal small subunit assembly)|go:"GO:0003723"(RNA binding)|go:"GO:0003735"(structural constituent of ribosome)|go:"GO:0005634"(nucleus)|go:"GO:0006364"(rRNA processing)|go:"GO:0006412"(translation)|go:"GO:0014069"(postsynaptic density)|go:"GO:0022626"(cytosolic ribosome)|go:"GO:0022627"(cytosolic small ribosomal subunit)|go:"GO:0046872"(metal ion binding)|go:"GO:0098793"(presynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0098982"(GABA-ergic synapse)|interpro:IPR000592(Ribosomal protein S27e)|interpro:IPR011332(Ribosomal protein, zinc-binding)|interpro:IPR023407|reactome:R-RNO-141444|reactome:R-RNO-156827|reactome:R-RNO-1799339|reactome:R-RNO-2467813|reactome:R-RNO-2500257|reactome:R-RNO-5663220|reactome:R-RNO-6791226|reactome:R-RNO-68877|reactome:R-RNO-72649|reactome:R-RNO-72689|reactome:R-RNO-72695|reactome:R-RNO-72702|reactome:R-RNO-72706|reactome:R-RNO-9648025|reactome:R-RNO-975956|reactome:R-RNO-975957	-	-	-	caution:"The participant EBI-349571(P68370) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919386(Q7TP47) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920972(Q5XIP9) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-916419(P11980) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919578(Q8R491) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920554(Q5U3Z7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920647(Q5U2X8) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920585(Q7TP24) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-779677(P05426) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-915744(P02454) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|agonist:Insulin was shown to increase or decrease GLUT4 protein interactions in specific cases.|comment:"Insulin decreased GLUT4 interactions with the following proteins: Q9ER30 (Sarcosin), P09527 (Rab-7), O88960 (N-ethylmaleimide sensitive), P09456 (PKA I regulatory subunit), P27881 (Hexokinase type II), P07872 (Acyl-coenzyme A oxidase), Q6DGF1 (Isocitrate dehydrogenase), Q9EQX9 (Ubiquitin-conjugating), Q63446 (Polyubiquitin), P24268 (Cathepsin D), Q91XW0 (Heat shock protein 86), Q5FVH0 (unknown), P58405 (Striatin 3), Q62667 (Major vault protein), Q66H50 (unknown), Q09167 (splicing factor), Q9JHU5 (Arfaptin 1)."|comment:"Insulin increased GLUT4 interaction with the following proteins:Q9Z1P2 (R-actinin-1), P45592 (Cofilin), Q9QXQ0 (R-actinin-4), P26473 (ADP-ribosylation factor), P26437 (ADP-ribosylation factor),   Q7TNP1 (Basigin 2), Q6P6R2 (Dihydrolipoamide dehydrogenase),   P04797 (GAPDH), Q63081 (Protein disulfide isomerase), P29457 (47 kDa heat shock protein), Q9R1J8 (Leprecan), O88638 (Putative eps protein),   Q64375 (Synaptonemal complex)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:NDPK - Interactions involving proteins containing InterPro domain IPR001564, Nucleoside diphosphate kinase, core.	taxid:10116(rat-l6)|taxid:10116(Rattus norvegicus)	-	2006/02/15	2021/11/30	rogid:PbFY2lfrty8yw40Jq7ShR7xfuV410116	rogid:OA5IWAJDBpY5FFdVnun7Sq/jI7g10116	intact-crc:44F3A2176D02515F|rigid:9RVm0UBcqQF4k06RGKO89Bg16Q8	false	myc tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P19357	uniprotkb:Q71SY3	intact:EBI-915426|uniprotkb:P97900|ensembl:ENSRNOP00000023256	intact:EBI-919283|uniprotkb:F7EM24|ensembl:ENSRNOP00000063499	psi-mi:glut4_rat(display_long)|uniprotkb:Glucose transporter type 4, insulin-responsive(gene name synonym)|uniprotkb:Slc2a4(gene name)|psi-mi:Slc2a4(display_short)|uniprotkb:Glut4(gene name synonym)	psi-mi:q71sy3_rat(display_long)|uniprotkb:Tsn(gene name)|psi-mi:Tsn(display_short)|uniprotkb:Translin(gene name synonym)|uniprotkb:rCG_37601(orf name)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Foster et al. (2006)	pubmed:16396496|mint:MINT-5218203	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-921030	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2711|refseq:NP_036883.1|refseq:XP_006246658.1|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007611"(learning or memory)|go:"GO:0007614"(short-term memory)|go:"GO:0007616"(long-term memory)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010021"(amylopectin biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031550"(positive regulation of brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044381"(glucose import in response to insulin stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046323"(glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0098694"(regulation of synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0098793"(presynapse)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002441("Glucose transporter, type 4 (GLUT4)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-189200|ensembl:ENSRNOG00000017226(gene)|ensembl:ENSRNOT00000023256(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)	refseq:NP_068530.1|rgd:621107|ensembl:ENSRNOG00000002319(gene)|ensembl:ENSRNOT00000068524(transcript)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0016070"(RNA metabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0044877"(protein-containing complex binding)|interpro:IPR002848(Translin)|interpro:IPR016068(Translin, N-terminal)|interpro:IPR016069(Translin, C-terminal)|interpro:IPR033956|interpro:IPR036081|mint:Q71SY3	-	-	-	caution:"The participant EBI-349571(P68370) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919386(Q7TP47) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920972(Q5XIP9) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-916419(P11980) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919578(Q8R491) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920554(Q5U3Z7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920647(Q5U2X8) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920585(Q7TP24) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-779677(P05426) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-915744(P02454) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|agonist:Insulin was shown to increase or decrease GLUT4 protein interactions in specific cases.|comment:"Insulin decreased GLUT4 interactions with the following proteins: Q9ER30 (Sarcosin), P09527 (Rab-7), O88960 (N-ethylmaleimide sensitive), P09456 (PKA I regulatory subunit), P27881 (Hexokinase type II), P07872 (Acyl-coenzyme A oxidase), Q6DGF1 (Isocitrate dehydrogenase), Q9EQX9 (Ubiquitin-conjugating), Q63446 (Polyubiquitin), P24268 (Cathepsin D), Q91XW0 (Heat shock protein 86), Q5FVH0 (unknown), P58405 (Striatin 3), Q62667 (Major vault protein), Q66H50 (unknown), Q09167 (splicing factor), Q9JHU5 (Arfaptin 1)."|comment:"Insulin increased GLUT4 interaction with the following proteins:Q9Z1P2 (R-actinin-1), P45592 (Cofilin), Q9QXQ0 (R-actinin-4), P26473 (ADP-ribosylation factor), P26437 (ADP-ribosylation factor),   Q7TNP1 (Basigin 2), Q6P6R2 (Dihydrolipoamide dehydrogenase),   P04797 (GAPDH), Q63081 (Protein disulfide isomerase), P29457 (47 kDa heat shock protein), Q9R1J8 (Leprecan), O88638 (Putative eps protein),   Q64375 (Synaptonemal complex)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:NDPK - Interactions involving proteins containing InterPro domain IPR001564, Nucleoside diphosphate kinase, core.	taxid:10116(rat-l6)|taxid:10116(Rattus norvegicus)	-	2006/02/15	2021/11/30	rogid:PbFY2lfrty8yw40Jq7ShR7xfuV410116	rogid:WUDu/5A2iVz73/TOJpB0mmgRjPc10116	intact-crc:44F3A2176D02515F|rigid:9RVm0UBcqQF4k06RGKO89Bg16Q8	false	myc tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P19357	uniprotkb:Q71DI1	intact:EBI-915426|uniprotkb:P97900|ensembl:ENSRNOP00000023256	intact:EBI-919280	psi-mi:glut4_rat(display_long)|uniprotkb:Glucose transporter type 4, insulin-responsive(gene name synonym)|uniprotkb:Slc2a4(gene name)|psi-mi:Slc2a4(display_short)|uniprotkb:Glut4(gene name synonym)	psi-mi:q71di1_rat(display_long)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Foster et al. (2006)	pubmed:16396496|mint:MINT-5218203	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-921030	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2711|refseq:NP_036883.1|refseq:XP_006246658.1|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007611"(learning or memory)|go:"GO:0007614"(short-term memory)|go:"GO:0007616"(long-term memory)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010021"(amylopectin biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031550"(positive regulation of brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044381"(glucose import in response to insulin stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046323"(glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0098694"(regulation of synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0098793"(presynapse)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002441("Glucose transporter, type 4 (GLUT4)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-189200|ensembl:ENSRNOG00000017226(gene)|ensembl:ENSRNOT00000023256(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)	interpro:IPR028130|interpro:IPR043557|go:"GO:0005576"(extracellular region)|go:"GO:0008233"(peptidase activity)|go:"GO:0031640"(killing of cells of another organism)	-	-	-	caution:"The participant EBI-349571(P68370) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919386(Q7TP47) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920972(Q5XIP9) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-916419(P11980) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919578(Q8R491) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920554(Q5U3Z7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920647(Q5U2X8) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920585(Q7TP24) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-779677(P05426) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-915744(P02454) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|agonist:Insulin was shown to increase or decrease GLUT4 protein interactions in specific cases.|comment:"Insulin decreased GLUT4 interactions with the following proteins: Q9ER30 (Sarcosin), P09527 (Rab-7), O88960 (N-ethylmaleimide sensitive), P09456 (PKA I regulatory subunit), P27881 (Hexokinase type II), P07872 (Acyl-coenzyme A oxidase), Q6DGF1 (Isocitrate dehydrogenase), Q9EQX9 (Ubiquitin-conjugating), Q63446 (Polyubiquitin), P24268 (Cathepsin D), Q91XW0 (Heat shock protein 86), Q5FVH0 (unknown), P58405 (Striatin 3), Q62667 (Major vault protein), Q66H50 (unknown), Q09167 (splicing factor), Q9JHU5 (Arfaptin 1)."|comment:"Insulin increased GLUT4 interaction with the following proteins:Q9Z1P2 (R-actinin-1), P45592 (Cofilin), Q9QXQ0 (R-actinin-4), P26473 (ADP-ribosylation factor), P26437 (ADP-ribosylation factor),   Q7TNP1 (Basigin 2), Q6P6R2 (Dihydrolipoamide dehydrogenase),   P04797 (GAPDH), Q63081 (Protein disulfide isomerase), P29457 (47 kDa heat shock protein), Q9R1J8 (Leprecan), O88638 (Putative eps protein),   Q64375 (Synaptonemal complex)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:NDPK - Interactions involving proteins containing InterPro domain IPR001564, Nucleoside diphosphate kinase, core.	taxid:10116(rat-l6)|taxid:10116(Rattus norvegicus)	-	2006/02/15	2021/11/30	rogid:PbFY2lfrty8yw40Jq7ShR7xfuV410116	rogid:M8PkKVWx98nhtd79ods05mqw8Ls10116	intact-crc:44F3A2176D02515F|rigid:9RVm0UBcqQF4k06RGKO89Bg16Q8	false	myc tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P19357	uniprotkb:Q5M9G3	intact:EBI-915426|uniprotkb:P97900|ensembl:ENSRNOP00000023256	intact:EBI-919277|uniprotkb:Q6YF16|uniprotkb:A9ZSZ9|ensembl:ENSRNOP00000012428	psi-mi:glut4_rat(display_long)|uniprotkb:Glucose transporter type 4, insulin-responsive(gene name synonym)|uniprotkb:Slc2a4(gene name)|psi-mi:Slc2a4(display_short)|uniprotkb:Glut4(gene name synonym)	psi-mi:capr1_rat(display_long)|uniprotkb:Caprin1(gene name)|psi-mi:Caprin1(display_short)|uniprotkb:Gpiap1(gene name synonym)|uniprotkb:Cytoplasmic activation- and proliferation-associated protein 1(gene name synonym)|uniprotkb:GPI-anchored protein p137(gene name synonym)|uniprotkb:Rng105(gene name synonym)|uniprotkb:RNA granule protein 105(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Foster et al. (2006)	pubmed:16396496|mint:MINT-5218203	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-921030	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2711|refseq:NP_036883.1|refseq:XP_006246658.1|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007611"(learning or memory)|go:"GO:0007614"(short-term memory)|go:"GO:0007616"(long-term memory)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010021"(amylopectin biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031550"(positive regulation of brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044381"(glucose import in response to insulin stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046323"(glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0098694"(regulation of synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0098793"(presynapse)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002441("Glucose transporter, type 4 (GLUT4)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-189200|ensembl:ENSRNOG00000017226(gene)|ensembl:ENSRNOT00000023256(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)	rgd:1305707|refseq:NP_001012185.2|ensembl:ENSRNOG00000009152(gene)|ensembl:ENSRNOT00000012428(transcript)|go:"GO:0000932"(P-body)|go:"GO:0003723"(RNA binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0030027"(lamellipodium)|go:"GO:0030425"(dendrite)|go:"GO:0031252"(cell leading edge)|go:"GO:0045202"(synapse)|go:"GO:0050775"(positive regulation of dendrite morphogenesis)|go:"GO:0061003"(positive regulation of dendritic spine morphogenesis)|go:"GO:0098794"(postsynapse)|go:"GO:0098978"(glutamatergic synapse)|interpro:IPR022070|interpro:IPR028816|interpro:IPR041637|mint:Q5M9G3	-	-	-	caution:"The participant EBI-349571(P68370) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919386(Q7TP47) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920972(Q5XIP9) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-916419(P11980) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919578(Q8R491) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920554(Q5U3Z7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920647(Q5U2X8) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920585(Q7TP24) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-779677(P05426) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-915744(P02454) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|agonist:Insulin was shown to increase or decrease GLUT4 protein interactions in specific cases.|comment:"Insulin decreased GLUT4 interactions with the following proteins: Q9ER30 (Sarcosin), P09527 (Rab-7), O88960 (N-ethylmaleimide sensitive), P09456 (PKA I regulatory subunit), P27881 (Hexokinase type II), P07872 (Acyl-coenzyme A oxidase), Q6DGF1 (Isocitrate dehydrogenase), Q9EQX9 (Ubiquitin-conjugating), Q63446 (Polyubiquitin), P24268 (Cathepsin D), Q91XW0 (Heat shock protein 86), Q5FVH0 (unknown), P58405 (Striatin 3), Q62667 (Major vault protein), Q66H50 (unknown), Q09167 (splicing factor), Q9JHU5 (Arfaptin 1)."|comment:"Insulin increased GLUT4 interaction with the following proteins:Q9Z1P2 (R-actinin-1), P45592 (Cofilin), Q9QXQ0 (R-actinin-4), P26473 (ADP-ribosylation factor), P26437 (ADP-ribosylation factor),   Q7TNP1 (Basigin 2), Q6P6R2 (Dihydrolipoamide dehydrogenase),   P04797 (GAPDH), Q63081 (Protein disulfide isomerase), P29457 (47 kDa heat shock protein), Q9R1J8 (Leprecan), O88638 (Putative eps protein),   Q64375 (Synaptonemal complex)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:NDPK - Interactions involving proteins containing InterPro domain IPR001564, Nucleoside diphosphate kinase, core.	taxid:10116(rat-l6)|taxid:10116(Rattus norvegicus)	-	2006/02/15	2021/11/30	rogid:PbFY2lfrty8yw40Jq7ShR7xfuV410116	rogid:ta0/0BjNxyPdbColeGebelK5Uac10116	intact-crc:44F3A2176D02515F|rigid:9RVm0UBcqQF4k06RGKO89Bg16Q8	false	myc tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P19357	uniprotkb:Q6W3E9	intact:EBI-915426|uniprotkb:P97900|ensembl:ENSRNOP00000023256	intact:EBI-919268	psi-mi:glut4_rat(display_long)|uniprotkb:Glucose transporter type 4, insulin-responsive(gene name synonym)|uniprotkb:Slc2a4(gene name)|psi-mi:Slc2a4(display_short)|uniprotkb:Glut4(gene name synonym)	psi-mi:p4ha3_rat(display_long)|uniprotkb:P4ha3(gene name)|psi-mi:P4ha3(display_short)|uniprotkb:Procollagen-proline,2-oxoglutarate-4-dioxygenase subunit alpha-3(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Foster et al. (2006)	pubmed:16396496|mint:MINT-5218203	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-921030	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2711|refseq:NP_036883.1|refseq:XP_006246658.1|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007611"(learning or memory)|go:"GO:0007614"(short-term memory)|go:"GO:0007616"(long-term memory)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010021"(amylopectin biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031550"(positive regulation of brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044381"(glucose import in response to insulin stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046323"(glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0098694"(regulation of synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0098793"(presynapse)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002441("Glucose transporter, type 4 (GLUT4)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-189200|ensembl:ENSRNOG00000017226(gene)|ensembl:ENSRNOT00000023256(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)	rgd:735150|refseq:NP_942070.1|interpro:IPR005123("2OG-Fe(II) oxygenase")|interpro:IPR006620(Prolyl 4-hydroxylase, alpha subunit)|interpro:IPR013547(Prolyl 4-hydroxylase alpha-subunit, N-terminal)|interpro:IPR011990(Tetratricopeptide-like helical)|reactome:R-RNO-1650814|go:"GO:0004656"(procollagen-proline 4-dioxygenase activity)|go:"GO:0005506"(iron ion binding)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0016222"(procollagen-proline 4-dioxygenase complex)|go:"GO:0018401"(peptidyl-proline hydroxylation to 4-hydroxy-L-proline)|go:"GO:0031418"(L-ascorbic acid binding)	-	-	-	caution:"The participant EBI-349571(P68370) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919386(Q7TP47) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920972(Q5XIP9) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-916419(P11980) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919578(Q8R491) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920554(Q5U3Z7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920647(Q5U2X8) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920585(Q7TP24) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-779677(P05426) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-915744(P02454) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|agonist:Insulin was shown to increase or decrease GLUT4 protein interactions in specific cases.|comment:"Insulin decreased GLUT4 interactions with the following proteins: Q9ER30 (Sarcosin), P09527 (Rab-7), O88960 (N-ethylmaleimide sensitive), P09456 (PKA I regulatory subunit), P27881 (Hexokinase type II), P07872 (Acyl-coenzyme A oxidase), Q6DGF1 (Isocitrate dehydrogenase), Q9EQX9 (Ubiquitin-conjugating), Q63446 (Polyubiquitin), P24268 (Cathepsin D), Q91XW0 (Heat shock protein 86), Q5FVH0 (unknown), P58405 (Striatin 3), Q62667 (Major vault protein), Q66H50 (unknown), Q09167 (splicing factor), Q9JHU5 (Arfaptin 1)."|comment:"Insulin increased GLUT4 interaction with the following proteins:Q9Z1P2 (R-actinin-1), P45592 (Cofilin), Q9QXQ0 (R-actinin-4), P26473 (ADP-ribosylation factor), P26437 (ADP-ribosylation factor),   Q7TNP1 (Basigin 2), Q6P6R2 (Dihydrolipoamide dehydrogenase),   P04797 (GAPDH), Q63081 (Protein disulfide isomerase), P29457 (47 kDa heat shock protein), Q9R1J8 (Leprecan), O88638 (Putative eps protein),   Q64375 (Synaptonemal complex)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:NDPK - Interactions involving proteins containing InterPro domain IPR001564, Nucleoside diphosphate kinase, core.	taxid:10116(rat-l6)|taxid:10116(Rattus norvegicus)	-	2006/02/15	2021/11/30	rogid:PbFY2lfrty8yw40Jq7ShR7xfuV410116	rogid:E5alu8q3jRTAOaQHXNrCUGBNC7810116	intact-crc:44F3A2176D02515F|rigid:9RVm0UBcqQF4k06RGKO89Bg16Q8	false	myc tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P19357	uniprotkb:Q6TUG0	intact:EBI-915426|uniprotkb:P97900|ensembl:ENSRNOP00000023256	intact:EBI-919258|ensembl:ENSRNOP00000002462	psi-mi:glut4_rat(display_long)|uniprotkb:Glucose transporter type 4, insulin-responsive(gene name synonym)|uniprotkb:Slc2a4(gene name)|psi-mi:Slc2a4(display_short)|uniprotkb:Glut4(gene name synonym)	psi-mi:djb11_rat(display_long)|uniprotkb:Dnajb11(gene name)|psi-mi:Dnajb11(display_short)|uniprotkb:ER-associated Hsp40 co-chaperone(gene name synonym)|uniprotkb:ER-associated DNAJ(gene name synonym)|uniprotkb:Liver regeneration-related protein LRRGT00084(gene name synonym)|uniprotkb:Endoplasmic reticulum DNA J domain-containing protein 3(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Foster et al. (2006)	pubmed:16396496|mint:MINT-5218203	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-921030	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2711|refseq:NP_036883.1|refseq:XP_006246658.1|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007611"(learning or memory)|go:"GO:0007614"(short-term memory)|go:"GO:0007616"(long-term memory)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010021"(amylopectin biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031550"(positive regulation of brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044381"(glucose import in response to insulin stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046323"(glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0098694"(regulation of synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0098793"(presynapse)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002441("Glucose transporter, type 4 (GLUT4)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-189200|ensembl:ENSRNOG00000017226(gene)|ensembl:ENSRNOT00000023256(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)	rgd:1307373|refseq:NP_001015021.1|ensembl:ENSRNOG00000001803(gene)|ensembl:ENSRNOT00000002462(transcript)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0006457"(protein folding)|go:"GO:0016556"(mRNA modification)|go:"GO:0032781"(positive regulation of ATP-dependent activity)|go:"GO:0034663"(endoplasmic reticulum chaperone complex)|go:"GO:0050768"(negative regulation of neurogenesis)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051604"(protein maturation)|go:"GO:0051787"(misfolded protein binding)|go:"GO:0101031"(chaperone complex)|interpro:IPR001623(Heat shock protein DnaJ, N-terminal)|interpro:IPR002939(Chaperone DnaJ, C-terminal)|interpro:IPR008971(HSP40/DnaJ peptide-binding)|interpro:IPR018253|interpro:IPR036869|mint:Q6TUG0	-	-	-	caution:"The participant EBI-349571(P68370) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919386(Q7TP47) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920972(Q5XIP9) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-916419(P11980) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919578(Q8R491) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920554(Q5U3Z7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920647(Q5U2X8) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920585(Q7TP24) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-779677(P05426) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-915744(P02454) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|agonist:Insulin was shown to increase or decrease GLUT4 protein interactions in specific cases.|comment:"Insulin decreased GLUT4 interactions with the following proteins: Q9ER30 (Sarcosin), P09527 (Rab-7), O88960 (N-ethylmaleimide sensitive), P09456 (PKA I regulatory subunit), P27881 (Hexokinase type II), P07872 (Acyl-coenzyme A oxidase), Q6DGF1 (Isocitrate dehydrogenase), Q9EQX9 (Ubiquitin-conjugating), Q63446 (Polyubiquitin), P24268 (Cathepsin D), Q91XW0 (Heat shock protein 86), Q5FVH0 (unknown), P58405 (Striatin 3), Q62667 (Major vault protein), Q66H50 (unknown), Q09167 (splicing factor), Q9JHU5 (Arfaptin 1)."|comment:"Insulin increased GLUT4 interaction with the following proteins:Q9Z1P2 (R-actinin-1), P45592 (Cofilin), Q9QXQ0 (R-actinin-4), P26473 (ADP-ribosylation factor), P26437 (ADP-ribosylation factor),   Q7TNP1 (Basigin 2), Q6P6R2 (Dihydrolipoamide dehydrogenase),   P04797 (GAPDH), Q63081 (Protein disulfide isomerase), P29457 (47 kDa heat shock protein), Q9R1J8 (Leprecan), O88638 (Putative eps protein),   Q64375 (Synaptonemal complex)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:NDPK - Interactions involving proteins containing InterPro domain IPR001564, Nucleoside diphosphate kinase, core.	taxid:10116(rat-l6)|taxid:10116(Rattus norvegicus)	-	2006/02/15	2021/11/30	rogid:PbFY2lfrty8yw40Jq7ShR7xfuV410116	rogid:NMsvYKrs7f8hoFUT68Xt5cEHnDU10116	intact-crc:44F3A2176D02515F|rigid:9RVm0UBcqQF4k06RGKO89Bg16Q8	false	myc tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P19357	uniprotkb:Q6RUV5	intact:EBI-915426|uniprotkb:P97900|ensembl:ENSRNOP00000023256	intact:EBI-919251|ensembl:ENSRNOP00000001417	psi-mi:glut4_rat(display_long)|uniprotkb:Glucose transporter type 4, insulin-responsive(gene name synonym)|uniprotkb:Slc2a4(gene name)|psi-mi:Slc2a4(display_short)|uniprotkb:Glut4(gene name synonym)	psi-mi:rac1_rat(display_long)|uniprotkb:Rac1(gene name)|psi-mi:Rac1(display_short)|uniprotkb:p21-Rac1(gene name synonym)|uniprotkb:Rac(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Foster et al. (2006)	pubmed:16396496|mint:MINT-5218203	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-921030	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2711|refseq:NP_036883.1|refseq:XP_006246658.1|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007611"(learning or memory)|go:"GO:0007614"(short-term memory)|go:"GO:0007616"(long-term memory)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010021"(amylopectin biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031550"(positive regulation of brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044381"(glucose import in response to insulin stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046323"(glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0098694"(regulation of synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0098793"(presynapse)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002441("Glucose transporter, type 4 (GLUT4)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-189200|ensembl:ENSRNOG00000017226(gene)|ensembl:ENSRNOT00000023256(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)	rgd:619755|refseq:NP_599193.1|dip:DIP-37114N|ensembl:ENSRNOG00000001068(gene)|ensembl:ENSRNOT00000001417(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0000242"(pericentriolar material)|go:"GO:0001764"(neuron migration)|go:"GO:0001891"(phagocytic cup)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002093"(auditory receptor cell morphogenesis)|go:"GO:0002551"(mast cell chemotaxis)|go:"GO:0003376"(sphingosine-1-phosphate receptor signaling pathway)|go:"GO:0003382"(epithelial cell morphogenesis)|go:"GO:0003924"(GTPase activity)|go:"GO:0003925"(G protein activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005884"(actin filament)|go:"GO:0005886"(plasma membrane)|go:"GO:0005938"(cell cortex)|go:"GO:0006897"(endocytosis)|go:"GO:0006911"(phagocytosis, engulfment)|go:"GO:0006935"(chemotaxis)|go:"GO:0006972"(hyperosmotic response)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007015"(actin filament organization)|go:"GO:0007155"(cell adhesion)|go:"GO:0007163"(establishment or maintenance of cell polarity)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0007411"(axon guidance)|go:"GO:0008045"(motor neuron axon guidance)|go:"GO:0008283"(cell population proliferation)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0008361"(regulation of cell size)|go:"GO:0010591"(regulation of lamellipodium assembly)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010595"(positive regulation of endothelial cell migration)|go:"GO:0010762"(regulation of fibroblast migration)|go:"GO:0010764"(negative regulation of fibroblast migration)|go:"GO:0010811"(positive regulation of cell-substrate adhesion)|go:"GO:0014041"(regulation of neuron maturation)|go:"GO:0016020"(membrane)|go:"GO:0016358"(dendrite development)|go:"GO:0016477"(cell migration)|go:"GO:0016601"(Rac protein signal transduction)|go:"GO:0019897"(extrinsic component of plasma membrane)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0021799"(cerebral cortex radially oriented cell migration)|go:"GO:0021831"(embryonic olfactory bulb interneuron precursor migration)|go:"GO:0021894"(cerebral cortex GABAergic interneuron development)|go:"GO:0022604"(regulation of cell morphogenesis)|go:"GO:0030027"(lamellipodium)|go:"GO:0030031"(cell projection assembly)|go:"GO:0030032"(lamellipodium assembly)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030041"(actin filament polymerization)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0030742"(GTP-dependent protein binding)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0030865"(cortical cytoskeleton organization)|go:"GO:0030900"(forebrain development)|go:"GO:0031116"(positive regulation of microtubule polymerization)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031529"(ruffle organization)|go:"GO:0031901"(early endosome membrane)|go:"GO:0031996"(thioesterase binding)|go:"GO:0032587"(ruffle membrane)|go:"GO:0032707"(negative regulation of interleukin-23 production)|go:"GO:0032956"(regulation of actin cytoskeleton organization)|go:"GO:0034446"(substrate adhesion-dependent cell spreading)|go:"GO:0035567"(non-canonical Wnt signaling pathway)|go:"GO:0035774"(positive regulation of insulin secretion involved in cellular response to glucose stimulus)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042470"(melanosome)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0042995"(cell projection)|go:"GO:0043197"(dendritic spine)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043552"(positive regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0043652"(engulfment of apoptotic cell)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045216"(cell-cell junction organization)|go:"GO:0045428"(regulation of nitric oxide biosynthetic process)|go:"GO:0045453"(bone resorption)|go:"GO:0045740"(positive regulation of DNA replication)|go:"GO:0046425"(regulation of receptor signaling pathway via JAK-STAT)|go:"GO:0048012"(hepatocyte growth factor receptor signaling pathway)|go:"GO:0048168"(regulation of neuronal synaptic plasticity)|go:"GO:0048532"(anatomical structure arrangement)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0048813"(dendrite morphogenesis)|go:"GO:0048870"(cell motility)|go:"GO:0048873"(homeostasis of number of cells within a tissue)|go:"GO:0051022"(Rho GDP-dissociation inhibitor binding)|go:"GO:0051117"(ATPase binding)|go:"GO:0051492"(regulation of stress fiber assembly)|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0051668"(localization within membrane)|go:"GO:0051894"(positive regulation of focal adhesion assembly)|go:"GO:0051932"(synaptic transmission, GABAergic)|go:"GO:0055038"(recycling endosome membrane)|go:"GO:0060071"(Wnt signaling pathway, planar cell polarity pathway)|go:"GO:0060091"(kinocilium)|go:"GO:0060263"(regulation of respiratory burst)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0061344"(regulation of cell adhesion involved in heart morphogenesis)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071526"(semaphorin-plexin signaling pathway)|go:"GO:0071542"(dopaminergic neuron differentiation)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0090023"(positive regulation of neutrophil chemotaxis)|go:"GO:0090103"(cochlea morphogenesis)|go:"GO:0097178"(ruffle assembly)|go:"GO:0098794"(postsynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1900026"(positive regulation of substrate adhesion-dependent cell spreading)|go:"GO:1902622"(regulation of neutrophil migration)|go:"GO:1904948"(midbrain dopaminergic neuron differentiation)|go:"GO:2000386"(positive regulation of ovarian follicle development)|interpro:IPR001806(Ras GTPase)|interpro:IPR003578(Ras small GTPase, Rho type)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR027417|mint:Q6RUV5|reactome:R-RNO-114604|reactome:R-RNO-1257604|reactome:R-RNO-1433557|reactome:R-RNO-193648|reactome:R-RNO-2029482|reactome:R-RNO-2424491|reactome:R-RNO-2871796|reactome:R-RNO-376172|reactome:R-RNO-389359|reactome:R-RNO-3928662|reactome:R-RNO-3928664|reactome:R-RNO-3928665|reactome:R-RNO-399954|reactome:R-RNO-4086400|reactome:R-RNO-416550|reactome:R-RNO-418885|reactome:R-RNO-4420097|reactome:R-RNO-445144|reactome:R-RNO-5218920|reactome:R-RNO-5625740|reactome:R-RNO-5625900|reactome:R-RNO-5625970|reactome:R-RNO-5626467|reactome:R-RNO-5627123|reactome:R-RNO-5663213|reactome:R-RNO-5663220|reactome:R-RNO-5668599|reactome:R-RNO-5687128|reactome:R-RNO-6798695|reactome:R-RNO-6811558|reactome:R-RNO-8849471|reactome:R-RNO-8875555|reactome:R-RNO-9013149|reactome:R-RNO-9032759|reactome:R-RNO-983231	-	-	-	caution:"The participant EBI-349571(P68370) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919386(Q7TP47) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920972(Q5XIP9) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-916419(P11980) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919578(Q8R491) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920554(Q5U3Z7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920647(Q5U2X8) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920585(Q7TP24) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-779677(P05426) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-915744(P02454) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|agonist:Insulin was shown to increase or decrease GLUT4 protein interactions in specific cases.|comment:"Insulin decreased GLUT4 interactions with the following proteins: Q9ER30 (Sarcosin), P09527 (Rab-7), O88960 (N-ethylmaleimide sensitive), P09456 (PKA I regulatory subunit), P27881 (Hexokinase type II), P07872 (Acyl-coenzyme A oxidase), Q6DGF1 (Isocitrate dehydrogenase), Q9EQX9 (Ubiquitin-conjugating), Q63446 (Polyubiquitin), P24268 (Cathepsin D), Q91XW0 (Heat shock protein 86), Q5FVH0 (unknown), P58405 (Striatin 3), Q62667 (Major vault protein), Q66H50 (unknown), Q09167 (splicing factor), Q9JHU5 (Arfaptin 1)."|comment:"Insulin increased GLUT4 interaction with the following proteins:Q9Z1P2 (R-actinin-1), P45592 (Cofilin), Q9QXQ0 (R-actinin-4), P26473 (ADP-ribosylation factor), P26437 (ADP-ribosylation factor),   Q7TNP1 (Basigin 2), Q6P6R2 (Dihydrolipoamide dehydrogenase),   P04797 (GAPDH), Q63081 (Protein disulfide isomerase), P29457 (47 kDa heat shock protein), Q9R1J8 (Leprecan), O88638 (Putative eps protein),   Q64375 (Synaptonemal complex)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:NDPK - Interactions involving proteins containing InterPro domain IPR001564, Nucleoside diphosphate kinase, core.	taxid:10116(rat-l6)|taxid:10116(Rattus norvegicus)	-	2006/02/15	2021/11/30	rogid:PbFY2lfrty8yw40Jq7ShR7xfuV410116	rogid:8rkYyZSFL5tIfbRNKZgP/UDxD+A10116	intact-crc:44F3A2176D02515F|rigid:9RVm0UBcqQF4k06RGKO89Bg16Q8	false	myc tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P19357	uniprotkb:Q6RJR6	intact:EBI-915426|uniprotkb:P97900|ensembl:ENSRNOP00000023256	intact:EBI-919246|uniprotkb:Q6P6R3|uniprotkb:Q8VBU0|ensembl:ENSRNOP00000028785	psi-mi:glut4_rat(display_long)|uniprotkb:Glucose transporter type 4, insulin-responsive(gene name synonym)|uniprotkb:Slc2a4(gene name)|psi-mi:Slc2a4(display_short)|uniprotkb:Glut4(gene name synonym)	psi-mi:rtn3_rat(display_long)|uniprotkb:Rtn3(gene name)|psi-mi:Rtn3(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Foster et al. (2006)	pubmed:16396496|mint:MINT-5218203	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-921030	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2711|refseq:NP_036883.1|refseq:XP_006246658.1|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007611"(learning or memory)|go:"GO:0007614"(short-term memory)|go:"GO:0007616"(long-term memory)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010021"(amylopectin biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031550"(positive regulation of brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044381"(glucose import in response to insulin stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046323"(glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0098694"(regulation of synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0098793"(presynapse)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002441("Glucose transporter, type 4 (GLUT4)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-189200|ensembl:ENSRNOG00000017226(gene)|ensembl:ENSRNOT00000023256(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)	rgd:620988|refseq:NP_001009953.2|refseq:NP_543185.2|ensembl:ENSRNOG00000021202(gene)|ensembl:ENSRNOT00000028785(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0006915"(apoptotic process)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0045202"(synapse)|go:"GO:0071786"(endoplasmic reticulum tubular network organization)|go:"GO:0071787"(endoplasmic reticulum tubular network formation)|go:"GO:1902430"(negative regulation of amyloid-beta formation)|interpro:IPR003388(Reticulon)|mint:Q6RJR6|reactome:R-RNO-8849932	-	-	-	caution:"The participant EBI-349571(P68370) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919386(Q7TP47) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920972(Q5XIP9) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-916419(P11980) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919578(Q8R491) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920554(Q5U3Z7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920647(Q5U2X8) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920585(Q7TP24) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-779677(P05426) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-915744(P02454) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|agonist:Insulin was shown to increase or decrease GLUT4 protein interactions in specific cases.|comment:"Insulin decreased GLUT4 interactions with the following proteins: Q9ER30 (Sarcosin), P09527 (Rab-7), O88960 (N-ethylmaleimide sensitive), P09456 (PKA I regulatory subunit), P27881 (Hexokinase type II), P07872 (Acyl-coenzyme A oxidase), Q6DGF1 (Isocitrate dehydrogenase), Q9EQX9 (Ubiquitin-conjugating), Q63446 (Polyubiquitin), P24268 (Cathepsin D), Q91XW0 (Heat shock protein 86), Q5FVH0 (unknown), P58405 (Striatin 3), Q62667 (Major vault protein), Q66H50 (unknown), Q09167 (splicing factor), Q9JHU5 (Arfaptin 1)."|comment:"Insulin increased GLUT4 interaction with the following proteins:Q9Z1P2 (R-actinin-1), P45592 (Cofilin), Q9QXQ0 (R-actinin-4), P26473 (ADP-ribosylation factor), P26437 (ADP-ribosylation factor),   Q7TNP1 (Basigin 2), Q6P6R2 (Dihydrolipoamide dehydrogenase),   P04797 (GAPDH), Q63081 (Protein disulfide isomerase), P29457 (47 kDa heat shock protein), Q9R1J8 (Leprecan), O88638 (Putative eps protein),   Q64375 (Synaptonemal complex)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:NDPK - Interactions involving proteins containing InterPro domain IPR001564, Nucleoside diphosphate kinase, core.	taxid:10116(rat-l6)|taxid:10116(Rattus norvegicus)	-	2006/02/15	2021/11/30	rogid:PbFY2lfrty8yw40Jq7ShR7xfuV410116	rogid:CehbzFUmpJjUrA42+RLJ+oKmx3A10116	intact-crc:44F3A2176D02515F|rigid:9RVm0UBcqQF4k06RGKO89Bg16Q8	false	myc tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P19357	uniprotkb:Q2TA68	intact:EBI-915426|uniprotkb:P97900|ensembl:ENSRNOP00000023256	intact:EBI-919238|uniprotkb:O08681|uniprotkb:Q5MPP1|uniprotkb:Q5MPP2|uniprotkb:Q5QJE9|uniprotkb:Q6B435|uniprotkb:Q6R611|ensembl:ENSRNOP00000002338|ensembl:ENSRNOP00000002343	psi-mi:glut4_rat(display_long)|uniprotkb:Glucose transporter type 4, insulin-responsive(gene name synonym)|uniprotkb:Slc2a4(gene name)|psi-mi:Slc2a4(display_short)|uniprotkb:Glut4(gene name synonym)	psi-mi:opa1_rat(display_long)|uniprotkb:Opa1(gene name)|psi-mi:Opa1(display_short)|uniprotkb:Optic atrophy protein 1 homolog(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Foster et al. (2006)	pubmed:16396496|mint:MINT-5218203	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-921030	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2711|refseq:NP_036883.1|refseq:XP_006246658.1|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007611"(learning or memory)|go:"GO:0007614"(short-term memory)|go:"GO:0007616"(long-term memory)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010021"(amylopectin biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031550"(positive regulation of brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044381"(glucose import in response to insulin stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046323"(glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0098694"(regulation of synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0098793"(presynapse)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002441("Glucose transporter, type 4 (GLUT4)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-189200|ensembl:ENSRNOG00000017226(gene)|ensembl:ENSRNOT00000023256(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)	rgd:708423|refseq:NP_598269.3|refseq:XP_006248560.1|ensembl:ENSRNOG00000001717(gene)|ensembl:ENSRNOT00000002338(transcript)|ensembl:ENSRNOT00000002343(transcript)|go:"GO:0000002"(mitochondrial genome maintenance)|go:"GO:0000266"(mitochondrial fission)|go:"GO:0001843"(neural tube closure)|go:"GO:0003374"(dynamin family protein polymerization involved in mitochondrial fission)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0007007"(inner mitochondrial membrane organization)|go:"GO:0007568"(aging)|go:"GO:0007601"(visual perception)|go:"GO:0008017"(microtubule binding)|go:"GO:0008053"(mitochondrial fusion)|go:"GO:0010636"(positive regulation of mitochondrial fusion)|go:"GO:0014042"(positive regulation of neuron maturation)|go:"GO:0014850"(response to muscle activity)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019900"(kinase binding)|go:"GO:0030061"(mitochondrial crista)|go:"GO:0030425"(dendrite)|go:"GO:0031314"(extrinsic component of mitochondrial inner membrane)|go:"GO:0031667"(response to nutrient levels)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0036444"(calcium import into the mitochondrion)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046039"(GTP metabolic process)|go:"GO:0046628"(positive regulation of insulin receptor signaling pathway)|go:"GO:0048312"(intracellular distribution of mitochondria)|go:"GO:0051259"(protein complex oligomerization)|go:"GO:0051602"(response to electrical stimulus)|go:"GO:0060041"(retina development in camera-type eye)|go:"GO:0061003"(positive regulation of dendritic spine morphogenesis)|go:"GO:0061025"(membrane fusion)|go:"GO:0070300"(phosphatidic acid binding)|go:"GO:0070584"(mitochondrion morphogenesis)|go:"GO:0071333"(cellular response to glucose stimulus)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0090102"(cochlea development)|go:"GO:0090201"(negative regulation of release of cytochrome c from mitochondria)|go:"GO:0090398"(cellular senescence)|go:"GO:0097749"(membrane tubulation)|go:"GO:1900006"(positive regulation of dendrite development)|go:"GO:1900078"(positive regulation of cellular response to insulin stimulus)|go:"GO:1901612"(cardiolipin binding)|go:"GO:1902236"(negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway)|go:"GO:1904643"(response to curcumin)|go:"GO:1905232"(cellular response to L-glutamate)|go:"GO:2001243"(negative regulation of intrinsic apoptotic signaling pathway)|interpro:IPR001401(Dynamin, GTPase region)|interpro:IPR022812|interpro:IPR027417|interpro:IPR030381|interpro:IPR033047|mint:Q2TA68|reactome:R-RNO-169911	-	-	-	caution:"The participant EBI-349571(P68370) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919386(Q7TP47) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920972(Q5XIP9) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-916419(P11980) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919578(Q8R491) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920554(Q5U3Z7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920647(Q5U2X8) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920585(Q7TP24) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-779677(P05426) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-915744(P02454) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|agonist:Insulin was shown to increase or decrease GLUT4 protein interactions in specific cases.|comment:"Insulin decreased GLUT4 interactions with the following proteins: Q9ER30 (Sarcosin), P09527 (Rab-7), O88960 (N-ethylmaleimide sensitive), P09456 (PKA I regulatory subunit), P27881 (Hexokinase type II), P07872 (Acyl-coenzyme A oxidase), Q6DGF1 (Isocitrate dehydrogenase), Q9EQX9 (Ubiquitin-conjugating), Q63446 (Polyubiquitin), P24268 (Cathepsin D), Q91XW0 (Heat shock protein 86), Q5FVH0 (unknown), P58405 (Striatin 3), Q62667 (Major vault protein), Q66H50 (unknown), Q09167 (splicing factor), Q9JHU5 (Arfaptin 1)."|comment:"Insulin increased GLUT4 interaction with the following proteins:Q9Z1P2 (R-actinin-1), P45592 (Cofilin), Q9QXQ0 (R-actinin-4), P26473 (ADP-ribosylation factor), P26437 (ADP-ribosylation factor),   Q7TNP1 (Basigin 2), Q6P6R2 (Dihydrolipoamide dehydrogenase),   P04797 (GAPDH), Q63081 (Protein disulfide isomerase), P29457 (47 kDa heat shock protein), Q9R1J8 (Leprecan), O88638 (Putative eps protein),   Q64375 (Synaptonemal complex)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:NDPK - Interactions involving proteins containing InterPro domain IPR001564, Nucleoside diphosphate kinase, core.	taxid:10116(rat-l6)|taxid:10116(Rattus norvegicus)	-	2006/02/15	2021/11/30	rogid:PbFY2lfrty8yw40Jq7ShR7xfuV410116	rogid:VoIXzPJzVZpHSJC0e6S0JpkXnYQ10116	intact-crc:44F3A2176D02515F|rigid:9RVm0UBcqQF4k06RGKO89Bg16Q8	false	myc tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P19357	uniprotkb:Q6QI88	intact:EBI-915426|uniprotkb:P97900|ensembl:ENSRNOP00000023256	intact:EBI-919231|ensembl:ENSRNOP00000000083	psi-mi:glut4_rat(display_long)|uniprotkb:Glucose transporter type 4, insulin-responsive(gene name synonym)|uniprotkb:Slc2a4(gene name)|psi-mi:Slc2a4(display_short)|uniprotkb:Glut4(gene name synonym)	psi-mi:q6qi88_rat(display_long)|uniprotkb:Tmed5(gene name)|psi-mi:Tmed5(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Foster et al. (2006)	pubmed:16396496|mint:MINT-5218203	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-921030	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2711|refseq:NP_036883.1|refseq:XP_006246658.1|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007611"(learning or memory)|go:"GO:0007614"(short-term memory)|go:"GO:0007616"(long-term memory)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010021"(amylopectin biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031550"(positive regulation of brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044381"(glucose import in response to insulin stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046323"(glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0098694"(regulation of synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0098793"(presynapse)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002441("Glucose transporter, type 4 (GLUT4)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-189200|ensembl:ENSRNOG00000017226(gene)|ensembl:ENSRNOT00000023256(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)	rgd:1359437|ensembl:ENSRNOG00000000073(gene)|ensembl:ENSRNOT00000000083(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005801"(cis-Golgi network)|go:"GO:0015031"(protein transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0033116"(endoplasmic reticulum-Golgi intermediate compartment membrane)|go:"GO:0070971"(endoplasmic reticulum exit site)|go:"GO:0090161"(Golgi ribbon formation)|interpro:IPR009038(GOLD)|interpro:IPR015717(ST2 receptor binding protein related)|interpro:IPR015720(TMP21 related)|interpro:IPR036598	-	-	-	caution:"The participant EBI-349571(P68370) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919386(Q7TP47) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920972(Q5XIP9) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-916419(P11980) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919578(Q8R491) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920554(Q5U3Z7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920647(Q5U2X8) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920585(Q7TP24) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-779677(P05426) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-915744(P02454) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|agonist:Insulin was shown to increase or decrease GLUT4 protein interactions in specific cases.|comment:"Insulin decreased GLUT4 interactions with the following proteins: Q9ER30 (Sarcosin), P09527 (Rab-7), O88960 (N-ethylmaleimide sensitive), P09456 (PKA I regulatory subunit), P27881 (Hexokinase type II), P07872 (Acyl-coenzyme A oxidase), Q6DGF1 (Isocitrate dehydrogenase), Q9EQX9 (Ubiquitin-conjugating), Q63446 (Polyubiquitin), P24268 (Cathepsin D), Q91XW0 (Heat shock protein 86), Q5FVH0 (unknown), P58405 (Striatin 3), Q62667 (Major vault protein), Q66H50 (unknown), Q09167 (splicing factor), Q9JHU5 (Arfaptin 1)."|comment:"Insulin increased GLUT4 interaction with the following proteins:Q9Z1P2 (R-actinin-1), P45592 (Cofilin), Q9QXQ0 (R-actinin-4), P26473 (ADP-ribosylation factor), P26437 (ADP-ribosylation factor),   Q7TNP1 (Basigin 2), Q6P6R2 (Dihydrolipoamide dehydrogenase),   P04797 (GAPDH), Q63081 (Protein disulfide isomerase), P29457 (47 kDa heat shock protein), Q9R1J8 (Leprecan), O88638 (Putative eps protein),   Q64375 (Synaptonemal complex)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:NDPK - Interactions involving proteins containing InterPro domain IPR001564, Nucleoside diphosphate kinase, core.	taxid:10116(rat-l6)|taxid:10116(Rattus norvegicus)	-	2006/02/15	2021/11/30	rogid:PbFY2lfrty8yw40Jq7ShR7xfuV410116	rogid:v7zzgsae4sOiCXY/gz83aPS5qqs10116	intact-crc:44F3A2176D02515F|rigid:9RVm0UBcqQF4k06RGKO89Bg16Q8	false	myc tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P19357	uniprotkb:Q6QI86	intact:EBI-915426|uniprotkb:P97900|ensembl:ENSRNOP00000023256	intact:EBI-919224|ensembl:ENSRNOP00000039553	psi-mi:glut4_rat(display_long)|uniprotkb:Glucose transporter type 4, insulin-responsive(gene name synonym)|uniprotkb:Slc2a4(gene name)|psi-mi:Slc2a4(display_short)|uniprotkb:Glut4(gene name synonym)	psi-mi:q6qi86_rat(display_long)|uniprotkb:Hdhd2(gene name)|psi-mi:Hdhd2(display_short)|uniprotkb:RGD1308579(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Foster et al. (2006)	pubmed:16396496|mint:MINT-5218203	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-921030	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2711|refseq:NP_036883.1|refseq:XP_006246658.1|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007611"(learning or memory)|go:"GO:0007614"(short-term memory)|go:"GO:0007616"(long-term memory)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010021"(amylopectin biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031550"(positive regulation of brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044381"(glucose import in response to insulin stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046323"(glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0098694"(regulation of synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0098793"(presynapse)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002441("Glucose transporter, type 4 (GLUT4)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-189200|ensembl:ENSRNOG00000017226(gene)|ensembl:ENSRNOT00000023256(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)	rgd:1308579|refseq:NP_001014173.2|ensembl:ENSRNOG00000043171(gene)|ensembl:ENSRNOT00000051857(transcript)|go:"GO:0015031"(protein transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016791"(phosphatase activity)|go:"GO:0019899"(enzyme binding)|interpro:IPR006355(HAD-superfamily hydrolase, subfamily IIA, hypothetical 2)|interpro:IPR006357(HAD-superfamily hydrolase, subfamily IIA)|interpro:IPR013880(Yos1-like)|interpro:IPR023214|interpro:IPR036412	-	-	-	caution:"The participant EBI-349571(P68370) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919386(Q7TP47) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920972(Q5XIP9) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-916419(P11980) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919578(Q8R491) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920554(Q5U3Z7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920647(Q5U2X8) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920585(Q7TP24) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-779677(P05426) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-915744(P02454) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|agonist:Insulin was shown to increase or decrease GLUT4 protein interactions in specific cases.|comment:"Insulin decreased GLUT4 interactions with the following proteins: Q9ER30 (Sarcosin), P09527 (Rab-7), O88960 (N-ethylmaleimide sensitive), P09456 (PKA I regulatory subunit), P27881 (Hexokinase type II), P07872 (Acyl-coenzyme A oxidase), Q6DGF1 (Isocitrate dehydrogenase), Q9EQX9 (Ubiquitin-conjugating), Q63446 (Polyubiquitin), P24268 (Cathepsin D), Q91XW0 (Heat shock protein 86), Q5FVH0 (unknown), P58405 (Striatin 3), Q62667 (Major vault protein), Q66H50 (unknown), Q09167 (splicing factor), Q9JHU5 (Arfaptin 1)."|comment:"Insulin increased GLUT4 interaction with the following proteins:Q9Z1P2 (R-actinin-1), P45592 (Cofilin), Q9QXQ0 (R-actinin-4), P26473 (ADP-ribosylation factor), P26437 (ADP-ribosylation factor),   Q7TNP1 (Basigin 2), Q6P6R2 (Dihydrolipoamide dehydrogenase),   P04797 (GAPDH), Q63081 (Protein disulfide isomerase), P29457 (47 kDa heat shock protein), Q9R1J8 (Leprecan), O88638 (Putative eps protein),   Q64375 (Synaptonemal complex)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:NDPK - Interactions involving proteins containing InterPro domain IPR001564, Nucleoside diphosphate kinase, core.	taxid:10116(rat-l6)|taxid:10116(Rattus norvegicus)	-	2006/02/15	2021/11/30	rogid:PbFY2lfrty8yw40Jq7ShR7xfuV410116	rogid:DQttbdVK/WE7m8r+dIzvM3DW08410116	intact-crc:44F3A2176D02515F|rigid:9RVm0UBcqQF4k06RGKO89Bg16Q8	false	myc tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P19357	uniprotkb:Q6QI16	intact:EBI-915426|uniprotkb:P97900|ensembl:ENSRNOP00000023256	intact:EBI-919221|ensembl:ENSRNOP00000070052	psi-mi:glut4_rat(display_long)|uniprotkb:Glucose transporter type 4, insulin-responsive(gene name synonym)|uniprotkb:Slc2a4(gene name)|psi-mi:Slc2a4(display_short)|uniprotkb:Glut4(gene name synonym)	psi-mi:q6qi16_rat(display_long)|uniprotkb:Rtraf(gene name)|psi-mi:Rtraf(display_short)|uniprotkb:RGD1304704(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Foster et al. (2006)	pubmed:16396496|mint:MINT-5218203	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-921030	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2711|refseq:NP_036883.1|refseq:XP_006246658.1|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007611"(learning or memory)|go:"GO:0007614"(short-term memory)|go:"GO:0007616"(long-term memory)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010021"(amylopectin biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031550"(positive regulation of brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044381"(glucose import in response to insulin stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046323"(glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0098694"(regulation of synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0098793"(presynapse)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002441("Glucose transporter, type 4 (GLUT4)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-189200|ensembl:ENSRNOG00000017226(gene)|ensembl:ENSRNOT00000023256(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)	rgd:1304704|refseq:NP_001041339.1|mint:Q6QI16|ensembl:ENSRNOG00000000340(gene)|ensembl:ENSRNOT00000092002(transcript)|go:"GO:0000993"(RNA polymerase II complex binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0006388"(tRNA splicing, via endonucleolytic cleavage and ligation)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0042802"(identical protein binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0072669"(tRNA-splicing ligase complex)|go:"GO:0072686"(mitotic spindle)|interpro:IPR019265	-	-	-	caution:"The participant EBI-349571(P68370) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919386(Q7TP47) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920972(Q5XIP9) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-916419(P11980) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919578(Q8R491) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920554(Q5U3Z7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920647(Q5U2X8) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920585(Q7TP24) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-779677(P05426) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-915744(P02454) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|agonist:Insulin was shown to increase or decrease GLUT4 protein interactions in specific cases.|comment:"Insulin decreased GLUT4 interactions with the following proteins: Q9ER30 (Sarcosin), P09527 (Rab-7), O88960 (N-ethylmaleimide sensitive), P09456 (PKA I regulatory subunit), P27881 (Hexokinase type II), P07872 (Acyl-coenzyme A oxidase), Q6DGF1 (Isocitrate dehydrogenase), Q9EQX9 (Ubiquitin-conjugating), Q63446 (Polyubiquitin), P24268 (Cathepsin D), Q91XW0 (Heat shock protein 86), Q5FVH0 (unknown), P58405 (Striatin 3), Q62667 (Major vault protein), Q66H50 (unknown), Q09167 (splicing factor), Q9JHU5 (Arfaptin 1)."|comment:"Insulin increased GLUT4 interaction with the following proteins:Q9Z1P2 (R-actinin-1), P45592 (Cofilin), Q9QXQ0 (R-actinin-4), P26473 (ADP-ribosylation factor), P26437 (ADP-ribosylation factor),   Q7TNP1 (Basigin 2), Q6P6R2 (Dihydrolipoamide dehydrogenase),   P04797 (GAPDH), Q63081 (Protein disulfide isomerase), P29457 (47 kDa heat shock protein), Q9R1J8 (Leprecan), O88638 (Putative eps protein),   Q64375 (Synaptonemal complex)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:NDPK - Interactions involving proteins containing InterPro domain IPR001564, Nucleoside diphosphate kinase, core.	taxid:10116(rat-l6)|taxid:10116(Rattus norvegicus)	-	2006/02/15	2021/11/30	rogid:PbFY2lfrty8yw40Jq7ShR7xfuV410116	rogid:gwkwk9BBszPBpJShzT/tXhbwyBQ10116	intact-crc:44F3A2176D02515F|rigid:9RVm0UBcqQF4k06RGKO89Bg16Q8	false	myc tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P19357	uniprotkb:Q6Q7Y5	intact:EBI-915426|uniprotkb:P97900|ensembl:ENSRNOP00000023256	intact:EBI-919210|ensembl:ENSRNOP00000051938	psi-mi:glut4_rat(display_long)|uniprotkb:Glucose transporter type 4, insulin-responsive(gene name synonym)|uniprotkb:Slc2a4(gene name)|psi-mi:Slc2a4(display_short)|uniprotkb:Glut4(gene name synonym)	psi-mi:gna13_rat(display_long)|uniprotkb:Gna13(gene name)|psi-mi:Gna13(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Foster et al. (2006)	pubmed:16396496|mint:MINT-5218203	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-921030	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2711|refseq:NP_036883.1|refseq:XP_006246658.1|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007611"(learning or memory)|go:"GO:0007614"(short-term memory)|go:"GO:0007616"(long-term memory)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010021"(amylopectin biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031550"(positive regulation of brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044381"(glucose import in response to insulin stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046323"(glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0098694"(regulation of synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0098793"(presynapse)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002441("Glucose transporter, type 4 (GLUT4)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-189200|ensembl:ENSRNOG00000017226(gene)|ensembl:ENSRNOT00000023256(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)	rgd:1310221|refseq:NP_001013137.1|ensembl:ENSRNOG00000036745(gene)|ensembl:ENSRNOT00000055062(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001569"(branching involved in blood vessel morphogenesis)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005834"(heterotrimeric G-protein complex)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007188"(adenylate cyclase-modulating G protein-coupled receptor signaling pathway)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007266"(Rho protein signal transduction)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0030154"(cell differentiation)|go:"GO:0030168"(platelet activation)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0031526"(brush border membrane)|go:"GO:0031584"(activation of phospholipase D activity)|go:"GO:0031683"(G-protein beta/gamma-subunit complex binding)|go:"GO:0031752"(D5 dopamine receptor binding)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042470"(melanosome)|go:"GO:0046872"(metal ion binding)|go:"GO:1904706"(negative regulation of vascular associated smooth muscle cell proliferation)|go:"GO:1904753"(negative regulation of vascular associated smooth muscle cell migration)|interpro:IPR000469(G-protein alpha subunit, group 12)|interpro:IPR001019("Guanine nucleotide binding protein (G-protein), alpha subunit")|interpro:IPR011025(G protein alpha subunit, helical insertion)|interpro:IPR027417|reactome:R-RNO-193648|reactome:R-RNO-416482|reactome:R-RNO-428930|reactome:R-RNO-9013148|reactome:R-RNO-9013149	-	-	-	caution:"The participant EBI-349571(P68370) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919386(Q7TP47) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920972(Q5XIP9) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-916419(P11980) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919578(Q8R491) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920554(Q5U3Z7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920647(Q5U2X8) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920585(Q7TP24) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-779677(P05426) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-915744(P02454) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|agonist:Insulin was shown to increase or decrease GLUT4 protein interactions in specific cases.|comment:"Insulin decreased GLUT4 interactions with the following proteins: Q9ER30 (Sarcosin), P09527 (Rab-7), O88960 (N-ethylmaleimide sensitive), P09456 (PKA I regulatory subunit), P27881 (Hexokinase type II), P07872 (Acyl-coenzyme A oxidase), Q6DGF1 (Isocitrate dehydrogenase), Q9EQX9 (Ubiquitin-conjugating), Q63446 (Polyubiquitin), P24268 (Cathepsin D), Q91XW0 (Heat shock protein 86), Q5FVH0 (unknown), P58405 (Striatin 3), Q62667 (Major vault protein), Q66H50 (unknown), Q09167 (splicing factor), Q9JHU5 (Arfaptin 1)."|comment:"Insulin increased GLUT4 interaction with the following proteins:Q9Z1P2 (R-actinin-1), P45592 (Cofilin), Q9QXQ0 (R-actinin-4), P26473 (ADP-ribosylation factor), P26437 (ADP-ribosylation factor),   Q7TNP1 (Basigin 2), Q6P6R2 (Dihydrolipoamide dehydrogenase),   P04797 (GAPDH), Q63081 (Protein disulfide isomerase), P29457 (47 kDa heat shock protein), Q9R1J8 (Leprecan), O88638 (Putative eps protein),   Q64375 (Synaptonemal complex)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:NDPK - Interactions involving proteins containing InterPro domain IPR001564, Nucleoside diphosphate kinase, core.	taxid:10116(rat-l6)|taxid:10116(Rattus norvegicus)	-	2006/02/15	2021/11/30	rogid:PbFY2lfrty8yw40Jq7ShR7xfuV410116	rogid:6QzvjeZLIpvWBSKfq8H62FD9PDQ10116	intact-crc:44F3A2176D02515F|rigid:9RVm0UBcqQF4k06RGKO89Bg16Q8	false	myc tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P19357	uniprotkb:Q6Q0N3	intact:EBI-915426|uniprotkb:P97900|ensembl:ENSRNOP00000023256	intact:EBI-919206|uniprotkb:Q5M7U9|ensembl:ENSRNOP00000024840	psi-mi:glut4_rat(display_long)|uniprotkb:Glucose transporter type 4, insulin-responsive(gene name synonym)|uniprotkb:Slc2a4(gene name)|psi-mi:Slc2a4(display_short)|uniprotkb:Glut4(gene name synonym)	psi-mi:nt5d2_rat(display_long)|uniprotkb:Nt5dc2(gene name)|psi-mi:Nt5dc2(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Foster et al. (2006)	pubmed:16396496|mint:MINT-5218203	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-921030	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2711|refseq:NP_036883.1|refseq:XP_006246658.1|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007611"(learning or memory)|go:"GO:0007614"(short-term memory)|go:"GO:0007616"(long-term memory)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010021"(amylopectin biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031550"(positive regulation of brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044381"(glucose import in response to insulin stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046323"(glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0098694"(regulation of synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0098793"(presynapse)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002441("Glucose transporter, type 4 (GLUT4)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-189200|ensembl:ENSRNOG00000017226(gene)|ensembl:ENSRNOT00000023256(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)	rgd:1305524|refseq:NP_001009271.1|ensembl:ENSRNOG00000018358(gene)|ensembl:ENSRNOT00000024840(transcript)|go:"GO:0008253"(5'-nucleotidase activity)|go:"GO:0046872"(metal ion binding)|interpro:IPR008380(HAD-superfamily hydrolase, subfamily IG, 5'-nucleotidase)|interpro:IPR016695(Purine 5'-nucleotidase)|interpro:IPR023214|interpro:IPR036412	-	-	-	caution:"The participant EBI-349571(P68370) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919386(Q7TP47) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920972(Q5XIP9) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-916419(P11980) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919578(Q8R491) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920554(Q5U3Z7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920647(Q5U2X8) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920585(Q7TP24) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-779677(P05426) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-915744(P02454) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|agonist:Insulin was shown to increase or decrease GLUT4 protein interactions in specific cases.|comment:"Insulin decreased GLUT4 interactions with the following proteins: Q9ER30 (Sarcosin), P09527 (Rab-7), O88960 (N-ethylmaleimide sensitive), P09456 (PKA I regulatory subunit), P27881 (Hexokinase type II), P07872 (Acyl-coenzyme A oxidase), Q6DGF1 (Isocitrate dehydrogenase), Q9EQX9 (Ubiquitin-conjugating), Q63446 (Polyubiquitin), P24268 (Cathepsin D), Q91XW0 (Heat shock protein 86), Q5FVH0 (unknown), P58405 (Striatin 3), Q62667 (Major vault protein), Q66H50 (unknown), Q09167 (splicing factor), Q9JHU5 (Arfaptin 1)."|comment:"Insulin increased GLUT4 interaction with the following proteins:Q9Z1P2 (R-actinin-1), P45592 (Cofilin), Q9QXQ0 (R-actinin-4), P26473 (ADP-ribosylation factor), P26437 (ADP-ribosylation factor),   Q7TNP1 (Basigin 2), Q6P6R2 (Dihydrolipoamide dehydrogenase),   P04797 (GAPDH), Q63081 (Protein disulfide isomerase), P29457 (47 kDa heat shock protein), Q9R1J8 (Leprecan), O88638 (Putative eps protein),   Q64375 (Synaptonemal complex)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:NDPK - Interactions involving proteins containing InterPro domain IPR001564, Nucleoside diphosphate kinase, core.	taxid:10116(rat-l6)|taxid:10116(Rattus norvegicus)	-	2006/02/15	2021/11/30	rogid:PbFY2lfrty8yw40Jq7ShR7xfuV410116	rogid:LtyhtaG6HfWU7OWuFTxEDNj17pM10116	intact-crc:44F3A2176D02515F|rigid:9RVm0UBcqQF4k06RGKO89Bg16Q8	false	myc tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P19357	uniprotkb:Q6PEC5	intact:EBI-915426|uniprotkb:P97900|ensembl:ENSRNOP00000023256	intact:EBI-919199	psi-mi:glut4_rat(display_long)|uniprotkb:Glucose transporter type 4, insulin-responsive(gene name synonym)|uniprotkb:Slc2a4(gene name)|psi-mi:Slc2a4(display_short)|uniprotkb:Glut4(gene name synonym)	psi-mi:q6pec5_rat(display_long)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Foster et al. (2006)	pubmed:16396496|mint:MINT-5218203	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-921030	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2711|refseq:NP_036883.1|refseq:XP_006246658.1|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007611"(learning or memory)|go:"GO:0007614"(short-term memory)|go:"GO:0007616"(long-term memory)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010021"(amylopectin biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031550"(positive regulation of brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044381"(glucose import in response to insulin stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046323"(glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0098694"(regulation of synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0098793"(presynapse)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002441("Glucose transporter, type 4 (GLUT4)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-189200|ensembl:ENSRNOG00000017226(gene)|ensembl:ENSRNOT00000023256(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)	interpro:IPR018152|interpro:IPR001424(Superoxide dismutase, copper/zinc binding)|interpro:IPR024134|interpro:IPR036423|go:"GO:0006801"(superoxide metabolic process)|go:"GO:0046872"(metal ion binding)	-	-	-	caution:"The participant EBI-349571(P68370) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919386(Q7TP47) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920972(Q5XIP9) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-916419(P11980) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919578(Q8R491) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920554(Q5U3Z7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920647(Q5U2X8) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920585(Q7TP24) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-779677(P05426) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-915744(P02454) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|agonist:Insulin was shown to increase or decrease GLUT4 protein interactions in specific cases.|comment:"Insulin decreased GLUT4 interactions with the following proteins: Q9ER30 (Sarcosin), P09527 (Rab-7), O88960 (N-ethylmaleimide sensitive), P09456 (PKA I regulatory subunit), P27881 (Hexokinase type II), P07872 (Acyl-coenzyme A oxidase), Q6DGF1 (Isocitrate dehydrogenase), Q9EQX9 (Ubiquitin-conjugating), Q63446 (Polyubiquitin), P24268 (Cathepsin D), Q91XW0 (Heat shock protein 86), Q5FVH0 (unknown), P58405 (Striatin 3), Q62667 (Major vault protein), Q66H50 (unknown), Q09167 (splicing factor), Q9JHU5 (Arfaptin 1)."|comment:"Insulin increased GLUT4 interaction with the following proteins:Q9Z1P2 (R-actinin-1), P45592 (Cofilin), Q9QXQ0 (R-actinin-4), P26473 (ADP-ribosylation factor), P26437 (ADP-ribosylation factor),   Q7TNP1 (Basigin 2), Q6P6R2 (Dihydrolipoamide dehydrogenase),   P04797 (GAPDH), Q63081 (Protein disulfide isomerase), P29457 (47 kDa heat shock protein), Q9R1J8 (Leprecan), O88638 (Putative eps protein),   Q64375 (Synaptonemal complex)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:NDPK - Interactions involving proteins containing InterPro domain IPR001564, Nucleoside diphosphate kinase, core.	taxid:10116(rat-l6)|taxid:10116(Rattus norvegicus)	-	2006/02/15	2021/11/30	rogid:PbFY2lfrty8yw40Jq7ShR7xfuV410116	rogid:WeQMJIKLwHUHamWektZdbmqCO0Q10116	intact-crc:44F3A2176D02515F|rigid:9RVm0UBcqQF4k06RGKO89Bg16Q8	false	myc tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P19357	uniprotkb:Q6PEC4	intact:EBI-915426|uniprotkb:P97900|ensembl:ENSRNOP00000023256	intact:EBI-919194|ensembl:ENSRNOP00000007676	psi-mi:glut4_rat(display_long)|uniprotkb:Glucose transporter type 4, insulin-responsive(gene name synonym)|uniprotkb:Slc2a4(gene name)|psi-mi:Slc2a4(display_short)|uniprotkb:Glut4(gene name synonym)	psi-mi:skp1_rat(display_long)|uniprotkb:Skp1(gene name)|psi-mi:Skp1(display_short)|uniprotkb:Skp1a(gene name synonym)|uniprotkb:S-phase kinase-associated protein 1A(gene name synonym)|uniprotkb:Cyclin-A/CDK2-associated protein p19(gene name synonym)|uniprotkb:p19skp1(gene name synonym)|uniprotkb:p19A(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Foster et al. (2006)	pubmed:16396496|mint:MINT-5218203	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-921030	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2711|refseq:NP_036883.1|refseq:XP_006246658.1|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007611"(learning or memory)|go:"GO:0007614"(short-term memory)|go:"GO:0007616"(long-term memory)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010021"(amylopectin biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031550"(positive regulation of brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044381"(glucose import in response to insulin stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046323"(glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0098694"(regulation of synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0098793"(presynapse)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002441("Glucose transporter, type 4 (GLUT4)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-189200|ensembl:ENSRNOG00000017226(gene)|ensembl:ENSRNOT00000023256(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)	rgd:1359648|refseq:NP_001007609.1|dip:DIP-29863N|ensembl:ENSRNOG00000005828(gene)|ensembl:ENSRNOT00000007676(transcript)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0006513"(protein monoubiquitination)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019005"(SCF ubiquitin ligase complex)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0031146"(SCF-dependent proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0031467"(Cul7-RING ubiquitin ligase complex)|go:"GO:0035518"(histone H2A monoubiquitination)|go:"GO:0051457"(maintenance of protein location in nucleus)|go:"GO:0070936"(protein K48-linked ubiquitination)|go:"GO:0097602"(cullin family protein binding)|go:"GO:1904668"(positive regulation of ubiquitin protein ligase activity)|go:"GO:1990444"(F-box domain binding)|go:"GO:1990756"(ubiquitin ligase-substrate adaptor activity)|interpro:IPR001232(SKP1 component)|interpro:IPR011333(BTB/POZ fold)|interpro:IPR016072(SKP1 component, dimerisation)|interpro:IPR016073(SKP1 component, POZ)|interpro:IPR016897(E3 ubiquitin ligase, SCF complex, Skp subunit)|interpro:IPR036296|reactome:R-RNO-1169091|reactome:R-RNO-1170546|reactome:R-RNO-187577|reactome:R-RNO-195253|reactome:R-RNO-2565942|reactome:R-RNO-5607761|reactome:R-RNO-5610780|reactome:R-RNO-5610785|reactome:R-RNO-5676590|reactome:R-RNO-68949|reactome:R-RNO-69231|reactome:R-RNO-8854050|reactome:R-RNO-8951664|reactome:R-RNO-917937|reactome:R-RNO-983168	-	-	-	caution:"The participant EBI-349571(P68370) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919386(Q7TP47) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920972(Q5XIP9) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-916419(P11980) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919578(Q8R491) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920554(Q5U3Z7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920647(Q5U2X8) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920585(Q7TP24) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-779677(P05426) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-915744(P02454) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|agonist:Insulin was shown to increase or decrease GLUT4 protein interactions in specific cases.|comment:"Insulin decreased GLUT4 interactions with the following proteins: Q9ER30 (Sarcosin), P09527 (Rab-7), O88960 (N-ethylmaleimide sensitive), P09456 (PKA I regulatory subunit), P27881 (Hexokinase type II), P07872 (Acyl-coenzyme A oxidase), Q6DGF1 (Isocitrate dehydrogenase), Q9EQX9 (Ubiquitin-conjugating), Q63446 (Polyubiquitin), P24268 (Cathepsin D), Q91XW0 (Heat shock protein 86), Q5FVH0 (unknown), P58405 (Striatin 3), Q62667 (Major vault protein), Q66H50 (unknown), Q09167 (splicing factor), Q9JHU5 (Arfaptin 1)."|comment:"Insulin increased GLUT4 interaction with the following proteins:Q9Z1P2 (R-actinin-1), P45592 (Cofilin), Q9QXQ0 (R-actinin-4), P26473 (ADP-ribosylation factor), P26437 (ADP-ribosylation factor),   Q7TNP1 (Basigin 2), Q6P6R2 (Dihydrolipoamide dehydrogenase),   P04797 (GAPDH), Q63081 (Protein disulfide isomerase), P29457 (47 kDa heat shock protein), Q9R1J8 (Leprecan), O88638 (Putative eps protein),   Q64375 (Synaptonemal complex)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:NDPK - Interactions involving proteins containing InterPro domain IPR001564, Nucleoside diphosphate kinase, core.	taxid:10116(rat-l6)|taxid:10116(Rattus norvegicus)	-	2006/02/15	2021/11/30	rogid:PbFY2lfrty8yw40Jq7ShR7xfuV410116	rogid:qGk720KMKAbBPguy2tmUOZsLxRQ10116	intact-crc:44F3A2176D02515F|rigid:9RVm0UBcqQF4k06RGKO89Bg16Q8	false	myc tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P19357	uniprotkb:Q6PDV8	intact:EBI-915426|uniprotkb:P97900|ensembl:ENSRNOP00000023256	intact:EBI-919185|uniprotkb:F7FLF2|ensembl:ENSRNOP00000014905	psi-mi:glut4_rat(display_long)|uniprotkb:Glucose transporter type 4, insulin-responsive(gene name synonym)|uniprotkb:Slc2a4(gene name)|psi-mi:Slc2a4(display_short)|uniprotkb:Glut4(gene name synonym)	psi-mi:q6pdv8_rat(display_long)|uniprotkb:LOC100363800(gene name synonym)|uniprotkb:Rpl22(gene name synonym)|uniprotkb:LOC100360057(gene name)|psi-mi:LOC100360057(display_short)|uniprotkb:rCG_31311(orf name)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Foster et al. (2006)	pubmed:16396496|mint:MINT-5218203	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-921030	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2711|refseq:NP_036883.1|refseq:XP_006246658.1|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007611"(learning or memory)|go:"GO:0007614"(short-term memory)|go:"GO:0007616"(long-term memory)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010021"(amylopectin biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031550"(positive regulation of brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044381"(glucose import in response to insulin stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046323"(glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0098694"(regulation of synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0098793"(presynapse)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002441("Glucose transporter, type 4 (GLUT4)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-189200|ensembl:ENSRNOG00000017226(gene)|ensembl:ENSRNOT00000023256(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)	rgd:2322888|rgd:621189|refseq:XP_003753964.1|refseq:XP_002729438.2|ensembl:ENSRNOG00000011104(gene)|ensembl:ENSRNOT00000014904(transcript)|go:"GO:0002181"(cytoplasmic translation)|go:"GO:0003723"(RNA binding)|go:"GO:0003735"(structural constituent of ribosome)|go:"GO:0005634"(nucleus)|go:"GO:0008201"(heparin binding)|go:"GO:0022626"(cytosolic ribosome)|go:"GO:0042802"(identical protein binding)|go:"GO:0045182"(translation regulator activity)|go:"GO:0046632"(alpha-beta T cell differentiation)|go:"GO:0098793"(presynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099577"(regulation of translation at presynapse, modulating synaptic transmission)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR002671(Ribosomal protein L22e)|interpro:IPR038526	-	-	-	caution:"The participant EBI-349571(P68370) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919386(Q7TP47) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920972(Q5XIP9) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-916419(P11980) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919578(Q8R491) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920554(Q5U3Z7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920647(Q5U2X8) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920585(Q7TP24) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-779677(P05426) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-915744(P02454) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|agonist:Insulin was shown to increase or decrease GLUT4 protein interactions in specific cases.|comment:"Insulin decreased GLUT4 interactions with the following proteins: Q9ER30 (Sarcosin), P09527 (Rab-7), O88960 (N-ethylmaleimide sensitive), P09456 (PKA I regulatory subunit), P27881 (Hexokinase type II), P07872 (Acyl-coenzyme A oxidase), Q6DGF1 (Isocitrate dehydrogenase), Q9EQX9 (Ubiquitin-conjugating), Q63446 (Polyubiquitin), P24268 (Cathepsin D), Q91XW0 (Heat shock protein 86), Q5FVH0 (unknown), P58405 (Striatin 3), Q62667 (Major vault protein), Q66H50 (unknown), Q09167 (splicing factor), Q9JHU5 (Arfaptin 1)."|comment:"Insulin increased GLUT4 interaction with the following proteins:Q9Z1P2 (R-actinin-1), P45592 (Cofilin), Q9QXQ0 (R-actinin-4), P26473 (ADP-ribosylation factor), P26437 (ADP-ribosylation factor),   Q7TNP1 (Basigin 2), Q6P6R2 (Dihydrolipoamide dehydrogenase),   P04797 (GAPDH), Q63081 (Protein disulfide isomerase), P29457 (47 kDa heat shock protein), Q9R1J8 (Leprecan), O88638 (Putative eps protein),   Q64375 (Synaptonemal complex)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:NDPK - Interactions involving proteins containing InterPro domain IPR001564, Nucleoside diphosphate kinase, core.	taxid:10116(rat-l6)|taxid:10116(Rattus norvegicus)	-	2006/02/15	2021/11/30	rogid:PbFY2lfrty8yw40Jq7ShR7xfuV410116	rogid:8YjwLFx7406UlWyCGYWpxG8sbMY10116	intact-crc:44F3A2176D02515F|rigid:9RVm0UBcqQF4k06RGKO89Bg16Q8	false	myc tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P19357	uniprotkb:Q6PDV7	intact:EBI-915426|uniprotkb:P97900|ensembl:ENSRNOP00000023256	intact:EBI-919179|uniprotkb:P45634|ensembl:ENSRNOP00000070105	psi-mi:glut4_rat(display_long)|uniprotkb:Glucose transporter type 4, insulin-responsive(gene name synonym)|uniprotkb:Slc2a4(gene name)|psi-mi:Slc2a4(display_short)|uniprotkb:Glut4(gene name synonym)	psi-mi:rl10_rat(display_long)|uniprotkb:Ribosomal protein L10(gene name synonym)|uniprotkb:Rpl10(gene name)|psi-mi:Rpl10(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Foster et al. (2006)	pubmed:16396496|mint:MINT-5218203	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-921030	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2711|refseq:NP_036883.1|refseq:XP_006246658.1|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007611"(learning or memory)|go:"GO:0007614"(short-term memory)|go:"GO:0007616"(long-term memory)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010021"(amylopectin biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031550"(positive regulation of brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044381"(glucose import in response to insulin stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046323"(glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0098694"(regulation of synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0098793"(presynapse)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002441("Glucose transporter, type 4 (GLUT4)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-189200|ensembl:ENSRNOG00000017226(gene)|ensembl:ENSRNOT00000023256(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)	rgd:621178|refseq:NP_112362.1|ensembl:ENSRNOG00000056765(gene)|ensembl:ENSRNOT00000083951(transcript)|go:"GO:0000027"(ribosomal large subunit assembly)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0003735"(structural constituent of ribosome)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005790"(smooth endoplasmic reticulum)|go:"GO:0006412"(translation)|go:"GO:0006417"(regulation of translation)|go:"GO:0022625"(cytosolic large ribosomal subunit)|go:"GO:0022626"(cytosolic ribosome)|go:"GO:0032991"(protein-containing complex)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045202"(synapse)|go:"GO:0097421"(liver regeneration)|go:"GO:1990403"(embryonic brain development)|interpro:IPR001197(Ribosomal protein L10e)|interpro:IPR016180(Ribosomal protein L10e/L16)|interpro:IPR018255|interpro:IPR036920|reactome:R-RNO-156827|reactome:R-RNO-1799339|reactome:R-RNO-6791226|reactome:R-RNO-72689|reactome:R-RNO-72706|reactome:R-RNO-975956|reactome:R-RNO-975957	-	-	-	caution:"The participant EBI-349571(P68370) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919386(Q7TP47) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920972(Q5XIP9) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-916419(P11980) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919578(Q8R491) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920554(Q5U3Z7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920647(Q5U2X8) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920585(Q7TP24) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-779677(P05426) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-915744(P02454) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|agonist:Insulin was shown to increase or decrease GLUT4 protein interactions in specific cases.|comment:"Insulin decreased GLUT4 interactions with the following proteins: Q9ER30 (Sarcosin), P09527 (Rab-7), O88960 (N-ethylmaleimide sensitive), P09456 (PKA I regulatory subunit), P27881 (Hexokinase type II), P07872 (Acyl-coenzyme A oxidase), Q6DGF1 (Isocitrate dehydrogenase), Q9EQX9 (Ubiquitin-conjugating), Q63446 (Polyubiquitin), P24268 (Cathepsin D), Q91XW0 (Heat shock protein 86), Q5FVH0 (unknown), P58405 (Striatin 3), Q62667 (Major vault protein), Q66H50 (unknown), Q09167 (splicing factor), Q9JHU5 (Arfaptin 1)."|comment:"Insulin increased GLUT4 interaction with the following proteins:Q9Z1P2 (R-actinin-1), P45592 (Cofilin), Q9QXQ0 (R-actinin-4), P26473 (ADP-ribosylation factor), P26437 (ADP-ribosylation factor),   Q7TNP1 (Basigin 2), Q6P6R2 (Dihydrolipoamide dehydrogenase),   P04797 (GAPDH), Q63081 (Protein disulfide isomerase), P29457 (47 kDa heat shock protein), Q9R1J8 (Leprecan), O88638 (Putative eps protein),   Q64375 (Synaptonemal complex)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:NDPK - Interactions involving proteins containing InterPro domain IPR001564, Nucleoside diphosphate kinase, core.	taxid:10116(rat-l6)|taxid:10116(Rattus norvegicus)	-	2006/02/15	2021/11/30	rogid:PbFY2lfrty8yw40Jq7ShR7xfuV410116	rogid:wJnBcv39yvVz2CaZq8UKgxIpJeE10116	intact-crc:44F3A2176D02515F|rigid:9RVm0UBcqQF4k06RGKO89Bg16Q8	false	myc tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P19357	uniprotkb:Q6PDV1	intact:EBI-915426|uniprotkb:P97900|ensembl:ENSRNOP00000023256	intact:EBI-919170	psi-mi:glut4_rat(display_long)|uniprotkb:Glucose transporter type 4, insulin-responsive(gene name synonym)|uniprotkb:Slc2a4(gene name)|psi-mi:Slc2a4(display_short)|uniprotkb:Glut4(gene name synonym)	psi-mi:q6pdv1_rat(display_long)|uniprotkb:Lyz2(gene name)|psi-mi:Lyz2(display_short)|uniprotkb:Lyz(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Foster et al. (2006)	pubmed:16396496|mint:MINT-5218203	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-921030	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2711|refseq:NP_036883.1|refseq:XP_006246658.1|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007611"(learning or memory)|go:"GO:0007614"(short-term memory)|go:"GO:0007616"(long-term memory)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010021"(amylopectin biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031550"(positive regulation of brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044381"(glucose import in response to insulin stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046323"(glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0098694"(regulation of synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0098793"(presynapse)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002441("Glucose transporter, type 4 (GLUT4)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-189200|ensembl:ENSRNOG00000017226(gene)|ensembl:ENSRNOT00000023256(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)	interpro:IPR023346|rgd:3026|refseq:NP_036903.2|interpro:IPR001916(Glycoside hydrolase, family 22)|interpro:IPR019799|interpro:IPR000974(Glycoside hydrolase, family 22, lysozyme)|interpro:IPR030056|go:"GO:0003796"(lysozyme activity)|go:"GO:0008152"(metabolic process)|go:"GO:0019835"(cytolysis)|go:"GO:0042742"(defense response to bacterium)	-	-	-	caution:"The participant EBI-349571(P68370) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919386(Q7TP47) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920972(Q5XIP9) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-916419(P11980) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919578(Q8R491) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920554(Q5U3Z7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920647(Q5U2X8) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920585(Q7TP24) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-779677(P05426) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-915744(P02454) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|agonist:Insulin was shown to increase or decrease GLUT4 protein interactions in specific cases.|comment:"Insulin decreased GLUT4 interactions with the following proteins: Q9ER30 (Sarcosin), P09527 (Rab-7), O88960 (N-ethylmaleimide sensitive), P09456 (PKA I regulatory subunit), P27881 (Hexokinase type II), P07872 (Acyl-coenzyme A oxidase), Q6DGF1 (Isocitrate dehydrogenase), Q9EQX9 (Ubiquitin-conjugating), Q63446 (Polyubiquitin), P24268 (Cathepsin D), Q91XW0 (Heat shock protein 86), Q5FVH0 (unknown), P58405 (Striatin 3), Q62667 (Major vault protein), Q66H50 (unknown), Q09167 (splicing factor), Q9JHU5 (Arfaptin 1)."|comment:"Insulin increased GLUT4 interaction with the following proteins:Q9Z1P2 (R-actinin-1), P45592 (Cofilin), Q9QXQ0 (R-actinin-4), P26473 (ADP-ribosylation factor), P26437 (ADP-ribosylation factor),   Q7TNP1 (Basigin 2), Q6P6R2 (Dihydrolipoamide dehydrogenase),   P04797 (GAPDH), Q63081 (Protein disulfide isomerase), P29457 (47 kDa heat shock protein), Q9R1J8 (Leprecan), O88638 (Putative eps protein),   Q64375 (Synaptonemal complex)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:NDPK - Interactions involving proteins containing InterPro domain IPR001564, Nucleoside diphosphate kinase, core.	taxid:10116(rat-l6)|taxid:10116(Rattus norvegicus)	-	2006/02/15	2021/11/30	rogid:PbFY2lfrty8yw40Jq7ShR7xfuV410116	rogid:amgHTdJQpLpM/Ny3w51OxOvDq5M10116	intact-crc:44F3A2176D02515F|rigid:9RVm0UBcqQF4k06RGKO89Bg16Q8	false	myc tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P19357	uniprotkb:Q6PCU2	intact:EBI-915426|uniprotkb:P97900|ensembl:ENSRNOP00000023256	intact:EBI-919161	psi-mi:glut4_rat(display_long)|uniprotkb:Glucose transporter type 4, insulin-responsive(gene name synonym)|uniprotkb:Slc2a4(gene name)|psi-mi:Slc2a4(display_short)|uniprotkb:Glut4(gene name synonym)	psi-mi:vate1_rat(display_long)|uniprotkb:Atp6v1e1(gene name)|psi-mi:Atp6v1e1(display_short)|uniprotkb:Vacuolar proton pump subunit E 1(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Foster et al. (2006)	pubmed:16396496|mint:MINT-5218203	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-921030	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2711|refseq:NP_036883.1|refseq:XP_006246658.1|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007611"(learning or memory)|go:"GO:0007614"(short-term memory)|go:"GO:0007616"(long-term memory)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010021"(amylopectin biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031550"(positive regulation of brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044381"(glucose import in response to insulin stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046323"(glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0098694"(regulation of synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0098793"(presynapse)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002441("Glucose transporter, type 4 (GLUT4)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-189200|ensembl:ENSRNOG00000017226(gene)|ensembl:ENSRNOT00000023256(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)	rgd:735157|refseq:NP_942040.1|interpro:IPR002842(ATPase, V1/A1 complex, subunit E)|mint:Q6PCU2|interpro:IPR038495|go:"GO:0000221"(vacuolar proton-transporting V-type ATPase, V1 domain)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005902"(microvillus)|go:"GO:0008553"(P-type proton-exporting transporter activity)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016787"(hydrolase activity)|go:"GO:0046961"(proton-transporting ATPase activity, rotational mechanism)|go:"GO:0051117"(ATPase binding)|go:"GO:1902600"(proton transmembrane transport)|rcsb pdb:6VQ6|rcsb pdb:6VQ7|rcsb pdb:6VQ8|rcsb pdb:6VQ9|rcsb pdb:6VQA|rcsb pdb:6VQB|rcsb pdb:6VQI|rcsb pdb:6VQJ|rcsb pdb:6VQK|reactome:R-RNO-1222556|reactome:R-RNO-77387|reactome:R-RNO-917977|reactome:R-RNO-9639288|reactome:R-RNO-983712	-	-	-	caution:"The participant EBI-349571(P68370) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919386(Q7TP47) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920972(Q5XIP9) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-916419(P11980) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919578(Q8R491) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920554(Q5U3Z7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920647(Q5U2X8) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920585(Q7TP24) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-779677(P05426) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-915744(P02454) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|agonist:Insulin was shown to increase or decrease GLUT4 protein interactions in specific cases.|comment:"Insulin decreased GLUT4 interactions with the following proteins: Q9ER30 (Sarcosin), P09527 (Rab-7), O88960 (N-ethylmaleimide sensitive), P09456 (PKA I regulatory subunit), P27881 (Hexokinase type II), P07872 (Acyl-coenzyme A oxidase), Q6DGF1 (Isocitrate dehydrogenase), Q9EQX9 (Ubiquitin-conjugating), Q63446 (Polyubiquitin), P24268 (Cathepsin D), Q91XW0 (Heat shock protein 86), Q5FVH0 (unknown), P58405 (Striatin 3), Q62667 (Major vault protein), Q66H50 (unknown), Q09167 (splicing factor), Q9JHU5 (Arfaptin 1)."|comment:"Insulin increased GLUT4 interaction with the following proteins:Q9Z1P2 (R-actinin-1), P45592 (Cofilin), Q9QXQ0 (R-actinin-4), P26473 (ADP-ribosylation factor), P26437 (ADP-ribosylation factor),   Q7TNP1 (Basigin 2), Q6P6R2 (Dihydrolipoamide dehydrogenase),   P04797 (GAPDH), Q63081 (Protein disulfide isomerase), P29457 (47 kDa heat shock protein), Q9R1J8 (Leprecan), O88638 (Putative eps protein),   Q64375 (Synaptonemal complex)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:NDPK - Interactions involving proteins containing InterPro domain IPR001564, Nucleoside diphosphate kinase, core.	taxid:10116(rat-l6)|taxid:10116(Rattus norvegicus)	-	2006/02/15	2021/11/30	rogid:PbFY2lfrty8yw40Jq7ShR7xfuV410116	rogid:mfYO92S6Lf0DGuQmxSaUAoCmQcw10116	intact-crc:44F3A2176D02515F|rigid:9RVm0UBcqQF4k06RGKO89Bg16Q8	false	myc tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P19357	uniprotkb:Q6PCT9	intact:EBI-915426|uniprotkb:P97900|ensembl:ENSRNOP00000023256	intact:EBI-919152|ensembl:ENSRNOP00000009249	psi-mi:glut4_rat(display_long)|uniprotkb:Glucose transporter type 4, insulin-responsive(gene name synonym)|uniprotkb:Slc2a4(gene name)|psi-mi:Slc2a4(display_short)|uniprotkb:Glut4(gene name synonym)	psi-mi:q6pct9_rat(display_long)|uniprotkb:Psmd6(gene name)|psi-mi:Psmd6(display_short)|uniprotkb:26S proteasome regulatory subunit RPN7(gene name synonym)|uniprotkb:rCG_42172(orf name)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Foster et al. (2006)	pubmed:16396496|mint:MINT-5218203	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-921030	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2711|refseq:NP_036883.1|refseq:XP_006246658.1|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007611"(learning or memory)|go:"GO:0007614"(short-term memory)|go:"GO:0007616"(long-term memory)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010021"(amylopectin biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031550"(positive regulation of brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044381"(glucose import in response to insulin stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046323"(glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0098694"(regulation of synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0098793"(presynapse)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002441("Glucose transporter, type 4 (GLUT4)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-189200|ensembl:ENSRNOG00000017226(gene)|ensembl:ENSRNOT00000023256(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)	rgd:735127|refseq:NP_942025.1|ensembl:ENSRNOG00000006751(gene)|ensembl:ENSRNOT00000009249(transcript)|go:"GO:0000502"(proteasome complex)|go:"GO:0005838"(proteasome regulatory particle)|go:"GO:0022624"(proteasome accessory complex)|go:"GO:0030234"(enzyme regulator activity)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|interpro:IPR000717(Proteasome component region PCI)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019585|interpro:IPR035268|interpro:IPR036390|rcsb pdb:6EPC|rcsb pdb:6EPD|rcsb pdb:6EPE|rcsb pdb:6EPF|reactome:R-RNO-1169091|reactome:R-RNO-1234176|reactome:R-RNO-1236978|reactome:R-RNO-174084|reactome:R-RNO-174154|reactome:R-RNO-174178|reactome:R-RNO-174184|reactome:R-RNO-187577|reactome:R-RNO-195253|reactome:R-RNO-2467813|reactome:R-RNO-349425|reactome:R-RNO-350562|reactome:R-RNO-382556|reactome:R-RNO-450408|reactome:R-RNO-4608870|reactome:R-RNO-4641257|reactome:R-RNO-4641258|reactome:R-RNO-5358346|reactome:R-RNO-5607761|reactome:R-RNO-5610780|reactome:R-RNO-5610785|reactome:R-RNO-5632684|reactome:R-RNO-5658442|reactome:R-RNO-5668541|reactome:R-RNO-5676590|reactome:R-RNO-5687128|reactome:R-RNO-5689603|reactome:R-RNO-5689880|reactome:R-RNO-6798695|reactome:R-RNO-68827|reactome:R-RNO-68949|reactome:R-RNO-69017|reactome:R-RNO-69481|reactome:R-RNO-69601|reactome:R-RNO-75815|reactome:R-RNO-8852276|reactome:R-RNO-8854050|reactome:R-RNO-8932339|reactome:R-RNO-8939236|reactome:R-RNO-8941858|reactome:R-RNO-8948751|reactome:R-RNO-8951664|reactome:R-RNO-983168	-	-	-	caution:"The participant EBI-349571(P68370) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919386(Q7TP47) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920972(Q5XIP9) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-916419(P11980) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919578(Q8R491) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920554(Q5U3Z7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920647(Q5U2X8) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920585(Q7TP24) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-779677(P05426) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-915744(P02454) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|agonist:Insulin was shown to increase or decrease GLUT4 protein interactions in specific cases.|comment:"Insulin decreased GLUT4 interactions with the following proteins: Q9ER30 (Sarcosin), P09527 (Rab-7), O88960 (N-ethylmaleimide sensitive), P09456 (PKA I regulatory subunit), P27881 (Hexokinase type II), P07872 (Acyl-coenzyme A oxidase), Q6DGF1 (Isocitrate dehydrogenase), Q9EQX9 (Ubiquitin-conjugating), Q63446 (Polyubiquitin), P24268 (Cathepsin D), Q91XW0 (Heat shock protein 86), Q5FVH0 (unknown), P58405 (Striatin 3), Q62667 (Major vault protein), Q66H50 (unknown), Q09167 (splicing factor), Q9JHU5 (Arfaptin 1)."|comment:"Insulin increased GLUT4 interaction with the following proteins:Q9Z1P2 (R-actinin-1), P45592 (Cofilin), Q9QXQ0 (R-actinin-4), P26473 (ADP-ribosylation factor), P26437 (ADP-ribosylation factor),   Q7TNP1 (Basigin 2), Q6P6R2 (Dihydrolipoamide dehydrogenase),   P04797 (GAPDH), Q63081 (Protein disulfide isomerase), P29457 (47 kDa heat shock protein), Q9R1J8 (Leprecan), O88638 (Putative eps protein),   Q64375 (Synaptonemal complex)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:NDPK - Interactions involving proteins containing InterPro domain IPR001564, Nucleoside diphosphate kinase, core.	taxid:10116(rat-l6)|taxid:10116(Rattus norvegicus)	-	2006/02/15	2021/11/30	rogid:PbFY2lfrty8yw40Jq7ShR7xfuV410116	rogid:eVII3KU7aJLNRx/HTFdmpajOw0o10116	intact-crc:44F3A2176D02515F|rigid:9RVm0UBcqQF4k06RGKO89Bg16Q8	false	myc tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P19357	uniprotkb:Q68FQ0	intact:EBI-915426|uniprotkb:P97900|ensembl:ENSRNOP00000023256	intact:EBI-931470|uniprotkb:Q6PCT4|ensembl:ENSRNOP00000015886	psi-mi:glut4_rat(display_long)|uniprotkb:Glucose transporter type 4, insulin-responsive(gene name synonym)|uniprotkb:Slc2a4(gene name)|psi-mi:Slc2a4(display_short)|uniprotkb:Glut4(gene name synonym)	psi-mi:tcpe_rat(display_long)|uniprotkb:Cct5(gene name)|psi-mi:Cct5(display_short)|uniprotkb:CCT-epsilon(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Foster et al. (2006)	pubmed:16396496|mint:MINT-5218203	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-921030	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2711|refseq:NP_036883.1|refseq:XP_006246658.1|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007611"(learning or memory)|go:"GO:0007614"(short-term memory)|go:"GO:0007616"(long-term memory)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010021"(amylopectin biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031550"(positive regulation of brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044381"(glucose import in response to insulin stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046323"(glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0098694"(regulation of synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0098793"(presynapse)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002441("Glucose transporter, type 4 (GLUT4)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-189200|ensembl:ENSRNOG00000017226(gene)|ensembl:ENSRNOT00000023256(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)	rgd:735161|refseq:NP_001004078.1|ensembl:ENSRNOG00000011632(gene)|ensembl:ENSRNOT00000015886(transcript)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005813"(centrosome)|go:"GO:0005832"(chaperonin-containing T-complex)|go:"GO:0005874"(microtubule)|go:"GO:0006457"(protein folding)|go:"GO:0007339"(binding of sperm to zona pellucida)|go:"GO:0009615"(response to virus)|go:"GO:0031681"(G-protein beta-subunit binding)|go:"GO:0032212"(positive regulation of telomere maintenance via telomerase)|go:"GO:0044183"(protein folding chaperone)|go:"GO:0044297"(cell body)|go:"GO:0048027"(mRNA 5'-UTR binding)|go:"GO:0048487"(beta-tubulin binding)|go:"GO:0050821"(protein stabilization)|go:"GO:0051082"(unfolded protein binding)|go:"GO:1901998"(toxin transport)|go:"GO:1904851"(positive regulation of establishment of protein localization to telomere)|interpro:IPR002194(Chaperonin TCP-1, conserved site)|interpro:IPR002423(Chaperonin Cpn60/TCP-1)|interpro:IPR012718(T-complex protein 1, epsilon subunit)|interpro:IPR017998|interpro:IPR027409|interpro:IPR027410|interpro:IPR027413|mint:Q68FQ0|reactome:R-RNO-390471|reactome:R-RNO-5620922|reactome:R-RNO-6814122	-	-	-	caution:"The participant EBI-349571(P68370) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919386(Q7TP47) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920972(Q5XIP9) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-916419(P11980) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919578(Q8R491) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920554(Q5U3Z7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920647(Q5U2X8) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920585(Q7TP24) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-779677(P05426) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-915744(P02454) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|agonist:Insulin was shown to increase or decrease GLUT4 protein interactions in specific cases.|comment:"Insulin decreased GLUT4 interactions with the following proteins: Q9ER30 (Sarcosin), P09527 (Rab-7), O88960 (N-ethylmaleimide sensitive), P09456 (PKA I regulatory subunit), P27881 (Hexokinase type II), P07872 (Acyl-coenzyme A oxidase), Q6DGF1 (Isocitrate dehydrogenase), Q9EQX9 (Ubiquitin-conjugating), Q63446 (Polyubiquitin), P24268 (Cathepsin D), Q91XW0 (Heat shock protein 86), Q5FVH0 (unknown), P58405 (Striatin 3), Q62667 (Major vault protein), Q66H50 (unknown), Q09167 (splicing factor), Q9JHU5 (Arfaptin 1)."|comment:"Insulin increased GLUT4 interaction with the following proteins:Q9Z1P2 (R-actinin-1), P45592 (Cofilin), Q9QXQ0 (R-actinin-4), P26473 (ADP-ribosylation factor), P26437 (ADP-ribosylation factor),   Q7TNP1 (Basigin 2), Q6P6R2 (Dihydrolipoamide dehydrogenase),   P04797 (GAPDH), Q63081 (Protein disulfide isomerase), P29457 (47 kDa heat shock protein), Q9R1J8 (Leprecan), O88638 (Putative eps protein),   Q64375 (Synaptonemal complex)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:NDPK - Interactions involving proteins containing InterPro domain IPR001564, Nucleoside diphosphate kinase, core.	taxid:10116(rat-l6)|taxid:10116(Rattus norvegicus)	-	2006/02/15	2021/11/30	rogid:PbFY2lfrty8yw40Jq7ShR7xfuV410116	rogid:ABW24Esuv9oCZYZr+++2wlVSTcI10116	intact-crc:44F3A2176D02515F|rigid:9RVm0UBcqQF4k06RGKO89Bg16Q8	false	myc tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P19357	uniprotkb:Q6P9V9	intact:EBI-915426|uniprotkb:P97900|ensembl:ENSRNOP00000023256	intact:EBI-349311|ensembl:ENSRNOP00000070868	psi-mi:glut4_rat(display_long)|uniprotkb:Glucose transporter type 4, insulin-responsive(gene name synonym)|uniprotkb:Slc2a4(gene name)|psi-mi:Slc2a4(display_short)|uniprotkb:Glut4(gene name synonym)	psi-mi:tba1b_rat(display_long)|uniprotkb:Tuba1b(gene name)|psi-mi:Tuba1b(display_short)|uniprotkb:Tubulin alpha-2 chain(gene name synonym)|uniprotkb:Alpha-tubulin 2(gene name synonym)|uniprotkb:Tuba2(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Foster et al. (2006)	pubmed:16396496|mint:MINT-5218203	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-921030	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2711|refseq:NP_036883.1|refseq:XP_006246658.1|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007611"(learning or memory)|go:"GO:0007614"(short-term memory)|go:"GO:0007616"(long-term memory)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010021"(amylopectin biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031550"(positive regulation of brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044381"(glucose import in response to insulin stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046323"(glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0098694"(regulation of synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0098793"(presynapse)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002441("Glucose transporter, type 4 (GLUT4)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-189200|ensembl:ENSRNOG00000017226(gene)|ensembl:ENSRNOT00000023256(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)	rgd:1565476|refseq:NP_001037735.1|ensembl:ENSRNOG00000053468(gene)|ensembl:ENSRNOT00000081355(transcript)|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0005200"(structural constituent of cytoskeleton)|go:"GO:0005525"(GTP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005874"(microtubule)|go:"GO:0005881"(cytoplasmic microtubule)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0045121"(membrane raft)|go:"GO:0071353"(cellular response to interleukin-4)|interpro:IPR000217(Tubulin)|interpro:IPR002452(Alpha tubulin)|interpro:IPR003008(Tubulin/FtsZ, GTPase)|interpro:IPR008280(Tubulin/FtsZ, C-terminal)|interpro:IPR017975|interpro:IPR018316|interpro:IPR036525|interpro:IPR037103|mint:Q6P9V9|reactome:R-RNO-190840|reactome:R-RNO-2132295|reactome:R-RNO-2467813|reactome:R-RNO-2500257|reactome:R-RNO-3371497|reactome:R-RNO-380320|reactome:R-RNO-437239|reactome:R-RNO-5610787|reactome:R-RNO-5617833|reactome:R-RNO-5620924|reactome:R-RNO-5626467|reactome:R-RNO-5663220|reactome:R-RNO-6807878|reactome:R-RNO-6811434|reactome:R-RNO-6811436|interpro:IPR023123|reactome:R-RNO-68877|reactome:R-RNO-8852276|reactome:R-RNO-8955332|reactome:R-RNO-9013407|reactome:R-RNO-9646399|reactome:R-RNO-9648025|reactome:R-RNO-9668328|reactome:R-RNO-983189	-	-	-	caution:"The participant EBI-349571(P68370) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919386(Q7TP47) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920972(Q5XIP9) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-916419(P11980) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919578(Q8R491) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920554(Q5U3Z7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920647(Q5U2X8) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920585(Q7TP24) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-779677(P05426) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-915744(P02454) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|agonist:Insulin was shown to increase or decrease GLUT4 protein interactions in specific cases.|comment:"Insulin decreased GLUT4 interactions with the following proteins: Q9ER30 (Sarcosin), P09527 (Rab-7), O88960 (N-ethylmaleimide sensitive), P09456 (PKA I regulatory subunit), P27881 (Hexokinase type II), P07872 (Acyl-coenzyme A oxidase), Q6DGF1 (Isocitrate dehydrogenase), Q9EQX9 (Ubiquitin-conjugating), Q63446 (Polyubiquitin), P24268 (Cathepsin D), Q91XW0 (Heat shock protein 86), Q5FVH0 (unknown), P58405 (Striatin 3), Q62667 (Major vault protein), Q66H50 (unknown), Q09167 (splicing factor), Q9JHU5 (Arfaptin 1)."|comment:"Insulin increased GLUT4 interaction with the following proteins:Q9Z1P2 (R-actinin-1), P45592 (Cofilin), Q9QXQ0 (R-actinin-4), P26473 (ADP-ribosylation factor), P26437 (ADP-ribosylation factor),   Q7TNP1 (Basigin 2), Q6P6R2 (Dihydrolipoamide dehydrogenase),   P04797 (GAPDH), Q63081 (Protein disulfide isomerase), P29457 (47 kDa heat shock protein), Q9R1J8 (Leprecan), O88638 (Putative eps protein),   Q64375 (Synaptonemal complex)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:NDPK - Interactions involving proteins containing InterPro domain IPR001564, Nucleoside diphosphate kinase, core.	taxid:10116(rat-l6)|taxid:10116(Rattus norvegicus)	-	2006/02/15	2021/11/30	rogid:PbFY2lfrty8yw40Jq7ShR7xfuV410116	rogid:D4YpuLCXl/S+53qV7P7sF81aARY10116	intact-crc:44F3A2176D02515F|rigid:9RVm0UBcqQF4k06RGKO89Bg16Q8	false	myc tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P19357	uniprotkb:Q6P9U9	intact:EBI-915426|uniprotkb:P97900|ensembl:ENSRNOP00000023256	intact:EBI-919130	psi-mi:glut4_rat(display_long)|uniprotkb:Glucose transporter type 4, insulin-responsive(gene name synonym)|uniprotkb:Slc2a4(gene name)|psi-mi:Slc2a4(display_short)|uniprotkb:Glut4(gene name synonym)	psi-mi:q6p9u9_rat(display_long)|uniprotkb:Impdh2(gene name)|psi-mi:Impdh2(display_short)|uniprotkb:IMPDH(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Foster et al. (2006)	pubmed:16396496|mint:MINT-5218203	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-921030	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2711|refseq:NP_036883.1|refseq:XP_006246658.1|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007611"(learning or memory)|go:"GO:0007614"(short-term memory)|go:"GO:0007616"(long-term memory)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010021"(amylopectin biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031550"(positive regulation of brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044381"(glucose import in response to insulin stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046323"(glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0098694"(regulation of synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0098793"(presynapse)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002441("Glucose transporter, type 4 (GLUT4)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-189200|ensembl:ENSRNOG00000017226(gene)|ensembl:ENSRNOT00000023256(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)	rgd:735092|refseq:NP_954530.1|interpro:IPR013785(Aldolase-type TIM barrel)|interpro:IPR000644(Cystathionine beta-synthase, core)|interpro:IPR005990(IMP dehydrogenase)|interpro:IPR015875(IMP dehydrogenase / GMP reductase, conserved site)|interpro:IPR001093(IMP dehydrogenase/GMP reductase)|go:"GO:0000166"(nucleotide binding)|go:"GO:0003938"(IMP dehydrogenase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006177"(GMP biosynthetic process)|go:"GO:0046872"(metal ion binding)	-	-	-	caution:"The participant EBI-349571(P68370) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919386(Q7TP47) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920972(Q5XIP9) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-916419(P11980) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919578(Q8R491) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920554(Q5U3Z7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920647(Q5U2X8) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920585(Q7TP24) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-779677(P05426) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-915744(P02454) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|agonist:Insulin was shown to increase or decrease GLUT4 protein interactions in specific cases.|comment:"Insulin decreased GLUT4 interactions with the following proteins: Q9ER30 (Sarcosin), P09527 (Rab-7), O88960 (N-ethylmaleimide sensitive), P09456 (PKA I regulatory subunit), P27881 (Hexokinase type II), P07872 (Acyl-coenzyme A oxidase), Q6DGF1 (Isocitrate dehydrogenase), Q9EQX9 (Ubiquitin-conjugating), Q63446 (Polyubiquitin), P24268 (Cathepsin D), Q91XW0 (Heat shock protein 86), Q5FVH0 (unknown), P58405 (Striatin 3), Q62667 (Major vault protein), Q66H50 (unknown), Q09167 (splicing factor), Q9JHU5 (Arfaptin 1)."|comment:"Insulin increased GLUT4 interaction with the following proteins:Q9Z1P2 (R-actinin-1), P45592 (Cofilin), Q9QXQ0 (R-actinin-4), P26473 (ADP-ribosylation factor), P26437 (ADP-ribosylation factor),   Q7TNP1 (Basigin 2), Q6P6R2 (Dihydrolipoamide dehydrogenase),   P04797 (GAPDH), Q63081 (Protein disulfide isomerase), P29457 (47 kDa heat shock protein), Q9R1J8 (Leprecan), O88638 (Putative eps protein),   Q64375 (Synaptonemal complex)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:NDPK - Interactions involving proteins containing InterPro domain IPR001564, Nucleoside diphosphate kinase, core.	taxid:10116(rat-l6)|taxid:10116(Rattus norvegicus)	-	2006/02/15	2021/11/30	rogid:PbFY2lfrty8yw40Jq7ShR7xfuV410116	rogid:UUBBAUVRR+cehxoIabYmH12JcQs10116	intact-crc:44F3A2176D02515F|rigid:9RVm0UBcqQF4k06RGKO89Bg16Q8	false	myc tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P19357	uniprotkb:Q6P9U3	intact:EBI-915426|uniprotkb:P97900|ensembl:ENSRNOP00000023256	intact:EBI-919123|ensembl:ENSRNOP00000022201	psi-mi:glut4_rat(display_long)|uniprotkb:Glucose transporter type 4, insulin-responsive(gene name synonym)|uniprotkb:Slc2a4(gene name)|psi-mi:Slc2a4(display_short)|uniprotkb:Glut4(gene name synonym)	psi-mi:comd3_rat(display_long)|uniprotkb:Commd3(gene name)|psi-mi:Commd3(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Foster et al. (2006)	pubmed:16396496|mint:MINT-5218203	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-921030	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2711|refseq:NP_036883.1|refseq:XP_006246658.1|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007611"(learning or memory)|go:"GO:0007614"(short-term memory)|go:"GO:0007616"(long-term memory)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010021"(amylopectin biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031550"(positive regulation of brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044381"(glucose import in response to insulin stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046323"(glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0098694"(regulation of synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0098793"(presynapse)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002441("Glucose transporter, type 4 (GLUT4)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-189200|ensembl:ENSRNOG00000017226(gene)|ensembl:ENSRNOT00000023256(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)	rgd:735116|refseq:NP_942027.1|ensembl:ENSRNOG00000016383(gene)|ensembl:ENSRNOT00000022201(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006814"(sodium ion transport)|interpro:IPR017920|interpro:IPR037355|reactome:R-RNO-6798695|reactome:R-RNO-8951664	-	-	-	caution:"The participant EBI-349571(P68370) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919386(Q7TP47) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920972(Q5XIP9) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-916419(P11980) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919578(Q8R491) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920554(Q5U3Z7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920647(Q5U2X8) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920585(Q7TP24) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-779677(P05426) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-915744(P02454) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|agonist:Insulin was shown to increase or decrease GLUT4 protein interactions in specific cases.|comment:"Insulin decreased GLUT4 interactions with the following proteins: Q9ER30 (Sarcosin), P09527 (Rab-7), O88960 (N-ethylmaleimide sensitive), P09456 (PKA I regulatory subunit), P27881 (Hexokinase type II), P07872 (Acyl-coenzyme A oxidase), Q6DGF1 (Isocitrate dehydrogenase), Q9EQX9 (Ubiquitin-conjugating), Q63446 (Polyubiquitin), P24268 (Cathepsin D), Q91XW0 (Heat shock protein 86), Q5FVH0 (unknown), P58405 (Striatin 3), Q62667 (Major vault protein), Q66H50 (unknown), Q09167 (splicing factor), Q9JHU5 (Arfaptin 1)."|comment:"Insulin increased GLUT4 interaction with the following proteins:Q9Z1P2 (R-actinin-1), P45592 (Cofilin), Q9QXQ0 (R-actinin-4), P26473 (ADP-ribosylation factor), P26437 (ADP-ribosylation factor),   Q7TNP1 (Basigin 2), Q6P6R2 (Dihydrolipoamide dehydrogenase),   P04797 (GAPDH), Q63081 (Protein disulfide isomerase), P29457 (47 kDa heat shock protein), Q9R1J8 (Leprecan), O88638 (Putative eps protein),   Q64375 (Synaptonemal complex)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:NDPK - Interactions involving proteins containing InterPro domain IPR001564, Nucleoside diphosphate kinase, core.	taxid:10116(rat-l6)|taxid:10116(Rattus norvegicus)	-	2006/02/15	2021/11/30	rogid:PbFY2lfrty8yw40Jq7ShR7xfuV410116	rogid:FOoxDn8JdUX/7NhJ6MVzF+qoxqQ10116	intact-crc:44F3A2176D02515F|rigid:9RVm0UBcqQF4k06RGKO89Bg16Q8	false	myc tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P19357	uniprotkb:Q6P9U0	intact:EBI-915426|uniprotkb:P97900|ensembl:ENSRNOP00000023256	intact:EBI-919117|ensembl:ENSRNOP00000024161	psi-mi:glut4_rat(display_long)|uniprotkb:Glucose transporter type 4, insulin-responsive(gene name synonym)|uniprotkb:Slc2a4(gene name)|psi-mi:Slc2a4(display_short)|uniprotkb:Glut4(gene name synonym)	psi-mi:q6p9u0_rat(display_long)|uniprotkb:Serpinb6a(gene name)|psi-mi:Serpinb6a(display_short)|uniprotkb:Serpinb6(gene name synonym)|uniprotkb:rCG_44079(orf name)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Foster et al. (2006)	pubmed:16396496|mint:MINT-5218203	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-921030	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2711|refseq:NP_036883.1|refseq:XP_006246658.1|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007611"(learning or memory)|go:"GO:0007614"(short-term memory)|go:"GO:0007616"(long-term memory)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010021"(amylopectin biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031550"(positive regulation of brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044381"(glucose import in response to insulin stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046323"(glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0098694"(regulation of synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0098793"(presynapse)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002441("Glucose transporter, type 4 (GLUT4)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-189200|ensembl:ENSRNOG00000017226(gene)|ensembl:ENSRNOT00000023256(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)	rgd:735108|refseq:NP_954516.1|refseq:XP_008769818.1|refseq:XP_006253931.1|refseq:XP_006253932.1|ensembl:ENSRNOG00000017962(gene)|ensembl:ENSRNOT00000024161(transcript)|go:"GO:0002020"(protease binding)|go:"GO:0004867"(serine-type endopeptidase inhibitor activity)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0010951"(negative regulation of endopeptidase activity)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0097180"(serine protease inhibitor complex)|interpro:IPR000215(Protease inhibitor I4, serpin)|interpro:IPR023795|interpro:IPR023796|interpro:IPR036186|interpro:IPR042178|interpro:IPR042185|reactome:R-RNO-6798695|reactome:R-RNO-75205	-	-	-	caution:"The participant EBI-349571(P68370) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919386(Q7TP47) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920972(Q5XIP9) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-916419(P11980) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919578(Q8R491) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920554(Q5U3Z7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920647(Q5U2X8) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920585(Q7TP24) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-779677(P05426) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-915744(P02454) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|agonist:Insulin was shown to increase or decrease GLUT4 protein interactions in specific cases.|comment:"Insulin decreased GLUT4 interactions with the following proteins: Q9ER30 (Sarcosin), P09527 (Rab-7), O88960 (N-ethylmaleimide sensitive), P09456 (PKA I regulatory subunit), P27881 (Hexokinase type II), P07872 (Acyl-coenzyme A oxidase), Q6DGF1 (Isocitrate dehydrogenase), Q9EQX9 (Ubiquitin-conjugating), Q63446 (Polyubiquitin), P24268 (Cathepsin D), Q91XW0 (Heat shock protein 86), Q5FVH0 (unknown), P58405 (Striatin 3), Q62667 (Major vault protein), Q66H50 (unknown), Q09167 (splicing factor), Q9JHU5 (Arfaptin 1)."|comment:"Insulin increased GLUT4 interaction with the following proteins:Q9Z1P2 (R-actinin-1), P45592 (Cofilin), Q9QXQ0 (R-actinin-4), P26473 (ADP-ribosylation factor), P26437 (ADP-ribosylation factor),   Q7TNP1 (Basigin 2), Q6P6R2 (Dihydrolipoamide dehydrogenase),   P04797 (GAPDH), Q63081 (Protein disulfide isomerase), P29457 (47 kDa heat shock protein), Q9R1J8 (Leprecan), O88638 (Putative eps protein),   Q64375 (Synaptonemal complex)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:NDPK - Interactions involving proteins containing InterPro domain IPR001564, Nucleoside diphosphate kinase, core.	taxid:10116(rat-l6)|taxid:10116(Rattus norvegicus)	-	2006/02/15	2021/11/30	rogid:PbFY2lfrty8yw40Jq7ShR7xfuV410116	rogid:GgIIJDsPCUUp27Z//sJmitlMuQ410116	intact-crc:44F3A2176D02515F|rigid:9RVm0UBcqQF4k06RGKO89Bg16Q8	false	myc tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P19357	uniprotkb:Q6P9T8	intact:EBI-915426|uniprotkb:P97900|ensembl:ENSRNOP00000023256	intact:EBI-919099	psi-mi:glut4_rat(display_long)|uniprotkb:Glucose transporter type 4, insulin-responsive(gene name synonym)|uniprotkb:Slc2a4(gene name)|psi-mi:Slc2a4(display_short)|uniprotkb:Glut4(gene name synonym)	psi-mi:tbb4b_rat(display_long)|uniprotkb:Tubb4b(gene name)|psi-mi:Tubb4b(display_short)|uniprotkb:Tubb2c(gene name synonym)|uniprotkb:Tubulin beta-2C chain(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Foster et al. (2006)	pubmed:16396496|mint:MINT-5218203	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-921030	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2711|refseq:NP_036883.1|refseq:XP_006246658.1|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007611"(learning or memory)|go:"GO:0007614"(short-term memory)|go:"GO:0007616"(long-term memory)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010021"(amylopectin biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031550"(positive regulation of brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044381"(glucose import in response to insulin stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046323"(glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0098694"(regulation of synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0098793"(presynapse)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002441("Glucose transporter, type 4 (GLUT4)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-189200|ensembl:ENSRNOG00000017226(gene)|ensembl:ENSRNOT00000023256(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)	interpro:IPR008280(Tubulin/FtsZ, C-terminal)|interpro:IPR000217(Tubulin)|interpro:IPR018316|interpro:IPR017975|interpro:IPR003008(Tubulin/FtsZ, GTPase)|rgd:735101|refseq:NP_954525.1|interpro:IPR013838(Beta tubulin, autoregulation binding site)|interpro:IPR002453(Beta tubulin)|interpro:IPR023123|mint:Q6P9T8|interpro:IPR036525|interpro:IPR037103|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0005200"(structural constituent of cytoskeleton)|go:"GO:0005525"(GTP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005874"(microtubule)|reactome:R-RNO-190840|reactome:R-RNO-2132295|reactome:R-RNO-2467813|reactome:R-RNO-2500257|reactome:R-RNO-2565942|reactome:R-RNO-3371497|reactome:R-RNO-380259|reactome:R-RNO-380270|reactome:R-RNO-380284|reactome:R-RNO-380320|reactome:R-RNO-437239|reactome:R-RNO-5610787|reactome:R-RNO-5617833|reactome:R-RNO-5620912|reactome:R-RNO-5620924|reactome:R-RNO-5626467|reactome:R-RNO-5663220|reactome:R-RNO-6798695|reactome:R-RNO-6807878|reactome:R-RNO-6811434|reactome:R-RNO-6811436|reactome:R-RNO-68877|reactome:R-RNO-8852276|reactome:R-RNO-8854518|reactome:R-RNO-8955332|reactome:R-RNO-9646399|reactome:R-RNO-9648025|reactome:R-RNO-9668328|reactome:R-RNO-983189	-	-	-	caution:"The participant EBI-349571(P68370) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919386(Q7TP47) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920972(Q5XIP9) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-916419(P11980) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919578(Q8R491) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920554(Q5U3Z7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920647(Q5U2X8) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920585(Q7TP24) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-779677(P05426) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-915744(P02454) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|agonist:Insulin was shown to increase or decrease GLUT4 protein interactions in specific cases.|comment:"Insulin decreased GLUT4 interactions with the following proteins: Q9ER30 (Sarcosin), P09527 (Rab-7), O88960 (N-ethylmaleimide sensitive), P09456 (PKA I regulatory subunit), P27881 (Hexokinase type II), P07872 (Acyl-coenzyme A oxidase), Q6DGF1 (Isocitrate dehydrogenase), Q9EQX9 (Ubiquitin-conjugating), Q63446 (Polyubiquitin), P24268 (Cathepsin D), Q91XW0 (Heat shock protein 86), Q5FVH0 (unknown), P58405 (Striatin 3), Q62667 (Major vault protein), Q66H50 (unknown), Q09167 (splicing factor), Q9JHU5 (Arfaptin 1)."|comment:"Insulin increased GLUT4 interaction with the following proteins:Q9Z1P2 (R-actinin-1), P45592 (Cofilin), Q9QXQ0 (R-actinin-4), P26473 (ADP-ribosylation factor), P26437 (ADP-ribosylation factor),   Q7TNP1 (Basigin 2), Q6P6R2 (Dihydrolipoamide dehydrogenase),   P04797 (GAPDH), Q63081 (Protein disulfide isomerase), P29457 (47 kDa heat shock protein), Q9R1J8 (Leprecan), O88638 (Putative eps protein),   Q64375 (Synaptonemal complex)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:NDPK - Interactions involving proteins containing InterPro domain IPR001564, Nucleoside diphosphate kinase, core.	taxid:10116(rat-l6)|taxid:10116(Rattus norvegicus)	-	2006/02/15	2021/11/30	rogid:PbFY2lfrty8yw40Jq7ShR7xfuV410116	rogid:1RJgLTml+eflSvmnOyLoI1pFFTc10116	intact-crc:44F3A2176D02515F|rigid:9RVm0UBcqQF4k06RGKO89Bg16Q8	false	myc tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P19357	uniprotkb:Q6P7A9	intact:EBI-915426|uniprotkb:P97900|ensembl:ENSRNOP00000023256	intact:EBI-919091	psi-mi:glut4_rat(display_long)|uniprotkb:Glucose transporter type 4, insulin-responsive(gene name synonym)|uniprotkb:Slc2a4(gene name)|psi-mi:Slc2a4(display_short)|uniprotkb:Glut4(gene name synonym)	psi-mi:lyag_rat(display_long)|uniprotkb:Gaa(gene name)|psi-mi:Gaa(display_short)|uniprotkb:Acid maltase(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Foster et al. (2006)	pubmed:16396496|mint:MINT-5218203	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-921030	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2711|refseq:NP_036883.1|refseq:XP_006246658.1|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007611"(learning or memory)|go:"GO:0007614"(short-term memory)|go:"GO:0007616"(long-term memory)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010021"(amylopectin biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031550"(positive regulation of brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044381"(glucose import in response to insulin stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046323"(glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0098694"(regulation of synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0098793"(presynapse)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002441("Glucose transporter, type 4 (GLUT4)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-189200|ensembl:ENSRNOG00000017226(gene)|ensembl:ENSRNOT00000023256(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)	rgd:735227|refseq:NP_954549.1|interpro:IPR011013(Glycoside hydrolase-type carbohydrate-binding)|interpro:IPR000322(Glycoside hydrolase, family 31)|interpro:IPR017853(Glycoside hydrolase, catalytic core)|interpro:IPR000519(P-type trefoil)|interpro:IPR017957|interpro:IPR030458|interpro:IPR030459|interpro:IPR031727|interpro:IPR025887|interpro:IPR013780(Glycosyl hydrolase, family 13, all-beta)|reactome:R-RNO-6798695|reactome:R-RNO-70221|go:"GO:0002026"(regulation of the force of heart contraction)|go:"GO:0002086"(diaphragm contraction)|go:"GO:0003007"(heart morphogenesis)|go:"GO:0004553"(hydrolase activity, hydrolyzing O-glycosyl compounds)|go:"GO:0004558"(alpha-1,4-glucosidase activity)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005977"(glycogen metabolic process)|go:"GO:0005980"(glycogen catabolic process)|go:"GO:0006941"(striated muscle contraction)|go:"GO:0007040"(lysosome organization)|go:"GO:0007626"(locomotory behavior)|go:"GO:0009888"(tissue development)|go:"GO:0016020"(membrane)|go:"GO:0030246"(carbohydrate binding)|go:"GO:0032450"(maltose alpha-glucosidase activity)|go:"GO:0043181"(vacuolar sequestering)|go:"GO:0046716"(muscle cell cellular homeostasis)|go:"GO:0050884"(neuromuscular process controlling posture)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0060048"(cardiac muscle contraction)	-	-	-	caution:"The participant EBI-349571(P68370) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919386(Q7TP47) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920972(Q5XIP9) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-916419(P11980) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919578(Q8R491) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920554(Q5U3Z7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920647(Q5U2X8) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920585(Q7TP24) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-779677(P05426) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-915744(P02454) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|agonist:Insulin was shown to increase or decrease GLUT4 protein interactions in specific cases.|comment:"Insulin decreased GLUT4 interactions with the following proteins: Q9ER30 (Sarcosin), P09527 (Rab-7), O88960 (N-ethylmaleimide sensitive), P09456 (PKA I regulatory subunit), P27881 (Hexokinase type II), P07872 (Acyl-coenzyme A oxidase), Q6DGF1 (Isocitrate dehydrogenase), Q9EQX9 (Ubiquitin-conjugating), Q63446 (Polyubiquitin), P24268 (Cathepsin D), Q91XW0 (Heat shock protein 86), Q5FVH0 (unknown), P58405 (Striatin 3), Q62667 (Major vault protein), Q66H50 (unknown), Q09167 (splicing factor), Q9JHU5 (Arfaptin 1)."|comment:"Insulin increased GLUT4 interaction with the following proteins:Q9Z1P2 (R-actinin-1), P45592 (Cofilin), Q9QXQ0 (R-actinin-4), P26473 (ADP-ribosylation factor), P26437 (ADP-ribosylation factor),   Q7TNP1 (Basigin 2), Q6P6R2 (Dihydrolipoamide dehydrogenase),   P04797 (GAPDH), Q63081 (Protein disulfide isomerase), P29457 (47 kDa heat shock protein), Q9R1J8 (Leprecan), O88638 (Putative eps protein),   Q64375 (Synaptonemal complex)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:NDPK - Interactions involving proteins containing InterPro domain IPR001564, Nucleoside diphosphate kinase, core.	taxid:10116(rat-l6)|taxid:10116(Rattus norvegicus)	-	2006/02/15	2021/11/30	rogid:PbFY2lfrty8yw40Jq7ShR7xfuV410116	rogid:yU6Bg44PtH/BokOGdHhUtbUW7Hg10116	intact-crc:44F3A2176D02515F|rigid:9RVm0UBcqQF4k06RGKO89Bg16Q8	false	myc tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P19357	uniprotkb:Q6P799	intact:EBI-915426|uniprotkb:P97900|ensembl:ENSRNOP00000023256	intact:EBI-919078|uniprotkb:Q8CIQ8|ensembl:ENSRNOP00000038448	psi-mi:glut4_rat(display_long)|uniprotkb:Glucose transporter type 4, insulin-responsive(gene name synonym)|uniprotkb:Slc2a4(gene name)|psi-mi:Slc2a4(display_short)|uniprotkb:Glut4(gene name synonym)	psi-mi:sysc_rat(display_long)|uniprotkb:"Seryl-tRNA(Ser/Sec) synthetase"(gene name synonym)|uniprotkb:Sars1(gene name)|psi-mi:Sars1(display_short)|uniprotkb:Sars(gene name synonym)|uniprotkb:Seryl-tRNA synthetase(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Foster et al. (2006)	pubmed:16396496|mint:MINT-5218203	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-921030	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2711|refseq:NP_036883.1|refseq:XP_006246658.1|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007611"(learning or memory)|go:"GO:0007614"(short-term memory)|go:"GO:0007616"(long-term memory)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010021"(amylopectin biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031550"(positive regulation of brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044381"(glucose import in response to insulin stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046323"(glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0098694"(regulation of synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0098793"(presynapse)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002441("Glucose transporter, type 4 (GLUT4)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-189200|ensembl:ENSRNOG00000017226(gene)|ensembl:ENSRNOT00000023256(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)	rgd:628813|refseq:NP_001007607.1|ensembl:ENSRNOG00000020255(gene)|ensembl:ENSRNOT00000033015(transcript)|go:"GO:0000049"(tRNA binding)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0004828"(serine-tRNA ligase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006434"(seryl-tRNA aminoacylation)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0019899"(enzyme binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0097056"("selenocysteinyl-tRNA(Sec) biosynthetic process")|go:"GO:1904046"(negative regulation of vascular endothelial growth factor production)|interpro:IPR002314("Aminoacyl-tRNA synthetase, class II (G, H, P and S)")|interpro:IPR002317(Seryl-tRNA synthetase, class IIa)|interpro:IPR006195(Aminoacyl-tRNA synthetase, class II)|interpro:IPR010978(tRNA-binding arm)|interpro:IPR015866(Seryl-tRNA synthetase, class IIa, N-terminal)|interpro:IPR033729|interpro:IPR042103|mint:Q6P799	-	-	-	caution:"The participant EBI-349571(P68370) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919386(Q7TP47) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920972(Q5XIP9) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-916419(P11980) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919578(Q8R491) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920554(Q5U3Z7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920647(Q5U2X8) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920585(Q7TP24) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-779677(P05426) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-915744(P02454) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|agonist:Insulin was shown to increase or decrease GLUT4 protein interactions in specific cases.|comment:"Insulin decreased GLUT4 interactions with the following proteins: Q9ER30 (Sarcosin), P09527 (Rab-7), O88960 (N-ethylmaleimide sensitive), P09456 (PKA I regulatory subunit), P27881 (Hexokinase type II), P07872 (Acyl-coenzyme A oxidase), Q6DGF1 (Isocitrate dehydrogenase), Q9EQX9 (Ubiquitin-conjugating), Q63446 (Polyubiquitin), P24268 (Cathepsin D), Q91XW0 (Heat shock protein 86), Q5FVH0 (unknown), P58405 (Striatin 3), Q62667 (Major vault protein), Q66H50 (unknown), Q09167 (splicing factor), Q9JHU5 (Arfaptin 1)."|comment:"Insulin increased GLUT4 interaction with the following proteins:Q9Z1P2 (R-actinin-1), P45592 (Cofilin), Q9QXQ0 (R-actinin-4), P26473 (ADP-ribosylation factor), P26437 (ADP-ribosylation factor),   Q7TNP1 (Basigin 2), Q6P6R2 (Dihydrolipoamide dehydrogenase),   P04797 (GAPDH), Q63081 (Protein disulfide isomerase), P29457 (47 kDa heat shock protein), Q9R1J8 (Leprecan), O88638 (Putative eps protein),   Q64375 (Synaptonemal complex)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:NDPK - Interactions involving proteins containing InterPro domain IPR001564, Nucleoside diphosphate kinase, core.	taxid:10116(rat-l6)|taxid:10116(Rattus norvegicus)	-	2006/02/15	2021/11/30	rogid:PbFY2lfrty8yw40Jq7ShR7xfuV410116	rogid:eymWUFnZjGiLbirYSKsCTky8BXk10116	intact-crc:44F3A2176D02515F|rigid:9RVm0UBcqQF4k06RGKO89Bg16Q8	false	myc tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P19357	uniprotkb:Q6P792	intact:EBI-915426|uniprotkb:P97900|ensembl:ENSRNOP00000023256	intact:EBI-919071|ensembl:ENSRNOP00000049677	psi-mi:glut4_rat(display_long)|uniprotkb:Glucose transporter type 4, insulin-responsive(gene name synonym)|uniprotkb:Slc2a4(gene name)|psi-mi:Slc2a4(display_short)|uniprotkb:Glut4(gene name synonym)	psi-mi:q6p792_rat(display_long)|uniprotkb:Fhl1(gene name)|psi-mi:Fhl1(display_short)|uniprotkb:rCG_39239(orf name)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Foster et al. (2006)	pubmed:16396496|mint:MINT-5218203	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-921030	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2711|refseq:NP_036883.1|refseq:XP_006246658.1|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007611"(learning or memory)|go:"GO:0007614"(short-term memory)|go:"GO:0007616"(long-term memory)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010021"(amylopectin biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031550"(positive regulation of brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044381"(glucose import in response to insulin stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046323"(glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0098694"(regulation of synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0098793"(presynapse)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002441("Glucose transporter, type 4 (GLUT4)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-189200|ensembl:ENSRNOG00000017226(gene)|ensembl:ENSRNOT00000023256(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)	refseq:NP_001258128.1|refseq:NP_001258129.1|refseq:NP_001258130.1|refseq:NP_663702.1|rgd:2615|refseq:NP_001029098.1|ensembl:ENSRNOG00000000875(gene)|ensembl:ENSRNOT00000043820(transcript)|go:"GO:0007517"(muscle organ development)|go:"GO:0046872"(metal ion binding)|interpro:IPR001781(Zinc finger, LIM-type)|interpro:IPR042997	-	-	-	caution:"The participant EBI-349571(P68370) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919386(Q7TP47) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920972(Q5XIP9) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-916419(P11980) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919578(Q8R491) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920554(Q5U3Z7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920647(Q5U2X8) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920585(Q7TP24) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-779677(P05426) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-915744(P02454) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|agonist:Insulin was shown to increase or decrease GLUT4 protein interactions in specific cases.|comment:"Insulin decreased GLUT4 interactions with the following proteins: Q9ER30 (Sarcosin), P09527 (Rab-7), O88960 (N-ethylmaleimide sensitive), P09456 (PKA I regulatory subunit), P27881 (Hexokinase type II), P07872 (Acyl-coenzyme A oxidase), Q6DGF1 (Isocitrate dehydrogenase), Q9EQX9 (Ubiquitin-conjugating), Q63446 (Polyubiquitin), P24268 (Cathepsin D), Q91XW0 (Heat shock protein 86), Q5FVH0 (unknown), P58405 (Striatin 3), Q62667 (Major vault protein), Q66H50 (unknown), Q09167 (splicing factor), Q9JHU5 (Arfaptin 1)."|comment:"Insulin increased GLUT4 interaction with the following proteins:Q9Z1P2 (R-actinin-1), P45592 (Cofilin), Q9QXQ0 (R-actinin-4), P26473 (ADP-ribosylation factor), P26437 (ADP-ribosylation factor),   Q7TNP1 (Basigin 2), Q6P6R2 (Dihydrolipoamide dehydrogenase),   P04797 (GAPDH), Q63081 (Protein disulfide isomerase), P29457 (47 kDa heat shock protein), Q9R1J8 (Leprecan), O88638 (Putative eps protein),   Q64375 (Synaptonemal complex)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:NDPK - Interactions involving proteins containing InterPro domain IPR001564, Nucleoside diphosphate kinase, core.	taxid:10116(rat-l6)|taxid:10116(Rattus norvegicus)	-	2006/02/15	2021/11/30	rogid:PbFY2lfrty8yw40Jq7ShR7xfuV410116	rogid:LZjZc2FybEPSZ8eJjO60+Es0Z+I10116	intact-crc:44F3A2176D02515F|rigid:9RVm0UBcqQF4k06RGKO89Bg16Q8	false	myc tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P19357	uniprotkb:Q6P791	intact:EBI-915426|uniprotkb:P97900|ensembl:ENSRNOP00000023256	intact:EBI-919067|ensembl:ENSRNOP00000027150	psi-mi:glut4_rat(display_long)|uniprotkb:Glucose transporter type 4, insulin-responsive(gene name synonym)|uniprotkb:Slc2a4(gene name)|psi-mi:Slc2a4(display_short)|uniprotkb:Glut4(gene name synonym)	psi-mi:ltor1_rat(display_long)|uniprotkb:Late endosomal/lysosomal adaptor and MAPK and MTOR activator 1(gene name synonym)|uniprotkb:Lamtor1(gene name)|psi-mi:Lamtor1(display_short)|uniprotkb:Lipid raft adaptor protein p18(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Foster et al. (2006)	pubmed:16396496|mint:MINT-5218203	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-921030	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2711|refseq:NP_036883.1|refseq:XP_006246658.1|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007611"(learning or memory)|go:"GO:0007614"(short-term memory)|go:"GO:0007616"(long-term memory)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010021"(amylopectin biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031550"(positive regulation of brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044381"(glucose import in response to insulin stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046323"(glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0098694"(regulation of synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0098793"(presynapse)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002441("Glucose transporter, type 4 (GLUT4)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-189200|ensembl:ENSRNOG00000017226(gene)|ensembl:ENSRNOT00000023256(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)	rgd:735078|refseq:NP_954533.1|refseq:XP_002727613.1|refseq:XP_002730282.1|ensembl:ENSRNOG00000020016(gene)|ensembl:ENSRNOT00000027150(transcript)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0001919"(regulation of receptor recycling)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0007032"(endosome organization)|go:"GO:0007040"(lysosome organization)|go:"GO:0010872"(regulation of cholesterol esterification)|go:"GO:0010874"(regulation of cholesterol efflux)|go:"GO:0016197"(endosomal transport)|go:"GO:0031902"(late endosome membrane)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0032418"(lysosome localization)|go:"GO:0034613"(cellular protein localization)|go:"GO:0042632"(cholesterol homeostasis)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0045121"(membrane raft)|go:"GO:0051020"(GTPase binding)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0060620"(regulation of cholesterol import)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071986"(Ragulator complex)|interpro:IPR028209|mint:Q6P791|reactome:R-RNO-1632852|reactome:R-RNO-165159|reactome:R-RNO-166208|reactome:R-RNO-380972|reactome:R-RNO-5628897|reactome:R-RNO-6798695|reactome:R-RNO-8943724|reactome:R-RNO-9013148|reactome:R-RNO-9013149|reactome:R-RNO-9013404|reactome:R-RNO-9013406|reactome:R-RNO-9013407|reactome:R-RNO-9013408|reactome:R-RNO-9013423|reactome:R-RNO-9639288	-	-	-	caution:"The participant EBI-349571(P68370) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919386(Q7TP47) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920972(Q5XIP9) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-916419(P11980) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919578(Q8R491) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920554(Q5U3Z7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920647(Q5U2X8) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920585(Q7TP24) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-779677(P05426) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-915744(P02454) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|agonist:Insulin was shown to increase or decrease GLUT4 protein interactions in specific cases.|comment:"Insulin decreased GLUT4 interactions with the following proteins: Q9ER30 (Sarcosin), P09527 (Rab-7), O88960 (N-ethylmaleimide sensitive), P09456 (PKA I regulatory subunit), P27881 (Hexokinase type II), P07872 (Acyl-coenzyme A oxidase), Q6DGF1 (Isocitrate dehydrogenase), Q9EQX9 (Ubiquitin-conjugating), Q63446 (Polyubiquitin), P24268 (Cathepsin D), Q91XW0 (Heat shock protein 86), Q5FVH0 (unknown), P58405 (Striatin 3), Q62667 (Major vault protein), Q66H50 (unknown), Q09167 (splicing factor), Q9JHU5 (Arfaptin 1)."|comment:"Insulin increased GLUT4 interaction with the following proteins:Q9Z1P2 (R-actinin-1), P45592 (Cofilin), Q9QXQ0 (R-actinin-4), P26473 (ADP-ribosylation factor), P26437 (ADP-ribosylation factor),   Q7TNP1 (Basigin 2), Q6P6R2 (Dihydrolipoamide dehydrogenase),   P04797 (GAPDH), Q63081 (Protein disulfide isomerase), P29457 (47 kDa heat shock protein), Q9R1J8 (Leprecan), O88638 (Putative eps protein),   Q64375 (Synaptonemal complex)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:NDPK - Interactions involving proteins containing InterPro domain IPR001564, Nucleoside diphosphate kinase, core.	taxid:10116(rat-l6)|taxid:10116(Rattus norvegicus)	-	2006/02/15	2021/11/30	rogid:PbFY2lfrty8yw40Jq7ShR7xfuV410116	rogid:8Gt3iY+CVRjgbbq22A3DAfmgmiE10116	intact-crc:44F3A2176D02515F|rigid:9RVm0UBcqQF4k06RGKO89Bg16Q8	false	myc tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P19357	uniprotkb:Q9QXQ0	intact:EBI-915426|uniprotkb:P97900|ensembl:ENSRNOP00000023256	intact:EBI-919056|intact:EBI-923355|uniprotkb:Q6P786|ensembl:ENSRNOP00000027773	psi-mi:glut4_rat(display_long)|uniprotkb:Glucose transporter type 4, insulin-responsive(gene name synonym)|uniprotkb:Slc2a4(gene name)|psi-mi:Slc2a4(display_short)|uniprotkb:Glut4(gene name synonym)	psi-mi:actn4_rat(display_long)|uniprotkb:Actn4(gene name)|psi-mi:Actn4(display_short)|uniprotkb:Non-muscle alpha-actinin 4(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Foster et al. (2006)	pubmed:16396496|mint:MINT-5218203	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-921030	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2711|refseq:NP_036883.1|refseq:XP_006246658.1|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007611"(learning or memory)|go:"GO:0007614"(short-term memory)|go:"GO:0007616"(long-term memory)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010021"(amylopectin biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031550"(positive regulation of brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044381"(glucose import in response to insulin stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046323"(glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0098694"(regulation of synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0098793"(presynapse)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002441("Glucose transporter, type 4 (GLUT4)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-189200|ensembl:ENSRNOG00000017226(gene)|ensembl:ENSRNOT00000023256(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)	rgd:61816|refseq:NP_113863.2|ensembl:ENSRNOG00000020433(gene)|ensembl:ENSRNOT00000027773(transcript)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001725"(stress fiber)|go:"GO:0001882"(nucleoside binding)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005911"(cell-cell junction)|go:"GO:0015031"(protein transport)|go:"GO:0016922"(nuclear receptor binding)|go:"GO:0030018"(Z disc)|go:"GO:0030050"(vesicle transport along actin filament)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030374"(nuclear receptor coactivator activity)|go:"GO:0030863"(cortical cytoskeleton)|go:"GO:0031143"(pseudopodium)|go:"GO:0031490"(chromatin DNA binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0035357"(peroxisome proliferator activated receptor signaling pathway)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042974"(retinoic acid receptor binding)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043005"(neuron projection)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048384"(retinoic acid receptor signaling pathway)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048549"(positive regulation of pinocytosis)|go:"GO:0051015"(actin filament binding)|go:"GO:0051017"(actin filament bundle assembly)|go:"GO:0051271"(negative regulation of cellular component movement)|go:"GO:0051272"(positive regulation of cellular component movement)|go:"GO:0070830"(bicellular tight junction assembly)|go:"GO:1900025"(negative regulation of substrate adhesion-dependent cell spreading)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:1902396"(protein localization to bicellular tight junction)|go:"GO:1903506"(regulation of nucleic acid-templated transcription)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR001589(Actinin-type, actin-binding, conserved site)|interpro:IPR001715(Calponin-like actin-binding)|interpro:IPR002017(Spectrin repeat)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR011992(EF-Hand type)|interpro:IPR014837(EF-hand, Ca insensitive)|interpro:IPR018159|interpro:IPR018247|interpro:IPR036872|mint:Q9QXQ0|reactome:R-RNO-114608	-	-	-	caution:"The participant EBI-349571(P68370) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919386(Q7TP47) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920972(Q5XIP9) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-916419(P11980) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919578(Q8R491) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920554(Q5U3Z7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920647(Q5U2X8) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920585(Q7TP24) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-779677(P05426) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-915744(P02454) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|agonist:Insulin was shown to increase or decrease GLUT4 protein interactions in specific cases.|comment:"Insulin decreased GLUT4 interactions with the following proteins: Q9ER30 (Sarcosin), P09527 (Rab-7), O88960 (N-ethylmaleimide sensitive), P09456 (PKA I regulatory subunit), P27881 (Hexokinase type II), P07872 (Acyl-coenzyme A oxidase), Q6DGF1 (Isocitrate dehydrogenase), Q9EQX9 (Ubiquitin-conjugating), Q63446 (Polyubiquitin), P24268 (Cathepsin D), Q91XW0 (Heat shock protein 86), Q5FVH0 (unknown), P58405 (Striatin 3), Q62667 (Major vault protein), Q66H50 (unknown), Q09167 (splicing factor), Q9JHU5 (Arfaptin 1)."|comment:"Insulin increased GLUT4 interaction with the following proteins:Q9Z1P2 (R-actinin-1), P45592 (Cofilin), Q9QXQ0 (R-actinin-4), P26473 (ADP-ribosylation factor), P26437 (ADP-ribosylation factor),   Q7TNP1 (Basigin 2), Q6P6R2 (Dihydrolipoamide dehydrogenase),   P04797 (GAPDH), Q63081 (Protein disulfide isomerase), P29457 (47 kDa heat shock protein), Q9R1J8 (Leprecan), O88638 (Putative eps protein),   Q64375 (Synaptonemal complex)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:NDPK - Interactions involving proteins containing InterPro domain IPR001564, Nucleoside diphosphate kinase, core.	taxid:10116(rat-l6)|taxid:10116(Rattus norvegicus)	-	2006/02/15	2021/11/30	rogid:PbFY2lfrty8yw40Jq7ShR7xfuV410116	rogid:YdccQ9ahYoMqOKiNEbj5GgoXX0E10116	intact-crc:44F3A2176D02515F|rigid:9RVm0UBcqQF4k06RGKO89Bg16Q8	false	myc tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P19357	uniprotkb:Q6P777	intact:EBI-915426|uniprotkb:P97900|ensembl:ENSRNOP00000023256	intact:EBI-919052|ensembl:ENSRNOP00000024413	psi-mi:glut4_rat(display_long)|uniprotkb:Glucose transporter type 4, insulin-responsive(gene name synonym)|uniprotkb:Slc2a4(gene name)|psi-mi:Slc2a4(display_short)|uniprotkb:Glut4(gene name synonym)	psi-mi:mb12a_rat(display_long)|uniprotkb:Mvb12a(gene name)|psi-mi:Mvb12a(display_short)|uniprotkb:ESCRT-I complex subunit MVB12A(gene name synonym)|uniprotkb:Fam125a(gene name synonym)|uniprotkb:Protein FAM125A(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Foster et al. (2006)	pubmed:16396496|mint:MINT-5218203	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-921030	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2711|refseq:NP_036883.1|refseq:XP_006246658.1|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007611"(learning or memory)|go:"GO:0007614"(short-term memory)|go:"GO:0007616"(long-term memory)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010021"(amylopectin biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031550"(positive regulation of brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044381"(glucose import in response to insulin stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046323"(glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0098694"(regulation of synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0098793"(presynapse)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002441("Glucose transporter, type 4 (GLUT4)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-189200|ensembl:ENSRNOG00000017226(gene)|ensembl:ENSRNOT00000023256(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)	rgd:735220|refseq:NP_955407.1|ensembl:ENSRNOG00000017949(gene)|ensembl:ENSRNOT00000024413(transcript)|go:"GO:0000813"(ESCRT I complex)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0008289"(lipid binding)|go:"GO:0015031"(protein transport)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019075"(virus maturation)|go:"GO:0031902"(late endosome membrane)|go:"GO:0031982"(vesicle)|go:"GO:0032510"(endosome to lysosome transport via multivesicular body sorting pathway)|go:"GO:0032801"(receptor catabolic process)|go:"GO:0042058"(regulation of epidermal growth factor receptor signaling pathway)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0046755"(viral budding)|interpro:IPR018798|interpro:IPR023340|interpro:IPR023341|interpro:IPR040335|reactome:R-RNO-917729	-	-	-	caution:"The participant EBI-349571(P68370) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919386(Q7TP47) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920972(Q5XIP9) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-916419(P11980) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919578(Q8R491) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920554(Q5U3Z7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920647(Q5U2X8) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920585(Q7TP24) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-779677(P05426) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-915744(P02454) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|agonist:Insulin was shown to increase or decrease GLUT4 protein interactions in specific cases.|comment:"Insulin decreased GLUT4 interactions with the following proteins: Q9ER30 (Sarcosin), P09527 (Rab-7), O88960 (N-ethylmaleimide sensitive), P09456 (PKA I regulatory subunit), P27881 (Hexokinase type II), P07872 (Acyl-coenzyme A oxidase), Q6DGF1 (Isocitrate dehydrogenase), Q9EQX9 (Ubiquitin-conjugating), Q63446 (Polyubiquitin), P24268 (Cathepsin D), Q91XW0 (Heat shock protein 86), Q5FVH0 (unknown), P58405 (Striatin 3), Q62667 (Major vault protein), Q66H50 (unknown), Q09167 (splicing factor), Q9JHU5 (Arfaptin 1)."|comment:"Insulin increased GLUT4 interaction with the following proteins:Q9Z1P2 (R-actinin-1), P45592 (Cofilin), Q9QXQ0 (R-actinin-4), P26473 (ADP-ribosylation factor), P26437 (ADP-ribosylation factor),   Q7TNP1 (Basigin 2), Q6P6R2 (Dihydrolipoamide dehydrogenase),   P04797 (GAPDH), Q63081 (Protein disulfide isomerase), P29457 (47 kDa heat shock protein), Q9R1J8 (Leprecan), O88638 (Putative eps protein),   Q64375 (Synaptonemal complex)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:NDPK - Interactions involving proteins containing InterPro domain IPR001564, Nucleoside diphosphate kinase, core.	taxid:10116(rat-l6)|taxid:10116(Rattus norvegicus)	-	2006/02/15	2021/11/30	rogid:PbFY2lfrty8yw40Jq7ShR7xfuV410116	rogid:8yzAi9tlumQpDlHY8K3/Y7vxYSw10116	intact-crc:44F3A2176D02515F|rigid:9RVm0UBcqQF4k06RGKO89Bg16Q8	false	myc tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P19357	uniprotkb:Q6P762	intact:EBI-915426|uniprotkb:P97900|ensembl:ENSRNOP00000023256	intact:EBI-919041|ensembl:ENSRNOP00000030766	psi-mi:glut4_rat(display_long)|uniprotkb:Glucose transporter type 4, insulin-responsive(gene name synonym)|uniprotkb:Slc2a4(gene name)|psi-mi:Slc2a4(display_short)|uniprotkb:Glut4(gene name synonym)	psi-mi:q6p762_rat(display_long)|uniprotkb:Man2b1(gene name)|psi-mi:Man2b1(display_short)|uniprotkb:rCG_51515(orf name)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Foster et al. (2006)	pubmed:16396496|mint:MINT-5218203	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-921030	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2711|refseq:NP_036883.1|refseq:XP_006246658.1|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007611"(learning or memory)|go:"GO:0007614"(short-term memory)|go:"GO:0007616"(long-term memory)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010021"(amylopectin biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031550"(positive regulation of brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044381"(glucose import in response to insulin stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046323"(glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0098694"(regulation of synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0098793"(presynapse)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002441("Glucose transporter, type 4 (GLUT4)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-189200|ensembl:ENSRNOG00000017226(gene)|ensembl:ENSRNOT00000023256(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)	rgd:3039|refseq:NP_955436.1|ensembl:ENSRNOG00000023910(gene)|ensembl:ENSRNOT00000037699(transcript)|go:"GO:0004559"(alpha-mannosidase activity)|go:"GO:0005537"(mannose binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005764"(lysosome)|go:"GO:0005774"(vacuolar membrane)|go:"GO:0006013"(mannose metabolic process)|go:"GO:0006464"(cellular protein modification process)|go:"GO:0007611"(learning or memory)|go:"GO:0046872"(metal ion binding)|interpro:IPR000602(Glycoside hydrolase, family 38, core)|interpro:IPR011013(Glycoside hydrolase-type carbohydrate-binding)|interpro:IPR011330(Glycoside hydrolase/deacetylase, beta/alpha-barrel)|interpro:IPR011682(Glycosyl hydrolases 38, C-terminal)|interpro:IPR013780(Glycosyl hydrolase, family 13, all-beta)|interpro:IPR015341(Glycoside hydrolase, family 38, central region)|interpro:IPR027291|interpro:IPR028995|interpro:IPR037094|interpro:IPR041147|reactome:R-RNO-6798695|reactome:R-RNO-8853383	-	-	-	caution:"The participant EBI-349571(P68370) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919386(Q7TP47) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920972(Q5XIP9) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-916419(P11980) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919578(Q8R491) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920554(Q5U3Z7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920647(Q5U2X8) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920585(Q7TP24) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-779677(P05426) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-915744(P02454) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|agonist:Insulin was shown to increase or decrease GLUT4 protein interactions in specific cases.|comment:"Insulin decreased GLUT4 interactions with the following proteins: Q9ER30 (Sarcosin), P09527 (Rab-7), O88960 (N-ethylmaleimide sensitive), P09456 (PKA I regulatory subunit), P27881 (Hexokinase type II), P07872 (Acyl-coenzyme A oxidase), Q6DGF1 (Isocitrate dehydrogenase), Q9EQX9 (Ubiquitin-conjugating), Q63446 (Polyubiquitin), P24268 (Cathepsin D), Q91XW0 (Heat shock protein 86), Q5FVH0 (unknown), P58405 (Striatin 3), Q62667 (Major vault protein), Q66H50 (unknown), Q09167 (splicing factor), Q9JHU5 (Arfaptin 1)."|comment:"Insulin increased GLUT4 interaction with the following proteins:Q9Z1P2 (R-actinin-1), P45592 (Cofilin), Q9QXQ0 (R-actinin-4), P26473 (ADP-ribosylation factor), P26437 (ADP-ribosylation factor),   Q7TNP1 (Basigin 2), Q6P6R2 (Dihydrolipoamide dehydrogenase),   P04797 (GAPDH), Q63081 (Protein disulfide isomerase), P29457 (47 kDa heat shock protein), Q9R1J8 (Leprecan), O88638 (Putative eps protein),   Q64375 (Synaptonemal complex)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:NDPK - Interactions involving proteins containing InterPro domain IPR001564, Nucleoside diphosphate kinase, core.	taxid:10116(rat-l6)|taxid:10116(Rattus norvegicus)	-	2006/02/15	2021/11/30	rogid:PbFY2lfrty8yw40Jq7ShR7xfuV410116	rogid:S6+5BuBIprEWJ1t4h+bhbO3JZX410116	intact-crc:44F3A2176D02515F|rigid:9RVm0UBcqQF4k06RGKO89Bg16Q8	false	myc tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P19357	uniprotkb:Q6P6W6	intact:EBI-915426|uniprotkb:P97900|ensembl:ENSRNOP00000023256	intact:EBI-919033	psi-mi:glut4_rat(display_long)|uniprotkb:Glucose transporter type 4, insulin-responsive(gene name synonym)|uniprotkb:Slc2a4(gene name)|psi-mi:Slc2a4(display_short)|uniprotkb:Glut4(gene name synonym)	psi-mi:q6p6w6_rat(display_long)|uniprotkb:Ndufa10(gene name)|psi-mi:Ndufa10(display_short)|uniprotkb:rCG_55630(orf name)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Foster et al. (2006)	pubmed:16396496|mint:MINT-5218203	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-921030	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2711|refseq:NP_036883.1|refseq:XP_006246658.1|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007611"(learning or memory)|go:"GO:0007614"(short-term memory)|go:"GO:0007616"(long-term memory)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010021"(amylopectin biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031550"(positive regulation of brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044381"(glucose import in response to insulin stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046323"(glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0098694"(regulation of synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0098793"(presynapse)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002441("Glucose transporter, type 4 (GLUT4)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-189200|ensembl:ENSRNOG00000017226(gene)|ensembl:ENSRNOT00000023256(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)	interpro:IPR015828(NADH-ubiquinone oxidoreductase, 42 kDa subunit)|rgd:727968|refseq:NP_955789.2|interpro:IPR031314|interpro:IPR027417|go:"GO:0005747"(mitochondrial respiratory chain complex I)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0006120"(mitochondrial electron transport, NADH to ubiquinone)	-	-	-	caution:"The participant EBI-349571(P68370) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919386(Q7TP47) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920972(Q5XIP9) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-916419(P11980) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919578(Q8R491) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920554(Q5U3Z7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920647(Q5U2X8) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920585(Q7TP24) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-779677(P05426) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-915744(P02454) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|agonist:Insulin was shown to increase or decrease GLUT4 protein interactions in specific cases.|comment:"Insulin decreased GLUT4 interactions with the following proteins: Q9ER30 (Sarcosin), P09527 (Rab-7), O88960 (N-ethylmaleimide sensitive), P09456 (PKA I regulatory subunit), P27881 (Hexokinase type II), P07872 (Acyl-coenzyme A oxidase), Q6DGF1 (Isocitrate dehydrogenase), Q9EQX9 (Ubiquitin-conjugating), Q63446 (Polyubiquitin), P24268 (Cathepsin D), Q91XW0 (Heat shock protein 86), Q5FVH0 (unknown), P58405 (Striatin 3), Q62667 (Major vault protein), Q66H50 (unknown), Q09167 (splicing factor), Q9JHU5 (Arfaptin 1)."|comment:"Insulin increased GLUT4 interaction with the following proteins:Q9Z1P2 (R-actinin-1), P45592 (Cofilin), Q9QXQ0 (R-actinin-4), P26473 (ADP-ribosylation factor), P26437 (ADP-ribosylation factor),   Q7TNP1 (Basigin 2), Q6P6R2 (Dihydrolipoamide dehydrogenase),   P04797 (GAPDH), Q63081 (Protein disulfide isomerase), P29457 (47 kDa heat shock protein), Q9R1J8 (Leprecan), O88638 (Putative eps protein),   Q64375 (Synaptonemal complex)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:NDPK - Interactions involving proteins containing InterPro domain IPR001564, Nucleoside diphosphate kinase, core.	taxid:10116(rat-l6)|taxid:10116(Rattus norvegicus)	-	2006/02/15	2021/11/30	rogid:PbFY2lfrty8yw40Jq7ShR7xfuV410116	rogid:N1R0IXsaSrBKM8+VrhchIbHpsZg10116	intact-crc:44F3A2176D02515F|rigid:9RVm0UBcqQF4k06RGKO89Bg16Q8	false	myc tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P19357	uniprotkb:Q6P6V8	intact:EBI-915426|uniprotkb:P97900|ensembl:ENSRNOP00000023256	intact:EBI-919023	psi-mi:glut4_rat(display_long)|uniprotkb:Glucose transporter type 4, insulin-responsive(gene name synonym)|uniprotkb:Slc2a4(gene name)|psi-mi:Slc2a4(display_short)|uniprotkb:Glut4(gene name synonym)	psi-mi:q6p6v8_rat(display_long)|uniprotkb:Mybph(gene name)|psi-mi:Mybph(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Foster et al. (2006)	pubmed:16396496|mint:MINT-5218203	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-921030	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2711|refseq:NP_036883.1|refseq:XP_006246658.1|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007611"(learning or memory)|go:"GO:0007614"(short-term memory)|go:"GO:0007616"(long-term memory)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010021"(amylopectin biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031550"(positive regulation of brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044381"(glucose import in response to insulin stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046323"(glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0098694"(regulation of synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0098793"(presynapse)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002441("Glucose transporter, type 4 (GLUT4)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-189200|ensembl:ENSRNOG00000017226(gene)|ensembl:ENSRNOT00000023256(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)	interpro:IPR003961(Fibronectin, type III)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR036116|interpro:IPR036179	-	-	-	caution:"The participant EBI-349571(P68370) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919386(Q7TP47) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920972(Q5XIP9) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-916419(P11980) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919578(Q8R491) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920554(Q5U3Z7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920647(Q5U2X8) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920585(Q7TP24) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-779677(P05426) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-915744(P02454) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|agonist:Insulin was shown to increase or decrease GLUT4 protein interactions in specific cases.|comment:"Insulin decreased GLUT4 interactions with the following proteins: Q9ER30 (Sarcosin), P09527 (Rab-7), O88960 (N-ethylmaleimide sensitive), P09456 (PKA I regulatory subunit), P27881 (Hexokinase type II), P07872 (Acyl-coenzyme A oxidase), Q6DGF1 (Isocitrate dehydrogenase), Q9EQX9 (Ubiquitin-conjugating), Q63446 (Polyubiquitin), P24268 (Cathepsin D), Q91XW0 (Heat shock protein 86), Q5FVH0 (unknown), P58405 (Striatin 3), Q62667 (Major vault protein), Q66H50 (unknown), Q09167 (splicing factor), Q9JHU5 (Arfaptin 1)."|comment:"Insulin increased GLUT4 interaction with the following proteins:Q9Z1P2 (R-actinin-1), P45592 (Cofilin), Q9QXQ0 (R-actinin-4), P26473 (ADP-ribosylation factor), P26437 (ADP-ribosylation factor),   Q7TNP1 (Basigin 2), Q6P6R2 (Dihydrolipoamide dehydrogenase),   P04797 (GAPDH), Q63081 (Protein disulfide isomerase), P29457 (47 kDa heat shock protein), Q9R1J8 (Leprecan), O88638 (Putative eps protein),   Q64375 (Synaptonemal complex)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:NDPK - Interactions involving proteins containing InterPro domain IPR001564, Nucleoside diphosphate kinase, core.	taxid:10116(rat-l6)|taxid:10116(Rattus norvegicus)	-	2006/02/15	2021/11/30	rogid:PbFY2lfrty8yw40Jq7ShR7xfuV410116	rogid:CFaXEaSN+bP88lkbPWJesCPM+9I10116	intact-crc:44F3A2176D02515F|rigid:9RVm0UBcqQF4k06RGKO89Bg16Q8	false	myc tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P19357	uniprotkb:Q9ES53	intact:EBI-915426|uniprotkb:P97900|ensembl:ENSRNOP00000023256	intact:EBI-399031|ensembl:ENSRNOP00000067081	psi-mi:glut4_rat(display_long)|uniprotkb:Glucose transporter type 4, insulin-responsive(gene name synonym)|uniprotkb:Slc2a4(gene name)|psi-mi:Slc2a4(display_short)|uniprotkb:Glut4(gene name synonym)	psi-mi:ufd1_rat(display_long)|uniprotkb:Ufd1(gene name)|psi-mi:Ufd1(display_short)|uniprotkb:Ubiquitin fusion degradation protein 1 homolog(gene name synonym)|uniprotkb:Ufd1l(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Foster et al. (2006)	pubmed:16396496|mint:MINT-5218203	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-921030	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2711|refseq:NP_036883.1|refseq:XP_006246658.1|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007611"(learning or memory)|go:"GO:0007614"(short-term memory)|go:"GO:0007616"(long-term memory)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010021"(amylopectin biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031550"(positive regulation of brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044381"(glucose import in response to insulin stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046323"(glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0098694"(regulation of synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0098793"(presynapse)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002441("Glucose transporter, type 4 (GLUT4)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-189200|ensembl:ENSRNOG00000017226(gene)|ensembl:ENSRNOT00000023256(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)	rgd:619822|refseq:NP_445870.1|ensembl:ENSRNOG00000047394(gene)|ensembl:ENSRNOT00000071493(transcript)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0030970"(retrograde protein transport, ER to cytosol)|go:"GO:0031593"(polyubiquitin modification-dependent protein binding)|go:"GO:0032480"(negative regulation of type I interferon production)|go:"GO:0034098"(VCP-NPL4-UFD1 AAA ATPase complex)|go:"GO:0036435"(K48-linked polyubiquitin modification-dependent protein binding)|go:"GO:0036501"(UFD1-NPL4 complex)|go:"GO:0039536"(negative regulation of RIG-I signaling pathway)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0051117"(ATPase binding)|go:"GO:0071712"(ER-associated misfolded protein catabolic process)|interpro:IPR004854(Ubiquitin fusion degradation protein UFD1)|interpro:IPR042299|mint:Q9ES53|reactome:R-RNO-110320|reactome:R-RNO-5689880	-	-	-	caution:"The participant EBI-349571(P68370) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919386(Q7TP47) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920972(Q5XIP9) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-916419(P11980) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919578(Q8R491) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920554(Q5U3Z7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920647(Q5U2X8) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920585(Q7TP24) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-779677(P05426) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-915744(P02454) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|agonist:Insulin was shown to increase or decrease GLUT4 protein interactions in specific cases.|comment:"Insulin decreased GLUT4 interactions with the following proteins: Q9ER30 (Sarcosin), P09527 (Rab-7), O88960 (N-ethylmaleimide sensitive), P09456 (PKA I regulatory subunit), P27881 (Hexokinase type II), P07872 (Acyl-coenzyme A oxidase), Q6DGF1 (Isocitrate dehydrogenase), Q9EQX9 (Ubiquitin-conjugating), Q63446 (Polyubiquitin), P24268 (Cathepsin D), Q91XW0 (Heat shock protein 86), Q5FVH0 (unknown), P58405 (Striatin 3), Q62667 (Major vault protein), Q66H50 (unknown), Q09167 (splicing factor), Q9JHU5 (Arfaptin 1)."|comment:"Insulin increased GLUT4 interaction with the following proteins:Q9Z1P2 (R-actinin-1), P45592 (Cofilin), Q9QXQ0 (R-actinin-4), P26473 (ADP-ribosylation factor), P26437 (ADP-ribosylation factor),   Q7TNP1 (Basigin 2), Q6P6R2 (Dihydrolipoamide dehydrogenase),   P04797 (GAPDH), Q63081 (Protein disulfide isomerase), P29457 (47 kDa heat shock protein), Q9R1J8 (Leprecan), O88638 (Putative eps protein),   Q64375 (Synaptonemal complex)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:NDPK - Interactions involving proteins containing InterPro domain IPR001564, Nucleoside diphosphate kinase, core.	taxid:10116(rat-l6)|taxid:10116(Rattus norvegicus)	-	2006/02/15	2021/11/30	rogid:PbFY2lfrty8yw40Jq7ShR7xfuV410116	rogid:MSXnU0eOVJAvVsOfrP/Bn+jA/vM10116	intact-crc:44F3A2176D02515F|rigid:9RVm0UBcqQF4k06RGKO89Bg16Q8	false	myc tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P19357	uniprotkb:Q9ER34	intact:EBI-915426|uniprotkb:P97900|ensembl:ENSRNOP00000023256	intact:EBI-919008|uniprotkb:Q6P6V3|ensembl:ENSRNOP00000029144	psi-mi:glut4_rat(display_long)|uniprotkb:Glucose transporter type 4, insulin-responsive(gene name synonym)|uniprotkb:Slc2a4(gene name)|psi-mi:Slc2a4(display_short)|uniprotkb:Glut4(gene name synonym)	psi-mi:acon_rat(display_long)|uniprotkb:Aco2(gene name)|psi-mi:Aco2(display_short)|uniprotkb:Citrate hydro-lyase(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Foster et al. (2006)	pubmed:16396496|mint:MINT-5218203	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-921030	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2711|refseq:NP_036883.1|refseq:XP_006246658.1|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007611"(learning or memory)|go:"GO:0007614"(short-term memory)|go:"GO:0007616"(long-term memory)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010021"(amylopectin biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031550"(positive regulation of brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044381"(glucose import in response to insulin stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046323"(glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0098694"(regulation of synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0098793"(presynapse)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002441("Glucose transporter, type 4 (GLUT4)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-189200|ensembl:ENSRNOG00000017226(gene)|ensembl:ENSRNOT00000023256(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)	rgd:621360|refseq:NP_077374.2|ensembl:ENSRNOG00000024128(gene)|ensembl:ENSRNOT00000038612(transcript)|go:"GO:0001889"(liver development)|go:"GO:0003994"(aconitate hydratase activity)|go:"GO:0005506"(iron ion binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006099"(tricarboxylic acid cycle)|go:"GO:0006101"(citrate metabolic process)|go:"GO:0006102"(isocitrate metabolic process)|go:"GO:0035900"(response to isolation stress)|go:"GO:0047780"(citrate dehydratase activity)|go:"GO:0051538"(3 iron, 4 sulfur cluster binding)|go:"GO:0051539"(4 iron, 4 sulfur cluster binding)|interpro:IPR000573(Aconitase A/isopropylmalate dehydratase small subunit, swivel)|interpro:IPR001030(Aconitase/3-isopropylmalate dehydratase large subunit, alpha/beta/alpha)|interpro:IPR006248(Aconitase, mitochondrial-like)|interpro:IPR015928(Aconitase/3-isopropylmalate dehydratase, swivel)|interpro:IPR015931(Aconitase/3-isopropylmalate dehydratase large subunit, alpha/beta/alpha, subdomains 1 and 3)|interpro:IPR015932(Aconitase/3-isopropylmalate dehydratase large subunit, alpha/beta/alpha, subdomain 2)|interpro:IPR018136|interpro:IPR036008|mint:Q9ER34|reactome:R-RNO-71403	-	-	-	caution:"The participant EBI-349571(P68370) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919386(Q7TP47) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920972(Q5XIP9) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-916419(P11980) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919578(Q8R491) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920554(Q5U3Z7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920647(Q5U2X8) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920585(Q7TP24) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-779677(P05426) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-915744(P02454) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|agonist:Insulin was shown to increase or decrease GLUT4 protein interactions in specific cases.|comment:"Insulin decreased GLUT4 interactions with the following proteins: Q9ER30 (Sarcosin), P09527 (Rab-7), O88960 (N-ethylmaleimide sensitive), P09456 (PKA I regulatory subunit), P27881 (Hexokinase type II), P07872 (Acyl-coenzyme A oxidase), Q6DGF1 (Isocitrate dehydrogenase), Q9EQX9 (Ubiquitin-conjugating), Q63446 (Polyubiquitin), P24268 (Cathepsin D), Q91XW0 (Heat shock protein 86), Q5FVH0 (unknown), P58405 (Striatin 3), Q62667 (Major vault protein), Q66H50 (unknown), Q09167 (splicing factor), Q9JHU5 (Arfaptin 1)."|comment:"Insulin increased GLUT4 interaction with the following proteins:Q9Z1P2 (R-actinin-1), P45592 (Cofilin), Q9QXQ0 (R-actinin-4), P26473 (ADP-ribosylation factor), P26437 (ADP-ribosylation factor),   Q7TNP1 (Basigin 2), Q6P6R2 (Dihydrolipoamide dehydrogenase),   P04797 (GAPDH), Q63081 (Protein disulfide isomerase), P29457 (47 kDa heat shock protein), Q9R1J8 (Leprecan), O88638 (Putative eps protein),   Q64375 (Synaptonemal complex)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:NDPK - Interactions involving proteins containing InterPro domain IPR001564, Nucleoside diphosphate kinase, core.	taxid:10116(rat-l6)|taxid:10116(Rattus norvegicus)	-	2006/02/15	2021/11/30	rogid:PbFY2lfrty8yw40Jq7ShR7xfuV410116	rogid:Nk+zXn0ahm2Fy+jiP75Yp9gWYHk10116	intact-crc:44F3A2176D02515F|rigid:9RVm0UBcqQF4k06RGKO89Bg16Q8	false	myc tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P19357	uniprotkb:Q6P6V0	intact:EBI-915426|uniprotkb:P97900|ensembl:ENSRNOP00000023256	intact:EBI-918999|ensembl:ENSRNOP00000029515	psi-mi:glut4_rat(display_long)|uniprotkb:Glucose transporter type 4, insulin-responsive(gene name synonym)|uniprotkb:Slc2a4(gene name)|psi-mi:Slc2a4(display_short)|uniprotkb:Glut4(gene name synonym)	psi-mi:g6pi_rat(display_long)|uniprotkb:Gpi(gene name)|psi-mi:Gpi(display_short)|uniprotkb:Phosphoglucose isomerase(gene name synonym)|uniprotkb:Phosphohexose isomerase(gene name synonym)|uniprotkb:Autocrine motility factor(gene name synonym)|uniprotkb:Neuroleukin(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Foster et al. (2006)	pubmed:16396496|mint:MINT-5218203	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-921030	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2711|refseq:NP_036883.1|refseq:XP_006246658.1|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007611"(learning or memory)|go:"GO:0007614"(short-term memory)|go:"GO:0007616"(long-term memory)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010021"(amylopectin biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031550"(positive regulation of brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044381"(glucose import in response to insulin stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046323"(glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0098694"(regulation of synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0098793"(presynapse)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002441("Glucose transporter, type 4 (GLUT4)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-189200|ensembl:ENSRNOG00000017226(gene)|ensembl:ENSRNOT00000023256(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)	rgd:2727|refseq:NP_997475.1|ensembl:ENSRNOG00000023150(gene)|ensembl:ENSRNOT00000032613(transcript)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001707"(mesoderm formation)|go:"GO:0002639"(positive regulation of immunoglobulin production)|go:"GO:0004347"(glucose-6-phosphate isomerase activity)|go:"GO:0005125"(cytokine activity)|go:"GO:0005615"(extracellular space)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005975"(carbohydrate metabolic process)|go:"GO:0006094"(gluconeogenesis)|go:"GO:0006096"(glycolytic process)|go:"GO:0007611"(learning or memory)|go:"GO:0008083"(growth factor activity)|go:"GO:0010595"(positive regulation of endothelial cell migration)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032355"(response to estradiol)|go:"GO:0032570"(response to progesterone)|go:"GO:0033574"(response to testosterone)|go:"GO:0034101"(erythrocyte homeostasis)|go:"GO:0035902"(response to immobilization stress)|go:"GO:0035994"(response to muscle stretch)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043005"(neuron projection)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043278"(response to morphine)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0046686"(response to cadmium ion)|go:"GO:0048029"(monosaccharide binding)|go:"GO:0051156"(glucose 6-phosphate metabolic process)|go:"GO:0060170"(ciliary membrane)|interpro:IPR001672("Phosphoglucose isomerase (PGI)")|interpro:IPR018189|interpro:IPR023096|interpro:IPR035476|interpro:IPR035482|reactome:R-RNO-5628897|reactome:R-RNO-6798695|reactome:R-RNO-70171|reactome:R-RNO-70263	-	-	-	caution:"The participant EBI-349571(P68370) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919386(Q7TP47) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920972(Q5XIP9) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-916419(P11980) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919578(Q8R491) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920554(Q5U3Z7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920647(Q5U2X8) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920585(Q7TP24) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-779677(P05426) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-915744(P02454) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|agonist:Insulin was shown to increase or decrease GLUT4 protein interactions in specific cases.|comment:"Insulin decreased GLUT4 interactions with the following proteins: Q9ER30 (Sarcosin), P09527 (Rab-7), O88960 (N-ethylmaleimide sensitive), P09456 (PKA I regulatory subunit), P27881 (Hexokinase type II), P07872 (Acyl-coenzyme A oxidase), Q6DGF1 (Isocitrate dehydrogenase), Q9EQX9 (Ubiquitin-conjugating), Q63446 (Polyubiquitin), P24268 (Cathepsin D), Q91XW0 (Heat shock protein 86), Q5FVH0 (unknown), P58405 (Striatin 3), Q62667 (Major vault protein), Q66H50 (unknown), Q09167 (splicing factor), Q9JHU5 (Arfaptin 1)."|comment:"Insulin increased GLUT4 interaction with the following proteins:Q9Z1P2 (R-actinin-1), P45592 (Cofilin), Q9QXQ0 (R-actinin-4), P26473 (ADP-ribosylation factor), P26437 (ADP-ribosylation factor),   Q7TNP1 (Basigin 2), Q6P6R2 (Dihydrolipoamide dehydrogenase),   P04797 (GAPDH), Q63081 (Protein disulfide isomerase), P29457 (47 kDa heat shock protein), Q9R1J8 (Leprecan), O88638 (Putative eps protein),   Q64375 (Synaptonemal complex)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:NDPK - Interactions involving proteins containing InterPro domain IPR001564, Nucleoside diphosphate kinase, core.	taxid:10116(rat-l6)|taxid:10116(Rattus norvegicus)	-	2006/02/15	2021/11/30	rogid:PbFY2lfrty8yw40Jq7ShR7xfuV410116	rogid:PVOR/rmNkZatD6rcScBNvyOk6HY10116	intact-crc:44F3A2176D02515F|rigid:9RVm0UBcqQF4k06RGKO89Bg16Q8	false	myc tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P19357	uniprotkb:Q6P6R2	intact:EBI-915426|uniprotkb:P97900|ensembl:ENSRNOP00000023256	intact:EBI-918983|ensembl:ENSRNOP00000008980	psi-mi:glut4_rat(display_long)|uniprotkb:Glucose transporter type 4, insulin-responsive(gene name synonym)|uniprotkb:Slc2a4(gene name)|psi-mi:Slc2a4(display_short)|uniprotkb:Glut4(gene name synonym)	psi-mi:dldh_rat(display_long)|uniprotkb:Dld(gene name)|psi-mi:Dld(display_short)|uniprotkb:Dihydrolipoamide dehydrogenase(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Foster et al. (2006)	pubmed:16396496|mint:MINT-5218203	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-921030	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2711|refseq:NP_036883.1|refseq:XP_006246658.1|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007611"(learning or memory)|go:"GO:0007614"(short-term memory)|go:"GO:0007616"(long-term memory)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010021"(amylopectin biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031550"(positive regulation of brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044381"(glucose import in response to insulin stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046323"(glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0098694"(regulation of synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0098793"(presynapse)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002441("Glucose transporter, type 4 (GLUT4)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-189200|ensembl:ENSRNOG00000017226(gene)|ensembl:ENSRNOT00000023256(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)	rgd:735073|refseq:NP_955417.1|ensembl:ENSRNOG00000006364(gene)|ensembl:ENSRNOT00000008980(transcript)|go:"GO:0004148"(dihydrolipoyl dehydrogenase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005929"(cilium)|go:"GO:0006086"(acetyl-CoA biosynthetic process from pyruvate)|go:"GO:0006103"(2-oxoglutarate metabolic process)|go:"GO:0006120"(mitochondrial electron transport, NADH to ubiquinone)|go:"GO:0006508"(proteolysis)|go:"GO:0007369"(gastrulation)|go:"GO:0007568"(aging)|go:"GO:0009106"(lipoate metabolic process)|go:"GO:0031514"(motile cilium)|go:"GO:0034604"("pyruvate dehydrogenase (NAD+) activity")|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0043159"(acrosomal matrix)|go:"GO:0043544"(lipoamide binding)|go:"GO:0045252"(oxoglutarate dehydrogenase complex)|go:"GO:0045254"(pyruvate dehydrogenase complex)|go:"GO:0045454"(cell redox homeostasis)|go:"GO:0048240"(sperm capacitation)|go:"GO:0050660"(flavin adenine dinucleotide binding)|go:"GO:0051068"(dihydrolipoamide metabolic process)|go:"GO:0051287"(NAD binding)|go:"GO:0106077"(histone succinylation)|interpro:IPR001100(Pyridine nucleotide-disulphide oxidoreductase, class I)|interpro:IPR004099(Pyridine nucleotide-disulphide oxidoreductase, dimerisation)|interpro:IPR006258(Dihydrolipoamide dehydrogenase)|interpro:IPR012999(Pyridine nucleotide-disulphide oxidoreductase, class I, active site)|interpro:IPR016156(FAD/NAD-linked reductase, dimerisation)|interpro:IPR023753|interpro:IPR036188|reactome:R-RNO-204174|reactome:R-RNO-389661|reactome:R-RNO-5362517|reactome:R-RNO-6783984|reactome:R-RNO-70268|reactome:R-RNO-70895|reactome:R-RNO-71064|reactome:R-RNO-71403	-	-	-	caution:"The participant EBI-349571(P68370) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919386(Q7TP47) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920972(Q5XIP9) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-916419(P11980) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919578(Q8R491) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920554(Q5U3Z7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920647(Q5U2X8) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920585(Q7TP24) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-779677(P05426) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-915744(P02454) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|agonist:Insulin was shown to increase or decrease GLUT4 protein interactions in specific cases.|comment:"Insulin decreased GLUT4 interactions with the following proteins: Q9ER30 (Sarcosin), P09527 (Rab-7), O88960 (N-ethylmaleimide sensitive), P09456 (PKA I regulatory subunit), P27881 (Hexokinase type II), P07872 (Acyl-coenzyme A oxidase), Q6DGF1 (Isocitrate dehydrogenase), Q9EQX9 (Ubiquitin-conjugating), Q63446 (Polyubiquitin), P24268 (Cathepsin D), Q91XW0 (Heat shock protein 86), Q5FVH0 (unknown), P58405 (Striatin 3), Q62667 (Major vault protein), Q66H50 (unknown), Q09167 (splicing factor), Q9JHU5 (Arfaptin 1)."|comment:"Insulin increased GLUT4 interaction with the following proteins:Q9Z1P2 (R-actinin-1), P45592 (Cofilin), Q9QXQ0 (R-actinin-4), P26473 (ADP-ribosylation factor), P26437 (ADP-ribosylation factor),   Q7TNP1 (Basigin 2), Q6P6R2 (Dihydrolipoamide dehydrogenase),   P04797 (GAPDH), Q63081 (Protein disulfide isomerase), P29457 (47 kDa heat shock protein), Q9R1J8 (Leprecan), O88638 (Putative eps protein),   Q64375 (Synaptonemal complex)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:NDPK - Interactions involving proteins containing InterPro domain IPR001564, Nucleoside diphosphate kinase, core.	taxid:10116(rat-l6)|taxid:10116(Rattus norvegicus)	-	2006/02/15	2021/11/30	rogid:PbFY2lfrty8yw40Jq7ShR7xfuV410116	rogid:nPQaWMwZUe3ppKl4G/qGuUYyTAE10116	intact-crc:44F3A2176D02515F|rigid:9RVm0UBcqQF4k06RGKO89Bg16Q8	false	myc tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P19357	uniprotkb:P68370	intact:EBI-915426|uniprotkb:P97900|ensembl:ENSRNOP00000023256	intact:EBI-349571|uniprotkb:P02551|uniprotkb:P05210|uniprotkb:P05212|uniprotkb:Q6P6G6|ensembl:ENSRNOP00000075232	psi-mi:glut4_rat(display_long)|uniprotkb:Glucose transporter type 4, insulin-responsive(gene name synonym)|uniprotkb:Slc2a4(gene name)|psi-mi:Slc2a4(display_short)|uniprotkb:Glut4(gene name synonym)	psi-mi:tba1a_rat(display_long)|uniprotkb:Tuba1a(gene name)|psi-mi:Tuba1a(display_short)|uniprotkb:Tuba1(gene name synonym)|uniprotkb:Tubulin alpha-1 chain(gene name synonym)|uniprotkb:Alpha-tubulin 1(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Foster et al. (2006)	pubmed:16396496|mint:MINT-5218203	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-921030	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2711|refseq:NP_036883.1|refseq:XP_006246658.1|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007611"(learning or memory)|go:"GO:0007614"(short-term memory)|go:"GO:0007616"(long-term memory)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010021"(amylopectin biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031550"(positive regulation of brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044381"(glucose import in response to insulin stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046323"(glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0098694"(regulation of synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0098793"(presynapse)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002441("Glucose transporter, type 4 (GLUT4)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-189200|ensembl:ENSRNOG00000017226(gene)|ensembl:ENSRNOT00000023256(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)	rgd:619717|refseq:NP_071634.1|go:"GO:0005200"(structural constituent of cytoskeleton)|go:"GO:0005525"(GTP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005874"(microtubule)|go:"GO:0005881"(cytoplasmic microtubule)|go:"GO:0007017"(microtubule-based process)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042802"(identical protein binding)|go:"GO:0043209"(myelin sheath)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045121"(membrane raft)|go:"GO:0050807"(regulation of synapse organization)|go:"GO:0055037"(recycling endosome)|interpro:IPR000217(Tubulin)|interpro:IPR002452(Alpha tubulin)|interpro:IPR003008(Tubulin/FtsZ, GTPase)|interpro:IPR008280(Tubulin/FtsZ, C-terminal)|interpro:IPR017975|interpro:IPR018316|ensembl:ENSRNOG00000060728(gene)|ensembl:ENSRNOT00000083156(transcript)|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0000278"(mitotic cell cycle)|interpro:IPR023123|interpro:IPR036525|interpro:IPR037103|mint:P68370|reactome:R-RNO-190840|reactome:R-RNO-2132295|reactome:R-RNO-2467813|reactome:R-RNO-2500257|reactome:R-RNO-2565942|reactome:R-RNO-3371497|reactome:R-RNO-380259|reactome:R-RNO-380270|reactome:R-RNO-380284|reactome:R-RNO-380320|reactome:R-RNO-437239|reactome:R-RNO-5610787|reactome:R-RNO-5617833|reactome:R-RNO-5620912|reactome:R-RNO-5620924|reactome:R-RNO-5626467|reactome:R-RNO-5663220|reactome:R-RNO-6807878|reactome:R-RNO-6811434|reactome:R-RNO-6811436|reactome:R-RNO-68877|reactome:R-RNO-8852276|reactome:R-RNO-8854518|reactome:R-RNO-8955332|reactome:R-RNO-9646399|reactome:R-RNO-9648025|reactome:R-RNO-9668328|reactome:R-RNO-983189	-	-	-	caution:"The participant EBI-349571(P68370) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919386(Q7TP47) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920972(Q5XIP9) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-916419(P11980) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919578(Q8R491) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920554(Q5U3Z7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920647(Q5U2X8) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920585(Q7TP24) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-779677(P05426) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-915744(P02454) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|agonist:Insulin was shown to increase or decrease GLUT4 protein interactions in specific cases.|comment:"Insulin decreased GLUT4 interactions with the following proteins: Q9ER30 (Sarcosin), P09527 (Rab-7), O88960 (N-ethylmaleimide sensitive), P09456 (PKA I regulatory subunit), P27881 (Hexokinase type II), P07872 (Acyl-coenzyme A oxidase), Q6DGF1 (Isocitrate dehydrogenase), Q9EQX9 (Ubiquitin-conjugating), Q63446 (Polyubiquitin), P24268 (Cathepsin D), Q91XW0 (Heat shock protein 86), Q5FVH0 (unknown), P58405 (Striatin 3), Q62667 (Major vault protein), Q66H50 (unknown), Q09167 (splicing factor), Q9JHU5 (Arfaptin 1)."|comment:"Insulin increased GLUT4 interaction with the following proteins:Q9Z1P2 (R-actinin-1), P45592 (Cofilin), Q9QXQ0 (R-actinin-4), P26473 (ADP-ribosylation factor), P26437 (ADP-ribosylation factor),   Q7TNP1 (Basigin 2), Q6P6R2 (Dihydrolipoamide dehydrogenase),   P04797 (GAPDH), Q63081 (Protein disulfide isomerase), P29457 (47 kDa heat shock protein), Q9R1J8 (Leprecan), O88638 (Putative eps protein),   Q64375 (Synaptonemal complex)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:NDPK - Interactions involving proteins containing InterPro domain IPR001564, Nucleoside diphosphate kinase, core.	taxid:10116(rat-l6)|taxid:10116(Rattus norvegicus)	-	2006/02/15	2021/11/30	rogid:PbFY2lfrty8yw40Jq7ShR7xfuV410116	rogid:1CzEzrf5y8hrQRPKgWQS1Wm1aCY10116	intact-crc:44F3A2176D02515F|rigid:9RVm0UBcqQF4k06RGKO89Bg16Q8	false	myc tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P19357	uniprotkb:Q6P685	intact:EBI-915426|uniprotkb:P97900|ensembl:ENSRNOP00000023256	intact:EBI-918974|ensembl:ENSRNOP00000023786	psi-mi:glut4_rat(display_long)|uniprotkb:Glucose transporter type 4, insulin-responsive(gene name synonym)|uniprotkb:Slc2a4(gene name)|psi-mi:Slc2a4(display_short)|uniprotkb:Glut4(gene name synonym)	psi-mi:q6p685_rat(display_long)|uniprotkb:Eif2s2(gene name)|psi-mi:Eif2s2(display_short)|uniprotkb:rCG_37232(orf name)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Foster et al. (2006)	pubmed:16396496|mint:MINT-5218203	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-921030	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2711|refseq:NP_036883.1|refseq:XP_006246658.1|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007611"(learning or memory)|go:"GO:0007614"(short-term memory)|go:"GO:0007616"(long-term memory)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010021"(amylopectin biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031550"(positive regulation of brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044381"(glucose import in response to insulin stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046323"(glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0098694"(regulation of synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0098793"(presynapse)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002441("Glucose transporter, type 4 (GLUT4)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-189200|ensembl:ENSRNOG00000017226(gene)|ensembl:ENSRNOT00000023256(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)	rgd:735192|refseq:NP_955412.1|ensembl:ENSRNOG00000017447(gene)|ensembl:ENSRNOT00000023786(transcript)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001731"(formation of translation preinitiation complex)|go:"GO:0001732"(formation of cytoplasmic translation initiation complex)|go:"GO:0002176"(male germ cell proliferation)|go:"GO:0003729"(mRNA binding)|go:"GO:0003743"(translation initiation factor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005850"(eukaryotic translation initiation factor 2 complex)|go:"GO:0008584"(male gonad development)|go:"GO:0031369"(translation initiation factor binding)|interpro:IPR002735(Translation initiation factor IF2/IF5)|interpro:IPR016189(Translation initiation factor IF2/IF5, N-terminal)|interpro:IPR016190(Translation initiation factor IF2/IF5, zinc-binding)|reactome:R-RNO-156827|reactome:R-RNO-381042|reactome:R-RNO-382556|reactome:R-RNO-72649|reactome:R-RNO-72695|reactome:R-RNO-72702|reactome:R-RNO-72706|reactome:R-RNO-72731	-	-	-	caution:"The participant EBI-349571(P68370) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919386(Q7TP47) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920972(Q5XIP9) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-916419(P11980) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919578(Q8R491) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920554(Q5U3Z7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920647(Q5U2X8) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920585(Q7TP24) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-779677(P05426) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-915744(P02454) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|agonist:Insulin was shown to increase or decrease GLUT4 protein interactions in specific cases.|comment:"Insulin decreased GLUT4 interactions with the following proteins: Q9ER30 (Sarcosin), P09527 (Rab-7), O88960 (N-ethylmaleimide sensitive), P09456 (PKA I regulatory subunit), P27881 (Hexokinase type II), P07872 (Acyl-coenzyme A oxidase), Q6DGF1 (Isocitrate dehydrogenase), Q9EQX9 (Ubiquitin-conjugating), Q63446 (Polyubiquitin), P24268 (Cathepsin D), Q91XW0 (Heat shock protein 86), Q5FVH0 (unknown), P58405 (Striatin 3), Q62667 (Major vault protein), Q66H50 (unknown), Q09167 (splicing factor), Q9JHU5 (Arfaptin 1)."|comment:"Insulin increased GLUT4 interaction with the following proteins:Q9Z1P2 (R-actinin-1), P45592 (Cofilin), Q9QXQ0 (R-actinin-4), P26473 (ADP-ribosylation factor), P26437 (ADP-ribosylation factor),   Q7TNP1 (Basigin 2), Q6P6R2 (Dihydrolipoamide dehydrogenase),   P04797 (GAPDH), Q63081 (Protein disulfide isomerase), P29457 (47 kDa heat shock protein), Q9R1J8 (Leprecan), O88638 (Putative eps protein),   Q64375 (Synaptonemal complex)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:NDPK - Interactions involving proteins containing InterPro domain IPR001564, Nucleoside diphosphate kinase, core.	taxid:10116(rat-l6)|taxid:10116(Rattus norvegicus)	-	2006/02/15	2021/11/30	rogid:PbFY2lfrty8yw40Jq7ShR7xfuV410116	rogid:eeK9sVPpHtOuBXRhAHGQn6zW7mA10116	intact-crc:44F3A2176D02515F|rigid:9RVm0UBcqQF4k06RGKO89Bg16Q8	false	myc tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P19357	uniprotkb:Q6P503	intact:EBI-915426|uniprotkb:P97900|ensembl:ENSRNOP00000023256	intact:EBI-918965|ensembl:ENSRNOP00000012101	psi-mi:glut4_rat(display_long)|uniprotkb:Glucose transporter type 4, insulin-responsive(gene name synonym)|uniprotkb:Slc2a4(gene name)|psi-mi:Slc2a4(display_short)|uniprotkb:Glut4(gene name synonym)	psi-mi:q6p503_rat(display_long)|uniprotkb:Atp6v1d(gene name)|psi-mi:Atp6v1d(display_short)|uniprotkb:V-type proton ATPase subunit d(gene name synonym)|uniprotkb:Vacuolar proton pump subunit D(gene name synonym)|uniprotkb:rCG_61537(orf name)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Foster et al. (2006)	pubmed:16396496|mint:MINT-5218203	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-921030	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2711|refseq:NP_036883.1|refseq:XP_006246658.1|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007611"(learning or memory)|go:"GO:0007614"(short-term memory)|go:"GO:0007616"(long-term memory)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010021"(amylopectin biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031550"(positive regulation of brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044381"(glucose import in response to insulin stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046323"(glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0098694"(regulation of synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0098793"(presynapse)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002441("Glucose transporter, type 4 (GLUT4)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-189200|ensembl:ENSRNOG00000017226(gene)|ensembl:ENSRNOT00000023256(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)	rgd:735119|refseq:NP_955418.1|ensembl:ENSRNOG00000009080(gene)|ensembl:ENSRNOT00000012101(transcript)|go:"GO:0005813"(centrosome)|go:"GO:0005929"(cilium)|go:"GO:0016020"(membrane)|go:"GO:0033176"(proton-transporting V-type ATPase complex)|go:"GO:0046961"(proton-transporting ATPase activity, rotational mechanism)|go:"GO:0060271"(cilium assembly)|go:"GO:0061512"(protein localization to cilium)|interpro:IPR002699(ATPase, V1/A1 complex, subunit D)|rcsb pdb:6VQ6|rcsb pdb:6VQ7|rcsb pdb:6VQ8|rcsb pdb:6VQ9|rcsb pdb:6VQA|rcsb pdb:6VQB|rcsb pdb:6VQC|rcsb pdb:6VQG|rcsb pdb:6VQH|reactome:R-RNO-1222556|reactome:R-RNO-6798695|reactome:R-RNO-77387|reactome:R-RNO-917977|reactome:R-RNO-9639288|reactome:R-RNO-983712	-	-	-	caution:"The participant EBI-349571(P68370) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919386(Q7TP47) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920972(Q5XIP9) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-916419(P11980) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919578(Q8R491) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920554(Q5U3Z7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920647(Q5U2X8) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920585(Q7TP24) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-779677(P05426) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-915744(P02454) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|agonist:Insulin was shown to increase or decrease GLUT4 protein interactions in specific cases.|comment:"Insulin decreased GLUT4 interactions with the following proteins: Q9ER30 (Sarcosin), P09527 (Rab-7), O88960 (N-ethylmaleimide sensitive), P09456 (PKA I regulatory subunit), P27881 (Hexokinase type II), P07872 (Acyl-coenzyme A oxidase), Q6DGF1 (Isocitrate dehydrogenase), Q9EQX9 (Ubiquitin-conjugating), Q63446 (Polyubiquitin), P24268 (Cathepsin D), Q91XW0 (Heat shock protein 86), Q5FVH0 (unknown), P58405 (Striatin 3), Q62667 (Major vault protein), Q66H50 (unknown), Q09167 (splicing factor), Q9JHU5 (Arfaptin 1)."|comment:"Insulin increased GLUT4 interaction with the following proteins:Q9Z1P2 (R-actinin-1), P45592 (Cofilin), Q9QXQ0 (R-actinin-4), P26473 (ADP-ribosylation factor), P26437 (ADP-ribosylation factor),   Q7TNP1 (Basigin 2), Q6P6R2 (Dihydrolipoamide dehydrogenase),   P04797 (GAPDH), Q63081 (Protein disulfide isomerase), P29457 (47 kDa heat shock protein), Q9R1J8 (Leprecan), O88638 (Putative eps protein),   Q64375 (Synaptonemal complex)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:NDPK - Interactions involving proteins containing InterPro domain IPR001564, Nucleoside diphosphate kinase, core.	taxid:10116(rat-l6)|taxid:10116(Rattus norvegicus)	-	2006/02/15	2021/11/30	rogid:PbFY2lfrty8yw40Jq7ShR7xfuV410116	rogid:hyYHJ3BMiHZ91ZBMo8Y2P3WETC410116	intact-crc:44F3A2176D02515F|rigid:9RVm0UBcqQF4k06RGKO89Bg16Q8	false	myc tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P19357	uniprotkb:Q6P502	intact:EBI-915426|uniprotkb:P97900|ensembl:ENSRNOP00000023256	intact:EBI-918953|ensembl:ENSRNOP00000025824	psi-mi:glut4_rat(display_long)|uniprotkb:Glucose transporter type 4, insulin-responsive(gene name synonym)|uniprotkb:Slc2a4(gene name)|psi-mi:Slc2a4(display_short)|uniprotkb:Glut4(gene name synonym)	psi-mi:tcpg_rat(display_long)|uniprotkb:Cct3(gene name)|psi-mi:Cct3(display_short)|uniprotkb:CCT-gamma(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Foster et al. (2006)	pubmed:16396496|mint:MINT-5218203	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-921030	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2711|refseq:NP_036883.1|refseq:XP_006246658.1|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007611"(learning or memory)|go:"GO:0007614"(short-term memory)|go:"GO:0007616"(long-term memory)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010021"(amylopectin biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031550"(positive regulation of brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044381"(glucose import in response to insulin stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046323"(glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0098694"(regulation of synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0098793"(presynapse)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002441("Glucose transporter, type 4 (GLUT4)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-189200|ensembl:ENSRNOG00000017226(gene)|ensembl:ENSRNOT00000023256(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)	rgd:735038|refseq:NP_954522.1|ensembl:ENSRNOG00000019090(gene)|ensembl:ENSRNOT00000025824(transcript)|go:"GO:0002199"(zona pellucida receptor complex)|go:"GO:0005524"(ATP binding)|go:"GO:0005832"(chaperonin-containing T-complex)|go:"GO:0005874"(microtubule)|go:"GO:0006457"(protein folding)|go:"GO:0007339"(binding of sperm to zona pellucida)|go:"GO:0032212"(positive regulation of telomere maintenance via telomerase)|go:"GO:0044183"(protein folding chaperone)|go:"GO:0044297"(cell body)|go:"GO:0046931"(pore complex assembly)|go:"GO:0050821"(protein stabilization)|go:"GO:0051082"(unfolded protein binding)|go:"GO:1901998"(toxin transport)|go:"GO:1904851"(positive regulation of establishment of protein localization to telomere)|interpro:IPR002194(Chaperonin TCP-1, conserved site)|interpro:IPR002423(Chaperonin Cpn60/TCP-1)|interpro:IPR012719(T-complex protein 1, gamma subunit)|interpro:IPR017998|interpro:IPR027409|interpro:IPR027410|interpro:IPR027413|mint:Q6P502|reactome:R-RNO-390471|reactome:R-RNO-5620922|reactome:R-RNO-6814122	-	-	-	caution:"The participant EBI-349571(P68370) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919386(Q7TP47) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920972(Q5XIP9) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-916419(P11980) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919578(Q8R491) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920554(Q5U3Z7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920647(Q5U2X8) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920585(Q7TP24) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-779677(P05426) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-915744(P02454) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|agonist:Insulin was shown to increase or decrease GLUT4 protein interactions in specific cases.|comment:"Insulin decreased GLUT4 interactions with the following proteins: Q9ER30 (Sarcosin), P09527 (Rab-7), O88960 (N-ethylmaleimide sensitive), P09456 (PKA I regulatory subunit), P27881 (Hexokinase type II), P07872 (Acyl-coenzyme A oxidase), Q6DGF1 (Isocitrate dehydrogenase), Q9EQX9 (Ubiquitin-conjugating), Q63446 (Polyubiquitin), P24268 (Cathepsin D), Q91XW0 (Heat shock protein 86), Q5FVH0 (unknown), P58405 (Striatin 3), Q62667 (Major vault protein), Q66H50 (unknown), Q09167 (splicing factor), Q9JHU5 (Arfaptin 1)."|comment:"Insulin increased GLUT4 interaction with the following proteins:Q9Z1P2 (R-actinin-1), P45592 (Cofilin), Q9QXQ0 (R-actinin-4), P26473 (ADP-ribosylation factor), P26437 (ADP-ribosylation factor),   Q7TNP1 (Basigin 2), Q6P6R2 (Dihydrolipoamide dehydrogenase),   P04797 (GAPDH), Q63081 (Protein disulfide isomerase), P29457 (47 kDa heat shock protein), Q9R1J8 (Leprecan), O88638 (Putative eps protein),   Q64375 (Synaptonemal complex)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:NDPK - Interactions involving proteins containing InterPro domain IPR001564, Nucleoside diphosphate kinase, core.	taxid:10116(rat-l6)|taxid:10116(Rattus norvegicus)	-	2006/02/15	2021/11/30	rogid:PbFY2lfrty8yw40Jq7ShR7xfuV410116	rogid:1JIKeXK/jQ/vqkYLjBGcrCj1PDg10116	intact-crc:44F3A2176D02515F|rigid:9RVm0UBcqQF4k06RGKO89Bg16Q8	false	myc tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P19357	uniprotkb:Q6P4Z9	intact:EBI-915426|uniprotkb:P97900|ensembl:ENSRNOP00000023256	intact:EBI-918947|ensembl:ENSRNOP00000026581	psi-mi:glut4_rat(display_long)|uniprotkb:Glucose transporter type 4, insulin-responsive(gene name synonym)|uniprotkb:Slc2a4(gene name)|psi-mi:Slc2a4(display_short)|uniprotkb:Glut4(gene name synonym)	psi-mi:csn8_rat(display_long)|uniprotkb:Cops8(gene name)|psi-mi:Cops8(display_short)|uniprotkb:Csn8(gene name synonym)|uniprotkb:JAB1-containing signalosome subunit 8(gene name synonym)|uniprotkb:COP9 homolog(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Foster et al. (2006)	pubmed:16396496|mint:MINT-5218203	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-921030	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2711|refseq:NP_036883.1|refseq:XP_006246658.1|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007611"(learning or memory)|go:"GO:0007614"(short-term memory)|go:"GO:0007616"(long-term memory)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010021"(amylopectin biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031550"(positive regulation of brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044381"(glucose import in response to insulin stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046323"(glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0098694"(regulation of synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0098793"(presynapse)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002441("Glucose transporter, type 4 (GLUT4)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-189200|ensembl:ENSRNOG00000017226(gene)|ensembl:ENSRNOT00000023256(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)	rgd:1311404|refseq:NP_001013245.1|ensembl:ENSRNOG00000019635(gene)|ensembl:ENSRNOT00000026581(transcript)|go:"GO:0000338"(protein deneddylation)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007250"(activation of NF-kappaB-inducing kinase activity)|go:"GO:0008180"(COP9 signalosome)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010387"(COP9 signalosome assembly)|go:"GO:0048471"(perinuclear region of cytoplasm)|interpro:IPR000717(Proteasome component region PCI)|interpro:IPR033205|interpro:IPR033464|reactome:R-RNO-5696394|reactome:R-RNO-6781823|reactome:R-RNO-8856825|reactome:R-RNO-8951664	-	-	-	caution:"The participant EBI-349571(P68370) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919386(Q7TP47) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920972(Q5XIP9) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-916419(P11980) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919578(Q8R491) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920554(Q5U3Z7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920647(Q5U2X8) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920585(Q7TP24) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-779677(P05426) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-915744(P02454) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|agonist:Insulin was shown to increase or decrease GLUT4 protein interactions in specific cases.|comment:"Insulin decreased GLUT4 interactions with the following proteins: Q9ER30 (Sarcosin), P09527 (Rab-7), O88960 (N-ethylmaleimide sensitive), P09456 (PKA I regulatory subunit), P27881 (Hexokinase type II), P07872 (Acyl-coenzyme A oxidase), Q6DGF1 (Isocitrate dehydrogenase), Q9EQX9 (Ubiquitin-conjugating), Q63446 (Polyubiquitin), P24268 (Cathepsin D), Q91XW0 (Heat shock protein 86), Q5FVH0 (unknown), P58405 (Striatin 3), Q62667 (Major vault protein), Q66H50 (unknown), Q09167 (splicing factor), Q9JHU5 (Arfaptin 1)."|comment:"Insulin increased GLUT4 interaction with the following proteins:Q9Z1P2 (R-actinin-1), P45592 (Cofilin), Q9QXQ0 (R-actinin-4), P26473 (ADP-ribosylation factor), P26437 (ADP-ribosylation factor),   Q7TNP1 (Basigin 2), Q6P6R2 (Dihydrolipoamide dehydrogenase),   P04797 (GAPDH), Q63081 (Protein disulfide isomerase), P29457 (47 kDa heat shock protein), Q9R1J8 (Leprecan), O88638 (Putative eps protein),   Q64375 (Synaptonemal complex)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:NDPK - Interactions involving proteins containing InterPro domain IPR001564, Nucleoside diphosphate kinase, core.	taxid:10116(rat-l6)|taxid:10116(Rattus norvegicus)	-	2006/02/15	2021/11/30	rogid:PbFY2lfrty8yw40Jq7ShR7xfuV410116	rogid:x+4j2uhUbwIrSboSrRQlQ0XiBfQ10116	intact-crc:44F3A2176D02515F|rigid:9RVm0UBcqQF4k06RGKO89Bg16Q8	false	myc tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P19357	uniprotkb:Q6P2A5	intact:EBI-915426|uniprotkb:P97900|ensembl:ENSRNOP00000023256	intact:EBI-918934|ensembl:ENSRNOP00000070076	psi-mi:glut4_rat(display_long)|uniprotkb:Glucose transporter type 4, insulin-responsive(gene name synonym)|uniprotkb:Slc2a4(gene name)|psi-mi:Slc2a4(display_short)|uniprotkb:Glut4(gene name synonym)	psi-mi:q6p2a5_rat(display_long)|uniprotkb:Ak3(gene name)|psi-mi:Ak3(display_short)|uniprotkb:AK3(gene name synonym)|uniprotkb:Adenylate kinase 3(gene name synonym)|uniprotkb:Adenylate kinase 3 alpha-like 1(gene name synonym)|uniprotkb:rCG_47187(orf name)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Foster et al. (2006)	pubmed:16396496|mint:MINT-5218203	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-921030	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2711|refseq:NP_036883.1|refseq:XP_006246658.1|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007611"(learning or memory)|go:"GO:0007614"(short-term memory)|go:"GO:0007616"(long-term memory)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010021"(amylopectin biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031550"(positive regulation of brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044381"(glucose import in response to insulin stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046323"(glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0098694"(regulation of synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0098793"(presynapse)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002441("Glucose transporter, type 4 (GLUT4)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-189200|ensembl:ENSRNOG00000017226(gene)|ensembl:ENSRNOT00000023256(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)	rgd:619885|ensembl:ENSRNOG00000052506(gene)|ensembl:ENSRNOT00000079875(transcript)|go:"GO:0004017"(adenylate kinase activity)|go:"GO:0004550"(nucleoside diphosphate kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005525"(GTP binding)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0006172"(ADP biosynthetic process)|go:"GO:0046033"(AMP metabolic process)|go:"GO:0046039"(GTP metabolic process)|go:"GO:0046041"(ITP metabolic process)|go:"GO:0046051"(UTP metabolic process)|go:"GO:0046899"(nucleoside triphosphate adenylate kinase activity)|interpro:IPR000850(Adenylate kinase)|interpro:IPR006259(Adenylate kinase, subfamily)|interpro:IPR007862(Adenylate kinase, zinc-finger lid region)|interpro:IPR027417|interpro:IPR028586|interpro:IPR033690|interpro:IPR036193	-	-	-	caution:"The participant EBI-349571(P68370) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919386(Q7TP47) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920972(Q5XIP9) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-916419(P11980) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919578(Q8R491) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920554(Q5U3Z7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920647(Q5U2X8) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920585(Q7TP24) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-779677(P05426) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-915744(P02454) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|agonist:Insulin was shown to increase or decrease GLUT4 protein interactions in specific cases.|comment:"Insulin decreased GLUT4 interactions with the following proteins: Q9ER30 (Sarcosin), P09527 (Rab-7), O88960 (N-ethylmaleimide sensitive), P09456 (PKA I regulatory subunit), P27881 (Hexokinase type II), P07872 (Acyl-coenzyme A oxidase), Q6DGF1 (Isocitrate dehydrogenase), Q9EQX9 (Ubiquitin-conjugating), Q63446 (Polyubiquitin), P24268 (Cathepsin D), Q91XW0 (Heat shock protein 86), Q5FVH0 (unknown), P58405 (Striatin 3), Q62667 (Major vault protein), Q66H50 (unknown), Q09167 (splicing factor), Q9JHU5 (Arfaptin 1)."|comment:"Insulin increased GLUT4 interaction with the following proteins:Q9Z1P2 (R-actinin-1), P45592 (Cofilin), Q9QXQ0 (R-actinin-4), P26473 (ADP-ribosylation factor), P26437 (ADP-ribosylation factor),   Q7TNP1 (Basigin 2), Q6P6R2 (Dihydrolipoamide dehydrogenase),   P04797 (GAPDH), Q63081 (Protein disulfide isomerase), P29457 (47 kDa heat shock protein), Q9R1J8 (Leprecan), O88638 (Putative eps protein),   Q64375 (Synaptonemal complex)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:NDPK - Interactions involving proteins containing InterPro domain IPR001564, Nucleoside diphosphate kinase, core.	taxid:10116(rat-l6)|taxid:10116(Rattus norvegicus)	-	2006/02/15	2021/11/30	rogid:PbFY2lfrty8yw40Jq7ShR7xfuV410116	rogid:NLC8WrNvxKWGXgzpiVLkGEnQu8U10116	intact-crc:44F3A2176D02515F|rigid:9RVm0UBcqQF4k06RGKO89Bg16Q8	false	myc tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P19357	uniprotkb:Q6P0K8	intact:EBI-915426|uniprotkb:P97900|ensembl:ENSRNOP00000023256	intact:EBI-918926|ensembl:ENSRNOP00000043950|ensembl:ENSRNOP00000070840	psi-mi:glut4_rat(display_long)|uniprotkb:Glucose transporter type 4, insulin-responsive(gene name synonym)|uniprotkb:Slc2a4(gene name)|psi-mi:Slc2a4(display_short)|uniprotkb:Glut4(gene name synonym)	psi-mi:plak_rat(display_long)|uniprotkb:Jup(gene name)|psi-mi:Jup(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Foster et al. (2006)	pubmed:16396496|mint:MINT-5218203	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-921030	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2711|refseq:NP_036883.1|refseq:XP_006246658.1|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007611"(learning or memory)|go:"GO:0007614"(short-term memory)|go:"GO:0007616"(long-term memory)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010021"(amylopectin biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031550"(positive regulation of brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044381"(glucose import in response to insulin stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046323"(glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0098694"(regulation of synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0098793"(presynapse)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002441("Glucose transporter, type 4 (GLUT4)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-189200|ensembl:ENSRNOG00000017226(gene)|ensembl:ENSRNOT00000023256(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)	rgd:620412|refseq:NP_112309.2|refseq:XP_006247491.1|refseq:XP_006247492.1|refseq:XP_017453037.1|ensembl:ENSRNOG00000015380(gene)|ensembl:ENSRNOT00000040845(transcript)|ensembl:ENSRNOT00000089933(transcript)|go:"GO:0001954"(positive regulation of cell-matrix adhesion)|go:"GO:0002159"(desmosome assembly)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005882"(intermediate filament)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005912"(adherens junction)|go:"GO:0005916"(fascia adherens)|go:"GO:0007155"(cell adhesion)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0014704"(intercalated disc)|go:"GO:0016327"(apicolateral plasma membrane)|go:"GO:0016328"(lateral plasma membrane)|go:"GO:0016342"(catenin complex)|go:"GO:0016477"(cell migration)|go:"GO:0016922"(nuclear receptor binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030018"(Z disc)|go:"GO:0030057"(desmosome)|go:"GO:0032993"(protein-DNA complex)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0043537"(negative regulation of blood vessel endothelial cell migration)|go:"GO:0043588"(skin development)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045294"(alpha-catenin binding)|go:"GO:0045296"(cadherin binding)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050982"(detection of mechanical stimulus)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0071665"(gamma-catenin-TCF7L2 complex)|go:"GO:0071681"(cellular response to indole-3-methanol)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0086073"(bundle of His cell-Purkinje myocyte adhesion involved in cell communication)|go:"GO:0086091"(regulation of heart rate by cardiac conduction)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0098911"(regulation of ventricular cardiac muscle cell action potential)|go:"GO:0106006"(cytoskeletal protein-membrane anchor activity)|interpro:IPR000225(Armadillo)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR013284(Beta-catenin)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR030461|reactome:R-RNO-418990|reactome:R-RNO-5218920|reactome:R-RNO-6798695|reactome:R-RNO-6805567|reactome:R-RNO-6809371|reactome:R-RNO-8980692|reactome:R-RNO-9013026|reactome:R-RNO-9013106|reactome:R-RNO-9013148|reactome:R-RNO-9013406|reactome:R-RNO-9013407	-	-	-	caution:"The participant EBI-349571(P68370) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919386(Q7TP47) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920972(Q5XIP9) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-916419(P11980) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919578(Q8R491) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920554(Q5U3Z7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920647(Q5U2X8) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920585(Q7TP24) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-779677(P05426) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-915744(P02454) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|agonist:Insulin was shown to increase or decrease GLUT4 protein interactions in specific cases.|comment:"Insulin decreased GLUT4 interactions with the following proteins: Q9ER30 (Sarcosin), P09527 (Rab-7), O88960 (N-ethylmaleimide sensitive), P09456 (PKA I regulatory subunit), P27881 (Hexokinase type II), P07872 (Acyl-coenzyme A oxidase), Q6DGF1 (Isocitrate dehydrogenase), Q9EQX9 (Ubiquitin-conjugating), Q63446 (Polyubiquitin), P24268 (Cathepsin D), Q91XW0 (Heat shock protein 86), Q5FVH0 (unknown), P58405 (Striatin 3), Q62667 (Major vault protein), Q66H50 (unknown), Q09167 (splicing factor), Q9JHU5 (Arfaptin 1)."|comment:"Insulin increased GLUT4 interaction with the following proteins:Q9Z1P2 (R-actinin-1), P45592 (Cofilin), Q9QXQ0 (R-actinin-4), P26473 (ADP-ribosylation factor), P26437 (ADP-ribosylation factor),   Q7TNP1 (Basigin 2), Q6P6R2 (Dihydrolipoamide dehydrogenase),   P04797 (GAPDH), Q63081 (Protein disulfide isomerase), P29457 (47 kDa heat shock protein), Q9R1J8 (Leprecan), O88638 (Putative eps protein),   Q64375 (Synaptonemal complex)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:NDPK - Interactions involving proteins containing InterPro domain IPR001564, Nucleoside diphosphate kinase, core.	taxid:10116(rat-l6)|taxid:10116(Rattus norvegicus)	-	2006/02/15	2021/11/30	rogid:PbFY2lfrty8yw40Jq7ShR7xfuV410116	rogid:yWbzwtNtLlRBegMUJ6YQyJzQpXE10116	intact-crc:44F3A2176D02515F|rigid:9RVm0UBcqQF4k06RGKO89Bg16Q8	false	myc tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P19357	uniprotkb:Q6NYB7	intact:EBI-915426|uniprotkb:P97900|ensembl:ENSRNOP00000023256	intact:EBI-918913|uniprotkb:P05711|ensembl:ENSRNOP00000073493	psi-mi:glut4_rat(display_long)|uniprotkb:Glucose transporter type 4, insulin-responsive(gene name synonym)|uniprotkb:Slc2a4(gene name)|psi-mi:Slc2a4(display_short)|uniprotkb:Glut4(gene name synonym)	psi-mi:rab1a_rat(display_long)|uniprotkb:Rab1A(gene name)|psi-mi:Rab1A(display_short)|uniprotkb:Rab1(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Foster et al. (2006)	pubmed:16396496|mint:MINT-5218203	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-921030	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2711|refseq:NP_036883.1|refseq:XP_006246658.1|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007611"(learning or memory)|go:"GO:0007614"(short-term memory)|go:"GO:0007616"(long-term memory)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010021"(amylopectin biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031550"(positive regulation of brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044381"(glucose import in response to insulin stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046323"(glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0098694"(regulation of synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0098793"(presynapse)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002441("Glucose transporter, type 4 (GLUT4)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-189200|ensembl:ENSRNOG00000017226(gene)|ensembl:ENSRNOT00000023256(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)	rgd:619736|refseq:NP_112352.2|ensembl:ENSRNOG00000004992(gene)|ensembl:ENSRNOT00000084481(transcript)|go:"GO:0000045"(autophagosome assembly)|go:"GO:0000139"(Golgi membrane)|go:"GO:0003924"(GTPase activity)|go:"GO:0003925"(G protein activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005769"(early endosome)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006888"(endoplasmic reticulum to Golgi vesicle-mediated transport)|go:"GO:0006897"(endocytosis)|go:"GO:0006914"(autophagy)|go:"GO:0007030"(Golgi organization)|go:"GO:0012505"(endomembrane system)|go:"GO:0016477"(cell migration)|go:"GO:0019068"(virion assembly)|go:"GO:0030252"(growth hormone secretion)|go:"GO:0032402"(melanosome transport)|go:"GO:0032482"(Rab protein signal transduction)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0034446"(substrate adhesion-dependent cell spreading)|go:"GO:0042470"(melanosome)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0043025"(neuronal cell body)|go:"GO:0047496"(vesicle transport along microtubule)|go:"GO:0090110"(COPII-coated vesicle cargo loading)|go:"GO:0098793"(presynapse)|go:"GO:1903020"(positive regulation of glycoprotein metabolic process)|interpro:IPR001806(Ras GTPase)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR027417|mint:Q6NYB7|reactome:R-RNO-162658|reactome:R-RNO-204005|reactome:R-RNO-6807878|reactome:R-RNO-6811434|reactome:R-RNO-8873719|reactome:R-RNO-8876198	-	-	-	caution:"The participant EBI-349571(P68370) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919386(Q7TP47) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920972(Q5XIP9) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-916419(P11980) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919578(Q8R491) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920554(Q5U3Z7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920647(Q5U2X8) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920585(Q7TP24) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-779677(P05426) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-915744(P02454) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|agonist:Insulin was shown to increase or decrease GLUT4 protein interactions in specific cases.|comment:"Insulin decreased GLUT4 interactions with the following proteins: Q9ER30 (Sarcosin), P09527 (Rab-7), O88960 (N-ethylmaleimide sensitive), P09456 (PKA I regulatory subunit), P27881 (Hexokinase type II), P07872 (Acyl-coenzyme A oxidase), Q6DGF1 (Isocitrate dehydrogenase), Q9EQX9 (Ubiquitin-conjugating), Q63446 (Polyubiquitin), P24268 (Cathepsin D), Q91XW0 (Heat shock protein 86), Q5FVH0 (unknown), P58405 (Striatin 3), Q62667 (Major vault protein), Q66H50 (unknown), Q09167 (splicing factor), Q9JHU5 (Arfaptin 1)."|comment:"Insulin increased GLUT4 interaction with the following proteins:Q9Z1P2 (R-actinin-1), P45592 (Cofilin), Q9QXQ0 (R-actinin-4), P26473 (ADP-ribosylation factor), P26437 (ADP-ribosylation factor),   Q7TNP1 (Basigin 2), Q6P6R2 (Dihydrolipoamide dehydrogenase),   P04797 (GAPDH), Q63081 (Protein disulfide isomerase), P29457 (47 kDa heat shock protein), Q9R1J8 (Leprecan), O88638 (Putative eps protein),   Q64375 (Synaptonemal complex)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:NDPK - Interactions involving proteins containing InterPro domain IPR001564, Nucleoside diphosphate kinase, core.	taxid:10116(rat-l6)|taxid:10116(Rattus norvegicus)	-	2006/02/15	2021/11/30	rogid:PbFY2lfrty8yw40Jq7ShR7xfuV410116	rogid:Pa9NYKiCNXtxRwthh1r/pGbZyf010116	intact-crc:44F3A2176D02515F|rigid:9RVm0UBcqQF4k06RGKO89Bg16Q8	false	myc tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P19357	uniprotkb:Q68FV6	intact:EBI-915426|uniprotkb:P97900|ensembl:ENSRNOP00000023256	intact:EBI-920403|ensembl:ENSRNOP00000026152	psi-mi:glut4_rat(display_long)|uniprotkb:Glucose transporter type 4, insulin-responsive(gene name synonym)|uniprotkb:Slc2a4(gene name)|psi-mi:Slc2a4(display_short)|uniprotkb:Glut4(gene name synonym)	psi-mi:glmp_rat(display_long)|uniprotkb:Glmp(gene name)|psi-mi:Glmp(display_short)|uniprotkb:Lysosomal protein NCU-G1(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Foster et al. (2006)	pubmed:16396496|mint:MINT-5218203	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-921030	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2711|refseq:NP_036883.1|refseq:XP_006246658.1|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007611"(learning or memory)|go:"GO:0007614"(short-term memory)|go:"GO:0007616"(long-term memory)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010021"(amylopectin biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031550"(positive regulation of brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044381"(glucose import in response to insulin stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046323"(glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0098694"(regulation of synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0098793"(presynapse)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002441("Glucose transporter, type 4 (GLUT4)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-189200|ensembl:ENSRNOG00000017226(gene)|ensembl:ENSRNOT00000023256(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)	rgd:1303130|refseq:NP_001004226.1|ensembl:ENSRNOG00000019281(gene)|ensembl:ENSRNOT00000026153(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005829"(cytosol)|go:"GO:0016021"(integral component of membrane)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0050821"(protein stabilization)|go:"GO:0061462"(protein localization to lysosome)|interpro:IPR029382	-	-	-	caution:"The participant EBI-349571(P68370) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919386(Q7TP47) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920972(Q5XIP9) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-916419(P11980) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919578(Q8R491) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920554(Q5U3Z7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920647(Q5U2X8) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920585(Q7TP24) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-779677(P05426) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-915744(P02454) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|agonist:Insulin was shown to increase or decrease GLUT4 protein interactions in specific cases.|comment:"Insulin decreased GLUT4 interactions with the following proteins: Q9ER30 (Sarcosin), P09527 (Rab-7), O88960 (N-ethylmaleimide sensitive), P09456 (PKA I regulatory subunit), P27881 (Hexokinase type II), P07872 (Acyl-coenzyme A oxidase), Q6DGF1 (Isocitrate dehydrogenase), Q9EQX9 (Ubiquitin-conjugating), Q63446 (Polyubiquitin), P24268 (Cathepsin D), Q91XW0 (Heat shock protein 86), Q5FVH0 (unknown), P58405 (Striatin 3), Q62667 (Major vault protein), Q66H50 (unknown), Q09167 (splicing factor), Q9JHU5 (Arfaptin 1)."|comment:"Insulin increased GLUT4 interaction with the following proteins:Q9Z1P2 (R-actinin-1), P45592 (Cofilin), Q9QXQ0 (R-actinin-4), P26473 (ADP-ribosylation factor), P26437 (ADP-ribosylation factor),   Q7TNP1 (Basigin 2), Q6P6R2 (Dihydrolipoamide dehydrogenase),   P04797 (GAPDH), Q63081 (Protein disulfide isomerase), P29457 (47 kDa heat shock protein), Q9R1J8 (Leprecan), O88638 (Putative eps protein),   Q64375 (Synaptonemal complex)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:NDPK - Interactions involving proteins containing InterPro domain IPR001564, Nucleoside diphosphate kinase, core.	taxid:10116(rat-l6)|taxid:10116(Rattus norvegicus)	-	2006/02/15	2021/11/30	rogid:PbFY2lfrty8yw40Jq7ShR7xfuV410116	rogid:1aQNpZ/0tHTU9vp1/Ou1ZuuUtvw10116	intact-crc:44F3A2176D02515F|rigid:9RVm0UBcqQF4k06RGKO89Bg16Q8	false	myc tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P19357	uniprotkb:Q8R4A1	intact:EBI-915426|uniprotkb:P97900|ensembl:ENSRNOP00000023256	intact:EBI-919590|uniprotkb:Q8VH29|uniprotkb:Q8VH30|ensembl:ENSRNOP00000009404	psi-mi:glut4_rat(display_long)|uniprotkb:Glucose transporter type 4, insulin-responsive(gene name synonym)|uniprotkb:Slc2a4(gene name)|psi-mi:Slc2a4(display_short)|uniprotkb:Glut4(gene name synonym)	psi-mi:ero1a_rat(display_long)|uniprotkb:Ero1a(gene name)|psi-mi:Ero1a(display_short)|uniprotkb:Endoplasmic reticulum oxidoreductase alpha(gene name synonym)|uniprotkb:Endoplasmic reticulum oxidoreductin-1-like protein(gene name synonym)|uniprotkb:Ero1l(gene name synonym)|uniprotkb:Giig11(gene name synonym)|uniprotkb:Global ischemia-induced protein 11(gene name synonym)|uniprotkb:Oxidoreductin-1-L-alpha(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Foster et al. (2006)	pubmed:16396496|mint:MINT-5218203	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-921030	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2711|refseq:NP_036883.1|refseq:XP_006246658.1|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007611"(learning or memory)|go:"GO:0007614"(short-term memory)|go:"GO:0007616"(long-term memory)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010021"(amylopectin biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031550"(positive regulation of brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044381"(glucose import in response to insulin stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046323"(glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0098694"(regulation of synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0098793"(presynapse)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002441("Glucose transporter, type 4 (GLUT4)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-189200|ensembl:ENSRNOG00000017226(gene)|ensembl:ENSRNOT00000023256(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)	rgd:621713|refseq:NP_612537.1|ensembl:ENSRNOG00000006462(gene)|ensembl:ENSRNOT00000009404(transcript)|go:"GO:0003756"(protein disulfide isomerase activity)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0006457"(protein folding)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0010260"(animal organ senescence)|go:"GO:0015035"(protein-disulfide reductase activity)|go:"GO:0016491"(oxidoreductase activity)|go:"GO:0016972"(thiol oxidase activity)|go:"GO:0018401"(peptidyl-proline hydroxylation to 4-hydroxy-L-proline)|go:"GO:0022417"(protein maturation by protein folding)|go:"GO:0030198"(extracellular matrix organization)|go:"GO:0030425"(dendrite)|go:"GO:0030968"(endoplasmic reticulum unfolded protein response)|go:"GO:0034975"(protein folding in endoplasmic reticulum)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0045454"(cell redox homeostasis)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0051085"(chaperone cofactor-dependent protein refolding)|go:"GO:0051209"(release of sequestered calcium ion into cytosol)|go:"GO:0070059"(intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071949"(FAD binding)|interpro:IPR007266(Endoplasmic reticulum oxidoreductin 1)|interpro:IPR037192|reactome:R-RNO-264876|reactome:R-RNO-3299685	-	-	-	caution:"The participant EBI-349571(P68370) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919386(Q7TP47) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920972(Q5XIP9) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-916419(P11980) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919578(Q8R491) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920554(Q5U3Z7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920647(Q5U2X8) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920585(Q7TP24) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-779677(P05426) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-915744(P02454) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|agonist:Insulin was shown to increase or decrease GLUT4 protein interactions in specific cases.|comment:"Insulin decreased GLUT4 interactions with the following proteins: Q9ER30 (Sarcosin), P09527 (Rab-7), O88960 (N-ethylmaleimide sensitive), P09456 (PKA I regulatory subunit), P27881 (Hexokinase type II), P07872 (Acyl-coenzyme A oxidase), Q6DGF1 (Isocitrate dehydrogenase), Q9EQX9 (Ubiquitin-conjugating), Q63446 (Polyubiquitin), P24268 (Cathepsin D), Q91XW0 (Heat shock protein 86), Q5FVH0 (unknown), P58405 (Striatin 3), Q62667 (Major vault protein), Q66H50 (unknown), Q09167 (splicing factor), Q9JHU5 (Arfaptin 1)."|comment:"Insulin increased GLUT4 interaction with the following proteins:Q9Z1P2 (R-actinin-1), P45592 (Cofilin), Q9QXQ0 (R-actinin-4), P26473 (ADP-ribosylation factor), P26437 (ADP-ribosylation factor),   Q7TNP1 (Basigin 2), Q6P6R2 (Dihydrolipoamide dehydrogenase),   P04797 (GAPDH), Q63081 (Protein disulfide isomerase), P29457 (47 kDa heat shock protein), Q9R1J8 (Leprecan), O88638 (Putative eps protein),   Q64375 (Synaptonemal complex)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:NDPK - Interactions involving proteins containing InterPro domain IPR001564, Nucleoside diphosphate kinase, core.	taxid:10116(rat-l6)|taxid:10116(Rattus norvegicus)	-	2006/02/15	2021/11/30	rogid:PbFY2lfrty8yw40Jq7ShR7xfuV410116	rogid:k/271vIeRukXRS4D3KXtB/fs+5Q10116	intact-crc:44F3A2176D02515F|rigid:9RVm0UBcqQF4k06RGKO89Bg16Q8	false	myc tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P19357	uniprotkb:Q6AY48	intact:EBI-915426|uniprotkb:P97900|ensembl:ENSRNOP00000023256	intact:EBI-920396|ensembl:ENSRNOP00000001675	psi-mi:glut4_rat(display_long)|uniprotkb:Glucose transporter type 4, insulin-responsive(gene name synonym)|uniprotkb:Slc2a4(gene name)|psi-mi:Slc2a4(display_short)|uniprotkb:Glut4(gene name synonym)	psi-mi:q6ay48_rat(display_long)|uniprotkb:Pcbp3(gene name)|psi-mi:Pcbp3(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Foster et al. (2006)	pubmed:16396496|mint:MINT-5218203	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-921030	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2711|refseq:NP_036883.1|refseq:XP_006246658.1|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007611"(learning or memory)|go:"GO:0007614"(short-term memory)|go:"GO:0007616"(long-term memory)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010021"(amylopectin biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031550"(positive regulation of brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044381"(glucose import in response to insulin stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046323"(glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0098694"(regulation of synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0098793"(presynapse)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002441("Glucose transporter, type 4 (GLUT4)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-189200|ensembl:ENSRNOG00000017226(gene)|ensembl:ENSRNOT00000023256(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)	rgd:1307430|refseq:NP_001011945.2|ensembl:ENSRNOG00000001245(gene)|ensembl:ENSRNOT00000001675(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0051252"(regulation of RNA metabolic process)|go:"GO:1990829"(C-rich single-stranded DNA binding)|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR036612|mint:Q6AY48	-	-	-	caution:"The participant EBI-349571(P68370) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919386(Q7TP47) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920972(Q5XIP9) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-916419(P11980) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919578(Q8R491) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920554(Q5U3Z7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920647(Q5U2X8) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920585(Q7TP24) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-779677(P05426) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-915744(P02454) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|agonist:Insulin was shown to increase or decrease GLUT4 protein interactions in specific cases.|comment:"Insulin decreased GLUT4 interactions with the following proteins: Q9ER30 (Sarcosin), P09527 (Rab-7), O88960 (N-ethylmaleimide sensitive), P09456 (PKA I regulatory subunit), P27881 (Hexokinase type II), P07872 (Acyl-coenzyme A oxidase), Q6DGF1 (Isocitrate dehydrogenase), Q9EQX9 (Ubiquitin-conjugating), Q63446 (Polyubiquitin), P24268 (Cathepsin D), Q91XW0 (Heat shock protein 86), Q5FVH0 (unknown), P58405 (Striatin 3), Q62667 (Major vault protein), Q66H50 (unknown), Q09167 (splicing factor), Q9JHU5 (Arfaptin 1)."|comment:"Insulin increased GLUT4 interaction with the following proteins:Q9Z1P2 (R-actinin-1), P45592 (Cofilin), Q9QXQ0 (R-actinin-4), P26473 (ADP-ribosylation factor), P26437 (ADP-ribosylation factor),   Q7TNP1 (Basigin 2), Q6P6R2 (Dihydrolipoamide dehydrogenase),   P04797 (GAPDH), Q63081 (Protein disulfide isomerase), P29457 (47 kDa heat shock protein), Q9R1J8 (Leprecan), O88638 (Putative eps protein),   Q64375 (Synaptonemal complex)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:NDPK - Interactions involving proteins containing InterPro domain IPR001564, Nucleoside diphosphate kinase, core.	taxid:10116(rat-l6)|taxid:10116(Rattus norvegicus)	-	2006/02/15	2021/11/30	rogid:PbFY2lfrty8yw40Jq7ShR7xfuV410116	rogid:KVM2SC63rpuFJYCGgeE78vGz+2010116	intact-crc:44F3A2176D02515F|rigid:9RVm0UBcqQF4k06RGKO89Bg16Q8	false	myc tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P19357	uniprotkb:P56571	intact:EBI-915426|uniprotkb:P97900|ensembl:ENSRNOP00000023256	intact:EBI-920390|uniprotkb:Q68FS5|ensembl:ENSRNOP00000001609	psi-mi:glut4_rat(display_long)|uniprotkb:Glucose transporter type 4, insulin-responsive(gene name synonym)|uniprotkb:Slc2a4(gene name)|psi-mi:Slc2a4(display_short)|uniprotkb:Glut4(gene name synonym)	psi-mi:es1_rat(display_long)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Foster et al. (2006)	pubmed:16396496|mint:MINT-5218203	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-921030	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2711|refseq:NP_036883.1|refseq:XP_006246658.1|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007611"(learning or memory)|go:"GO:0007614"(short-term memory)|go:"GO:0007616"(long-term memory)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010021"(amylopectin biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031550"(positive regulation of brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044381"(glucose import in response to insulin stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046323"(glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0098694"(regulation of synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0098793"(presynapse)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002441("Glucose transporter, type 4 (GLUT4)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-189200|ensembl:ENSRNOG00000017226(gene)|ensembl:ENSRNOT00000023256(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)	rgd:1303003|refseq:NP_001004225.1|ensembl:ENSRNOG00000001211(gene)|ensembl:ENSRNOT00000001609(transcript)|go:"GO:0005739"(mitochondrion)|interpro:IPR029062	-	-	-	caution:"The participant EBI-349571(P68370) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919386(Q7TP47) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920972(Q5XIP9) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-916419(P11980) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919578(Q8R491) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920554(Q5U3Z7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920647(Q5U2X8) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920585(Q7TP24) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-779677(P05426) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-915744(P02454) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|agonist:Insulin was shown to increase or decrease GLUT4 protein interactions in specific cases.|comment:"Insulin decreased GLUT4 interactions with the following proteins: Q9ER30 (Sarcosin), P09527 (Rab-7), O88960 (N-ethylmaleimide sensitive), P09456 (PKA I regulatory subunit), P27881 (Hexokinase type II), P07872 (Acyl-coenzyme A oxidase), Q6DGF1 (Isocitrate dehydrogenase), Q9EQX9 (Ubiquitin-conjugating), Q63446 (Polyubiquitin), P24268 (Cathepsin D), Q91XW0 (Heat shock protein 86), Q5FVH0 (unknown), P58405 (Striatin 3), Q62667 (Major vault protein), Q66H50 (unknown), Q09167 (splicing factor), Q9JHU5 (Arfaptin 1)."|comment:"Insulin increased GLUT4 interaction with the following proteins:Q9Z1P2 (R-actinin-1), P45592 (Cofilin), Q9QXQ0 (R-actinin-4), P26473 (ADP-ribosylation factor), P26437 (ADP-ribosylation factor),   Q7TNP1 (Basigin 2), Q6P6R2 (Dihydrolipoamide dehydrogenase),   P04797 (GAPDH), Q63081 (Protein disulfide isomerase), P29457 (47 kDa heat shock protein), Q9R1J8 (Leprecan), O88638 (Putative eps protein),   Q64375 (Synaptonemal complex)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:NDPK - Interactions involving proteins containing InterPro domain IPR001564, Nucleoside diphosphate kinase, core.	taxid:10116(rat-l6)|taxid:10116(Rattus norvegicus)	-	2006/02/15	2021/11/30	rogid:PbFY2lfrty8yw40Jq7ShR7xfuV410116	rogid:jNFrNEoi5tsagbaEsiKPB5y1fMI10116	intact-crc:44F3A2176D02515F|rigid:9RVm0UBcqQF4k06RGKO89Bg16Q8	false	myc tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P19357	uniprotkb:Q5XIH3	intact:EBI-915426|uniprotkb:P97900|ensembl:ENSRNOP00000023256	intact:EBI-920376|ensembl:ENSRNOP00000024517	psi-mi:glut4_rat(display_long)|uniprotkb:Glucose transporter type 4, insulin-responsive(gene name synonym)|uniprotkb:Slc2a4(gene name)|psi-mi:Slc2a4(display_short)|uniprotkb:Glut4(gene name synonym)	psi-mi:q5xih3_rat(display_long)|uniprotkb:Ndufv1(gene name)|psi-mi:Ndufv1(display_short)|uniprotkb:rCG_47623(orf name)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Foster et al. (2006)	pubmed:16396496|mint:MINT-5218203	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-921030	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2711|refseq:NP_036883.1|refseq:XP_006246658.1|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007611"(learning or memory)|go:"GO:0007614"(short-term memory)|go:"GO:0007616"(long-term memory)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010021"(amylopectin biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031550"(positive regulation of brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044381"(glucose import in response to insulin stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046323"(glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0098694"(regulation of synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0098793"(presynapse)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002441("Glucose transporter, type 4 (GLUT4)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-189200|ensembl:ENSRNOG00000017226(gene)|ensembl:ENSRNOT00000023256(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)	rgd:1359247|refseq:NP_001006973.1|ensembl:ENSRNOG00000018117(gene)|ensembl:ENSRNOT00000024517(transcript)|go:"GO:0005747"(mitochondrial respiratory chain complex I)|go:"GO:0005829"(cytosol)|go:"GO:0006120"(mitochondrial electron transport, NADH to ubiquinone)|go:"GO:0008137"("NADH dehydrogenase (ubiquinone) activity")|go:"GO:0010181"(FMN binding)|go:"GO:0042775"(mitochondrial ATP synthesis coupled electron transport)|go:"GO:0046872"(metal ion binding)|go:"GO:0051287"(NAD binding)|go:"GO:0051539"(4 iron, 4 sulfur cluster binding)|interpro:IPR001949(NADH-ubiquinone oxidoreductase, 51 kDa subunit, conserved site)|interpro:IPR011537(NADH-ubiquinone oxidoreductase, F subunit)|interpro:IPR011538(NADH-ubiquinone oxidoreductase, 51 kDa subunit)|interpro:IPR019554|interpro:IPR019575|interpro:IPR037207|interpro:IPR037225|reactome:R-RNO-611105|reactome:R-RNO-6799198	-	-	-	caution:"The participant EBI-349571(P68370) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919386(Q7TP47) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920972(Q5XIP9) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-916419(P11980) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919578(Q8R491) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920554(Q5U3Z7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920647(Q5U2X8) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920585(Q7TP24) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-779677(P05426) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-915744(P02454) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|agonist:Insulin was shown to increase or decrease GLUT4 protein interactions in specific cases.|comment:"Insulin decreased GLUT4 interactions with the following proteins: Q9ER30 (Sarcosin), P09527 (Rab-7), O88960 (N-ethylmaleimide sensitive), P09456 (PKA I regulatory subunit), P27881 (Hexokinase type II), P07872 (Acyl-coenzyme A oxidase), Q6DGF1 (Isocitrate dehydrogenase), Q9EQX9 (Ubiquitin-conjugating), Q63446 (Polyubiquitin), P24268 (Cathepsin D), Q91XW0 (Heat shock protein 86), Q5FVH0 (unknown), P58405 (Striatin 3), Q62667 (Major vault protein), Q66H50 (unknown), Q09167 (splicing factor), Q9JHU5 (Arfaptin 1)."|comment:"Insulin increased GLUT4 interaction with the following proteins:Q9Z1P2 (R-actinin-1), P45592 (Cofilin), Q9QXQ0 (R-actinin-4), P26473 (ADP-ribosylation factor), P26437 (ADP-ribosylation factor),   Q7TNP1 (Basigin 2), Q6P6R2 (Dihydrolipoamide dehydrogenase),   P04797 (GAPDH), Q63081 (Protein disulfide isomerase), P29457 (47 kDa heat shock protein), Q9R1J8 (Leprecan), O88638 (Putative eps protein),   Q64375 (Synaptonemal complex)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:NDPK - Interactions involving proteins containing InterPro domain IPR001564, Nucleoside diphosphate kinase, core.	taxid:10116(rat-l6)|taxid:10116(Rattus norvegicus)	-	2006/02/15	2021/11/30	rogid:PbFY2lfrty8yw40Jq7ShR7xfuV410116	rogid:Nq1TqAXPtlX/xd62JozW+f9Lusw10116	intact-crc:44F3A2176D02515F|rigid:9RVm0UBcqQF4k06RGKO89Bg16Q8	false	myc tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P19357	uniprotkb:Q3MHT4	intact:EBI-915426|uniprotkb:P97900|ensembl:ENSRNOP00000023256	intact:EBI-920366|ensembl:ENSRNOP00000027187	psi-mi:glut4_rat(display_long)|uniprotkb:Glucose transporter type 4, insulin-responsive(gene name synonym)|uniprotkb:Slc2a4(gene name)|psi-mi:Slc2a4(display_short)|uniprotkb:Glut4(gene name synonym)	psi-mi:stpap_rat(display_long)|uniprotkb:Tut1(gene name)|psi-mi:Tut1(display_short)|uniprotkb:RNA-binding motif protein 21(gene name synonym)|uniprotkb:Rbm21(gene name synonym)|uniprotkb:U6 snRNA-specific terminal uridylyltransferase 1(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Foster et al. (2006)	pubmed:16396496|mint:MINT-5218203	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-921030	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2711|refseq:NP_036883.1|refseq:XP_006246658.1|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007611"(learning or memory)|go:"GO:0007614"(short-term memory)|go:"GO:0007616"(long-term memory)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010021"(amylopectin biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031550"(positive regulation of brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044381"(glucose import in response to insulin stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046323"(glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0098694"(regulation of synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0098793"(presynapse)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002441("Glucose transporter, type 4 (GLUT4)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-189200|ensembl:ENSRNOG00000017226(gene)|ensembl:ENSRNOT00000023256(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)	rgd:1561043|refseq:NP_001029073.1|go:"GO:0016779"(nucleotidyltransferase activity)|go:"GO:0017070"(U6 snRNA binding)|go:"GO:0019899"(enzyme binding)|go:"GO:0031123"(RNA 3'-end processing)|go:"GO:0034477"(U6 snRNA 3'-end processing)|go:"GO:0050265"(RNA uridylyltransferase activity)|go:"GO:0098789"(pre-mRNA cleavage required for polyadenylation)|go:"GO:1990817"(RNA adenylyltransferase activity)|ensembl:ENSRNOG00000020047(gene)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR002058(PAP/25A-associated)|interpro:IPR003604(Zinc finger, U1-type)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR034388|interpro:IPR035979|interpro:IPR036236|interpro:IPR043519|ensembl:ENSRNOT00000027187(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0004652"(polynucleotide adenylyltransferase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005730"(nucleolus)|go:"GO:0006378"(mRNA polyadenylation)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016180"(snRNA processing)|go:"GO:0016607"(nuclear speck)	-	-	-	caution:"The participant EBI-349571(P68370) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919386(Q7TP47) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920972(Q5XIP9) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-916419(P11980) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919578(Q8R491) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920554(Q5U3Z7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920647(Q5U2X8) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920585(Q7TP24) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-779677(P05426) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-915744(P02454) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|agonist:Insulin was shown to increase or decrease GLUT4 protein interactions in specific cases.|comment:"Insulin decreased GLUT4 interactions with the following proteins: Q9ER30 (Sarcosin), P09527 (Rab-7), O88960 (N-ethylmaleimide sensitive), P09456 (PKA I regulatory subunit), P27881 (Hexokinase type II), P07872 (Acyl-coenzyme A oxidase), Q6DGF1 (Isocitrate dehydrogenase), Q9EQX9 (Ubiquitin-conjugating), Q63446 (Polyubiquitin), P24268 (Cathepsin D), Q91XW0 (Heat shock protein 86), Q5FVH0 (unknown), P58405 (Striatin 3), Q62667 (Major vault protein), Q66H50 (unknown), Q09167 (splicing factor), Q9JHU5 (Arfaptin 1)."|comment:"Insulin increased GLUT4 interaction with the following proteins:Q9Z1P2 (R-actinin-1), P45592 (Cofilin), Q9QXQ0 (R-actinin-4), P26473 (ADP-ribosylation factor), P26437 (ADP-ribosylation factor),   Q7TNP1 (Basigin 2), Q6P6R2 (Dihydrolipoamide dehydrogenase),   P04797 (GAPDH), Q63081 (Protein disulfide isomerase), P29457 (47 kDa heat shock protein), Q9R1J8 (Leprecan), O88638 (Putative eps protein),   Q64375 (Synaptonemal complex)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:NDPK - Interactions involving proteins containing InterPro domain IPR001564, Nucleoside diphosphate kinase, core.	taxid:10116(rat-l6)|taxid:10116(Rattus norvegicus)	-	2006/02/15	2021/11/30	rogid:PbFY2lfrty8yw40Jq7ShR7xfuV410116	rogid:+9jpJXGjYoI0ZssFhY4H/7IvIt410116	intact-crc:44F3A2176D02515F|rigid:9RVm0UBcqQF4k06RGKO89Bg16Q8	false	myc tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P19357	uniprotkb:Q9Z336	intact:EBI-915426|uniprotkb:P97900|ensembl:ENSRNOP00000023256	intact:EBI-920359|ensembl:ENSRNOP00000024656	psi-mi:glut4_rat(display_long)|uniprotkb:Glucose transporter type 4, insulin-responsive(gene name synonym)|uniprotkb:Slc2a4(gene name)|psi-mi:Slc2a4(display_short)|uniprotkb:Glut4(gene name synonym)	psi-mi:dylt1_rat(display_long)|uniprotkb:Dynlt1(gene name)|psi-mi:Dynlt1(display_short)|uniprotkb:Tctex1(gene name synonym)|uniprotkb:Tctex-1(gene name synonym)|uniprotkb:Activator of G-protein signaling 2(gene name synonym)|uniprotkb:Tctel1(gene name synonym)|uniprotkb:T-complex testis-specific protein 1 homolog(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Foster et al. (2006)	pubmed:16396496|mint:MINT-5218203	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-921030	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2711|refseq:NP_036883.1|refseq:XP_006246658.1|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007611"(learning or memory)|go:"GO:0007614"(short-term memory)|go:"GO:0007616"(long-term memory)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010021"(amylopectin biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031550"(positive regulation of brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044381"(glucose import in response to insulin stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046323"(glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0098694"(regulation of synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0098793"(presynapse)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002441("Glucose transporter, type 4 (GLUT4)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-189200|ensembl:ENSRNOG00000017226(gene)|ensembl:ENSRNOT00000023256(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)	rgd:620261|refseq:NP_112608.1|ensembl:ENSRNOG00000018207(gene)|ensembl:ENSRNOT00000024656(transcript)|go:"GO:0000132"(establishment of mitotic spindle orientation)|go:"GO:0005739"(mitochondrion)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005819"(spindle)|go:"GO:0005868"(cytoplasmic dynein complex)|go:"GO:0005881"(cytoplasmic microtubule)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008277"(regulation of G protein-coupled receptor signaling pathway)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0016358"(dendrite development)|go:"GO:0019060"(intracellular transport of viral protein in host cell)|go:"GO:0030027"(lamellipodium)|go:"GO:0035022"(positive regulation of Rac protein signal transduction)|go:"GO:0035795"(negative regulation of mitochondrial membrane permeability)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0043657"(host cell)|go:"GO:0044295"(axonal growth cone)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0050768"(negative regulation of neurogenesis)|go:"GO:0051301"(cell division)|go:"GO:0051493"(regulation of cytoskeleton organization)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0061564"(axon development)|go:"GO:0099503"(secretory vesicle)|interpro:IPR005334(Tctex-1)|interpro:IPR038586|reactome:R-RNO-6798695	-	-	-	caution:"The participant EBI-349571(P68370) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919386(Q7TP47) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920972(Q5XIP9) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-916419(P11980) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919578(Q8R491) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920554(Q5U3Z7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920647(Q5U2X8) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920585(Q7TP24) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-779677(P05426) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-915744(P02454) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|agonist:Insulin was shown to increase or decrease GLUT4 protein interactions in specific cases.|comment:"Insulin decreased GLUT4 interactions with the following proteins: Q9ER30 (Sarcosin), P09527 (Rab-7), O88960 (N-ethylmaleimide sensitive), P09456 (PKA I regulatory subunit), P27881 (Hexokinase type II), P07872 (Acyl-coenzyme A oxidase), Q6DGF1 (Isocitrate dehydrogenase), Q9EQX9 (Ubiquitin-conjugating), Q63446 (Polyubiquitin), P24268 (Cathepsin D), Q91XW0 (Heat shock protein 86), Q5FVH0 (unknown), P58405 (Striatin 3), Q62667 (Major vault protein), Q66H50 (unknown), Q09167 (splicing factor), Q9JHU5 (Arfaptin 1)."|comment:"Insulin increased GLUT4 interaction with the following proteins:Q9Z1P2 (R-actinin-1), P45592 (Cofilin), Q9QXQ0 (R-actinin-4), P26473 (ADP-ribosylation factor), P26437 (ADP-ribosylation factor),   Q7TNP1 (Basigin 2), Q6P6R2 (Dihydrolipoamide dehydrogenase),   P04797 (GAPDH), Q63081 (Protein disulfide isomerase), P29457 (47 kDa heat shock protein), Q9R1J8 (Leprecan), O88638 (Putative eps protein),   Q64375 (Synaptonemal complex)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:NDPK - Interactions involving proteins containing InterPro domain IPR001564, Nucleoside diphosphate kinase, core.	taxid:10116(rat-l6)|taxid:10116(Rattus norvegicus)	-	2006/02/15	2021/11/30	rogid:PbFY2lfrty8yw40Jq7ShR7xfuV410116	rogid:sq62mczk30/7gL8RkXNO2CBiTEQ10116	intact-crc:44F3A2176D02515F|rigid:9RVm0UBcqQF4k06RGKO89Bg16Q8	false	myc tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P19357	uniprotkb:Q9Z2X5	intact:EBI-915426|uniprotkb:P97900|ensembl:ENSRNOP00000023256	intact:EBI-920352|ensembl:ENSRNOP00000027428	psi-mi:glut4_rat(display_long)|uniprotkb:Glucose transporter type 4, insulin-responsive(gene name synonym)|uniprotkb:Slc2a4(gene name)|psi-mi:Slc2a4(display_short)|uniprotkb:Glut4(gene name synonym)	psi-mi:home3_rat(display_long)|uniprotkb:Homer3(gene name)|psi-mi:Homer3(display_short)|uniprotkb:Vesl3(gene name synonym)|uniprotkb:VASP/Ena-related gene up-regulated during seizure and LTP 3(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Foster et al. (2006)	pubmed:16396496|mint:MINT-5218203	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-921030	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2711|refseq:NP_036883.1|refseq:XP_006246658.1|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007611"(learning or memory)|go:"GO:0007614"(short-term memory)|go:"GO:0007616"(long-term memory)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010021"(amylopectin biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031550"(positive regulation of brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044381"(glucose import in response to insulin stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046323"(glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0098694"(regulation of synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0098793"(presynapse)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002441("Glucose transporter, type 4 (GLUT4)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-189200|ensembl:ENSRNOG00000017226(gene)|ensembl:ENSRNOT00000023256(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)	rgd:620706|refseq:NP_445762.1|refseq:XP_006252953.1|ensembl:ENSRNOG00000020229(gene)|ensembl:ENSRNOT00000027428(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007216"(G protein-coupled glutamate receptor signaling pathway)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030425"(dendrite)|go:"GO:0032703"(negative regulation of interleukin-2 production)|go:"GO:0035256"(G protein-coupled glutamate receptor binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0045178"(basal part of cell)|go:"GO:0070885"(negative regulation of calcineurin-NFAT signaling cascade)|go:"GO:0098962"(regulation of postsynaptic neurotransmitter receptor activity)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:2001256"(regulation of store-operated calcium entry)|interpro:IPR000697(EVH1)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR044100|mint:Q9Z2X5|reactome:R-RNO-6794361	-	-	-	caution:"The participant EBI-349571(P68370) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919386(Q7TP47) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920972(Q5XIP9) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-916419(P11980) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919578(Q8R491) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920554(Q5U3Z7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920647(Q5U2X8) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920585(Q7TP24) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-779677(P05426) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-915744(P02454) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|agonist:Insulin was shown to increase or decrease GLUT4 protein interactions in specific cases.|comment:"Insulin decreased GLUT4 interactions with the following proteins: Q9ER30 (Sarcosin), P09527 (Rab-7), O88960 (N-ethylmaleimide sensitive), P09456 (PKA I regulatory subunit), P27881 (Hexokinase type II), P07872 (Acyl-coenzyme A oxidase), Q6DGF1 (Isocitrate dehydrogenase), Q9EQX9 (Ubiquitin-conjugating), Q63446 (Polyubiquitin), P24268 (Cathepsin D), Q91XW0 (Heat shock protein 86), Q5FVH0 (unknown), P58405 (Striatin 3), Q62667 (Major vault protein), Q66H50 (unknown), Q09167 (splicing factor), Q9JHU5 (Arfaptin 1)."|comment:"Insulin increased GLUT4 interaction with the following proteins:Q9Z1P2 (R-actinin-1), P45592 (Cofilin), Q9QXQ0 (R-actinin-4), P26473 (ADP-ribosylation factor), P26437 (ADP-ribosylation factor),   Q7TNP1 (Basigin 2), Q6P6R2 (Dihydrolipoamide dehydrogenase),   P04797 (GAPDH), Q63081 (Protein disulfide isomerase), P29457 (47 kDa heat shock protein), Q9R1J8 (Leprecan), O88638 (Putative eps protein),   Q64375 (Synaptonemal complex)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:NDPK - Interactions involving proteins containing InterPro domain IPR001564, Nucleoside diphosphate kinase, core.	taxid:10116(rat-l6)|taxid:10116(Rattus norvegicus)	-	2006/02/15	2021/11/30	rogid:PbFY2lfrty8yw40Jq7ShR7xfuV410116	rogid:pJzod+zFtQHxU0N93UNrPzWttIU10116	intact-crc:44F3A2176D02515F|rigid:9RVm0UBcqQF4k06RGKO89Bg16Q8	false	myc tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P19357	uniprotkb:Q9Z2Q1	intact:EBI-915426|uniprotkb:P97900|ensembl:ENSRNOP00000023256	intact:EBI-920344|uniprotkb:Q5RKK4	psi-mi:glut4_rat(display_long)|uniprotkb:Glucose transporter type 4, insulin-responsive(gene name synonym)|uniprotkb:Slc2a4(gene name)|psi-mi:Slc2a4(display_short)|uniprotkb:Glut4(gene name synonym)	psi-mi:sc31a_rat(display_long)|uniprotkb:Sec31a(gene name)|psi-mi:Sec31a(display_short)|uniprotkb:Sec31l1(gene name synonym)|uniprotkb:SEC31-related protein A(gene name synonym)|uniprotkb:SEC31-like protein 1(gene name synonym)|uniprotkb:Vesicle-associated protein 1(gene name synonym)|uniprotkb:Vap1(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Foster et al. (2006)	pubmed:16396496|mint:MINT-5218203	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-921030	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2711|refseq:NP_036883.1|refseq:XP_006246658.1|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007611"(learning or memory)|go:"GO:0007614"(short-term memory)|go:"GO:0007616"(long-term memory)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010021"(amylopectin biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031550"(positive regulation of brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044381"(glucose import in response to insulin stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046323"(glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0098694"(regulation of synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0098793"(presynapse)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002441("Glucose transporter, type 4 (GLUT4)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-189200|ensembl:ENSRNOG00000017226(gene)|ensembl:ENSRNOT00000023256(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)	interpro:IPR024298|reactome:R-RNO-204005|reactome:R-RNO-2132295|reactome:R-RNO-983170|rgd:620233|refseq:NP_148981.1|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR001680(WD40 repeat)|refseq:XP_006250751.1|refseq:XP_006250752.1|go:"GO:0005198"(structural molecule activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0007029"(endoplasmic reticulum organization)|go:"GO:0030120"(vesicle coat)|go:"GO:0030127"(COPII vesicle coat)|go:"GO:0030134"(COPII-coated ER to Golgi transport vesicle)|go:"GO:0048306"(calcium-dependent protein binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051592"(response to calcium ion)|go:"GO:0070971"(endoplasmic reticulum exit site)|go:"GO:0090110"(COPII-coated vesicle cargo loading)|interpro:IPR036322|interpro:IPR040251	-	-	-	caution:"The participant EBI-349571(P68370) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919386(Q7TP47) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920972(Q5XIP9) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-916419(P11980) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919578(Q8R491) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920554(Q5U3Z7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920647(Q5U2X8) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920585(Q7TP24) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-779677(P05426) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-915744(P02454) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|agonist:Insulin was shown to increase or decrease GLUT4 protein interactions in specific cases.|comment:"Insulin decreased GLUT4 interactions with the following proteins: Q9ER30 (Sarcosin), P09527 (Rab-7), O88960 (N-ethylmaleimide sensitive), P09456 (PKA I regulatory subunit), P27881 (Hexokinase type II), P07872 (Acyl-coenzyme A oxidase), Q6DGF1 (Isocitrate dehydrogenase), Q9EQX9 (Ubiquitin-conjugating), Q63446 (Polyubiquitin), P24268 (Cathepsin D), Q91XW0 (Heat shock protein 86), Q5FVH0 (unknown), P58405 (Striatin 3), Q62667 (Major vault protein), Q66H50 (unknown), Q09167 (splicing factor), Q9JHU5 (Arfaptin 1)."|comment:"Insulin increased GLUT4 interaction with the following proteins:Q9Z1P2 (R-actinin-1), P45592 (Cofilin), Q9QXQ0 (R-actinin-4), P26473 (ADP-ribosylation factor), P26437 (ADP-ribosylation factor),   Q7TNP1 (Basigin 2), Q6P6R2 (Dihydrolipoamide dehydrogenase),   P04797 (GAPDH), Q63081 (Protein disulfide isomerase), P29457 (47 kDa heat shock protein), Q9R1J8 (Leprecan), O88638 (Putative eps protein),   Q64375 (Synaptonemal complex)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:NDPK - Interactions involving proteins containing InterPro domain IPR001564, Nucleoside diphosphate kinase, core.	taxid:10116(rat-l6)|taxid:10116(Rattus norvegicus)	-	2006/02/15	2021/11/30	rogid:PbFY2lfrty8yw40Jq7ShR7xfuV410116	rogid:IzsvmogIewqxkqnGIDVhk+z7vP010116	intact-crc:44F3A2176D02515F|rigid:9RVm0UBcqQF4k06RGKO89Bg16Q8	false	myc tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P19357	uniprotkb:Q9Z2L0	intact:EBI-915426|uniprotkb:P97900|ensembl:ENSRNOP00000023256	intact:EBI-920336|uniprotkb:A1L125|uniprotkb:Q3MHT8|uniprotkb:Q5M944|uniprotkb:Q5M972|uniprotkb:Q6IN28|uniprotkb:Q6P9W9|ensembl:ENSRNOP00000008477	psi-mi:glut4_rat(display_long)|uniprotkb:Glucose transporter type 4, insulin-responsive(gene name synonym)|uniprotkb:Slc2a4(gene name)|psi-mi:Slc2a4(display_short)|uniprotkb:Glut4(gene name synonym)	psi-mi:vdac1_rat(display_long)|uniprotkb:Vdac1(gene name)|psi-mi:Vdac1(display_short)|uniprotkb:Outer mitochondrial membrane protein porin 1(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Foster et al. (2006)	pubmed:16396496|mint:MINT-5218203	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-921030	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2711|refseq:NP_036883.1|refseq:XP_006246658.1|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007611"(learning or memory)|go:"GO:0007614"(short-term memory)|go:"GO:0007616"(long-term memory)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010021"(amylopectin biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031550"(positive regulation of brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044381"(glucose import in response to insulin stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046323"(glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0098694"(regulation of synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0098793"(presynapse)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002441("Glucose transporter, type 4 (GLUT4)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-189200|ensembl:ENSRNOG00000017226(gene)|ensembl:ENSRNOT00000023256(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)	rgd:621575|refseq:NP_112643.1|ensembl:ENSRNOG00000006375(gene)|ensembl:ENSRNOT00000008477(transcript)|go:"GO:0000166"(nucleotide binding)|go:"GO:0001662"(behavioral fear response)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042645"(mitochondrial nucleoid)|go:"GO:0042802"(identical protein binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045121"(membrane raft)|go:"GO:0097001"(ceramide binding)|go:"GO:0110099"(negative regulation of calcium import into the mitochondrion)|go:"GO:1901526"(positive regulation of mitophagy)|go:"GO:1903146"(regulation of autophagy of mitochondrion)|go:"GO:2000378"(negative regulation of reactive oxygen species metabolic process)|interpro:IPR001925(Porin, eukaryotic type)|interpro:IPR023614|interpro:IPR027246|interpro:IPR030270|mint:Q9Z2L0|reactome:R-RNO-5205685|reactome:R-RNO-5689880|reactome:R-RNO-70268|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0005253"(anion channel activity)|go:"GO:0005262"(calcium channel activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005757"(mitochondrial permeability transition pore complex)|go:"GO:0005886"(plasma membrane)|go:"GO:0006820"(anion transport)|go:"GO:0006851"(mitochondrial calcium ion transmembrane transport)|go:"GO:0006915"(apoptotic process)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007270"(neuron-neuron synaptic transmission)|go:"GO:0007612"(learning)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008308"(voltage-gated anion channel activity)|go:"GO:0015288"(porin activity)|go:"GO:0015485"(cholesterol binding)|go:"GO:0016020"(membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030855"(epithelial cell differentiation)|go:"GO:0031210"(phosphatidylcholine binding)|dip:DIP-37068N	-	-	-	caution:"The participant EBI-349571(P68370) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919386(Q7TP47) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920972(Q5XIP9) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-916419(P11980) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919578(Q8R491) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920554(Q5U3Z7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920647(Q5U2X8) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920585(Q7TP24) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-779677(P05426) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-915744(P02454) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|agonist:Insulin was shown to increase or decrease GLUT4 protein interactions in specific cases.|comment:"Insulin decreased GLUT4 interactions with the following proteins: Q9ER30 (Sarcosin), P09527 (Rab-7), O88960 (N-ethylmaleimide sensitive), P09456 (PKA I regulatory subunit), P27881 (Hexokinase type II), P07872 (Acyl-coenzyme A oxidase), Q6DGF1 (Isocitrate dehydrogenase), Q9EQX9 (Ubiquitin-conjugating), Q63446 (Polyubiquitin), P24268 (Cathepsin D), Q91XW0 (Heat shock protein 86), Q5FVH0 (unknown), P58405 (Striatin 3), Q62667 (Major vault protein), Q66H50 (unknown), Q09167 (splicing factor), Q9JHU5 (Arfaptin 1)."|comment:"Insulin increased GLUT4 interaction with the following proteins:Q9Z1P2 (R-actinin-1), P45592 (Cofilin), Q9QXQ0 (R-actinin-4), P26473 (ADP-ribosylation factor), P26437 (ADP-ribosylation factor),   Q7TNP1 (Basigin 2), Q6P6R2 (Dihydrolipoamide dehydrogenase),   P04797 (GAPDH), Q63081 (Protein disulfide isomerase), P29457 (47 kDa heat shock protein), Q9R1J8 (Leprecan), O88638 (Putative eps protein),   Q64375 (Synaptonemal complex)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:NDPK - Interactions involving proteins containing InterPro domain IPR001564, Nucleoside diphosphate kinase, core.	taxid:10116(rat-l6)|taxid:10116(Rattus norvegicus)	-	2006/02/15	2021/11/30	rogid:PbFY2lfrty8yw40Jq7ShR7xfuV410116	rogid:9tTXatzG8BVX217+t0HLppj0oAY10116	intact-crc:44F3A2176D02515F|rigid:9RVm0UBcqQF4k06RGKO89Bg16Q8	false	myc tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P19357	uniprotkb:Q6IRK9	intact:EBI-915426|uniprotkb:P97900|ensembl:ENSRNOP00000023256	intact:EBI-920327|uniprotkb:Q9JLV0|uniprotkb:Q9Z1Y1|ensembl:ENSRNOP00000008211	psi-mi:glut4_rat(display_long)|uniprotkb:Glucose transporter type 4, insulin-responsive(gene name synonym)|uniprotkb:Slc2a4(gene name)|psi-mi:Slc2a4(display_short)|uniprotkb:Glut4(gene name synonym)	psi-mi:cbpq_rat(display_long)|uniprotkb:Cpq(gene name)|psi-mi:Cpq(display_short)|uniprotkb:Hematopoietic lineage switch 2 related protein(gene name synonym)|uniprotkb:Liver annexin-like protein 1(gene name synonym)|uniprotkb:Pgcp(gene name synonym)|uniprotkb:Plasma glutamate carboxypeptidase(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Foster et al. (2006)	pubmed:16396496|mint:MINT-5218203	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-921030	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2711|refseq:NP_036883.1|refseq:XP_006246658.1|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007611"(learning or memory)|go:"GO:0007614"(short-term memory)|go:"GO:0007616"(long-term memory)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010021"(amylopectin biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031550"(positive regulation of brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044381"(glucose import in response to insulin stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046323"(glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0098694"(regulation of synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0098793"(presynapse)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002441("Glucose transporter, type 4 (GLUT4)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-189200|ensembl:ENSRNOG00000017226(gene)|ensembl:ENSRNOT00000023256(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)	rgd:628610|refseq:NP_113828.1|refseq:XP_008763639.1|ensembl:ENSRNOG00000005931(gene)|ensembl:ENSRNOT00000008211(transcript)|go:"GO:0004180"(carboxypeptidase activity)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0006508"(proteolysis)|go:"GO:0006590"(thyroid hormone generation)|go:"GO:0042246"(tissue regeneration)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043171"(peptide catabolic process)|go:"GO:0046872"(metal ion binding)|go:"GO:0070573"(metallodipeptidase activity)|interpro:IPR007484(Peptidase M28)|interpro:IPR039866	-	-	-	caution:"The participant EBI-349571(P68370) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919386(Q7TP47) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920972(Q5XIP9) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-916419(P11980) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919578(Q8R491) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920554(Q5U3Z7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920647(Q5U2X8) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920585(Q7TP24) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-779677(P05426) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-915744(P02454) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|agonist:Insulin was shown to increase or decrease GLUT4 protein interactions in specific cases.|comment:"Insulin decreased GLUT4 interactions with the following proteins: Q9ER30 (Sarcosin), P09527 (Rab-7), O88960 (N-ethylmaleimide sensitive), P09456 (PKA I regulatory subunit), P27881 (Hexokinase type II), P07872 (Acyl-coenzyme A oxidase), Q6DGF1 (Isocitrate dehydrogenase), Q9EQX9 (Ubiquitin-conjugating), Q63446 (Polyubiquitin), P24268 (Cathepsin D), Q91XW0 (Heat shock protein 86), Q5FVH0 (unknown), P58405 (Striatin 3), Q62667 (Major vault protein), Q66H50 (unknown), Q09167 (splicing factor), Q9JHU5 (Arfaptin 1)."|comment:"Insulin increased GLUT4 interaction with the following proteins:Q9Z1P2 (R-actinin-1), P45592 (Cofilin), Q9QXQ0 (R-actinin-4), P26473 (ADP-ribosylation factor), P26437 (ADP-ribosylation factor),   Q7TNP1 (Basigin 2), Q6P6R2 (Dihydrolipoamide dehydrogenase),   P04797 (GAPDH), Q63081 (Protein disulfide isomerase), P29457 (47 kDa heat shock protein), Q9R1J8 (Leprecan), O88638 (Putative eps protein),   Q64375 (Synaptonemal complex)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:NDPK - Interactions involving proteins containing InterPro domain IPR001564, Nucleoside diphosphate kinase, core.	taxid:10116(rat-l6)|taxid:10116(Rattus norvegicus)	-	2006/02/15	2021/11/30	rogid:PbFY2lfrty8yw40Jq7ShR7xfuV410116	rogid:zNJ4cdh8iGDBwZUu+Go/T9eNUdA10116	intact-crc:44F3A2176D02515F|rigid:9RVm0UBcqQF4k06RGKO89Bg16Q8	false	myc tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P19357	uniprotkb:Q9Z1X1	intact:EBI-915426|uniprotkb:P97900|ensembl:ENSRNOP00000023256	intact:EBI-920321|uniprotkb:Q3T1L3	psi-mi:glut4_rat(display_long)|uniprotkb:Glucose transporter type 4, insulin-responsive(gene name synonym)|uniprotkb:Slc2a4(gene name)|psi-mi:Slc2a4(display_short)|uniprotkb:Glut4(gene name synonym)	psi-mi:esyt1_rat(display_long)|uniprotkb:Esyt1(gene name)|psi-mi:Esyt1(display_short)|uniprotkb:Fam62a(gene name synonym)|uniprotkb:Membrane-bound C2 domain-containing protein(gene name synonym)|uniprotkb:vp115(gene name synonym)|uniprotkb:Mbc2(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Foster et al. (2006)	pubmed:16396496|mint:MINT-5218203	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-921030	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2711|refseq:NP_036883.1|refseq:XP_006246658.1|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007611"(learning or memory)|go:"GO:0007614"(short-term memory)|go:"GO:0007616"(long-term memory)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010021"(amylopectin biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031550"(positive regulation of brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044381"(glucose import in response to insulin stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046323"(glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0098694"(regulation of synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0098793"(presynapse)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002441("Glucose transporter, type 4 (GLUT4)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-189200|ensembl:ENSRNOG00000017226(gene)|ensembl:ENSRNOT00000023256(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)	rgd:3053|refseq:NP_058945.2|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR031468|go:"GO:0005509"(calcium ion binding)|go:"GO:0005544"(calcium-dependent phospholipid binding)|go:"GO:0006869"(lipid transport)|go:"GO:0008429"(phosphatidylethanolamine binding)|go:"GO:0030176"(integral component of endoplasmic reticulum membrane)|go:"GO:0031210"(phosphatidylcholine binding)|go:"GO:0031227"(intrinsic component of endoplasmic reticulum membrane)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0035091"(phosphatidylinositol binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0061817"(endoplasmic reticulum-plasma membrane tethering)|reactome:R-RNO-9013149|reactome:R-RNO-9013404|reactome:R-RNO-9013405|reactome:R-RNO-9013408|reactome:R-RNO-9013423|reactome:R-RNO-9035034|interpro:IPR037733|interpro:IPR037749|interpro:IPR037752|interpro:IPR035892|interpro:IPR039010|reactome:R-RNO-1660662	-	-	-	caution:"The participant EBI-349571(P68370) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919386(Q7TP47) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920972(Q5XIP9) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-916419(P11980) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919578(Q8R491) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920554(Q5U3Z7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920647(Q5U2X8) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920585(Q7TP24) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-779677(P05426) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-915744(P02454) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|agonist:Insulin was shown to increase or decrease GLUT4 protein interactions in specific cases.|comment:"Insulin decreased GLUT4 interactions with the following proteins: Q9ER30 (Sarcosin), P09527 (Rab-7), O88960 (N-ethylmaleimide sensitive), P09456 (PKA I regulatory subunit), P27881 (Hexokinase type II), P07872 (Acyl-coenzyme A oxidase), Q6DGF1 (Isocitrate dehydrogenase), Q9EQX9 (Ubiquitin-conjugating), Q63446 (Polyubiquitin), P24268 (Cathepsin D), Q91XW0 (Heat shock protein 86), Q5FVH0 (unknown), P58405 (Striatin 3), Q62667 (Major vault protein), Q66H50 (unknown), Q09167 (splicing factor), Q9JHU5 (Arfaptin 1)."|comment:"Insulin increased GLUT4 interaction with the following proteins:Q9Z1P2 (R-actinin-1), P45592 (Cofilin), Q9QXQ0 (R-actinin-4), P26473 (ADP-ribosylation factor), P26437 (ADP-ribosylation factor),   Q7TNP1 (Basigin 2), Q6P6R2 (Dihydrolipoamide dehydrogenase),   P04797 (GAPDH), Q63081 (Protein disulfide isomerase), P29457 (47 kDa heat shock protein), Q9R1J8 (Leprecan), O88638 (Putative eps protein),   Q64375 (Synaptonemal complex)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:NDPK - Interactions involving proteins containing InterPro domain IPR001564, Nucleoside diphosphate kinase, core.	taxid:10116(rat-l6)|taxid:10116(Rattus norvegicus)	-	2006/02/15	2021/11/30	rogid:PbFY2lfrty8yw40Jq7ShR7xfuV410116	rogid:mgTDcM+D8W+tzRiki3223qss5rA10116	intact-crc:44F3A2176D02515F|rigid:9RVm0UBcqQF4k06RGKO89Bg16Q8	false	myc tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P19357	uniprotkb:Q9Z1W6	intact:EBI-915426|uniprotkb:P97900|ensembl:ENSRNOP00000023256	intact:EBI-920297|ensembl:ENSRNOP00000009989	psi-mi:glut4_rat(display_long)|uniprotkb:Glucose transporter type 4, insulin-responsive(gene name synonym)|uniprotkb:Slc2a4(gene name)|psi-mi:Slc2a4(display_short)|uniprotkb:Glut4(gene name synonym)	psi-mi:lyric_rat(display_long)|uniprotkb:Mtdh(gene name)|psi-mi:Mtdh(display_short)|uniprotkb:Lyric(gene name synonym)|uniprotkb:Lysine-rich CEACAM1 co-isolated protein(gene name synonym)|uniprotkb:Metastasis adhesion protein(gene name synonym)|uniprotkb:Metadherin(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Foster et al. (2006)	pubmed:16396496|mint:MINT-5218203	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-921030	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2711|refseq:NP_036883.1|refseq:XP_006246658.1|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007611"(learning or memory)|go:"GO:0007614"(short-term memory)|go:"GO:0007616"(long-term memory)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010021"(amylopectin biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031550"(positive regulation of brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044381"(glucose import in response to insulin stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046323"(glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0098694"(regulation of synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0098793"(presynapse)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002441("Glucose transporter, type 4 (GLUT4)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-189200|ensembl:ENSRNOG00000017226(gene)|ensembl:ENSRNOT00000023256(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)	rgd:620992|refseq:NP_596889.1|interpro:IPR031402|go:"GO:0003712"(transcription coregulator activity)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0031965"(nuclear membrane)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0046581"(intercellular canaliculus)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051059"(NF-kappaB binding)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070830"(bicellular tight junction assembly)|ensembl:ENSRNOG00000006870(gene)|ensembl:ENSRNOT00000009989(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001650"(fibrillar center)	-	-	-	caution:"The participant EBI-349571(P68370) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919386(Q7TP47) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920972(Q5XIP9) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-916419(P11980) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919578(Q8R491) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920554(Q5U3Z7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920647(Q5U2X8) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920585(Q7TP24) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-779677(P05426) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-915744(P02454) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|agonist:Insulin was shown to increase or decrease GLUT4 protein interactions in specific cases.|comment:"Insulin decreased GLUT4 interactions with the following proteins: Q9ER30 (Sarcosin), P09527 (Rab-7), O88960 (N-ethylmaleimide sensitive), P09456 (PKA I regulatory subunit), P27881 (Hexokinase type II), P07872 (Acyl-coenzyme A oxidase), Q6DGF1 (Isocitrate dehydrogenase), Q9EQX9 (Ubiquitin-conjugating), Q63446 (Polyubiquitin), P24268 (Cathepsin D), Q91XW0 (Heat shock protein 86), Q5FVH0 (unknown), P58405 (Striatin 3), Q62667 (Major vault protein), Q66H50 (unknown), Q09167 (splicing factor), Q9JHU5 (Arfaptin 1)."|comment:"Insulin increased GLUT4 interaction with the following proteins:Q9Z1P2 (R-actinin-1), P45592 (Cofilin), Q9QXQ0 (R-actinin-4), P26473 (ADP-ribosylation factor), P26437 (ADP-ribosylation factor),   Q7TNP1 (Basigin 2), Q6P6R2 (Dihydrolipoamide dehydrogenase),   P04797 (GAPDH), Q63081 (Protein disulfide isomerase), P29457 (47 kDa heat shock protein), Q9R1J8 (Leprecan), O88638 (Putative eps protein),   Q64375 (Synaptonemal complex)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:NDPK - Interactions involving proteins containing InterPro domain IPR001564, Nucleoside diphosphate kinase, core.	taxid:10116(rat-l6)|taxid:10116(Rattus norvegicus)	-	2006/02/15	2021/11/30	rogid:PbFY2lfrty8yw40Jq7ShR7xfuV410116	rogid:hOtI+TsuCiFxtwXImR4ILL5Kp/U10116	intact-crc:44F3A2176D02515F|rigid:9RVm0UBcqQF4k06RGKO89Bg16Q8	false	myc tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P19357	uniprotkb:Q9Z1P2	intact:EBI-915426|uniprotkb:P97900|ensembl:ENSRNOP00000023256	intact:EBI-920286|ensembl:ENSRNOP00000069598	psi-mi:glut4_rat(display_long)|uniprotkb:Glucose transporter type 4, insulin-responsive(gene name synonym)|uniprotkb:Slc2a4(gene name)|psi-mi:Slc2a4(display_short)|uniprotkb:Glut4(gene name synonym)	psi-mi:actn1_rat(display_long)|uniprotkb:Actn1(gene name)|psi-mi:Actn1(display_short)|uniprotkb:Alpha-actinin cytoskeletal isoform(gene name synonym)|uniprotkb:Non-muscle alpha-actinin-1(gene name synonym)|uniprotkb:F-actin cross-linking protein(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Foster et al. (2006)	pubmed:16396496|mint:MINT-5218203	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-921030	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2711|refseq:NP_036883.1|refseq:XP_006246658.1|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007611"(learning or memory)|go:"GO:0007614"(short-term memory)|go:"GO:0007616"(long-term memory)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010021"(amylopectin biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031550"(positive regulation of brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044381"(glucose import in response to insulin stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046323"(glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0098694"(regulation of synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0098793"(presynapse)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002441("Glucose transporter, type 4 (GLUT4)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-189200|ensembl:ENSRNOG00000017226(gene)|ensembl:ENSRNOT00000023256(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)	rgd:70907|refseq:NP_112267.1|ensembl:ENSRNOG00000056756(gene)|ensembl:ENSRNOT00000088795(transcript)|go:"GO:0001725"(stress fiber)|go:"GO:0001726"(ruffle)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005519"(cytoskeletal regulatory protein binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005903"(brush border)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005916"(fascia adherens)|go:"GO:0005925"(focal adhesion)|go:"GO:0007015"(actin filament organization)|go:"GO:0017166"(vinculin binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030054"(cell junction)|go:"GO:0030220"(platelet formation)|go:"GO:0030374"(nuclear receptor coactivator activity)|go:"GO:0036344"(platelet morphogenesis)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042995"(cell projection)|go:"GO:0043197"(dendritic spine)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0048041"(focal adhesion assembly)|go:"GO:0051015"(actin filament binding)|go:"GO:0051017"(actin filament bundle assembly)|go:"GO:0051271"(negative regulation of cellular component movement)|go:"GO:0051639"(actin filament network formation)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099186"(structural constituent of postsynapse)|interpro:IPR001589(Actinin-type, actin-binding, conserved site)|interpro:IPR001715(Calponin-like actin-binding)|interpro:IPR002017(Spectrin repeat)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR011992(EF-Hand type)|interpro:IPR014837(EF-hand, Ca insensitive)|interpro:IPR018159|interpro:IPR018247|interpro:IPR036872|mint:Q9Z1P2|reactome:R-RNO-114608|reactome:R-RNO-446388|reactome:R-RNO-9013405|reactome:R-RNO-9013418|reactome:R-RNO-9035034	-	-	-	caution:"The participant EBI-349571(P68370) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919386(Q7TP47) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920972(Q5XIP9) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-916419(P11980) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919578(Q8R491) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920554(Q5U3Z7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920647(Q5U2X8) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920585(Q7TP24) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-779677(P05426) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-915744(P02454) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|agonist:Insulin was shown to increase or decrease GLUT4 protein interactions in specific cases.|comment:"Insulin decreased GLUT4 interactions with the following proteins: Q9ER30 (Sarcosin), P09527 (Rab-7), O88960 (N-ethylmaleimide sensitive), P09456 (PKA I regulatory subunit), P27881 (Hexokinase type II), P07872 (Acyl-coenzyme A oxidase), Q6DGF1 (Isocitrate dehydrogenase), Q9EQX9 (Ubiquitin-conjugating), Q63446 (Polyubiquitin), P24268 (Cathepsin D), Q91XW0 (Heat shock protein 86), Q5FVH0 (unknown), P58405 (Striatin 3), Q62667 (Major vault protein), Q66H50 (unknown), Q09167 (splicing factor), Q9JHU5 (Arfaptin 1)."|comment:"Insulin increased GLUT4 interaction with the following proteins:Q9Z1P2 (R-actinin-1), P45592 (Cofilin), Q9QXQ0 (R-actinin-4), P26473 (ADP-ribosylation factor), P26437 (ADP-ribosylation factor),   Q7TNP1 (Basigin 2), Q6P6R2 (Dihydrolipoamide dehydrogenase),   P04797 (GAPDH), Q63081 (Protein disulfide isomerase), P29457 (47 kDa heat shock protein), Q9R1J8 (Leprecan), O88638 (Putative eps protein),   Q64375 (Synaptonemal complex)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:NDPK - Interactions involving proteins containing InterPro domain IPR001564, Nucleoside diphosphate kinase, core.	taxid:10116(rat-l6)|taxid:10116(Rattus norvegicus)	-	2006/02/15	2021/11/30	rogid:PbFY2lfrty8yw40Jq7ShR7xfuV410116	rogid:e8zdF7HOx12sx9WE9oJe6tk9br810116	intact-crc:44F3A2176D02515F|rigid:9RVm0UBcqQF4k06RGKO89Bg16Q8	false	myc tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P19357	uniprotkb:Q9Z1E1	intact:EBI-915426|uniprotkb:P97900|ensembl:ENSRNOP00000023256	intact:EBI-920268|uniprotkb:Q9Z1E2|ensembl:ENSRNOP00000001098|ensembl:ENSRNOP00000071275	psi-mi:glut4_rat(display_long)|uniprotkb:Glucose transporter type 4, insulin-responsive(gene name synonym)|uniprotkb:Slc2a4(gene name)|psi-mi:Slc2a4(display_short)|uniprotkb:Glut4(gene name synonym)	psi-mi:flot1_rat(display_long)|uniprotkb:Flot1(gene name)|psi-mi:Flot1(display_short)|uniprotkb:Reg2(gene name synonym)|uniprotkb:Reggie-2(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Foster et al. (2006)	pubmed:16396496|mint:MINT-5218203	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-921030	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2711|refseq:NP_036883.1|refseq:XP_006246658.1|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007611"(learning or memory)|go:"GO:0007614"(short-term memory)|go:"GO:0007616"(long-term memory)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010021"(amylopectin biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031550"(positive regulation of brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044381"(glucose import in response to insulin stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046323"(glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0098694"(regulation of synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0098793"(presynapse)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002441("Glucose transporter, type 4 (GLUT4)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-189200|ensembl:ENSRNOG00000017226(gene)|ensembl:ENSRNOT00000023256(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)	rgd:70991|refseq:NP_073192.2|refseq:XP_006256086.1|ensembl:ENSRNOG00000000826(gene)|ensembl:ENSRNOT00000001098(transcript)|ensembl:ENSRNOT00000090039(transcript)|go:"GO:0001765"(membrane raft assembly)|go:"GO:0001819"(positive regulation of cytokine production)|go:"GO:0001931"(uropod)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002020"(protease binding)|go:"GO:0002090"(regulation of receptor internalization)|go:"GO:0005768"(endosome)|go:"GO:0005769"(early endosome)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0005886"(plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005912"(adherens junction)|go:"GO:0007409"(axonogenesis)|go:"GO:0008180"(COP9 signalosome)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0016020"(membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016600"(flotillin complex)|go:"GO:0022617"(extracellular matrix disassembly)|go:"GO:0030027"(lamellipodium)|go:"GO:0030864"(cortical actin cytoskeleton)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032226"(positive regulation of synaptic transmission, dopaminergic)|go:"GO:0032728"(positive regulation of interferon-beta production)|go:"GO:0033227"(dsRNA transport)|go:"GO:0034116"(positive regulation of heterotypic cell-cell adhesion)|go:"GO:0034141"(positive regulation of toll-like receptor 3 signaling pathway)|go:"GO:0034451"(centriolar satellite)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0035023"(regulation of Rho protein signal transduction)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0042383"(sarcolemma)|go:"GO:0042470"(melanosome)|go:"GO:0044291"(cell-cell contact zone)|go:"GO:0044853"(plasma membrane raft)|go:"GO:0044854"(plasma membrane raft assembly)|go:"GO:0045121"(membrane raft)|go:"GO:0045202"(synapse)|go:"GO:0045807"(positive regulation of endocytosis)|go:"GO:0048643"(positive regulation of skeletal muscle tissue development)|go:"GO:0048786"(presynaptic active zone)|go:"GO:0050821"(protein stabilization)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051580"(regulation of neurotransmitter uptake)|go:"GO:0060355"(positive regulation of cell adhesion molecule production)|go:"GO:0070528"(protein kinase C signaling)|go:"GO:0071360"(cellular response to exogenous dsRNA)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0098691"(dopaminergic synapse)|go:"GO:0098793"(presynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0098982"(GABA-ergic synapse)|go:"GO:1901741"(positive regulation of myoblast fusion)|go:"GO:1901890"(positive regulation of cell junction assembly)|go:"GO:1903044"(protein localization to membrane raft)|go:"GO:2000049"(positive regulation of cell-cell adhesion mediated by cadherin)|interpro:IPR001107(Band 7 protein)|interpro:IPR027705|interpro:IPR031905|interpro:IPR036013|mint:Q9Z1E1|reactome:R-RNO-5213460|reactome:R-RNO-5675482|reactome:R-RNO-8849932|reactome:R-RNO-8980692|reactome:R-RNO-9013026|reactome:R-RNO-9013106	-	-	-	caution:"The participant EBI-349571(P68370) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919386(Q7TP47) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920972(Q5XIP9) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-916419(P11980) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919578(Q8R491) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920554(Q5U3Z7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920647(Q5U2X8) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920585(Q7TP24) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-779677(P05426) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-915744(P02454) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|agonist:Insulin was shown to increase or decrease GLUT4 protein interactions in specific cases.|comment:"Insulin decreased GLUT4 interactions with the following proteins: Q9ER30 (Sarcosin), P09527 (Rab-7), O88960 (N-ethylmaleimide sensitive), P09456 (PKA I regulatory subunit), P27881 (Hexokinase type II), P07872 (Acyl-coenzyme A oxidase), Q6DGF1 (Isocitrate dehydrogenase), Q9EQX9 (Ubiquitin-conjugating), Q63446 (Polyubiquitin), P24268 (Cathepsin D), Q91XW0 (Heat shock protein 86), Q5FVH0 (unknown), P58405 (Striatin 3), Q62667 (Major vault protein), Q66H50 (unknown), Q09167 (splicing factor), Q9JHU5 (Arfaptin 1)."|comment:"Insulin increased GLUT4 interaction with the following proteins:Q9Z1P2 (R-actinin-1), P45592 (Cofilin), Q9QXQ0 (R-actinin-4), P26473 (ADP-ribosylation factor), P26437 (ADP-ribosylation factor),   Q7TNP1 (Basigin 2), Q6P6R2 (Dihydrolipoamide dehydrogenase),   P04797 (GAPDH), Q63081 (Protein disulfide isomerase), P29457 (47 kDa heat shock protein), Q9R1J8 (Leprecan), O88638 (Putative eps protein),   Q64375 (Synaptonemal complex)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:NDPK - Interactions involving proteins containing InterPro domain IPR001564, Nucleoside diphosphate kinase, core.	taxid:10116(rat-l6)|taxid:10116(Rattus norvegicus)	-	2006/02/15	2021/11/30	rogid:PbFY2lfrty8yw40Jq7ShR7xfuV410116	rogid:zQd1GziJRcfE7u4/b/800Dotg8A10116	intact-crc:44F3A2176D02515F|rigid:9RVm0UBcqQF4k06RGKO89Bg16Q8	false	myc tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P19357	uniprotkb:Q9Z0V6	intact:EBI-915426|uniprotkb:P97900|ensembl:ENSRNOP00000023256	intact:EBI-920251|uniprotkb:Q6P9W3	psi-mi:glut4_rat(display_long)|uniprotkb:Glucose transporter type 4, insulin-responsive(gene name synonym)|uniprotkb:Slc2a4(gene name)|psi-mi:Slc2a4(display_short)|uniprotkb:Glut4(gene name synonym)	psi-mi:prdx3_rat(display_long)|uniprotkb:Prdx3(gene name)|psi-mi:Prdx3(display_short)|uniprotkb:Peroxiredoxin-3(gene name synonym)|uniprotkb:PRx III(gene name synonym)|uniprotkb:Thioredoxin-dependent peroxiredoxin 3(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Foster et al. (2006)	pubmed:16396496|mint:MINT-5218203	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-921030	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2711|refseq:NP_036883.1|refseq:XP_006246658.1|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007611"(learning or memory)|go:"GO:0007614"(short-term memory)|go:"GO:0007616"(long-term memory)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010021"(amylopectin biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031550"(positive regulation of brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044381"(glucose import in response to insulin stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046323"(glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0098694"(regulation of synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0098793"(presynapse)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002441("Glucose transporter, type 4 (GLUT4)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-189200|ensembl:ENSRNOG00000017226(gene)|ensembl:ENSRNOT00000023256(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)	interpro:IPR013766(Thioredoxin domain)|rgd:620040|refseq:NP_071985.1|interpro:IPR000866(Alkyl hydroperoxide reductase/ Thiol specific antioxidant/ Mal allergen)|interpro:IPR019479|go:"GO:0001893"(maternal placenta development)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005769"(early endosome)|go:"GO:0005829"(cytosol)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008379"(thioredoxin peroxidase activity)|go:"GO:0018171"(peptidyl-cysteine oxidation)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030099"(myeloid cell differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033673"(negative regulation of kinase activity)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0034614"(cellular response to reactive oxygen species)|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0042744"(hydrogen peroxide catabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0043027"(cysteine-type endopeptidase inhibitor activity involved in apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0045454"(cell redox homeostasis)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051881"(regulation of mitochondrial membrane potential)|reactome:R-RNO-3299685|mint:Q9Z0V6|interpro:IPR036249	-	-	-	caution:"The participant EBI-349571(P68370) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919386(Q7TP47) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920972(Q5XIP9) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-916419(P11980) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919578(Q8R491) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920554(Q5U3Z7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920647(Q5U2X8) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920585(Q7TP24) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-779677(P05426) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-915744(P02454) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|agonist:Insulin was shown to increase or decrease GLUT4 protein interactions in specific cases.|comment:"Insulin decreased GLUT4 interactions with the following proteins: Q9ER30 (Sarcosin), P09527 (Rab-7), O88960 (N-ethylmaleimide sensitive), P09456 (PKA I regulatory subunit), P27881 (Hexokinase type II), P07872 (Acyl-coenzyme A oxidase), Q6DGF1 (Isocitrate dehydrogenase), Q9EQX9 (Ubiquitin-conjugating), Q63446 (Polyubiquitin), P24268 (Cathepsin D), Q91XW0 (Heat shock protein 86), Q5FVH0 (unknown), P58405 (Striatin 3), Q62667 (Major vault protein), Q66H50 (unknown), Q09167 (splicing factor), Q9JHU5 (Arfaptin 1)."|comment:"Insulin increased GLUT4 interaction with the following proteins:Q9Z1P2 (R-actinin-1), P45592 (Cofilin), Q9QXQ0 (R-actinin-4), P26473 (ADP-ribosylation factor), P26437 (ADP-ribosylation factor),   Q7TNP1 (Basigin 2), Q6P6R2 (Dihydrolipoamide dehydrogenase),   P04797 (GAPDH), Q63081 (Protein disulfide isomerase), P29457 (47 kDa heat shock protein), Q9R1J8 (Leprecan), O88638 (Putative eps protein),   Q64375 (Synaptonemal complex)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:NDPK - Interactions involving proteins containing InterPro domain IPR001564, Nucleoside diphosphate kinase, core.	taxid:10116(rat-l6)|taxid:10116(Rattus norvegicus)	-	2006/02/15	2021/11/30	rogid:PbFY2lfrty8yw40Jq7ShR7xfuV410116	rogid:r6hzYY+4LtEHXWoAiTM35SxMtGQ10116	intact-crc:44F3A2176D02515F|rigid:9RVm0UBcqQF4k06RGKO89Bg16Q8	false	myc tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P19357	uniprotkb:Q9Z0V5	intact:EBI-915426|uniprotkb:P97900|ensembl:ENSRNOP00000023256	intact:EBI-920242|ensembl:ENSRNOP00000005014	psi-mi:glut4_rat(display_long)|uniprotkb:Glucose transporter type 4, insulin-responsive(gene name synonym)|uniprotkb:Slc2a4(gene name)|psi-mi:Slc2a4(display_short)|uniprotkb:Glut4(gene name synonym)	psi-mi:prdx4_rat(display_long)|uniprotkb:Prdx4(gene name)|psi-mi:Prdx4(display_short)|uniprotkb:Rno2CysPrx04(gene name synonym)|uniprotkb:Thioredoxin-dependent peroxiredoxin 4(gene name synonym)|uniprotkb:Peroxiredoxin IV(gene name synonym)|uniprotkb:Thioredoxin peroxidase AO372(gene name synonym)|uniprotkb:Thioredoxin-dependent peroxide reductase A0372(gene name synonym)|uniprotkb:Antioxidant enzyme AOE372(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Foster et al. (2006)	pubmed:16396496|mint:MINT-5218203	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-921030	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2711|refseq:NP_036883.1|refseq:XP_006246658.1|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007611"(learning or memory)|go:"GO:0007614"(short-term memory)|go:"GO:0007616"(long-term memory)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010021"(amylopectin biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031550"(positive regulation of brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044381"(glucose import in response to insulin stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046323"(glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0098694"(regulation of synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0098793"(presynapse)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002441("Glucose transporter, type 4 (GLUT4)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-189200|ensembl:ENSRNOG00000017226(gene)|ensembl:ENSRNOT00000023256(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)	rgd:620043|refseq:NP_445964.1|ensembl:ENSRNOG00000003763(gene)|ensembl:ENSRNOT00000005014(transcript)|go:"GO:0004601"(peroxidase activity)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005790"(smooth endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0007283"(spermatogenesis)|go:"GO:0008584"(male gonad development)|go:"GO:0018401"(peptidyl-proline hydroxylation to 4-hydroxy-L-proline)|go:"GO:0022417"(protein maturation by protein folding)|go:"GO:0030198"(extracellular matrix organization)|go:"GO:0042802"(identical protein binding)|go:"GO:0045454"(cell redox homeostasis)|go:"GO:0051920"(peroxiredoxin activity)|go:"GO:0072593"(reactive oxygen species metabolic process)|go:"GO:2000255"(negative regulation of male germ cell proliferation)|interpro:IPR000866(Alkyl hydroperoxide reductase/ Thiol specific antioxidant/ Mal allergen)|interpro:IPR013766(Thioredoxin domain)|interpro:IPR019479|interpro:IPR036249|reactome:R-RNO-6798695	-	-	-	caution:"The participant EBI-349571(P68370) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919386(Q7TP47) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920972(Q5XIP9) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-916419(P11980) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919578(Q8R491) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920554(Q5U3Z7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920647(Q5U2X8) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920585(Q7TP24) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-779677(P05426) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-915744(P02454) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|agonist:Insulin was shown to increase or decrease GLUT4 protein interactions in specific cases.|comment:"Insulin decreased GLUT4 interactions with the following proteins: Q9ER30 (Sarcosin), P09527 (Rab-7), O88960 (N-ethylmaleimide sensitive), P09456 (PKA I regulatory subunit), P27881 (Hexokinase type II), P07872 (Acyl-coenzyme A oxidase), Q6DGF1 (Isocitrate dehydrogenase), Q9EQX9 (Ubiquitin-conjugating), Q63446 (Polyubiquitin), P24268 (Cathepsin D), Q91XW0 (Heat shock protein 86), Q5FVH0 (unknown), P58405 (Striatin 3), Q62667 (Major vault protein), Q66H50 (unknown), Q09167 (splicing factor), Q9JHU5 (Arfaptin 1)."|comment:"Insulin increased GLUT4 interaction with the following proteins:Q9Z1P2 (R-actinin-1), P45592 (Cofilin), Q9QXQ0 (R-actinin-4), P26473 (ADP-ribosylation factor), P26437 (ADP-ribosylation factor),   Q7TNP1 (Basigin 2), Q6P6R2 (Dihydrolipoamide dehydrogenase),   P04797 (GAPDH), Q63081 (Protein disulfide isomerase), P29457 (47 kDa heat shock protein), Q9R1J8 (Leprecan), O88638 (Putative eps protein),   Q64375 (Synaptonemal complex)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:NDPK - Interactions involving proteins containing InterPro domain IPR001564, Nucleoside diphosphate kinase, core.	taxid:10116(rat-l6)|taxid:10116(Rattus norvegicus)	-	2006/02/15	2021/11/30	rogid:PbFY2lfrty8yw40Jq7ShR7xfuV410116	rogid:3Oi90941+tXQ+wCOleurOvI0GAs10116	intact-crc:44F3A2176D02515F|rigid:9RVm0UBcqQF4k06RGKO89Bg16Q8	false	myc tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P19357	uniprotkb:Q9Z0U8	intact:EBI-915426|uniprotkb:P97900|ensembl:ENSRNOP00000023256	intact:EBI-920231	psi-mi:glut4_rat(display_long)|uniprotkb:Glucose transporter type 4, insulin-responsive(gene name synonym)|uniprotkb:Slc2a4(gene name)|psi-mi:Slc2a4(display_short)|uniprotkb:Glut4(gene name synonym)	psi-mi:q9z0u8_rat(display_long)|uniprotkb:pRM10(gene name)|psi-mi:pRM10(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Foster et al. (2006)	pubmed:16396496|mint:MINT-5218203	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-921030	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2711|refseq:NP_036883.1|refseq:XP_006246658.1|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007611"(learning or memory)|go:"GO:0007614"(short-term memory)|go:"GO:0007616"(long-term memory)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010021"(amylopectin biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031550"(positive regulation of brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044381"(glucose import in response to insulin stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046323"(glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0098694"(regulation of synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0098793"(presynapse)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002441("Glucose transporter, type 4 (GLUT4)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-189200|ensembl:ENSRNOG00000017226(gene)|ensembl:ENSRNOT00000023256(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)	interpro:IPR012956(CBF, N-terminal)|interpro:IPR000504(RNA recognition motif, RNP-1)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|mint:Q9Z0U8|interpro:IPR034846|interpro:IPR035979	-	-	-	caution:"The participant EBI-349571(P68370) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919386(Q7TP47) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920972(Q5XIP9) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-916419(P11980) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919578(Q8R491) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920554(Q5U3Z7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920647(Q5U2X8) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920585(Q7TP24) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-779677(P05426) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-915744(P02454) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|agonist:Insulin was shown to increase or decrease GLUT4 protein interactions in specific cases.|comment:"Insulin decreased GLUT4 interactions with the following proteins: Q9ER30 (Sarcosin), P09527 (Rab-7), O88960 (N-ethylmaleimide sensitive), P09456 (PKA I regulatory subunit), P27881 (Hexokinase type II), P07872 (Acyl-coenzyme A oxidase), Q6DGF1 (Isocitrate dehydrogenase), Q9EQX9 (Ubiquitin-conjugating), Q63446 (Polyubiquitin), P24268 (Cathepsin D), Q91XW0 (Heat shock protein 86), Q5FVH0 (unknown), P58405 (Striatin 3), Q62667 (Major vault protein), Q66H50 (unknown), Q09167 (splicing factor), Q9JHU5 (Arfaptin 1)."|comment:"Insulin increased GLUT4 interaction with the following proteins:Q9Z1P2 (R-actinin-1), P45592 (Cofilin), Q9QXQ0 (R-actinin-4), P26473 (ADP-ribosylation factor), P26437 (ADP-ribosylation factor),   Q7TNP1 (Basigin 2), Q6P6R2 (Dihydrolipoamide dehydrogenase),   P04797 (GAPDH), Q63081 (Protein disulfide isomerase), P29457 (47 kDa heat shock protein), Q9R1J8 (Leprecan), O88638 (Putative eps protein),   Q64375 (Synaptonemal complex)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:NDPK - Interactions involving proteins containing InterPro domain IPR001564, Nucleoside diphosphate kinase, core.	taxid:10116(rat-l6)|taxid:10116(Rattus norvegicus)	-	2006/02/15	2021/11/30	rogid:PbFY2lfrty8yw40Jq7ShR7xfuV410116	rogid:NnMOoh9nIimFkA2Hsb3gFyMbkT010116	intact-crc:44F3A2176D02515F|rigid:9RVm0UBcqQF4k06RGKO89Bg16Q8	false	myc tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P19357	uniprotkb:Q9WVK7	intact:EBI-915426|uniprotkb:P97900|ensembl:ENSRNOP00000023256	intact:EBI-920220|ensembl:ENSRNOP00000014658	psi-mi:glut4_rat(display_long)|uniprotkb:Glucose transporter type 4, insulin-responsive(gene name synonym)|uniprotkb:Slc2a4(gene name)|psi-mi:Slc2a4(display_short)|uniprotkb:Glut4(gene name synonym)	psi-mi:hcdh_rat(display_long)|uniprotkb:Hadh(gene name)|psi-mi:Hadh(display_short)|uniprotkb:Had(gene name synonym)|uniprotkb:Schad(gene name synonym)|uniprotkb:Short-chain 3-hydroxyacyl-CoA dehydrogenase(gene name synonym)|uniprotkb:Medium and short-chain L-3-hydroxyacyl-coenzyme A dehydrogenase(gene name synonym)|uniprotkb:Hadhsc(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Foster et al. (2006)	pubmed:16396496|mint:MINT-5218203	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-921030	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2711|refseq:NP_036883.1|refseq:XP_006246658.1|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007611"(learning or memory)|go:"GO:0007614"(short-term memory)|go:"GO:0007616"(long-term memory)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010021"(amylopectin biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031550"(positive regulation of brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044381"(glucose import in response to insulin stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046323"(glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0098694"(regulation of synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0098793"(presynapse)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002441("Glucose transporter, type 4 (GLUT4)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-189200|ensembl:ENSRNOG00000017226(gene)|ensembl:ENSRNOT00000023256(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)	rgd:69321|refseq:NP_476534.1|ensembl:ENSRNOG00000010697(gene)|ensembl:ENSRNOT00000014658(transcript)|go:"GO:0003857"(3-hydroxyacyl-CoA dehydrogenase activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0006635"(fatty acid beta-oxidation)|go:"GO:0009725"(response to hormone)|go:"GO:0014823"(response to activity)|go:"GO:0032868"(response to insulin)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0046676"(negative regulation of insulin secretion)|go:"GO:0050796"(regulation of insulin secretion)|go:"GO:0070403"(NAD+ binding)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|interpro:IPR006108(3-hydroxyacyl-CoA dehydrogenase, C-terminal)|interpro:IPR006176(3-hydroxyacyl-CoA dehydrogenase, NAD binding)|interpro:IPR006180(3-hydroxyacyl-CoA dehydrogenase, conserved site)|interpro:IPR008927(6-phosphogluconate dehydrogenase, C-terminal-like)|interpro:IPR013328(Dehydrogenase, multihelical)|interpro:IPR022694|interpro:IPR036291|mint:Q9WVK7|reactome:R-RNO-77310|reactome:R-RNO-77346|reactome:R-RNO-77348|reactome:R-RNO-77350|reactome:R-RNO-77352	-	-	-	caution:"The participant EBI-349571(P68370) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919386(Q7TP47) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920972(Q5XIP9) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-916419(P11980) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919578(Q8R491) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920554(Q5U3Z7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920647(Q5U2X8) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920585(Q7TP24) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-779677(P05426) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-915744(P02454) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|agonist:Insulin was shown to increase or decrease GLUT4 protein interactions in specific cases.|comment:"Insulin decreased GLUT4 interactions with the following proteins: Q9ER30 (Sarcosin), P09527 (Rab-7), O88960 (N-ethylmaleimide sensitive), P09456 (PKA I regulatory subunit), P27881 (Hexokinase type II), P07872 (Acyl-coenzyme A oxidase), Q6DGF1 (Isocitrate dehydrogenase), Q9EQX9 (Ubiquitin-conjugating), Q63446 (Polyubiquitin), P24268 (Cathepsin D), Q91XW0 (Heat shock protein 86), Q5FVH0 (unknown), P58405 (Striatin 3), Q62667 (Major vault protein), Q66H50 (unknown), Q09167 (splicing factor), Q9JHU5 (Arfaptin 1)."|comment:"Insulin increased GLUT4 interaction with the following proteins:Q9Z1P2 (R-actinin-1), P45592 (Cofilin), Q9QXQ0 (R-actinin-4), P26473 (ADP-ribosylation factor), P26437 (ADP-ribosylation factor),   Q7TNP1 (Basigin 2), Q6P6R2 (Dihydrolipoamide dehydrogenase),   P04797 (GAPDH), Q63081 (Protein disulfide isomerase), P29457 (47 kDa heat shock protein), Q9R1J8 (Leprecan), O88638 (Putative eps protein),   Q64375 (Synaptonemal complex)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:NDPK - Interactions involving proteins containing InterPro domain IPR001564, Nucleoside diphosphate kinase, core.	taxid:10116(rat-l6)|taxid:10116(Rattus norvegicus)	-	2006/02/15	2021/11/30	rogid:PbFY2lfrty8yw40Jq7ShR7xfuV410116	rogid:dqTvCevVe76aVj0jADypt3XzWa810116	intact-crc:44F3A2176D02515F|rigid:9RVm0UBcqQF4k06RGKO89Bg16Q8	false	myc tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P19357	uniprotkb:Q9WVK3	intact:EBI-915426|uniprotkb:P97900|ensembl:ENSRNOP00000023256	intact:EBI-920213	psi-mi:glut4_rat(display_long)|uniprotkb:Glucose transporter type 4, insulin-responsive(gene name synonym)|uniprotkb:Slc2a4(gene name)|psi-mi:Slc2a4(display_short)|uniprotkb:Glut4(gene name synonym)	psi-mi:pecr_rat(display_long)|uniprotkb:Pecr(gene name)|psi-mi:Pecr(display_short)|uniprotkb:RLF98(gene name synonym)|uniprotkb:Peroxisomal 2,4-dienoyl-CoA reductase(gene name synonym)|uniprotkb:PX-2,4-DCR1(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Foster et al. (2006)	pubmed:16396496|mint:MINT-5218203	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-921030	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2711|refseq:NP_036883.1|refseq:XP_006246658.1|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007611"(learning or memory)|go:"GO:0007614"(short-term memory)|go:"GO:0007616"(long-term memory)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010021"(amylopectin biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031550"(positive regulation of brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044381"(glucose import in response to insulin stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046323"(glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0098694"(regulation of synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0098793"(presynapse)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002441("Glucose transporter, type 4 (GLUT4)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-189200|ensembl:ENSRNOG00000017226(gene)|ensembl:ENSRNOT00000023256(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)	rgd:70925|refseq:NP_579833.1|interpro:IPR002347(Glucose/ribitol dehydrogenase)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005777"(peroxisome)|go:"GO:0005778"(peroxisomal membrane)|go:"GO:0006633"(fatty acid biosynthetic process)|go:"GO:0019166"("trans-2-enoyl-CoA reductase (NADPH) activity")|go:"GO:0033306"(phytol metabolic process)|go:"GO:0043231"(intracellular membrane-bounded organelle)|interpro:IPR036291|reactome:R-RNO-389599|reactome:R-RNO-9033241	-	-	-	caution:"The participant EBI-349571(P68370) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919386(Q7TP47) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920972(Q5XIP9) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-916419(P11980) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919578(Q8R491) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920554(Q5U3Z7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920647(Q5U2X8) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920585(Q7TP24) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-779677(P05426) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-915744(P02454) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|agonist:Insulin was shown to increase or decrease GLUT4 protein interactions in specific cases.|comment:"Insulin decreased GLUT4 interactions with the following proteins: Q9ER30 (Sarcosin), P09527 (Rab-7), O88960 (N-ethylmaleimide sensitive), P09456 (PKA I regulatory subunit), P27881 (Hexokinase type II), P07872 (Acyl-coenzyme A oxidase), Q6DGF1 (Isocitrate dehydrogenase), Q9EQX9 (Ubiquitin-conjugating), Q63446 (Polyubiquitin), P24268 (Cathepsin D), Q91XW0 (Heat shock protein 86), Q5FVH0 (unknown), P58405 (Striatin 3), Q62667 (Major vault protein), Q66H50 (unknown), Q09167 (splicing factor), Q9JHU5 (Arfaptin 1)."|comment:"Insulin increased GLUT4 interaction with the following proteins:Q9Z1P2 (R-actinin-1), P45592 (Cofilin), Q9QXQ0 (R-actinin-4), P26473 (ADP-ribosylation factor), P26437 (ADP-ribosylation factor),   Q7TNP1 (Basigin 2), Q6P6R2 (Dihydrolipoamide dehydrogenase),   P04797 (GAPDH), Q63081 (Protein disulfide isomerase), P29457 (47 kDa heat shock protein), Q9R1J8 (Leprecan), O88638 (Putative eps protein),   Q64375 (Synaptonemal complex)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:NDPK - Interactions involving proteins containing InterPro domain IPR001564, Nucleoside diphosphate kinase, core.	taxid:10116(rat-l6)|taxid:10116(Rattus norvegicus)	-	2006/02/15	2021/11/30	rogid:PbFY2lfrty8yw40Jq7ShR7xfuV410116	rogid:LR/HTsmk7CIokJJxWuOFzF7pf4w10116	intact-crc:44F3A2176D02515F|rigid:9RVm0UBcqQF4k06RGKO89Bg16Q8	false	myc tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P19357	uniprotkb:Q9WVC0	intact:EBI-915426|uniprotkb:P97900|ensembl:ENSRNOP00000023256	intact:EBI-920205	psi-mi:glut4_rat(display_long)|uniprotkb:Glucose transporter type 4, insulin-responsive(gene name synonym)|uniprotkb:Slc2a4(gene name)|psi-mi:Slc2a4(display_short)|uniprotkb:Glut4(gene name synonym)	psi-mi:sept7_rat(display_long)|uniprotkb:Septin7(gene name)|psi-mi:Septin7(display_short)|uniprotkb:CDC10 protein homolog(gene name synonym)|uniprotkb:Cdc10(gene name synonym)|uniprotkb:Sept7(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Foster et al. (2006)	pubmed:16396496|mint:MINT-5218203	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-921030	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2711|refseq:NP_036883.1|refseq:XP_006246658.1|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007611"(learning or memory)|go:"GO:0007614"(short-term memory)|go:"GO:0007616"(long-term memory)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010021"(amylopectin biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031550"(positive regulation of brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044381"(glucose import in response to insulin stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046323"(glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0098694"(regulation of synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0098793"(presynapse)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002441("Glucose transporter, type 4 (GLUT4)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-189200|ensembl:ENSRNOG00000017226(gene)|ensembl:ENSRNOT00000023256(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)	rgd:620469|refseq:NP_072138.2|interpro:IPR016491(Septin)|interpro:IPR008115(Septin 7)|interpro:IPR030379|go:"GO:0000281"(mitotic cytokinesis)|go:"GO:0000776"(kinetochore)|go:"GO:0001725"(stress fiber)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005819"(spindle)|go:"GO:0005930"(axoneme)|go:"GO:0005938"(cell cortex)|go:"GO:0005940"(septin ring)|go:"GO:0007283"(spermatogenesis)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0016476"(regulation of embryonic cell shape)|go:"GO:0030496"(midbody)|go:"GO:0030865"(cortical cytoskeleton organization)|go:"GO:0031105"(septin complex)|go:"GO:0031270"(pseudopodium retraction)|go:"GO:0032153"(cell division site)|go:"GO:0032154"(cleavage furrow)|go:"GO:0032156"(septin cytoskeleton)|go:"GO:0032160"(septin filament array)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034613"(cellular protein localization)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043679"(axon terminus)|go:"GO:0044297"(cell body)|go:"GO:0045202"(synapse)|go:"GO:0048668"(collateral sprouting)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0060271"(cilium assembly)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0061640"(cytoskeleton-dependent cytokinesis)|go:"GO:0097227"(sperm annulus)|go:"GO:0097730"(non-motile cilium)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099173"(postsynapse organization)|go:"GO:1902857"(positive regulation of non-motile cilium assembly)|reactome:R-RNO-5687128|mint:Q9WVC0|interpro:IPR027417	-	-	-	caution:"The participant EBI-349571(P68370) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919386(Q7TP47) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920972(Q5XIP9) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-916419(P11980) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919578(Q8R491) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920554(Q5U3Z7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920647(Q5U2X8) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920585(Q7TP24) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-779677(P05426) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-915744(P02454) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|agonist:Insulin was shown to increase or decrease GLUT4 protein interactions in specific cases.|comment:"Insulin decreased GLUT4 interactions with the following proteins: Q9ER30 (Sarcosin), P09527 (Rab-7), O88960 (N-ethylmaleimide sensitive), P09456 (PKA I regulatory subunit), P27881 (Hexokinase type II), P07872 (Acyl-coenzyme A oxidase), Q6DGF1 (Isocitrate dehydrogenase), Q9EQX9 (Ubiquitin-conjugating), Q63446 (Polyubiquitin), P24268 (Cathepsin D), Q91XW0 (Heat shock protein 86), Q5FVH0 (unknown), P58405 (Striatin 3), Q62667 (Major vault protein), Q66H50 (unknown), Q09167 (splicing factor), Q9JHU5 (Arfaptin 1)."|comment:"Insulin increased GLUT4 interaction with the following proteins:Q9Z1P2 (R-actinin-1), P45592 (Cofilin), Q9QXQ0 (R-actinin-4), P26473 (ADP-ribosylation factor), P26437 (ADP-ribosylation factor),   Q7TNP1 (Basigin 2), Q6P6R2 (Dihydrolipoamide dehydrogenase),   P04797 (GAPDH), Q63081 (Protein disulfide isomerase), P29457 (47 kDa heat shock protein), Q9R1J8 (Leprecan), O88638 (Putative eps protein),   Q64375 (Synaptonemal complex)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:NDPK - Interactions involving proteins containing InterPro domain IPR001564, Nucleoside diphosphate kinase, core.	taxid:10116(rat-l6)|taxid:10116(Rattus norvegicus)	-	2006/02/15	2021/11/30	rogid:PbFY2lfrty8yw40Jq7ShR7xfuV410116	rogid:9EZtQeaSe4YkMHjuuPUXRvOTGGE10116	intact-crc:44F3A2176D02515F|rigid:9RVm0UBcqQF4k06RGKO89Bg16Q8	false	myc tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P19357	uniprotkb:Q9WVB1	intact:EBI-915426|uniprotkb:P97900|ensembl:ENSRNOP00000023256	intact:EBI-920195|ensembl:ENSRNOP00000073670	psi-mi:glut4_rat(display_long)|uniprotkb:Glucose transporter type 4, insulin-responsive(gene name synonym)|uniprotkb:Slc2a4(gene name)|psi-mi:Slc2a4(display_short)|uniprotkb:Glut4(gene name synonym)	psi-mi:rab6a_rat(display_long)|uniprotkb:Rab6a(gene name)|psi-mi:Rab6a(display_short)|uniprotkb:Rab6(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Foster et al. (2006)	pubmed:16396496|mint:MINT-5218203	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-921030	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2711|refseq:NP_036883.1|refseq:XP_006246658.1|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007611"(learning or memory)|go:"GO:0007614"(short-term memory)|go:"GO:0007616"(long-term memory)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010021"(amylopectin biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031550"(positive regulation of brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044381"(glucose import in response to insulin stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046323"(glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0098694"(regulation of synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0098793"(presynapse)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002441("Glucose transporter, type 4 (GLUT4)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-189200|ensembl:ENSRNOG00000017226(gene)|ensembl:ENSRNOT00000023256(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)	rgd:619737|refseq:XP_006229856.1|go:"GO:0070381"(endosome to plasma membrane transport vesicle)|go:"GO:0098793"(presynapse)|ensembl:ENSRNOG00000018176(gene)|ensembl:ENSRNOT00000087534(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001671"(ATPase activator activity)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006890"(retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum)|go:"GO:0006891"(intra-Golgi vesicle-mediated transport)|go:"GO:0012505"(endomembrane system)|go:"GO:0016020"(membrane)|go:"GO:0018125"(peptidyl-cysteine methylation)|go:"GO:0019882"(antigen processing and presentation)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031489"(myosin V binding)|go:"GO:0032482"(Rab protein signal transduction)|go:"GO:0034067"(protein localization to Golgi apparatus)|go:"GO:0034498"(early endosome to Golgi transport)|go:"GO:0042147"(retrograde transport, endosome to Golgi)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0051117"(ATPase binding)|interpro:IPR001806(Ras GTPase)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR027417|mint:Q9WVB1|reactome:R-RNO-6798695|reactome:R-RNO-6811436|reactome:R-RNO-6811440|reactome:R-RNO-8854214|reactome:R-RNO-8873719|reactome:R-RNO-8876198	-	-	-	caution:"The participant EBI-349571(P68370) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919386(Q7TP47) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920972(Q5XIP9) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-916419(P11980) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919578(Q8R491) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920554(Q5U3Z7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920647(Q5U2X8) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920585(Q7TP24) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-779677(P05426) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-915744(P02454) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|agonist:Insulin was shown to increase or decrease GLUT4 protein interactions in specific cases.|comment:"Insulin decreased GLUT4 interactions with the following proteins: Q9ER30 (Sarcosin), P09527 (Rab-7), O88960 (N-ethylmaleimide sensitive), P09456 (PKA I regulatory subunit), P27881 (Hexokinase type II), P07872 (Acyl-coenzyme A oxidase), Q6DGF1 (Isocitrate dehydrogenase), Q9EQX9 (Ubiquitin-conjugating), Q63446 (Polyubiquitin), P24268 (Cathepsin D), Q91XW0 (Heat shock protein 86), Q5FVH0 (unknown), P58405 (Striatin 3), Q62667 (Major vault protein), Q66H50 (unknown), Q09167 (splicing factor), Q9JHU5 (Arfaptin 1)."|comment:"Insulin increased GLUT4 interaction with the following proteins:Q9Z1P2 (R-actinin-1), P45592 (Cofilin), Q9QXQ0 (R-actinin-4), P26473 (ADP-ribosylation factor), P26437 (ADP-ribosylation factor),   Q7TNP1 (Basigin 2), Q6P6R2 (Dihydrolipoamide dehydrogenase),   P04797 (GAPDH), Q63081 (Protein disulfide isomerase), P29457 (47 kDa heat shock protein), Q9R1J8 (Leprecan), O88638 (Putative eps protein),   Q64375 (Synaptonemal complex)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:NDPK - Interactions involving proteins containing InterPro domain IPR001564, Nucleoside diphosphate kinase, core.	taxid:10116(rat-l6)|taxid:10116(Rattus norvegicus)	-	2006/02/15	2021/11/30	rogid:PbFY2lfrty8yw40Jq7ShR7xfuV410116	rogid:dvs8ZexwDDVZ3QFifBZ+id2D0+k10116	intact-crc:44F3A2176D02515F|rigid:9RVm0UBcqQF4k06RGKO89Bg16Q8	false	myc tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P19357	uniprotkb:Q2PQA9	intact:EBI-915426|uniprotkb:P97900|ensembl:ENSRNOP00000023256	intact:EBI-920191|uniprotkb:Q9WV65|ensembl:ENSRNOP00000023860	psi-mi:glut4_rat(display_long)|uniprotkb:Glucose transporter type 4, insulin-responsive(gene name synonym)|uniprotkb:Slc2a4(gene name)|psi-mi:Slc2a4(display_short)|uniprotkb:Glut4(gene name synonym)	psi-mi:kinh_rat(display_long)|uniprotkb:Kif5b(gene name)|psi-mi:Kif5b(display_short)|uniprotkb:Ubiquitous kinesin heavy chain(gene name synonym)|uniprotkb:Conventional kinesin heavy chain(gene name synonym)|uniprotkb:Khc(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Foster et al. (2006)	pubmed:16396496|mint:MINT-5218203	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-921030	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2711|refseq:NP_036883.1|refseq:XP_006246658.1|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007611"(learning or memory)|go:"GO:0007614"(short-term memory)|go:"GO:0007616"(long-term memory)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010021"(amylopectin biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031550"(positive regulation of brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044381"(glucose import in response to insulin stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046323"(glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0098694"(regulation of synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0098793"(presynapse)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002441("Glucose transporter, type 4 (GLUT4)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-189200|ensembl:ENSRNOG00000017226(gene)|ensembl:ENSRNOT00000023256(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)	rgd:621559|refseq:NP_476550.1|refseq:XP_006254067.1|ensembl:ENSRNOG00000017466(gene)|ensembl:ENSRNOT00000023861(transcript)|go:"GO:0003777"(microtubule motor activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005871"(kinesin complex)|go:"GO:0005874"(microtubule)|go:"GO:0007018"(microtubule-based movement)|go:"GO:0007028"(cytoplasm organization)|go:"GO:0007411"(axon guidance)|go:"GO:0007420"(brain development)|go:"GO:0008017"(microtubule binding)|go:"GO:0008432"(JUN kinase binding)|go:"GO:0008574"(plus-end-directed microtubule motor activity)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0021766"(hippocampus development)|go:"GO:0030139"(endocytic vesicle)|go:"GO:0030705"(cytoskeleton-dependent intracellular transport)|go:"GO:0031340"(positive regulation of vesicle fusion)|go:"GO:0031982"(vesicle)|go:"GO:0032230"(positive regulation of synaptic transmission, GABAergic)|go:"GO:0032418"(lysosome localization)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0034451"(centriolar satellite)|go:"GO:0035253"(ciliary rootlet)|go:"GO:0035617"(stress granule disassembly)|go:"GO:0035774"(positive regulation of insulin secretion involved in cellular response to glucose stimulus)|go:"GO:0042267"(natural killer cell mediated cytotoxicity)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043227"(membrane-bounded organelle)|go:"GO:0043268"(positive regulation of potassium ion transport)|go:"GO:0044295"(axonal growth cone)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0047496"(vesicle transport along microtubule)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048489"(synaptic vesicle transport)|go:"GO:0051642"(centrosome localization)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0072383"(plus-end-directed vesicle transport along microtubule)|go:"GO:0090316"(positive regulation of intracellular protein transport)|go:"GO:0098971"(anterograde dendritic transport of neurotransmitter receptor complex)|go:"GO:0099609"(microtubule lateral binding)|go:"GO:0099641"(anterograde axonal protein transport)|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|go:"GO:1904115"(axon cytoplasm)|go:"GO:1905152"(positive regulation of voltage-gated sodium channel activity)|go:"GO:1990049"(retrograde neuronal dense core vesicle transport)|interpro:IPR001752(Kinesin, motor region)|interpro:IPR019821|interpro:IPR027417|interpro:IPR027640|interpro:IPR036961|mint:Q2PQA9|rcsb pdb:4ATX|reactome:R-RNO-2132295|reactome:R-RNO-5625970|reactome:R-RNO-6811434|reactome:R-RNO-983189|dip:DIP-37054N	-	-	-	caution:"The participant EBI-349571(P68370) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919386(Q7TP47) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920972(Q5XIP9) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-916419(P11980) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919578(Q8R491) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920554(Q5U3Z7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920647(Q5U2X8) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920585(Q7TP24) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-779677(P05426) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-915744(P02454) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|agonist:Insulin was shown to increase or decrease GLUT4 protein interactions in specific cases.|comment:"Insulin decreased GLUT4 interactions with the following proteins: Q9ER30 (Sarcosin), P09527 (Rab-7), O88960 (N-ethylmaleimide sensitive), P09456 (PKA I regulatory subunit), P27881 (Hexokinase type II), P07872 (Acyl-coenzyme A oxidase), Q6DGF1 (Isocitrate dehydrogenase), Q9EQX9 (Ubiquitin-conjugating), Q63446 (Polyubiquitin), P24268 (Cathepsin D), Q91XW0 (Heat shock protein 86), Q5FVH0 (unknown), P58405 (Striatin 3), Q62667 (Major vault protein), Q66H50 (unknown), Q09167 (splicing factor), Q9JHU5 (Arfaptin 1)."|comment:"Insulin increased GLUT4 interaction with the following proteins:Q9Z1P2 (R-actinin-1), P45592 (Cofilin), Q9QXQ0 (R-actinin-4), P26473 (ADP-ribosylation factor), P26437 (ADP-ribosylation factor),   Q7TNP1 (Basigin 2), Q6P6R2 (Dihydrolipoamide dehydrogenase),   P04797 (GAPDH), Q63081 (Protein disulfide isomerase), P29457 (47 kDa heat shock protein), Q9R1J8 (Leprecan), O88638 (Putative eps protein),   Q64375 (Synaptonemal complex)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:NDPK - Interactions involving proteins containing InterPro domain IPR001564, Nucleoside diphosphate kinase, core.	taxid:10116(rat-l6)|taxid:10116(Rattus norvegicus)	-	2006/02/15	2021/11/30	rogid:PbFY2lfrty8yw40Jq7ShR7xfuV410116	rogid:OjHE/OLj2diwiW5HI0HFHEDkbjY10116	intact-crc:44F3A2176D02515F|rigid:9RVm0UBcqQF4k06RGKO89Bg16Q8	false	myc tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P19357	uniprotkb:Q9WU82	intact:EBI-915426|uniprotkb:P97900|ensembl:ENSRNOP00000023256	intact:EBI-920177	psi-mi:glut4_rat(display_long)|uniprotkb:Glucose transporter type 4, insulin-responsive(gene name synonym)|uniprotkb:Slc2a4(gene name)|psi-mi:Slc2a4(display_short)|uniprotkb:Glut4(gene name synonym)	psi-mi:ctnb1_rat(display_long)|uniprotkb:Ctnnb1(gene name)|psi-mi:Ctnnb1(display_short)|uniprotkb:Catnb(gene name synonym)|uniprotkb:Beta-catenin(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Foster et al. (2006)	pubmed:16396496|mint:MINT-5218203	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-921030	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2711|refseq:NP_036883.1|refseq:XP_006246658.1|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007611"(learning or memory)|go:"GO:0007614"(short-term memory)|go:"GO:0007616"(long-term memory)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010021"(amylopectin biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031550"(positive regulation of brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044381"(glucose import in response to insulin stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046323"(glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0098694"(regulation of synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0098793"(presynapse)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002441("Glucose transporter, type 4 (GLUT4)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-189200|ensembl:ENSRNOG00000017226(gene)|ensembl:ENSRNOT00000023256(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)	rgd:70487|refseq:NP_445809.2|refseq:XP_008764913.1|refseq:XP_017451425.1|refseq:XP_017451426.1|refseq:XP_017451428.1|refseq:XP_017451429.1|mint:Q9WU82|dip:DIP-37053N|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0000578"(embryonic axis specification)|go:"GO:0000791"(euchromatin)|go:"GO:0000904"(cell morphogenesis involved in differentiation)|go:"GO:0000922"(spindle pole)|go:"GO:0001221"(transcription coregulator binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0001569"(branching involved in blood vessel morphogenesis)|go:"GO:0001570"(vasculogenesis)|go:"GO:0001658"(branching involved in ureteric bud morphogenesis)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001702"(gastrulation with mouth forming second)|go:"GO:0001706"(endoderm formation)|go:"GO:0001708"(cell fate specification)|go:"GO:0001709"(cell fate determination)|go:"GO:0001711"(endodermal cell fate commitment)|go:"GO:0001764"(neuron migration)|go:"GO:0001822"(kidney development)|go:"GO:0001840"(neural plate development)|go:"GO:0001889"(liver development)|go:"GO:0001894"(tissue homeostasis)|go:"GO:0001944"(vasculature development)|go:"GO:0002052"(positive regulation of neuroblast proliferation)|go:"GO:0002053"(positive regulation of mesenchymal cell proliferation)|go:"GO:0002089"(lens morphogenesis in camera-type eye)|go:"GO:0003266"(regulation of secondary heart field cardioblast proliferation)|go:"GO:0003338"(metanephros morphogenesis)|go:"GO:0003340"(negative regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis)|go:"GO:0003682"(chromatin binding)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005912"(adherens junction)|go:"GO:0005916"(fascia adherens)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0005938"(cell cortex)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007155"(cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007398"(ectoderm development)|go:"GO:0007403"(glial cell fate determination)|go:"GO:0007494"(midgut development)|go:"GO:0007507"(heart development)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009725"(response to hormone)|go:"GO:0009948"(anterior/posterior axis specification)|go:"GO:0009950"(dorsal/ventral axis specification)|go:"GO:0009953"(dorsal/ventral pattern formation)|go:"GO:0009954"(proximal/distal pattern formation)|go:"GO:0009987"(cellular process)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010718"(positive regulation of epithelial to mesenchymal transition)|go:"GO:0010909"(positive regulation of heparan sulfate proteoglycan biosynthetic process)|go:"GO:0014010"(Schwann cell proliferation)|go:"GO:0014070"(response to organic cyclic compound)|go:"GO:0014704"(intercalated disc)|go:"GO:0014823"(response to activity)|go:"GO:0016020"(membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016327"(apicolateral plasma membrane)|go:"GO:0016328"(lateral plasma membrane)|go:"GO:0016331"(morphogenesis of embryonic epithelium)|go:"GO:0016342"(catenin complex)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0016600"(flotillin complex)|go:"GO:0016922"(nuclear receptor binding)|go:"GO:0019899"(enzyme binding)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0021819"(layer formation in cerebral cortex)|go:"GO:0022009"(central nervous system vasculogenesis)|go:"GO:0022405"(hair cycle process)|go:"GO:0030018"(Z disc)|go:"GO:0030027"(lamellipodium)|go:"GO:0030054"(cell junction)|go:"GO:0030097"(hemopoiesis)|go:"GO:0030154"(cell differentiation)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030217"(T cell differentiation)|go:"GO:0030316"(osteoclast differentiation)|go:"GO:0030324"(lung development)|go:"GO:0030331"(estrogen receptor binding)|go:"GO:0030539"(male genitalia development)|go:"GO:0030856"(regulation of epithelial cell differentiation)|go:"GO:0030858"(positive regulation of epithelial cell differentiation)|go:"GO:0030877"(beta-catenin destruction complex)|go:"GO:0030900"(forebrain development)|go:"GO:0030901"(midbrain development)|go:"GO:0030902"(hindbrain development)|go:"GO:0030997"(regulation of centriole-centriole cohesion)|go:"GO:0031016"(pancreas development)|go:"GO:0031069"(hair follicle morphogenesis)|go:"GO:0031253"(cell projection membrane)|go:"GO:0031528"(microvillus membrane)|go:"GO:0031641"(regulation of myelination)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032212"(positive regulation of telomere maintenance via telomerase)|go:"GO:0032331"(negative regulation of chondrocyte differentiation)|go:"GO:0032355"(response to estradiol)|go:"GO:0032968"(positive regulation of transcription elongation from RNA polymerase II promoter)|go:"GO:0032991"(protein-containing complex)|go:"GO:0032993"(protein-DNA complex)|go:"GO:0033077"(T cell differentiation in thymus)|go:"GO:0033234"(negative regulation of protein sumoylation)|go:"GO:0034097"(response to cytokine)|go:"GO:0034332"(adherens junction organization)|go:"GO:0034333"(adherens junction assembly)|go:"GO:0034394"(protein localization to cell surface)|go:"GO:0034613"(cellular protein localization)|go:"GO:0034750"(Scrib-APC-beta-catenin complex)|go:"GO:0035050"(embryonic heart tube development)|go:"GO:0035112"(genitalia morphogenesis)|go:"GO:0035115"(embryonic forelimb morphogenesis)|go:"GO:0035116"(embryonic hindlimb morphogenesis)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0036023"(embryonic skeletal limb joint morphogenesis)|go:"GO:0036520"(astrocyte-dopaminergic neuron signaling)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042129"(regulation of T cell proliferation)|go:"GO:0042475"(odontogenesis of dentin-containing tooth)|go:"GO:0042493"|go:"GO:0042733"(embryonic digit morphogenesis)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0043198"(dendritic shaft)|go:"GO:0043296"(apical junction complex)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0043588"(skin development)|go:"GO:0043627"(response to estrogen)|go:"GO:0044093"(positive regulation of molecular function)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044334"(canonical Wnt signaling pathway involved in positive regulation of epithelial to mesenchymal transition)|go:"GO:0044338"(canonical Wnt signaling pathway involved in mesenchymal stem cell differentiation)|go:"GO:0044344"(cellular response to fibroblast growth factor stimulus)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045177"(apical part of cell)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045294"(alpha-catenin binding)|go:"GO:0045296"(cadherin binding)|go:"GO:0045445"(myoblast differentiation)|go:"GO:0045453"(bone resorption)|go:"GO:0045595"(regulation of cell differentiation)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0045603"(positive regulation of endothelial cell differentiation)|go:"GO:0045667"(regulation of osteoblast differentiation)|go:"GO:0045669"(positive regulation of osteoblast differentiation)|go:"GO:0045670"(regulation of osteoclast differentiation)|go:"GO:0045671"(negative regulation of osteoclast differentiation)|go:"GO:0045743"(positive regulation of fibroblast growth factor receptor signaling pathway)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0045976"(negative regulation of mitotic cell cycle, embryonic)|go:"GO:0046332"(SMAD binding)|go:"GO:0046686"(response to cadmium ion)|go:"GO:0046849"(bone remodeling)|go:"GO:0048469"(cell maturation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048489"(synaptic vesicle transport)|go:"GO:0048513"(animal organ development)|go:"GO:0048538"(thymus development)|go:"GO:0048568"(embryonic organ development)|go:"GO:0048599"(oocyte development)|go:"GO:0048617"(embryonic foregut morphogenesis)|go:"GO:0048643"(positive regulation of skeletal muscle tissue development)|go:"GO:0048660"(regulation of smooth muscle cell proliferation)|go:"GO:0048715"(negative regulation of oligodendrocyte differentiation)|go:"GO:0050768"(negative regulation of neurogenesis)|go:"GO:0050808"(synapse organization)|go:"GO:0050998"(nitric-oxide synthase binding)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051145"(smooth muscle cell differentiation)|go:"GO:0051571"(positive regulation of histone H3-K4 methylation)|go:"GO:0051884"(regulation of timing of anagen)|go:"GO:0051973"(positive regulation of telomerase activity)|go:"GO:0060066"(oviduct development)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0060173"(limb development)|go:"GO:0060439"(trachea morphogenesis)|go:"GO:0060440"(trachea formation)|go:"GO:0060441"(epithelial tube branching involved in lung morphogenesis)|go:"GO:0060479"(lung cell differentiation)|go:"GO:0060484"(lung-associated mesenchyme development)|go:"GO:0060492"(lung induction)|go:"GO:0060742"(epithelial cell differentiation involved in prostate gland development)|go:"GO:0060769"(positive regulation of epithelial cell proliferation involved in prostate gland development)|go:"GO:0060789"(hair follicle placode formation)|go:"GO:0060916"(mesenchymal cell proliferation involved in lung development)|go:"GO:0061047"(positive regulation of branching involved in lung morphogenesis)|go:"GO:0061154"(endothelial tube morphogenesis)|go:"GO:0061198"(fungiform papilla formation)|go:"GO:0061324"(canonical Wnt signaling pathway involved in positive regulation of cardiac outflow tract cell proliferation)|go:"GO:0061549"(sympathetic ganglion development)|go:"GO:0061550"(cranial ganglion development)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070369"(beta-catenin-TCF7L2 complex)|go:"GO:0070411"(I-SMAD binding)|go:"GO:0070602"(regulation of centromeric sister chromatid cohesion)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071285"(cellular response to lithium ion)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0071681"(cellular response to indole-3-methanol)|go:"GO:0071944"(cell periphery)|go:"GO:0072033"(renal vesicle formation)|go:"GO:0072053"(renal inner medulla development)|go:"GO:0072054"(renal outer medulla development)|go:"GO:0072079"(nephron tubule formation)|go:"GO:0072182"(regulation of nephron tubule epithelial cell differentiation)|go:"GO:0090279"(regulation of calcium ion import)|go:"GO:0097091"(synaptic vesicle clustering)|go:"GO:0097718"(disordered domain specific binding)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098831"(presynaptic active zone cytoplasmic component)|go:"GO:0099092"(postsynaptic density, intracellular component)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1903204"(negative regulation of oxidative stress-induced neuron death)|go:"GO:1904796"(regulation of core promoter binding)|go:"GO:1904798"(positive regulation of core promoter binding)|go:"GO:1904888"(cranial skeletal system development)|go:"GO:1904948"(midbrain dopaminergic neuron differentiation)|go:"GO:1990138"(neuron projection extension)|go:"GO:1990226"(histone methyltransferase binding)|go:"GO:1990314"(cellular response to insulin-like growth factor stimulus)|go:"GO:1990403"(embryonic brain development)|go:"GO:1990791"(dorsal root ganglion development)|go:"GO:1990907"(beta-catenin-TCF complex)|go:"GO:1990909"(Wnt signalosome)|go:"GO:2000008"(regulation of protein localization to cell surface)|go:"GO:2000017"(positive regulation of determination of dorsal identity)|go:"GO:2000179"(positive regulation of neural precursor cell proliferation)|go:"GO:2001234"(negative regulation of apoptotic signaling pathway)|interpro:IPR000225(Armadillo)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR013284(Beta-catenin)|interpro:IPR016024(Armadillo-type fold)|reactome:R-RNO-195253|reactome:R-RNO-196299|reactome:R-RNO-201681|reactome:R-RNO-201722|reactome:R-RNO-3134973|reactome:R-RNO-351906|reactome:R-RNO-3769402|reactome:R-RNO-4086398|reactome:R-RNO-418990|reactome:R-RNO-4641262|reactome:R-RNO-5218920|reactome:R-RNO-525793|reactome:R-RNO-5626467|reactome:R-RNO-8951430	-	-	-	caution:"The participant EBI-349571(P68370) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919386(Q7TP47) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920972(Q5XIP9) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-916419(P11980) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919578(Q8R491) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920554(Q5U3Z7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920647(Q5U2X8) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920585(Q7TP24) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-779677(P05426) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-915744(P02454) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|agonist:Insulin was shown to increase or decrease GLUT4 protein interactions in specific cases.|comment:"Insulin decreased GLUT4 interactions with the following proteins: Q9ER30 (Sarcosin), P09527 (Rab-7), O88960 (N-ethylmaleimide sensitive), P09456 (PKA I regulatory subunit), P27881 (Hexokinase type II), P07872 (Acyl-coenzyme A oxidase), Q6DGF1 (Isocitrate dehydrogenase), Q9EQX9 (Ubiquitin-conjugating), Q63446 (Polyubiquitin), P24268 (Cathepsin D), Q91XW0 (Heat shock protein 86), Q5FVH0 (unknown), P58405 (Striatin 3), Q62667 (Major vault protein), Q66H50 (unknown), Q09167 (splicing factor), Q9JHU5 (Arfaptin 1)."|comment:"Insulin increased GLUT4 interaction with the following proteins:Q9Z1P2 (R-actinin-1), P45592 (Cofilin), Q9QXQ0 (R-actinin-4), P26473 (ADP-ribosylation factor), P26437 (ADP-ribosylation factor),   Q7TNP1 (Basigin 2), Q6P6R2 (Dihydrolipoamide dehydrogenase),   P04797 (GAPDH), Q63081 (Protein disulfide isomerase), P29457 (47 kDa heat shock protein), Q9R1J8 (Leprecan), O88638 (Putative eps protein),   Q64375 (Synaptonemal complex)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:NDPK - Interactions involving proteins containing InterPro domain IPR001564, Nucleoside diphosphate kinase, core.	taxid:10116(rat-l6)|taxid:10116(Rattus norvegicus)	-	2006/02/15	2021/11/30	rogid:PbFY2lfrty8yw40Jq7ShR7xfuV410116	rogid:EQ9j/nvYumuF5gT++5hCWaL8cyw10116	intact-crc:44F3A2176D02515F|rigid:9RVm0UBcqQF4k06RGKO89Bg16Q8	false	myc tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P19357	uniprotkb:Q9WVR3	intact:EBI-915426|uniprotkb:P97900|ensembl:ENSRNOP00000023256	intact:EBI-920167|uniprotkb:Q9R1V2	psi-mi:glut4_rat(display_long)|uniprotkb:Glucose transporter type 4, insulin-responsive(gene name synonym)|uniprotkb:Slc2a4(gene name)|psi-mi:Slc2a4(display_short)|uniprotkb:Glut4(gene name synonym)	psi-mi:ship2_rat(display_long)|uniprotkb:Inppl1(gene name)|psi-mi:Inppl1(display_short)|uniprotkb:Ship2(gene name synonym)|uniprotkb:Inositol polyphosphate phosphatase-like protein 1(gene name synonym)|uniprotkb:SH2 domain-containing inositol 5'-phosphatase 2(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Foster et al. (2006)	pubmed:16396496|mint:MINT-5218203	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-921030	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2711|refseq:NP_036883.1|refseq:XP_006246658.1|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007611"(learning or memory)|go:"GO:0007614"(short-term memory)|go:"GO:0007616"(long-term memory)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010021"(amylopectin biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031550"(positive regulation of brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044381"(glucose import in response to insulin stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046323"(glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0098694"(regulation of synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0098793"(presynapse)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002441("Glucose transporter, type 4 (GLUT4)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-189200|ensembl:ENSRNOG00000017226(gene)|ensembl:ENSRNOT00000023256(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)	rgd:68396|refseq:NP_075233.1|interpro:IPR005135(Endonuclease/exonuclease/phosphatase)|interpro:IPR000300(Inositol polyphosphate related phosphatase)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR000980(SH2 motif)|refseq:NP_001257772.1|interpro:IPR036691|interpro:IPR036860|reactome:R-RNO-1660499|reactome:R-RNO-1855204|reactome:R-RNO-912526|go:"GO:0042169"(SH2 domain binding)|go:"GO:0042493"|go:"GO:0043407"(negative regulation of MAP kinase activity)|go:"GO:0043569"(negative regulation of insulin-like growth factor receptor signaling pathway)|go:"GO:0044255"(cellular lipid metabolic process)|go:"GO:0046627"(negative regulation of insulin receptor signaling pathway)|go:"GO:0046856"(phosphatidylinositol dephosphorylation)|go:"GO:0097178"(ruffle assembly)|go:"GO:0001958"(endochondral ossification)|go:"GO:0002376"(immune system process)|go:"GO:0003779"(actin binding)|go:"GO:0004445"(inositol-polyphosphate 5-phosphatase activity)|go:"GO:0005547"(phosphatidylinositol-3,4,5-trisphosphate binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0006006"(glucose metabolic process)|go:"GO:0006661"(phosphatidylinositol biosynthetic process)|go:"GO:0006897"(endocytosis)|go:"GO:0007015"(actin filament organization)|go:"GO:0007155"(cell adhesion)|go:"GO:0007420"(brain development)|go:"GO:0008156"(negative regulation of DNA replication)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009791"(post-embryonic development)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010642"(negative regulation of platelet-derived growth factor receptor signaling pathway)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0016607"(nuclear speck)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0030027"(lamellipodium)|go:"GO:0030175"(filopodium)|go:"GO:0032868"(response to insulin)|go:"GO:0032957"(inositol trisphosphate metabolic process)|go:"GO:0034485"(phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity)	-	-	-	caution:"The participant EBI-349571(P68370) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919386(Q7TP47) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920972(Q5XIP9) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-916419(P11980) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919578(Q8R491) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920554(Q5U3Z7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920647(Q5U2X8) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920585(Q7TP24) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-779677(P05426) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-915744(P02454) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|agonist:Insulin was shown to increase or decrease GLUT4 protein interactions in specific cases.|comment:"Insulin decreased GLUT4 interactions with the following proteins: Q9ER30 (Sarcosin), P09527 (Rab-7), O88960 (N-ethylmaleimide sensitive), P09456 (PKA I regulatory subunit), P27881 (Hexokinase type II), P07872 (Acyl-coenzyme A oxidase), Q6DGF1 (Isocitrate dehydrogenase), Q9EQX9 (Ubiquitin-conjugating), Q63446 (Polyubiquitin), P24268 (Cathepsin D), Q91XW0 (Heat shock protein 86), Q5FVH0 (unknown), P58405 (Striatin 3), Q62667 (Major vault protein), Q66H50 (unknown), Q09167 (splicing factor), Q9JHU5 (Arfaptin 1)."|comment:"Insulin increased GLUT4 interaction with the following proteins:Q9Z1P2 (R-actinin-1), P45592 (Cofilin), Q9QXQ0 (R-actinin-4), P26473 (ADP-ribosylation factor), P26437 (ADP-ribosylation factor),   Q7TNP1 (Basigin 2), Q6P6R2 (Dihydrolipoamide dehydrogenase),   P04797 (GAPDH), Q63081 (Protein disulfide isomerase), P29457 (47 kDa heat shock protein), Q9R1J8 (Leprecan), O88638 (Putative eps protein),   Q64375 (Synaptonemal complex)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:NDPK - Interactions involving proteins containing InterPro domain IPR001564, Nucleoside diphosphate kinase, core.	taxid:10116(rat-l6)|taxid:10116(Rattus norvegicus)	-	2006/02/15	2021/11/30	rogid:PbFY2lfrty8yw40Jq7ShR7xfuV410116	rogid:DZ35e/tVQU+hm96I66cBlTg1aJs10116	intact-crc:44F3A2176D02515F|rigid:9RVm0UBcqQF4k06RGKO89Bg16Q8	false	myc tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P19357	uniprotkb:Q9R1J8	intact:EBI-915426|uniprotkb:P97900|ensembl:ENSRNOP00000023256	intact:EBI-920149	psi-mi:glut4_rat(display_long)|uniprotkb:Glucose transporter type 4, insulin-responsive(gene name synonym)|uniprotkb:Slc2a4(gene name)|psi-mi:Slc2a4(display_short)|uniprotkb:Glut4(gene name synonym)	psi-mi:p3h1_rat(display_long)|uniprotkb:P3h1(gene name)|psi-mi:P3h1(display_short)|uniprotkb:Lepre1(gene name synonym)|uniprotkb:Leucine- and proline-enriched proteoglycan 1(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Foster et al. (2006)	pubmed:16396496|mint:MINT-5218203	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-921030	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2711|refseq:NP_036883.1|refseq:XP_006246658.1|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007611"(learning or memory)|go:"GO:0007614"(short-term memory)|go:"GO:0007616"(long-term memory)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010021"(amylopectin biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031550"(positive regulation of brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044381"(glucose import in response to insulin stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046323"(glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0098694"(regulation of synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0098793"(presynapse)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002441("Glucose transporter, type 4 (GLUT4)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-189200|ensembl:ENSRNOG00000017226(gene)|ensembl:ENSRNOT00000023256(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)	rgd:628823|refseq:NP_446119.1|interpro:IPR005123("2OG-Fe(II) oxygenase")|interpro:IPR006620(Prolyl 4-hydroxylase, alpha subunit)|interpro:IPR039575|interpro:IPR039837|reactome:R-RNO-1650814|go:"GO:0005506"(iron ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005604"(basement membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0006457"(protein folding)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0018126"(protein hydroxylation)|go:"GO:0019797"(procollagen-proline 3-dioxygenase activity)|go:"GO:0030199"(collagen fibril organization)|go:"GO:0030278"(regulation of ossification)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0031418"(L-ascorbic acid binding)|go:"GO:0032963"(collagen metabolic process)|go:"GO:0050708"(regulation of protein secretion)|go:"GO:0050821"(protein stabilization)|go:"GO:0060348"(bone development)|go:"GO:1901874"(negative regulation of post-translational protein modification)	-	-	-	caution:"The participant EBI-349571(P68370) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919386(Q7TP47) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920972(Q5XIP9) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-916419(P11980) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919578(Q8R491) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920554(Q5U3Z7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920647(Q5U2X8) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920585(Q7TP24) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-779677(P05426) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-915744(P02454) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|agonist:Insulin was shown to increase or decrease GLUT4 protein interactions in specific cases.|comment:"Insulin decreased GLUT4 interactions with the following proteins: Q9ER30 (Sarcosin), P09527 (Rab-7), O88960 (N-ethylmaleimide sensitive), P09456 (PKA I regulatory subunit), P27881 (Hexokinase type II), P07872 (Acyl-coenzyme A oxidase), Q6DGF1 (Isocitrate dehydrogenase), Q9EQX9 (Ubiquitin-conjugating), Q63446 (Polyubiquitin), P24268 (Cathepsin D), Q91XW0 (Heat shock protein 86), Q5FVH0 (unknown), P58405 (Striatin 3), Q62667 (Major vault protein), Q66H50 (unknown), Q09167 (splicing factor), Q9JHU5 (Arfaptin 1)."|comment:"Insulin increased GLUT4 interaction with the following proteins:Q9Z1P2 (R-actinin-1), P45592 (Cofilin), Q9QXQ0 (R-actinin-4), P26473 (ADP-ribosylation factor), P26437 (ADP-ribosylation factor),   Q7TNP1 (Basigin 2), Q6P6R2 (Dihydrolipoamide dehydrogenase),   P04797 (GAPDH), Q63081 (Protein disulfide isomerase), P29457 (47 kDa heat shock protein), Q9R1J8 (Leprecan), O88638 (Putative eps protein),   Q64375 (Synaptonemal complex)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:NDPK - Interactions involving proteins containing InterPro domain IPR001564, Nucleoside diphosphate kinase, core.	taxid:10116(rat-l6)|taxid:10116(Rattus norvegicus)	-	2006/02/15	2021/11/30	rogid:PbFY2lfrty8yw40Jq7ShR7xfuV410116	rogid:SO8oCO6mKIkocjBkiJiKTwbeKAA10116	intact-crc:44F3A2176D02515F|rigid:9RVm0UBcqQF4k06RGKO89Bg16Q8	false	myc tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P19357	uniprotkb:Q9R063	intact:EBI-915426|uniprotkb:P97900|ensembl:ENSRNOP00000023256	intact:EBI-920143|uniprotkb:Q68G22	psi-mi:glut4_rat(display_long)|uniprotkb:Glucose transporter type 4, insulin-responsive(gene name synonym)|uniprotkb:Slc2a4(gene name)|psi-mi:Slc2a4(display_short)|uniprotkb:Glut4(gene name synonym)	psi-mi:prdx5_rat(display_long)|uniprotkb:Prdx5(gene name)|psi-mi:Prdx5(display_short)|uniprotkb:Peroxiredoxin V(gene name synonym)|uniprotkb:Peroxisomal antioxidant enzyme(gene name synonym)|uniprotkb:PLP(gene name synonym)|uniprotkb:Thioredoxin peroxidase PMP20(gene name synonym)|uniprotkb:Antioxidant enzyme B166(gene name synonym)|uniprotkb:Thioredoxin-dependent peroxiredoxin 5(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Foster et al. (2006)	pubmed:16396496|mint:MINT-5218203	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-921030	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2711|refseq:NP_036883.1|refseq:XP_006246658.1|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007611"(learning or memory)|go:"GO:0007614"(short-term memory)|go:"GO:0007616"(long-term memory)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010021"(amylopectin biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031550"(positive regulation of brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044381"(glucose import in response to insulin stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046323"(glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0098694"(regulation of synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0098793"(presynapse)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002441("Glucose transporter, type 4 (GLUT4)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-189200|ensembl:ENSRNOG00000017226(gene)|ensembl:ENSRNOT00000023256(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)	rgd:71007|refseq:NP_446062.1|interpro:IPR013740(Redoxin)|interpro:IPR013766(Thioredoxin domain)|interpro:IPR037944|interpro:IPR036249|reactome:R-RNO-3299685|reactome:R-RNO-5628897|go:"GO:0001016"(RNA polymerase III transcription regulatory region sequence-specific DNA binding)|go:"GO:0004601"(peroxidase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005777"(peroxisome)|go:"GO:0005782"(peroxisomal matrix)|go:"GO:0005829"(cytosol)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0008379"(thioredoxin peroxidase activity)|go:"GO:0016480"(negative regulation of transcription by RNA polymerase III)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0034614"(cellular response to reactive oxygen species)|go:"GO:0042744"(hydrogen peroxide catabolic process)|go:"GO:0043027"(cysteine-type endopeptidase inhibitor activity involved in apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045454"(cell redox homeostasis)|go:"GO:0048471"(perinuclear region of cytoplasm)	-	-	-	caution:"The participant EBI-349571(P68370) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919386(Q7TP47) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920972(Q5XIP9) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-916419(P11980) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919578(Q8R491) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920554(Q5U3Z7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920647(Q5U2X8) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920585(Q7TP24) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-779677(P05426) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-915744(P02454) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|agonist:Insulin was shown to increase or decrease GLUT4 protein interactions in specific cases.|comment:"Insulin decreased GLUT4 interactions with the following proteins: Q9ER30 (Sarcosin), P09527 (Rab-7), O88960 (N-ethylmaleimide sensitive), P09456 (PKA I regulatory subunit), P27881 (Hexokinase type II), P07872 (Acyl-coenzyme A oxidase), Q6DGF1 (Isocitrate dehydrogenase), Q9EQX9 (Ubiquitin-conjugating), Q63446 (Polyubiquitin), P24268 (Cathepsin D), Q91XW0 (Heat shock protein 86), Q5FVH0 (unknown), P58405 (Striatin 3), Q62667 (Major vault protein), Q66H50 (unknown), Q09167 (splicing factor), Q9JHU5 (Arfaptin 1)."|comment:"Insulin increased GLUT4 interaction with the following proteins:Q9Z1P2 (R-actinin-1), P45592 (Cofilin), Q9QXQ0 (R-actinin-4), P26473 (ADP-ribosylation factor), P26437 (ADP-ribosylation factor),   Q7TNP1 (Basigin 2), Q6P6R2 (Dihydrolipoamide dehydrogenase),   P04797 (GAPDH), Q63081 (Protein disulfide isomerase), P29457 (47 kDa heat shock protein), Q9R1J8 (Leprecan), O88638 (Putative eps protein),   Q64375 (Synaptonemal complex)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:NDPK - Interactions involving proteins containing InterPro domain IPR001564, Nucleoside diphosphate kinase, core.	taxid:10116(rat-l6)|taxid:10116(Rattus norvegicus)	-	2006/02/15	2021/11/30	rogid:PbFY2lfrty8yw40Jq7ShR7xfuV410116	rogid:PU91iaHxS1CJKEfIW3qrIm4EU6A10116	intact-crc:44F3A2176D02515F|rigid:9RVm0UBcqQF4k06RGKO89Bg16Q8	false	myc tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P19357	uniprotkb:Q9QZV8	intact:EBI-915426|uniprotkb:P97900|ensembl:ENSRNOP00000023256	intact:EBI-920133	psi-mi:glut4_rat(display_long)|uniprotkb:Glucose transporter type 4, insulin-responsive(gene name synonym)|uniprotkb:Slc2a4(gene name)|psi-mi:Slc2a4(display_short)|uniprotkb:Glut4(gene name synonym)	psi-mi:q9qzv8_rat(display_long)|uniprotkb:MYHC(gene name)|psi-mi:MYHC(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Foster et al. (2006)	pubmed:16396496|mint:MINT-5218203	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-921030	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2711|refseq:NP_036883.1|refseq:XP_006246658.1|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007611"(learning or memory)|go:"GO:0007614"(short-term memory)|go:"GO:0007616"(long-term memory)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010021"(amylopectin biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031550"(positive regulation of brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044381"(glucose import in response to insulin stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046323"(glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0098694"(regulation of synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0098793"(presynapse)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002441("Glucose transporter, type 4 (GLUT4)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-189200|ensembl:ENSRNOG00000017226(gene)|ensembl:ENSRNOT00000023256(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)	interpro:IPR002928(Myosin tail)|interpro:IPR014751(DNA double-strand break repair and VJ recombination XRCC4, C-terminal)|go:"GO:0016459"(myosin complex)	-	-	-	caution:"The participant EBI-349571(P68370) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919386(Q7TP47) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920972(Q5XIP9) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-916419(P11980) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919578(Q8R491) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920554(Q5U3Z7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920647(Q5U2X8) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920585(Q7TP24) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-779677(P05426) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-915744(P02454) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|agonist:Insulin was shown to increase or decrease GLUT4 protein interactions in specific cases.|comment:"Insulin decreased GLUT4 interactions with the following proteins: Q9ER30 (Sarcosin), P09527 (Rab-7), O88960 (N-ethylmaleimide sensitive), P09456 (PKA I regulatory subunit), P27881 (Hexokinase type II), P07872 (Acyl-coenzyme A oxidase), Q6DGF1 (Isocitrate dehydrogenase), Q9EQX9 (Ubiquitin-conjugating), Q63446 (Polyubiquitin), P24268 (Cathepsin D), Q91XW0 (Heat shock protein 86), Q5FVH0 (unknown), P58405 (Striatin 3), Q62667 (Major vault protein), Q66H50 (unknown), Q09167 (splicing factor), Q9JHU5 (Arfaptin 1)."|comment:"Insulin increased GLUT4 interaction with the following proteins:Q9Z1P2 (R-actinin-1), P45592 (Cofilin), Q9QXQ0 (R-actinin-4), P26473 (ADP-ribosylation factor), P26437 (ADP-ribosylation factor),   Q7TNP1 (Basigin 2), Q6P6R2 (Dihydrolipoamide dehydrogenase),   P04797 (GAPDH), Q63081 (Protein disulfide isomerase), P29457 (47 kDa heat shock protein), Q9R1J8 (Leprecan), O88638 (Putative eps protein),   Q64375 (Synaptonemal complex)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:NDPK - Interactions involving proteins containing InterPro domain IPR001564, Nucleoside diphosphate kinase, core.	taxid:10116(rat-l6)|taxid:10116(Rattus norvegicus)	-	2006/02/15	2021/11/30	rogid:PbFY2lfrty8yw40Jq7ShR7xfuV410116	rogid:l56knoLIxARoVbIYfsdi9MdA7yM10116	intact-crc:44F3A2176D02515F|rigid:9RVm0UBcqQF4k06RGKO89Bg16Q8	false	myc tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P19357	uniprotkb:Q9QZR6	intact:EBI-915426|uniprotkb:P97900|ensembl:ENSRNOP00000023256	intact:EBI-920105|uniprotkb:Q9QZJ7|uniprotkb:Q9QZJ8|uniprotkb:Q9QZP9	psi-mi:glut4_rat(display_long)|uniprotkb:Glucose transporter type 4, insulin-responsive(gene name synonym)|uniprotkb:Slc2a4(gene name)|psi-mi:Slc2a4(display_short)|uniprotkb:Glut4(gene name synonym)	psi-mi:sept9_rat(display_long)|uniprotkb:Septin9(gene name)|psi-mi:Septin9(display_short)|uniprotkb:Eighth septin(gene name synonym)|uniprotkb:Eseptin(gene name synonym)|uniprotkb:Sept9(gene name synonym)|uniprotkb:Septin-like protein(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Foster et al. (2006)	pubmed:16396496|mint:MINT-5218203	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-921030	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2711|refseq:NP_036883.1|refseq:XP_006246658.1|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007611"(learning or memory)|go:"GO:0007614"(short-term memory)|go:"GO:0007616"(long-term memory)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010021"(amylopectin biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031550"(positive regulation of brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044381"(glucose import in response to insulin stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046323"(glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0098694"(regulation of synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0098793"(presynapse)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002441("Glucose transporter, type 4 (GLUT4)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-189200|ensembl:ENSRNOG00000017226(gene)|ensembl:ENSRNOT00000023256(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)	rgd:708523|refseq:NP_001106969.1|refseq:NP_114025.2|refseq:NP_789826.2|interpro:IPR016491(Septin)|interpro:IPR030379|interpro:IPR030645|interpro:IPR027417|go:"GO:0001725"(stress fiber)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005874"(microtubule)|go:"GO:0005930"(axoneme)|go:"GO:0005940"(septin ring)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0031105"(septin complex)|go:"GO:0032153"(cell division site)|go:"GO:0034613"(cellular protein localization)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0061640"(cytoskeleton-dependent cytokinesis)|go:"GO:0097730"(non-motile cilium)|go:"GO:1902857"(positive regulation of non-motile cilium assembly)	-	-	-	caution:"The participant EBI-349571(P68370) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919386(Q7TP47) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920972(Q5XIP9) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-916419(P11980) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919578(Q8R491) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920554(Q5U3Z7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920647(Q5U2X8) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920585(Q7TP24) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-779677(P05426) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-915744(P02454) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|agonist:Insulin was shown to increase or decrease GLUT4 protein interactions in specific cases.|comment:"Insulin decreased GLUT4 interactions with the following proteins: Q9ER30 (Sarcosin), P09527 (Rab-7), O88960 (N-ethylmaleimide sensitive), P09456 (PKA I regulatory subunit), P27881 (Hexokinase type II), P07872 (Acyl-coenzyme A oxidase), Q6DGF1 (Isocitrate dehydrogenase), Q9EQX9 (Ubiquitin-conjugating), Q63446 (Polyubiquitin), P24268 (Cathepsin D), Q91XW0 (Heat shock protein 86), Q5FVH0 (unknown), P58405 (Striatin 3), Q62667 (Major vault protein), Q66H50 (unknown), Q09167 (splicing factor), Q9JHU5 (Arfaptin 1)."|comment:"Insulin increased GLUT4 interaction with the following proteins:Q9Z1P2 (R-actinin-1), P45592 (Cofilin), Q9QXQ0 (R-actinin-4), P26473 (ADP-ribosylation factor), P26437 (ADP-ribosylation factor),   Q7TNP1 (Basigin 2), Q6P6R2 (Dihydrolipoamide dehydrogenase),   P04797 (GAPDH), Q63081 (Protein disulfide isomerase), P29457 (47 kDa heat shock protein), Q9R1J8 (Leprecan), O88638 (Putative eps protein),   Q64375 (Synaptonemal complex)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:NDPK - Interactions involving proteins containing InterPro domain IPR001564, Nucleoside diphosphate kinase, core.	taxid:10116(rat-l6)|taxid:10116(Rattus norvegicus)	-	2006/02/15	2021/11/30	rogid:PbFY2lfrty8yw40Jq7ShR7xfuV410116	rogid:YclaeSq4GzMcGZ9YwnkwUWKoXzY10116	intact-crc:44F3A2176D02515F|rigid:9RVm0UBcqQF4k06RGKO89Bg16Q8	false	myc tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P19357	uniprotkb:Q99N27	intact:EBI-915426|uniprotkb:P97900|ensembl:ENSRNOP00000023256	intact:EBI-919756|uniprotkb:Q56A25|ensembl:ENSRNOP00000022960	psi-mi:glut4_rat(display_long)|uniprotkb:Glucose transporter type 4, insulin-responsive(gene name synonym)|uniprotkb:Slc2a4(gene name)|psi-mi:Slc2a4(display_short)|uniprotkb:Glut4(gene name synonym)	psi-mi:snx1_rat(display_long)|uniprotkb:Snx1(gene name)|psi-mi:Snx1(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Foster et al. (2006)	pubmed:16396496|mint:MINT-5218203	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-921030	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2711|refseq:NP_036883.1|refseq:XP_006246658.1|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007611"(learning or memory)|go:"GO:0007614"(short-term memory)|go:"GO:0007616"(long-term memory)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010021"(amylopectin biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031550"(positive regulation of brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044381"(glucose import in response to insulin stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046323"(glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0098694"(regulation of synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0098793"(presynapse)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002441("Glucose transporter, type 4 (GLUT4)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-189200|ensembl:ENSRNOG00000017226(gene)|ensembl:ENSRNOT00000023256(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)	rgd:68935|refseq:NP_445863.1|ensembl:ENSRNOG00000017029(gene)|ensembl:ENSRNOT00000022960(transcript)|go:"GO:0005154"(epidermal growth factor receptor binding)|go:"GO:0005158"(insulin receptor binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005768"(endosome)|go:"GO:0005769"(early endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0010008"(endosome membrane)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016197"(endosomal transport)|go:"GO:0030027"(lamellipodium)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030904"(retromer complex)|go:"GO:0030905"(retromer, tubulation complex)|go:"GO:0031175"(neuron projection development)|go:"GO:0031623"(receptor internalization)|go:"GO:0031901"(early endosome membrane)|go:"GO:0031982"(vesicle)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034498"(early endosome to Golgi transport)|go:"GO:0035091"(phosphatidylinositol binding)|go:"GO:0042147"(retrograde transport, endosome to Golgi)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043197"(dendritic spine)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0072673"(lamellipodium morphogenesis)|go:"GO:0098793"(presynapse)|go:"GO:0098999"(extrinsic component of postsynaptic endosome membrane)|go:"GO:0099092"(postsynaptic density, intracellular component)|go:"GO:1990459"(transferrin receptor binding)|go:"GO:1990460"(leptin receptor binding)|interpro:IPR001683(Phox-like)|interpro:IPR005329(Sorting nexin, N-terminal)|interpro:IPR015404(Vps5 C terminal like)|interpro:IPR027267|interpro:IPR028660|interpro:IPR034901|interpro:IPR036871	-	-	-	caution:"The participant EBI-349571(P68370) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919386(Q7TP47) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920972(Q5XIP9) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-916419(P11980) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919578(Q8R491) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920554(Q5U3Z7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920647(Q5U2X8) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920585(Q7TP24) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-779677(P05426) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-915744(P02454) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|agonist:Insulin was shown to increase or decrease GLUT4 protein interactions in specific cases.|comment:"Insulin decreased GLUT4 interactions with the following proteins: Q9ER30 (Sarcosin), P09527 (Rab-7), O88960 (N-ethylmaleimide sensitive), P09456 (PKA I regulatory subunit), P27881 (Hexokinase type II), P07872 (Acyl-coenzyme A oxidase), Q6DGF1 (Isocitrate dehydrogenase), Q9EQX9 (Ubiquitin-conjugating), Q63446 (Polyubiquitin), P24268 (Cathepsin D), Q91XW0 (Heat shock protein 86), Q5FVH0 (unknown), P58405 (Striatin 3), Q62667 (Major vault protein), Q66H50 (unknown), Q09167 (splicing factor), Q9JHU5 (Arfaptin 1)."|comment:"Insulin increased GLUT4 interaction with the following proteins:Q9Z1P2 (R-actinin-1), P45592 (Cofilin), Q9QXQ0 (R-actinin-4), P26473 (ADP-ribosylation factor), P26437 (ADP-ribosylation factor),   Q7TNP1 (Basigin 2), Q6P6R2 (Dihydrolipoamide dehydrogenase),   P04797 (GAPDH), Q63081 (Protein disulfide isomerase), P29457 (47 kDa heat shock protein), Q9R1J8 (Leprecan), O88638 (Putative eps protein),   Q64375 (Synaptonemal complex)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:NDPK - Interactions involving proteins containing InterPro domain IPR001564, Nucleoside diphosphate kinase, core.	taxid:10116(rat-l6)|taxid:10116(Rattus norvegicus)	-	2006/02/15	2021/11/30	rogid:PbFY2lfrty8yw40Jq7ShR7xfuV410116	rogid:5GW8H7JahMy3HB2/KPleLPYJ9iE10116	intact-crc:44F3A2176D02515F|rigid:9RVm0UBcqQF4k06RGKO89Bg16Q8	false	myc tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P19357	uniprotkb:Q99J82	intact:EBI-915426|uniprotkb:P97900|ensembl:ENSRNOP00000023256	intact:EBI-919744|ensembl:ENSRNOP00000025906	psi-mi:glut4_rat(display_long)|uniprotkb:Glucose transporter type 4, insulin-responsive(gene name synonym)|uniprotkb:Slc2a4(gene name)|psi-mi:Slc2a4(display_short)|uniprotkb:Glut4(gene name synonym)	psi-mi:ilk_rat(display_long)|uniprotkb:Ilk(gene name)|psi-mi:Ilk(display_short)|uniprotkb:59 kDa serine/threonine-protein kinase(gene name synonym)|uniprotkb:Beta-integrin-linked kinase(gene name synonym)|uniprotkb:ILK-1(gene name synonym)|uniprotkb:ILK-2(gene name synonym)|uniprotkb:ILK1(gene name synonym)|uniprotkb:ILK2(gene name synonym)|uniprotkb:p59ILK(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Foster et al. (2006)	pubmed:16396496|mint:MINT-5218203	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-921030	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2711|refseq:NP_036883.1|refseq:XP_006246658.1|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007611"(learning or memory)|go:"GO:0007614"(short-term memory)|go:"GO:0007616"(long-term memory)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010021"(amylopectin biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031550"(positive regulation of brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044381"(glucose import in response to insulin stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046323"(glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0098694"(regulation of synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0098793"(presynapse)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002441("Glucose transporter, type 4 (GLUT4)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-189200|ensembl:ENSRNOG00000017226(gene)|ensembl:ENSRNOT00000023256(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)	rgd:620063|refseq:NP_596900.1|ensembl:ENSRNOG00000018993(gene)|ensembl:ENSRNOT00000025906(transcript)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0001658"(branching involved in ureteric bud morphogenesis)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0001954"(positive regulation of cell-matrix adhesion)|go:"GO:0003151"(outflow tract morphogenesis)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005178"(integrin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005925"(focal adhesion)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0007569"(cell aging)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009967"(positive regulation of signal transduction)|go:"GO:0010667"(negative regulation of cardiac muscle cell apoptotic process)|go:"GO:0010761"(fibroblast migration)|go:"GO:0014044"(Schwann cell development)|go:"GO:0014912"(negative regulation of smooth muscle cell migration)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0021675"(nerve development)|go:"GO:0022011"(myelination in peripheral nervous system)|go:"GO:0030017"(sarcomere)|go:"GO:0030027"(lamellipodium)|go:"GO:0030030"(cell projection organization)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030424"(axon)|go:"GO:0030513"(positive regulation of BMP signaling pathway)|go:"GO:0032288"(myelin assembly)|go:"GO:0032956"(regulation of actin cytoskeleton organization)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0034446"(substrate adhesion-dependent cell spreading)|go:"GO:0042327"(positive regulation of phosphorylation)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043034"(costamere)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043195"(terminal bouton)|go:"GO:0043198"(dendritic shaft)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045197"(establishment or maintenance of epithelial cell apical/basal polarity)|go:"GO:0045663"(positive regulation of myoblast differentiation)|go:"GO:0045669"(positive regulation of osteoblast differentiation)|go:"GO:0045773"(positive regulation of axon extension)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0048662"(negative regulation of smooth muscle cell proliferation)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0050772"(positive regulation of axonogenesis)|go:"GO:0050775"(positive regulation of dendrite morphogenesis)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0097435"(supramolecular fiber organization)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1900026"(positive regulation of substrate adhesion-dependent cell spreading)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:2000178"(negative regulation of neural precursor cell proliferation)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR002110(Ankyrin)|interpro:IPR011009(Protein kinase-like)|interpro:IPR020683|interpro:IPR035692|interpro:IPR036770|reactome:R-RNO-446343|reactome:R-RNO-446353	-	-	-	caution:"The participant EBI-349571(P68370) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919386(Q7TP47) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920972(Q5XIP9) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-916419(P11980) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919578(Q8R491) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920554(Q5U3Z7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920647(Q5U2X8) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920585(Q7TP24) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-779677(P05426) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-915744(P02454) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|agonist:Insulin was shown to increase or decrease GLUT4 protein interactions in specific cases.|comment:"Insulin decreased GLUT4 interactions with the following proteins: Q9ER30 (Sarcosin), P09527 (Rab-7), O88960 (N-ethylmaleimide sensitive), P09456 (PKA I regulatory subunit), P27881 (Hexokinase type II), P07872 (Acyl-coenzyme A oxidase), Q6DGF1 (Isocitrate dehydrogenase), Q9EQX9 (Ubiquitin-conjugating), Q63446 (Polyubiquitin), P24268 (Cathepsin D), Q91XW0 (Heat shock protein 86), Q5FVH0 (unknown), P58405 (Striatin 3), Q62667 (Major vault protein), Q66H50 (unknown), Q09167 (splicing factor), Q9JHU5 (Arfaptin 1)."|comment:"Insulin increased GLUT4 interaction with the following proteins:Q9Z1P2 (R-actinin-1), P45592 (Cofilin), Q9QXQ0 (R-actinin-4), P26473 (ADP-ribosylation factor), P26437 (ADP-ribosylation factor),   Q7TNP1 (Basigin 2), Q6P6R2 (Dihydrolipoamide dehydrogenase),   P04797 (GAPDH), Q63081 (Protein disulfide isomerase), P29457 (47 kDa heat shock protein), Q9R1J8 (Leprecan), O88638 (Putative eps protein),   Q64375 (Synaptonemal complex)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:NDPK - Interactions involving proteins containing InterPro domain IPR001564, Nucleoside diphosphate kinase, core.	taxid:10116(rat-l6)|taxid:10116(Rattus norvegicus)	-	2006/02/15	2021/11/30	rogid:PbFY2lfrty8yw40Jq7ShR7xfuV410116	rogid:9kMagkwUrtq1XaI+9PXPJ21hHY810116	intact-crc:44F3A2176D02515F|rigid:9RVm0UBcqQF4k06RGKO89Bg16Q8	false	myc tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P19357	uniprotkb:Q99068	intact:EBI-915426|uniprotkb:P97900|ensembl:ENSRNOP00000023256	intact:EBI-919734|uniprotkb:Q4FZX8|uniprotkb:Q642A1|uniprotkb:Q64723|ensembl:ENSRNOP00000012665	psi-mi:glut4_rat(display_long)|uniprotkb:Glucose transporter type 4, insulin-responsive(gene name synonym)|uniprotkb:Slc2a4(gene name)|psi-mi:Slc2a4(display_short)|uniprotkb:Glut4(gene name synonym)	psi-mi:amrp_rat(display_long)|uniprotkb:Lrpap1(gene name)|psi-mi:Lrpap1(display_short)|uniprotkb:Low density lipoprotein receptor-related protein-associated protein 1(gene name synonym)|uniprotkb:Gp330-binding 45 kDa protein(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Foster et al. (2006)	pubmed:16396496|mint:MINT-5218203	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-921030	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2711|refseq:NP_036883.1|refseq:XP_006246658.1|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007611"(learning or memory)|go:"GO:0007614"(short-term memory)|go:"GO:0007616"(long-term memory)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010021"(amylopectin biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031550"(positive regulation of brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044381"(glucose import in response to insulin stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046323"(glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0098694"(regulation of synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0098793"(presynapse)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002441("Glucose transporter, type 4 (GLUT4)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-189200|ensembl:ENSRNOG00000017226(gene)|ensembl:ENSRNOT00000023256(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)	rgd:620700|refseq:NP_001162584.1|ensembl:ENSRNOG00000009313(gene)|ensembl:ENSRNOT00000012665(transcript)|go:"GO:0002091"(negative regulation of receptor internalization)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0005793"(endoplasmic reticulum-Golgi intermediate compartment)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005796"(Golgi lumen)|go:"GO:0005801"(cis-Golgi network)|go:"GO:0005886"(plasma membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0008201"(heparin binding)|go:"GO:0009986"(cell surface)|go:"GO:0010916"(negative regulation of very-low-density lipoprotein particle clearance)|go:"GO:0012505"(endomembrane system)|go:"GO:0031904"(endosome lumen)|go:"GO:0031982"(vesicle)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0035473"(lipase binding)|go:"GO:0048018"(receptor ligand activity)|go:"GO:0048019"(receptor antagonist activity)|go:"GO:0048237"(rough endoplasmic reticulum lumen)|go:"GO:0048259"(regulation of receptor-mediated endocytosis)|go:"GO:0050750"(low-density lipoprotein particle receptor binding)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0070326"(very-low-density lipoprotein particle receptor binding)|go:"GO:0150093"(amyloid-beta clearance by transcytosis)|go:"GO:1900222"(negative regulation of amyloid-beta clearance)|interpro:IPR009066(Alpha-2-macroglobulin receptor-associated protein, domain 1)|interpro:IPR010483(Alpha-2-macroglobulin RAP, C-terminal)|interpro:IPR036744|interpro:IPR037999|interpro:IPR038001|interpro:IPR038003|mint:Q99068	-	-	-	caution:"The participant EBI-349571(P68370) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919386(Q7TP47) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920972(Q5XIP9) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-916419(P11980) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919578(Q8R491) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920554(Q5U3Z7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920647(Q5U2X8) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920585(Q7TP24) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-779677(P05426) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-915744(P02454) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|agonist:Insulin was shown to increase or decrease GLUT4 protein interactions in specific cases.|comment:"Insulin decreased GLUT4 interactions with the following proteins: Q9ER30 (Sarcosin), P09527 (Rab-7), O88960 (N-ethylmaleimide sensitive), P09456 (PKA I regulatory subunit), P27881 (Hexokinase type II), P07872 (Acyl-coenzyme A oxidase), Q6DGF1 (Isocitrate dehydrogenase), Q9EQX9 (Ubiquitin-conjugating), Q63446 (Polyubiquitin), P24268 (Cathepsin D), Q91XW0 (Heat shock protein 86), Q5FVH0 (unknown), P58405 (Striatin 3), Q62667 (Major vault protein), Q66H50 (unknown), Q09167 (splicing factor), Q9JHU5 (Arfaptin 1)."|comment:"Insulin increased GLUT4 interaction with the following proteins:Q9Z1P2 (R-actinin-1), P45592 (Cofilin), Q9QXQ0 (R-actinin-4), P26473 (ADP-ribosylation factor), P26437 (ADP-ribosylation factor),   Q7TNP1 (Basigin 2), Q6P6R2 (Dihydrolipoamide dehydrogenase),   P04797 (GAPDH), Q63081 (Protein disulfide isomerase), P29457 (47 kDa heat shock protein), Q9R1J8 (Leprecan), O88638 (Putative eps protein),   Q64375 (Synaptonemal complex)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:NDPK - Interactions involving proteins containing InterPro domain IPR001564, Nucleoside diphosphate kinase, core.	taxid:10116(rat-l6)|taxid:10116(Rattus norvegicus)	-	2006/02/15	2021/11/30	rogid:PbFY2lfrty8yw40Jq7ShR7xfuV410116	rogid:iCszi7bhiu3sGLgNv5dSIQ81m5Q10116	intact-crc:44F3A2176D02515F|rigid:9RVm0UBcqQF4k06RGKO89Bg16Q8	false	myc tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P19357	uniprotkb:Q924W3	intact:EBI-915426|uniprotkb:P97900|ensembl:ENSRNOP00000023256	intact:EBI-919727	psi-mi:glut4_rat(display_long)|uniprotkb:Glucose transporter type 4, insulin-responsive(gene name synonym)|uniprotkb:Slc2a4(gene name)|psi-mi:Slc2a4(display_short)|uniprotkb:Glut4(gene name synonym)	psi-mi:q924w3_rat(display_long)|uniprotkb:Itga6(gene name)|psi-mi:Itga6(display_short)|uniprotkb:inta6(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Foster et al. (2006)	pubmed:16396496|mint:MINT-5218203	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-921030	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2711|refseq:NP_036883.1|refseq:XP_006246658.1|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007611"(learning or memory)|go:"GO:0007614"(short-term memory)|go:"GO:0007616"(long-term memory)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010021"(amylopectin biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031550"(positive regulation of brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044381"(glucose import in response to insulin stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046323"(glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0098694"(regulation of synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0098793"(presynapse)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002441("Glucose transporter, type 4 (GLUT4)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-189200|ensembl:ENSRNOG00000017226(gene)|ensembl:ENSRNOT00000023256(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)	interpro:IPR028994|interpro:IPR013519(Integrin alpha beta-propellor)|rgd:621633|refseq:NP_446177.1|go:"GO:0005604"(basement membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0005912"(adherens junction)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0008305"(integrin complex)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009925"(basal plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010668"(ectodermal cell differentiation)|go:"GO:0010811"(positive regulation of cell-substrate adhesion)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0022409"(positive regulation of cell-cell adhesion)|go:"GO:0030056"(hemidesmosome)|go:"GO:0030175"(filopodium)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0031589"(cell-substrate adhesion)|go:"GO:0031668"(cellular response to extracellular stimulus)|go:"GO:0031994"(insulin-like growth factor I binding)|go:"GO:0034676"(integrin alpha6-beta4 complex)|go:"GO:0035878"(nail development)|go:"GO:0038132"(neuregulin binding)|go:"GO:0042327"(positive regulation of phosphorylation)|go:"GO:0042475"(odontogenesis of dentin-containing tooth)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043236"(laminin binding)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0043589"(skin morphogenesis)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045178"(basal part of cell)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046847"(filopodium assembly)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0050900"(leukocyte migration)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway)	-	-	-	caution:"The participant EBI-349571(P68370) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919386(Q7TP47) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920972(Q5XIP9) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-916419(P11980) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919578(Q8R491) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920554(Q5U3Z7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920647(Q5U2X8) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920585(Q7TP24) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-779677(P05426) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-915744(P02454) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|agonist:Insulin was shown to increase or decrease GLUT4 protein interactions in specific cases.|comment:"Insulin decreased GLUT4 interactions with the following proteins: Q9ER30 (Sarcosin), P09527 (Rab-7), O88960 (N-ethylmaleimide sensitive), P09456 (PKA I regulatory subunit), P27881 (Hexokinase type II), P07872 (Acyl-coenzyme A oxidase), Q6DGF1 (Isocitrate dehydrogenase), Q9EQX9 (Ubiquitin-conjugating), Q63446 (Polyubiquitin), P24268 (Cathepsin D), Q91XW0 (Heat shock protein 86), Q5FVH0 (unknown), P58405 (Striatin 3), Q62667 (Major vault protein), Q66H50 (unknown), Q09167 (splicing factor), Q9JHU5 (Arfaptin 1)."|comment:"Insulin increased GLUT4 interaction with the following proteins:Q9Z1P2 (R-actinin-1), P45592 (Cofilin), Q9QXQ0 (R-actinin-4), P26473 (ADP-ribosylation factor), P26437 (ADP-ribosylation factor),   Q7TNP1 (Basigin 2), Q6P6R2 (Dihydrolipoamide dehydrogenase),   P04797 (GAPDH), Q63081 (Protein disulfide isomerase), P29457 (47 kDa heat shock protein), Q9R1J8 (Leprecan), O88638 (Putative eps protein),   Q64375 (Synaptonemal complex)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:NDPK - Interactions involving proteins containing InterPro domain IPR001564, Nucleoside diphosphate kinase, core.	taxid:10116(rat-l6)|taxid:10116(Rattus norvegicus)	-	2006/02/15	2021/11/30	rogid:PbFY2lfrty8yw40Jq7ShR7xfuV410116	rogid:OHNzw/Gpk3WnDwivOouMxzSTs6010116	intact-crc:44F3A2176D02515F|rigid:9RVm0UBcqQF4k06RGKO89Bg16Q8	false	myc tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P19357	uniprotkb:Q924S5	intact:EBI-915426|uniprotkb:P97900|ensembl:ENSRNOP00000023256	intact:EBI-919708|ensembl:ENSRNOP00000066618	psi-mi:glut4_rat(display_long)|uniprotkb:Glucose transporter type 4, insulin-responsive(gene name synonym)|uniprotkb:Slc2a4(gene name)|psi-mi:Slc2a4(display_short)|uniprotkb:Glut4(gene name synonym)	psi-mi:lonm_rat(display_long)|uniprotkb:Lonp1(gene name)|psi-mi:Lonp1(display_short)|uniprotkb:Lon(gene name synonym)|uniprotkb:Lon protease-like protein(gene name synonym)|uniprotkb:Mitochondrial ATP-dependent protease Lon(gene name synonym)|uniprotkb:Serine protease 15(gene name synonym)|uniprotkb:Prss15(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Foster et al. (2006)	pubmed:16396496|mint:MINT-5218203	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-921030	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2711|refseq:NP_036883.1|refseq:XP_006246658.1|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007611"(learning or memory)|go:"GO:0007614"(short-term memory)|go:"GO:0007616"(long-term memory)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010021"(amylopectin biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031550"(positive regulation of brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044381"(glucose import in response to insulin stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046323"(glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0098694"(regulation of synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0098793"(presynapse)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002441("Glucose transporter, type 4 (GLUT4)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-189200|ensembl:ENSRNOG00000017226(gene)|ensembl:ENSRNOT00000023256(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)	rgd:621598|refseq:NP_596895.1|ensembl:ENSRNOG00000046502(gene)|ensembl:ENSRNOT00000074253(transcript)|go:"GO:0001018"(mitochondrial promoter sequence-specific DNA binding)|go:"GO:0001666"(response to hypoxia)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0003727"(single-stranded RNA binding)|go:"GO:0004176"(ATP-dependent peptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005829"(cytosol)|go:"GO:0006508"(proteolysis)|go:"GO:0006515"(protein quality control for misfolded or incompletely synthesized proteins)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0007568"(aging)|go:"GO:0009725"(response to hormone)|go:"GO:0010044"(response to aluminum ion)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0034622"|go:"GO:0042645"(mitochondrial nucleoid)|go:"GO:0042802"(identical protein binding)|go:"GO:0043531"(ADP binding)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0051131"(chaperone-mediated protein complex assembly)|go:"GO:0051603"(proteolysis involved in cellular protein catabolic process)|go:"GO:0051880"(G-quadruplex DNA binding)|go:"GO:0070182"(DNA polymerase binding)|go:"GO:0070407"(oxidation-dependent protein catabolic process)|interpro:IPR003111(Peptidase S16, lon N-terminal)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR003959(AAA ATPase, core)|interpro:IPR004815(Peptidase S16, ATP-dependent protease La)|interpro:IPR008268(Peptidase S16, active site)|interpro:IPR008269(Peptidase S16, lon C-terminal)|interpro:IPR014721(Ribosomal protein S5 domain 2-type fold)|interpro:IPR015947(PUA-like)|interpro:IPR020568|interpro:IPR027065|interpro:IPR027417|interpro:IPR027503	-	-	-	caution:"The participant EBI-349571(P68370) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919386(Q7TP47) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920972(Q5XIP9) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-916419(P11980) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919578(Q8R491) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920554(Q5U3Z7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920647(Q5U2X8) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920585(Q7TP24) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-779677(P05426) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-915744(P02454) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|agonist:Insulin was shown to increase or decrease GLUT4 protein interactions in specific cases.|comment:"Insulin decreased GLUT4 interactions with the following proteins: Q9ER30 (Sarcosin), P09527 (Rab-7), O88960 (N-ethylmaleimide sensitive), P09456 (PKA I regulatory subunit), P27881 (Hexokinase type II), P07872 (Acyl-coenzyme A oxidase), Q6DGF1 (Isocitrate dehydrogenase), Q9EQX9 (Ubiquitin-conjugating), Q63446 (Polyubiquitin), P24268 (Cathepsin D), Q91XW0 (Heat shock protein 86), Q5FVH0 (unknown), P58405 (Striatin 3), Q62667 (Major vault protein), Q66H50 (unknown), Q09167 (splicing factor), Q9JHU5 (Arfaptin 1)."|comment:"Insulin increased GLUT4 interaction with the following proteins:Q9Z1P2 (R-actinin-1), P45592 (Cofilin), Q9QXQ0 (R-actinin-4), P26473 (ADP-ribosylation factor), P26437 (ADP-ribosylation factor),   Q7TNP1 (Basigin 2), Q6P6R2 (Dihydrolipoamide dehydrogenase),   P04797 (GAPDH), Q63081 (Protein disulfide isomerase), P29457 (47 kDa heat shock protein), Q9R1J8 (Leprecan), O88638 (Putative eps protein),   Q64375 (Synaptonemal complex)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:NDPK - Interactions involving proteins containing InterPro domain IPR001564, Nucleoside diphosphate kinase, core.	taxid:10116(rat-l6)|taxid:10116(Rattus norvegicus)	-	2006/02/15	2021/11/30	rogid:PbFY2lfrty8yw40Jq7ShR7xfuV410116	rogid:B+QE/rt7togEktkWfLIgKvyDvI410116	intact-crc:44F3A2176D02515F|rigid:9RVm0UBcqQF4k06RGKO89Bg16Q8	false	myc tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P19357	uniprotkb:Q924M6	intact:EBI-915426|uniprotkb:P97900|ensembl:ENSRNOP00000023256	intact:EBI-919700	psi-mi:glut4_rat(display_long)|uniprotkb:Glucose transporter type 4, insulin-responsive(gene name synonym)|uniprotkb:Slc2a4(gene name)|psi-mi:Slc2a4(display_short)|uniprotkb:Glut4(gene name synonym)	psi-mi:q924m6_rat(display_long)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Foster et al. (2006)	pubmed:16396496|mint:MINT-5218203	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-921030	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2711|refseq:NP_036883.1|refseq:XP_006246658.1|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007611"(learning or memory)|go:"GO:0007614"(short-term memory)|go:"GO:0007616"(long-term memory)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010021"(amylopectin biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031550"(positive regulation of brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044381"(glucose import in response to insulin stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046323"(glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0098694"(regulation of synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0098793"(presynapse)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002441("Glucose transporter, type 4 (GLUT4)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-189200|ensembl:ENSRNOG00000017226(gene)|ensembl:ENSRNOT00000023256(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)	interpro:IPR029324|interpro:IPR032773|interpro:IPR016156(FAD/NAD-linked reductase, dimerisation)|interpro:IPR023753|interpro:IPR036188|go:"GO:0005739"(mitochondrion)|go:"GO:0006915"(apoptotic process)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016491"(oxidoreductase activity)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0050660"(flavin adenine dinucleotide binding)	-	-	-	caution:"The participant EBI-349571(P68370) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919386(Q7TP47) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920972(Q5XIP9) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-916419(P11980) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919578(Q8R491) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920554(Q5U3Z7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920647(Q5U2X8) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920585(Q7TP24) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-779677(P05426) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-915744(P02454) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|agonist:Insulin was shown to increase or decrease GLUT4 protein interactions in specific cases.|comment:"Insulin decreased GLUT4 interactions with the following proteins: Q9ER30 (Sarcosin), P09527 (Rab-7), O88960 (N-ethylmaleimide sensitive), P09456 (PKA I regulatory subunit), P27881 (Hexokinase type II), P07872 (Acyl-coenzyme A oxidase), Q6DGF1 (Isocitrate dehydrogenase), Q9EQX9 (Ubiquitin-conjugating), Q63446 (Polyubiquitin), P24268 (Cathepsin D), Q91XW0 (Heat shock protein 86), Q5FVH0 (unknown), P58405 (Striatin 3), Q62667 (Major vault protein), Q66H50 (unknown), Q09167 (splicing factor), Q9JHU5 (Arfaptin 1)."|comment:"Insulin increased GLUT4 interaction with the following proteins:Q9Z1P2 (R-actinin-1), P45592 (Cofilin), Q9QXQ0 (R-actinin-4), P26473 (ADP-ribosylation factor), P26437 (ADP-ribosylation factor),   Q7TNP1 (Basigin 2), Q6P6R2 (Dihydrolipoamide dehydrogenase),   P04797 (GAPDH), Q63081 (Protein disulfide isomerase), P29457 (47 kDa heat shock protein), Q9R1J8 (Leprecan), O88638 (Putative eps protein),   Q64375 (Synaptonemal complex)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:NDPK - Interactions involving proteins containing InterPro domain IPR001564, Nucleoside diphosphate kinase, core.	taxid:10116(rat-l6)|taxid:10116(Rattus norvegicus)	-	2006/02/15	2021/11/30	rogid:PbFY2lfrty8yw40Jq7ShR7xfuV410116	rogid:brAWkLCYTf+WiZ9Voefkz6PRu7810116	intact-crc:44F3A2176D02515F|rigid:9RVm0UBcqQF4k06RGKO89Bg16Q8	false	myc tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P19357	uniprotkb:Q923V8	intact:EBI-915426|uniprotkb:P97900|ensembl:ENSRNOP00000023256	intact:EBI-919690	psi-mi:glut4_rat(display_long)|uniprotkb:Glucose transporter type 4, insulin-responsive(gene name synonym)|uniprotkb:Slc2a4(gene name)|psi-mi:Slc2a4(display_short)|uniprotkb:Glut4(gene name synonym)	psi-mi:sep15_rat(display_long)|uniprotkb:Selenof(gene name)|psi-mi:Selenof(display_short)|uniprotkb:15 kDa selenoprotein(gene name synonym)|uniprotkb:Sep15(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Foster et al. (2006)	pubmed:16396496|mint:MINT-5218203	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-921030	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2711|refseq:NP_036883.1|refseq:XP_006246658.1|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007611"(learning or memory)|go:"GO:0007614"(short-term memory)|go:"GO:0007616"(long-term memory)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010021"(amylopectin biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031550"(positive regulation of brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044381"(glucose import in response to insulin stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046323"(glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0098694"(regulation of synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0098793"(presynapse)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002441("Glucose transporter, type 4 (GLUT4)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-189200|ensembl:ENSRNOG00000017226(gene)|ensembl:ENSRNOT00000023256(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)	rgd:621291|refseq:NP_579831.2|interpro:IPR014912(Sep15/SelM redox)|interpro:IPR038219|interpro:IPR036249|interpro:IPR039992|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0008379"(thioredoxin peroxidase activity)|go:"GO:0008430"(selenium binding)|go:"GO:0016491"(oxidoreductase activity)|go:"GO:0035092"(sperm DNA condensation)|go:"GO:0051084"('de novo' posttranslational protein folding)	-	-	-	caution:"The participant EBI-349571(P68370) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919386(Q7TP47) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920972(Q5XIP9) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-916419(P11980) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919578(Q8R491) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920554(Q5U3Z7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920647(Q5U2X8) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920585(Q7TP24) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-779677(P05426) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-915744(P02454) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|agonist:Insulin was shown to increase or decrease GLUT4 protein interactions in specific cases.|comment:"Insulin decreased GLUT4 interactions with the following proteins: Q9ER30 (Sarcosin), P09527 (Rab-7), O88960 (N-ethylmaleimide sensitive), P09456 (PKA I regulatory subunit), P27881 (Hexokinase type II), P07872 (Acyl-coenzyme A oxidase), Q6DGF1 (Isocitrate dehydrogenase), Q9EQX9 (Ubiquitin-conjugating), Q63446 (Polyubiquitin), P24268 (Cathepsin D), Q91XW0 (Heat shock protein 86), Q5FVH0 (unknown), P58405 (Striatin 3), Q62667 (Major vault protein), Q66H50 (unknown), Q09167 (splicing factor), Q9JHU5 (Arfaptin 1)."|comment:"Insulin increased GLUT4 interaction with the following proteins:Q9Z1P2 (R-actinin-1), P45592 (Cofilin), Q9QXQ0 (R-actinin-4), P26473 (ADP-ribosylation factor), P26437 (ADP-ribosylation factor),   Q7TNP1 (Basigin 2), Q6P6R2 (Dihydrolipoamide dehydrogenase),   P04797 (GAPDH), Q63081 (Protein disulfide isomerase), P29457 (47 kDa heat shock protein), Q9R1J8 (Leprecan), O88638 (Putative eps protein),   Q64375 (Synaptonemal complex)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:NDPK - Interactions involving proteins containing InterPro domain IPR001564, Nucleoside diphosphate kinase, core.	taxid:10116(rat-l6)|taxid:10116(Rattus norvegicus)	-	2006/02/15	2021/11/30	rogid:PbFY2lfrty8yw40Jq7ShR7xfuV410116	rogid:leKsiE4/JKFHWYBmQodOtfucD2Q10116	intact-crc:44F3A2176D02515F|rigid:9RVm0UBcqQF4k06RGKO89Bg16Q8	false	myc tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P19357	uniprotkb:Q920L2	intact:EBI-915426|uniprotkb:P97900|ensembl:ENSRNOP00000023256	intact:EBI-919680|ensembl:ENSRNOP00000018336	psi-mi:glut4_rat(display_long)|uniprotkb:Glucose transporter type 4, insulin-responsive(gene name synonym)|uniprotkb:Slc2a4(gene name)|psi-mi:Slc2a4(display_short)|uniprotkb:Glut4(gene name synonym)	psi-mi:sdha_rat(display_long)|uniprotkb:Sdha(gene name)|psi-mi:Sdha(display_short)|uniprotkb:Flavoprotein subunit of complex II(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Foster et al. (2006)	pubmed:16396496|mint:MINT-5218203	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-921030	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2711|refseq:NP_036883.1|refseq:XP_006246658.1|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007611"(learning or memory)|go:"GO:0007614"(short-term memory)|go:"GO:0007616"(long-term memory)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010021"(amylopectin biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031550"(positive regulation of brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044381"(glucose import in response to insulin stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046323"(glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0098694"(regulation of synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0098793"(presynapse)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002441("Glucose transporter, type 4 (GLUT4)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-189200|ensembl:ENSRNOG00000017226(gene)|ensembl:ENSRNOT00000023256(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)	rgd:621557|refseq:NP_569112.1|ensembl:ENSRNOG00000013331(gene)|ensembl:ENSRNOT00000018336(transcript)|go:"GO:0000104"(succinate dehydrogenase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005749"("mitochondrial respiratory chain complex II, succinate dehydrogenase complex (ubiquinone)")|go:"GO:0006099"(tricarboxylic acid cycle)|go:"GO:0006105"(succinate metabolic process)|go:"GO:0006121"(mitochondrial electron transport, succinate to ubiquinone)|go:"GO:0007399"(nervous system development)|go:"GO:0008177"("succinate dehydrogenase (ubiquinone) activity")|go:"GO:0009055"(electron transfer activity)|go:"GO:0022904"(respiratory electron transport chain)|go:"GO:0050660"(flavin adenine dinucleotide binding)|interpro:IPR003952(Fumarate reductase/succinate dehydrogenase, FAD-binding site)|interpro:IPR003953(Fumarate reductase/succinate dehydrogenase flavoprotein, N-terminal)|interpro:IPR011281(Succinate dehydrogenase, flavoprotein subunit)|interpro:IPR014006(Succinate dehydrogenase or fumarate reductase, flavoprotein subunit)|interpro:IPR015939(Fumarate reductase/succinate dehydrogenase flavoprotein-like, C-terminal)|interpro:IPR027477|interpro:IPR036188|interpro:IPR037099|reactome:R-RNO-71403	-	-	-	caution:"The participant EBI-349571(P68370) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919386(Q7TP47) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920972(Q5XIP9) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-916419(P11980) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919578(Q8R491) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920554(Q5U3Z7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920647(Q5U2X8) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920585(Q7TP24) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-779677(P05426) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-915744(P02454) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|agonist:Insulin was shown to increase or decrease GLUT4 protein interactions in specific cases.|comment:"Insulin decreased GLUT4 interactions with the following proteins: Q9ER30 (Sarcosin), P09527 (Rab-7), O88960 (N-ethylmaleimide sensitive), P09456 (PKA I regulatory subunit), P27881 (Hexokinase type II), P07872 (Acyl-coenzyme A oxidase), Q6DGF1 (Isocitrate dehydrogenase), Q9EQX9 (Ubiquitin-conjugating), Q63446 (Polyubiquitin), P24268 (Cathepsin D), Q91XW0 (Heat shock protein 86), Q5FVH0 (unknown), P58405 (Striatin 3), Q62667 (Major vault protein), Q66H50 (unknown), Q09167 (splicing factor), Q9JHU5 (Arfaptin 1)."|comment:"Insulin increased GLUT4 interaction with the following proteins:Q9Z1P2 (R-actinin-1), P45592 (Cofilin), Q9QXQ0 (R-actinin-4), P26473 (ADP-ribosylation factor), P26437 (ADP-ribosylation factor),   Q7TNP1 (Basigin 2), Q6P6R2 (Dihydrolipoamide dehydrogenase),   P04797 (GAPDH), Q63081 (Protein disulfide isomerase), P29457 (47 kDa heat shock protein), Q9R1J8 (Leprecan), O88638 (Putative eps protein),   Q64375 (Synaptonemal complex)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:NDPK - Interactions involving proteins containing InterPro domain IPR001564, Nucleoside diphosphate kinase, core.	taxid:10116(rat-l6)|taxid:10116(Rattus norvegicus)	-	2006/02/15	2021/11/30	rogid:PbFY2lfrty8yw40Jq7ShR7xfuV410116	rogid:NycnM+3Hj8W0DWKfEpyYpGPzULQ10116	intact-crc:44F3A2176D02515F|rigid:9RVm0UBcqQF4k06RGKO89Bg16Q8	false	myc tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P19357	uniprotkb:Q920J4	intact:EBI-915426|uniprotkb:P97900|ensembl:ENSRNOP00000023256	intact:EBI-919671|ensembl:ENSRNOP00000025510	psi-mi:glut4_rat(display_long)|uniprotkb:Glucose transporter type 4, insulin-responsive(gene name synonym)|uniprotkb:Slc2a4(gene name)|psi-mi:Slc2a4(display_short)|uniprotkb:Glut4(gene name synonym)	psi-mi:txnl1_rat(display_long)|uniprotkb:Txnl1(gene name)|psi-mi:Txnl1(display_short)|uniprotkb:Trp(gene name synonym)|uniprotkb:Thioredoxin-related protein(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Foster et al. (2006)	pubmed:16396496|mint:MINT-5218203	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-921030	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2711|refseq:NP_036883.1|refseq:XP_006246658.1|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007611"(learning or memory)|go:"GO:0007614"(short-term memory)|go:"GO:0007616"(long-term memory)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010021"(amylopectin biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031550"(positive regulation of brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044381"(glucose import in response to insulin stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046323"(glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0098694"(regulation of synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0098793"(presynapse)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002441("Glucose transporter, type 4 (GLUT4)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-189200|ensembl:ENSRNOG00000017226(gene)|ensembl:ENSRNOT00000023256(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)	rgd:621717|refseq:NP_543163.1|ensembl:ENSRNOG00000018818(gene)|ensembl:ENSRNOT00000025510(transcript)|go:"GO:0000502"(proteasome complex)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0015036"(disulfide oxidoreductase activity)|interpro:IPR008979(Galactose-binding like)|interpro:IPR010400(Protein of unknown function DUF1000)|interpro:IPR013766(Thioredoxin domain)|interpro:IPR017937|interpro:IPR036249|interpro:IPR037047|mint:Q920J4|reactome:R-RNO-9013418|reactome:R-RNO-9013420|reactome:R-RNO-9013422|reactome:R-RNO-9013424|reactome:R-RNO-9696264|reactome:R-RNO-9696270|reactome:R-RNO-9696273	-	-	-	caution:"The participant EBI-349571(P68370) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919386(Q7TP47) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920972(Q5XIP9) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-916419(P11980) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919578(Q8R491) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920554(Q5U3Z7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920647(Q5U2X8) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920585(Q7TP24) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-779677(P05426) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-915744(P02454) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|agonist:Insulin was shown to increase or decrease GLUT4 protein interactions in specific cases.|comment:"Insulin decreased GLUT4 interactions with the following proteins: Q9ER30 (Sarcosin), P09527 (Rab-7), O88960 (N-ethylmaleimide sensitive), P09456 (PKA I regulatory subunit), P27881 (Hexokinase type II), P07872 (Acyl-coenzyme A oxidase), Q6DGF1 (Isocitrate dehydrogenase), Q9EQX9 (Ubiquitin-conjugating), Q63446 (Polyubiquitin), P24268 (Cathepsin D), Q91XW0 (Heat shock protein 86), Q5FVH0 (unknown), P58405 (Striatin 3), Q62667 (Major vault protein), Q66H50 (unknown), Q09167 (splicing factor), Q9JHU5 (Arfaptin 1)."|comment:"Insulin increased GLUT4 interaction with the following proteins:Q9Z1P2 (R-actinin-1), P45592 (Cofilin), Q9QXQ0 (R-actinin-4), P26473 (ADP-ribosylation factor), P26437 (ADP-ribosylation factor),   Q7TNP1 (Basigin 2), Q6P6R2 (Dihydrolipoamide dehydrogenase),   P04797 (GAPDH), Q63081 (Protein disulfide isomerase), P29457 (47 kDa heat shock protein), Q9R1J8 (Leprecan), O88638 (Putative eps protein),   Q64375 (Synaptonemal complex)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:NDPK - Interactions involving proteins containing InterPro domain IPR001564, Nucleoside diphosphate kinase, core.	taxid:10116(rat-l6)|taxid:10116(Rattus norvegicus)	-	2006/02/15	2021/11/30	rogid:PbFY2lfrty8yw40Jq7ShR7xfuV410116	rogid:IdNjjpvOQpzmS+Tl8dmfF9O9yk010116	intact-crc:44F3A2176D02515F|rigid:9RVm0UBcqQF4k06RGKO89Bg16Q8	false	myc tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P19357	uniprotkb:Q920A6	intact:EBI-915426|uniprotkb:P97900|ensembl:ENSRNOP00000023256	intact:EBI-919661|ensembl:ENSRNOP00000003219	psi-mi:glut4_rat(display_long)|uniprotkb:Glucose transporter type 4, insulin-responsive(gene name synonym)|uniprotkb:Slc2a4(gene name)|psi-mi:Slc2a4(display_short)|uniprotkb:Glut4(gene name synonym)	psi-mi:risc_rat(display_long)|uniprotkb:Scpep1(gene name)|psi-mi:Scpep1(display_short)|uniprotkb:Risc(gene name synonym)|uniprotkb:Serine carboxypeptidase 1(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Foster et al. (2006)	pubmed:16396496|mint:MINT-5218203	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-921030	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2711|refseq:NP_036883.1|refseq:XP_006246658.1|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007611"(learning or memory)|go:"GO:0007614"(short-term memory)|go:"GO:0007616"(long-term memory)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010021"(amylopectin biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031550"(positive regulation of brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044381"(glucose import in response to insulin stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046323"(glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0098694"(regulation of synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0098793"(presynapse)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002441("Glucose transporter, type 4 (GLUT4)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-189200|ensembl:ENSRNOG00000017226(gene)|ensembl:ENSRNOT00000023256(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)	rgd:620067|refseq:NP_596874.1|ensembl:ENSRNOG00000002358(gene)|ensembl:ENSRNOT00000003219(transcript)|go:"GO:0004185"(serine-type carboxypeptidase activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005829"(cytosol)|go:"GO:0042573"(retinoic acid metabolic process)|go:"GO:0045776"(negative regulation of blood pressure)|go:"GO:0097746"(blood vessel diameter maintenance)|interpro:IPR001563(Peptidase S10, serine carboxypeptidase)|interpro:IPR018202|interpro:IPR029058	-	-	-	caution:"The participant EBI-349571(P68370) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919386(Q7TP47) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920972(Q5XIP9) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-916419(P11980) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919578(Q8R491) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920554(Q5U3Z7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920647(Q5U2X8) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920585(Q7TP24) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-779677(P05426) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-915744(P02454) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|agonist:Insulin was shown to increase or decrease GLUT4 protein interactions in specific cases.|comment:"Insulin decreased GLUT4 interactions with the following proteins: Q9ER30 (Sarcosin), P09527 (Rab-7), O88960 (N-ethylmaleimide sensitive), P09456 (PKA I regulatory subunit), P27881 (Hexokinase type II), P07872 (Acyl-coenzyme A oxidase), Q6DGF1 (Isocitrate dehydrogenase), Q9EQX9 (Ubiquitin-conjugating), Q63446 (Polyubiquitin), P24268 (Cathepsin D), Q91XW0 (Heat shock protein 86), Q5FVH0 (unknown), P58405 (Striatin 3), Q62667 (Major vault protein), Q66H50 (unknown), Q09167 (splicing factor), Q9JHU5 (Arfaptin 1)."|comment:"Insulin increased GLUT4 interaction with the following proteins:Q9Z1P2 (R-actinin-1), P45592 (Cofilin), Q9QXQ0 (R-actinin-4), P26473 (ADP-ribosylation factor), P26437 (ADP-ribosylation factor),   Q7TNP1 (Basigin 2), Q6P6R2 (Dihydrolipoamide dehydrogenase),   P04797 (GAPDH), Q63081 (Protein disulfide isomerase), P29457 (47 kDa heat shock protein), Q9R1J8 (Leprecan), O88638 (Putative eps protein),   Q64375 (Synaptonemal complex)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:NDPK - Interactions involving proteins containing InterPro domain IPR001564, Nucleoside diphosphate kinase, core.	taxid:10116(rat-l6)|taxid:10116(Rattus norvegicus)	-	2006/02/15	2021/11/30	rogid:PbFY2lfrty8yw40Jq7ShR7xfuV410116	rogid:rGq9nH5tL8qd7usukhN/ycdzAFg10116	intact-crc:44F3A2176D02515F|rigid:9RVm0UBcqQF4k06RGKO89Bg16Q8	false	myc tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P19357	uniprotkb:Q91ZW6	intact:EBI-915426|uniprotkb:P97900|ensembl:ENSRNOP00000023256	intact:EBI-919651|uniprotkb:Q5U2P7|ensembl:ENSRNOP00000068322	psi-mi:glut4_rat(display_long)|uniprotkb:Glucose transporter type 4, insulin-responsive(gene name synonym)|uniprotkb:Slc2a4(gene name)|psi-mi:Slc2a4(display_short)|uniprotkb:Glut4(gene name synonym)	psi-mi:tmlh_rat(display_long)|uniprotkb:Tmlhe(gene name)|psi-mi:Tmlhe(display_short)|uniprotkb:Tmlh(gene name synonym)|uniprotkb:Epsilon-trimethyllysine 2-oxoglutarate dioxygenase(gene name synonym)|uniprotkb:TML-alpha-ketoglutarate dioxygenase(gene name synonym)|uniprotkb:TML hydroxylase(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Foster et al. (2006)	pubmed:16396496|mint:MINT-5218203	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-921030	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2711|refseq:NP_036883.1|refseq:XP_006246658.1|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007611"(learning or memory)|go:"GO:0007614"(short-term memory)|go:"GO:0007616"(long-term memory)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010021"(amylopectin biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031550"(positive regulation of brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044381"(glucose import in response to insulin stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046323"(glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0098694"(regulation of synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0098793"(presynapse)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002441("Glucose transporter, type 4 (GLUT4)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-189200|ensembl:ENSRNOG00000017226(gene)|ensembl:ENSRNOT00000023256(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)	rgd:620629|refseq:NP_596878.2|refseq:XP_006255917.1|ensembl:ENSRNOG00000000729(gene)|ensembl:ENSRNOT00000076655(transcript)|go:"GO:0005506"(iron ion binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0016702"(oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen)|go:"GO:0045329"(carnitine biosynthetic process)|go:"GO:0050353"(trimethyllysine dioxygenase activity)|interpro:IPR003819(Taurine catabolism dioxygenase TauD/TfdA)|interpro:IPR010376(Protein of unknown function DUF971)|interpro:IPR012776(Trimethyllysine dioxygenase)|interpro:IPR038492|interpro:IPR042098|reactome:R-RNO-71262	-	-	-	caution:"The participant EBI-349571(P68370) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919386(Q7TP47) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920972(Q5XIP9) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-916419(P11980) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919578(Q8R491) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920554(Q5U3Z7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920647(Q5U2X8) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920585(Q7TP24) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-779677(P05426) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-915744(P02454) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|agonist:Insulin was shown to increase or decrease GLUT4 protein interactions in specific cases.|comment:"Insulin decreased GLUT4 interactions with the following proteins: Q9ER30 (Sarcosin), P09527 (Rab-7), O88960 (N-ethylmaleimide sensitive), P09456 (PKA I regulatory subunit), P27881 (Hexokinase type II), P07872 (Acyl-coenzyme A oxidase), Q6DGF1 (Isocitrate dehydrogenase), Q9EQX9 (Ubiquitin-conjugating), Q63446 (Polyubiquitin), P24268 (Cathepsin D), Q91XW0 (Heat shock protein 86), Q5FVH0 (unknown), P58405 (Striatin 3), Q62667 (Major vault protein), Q66H50 (unknown), Q09167 (splicing factor), Q9JHU5 (Arfaptin 1)."|comment:"Insulin increased GLUT4 interaction with the following proteins:Q9Z1P2 (R-actinin-1), P45592 (Cofilin), Q9QXQ0 (R-actinin-4), P26473 (ADP-ribosylation factor), P26437 (ADP-ribosylation factor),   Q7TNP1 (Basigin 2), Q6P6R2 (Dihydrolipoamide dehydrogenase),   P04797 (GAPDH), Q63081 (Protein disulfide isomerase), P29457 (47 kDa heat shock protein), Q9R1J8 (Leprecan), O88638 (Putative eps protein),   Q64375 (Synaptonemal complex)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:NDPK - Interactions involving proteins containing InterPro domain IPR001564, Nucleoside diphosphate kinase, core.	taxid:10116(rat-l6)|taxid:10116(Rattus norvegicus)	-	2006/02/15	2021/11/30	rogid:PbFY2lfrty8yw40Jq7ShR7xfuV410116	rogid:TqhzzWI7y2tzhwtvJu23ZQN3sck10116	intact-crc:44F3A2176D02515F|rigid:9RVm0UBcqQF4k06RGKO89Bg16Q8	false	myc tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P19357	uniprotkb:Q91Y81	intact:EBI-915426|uniprotkb:P97900|ensembl:ENSRNOP00000023256	intact:EBI-919641|ensembl:ENSRNOP00000024261	psi-mi:glut4_rat(display_long)|uniprotkb:Glucose transporter type 4, insulin-responsive(gene name synonym)|uniprotkb:Slc2a4(gene name)|psi-mi:Slc2a4(display_short)|uniprotkb:Glut4(gene name synonym)	psi-mi:sept2_rat(display_long)|uniprotkb:Septin2(gene name)|psi-mi:Septin2(display_short)|uniprotkb:Sept2(gene name synonym)|uniprotkb:Vascular endothelial cell specific protein 11(gene name synonym)|uniprotkb:Vesp11(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Foster et al. (2006)	pubmed:16396496|mint:MINT-5218203	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-921030	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2711|refseq:NP_036883.1|refseq:XP_006246658.1|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007611"(learning or memory)|go:"GO:0007614"(short-term memory)|go:"GO:0007616"(long-term memory)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010021"(amylopectin biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031550"(positive regulation of brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044381"(glucose import in response to insulin stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046323"(glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0098694"(regulation of synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0098793"(presynapse)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002441("Glucose transporter, type 4 (GLUT4)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-189200|ensembl:ENSRNOG00000017226(gene)|ensembl:ENSRNOT00000023256(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)	rgd:620056|refseq:NP_476489.1|refseq:XP_006245574.1|refseq:XP_006245576.1|ensembl:ENSRNOG00000017952(gene)|ensembl:ENSRNOT00000024261(transcript)|go:"GO:0000145"(exocyst)|go:"GO:0002036"(regulation of L-glutamate import across plasma membrane)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005819"(spindle)|go:"GO:0005886"(plasma membrane)|go:"GO:0005930"(axoneme)|go:"GO:0005940"(septin ring)|go:"GO:0007224"(smoothened signaling pathway)|go:"GO:0007283"(spermatogenesis)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0009986"(cell surface)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0017157"(regulation of exocytosis)|go:"GO:0030234"(enzyme regulator activity)|go:"GO:0030496"(midbody)|go:"GO:0031105"(septin complex)|go:"GO:0031175"(neuron projection development)|go:"GO:0032153"(cell division site)|go:"GO:0032154"(cleavage furrow)|go:"GO:0032391"(photoreceptor connecting cilium)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0034613"(cellular protein localization)|go:"GO:0035869"(ciliary transition zone)|go:"GO:0042995"(cell projection)|go:"GO:0045171"(intercellular bridge)|go:"GO:0045202"(synapse)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060271"(cilium assembly)|go:"GO:0061640"(cytoskeleton-dependent cytokinesis)|go:"GO:0097227"(sperm annulus)|go:"GO:0097730"(non-motile cilium)|interpro:IPR008113(Septin 2)|interpro:IPR016491(Septin)|interpro:IPR027417|interpro:IPR030379|mint:Q91Y81|reactome:R-RNO-5620912	-	-	-	caution:"The participant EBI-349571(P68370) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919386(Q7TP47) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920972(Q5XIP9) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-916419(P11980) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919578(Q8R491) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920554(Q5U3Z7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920647(Q5U2X8) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920585(Q7TP24) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-779677(P05426) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-915744(P02454) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|agonist:Insulin was shown to increase or decrease GLUT4 protein interactions in specific cases.|comment:"Insulin decreased GLUT4 interactions with the following proteins: Q9ER30 (Sarcosin), P09527 (Rab-7), O88960 (N-ethylmaleimide sensitive), P09456 (PKA I regulatory subunit), P27881 (Hexokinase type II), P07872 (Acyl-coenzyme A oxidase), Q6DGF1 (Isocitrate dehydrogenase), Q9EQX9 (Ubiquitin-conjugating), Q63446 (Polyubiquitin), P24268 (Cathepsin D), Q91XW0 (Heat shock protein 86), Q5FVH0 (unknown), P58405 (Striatin 3), Q62667 (Major vault protein), Q66H50 (unknown), Q09167 (splicing factor), Q9JHU5 (Arfaptin 1)."|comment:"Insulin increased GLUT4 interaction with the following proteins:Q9Z1P2 (R-actinin-1), P45592 (Cofilin), Q9QXQ0 (R-actinin-4), P26473 (ADP-ribosylation factor), P26437 (ADP-ribosylation factor),   Q7TNP1 (Basigin 2), Q6P6R2 (Dihydrolipoamide dehydrogenase),   P04797 (GAPDH), Q63081 (Protein disulfide isomerase), P29457 (47 kDa heat shock protein), Q9R1J8 (Leprecan), O88638 (Putative eps protein),   Q64375 (Synaptonemal complex)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:NDPK - Interactions involving proteins containing InterPro domain IPR001564, Nucleoside diphosphate kinase, core.	taxid:10116(rat-l6)|taxid:10116(Rattus norvegicus)	-	2006/02/15	2021/11/30	rogid:PbFY2lfrty8yw40Jq7ShR7xfuV410116	rogid:ISmHgWzsvHDKuSUbTF9FtBqAfA810116	intact-crc:44F3A2176D02515F|rigid:9RVm0UBcqQF4k06RGKO89Bg16Q8	false	myc tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P19357	uniprotkb:P82995	intact:EBI-915426|uniprotkb:P97900|ensembl:ENSRNOP00000023256	intact:EBI-919629|uniprotkb:Q91XW0|ensembl:ENSRNOP00000009556|ensembl:ENSRNOP00000075715	psi-mi:glut4_rat(display_long)|uniprotkb:Glucose transporter type 4, insulin-responsive(gene name synonym)|uniprotkb:Slc2a4(gene name)|psi-mi:Slc2a4(display_short)|uniprotkb:Glut4(gene name synonym)	psi-mi:hs90a_rat(display_long)|uniprotkb:Hsp90aa1(gene name)|psi-mi:Hsp90aa1(display_short)|uniprotkb:Hspca(gene name synonym)|uniprotkb:Heat shock 86 kDa(gene name synonym)|uniprotkb:Hsp86(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Foster et al. (2006)	pubmed:16396496|mint:MINT-5218203	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-921030	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2711|refseq:NP_036883.1|refseq:XP_006246658.1|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007611"(learning or memory)|go:"GO:0007614"(short-term memory)|go:"GO:0007616"(long-term memory)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010021"(amylopectin biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031550"(positive regulation of brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044381"(glucose import in response to insulin stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046323"(glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0098694"(regulation of synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0098793"(presynapse)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002441("Glucose transporter, type 4 (GLUT4)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-189200|ensembl:ENSRNOG00000017226(gene)|ensembl:ENSRNOT00000023256(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)	refseq:XP_008763191.1|rgd:631409|refseq:NP_786937.1|ensembl:ENSRNOG00000007219(gene)|ensembl:ENSRNOG00000059714(gene)|ensembl:ENSRNOT00000009556(transcript)|ensembl:ENSRNOT00000086310(transcript)|go:"GO:0001764"(neuron migration)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002134"(UTP binding)|go:"GO:0002135"(CTP binding)|go:"GO:0002218"(activation of innate immune response)|go:"GO:0002230"(positive regulation of defense response to virus by host)|go:"GO:0003009"(skeletal muscle contraction)|go:"GO:0003729"(mRNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005525"(GTP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006457"(protein folding)|go:"GO:0007004"(telomere maintenance via telomerase)|go:"GO:0009408"(response to heat)|go:"GO:0009409"(response to cold)|go:"GO:0009651"(response to salt stress)|go:"GO:0009986"(cell surface)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010659"(cardiac muscle cell apoptotic process)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0017098"(sulfonylurea receptor binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0021955"(central nervous system neuron axonogenesis)|go:"GO:0030010"(establishment of cell polarity)|go:"GO:0030235"(nitric-oxide synthase regulator activity)|go:"GO:0030911"(TPR domain binding)|go:"GO:0031396"(regulation of protein ubiquitination)|go:"GO:0031526"(brush border membrane)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032273"(positive regulation of protein polymerization)|go:"GO:0032564"(dATP binding)|go:"GO:0032728"(positive regulation of interferon-beta production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0034605"(cellular response to heat)|go:"GO:0036126"(sperm flagellum)|go:"GO:0042220"(response to cocaine)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0042470"(melanosome)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043202"(lysosomal lumen)|go:"GO:0043209"(myelin sheath)|go:"GO:0043627"(response to estrogen)|go:"GO:0044183"(protein folding chaperone)|go:"GO:0044294"(dendritic growth cone)|go:"GO:0044295"(axonal growth cone)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0045040"(protein insertion into mitochondrial outer membrane)|go:"GO:0045429"(positive regulation of nitric oxide biosynthetic process)|go:"GO:0045793"(positive regulation of cell size)|go:"GO:0046677"(response to antibiotic)|go:"GO:0048156"(tau protein binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048675"(axon extension)|go:"GO:0050821"(protein stabilization)|go:"GO:0051020"(GTPase binding)|go:"GO:0051022"(Rho GDP-dissociation inhibitor binding)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051131"(chaperone-mediated protein complex assembly)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0051973"(positive regulation of telomerase activity)|go:"GO:0060452"(positive regulation of cardiac muscle contraction)|go:"GO:0061635"(regulation of protein complex stability)|go:"GO:0061684"(chaperone-mediated autophagy)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070182"(DNA polymerase binding)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097226"(sperm mitochondrial sheath)|go:"GO:0097524"(sperm plasma membrane)|go:"GO:0097718"(disordered domain specific binding)|go:"GO:0098586"(cellular response to virus)|go:"GO:0140597"(protein carrier chaperone)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1902949"(positive regulation of tau-protein kinase activity)|go:"GO:1903364"(positive regulation of cellular protein catabolic process)|go:"GO:1903827"|go:"GO:1905323"(telomerase holoenzyme complex assembly)|go:"GO:1990782"(protein tyrosine kinase binding)|interpro:IPR001404(Heat shock protein Hsp90)|interpro:IPR003594(ATP-binding region, ATPase-like)|interpro:IPR019805|interpro:IPR020568|interpro:IPR020575|interpro:IPR036890|interpro:IPR037196|mint:P82995|reactome:R-RNO-1227986|reactome:R-RNO-1474151|reactome:R-RNO-168928|reactome:R-RNO-2029482|reactome:R-RNO-203615|reactome:R-RNO-2565942|reactome:R-RNO-3371497|reactome:R-RNO-3371511|reactome:R-RNO-3371568|reactome:R-RNO-3371571|reactome:R-RNO-380259|reactome:R-RNO-380270|reactome:R-RNO-380284|reactome:R-RNO-380320|reactome:R-RNO-399954|reactome:R-RNO-4420097|reactome:R-RNO-5218920|reactome:R-RNO-5620912|reactome:R-RNO-5675482|reactome:R-RNO-6798695|reactome:R-RNO-8852276|reactome:R-RNO-8854518|reactome:R-RNO-8863795|reactome:R-RNO-8939211|reactome:R-RNO-9009391|reactome:R-RNO-9013418|reactome:R-RNO-9018519|reactome:R-RNO-9652282	-	-	-	caution:"The participant EBI-349571(P68370) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919386(Q7TP47) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920972(Q5XIP9) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-916419(P11980) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919578(Q8R491) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920554(Q5U3Z7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920647(Q5U2X8) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920585(Q7TP24) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-779677(P05426) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-915744(P02454) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|agonist:Insulin was shown to increase or decrease GLUT4 protein interactions in specific cases.|comment:"Insulin decreased GLUT4 interactions with the following proteins: Q9ER30 (Sarcosin), P09527 (Rab-7), O88960 (N-ethylmaleimide sensitive), P09456 (PKA I regulatory subunit), P27881 (Hexokinase type II), P07872 (Acyl-coenzyme A oxidase), Q6DGF1 (Isocitrate dehydrogenase), Q9EQX9 (Ubiquitin-conjugating), Q63446 (Polyubiquitin), P24268 (Cathepsin D), Q91XW0 (Heat shock protein 86), Q5FVH0 (unknown), P58405 (Striatin 3), Q62667 (Major vault protein), Q66H50 (unknown), Q09167 (splicing factor), Q9JHU5 (Arfaptin 1)."|comment:"Insulin increased GLUT4 interaction with the following proteins:Q9Z1P2 (R-actinin-1), P45592 (Cofilin), Q9QXQ0 (R-actinin-4), P26473 (ADP-ribosylation factor), P26437 (ADP-ribosylation factor),   Q7TNP1 (Basigin 2), Q6P6R2 (Dihydrolipoamide dehydrogenase),   P04797 (GAPDH), Q63081 (Protein disulfide isomerase), P29457 (47 kDa heat shock protein), Q9R1J8 (Leprecan), O88638 (Putative eps protein),   Q64375 (Synaptonemal complex)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:NDPK - Interactions involving proteins containing InterPro domain IPR001564, Nucleoside diphosphate kinase, core.	taxid:10116(rat-l6)|taxid:10116(Rattus norvegicus)	-	2006/02/15	2021/11/30	rogid:PbFY2lfrty8yw40Jq7ShR7xfuV410116	rogid:tqpvMNNqRR42cL/lpXrgcqJh0NE10116	intact-crc:44F3A2176D02515F|rigid:9RVm0UBcqQF4k06RGKO89Bg16Q8	false	myc tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P19357	uniprotkb:Q91XL4	intact:EBI-915426|uniprotkb:P97900|ensembl:ENSRNOP00000023256	intact:EBI-919624	psi-mi:glut4_rat(display_long)|uniprotkb:Glucose transporter type 4, insulin-responsive(gene name synonym)|uniprotkb:Slc2a4(gene name)|psi-mi:Slc2a4(display_short)|uniprotkb:Glut4(gene name synonym)	psi-mi:q91xl4_rat(display_long)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Foster et al. (2006)	pubmed:16396496|mint:MINT-5218203	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-921030	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2711|refseq:NP_036883.1|refseq:XP_006246658.1|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007611"(learning or memory)|go:"GO:0007614"(short-term memory)|go:"GO:0007616"(long-term memory)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010021"(amylopectin biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031550"(positive regulation of brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044381"(glucose import in response to insulin stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046323"(glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0098694"(regulation of synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0098793"(presynapse)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002441("Glucose transporter, type 4 (GLUT4)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-189200|ensembl:ENSRNOG00000017226(gene)|ensembl:ENSRNOT00000023256(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)	interpro:IPR016346(Guanine nucleotide-binding protein, beta subunit)|interpro:IPR020472|interpro:IPR001632(G-protein, beta subunit)|interpro:IPR001680(WD40 repeat)|interpro:IPR019775|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR036322|go:"GO:0007165"(signal transduction)	-	-	-	caution:"The participant EBI-349571(P68370) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919386(Q7TP47) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920972(Q5XIP9) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-916419(P11980) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919578(Q8R491) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920554(Q5U3Z7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920647(Q5U2X8) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920585(Q7TP24) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-779677(P05426) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-915744(P02454) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|agonist:Insulin was shown to increase or decrease GLUT4 protein interactions in specific cases.|comment:"Insulin decreased GLUT4 interactions with the following proteins: Q9ER30 (Sarcosin), P09527 (Rab-7), O88960 (N-ethylmaleimide sensitive), P09456 (PKA I regulatory subunit), P27881 (Hexokinase type II), P07872 (Acyl-coenzyme A oxidase), Q6DGF1 (Isocitrate dehydrogenase), Q9EQX9 (Ubiquitin-conjugating), Q63446 (Polyubiquitin), P24268 (Cathepsin D), Q91XW0 (Heat shock protein 86), Q5FVH0 (unknown), P58405 (Striatin 3), Q62667 (Major vault protein), Q66H50 (unknown), Q09167 (splicing factor), Q9JHU5 (Arfaptin 1)."|comment:"Insulin increased GLUT4 interaction with the following proteins:Q9Z1P2 (R-actinin-1), P45592 (Cofilin), Q9QXQ0 (R-actinin-4), P26473 (ADP-ribosylation factor), P26437 (ADP-ribosylation factor),   Q7TNP1 (Basigin 2), Q6P6R2 (Dihydrolipoamide dehydrogenase),   P04797 (GAPDH), Q63081 (Protein disulfide isomerase), P29457 (47 kDa heat shock protein), Q9R1J8 (Leprecan), O88638 (Putative eps protein),   Q64375 (Synaptonemal complex)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:NDPK - Interactions involving proteins containing InterPro domain IPR001564, Nucleoside diphosphate kinase, core.	taxid:10116(rat-l6)|taxid:10116(Rattus norvegicus)	-	2006/02/15	2021/11/30	rogid:PbFY2lfrty8yw40Jq7ShR7xfuV410116	rogid:4UOERdo+whhoymu6gjFPkr2Yb6g10116	intact-crc:44F3A2176D02515F|rigid:9RVm0UBcqQF4k06RGKO89Bg16Q8	false	myc tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P19357	uniprotkb:Q8VHV7	intact:EBI-915426|uniprotkb:P97900|ensembl:ENSRNOP00000023256	intact:EBI-919615|uniprotkb:A1L1J1	psi-mi:glut4_rat(display_long)|uniprotkb:Glucose transporter type 4, insulin-responsive(gene name synonym)|uniprotkb:Slc2a4(gene name)|psi-mi:Slc2a4(display_short)|uniprotkb:Glut4(gene name synonym)	psi-mi:hnrh1_rat(display_long)|uniprotkb:Hnrnph1(gene name)|psi-mi:Hnrnph1(display_short)|uniprotkb:Ratsg1(gene name synonym)|uniprotkb:Hnrph1(gene name synonym)|uniprotkb:Hnrph(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Foster et al. (2006)	pubmed:16396496|mint:MINT-5218203	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-921030	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2711|refseq:NP_036883.1|refseq:XP_006246658.1|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007611"(learning or memory)|go:"GO:0007614"(short-term memory)|go:"GO:0007616"(long-term memory)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010021"(amylopectin biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031550"(positive regulation of brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044381"(glucose import in response to insulin stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046323"(glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0098694"(regulation of synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0098793"(presynapse)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002441("Glucose transporter, type 4 (GLUT4)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-189200|ensembl:ENSRNOG00000017226(gene)|ensembl:ENSRNOT00000023256(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)	rgd:620840|refseq:NP_543172.1|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR012996(Zinc finger, CHHC-type)|mint:Q8VHV7|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR035979|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006396"(RNA processing)|go:"GO:0006397"(mRNA processing)|go:"GO:0008380"(RNA splicing)|go:"GO:0014069"(postsynaptic density)|go:"GO:0019899"(enzyme binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0043484"(regulation of RNA splicing)|go:"GO:0071013"(catalytic step 2 spliceosome)|go:"GO:0098761"(cellular response to interleukin-7)|go:"GO:1901653"(cellular response to peptide)|go:"GO:1990904"(ribonucleoprotein complex)|reactome:R-RNO-6803529|reactome:R-RNO-72163	-	-	-	caution:"The participant EBI-349571(P68370) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919386(Q7TP47) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920972(Q5XIP9) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-916419(P11980) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919578(Q8R491) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920554(Q5U3Z7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920647(Q5U2X8) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920585(Q7TP24) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-779677(P05426) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-915744(P02454) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|agonist:Insulin was shown to increase or decrease GLUT4 protein interactions in specific cases.|comment:"Insulin decreased GLUT4 interactions with the following proteins: Q9ER30 (Sarcosin), P09527 (Rab-7), O88960 (N-ethylmaleimide sensitive), P09456 (PKA I regulatory subunit), P27881 (Hexokinase type II), P07872 (Acyl-coenzyme A oxidase), Q6DGF1 (Isocitrate dehydrogenase), Q9EQX9 (Ubiquitin-conjugating), Q63446 (Polyubiquitin), P24268 (Cathepsin D), Q91XW0 (Heat shock protein 86), Q5FVH0 (unknown), P58405 (Striatin 3), Q62667 (Major vault protein), Q66H50 (unknown), Q09167 (splicing factor), Q9JHU5 (Arfaptin 1)."|comment:"Insulin increased GLUT4 interaction with the following proteins:Q9Z1P2 (R-actinin-1), P45592 (Cofilin), Q9QXQ0 (R-actinin-4), P26473 (ADP-ribosylation factor), P26437 (ADP-ribosylation factor),   Q7TNP1 (Basigin 2), Q6P6R2 (Dihydrolipoamide dehydrogenase),   P04797 (GAPDH), Q63081 (Protein disulfide isomerase), P29457 (47 kDa heat shock protein), Q9R1J8 (Leprecan), O88638 (Putative eps protein),   Q64375 (Synaptonemal complex)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:NDPK - Interactions involving proteins containing InterPro domain IPR001564, Nucleoside diphosphate kinase, core.	taxid:10116(rat-l6)|taxid:10116(Rattus norvegicus)	-	2006/02/15	2021/11/30	rogid:PbFY2lfrty8yw40Jq7ShR7xfuV410116	rogid:afNAvozo2+6P9UdVJw/giQXs4QA10116	intact-crc:44F3A2176D02515F|rigid:9RVm0UBcqQF4k06RGKO89Bg16Q8	false	myc tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P19357	uniprotkb:Q8VHJ0	intact:EBI-915426|uniprotkb:P97900|ensembl:ENSRNOP00000023256	intact:EBI-919611	psi-mi:glut4_rat(display_long)|uniprotkb:Glucose transporter type 4, insulin-responsive(gene name synonym)|uniprotkb:Slc2a4(gene name)|psi-mi:Slc2a4(display_short)|uniprotkb:Glut4(gene name synonym)	psi-mi:q8vhj0_rat(display_long)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Foster et al. (2006)	pubmed:16396496|mint:MINT-5218203	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-921030	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2711|refseq:NP_036883.1|refseq:XP_006246658.1|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007611"(learning or memory)|go:"GO:0007614"(short-term memory)|go:"GO:0007616"(long-term memory)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010021"(amylopectin biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031550"(positive regulation of brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044381"(glucose import in response to insulin stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046323"(glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0098694"(regulation of synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0098793"(presynapse)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002441("Glucose transporter, type 4 (GLUT4)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-189200|ensembl:ENSRNOG00000017226(gene)|ensembl:ENSRNOT00000023256(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)	-	-	-	-	caution:"The participant EBI-349571(P68370) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919386(Q7TP47) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920972(Q5XIP9) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-916419(P11980) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919578(Q8R491) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920554(Q5U3Z7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920647(Q5U2X8) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920585(Q7TP24) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-779677(P05426) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-915744(P02454) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|agonist:Insulin was shown to increase or decrease GLUT4 protein interactions in specific cases.|comment:"Insulin decreased GLUT4 interactions with the following proteins: Q9ER30 (Sarcosin), P09527 (Rab-7), O88960 (N-ethylmaleimide sensitive), P09456 (PKA I regulatory subunit), P27881 (Hexokinase type II), P07872 (Acyl-coenzyme A oxidase), Q6DGF1 (Isocitrate dehydrogenase), Q9EQX9 (Ubiquitin-conjugating), Q63446 (Polyubiquitin), P24268 (Cathepsin D), Q91XW0 (Heat shock protein 86), Q5FVH0 (unknown), P58405 (Striatin 3), Q62667 (Major vault protein), Q66H50 (unknown), Q09167 (splicing factor), Q9JHU5 (Arfaptin 1)."|comment:"Insulin increased GLUT4 interaction with the following proteins:Q9Z1P2 (R-actinin-1), P45592 (Cofilin), Q9QXQ0 (R-actinin-4), P26473 (ADP-ribosylation factor), P26437 (ADP-ribosylation factor),   Q7TNP1 (Basigin 2), Q6P6R2 (Dihydrolipoamide dehydrogenase),   P04797 (GAPDH), Q63081 (Protein disulfide isomerase), P29457 (47 kDa heat shock protein), Q9R1J8 (Leprecan), O88638 (Putative eps protein),   Q64375 (Synaptonemal complex)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:NDPK - Interactions involving proteins containing InterPro domain IPR001564, Nucleoside diphosphate kinase, core.	taxid:10116(rat-l6)|taxid:10116(Rattus norvegicus)	-	2006/02/15	2021/11/30	rogid:PbFY2lfrty8yw40Jq7ShR7xfuV410116	rogid:UO8uJvfpO53ZIRtFi61neNUQoH410116	intact-crc:44F3A2176D02515F|rigid:9RVm0UBcqQF4k06RGKO89Bg16Q8	false	myc tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P19357	uniprotkb:Q8VHI8	intact:EBI-915426|uniprotkb:P97900|ensembl:ENSRNOP00000023256	intact:EBI-919606|ensembl:ENSRNOP00000028173	psi-mi:glut4_rat(display_long)|uniprotkb:Glucose transporter type 4, insulin-responsive(gene name synonym)|uniprotkb:Slc2a4(gene name)|psi-mi:Slc2a4(display_short)|uniprotkb:Glut4(gene name synonym)	psi-mi:sec20_rat(display_long)|uniprotkb:Bnip1(gene name)|psi-mi:Bnip1(display_short)|uniprotkb:Sec20l(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Foster et al. (2006)	pubmed:16396496|mint:MINT-5218203	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-921030	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2711|refseq:NP_036883.1|refseq:XP_006246658.1|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007611"(learning or memory)|go:"GO:0007614"(short-term memory)|go:"GO:0007616"(long-term memory)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010021"(amylopectin biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031550"(positive regulation of brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044381"(glucose import in response to insulin stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046323"(glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0098694"(regulation of synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0098793"(presynapse)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002441("Glucose transporter, type 4 (GLUT4)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-189200|ensembl:ENSRNOG00000017226(gene)|ensembl:ENSRNOT00000023256(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)	rgd:620799|refseq:NP_543173.1|ensembl:ENSRNOG00000020753(gene)|ensembl:ENSRNOT00000028173(transcript)|go:"GO:0005484"(SNAP receptor activity)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0006890"(retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum)|go:"GO:0006915"(apoptotic process)|go:"GO:0007029"(endoplasmic reticulum organization)|go:"GO:0014823"(response to activity)|go:"GO:0015031"(protein transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016320"(endoplasmic reticulum membrane fusion)|go:"GO:0030137"(COPI-coated vesicle)|go:"GO:0031201"(SNARE complex)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0042594"(response to starvation)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0090649"(response to oxygen-glucose deprivation)|interpro:IPR005606(Sec20)|reactome:R-RNO-6811434	-	-	-	caution:"The participant EBI-349571(P68370) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919386(Q7TP47) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920972(Q5XIP9) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-916419(P11980) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919578(Q8R491) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920554(Q5U3Z7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920647(Q5U2X8) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920585(Q7TP24) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-779677(P05426) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-915744(P02454) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|agonist:Insulin was shown to increase or decrease GLUT4 protein interactions in specific cases.|comment:"Insulin decreased GLUT4 interactions with the following proteins: Q9ER30 (Sarcosin), P09527 (Rab-7), O88960 (N-ethylmaleimide sensitive), P09456 (PKA I regulatory subunit), P27881 (Hexokinase type II), P07872 (Acyl-coenzyme A oxidase), Q6DGF1 (Isocitrate dehydrogenase), Q9EQX9 (Ubiquitin-conjugating), Q63446 (Polyubiquitin), P24268 (Cathepsin D), Q91XW0 (Heat shock protein 86), Q5FVH0 (unknown), P58405 (Striatin 3), Q62667 (Major vault protein), Q66H50 (unknown), Q09167 (splicing factor), Q9JHU5 (Arfaptin 1)."|comment:"Insulin increased GLUT4 interaction with the following proteins:Q9Z1P2 (R-actinin-1), P45592 (Cofilin), Q9QXQ0 (R-actinin-4), P26473 (ADP-ribosylation factor), P26437 (ADP-ribosylation factor),   Q7TNP1 (Basigin 2), Q6P6R2 (Dihydrolipoamide dehydrogenase),   P04797 (GAPDH), Q63081 (Protein disulfide isomerase), P29457 (47 kDa heat shock protein), Q9R1J8 (Leprecan), O88638 (Putative eps protein),   Q64375 (Synaptonemal complex)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:NDPK - Interactions involving proteins containing InterPro domain IPR001564, Nucleoside diphosphate kinase, core.	taxid:10116(rat-l6)|taxid:10116(Rattus norvegicus)	-	2006/02/15	2021/11/30	rogid:PbFY2lfrty8yw40Jq7ShR7xfuV410116	rogid:RKHaAFvTHKF4dSqJIjQhSg5w9AI10116	intact-crc:44F3A2176D02515F|rigid:9RVm0UBcqQF4k06RGKO89Bg16Q8	false	myc tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P19357	uniprotkb:Q8VHF5	intact:EBI-915426|uniprotkb:P97900|ensembl:ENSRNOP00000023256	intact:EBI-349285	psi-mi:glut4_rat(display_long)|uniprotkb:Glucose transporter type 4, insulin-responsive(gene name synonym)|uniprotkb:Slc2a4(gene name)|psi-mi:Slc2a4(display_short)|uniprotkb:Glut4(gene name synonym)	psi-mi:cisy_rat(display_long)|uniprotkb:Cs(gene name)|psi-mi:Cs(display_short)|uniprotkb:"Citrate (Si)-synthase"(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Foster et al. (2006)	pubmed:16396496|mint:MINT-5218203	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-921030	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2711|refseq:NP_036883.1|refseq:XP_006246658.1|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007611"(learning or memory)|go:"GO:0007614"(short-term memory)|go:"GO:0007616"(long-term memory)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010021"(amylopectin biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031550"(positive regulation of brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044381"(glucose import in response to insulin stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046323"(glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0098694"(regulation of synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0098793"(presynapse)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002441("Glucose transporter, type 4 (GLUT4)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-189200|ensembl:ENSRNOG00000017226(gene)|ensembl:ENSRNOT00000023256(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)	rgd:620330|refseq:NP_570111.1|interpro:IPR016142(Citrate synthase-like, large alpha subdomain)|interpro:IPR002020(Citrate synthase-like)|interpro:IPR019810|interpro:IPR010109(Citrate synthase, eukaryotic)|go:"GO:0004108"("citrate (Si)-synthase activity")|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005975"(carbohydrate metabolic process)|go:"GO:0006084"(acetyl-CoA metabolic process)|go:"GO:0006099"(tricarboxylic acid cycle)|go:"GO:0006101"(citrate metabolic process)|go:"GO:0006107"(oxaloacetate metabolic process)|go:"GO:0046912"(acyltransferase, acyl groups converted into alkyl on transfer)|reactome:R-RNO-71403|interpro:IPR016143(Citrate synthase-like, small alpha subdomain)|mint:Q8VHF5|interpro:IPR036969	-	-	-	caution:"The participant EBI-349571(P68370) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919386(Q7TP47) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920972(Q5XIP9) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-916419(P11980) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919578(Q8R491) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920554(Q5U3Z7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920647(Q5U2X8) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920585(Q7TP24) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-779677(P05426) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-915744(P02454) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|agonist:Insulin was shown to increase or decrease GLUT4 protein interactions in specific cases.|comment:"Insulin decreased GLUT4 interactions with the following proteins: Q9ER30 (Sarcosin), P09527 (Rab-7), O88960 (N-ethylmaleimide sensitive), P09456 (PKA I regulatory subunit), P27881 (Hexokinase type II), P07872 (Acyl-coenzyme A oxidase), Q6DGF1 (Isocitrate dehydrogenase), Q9EQX9 (Ubiquitin-conjugating), Q63446 (Polyubiquitin), P24268 (Cathepsin D), Q91XW0 (Heat shock protein 86), Q5FVH0 (unknown), P58405 (Striatin 3), Q62667 (Major vault protein), Q66H50 (unknown), Q09167 (splicing factor), Q9JHU5 (Arfaptin 1)."|comment:"Insulin increased GLUT4 interaction with the following proteins:Q9Z1P2 (R-actinin-1), P45592 (Cofilin), Q9QXQ0 (R-actinin-4), P26473 (ADP-ribosylation factor), P26437 (ADP-ribosylation factor),   Q7TNP1 (Basigin 2), Q6P6R2 (Dihydrolipoamide dehydrogenase),   P04797 (GAPDH), Q63081 (Protein disulfide isomerase), P29457 (47 kDa heat shock protein), Q9R1J8 (Leprecan), O88638 (Putative eps protein),   Q64375 (Synaptonemal complex)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:NDPK - Interactions involving proteins containing InterPro domain IPR001564, Nucleoside diphosphate kinase, core.	taxid:10116(rat-l6)|taxid:10116(Rattus norvegicus)	-	2006/02/15	2021/11/30	rogid:PbFY2lfrty8yw40Jq7ShR7xfuV410116	rogid:3c3FZwuqQofmxnE7JYrd/zmEHec10116	intact-crc:44F3A2176D02515F|rigid:9RVm0UBcqQF4k06RGKO89Bg16Q8	false	myc tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P19357	uniprotkb:Q5XIP0	intact:EBI-915426|uniprotkb:P97900|ensembl:ENSRNOP00000023256	intact:EBI-920407|uniprotkb:F1LNN0|ensembl:ENSRNOP00000017381|ensembl:ENSRNOP00000075386	psi-mi:glut4_rat(display_long)|uniprotkb:Glucose transporter type 4, insulin-responsive(gene name synonym)|uniprotkb:Slc2a4(gene name)|psi-mi:Slc2a4(display_short)|uniprotkb:Glut4(gene name synonym)	psi-mi:q5xip0_rat(display_long)|uniprotkb:Dnajb4(gene name)|psi-mi:Dnajb4(display_short)|uniprotkb:rCG_28476(orf name)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Foster et al. (2006)	pubmed:16396496|mint:MINT-5218203	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-921030	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2711|refseq:NP_036883.1|refseq:XP_006246658.1|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007611"(learning or memory)|go:"GO:0007614"(short-term memory)|go:"GO:0007616"(long-term memory)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010021"(amylopectin biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031550"(positive regulation of brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044381"(glucose import in response to insulin stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046323"(glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0098694"(regulation of synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0098793"(presynapse)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002441("Glucose transporter, type 4 (GLUT4)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-189200|ensembl:ENSRNOG00000017226(gene)|ensembl:ENSRNOT00000023256(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)	rgd:1305826|refseq:NP_001013094.1|refseq:XP_008759772.1|refseq:XP_006233550.1|interpro:IPR008971(HSP40/DnaJ peptide-binding)|interpro:IPR018253|interpro:IPR036869|ensembl:ENSRNOG00000013011(gene)|ensembl:ENSRNOT00000017381(transcript)|ensembl:ENSRNOT00000086878(transcript)|go:"GO:0001671"(ATPase activator activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051085"(chaperone cofactor-dependent protein refolding)|go:"GO:0051087"(chaperone binding)|interpro:IPR001623(Heat shock protein DnaJ, N-terminal)|interpro:IPR002939(Chaperone DnaJ, C-terminal)	-	-	-	caution:"The participant EBI-349571(P68370) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919386(Q7TP47) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920972(Q5XIP9) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-916419(P11980) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919578(Q8R491) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920554(Q5U3Z7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920647(Q5U2X8) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920585(Q7TP24) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-779677(P05426) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-915744(P02454) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|agonist:Insulin was shown to increase or decrease GLUT4 protein interactions in specific cases.|comment:"Insulin decreased GLUT4 interactions with the following proteins: Q9ER30 (Sarcosin), P09527 (Rab-7), O88960 (N-ethylmaleimide sensitive), P09456 (PKA I regulatory subunit), P27881 (Hexokinase type II), P07872 (Acyl-coenzyme A oxidase), Q6DGF1 (Isocitrate dehydrogenase), Q9EQX9 (Ubiquitin-conjugating), Q63446 (Polyubiquitin), P24268 (Cathepsin D), Q91XW0 (Heat shock protein 86), Q5FVH0 (unknown), P58405 (Striatin 3), Q62667 (Major vault protein), Q66H50 (unknown), Q09167 (splicing factor), Q9JHU5 (Arfaptin 1)."|comment:"Insulin increased GLUT4 interaction with the following proteins:Q9Z1P2 (R-actinin-1), P45592 (Cofilin), Q9QXQ0 (R-actinin-4), P26473 (ADP-ribosylation factor), P26437 (ADP-ribosylation factor),   Q7TNP1 (Basigin 2), Q6P6R2 (Dihydrolipoamide dehydrogenase),   P04797 (GAPDH), Q63081 (Protein disulfide isomerase), P29457 (47 kDa heat shock protein), Q9R1J8 (Leprecan), O88638 (Putative eps protein),   Q64375 (Synaptonemal complex)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:NDPK - Interactions involving proteins containing InterPro domain IPR001564, Nucleoside diphosphate kinase, core.	taxid:10116(rat-l6)|taxid:10116(Rattus norvegicus)	-	2006/02/15	2021/11/30	rogid:PbFY2lfrty8yw40Jq7ShR7xfuV410116	rogid:mvXSDlVog9Y+VG/Cb+t6EPzzmMM10116	intact-crc:44F3A2176D02515F|rigid:9RVm0UBcqQF4k06RGKO89Bg16Q8	false	myc tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P19357	uniprotkb:Q5XIP9	intact:EBI-915426|uniprotkb:P97900|ensembl:ENSRNOP00000023256	intact:EBI-920972|ensembl:ENSRNOP00000010895	psi-mi:glut4_rat(display_long)|uniprotkb:Glucose transporter type 4, insulin-responsive(gene name synonym)|uniprotkb:Slc2a4(gene name)|psi-mi:Slc2a4(display_short)|uniprotkb:Glut4(gene name synonym)	psi-mi:tmm43_rat(display_long)|uniprotkb:Tmem43(gene name)|psi-mi:Tmem43(display_short)|uniprotkb:Protein LUMA(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Foster et al. (2006)	pubmed:16396496|mint:MINT-5218203	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-921030	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2711|refseq:NP_036883.1|refseq:XP_006246658.1|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007611"(learning or memory)|go:"GO:0007614"(short-term memory)|go:"GO:0007616"(long-term memory)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010021"(amylopectin biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031550"(positive regulation of brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044381"(glucose import in response to insulin stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046323"(glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0098694"(regulation of synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0098793"(presynapse)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002441("Glucose transporter, type 4 (GLUT4)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-189200|ensembl:ENSRNOG00000017226(gene)|ensembl:ENSRNOT00000023256(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)	rgd:1549711|refseq:NP_001007746.1|go:"GO:0005637"(nuclear inner membrane)|go:"GO:0005639"(integral component of nuclear inner membrane)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0042802"(identical protein binding)|go:"GO:0043621"(protein self-association)|go:"GO:0071763"(nuclear membrane organization)|interpro:IPR012430(Protein of unknown function DUF1625)|ensembl:ENSRNOG00000007519(gene)|ensembl:ENSRNOT00000010895(transcript)	-	-	-	caution:"The participant EBI-349571(P68370) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919386(Q7TP47) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920972(Q5XIP9) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-916419(P11980) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919578(Q8R491) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920554(Q5U3Z7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920647(Q5U2X8) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920585(Q7TP24) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-779677(P05426) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-915744(P02454) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|agonist:Insulin was shown to increase or decrease GLUT4 protein interactions in specific cases.|comment:"Insulin decreased GLUT4 interactions with the following proteins: Q9ER30 (Sarcosin), P09527 (Rab-7), O88960 (N-ethylmaleimide sensitive), P09456 (PKA I regulatory subunit), P27881 (Hexokinase type II), P07872 (Acyl-coenzyme A oxidase), Q6DGF1 (Isocitrate dehydrogenase), Q9EQX9 (Ubiquitin-conjugating), Q63446 (Polyubiquitin), P24268 (Cathepsin D), Q91XW0 (Heat shock protein 86), Q5FVH0 (unknown), P58405 (Striatin 3), Q62667 (Major vault protein), Q66H50 (unknown), Q09167 (splicing factor), Q9JHU5 (Arfaptin 1)."|comment:"Insulin increased GLUT4 interaction with the following proteins:Q9Z1P2 (R-actinin-1), P45592 (Cofilin), Q9QXQ0 (R-actinin-4), P26473 (ADP-ribosylation factor), P26437 (ADP-ribosylation factor),   Q7TNP1 (Basigin 2), Q6P6R2 (Dihydrolipoamide dehydrogenase),   P04797 (GAPDH), Q63081 (Protein disulfide isomerase), P29457 (47 kDa heat shock protein), Q9R1J8 (Leprecan), O88638 (Putative eps protein),   Q64375 (Synaptonemal complex)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:NDPK - Interactions involving proteins containing InterPro domain IPR001564, Nucleoside diphosphate kinase, core.	taxid:10116(rat-l6)|taxid:10116(Rattus norvegicus)	-	2006/02/15	2021/11/30	rogid:PbFY2lfrty8yw40Jq7ShR7xfuV410116	rogid:GUW1fF6GsnHx31R3kF9vptuFjjc10116	intact-crc:44F3A2176D02515F|rigid:9RVm0UBcqQF4k06RGKO89Bg16Q8	false	myc tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P19357	uniprotkb:Q5M7W1	intact:EBI-915426|uniprotkb:P97900|ensembl:ENSRNOP00000023256	intact:EBI-920966|ensembl:ENSRNOP00000028793	psi-mi:glut4_rat(display_long)|uniprotkb:Glucose transporter type 4, insulin-responsive(gene name synonym)|uniprotkb:Slc2a4(gene name)|psi-mi:Slc2a4(display_short)|uniprotkb:Glut4(gene name synonym)	psi-mi:txnip_rat(display_long)|uniprotkb:Txnip(gene name)|psi-mi:Txnip(display_short)|uniprotkb:Vitamin D3 up-regulated protein 1(gene name synonym)|uniprotkb:Vdup1(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Foster et al. (2006)	pubmed:16396496|mint:MINT-5218203	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-921030	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2711|refseq:NP_036883.1|refseq:XP_006246658.1|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007611"(learning or memory)|go:"GO:0007614"(short-term memory)|go:"GO:0007616"(long-term memory)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010021"(amylopectin biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031550"(positive regulation of brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044381"(glucose import in response to insulin stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046323"(glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0098694"(regulation of synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0098793"(presynapse)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002441("Glucose transporter, type 4 (GLUT4)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-189200|ensembl:ENSRNOG00000017226(gene)|ensembl:ENSRNOT00000023256(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)	rgd:620886|refseq:NP_001008767.1|go:"GO:0032570"(response to progesterone)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042493"|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0048008"(platelet-derived growth factor receptor signaling pathway)|go:"GO:0051592"(response to calcium ion)|go:"GO:0051782"(negative regulation of cell division)|go:"GO:0071228"(cellular response to tumor cell)|interpro:IPR011021(Arrestin-like, N-terminal)|interpro:IPR011022(Arrestin-like, C-terminal)|interpro:IPR014752(Arrestin, C-terminal)|interpro:IPR014756(Immunoglobulin E-set)|reactome:R-RNO-844456|ensembl:ENSRNOG00000021201(gene)|ensembl:ENSRNOT00000028793(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0004857"(enzyme inhibitor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0007049"(cell cycle)|go:"GO:0009612"(response to mechanical stimulus)|go:"GO:0009749"(response to glucose)|go:"GO:0015031"(protein transport)|go:"GO:0030216"(keratinocyte differentiation)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032355"(response to estradiol)	-	-	-	caution:"The participant EBI-349571(P68370) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919386(Q7TP47) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920972(Q5XIP9) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-916419(P11980) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919578(Q8R491) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920554(Q5U3Z7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920647(Q5U2X8) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920585(Q7TP24) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-779677(P05426) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-915744(P02454) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|agonist:Insulin was shown to increase or decrease GLUT4 protein interactions in specific cases.|comment:"Insulin decreased GLUT4 interactions with the following proteins: Q9ER30 (Sarcosin), P09527 (Rab-7), O88960 (N-ethylmaleimide sensitive), P09456 (PKA I regulatory subunit), P27881 (Hexokinase type II), P07872 (Acyl-coenzyme A oxidase), Q6DGF1 (Isocitrate dehydrogenase), Q9EQX9 (Ubiquitin-conjugating), Q63446 (Polyubiquitin), P24268 (Cathepsin D), Q91XW0 (Heat shock protein 86), Q5FVH0 (unknown), P58405 (Striatin 3), Q62667 (Major vault protein), Q66H50 (unknown), Q09167 (splicing factor), Q9JHU5 (Arfaptin 1)."|comment:"Insulin increased GLUT4 interaction with the following proteins:Q9Z1P2 (R-actinin-1), P45592 (Cofilin), Q9QXQ0 (R-actinin-4), P26473 (ADP-ribosylation factor), P26437 (ADP-ribosylation factor),   Q7TNP1 (Basigin 2), Q6P6R2 (Dihydrolipoamide dehydrogenase),   P04797 (GAPDH), Q63081 (Protein disulfide isomerase), P29457 (47 kDa heat shock protein), Q9R1J8 (Leprecan), O88638 (Putative eps protein),   Q64375 (Synaptonemal complex)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:NDPK - Interactions involving proteins containing InterPro domain IPR001564, Nucleoside diphosphate kinase, core.	taxid:10116(rat-l6)|taxid:10116(Rattus norvegicus)	-	2006/02/15	2021/11/30	rogid:PbFY2lfrty8yw40Jq7ShR7xfuV410116	rogid:C9EN4EB0HQU8eubsd207xhwmL2010116	intact-crc:44F3A2176D02515F|rigid:9RVm0UBcqQF4k06RGKO89Bg16Q8	false	myc tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P19357	uniprotkb:Q5XIU9	intact:EBI-915426|uniprotkb:P97900|ensembl:ENSRNOP00000023256	intact:EBI-920960|ensembl:ENSRNOP00000018796	psi-mi:glut4_rat(display_long)|uniprotkb:Glucose transporter type 4, insulin-responsive(gene name synonym)|uniprotkb:Slc2a4(gene name)|psi-mi:Slc2a4(display_short)|uniprotkb:Glut4(gene name synonym)	psi-mi:pgrc2_rat(display_long)|uniprotkb:Pgrmc2(gene name)|psi-mi:Pgrmc2(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Foster et al. (2006)	pubmed:16396496|mint:MINT-5218203	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-921030	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2711|refseq:NP_036883.1|refseq:XP_006246658.1|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007611"(learning or memory)|go:"GO:0007614"(short-term memory)|go:"GO:0007616"(long-term memory)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010021"(amylopectin biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031550"(positive regulation of brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044381"(glucose import in response to insulin stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046323"(glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0098694"(regulation of synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0098793"(presynapse)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002441("Glucose transporter, type 4 (GLUT4)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-189200|ensembl:ENSRNOG00000017226(gene)|ensembl:ENSRNOT00000023256(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)	rgd:1308804|refseq:NP_001008375.1|ensembl:ENSRNOG00000014051(gene)|ensembl:ENSRNOT00000018796(transcript)|go:"GO:0005496"(steroid binding)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0012505"(endomembrane system)|go:"GO:0015232"(heme transmembrane transporter activity)|go:"GO:0015886"(heme transport)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0020037"(heme binding)|go:"GO:0060612"(adipose tissue development)|interpro:IPR001199(Cytochrome b5)|interpro:IPR036400|reactome:R-RNO-8980692|reactome:R-RNO-9013404|reactome:R-RNO-9013405|reactome:R-RNO-9013408|reactome:R-RNO-9013423	-	-	-	caution:"The participant EBI-349571(P68370) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919386(Q7TP47) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920972(Q5XIP9) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-916419(P11980) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919578(Q8R491) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920554(Q5U3Z7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920647(Q5U2X8) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920585(Q7TP24) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-779677(P05426) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-915744(P02454) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|agonist:Insulin was shown to increase or decrease GLUT4 protein interactions in specific cases.|comment:"Insulin decreased GLUT4 interactions with the following proteins: Q9ER30 (Sarcosin), P09527 (Rab-7), O88960 (N-ethylmaleimide sensitive), P09456 (PKA I regulatory subunit), P27881 (Hexokinase type II), P07872 (Acyl-coenzyme A oxidase), Q6DGF1 (Isocitrate dehydrogenase), Q9EQX9 (Ubiquitin-conjugating), Q63446 (Polyubiquitin), P24268 (Cathepsin D), Q91XW0 (Heat shock protein 86), Q5FVH0 (unknown), P58405 (Striatin 3), Q62667 (Major vault protein), Q66H50 (unknown), Q09167 (splicing factor), Q9JHU5 (Arfaptin 1)."|comment:"Insulin increased GLUT4 interaction with the following proteins:Q9Z1P2 (R-actinin-1), P45592 (Cofilin), Q9QXQ0 (R-actinin-4), P26473 (ADP-ribosylation factor), P26437 (ADP-ribosylation factor),   Q7TNP1 (Basigin 2), Q6P6R2 (Dihydrolipoamide dehydrogenase),   P04797 (GAPDH), Q63081 (Protein disulfide isomerase), P29457 (47 kDa heat shock protein), Q9R1J8 (Leprecan), O88638 (Putative eps protein),   Q64375 (Synaptonemal complex)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:NDPK - Interactions involving proteins containing InterPro domain IPR001564, Nucleoside diphosphate kinase, core.	taxid:10116(rat-l6)|taxid:10116(Rattus norvegicus)	-	2006/02/15	2021/11/30	rogid:PbFY2lfrty8yw40Jq7ShR7xfuV410116	rogid:3QSqH5b91N9GwE4ixZi6BSTyy1U10116	intact-crc:44F3A2176D02515F|rigid:9RVm0UBcqQF4k06RGKO89Bg16Q8	false	myc tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P19357	uniprotkb:Q5XIT9	intact:EBI-915426|uniprotkb:P97900|ensembl:ENSRNOP00000023256	intact:EBI-920952|ensembl:ENSRNOP00000023900	psi-mi:glut4_rat(display_long)|uniprotkb:Glucose transporter type 4, insulin-responsive(gene name synonym)|uniprotkb:Slc2a4(gene name)|psi-mi:Slc2a4(display_short)|uniprotkb:Glut4(gene name synonym)	psi-mi:mccb_rat(display_long)|uniprotkb:Mccc2(gene name)|psi-mi:Mccc2(display_short)|uniprotkb:"3-methylcrotonyl-CoA:carbon dioxide ligase subunit beta"(gene name synonym)|uniprotkb:3-methylcrotonyl-CoA carboxylase non-biotin-containing subunit(gene name synonym)|uniprotkb:3-methylcrotonyl-CoA carboxylase 2(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Foster et al. (2006)	pubmed:16396496|mint:MINT-5218203	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-921030	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2711|refseq:NP_036883.1|refseq:XP_006246658.1|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007611"(learning or memory)|go:"GO:0007614"(short-term memory)|go:"GO:0007616"(long-term memory)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010021"(amylopectin biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031550"(positive regulation of brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044381"(glucose import in response to insulin stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046323"(glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0098694"(regulation of synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0098793"(presynapse)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002441("Glucose transporter, type 4 (GLUT4)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-189200|ensembl:ENSRNOG00000017226(gene)|ensembl:ENSRNOT00000023256(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)	rgd:1310279|refseq:NP_001012177.1|ensembl:ENSRNOG00000017752(gene)|ensembl:ENSRNOT00000023900(transcript)|go:"GO:0004485"(methylcrotonoyl-CoA carboxylase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0006552"(leucine catabolic process)|go:"GO:0015936"(coenzyme A metabolic process)|go:"GO:1905202"(methylcrotonoyl-CoA carboxylase complex)|interpro:IPR011762(Acetyl-coenzyme A carboxyltransferase, N-terminal)|interpro:IPR011763(Acetyl-coenzyme A carboxyltransferase, C-terminal)|interpro:IPR029045|interpro:IPR034733|reactome:R-RNO-196780|reactome:R-RNO-70895	-	-	-	caution:"The participant EBI-349571(P68370) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919386(Q7TP47) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920972(Q5XIP9) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-916419(P11980) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919578(Q8R491) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920554(Q5U3Z7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920647(Q5U2X8) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920585(Q7TP24) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-779677(P05426) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-915744(P02454) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|agonist:Insulin was shown to increase or decrease GLUT4 protein interactions in specific cases.|comment:"Insulin decreased GLUT4 interactions with the following proteins: Q9ER30 (Sarcosin), P09527 (Rab-7), O88960 (N-ethylmaleimide sensitive), P09456 (PKA I regulatory subunit), P27881 (Hexokinase type II), P07872 (Acyl-coenzyme A oxidase), Q6DGF1 (Isocitrate dehydrogenase), Q9EQX9 (Ubiquitin-conjugating), Q63446 (Polyubiquitin), P24268 (Cathepsin D), Q91XW0 (Heat shock protein 86), Q5FVH0 (unknown), P58405 (Striatin 3), Q62667 (Major vault protein), Q66H50 (unknown), Q09167 (splicing factor), Q9JHU5 (Arfaptin 1)."|comment:"Insulin increased GLUT4 interaction with the following proteins:Q9Z1P2 (R-actinin-1), P45592 (Cofilin), Q9QXQ0 (R-actinin-4), P26473 (ADP-ribosylation factor), P26437 (ADP-ribosylation factor),   Q7TNP1 (Basigin 2), Q6P6R2 (Dihydrolipoamide dehydrogenase),   P04797 (GAPDH), Q63081 (Protein disulfide isomerase), P29457 (47 kDa heat shock protein), Q9R1J8 (Leprecan), O88638 (Putative eps protein),   Q64375 (Synaptonemal complex)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:NDPK - Interactions involving proteins containing InterPro domain IPR001564, Nucleoside diphosphate kinase, core.	taxid:10116(rat-l6)|taxid:10116(Rattus norvegicus)	-	2006/02/15	2021/11/30	rogid:PbFY2lfrty8yw40Jq7ShR7xfuV410116	rogid:GnhRDbZ18hqoktGwduGsUT9P7gw10116	intact-crc:44F3A2176D02515F|rigid:9RVm0UBcqQF4k06RGKO89Bg16Q8	false	myc tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P19357	uniprotkb:P56574	intact:EBI-915426|uniprotkb:P97900|ensembl:ENSRNOP00000023256	intact:EBI-920942|uniprotkb:Q6DGF1|ensembl:ENSRNOP00000019059	psi-mi:glut4_rat(display_long)|uniprotkb:Glucose transporter type 4, insulin-responsive(gene name synonym)|uniprotkb:Slc2a4(gene name)|psi-mi:Slc2a4(display_short)|uniprotkb:Glut4(gene name synonym)	psi-mi:idhp_rat(display_long)|uniprotkb:Idh2(gene name)|psi-mi:Idh2(display_short)|uniprotkb:Oxalosuccinate decarboxylase(gene name synonym)|uniprotkb:"NADP(+)-specific ICDH"(gene name synonym)|uniprotkb:IDP(gene name synonym)|uniprotkb:ICD-M(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Foster et al. (2006)	pubmed:16396496|mint:MINT-5218203	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-921030	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2711|refseq:NP_036883.1|refseq:XP_006246658.1|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007611"(learning or memory)|go:"GO:0007614"(short-term memory)|go:"GO:0007616"(long-term memory)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010021"(amylopectin biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031550"(positive regulation of brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044381"(glucose import in response to insulin stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046323"(glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0098694"(regulation of synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0098793"(presynapse)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002441("Glucose transporter, type 4 (GLUT4)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-189200|ensembl:ENSRNOG00000017226(gene)|ensembl:ENSRNOT00000023256(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)	rgd:1597139|refseq:NP_001014183.1|ensembl:ENSRNOG00000013949(gene)|ensembl:ENSRNOT00000019059(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0004448"(isocitrate dehydrogenase activity)|go:"GO:0004450"("isocitrate dehydrogenase (NADP+) activity")|go:"GO:0005739"(mitochondrion)|go:"GO:0005777"(peroxisome)|go:"GO:0005829"(cytosol)|go:"GO:0006097"(glyoxylate cycle)|go:"GO:0006099"(tricarboxylic acid cycle)|go:"GO:0006102"(isocitrate metabolic process)|go:"GO:0006103"(2-oxoglutarate metabolic process)|go:"GO:0006739"(NADP metabolic process)|go:"GO:0006741"(NADP biosynthetic process)|go:"GO:0051287"(NAD binding)|go:"GO:0060253"(negative regulation of glial cell proliferation)|go:"GO:1903976"(negative regulation of glial cell migration)|go:"GO:1904465"(negative regulation of matrix metallopeptidase secretion)|interpro:IPR004790(Isocitrate dehydrogenase NADP-dependent, eukaryotic)|interpro:IPR019818|interpro:IPR024084|mint:P56574|reactome:R-RNO-2151201|reactome:R-RNO-71403	-	-	-	caution:"The participant EBI-349571(P68370) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919386(Q7TP47) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920972(Q5XIP9) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-916419(P11980) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919578(Q8R491) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920554(Q5U3Z7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920647(Q5U2X8) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920585(Q7TP24) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-779677(P05426) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-915744(P02454) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|agonist:Insulin was shown to increase or decrease GLUT4 protein interactions in specific cases.|comment:"Insulin decreased GLUT4 interactions with the following proteins: Q9ER30 (Sarcosin), P09527 (Rab-7), O88960 (N-ethylmaleimide sensitive), P09456 (PKA I regulatory subunit), P27881 (Hexokinase type II), P07872 (Acyl-coenzyme A oxidase), Q6DGF1 (Isocitrate dehydrogenase), Q9EQX9 (Ubiquitin-conjugating), Q63446 (Polyubiquitin), P24268 (Cathepsin D), Q91XW0 (Heat shock protein 86), Q5FVH0 (unknown), P58405 (Striatin 3), Q62667 (Major vault protein), Q66H50 (unknown), Q09167 (splicing factor), Q9JHU5 (Arfaptin 1)."|comment:"Insulin increased GLUT4 interaction with the following proteins:Q9Z1P2 (R-actinin-1), P45592 (Cofilin), Q9QXQ0 (R-actinin-4), P26473 (ADP-ribosylation factor), P26437 (ADP-ribosylation factor),   Q7TNP1 (Basigin 2), Q6P6R2 (Dihydrolipoamide dehydrogenase),   P04797 (GAPDH), Q63081 (Protein disulfide isomerase), P29457 (47 kDa heat shock protein), Q9R1J8 (Leprecan), O88638 (Putative eps protein),   Q64375 (Synaptonemal complex)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:NDPK - Interactions involving proteins containing InterPro domain IPR001564, Nucleoside diphosphate kinase, core.	taxid:10116(rat-l6)|taxid:10116(Rattus norvegicus)	-	2006/02/15	2021/11/30	rogid:PbFY2lfrty8yw40Jq7ShR7xfuV410116	rogid:CGI/bMOGAnNsRs5goqGEWMPqPp010116	intact-crc:44F3A2176D02515F|rigid:9RVm0UBcqQF4k06RGKO89Bg16Q8	false	myc tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P19357	uniprotkb:Q3T1L0	intact:EBI-915426|uniprotkb:P97900|ensembl:ENSRNOP00000023256	intact:EBI-920934|ensembl:ENSRNOP00000027992	psi-mi:glut4_rat(display_long)|uniprotkb:Glucose transporter type 4, insulin-responsive(gene name synonym)|uniprotkb:Slc2a4(gene name)|psi-mi:Slc2a4(display_short)|uniprotkb:Glut4(gene name synonym)	psi-mi:a16a1_rat(display_long)|uniprotkb:Aldh16a1(gene name)|psi-mi:Aldh16a1(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Foster et al. (2006)	pubmed:16396496|mint:MINT-5218203	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-921030	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2711|refseq:NP_036883.1|refseq:XP_006246658.1|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007611"(learning or memory)|go:"GO:0007614"(short-term memory)|go:"GO:0007616"(long-term memory)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010021"(amylopectin biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031550"(positive regulation of brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044381"(glucose import in response to insulin stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046323"(glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0098694"(regulation of synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0098793"(presynapse)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002441("Glucose transporter, type 4 (GLUT4)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-189200|ensembl:ENSRNOG00000017226(gene)|ensembl:ENSRNOT00000023256(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)	rgd:1566295|refseq:NP_001028878.1|ensembl:ENSRNOG00000020623(gene)|ensembl:ENSRNOT00000027992(transcript)|go:"GO:0016620"(oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor)|interpro:IPR011408(Aldehyde dehydrogenase predicted, duplicated region)|interpro:IPR015590(Aldehyde dehydrogenase)|interpro:IPR016161(Aldehyde/histidinol dehydrogenase)|interpro:IPR016162(Aldehyde dehydrogenase, N-terminal)|interpro:IPR016163(Aldehyde dehydrogenase, C-terminal)	-	-	-	caution:"The participant EBI-349571(P68370) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919386(Q7TP47) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920972(Q5XIP9) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-916419(P11980) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919578(Q8R491) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920554(Q5U3Z7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920647(Q5U2X8) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920585(Q7TP24) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-779677(P05426) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-915744(P02454) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|agonist:Insulin was shown to increase or decrease GLUT4 protein interactions in specific cases.|comment:"Insulin decreased GLUT4 interactions with the following proteins: Q9ER30 (Sarcosin), P09527 (Rab-7), O88960 (N-ethylmaleimide sensitive), P09456 (PKA I regulatory subunit), P27881 (Hexokinase type II), P07872 (Acyl-coenzyme A oxidase), Q6DGF1 (Isocitrate dehydrogenase), Q9EQX9 (Ubiquitin-conjugating), Q63446 (Polyubiquitin), P24268 (Cathepsin D), Q91XW0 (Heat shock protein 86), Q5FVH0 (unknown), P58405 (Striatin 3), Q62667 (Major vault protein), Q66H50 (unknown), Q09167 (splicing factor), Q9JHU5 (Arfaptin 1)."|comment:"Insulin increased GLUT4 interaction with the following proteins:Q9Z1P2 (R-actinin-1), P45592 (Cofilin), Q9QXQ0 (R-actinin-4), P26473 (ADP-ribosylation factor), P26437 (ADP-ribosylation factor),   Q7TNP1 (Basigin 2), Q6P6R2 (Dihydrolipoamide dehydrogenase),   P04797 (GAPDH), Q63081 (Protein disulfide isomerase), P29457 (47 kDa heat shock protein), Q9R1J8 (Leprecan), O88638 (Putative eps protein),   Q64375 (Synaptonemal complex)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:NDPK - Interactions involving proteins containing InterPro domain IPR001564, Nucleoside diphosphate kinase, core.	taxid:10116(rat-l6)|taxid:10116(Rattus norvegicus)	-	2006/02/15	2021/11/30	rogid:PbFY2lfrty8yw40Jq7ShR7xfuV410116	rogid:lED44lBhJ/rLuGpXYDZvQ81H0JU10116	intact-crc:44F3A2176D02515F|rigid:9RVm0UBcqQF4k06RGKO89Bg16Q8	false	myc tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P19357	uniprotkb:Q5FVH2	intact:EBI-915426|uniprotkb:P97900|ensembl:ENSRNOP00000023256	intact:EBI-920925|ensembl:ENSRNOP00000054004	psi-mi:glut4_rat(display_long)|uniprotkb:Glucose transporter type 4, insulin-responsive(gene name synonym)|uniprotkb:Slc2a4(gene name)|psi-mi:Slc2a4(display_short)|uniprotkb:Glut4(gene name synonym)	psi-mi:pld3_rat(display_long)|uniprotkb:Pld3(gene name)|psi-mi:Pld3(display_short)|uniprotkb:Choline phosphatase 3(gene name synonym)|uniprotkb:Phosphatidylcholine-hydrolyzing phospholipase D3(gene name synonym)|uniprotkb:Phospholipase D3(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Foster et al. (2006)	pubmed:16396496|mint:MINT-5218203	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-921030	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2711|refseq:NP_036883.1|refseq:XP_006246658.1|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007611"(learning or memory)|go:"GO:0007614"(short-term memory)|go:"GO:0007616"(long-term memory)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010021"(amylopectin biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031550"(positive regulation of brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044381"(glucose import in response to insulin stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046323"(glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0098694"(regulation of synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0098793"(presynapse)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002441("Glucose transporter, type 4 (GLUT4)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-189200|ensembl:ENSRNOG00000017226(gene)|ensembl:ENSRNOT00000023256(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)	rgd:1308248|refseq:NP_001012167.1|refseq:XP_006228640.1|refseq:XP_006228641.1|refseq:XP_006228642.1|refseq:XP_006228643.1|ensembl:ENSRNOG00000018390(gene)|ensembl:ENSRNOT00000057177(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0002376"(immune system process)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0014902"(myotube differentiation)|go:"GO:0016021"(integral component of membrane)|go:"GO:0031901"(early endosome membrane)|go:"GO:0031902"(late endosome membrane)|go:"GO:0043202"(lysosomal lumen)|go:"GO:0045145"(single-stranded DNA 5'-3' exodeoxyribonuclease activity)|go:"GO:1900015"(regulation of cytokine production involved in inflammatory response)|interpro:IPR001736(Phospholipase D/Transphosphatidylase)|interpro:IPR032803|reactome:R-RNO-2029485	-	-	-	caution:"The participant EBI-349571(P68370) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919386(Q7TP47) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920972(Q5XIP9) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-916419(P11980) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919578(Q8R491) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920554(Q5U3Z7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920647(Q5U2X8) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920585(Q7TP24) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-779677(P05426) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-915744(P02454) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|agonist:Insulin was shown to increase or decrease GLUT4 protein interactions in specific cases.|comment:"Insulin decreased GLUT4 interactions with the following proteins: Q9ER30 (Sarcosin), P09527 (Rab-7), O88960 (N-ethylmaleimide sensitive), P09456 (PKA I regulatory subunit), P27881 (Hexokinase type II), P07872 (Acyl-coenzyme A oxidase), Q6DGF1 (Isocitrate dehydrogenase), Q9EQX9 (Ubiquitin-conjugating), Q63446 (Polyubiquitin), P24268 (Cathepsin D), Q91XW0 (Heat shock protein 86), Q5FVH0 (unknown), P58405 (Striatin 3), Q62667 (Major vault protein), Q66H50 (unknown), Q09167 (splicing factor), Q9JHU5 (Arfaptin 1)."|comment:"Insulin increased GLUT4 interaction with the following proteins:Q9Z1P2 (R-actinin-1), P45592 (Cofilin), Q9QXQ0 (R-actinin-4), P26473 (ADP-ribosylation factor), P26437 (ADP-ribosylation factor),   Q7TNP1 (Basigin 2), Q6P6R2 (Dihydrolipoamide dehydrogenase),   P04797 (GAPDH), Q63081 (Protein disulfide isomerase), P29457 (47 kDa heat shock protein), Q9R1J8 (Leprecan), O88638 (Putative eps protein),   Q64375 (Synaptonemal complex)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:NDPK - Interactions involving proteins containing InterPro domain IPR001564, Nucleoside diphosphate kinase, core.	taxid:10116(rat-l6)|taxid:10116(Rattus norvegicus)	-	2006/02/15	2021/11/30	rogid:PbFY2lfrty8yw40Jq7ShR7xfuV410116	rogid:BSuvqspSkRTSATGvkXaTH+jyh3k10116	intact-crc:44F3A2176D02515F|rigid:9RVm0UBcqQF4k06RGKO89Bg16Q8	false	myc tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P19357	uniprotkb:Q4V8B7	intact:EBI-915426|uniprotkb:P97900|ensembl:ENSRNOP00000023256	intact:EBI-920916|ensembl:ENSRNOP00000020860	psi-mi:glut4_rat(display_long)|uniprotkb:Glucose transporter type 4, insulin-responsive(gene name synonym)|uniprotkb:Slc2a4(gene name)|psi-mi:Slc2a4(display_short)|uniprotkb:Glut4(gene name synonym)	psi-mi:hsdl1_rat(display_long)|uniprotkb:Hsdl1(gene name)|psi-mi:Hsdl1(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Foster et al. (2006)	pubmed:16396496|mint:MINT-5218203	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-921030	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2711|refseq:NP_036883.1|refseq:XP_006246658.1|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007611"(learning or memory)|go:"GO:0007614"(short-term memory)|go:"GO:0007616"(long-term memory)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010021"(amylopectin biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031550"(positive regulation of brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044381"(glucose import in response to insulin stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046323"(glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0098694"(regulation of synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0098793"(presynapse)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002441("Glucose transporter, type 4 (GLUT4)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-189200|ensembl:ENSRNOG00000017226(gene)|ensembl:ENSRNOT00000023256(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)	rgd:1308433|refseq:NP_001020067.1|refseq:XP_006255775.1|refseq:XP_006255776.1|ensembl:ENSRNOG00000015576(gene)|ensembl:ENSRNOT00000020859(transcript)|go:"GO:0005739"(mitochondrion)|go:"GO:0016491"(oxidoreductase activity)|go:"GO:0045111"(intermediate filament cytoskeleton)|interpro:IPR002347(Glucose/ribitol dehydrogenase)|interpro:IPR036291	-	-	-	caution:"The participant EBI-349571(P68370) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919386(Q7TP47) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920972(Q5XIP9) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-916419(P11980) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919578(Q8R491) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920554(Q5U3Z7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920647(Q5U2X8) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920585(Q7TP24) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-779677(P05426) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-915744(P02454) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|agonist:Insulin was shown to increase or decrease GLUT4 protein interactions in specific cases.|comment:"Insulin decreased GLUT4 interactions with the following proteins: Q9ER30 (Sarcosin), P09527 (Rab-7), O88960 (N-ethylmaleimide sensitive), P09456 (PKA I regulatory subunit), P27881 (Hexokinase type II), P07872 (Acyl-coenzyme A oxidase), Q6DGF1 (Isocitrate dehydrogenase), Q9EQX9 (Ubiquitin-conjugating), Q63446 (Polyubiquitin), P24268 (Cathepsin D), Q91XW0 (Heat shock protein 86), Q5FVH0 (unknown), P58405 (Striatin 3), Q62667 (Major vault protein), Q66H50 (unknown), Q09167 (splicing factor), Q9JHU5 (Arfaptin 1)."|comment:"Insulin increased GLUT4 interaction with the following proteins:Q9Z1P2 (R-actinin-1), P45592 (Cofilin), Q9QXQ0 (R-actinin-4), P26473 (ADP-ribosylation factor), P26437 (ADP-ribosylation factor),   Q7TNP1 (Basigin 2), Q6P6R2 (Dihydrolipoamide dehydrogenase),   P04797 (GAPDH), Q63081 (Protein disulfide isomerase), P29457 (47 kDa heat shock protein), Q9R1J8 (Leprecan), O88638 (Putative eps protein),   Q64375 (Synaptonemal complex)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:NDPK - Interactions involving proteins containing InterPro domain IPR001564, Nucleoside diphosphate kinase, core.	taxid:10116(rat-l6)|taxid:10116(Rattus norvegicus)	-	2006/02/15	2021/11/30	rogid:PbFY2lfrty8yw40Jq7ShR7xfuV410116	rogid:ecKY0sPwzWZR+eY6t2v4xVBjzRU10116	intact-crc:44F3A2176D02515F|rigid:9RVm0UBcqQF4k06RGKO89Bg16Q8	false	myc tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P19357	uniprotkb:Q68FS9	intact:EBI-915426|uniprotkb:P97900|ensembl:ENSRNOP00000023256	intact:EBI-920911|ensembl:ENSRNOP00000005260	psi-mi:glut4_rat(display_long)|uniprotkb:Glucose transporter type 4, insulin-responsive(gene name synonym)|uniprotkb:Slc2a4(gene name)|psi-mi:Slc2a4(display_short)|uniprotkb:Glut4(gene name synonym)	psi-mi:q68fs9_rat(display_long)|uniprotkb:Commd10(gene name)|psi-mi:Commd10(display_short)|uniprotkb:rCG_46658(orf name)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Foster et al. (2006)	pubmed:16396496|mint:MINT-5218203	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-921030	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2711|refseq:NP_036883.1|refseq:XP_006246658.1|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007611"(learning or memory)|go:"GO:0007614"(short-term memory)|go:"GO:0007616"(long-term memory)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010021"(amylopectin biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031550"(positive regulation of brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044381"(glucose import in response to insulin stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046323"(glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0098694"(regulation of synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0098793"(presynapse)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002441("Glucose transporter, type 4 (GLUT4)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-189200|ensembl:ENSRNOG00000017226(gene)|ensembl:ENSRNOT00000023256(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)	rgd:1303015|refseq:NP_001004276.1|ensembl:ENSRNOG00000003958(gene)|ensembl:ENSRNOT00000005260(transcript)|go:"GO:0005654"(nucleoplasm)|interpro:IPR017920|interpro:IPR037361|reactome:R-RNO-8951664	-	-	-	caution:"The participant EBI-349571(P68370) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919386(Q7TP47) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920972(Q5XIP9) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-916419(P11980) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919578(Q8R491) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920554(Q5U3Z7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920647(Q5U2X8) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920585(Q7TP24) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-779677(P05426) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-915744(P02454) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|agonist:Insulin was shown to increase or decrease GLUT4 protein interactions in specific cases.|comment:"Insulin decreased GLUT4 interactions with the following proteins: Q9ER30 (Sarcosin), P09527 (Rab-7), O88960 (N-ethylmaleimide sensitive), P09456 (PKA I regulatory subunit), P27881 (Hexokinase type II), P07872 (Acyl-coenzyme A oxidase), Q6DGF1 (Isocitrate dehydrogenase), Q9EQX9 (Ubiquitin-conjugating), Q63446 (Polyubiquitin), P24268 (Cathepsin D), Q91XW0 (Heat shock protein 86), Q5FVH0 (unknown), P58405 (Striatin 3), Q62667 (Major vault protein), Q66H50 (unknown), Q09167 (splicing factor), Q9JHU5 (Arfaptin 1)."|comment:"Insulin increased GLUT4 interaction with the following proteins:Q9Z1P2 (R-actinin-1), P45592 (Cofilin), Q9QXQ0 (R-actinin-4), P26473 (ADP-ribosylation factor), P26437 (ADP-ribosylation factor),   Q7TNP1 (Basigin 2), Q6P6R2 (Dihydrolipoamide dehydrogenase),   P04797 (GAPDH), Q63081 (Protein disulfide isomerase), P29457 (47 kDa heat shock protein), Q9R1J8 (Leprecan), O88638 (Putative eps protein),   Q64375 (Synaptonemal complex)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:NDPK - Interactions involving proteins containing InterPro domain IPR001564, Nucleoside diphosphate kinase, core.	taxid:10116(rat-l6)|taxid:10116(Rattus norvegicus)	-	2006/02/15	2021/11/30	rogid:PbFY2lfrty8yw40Jq7ShR7xfuV410116	rogid:U5Mj1TyzDftxEFSN7ks+WDycXsQ10116	intact-crc:44F3A2176D02515F|rigid:9RVm0UBcqQF4k06RGKO89Bg16Q8	false	myc tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P19357	uniprotkb:D3ZJR1	intact:EBI-915426|uniprotkb:P97900|ensembl:ENSRNOP00000023256	intact:EBI-920895|ensembl:ENSRNOP00000018960|intact:EBI-6095240|uniprotkb:Q4QQT7	psi-mi:glut4_rat(display_long)|uniprotkb:Glucose transporter type 4, insulin-responsive(gene name synonym)|uniprotkb:Slc2a4(gene name)|psi-mi:Slc2a4(display_short)|uniprotkb:Glut4(gene name synonym)	psi-mi:d3zjr1_rat(display_long)|uniprotkb:Eps15l1(gene name)|psi-mi:Eps15l1(display_short)|uniprotkb:LOC361120(gene name synonym)|uniprotkb:rCG_38753(orf name)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Foster et al. (2006)	pubmed:16396496|mint:MINT-5218203	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-921030	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2711|refseq:NP_036883.1|refseq:XP_006246658.1|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007611"(learning or memory)|go:"GO:0007614"(short-term memory)|go:"GO:0007616"(long-term memory)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010021"(amylopectin biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031550"(positive regulation of brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044381"(glucose import in response to insulin stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046323"(glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0098694"(regulation of synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0098793"(presynapse)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002441("Glucose transporter, type 4 (GLUT4)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-189200|ensembl:ENSRNOG00000017226(gene)|ensembl:ENSRNOT00000023256(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)	rgd:1565708|refseq:XP_006252866.1|interpro:IPR011992(EF-Hand type)|interpro:IPR018247|reactome:R-RNO-182971|reactome:R-RNO-8856825|reactome:R-RNO-8856828|ensembl:ENSRNOG00000013502(gene)|ensembl:ENSRNOT00000018960(transcript)|go:"GO:0005509"(calcium ion binding)|go:"GO:0006897"(endocytosis)|go:"GO:0016197"(endosomal transport)|go:"GO:0030132"(clathrin coat of coated pit)|interpro:IPR000261("EPS15 homology (EH)")|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR003903(Ubiquitin interacting motif)	-	-	-	caution:"The participant EBI-349571(P68370) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919386(Q7TP47) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920972(Q5XIP9) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-916419(P11980) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919578(Q8R491) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920554(Q5U3Z7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920647(Q5U2X8) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920585(Q7TP24) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-779677(P05426) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-915744(P02454) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|agonist:Insulin was shown to increase or decrease GLUT4 protein interactions in specific cases.|comment:"Insulin decreased GLUT4 interactions with the following proteins: Q9ER30 (Sarcosin), P09527 (Rab-7), O88960 (N-ethylmaleimide sensitive), P09456 (PKA I regulatory subunit), P27881 (Hexokinase type II), P07872 (Acyl-coenzyme A oxidase), Q6DGF1 (Isocitrate dehydrogenase), Q9EQX9 (Ubiquitin-conjugating), Q63446 (Polyubiquitin), P24268 (Cathepsin D), Q91XW0 (Heat shock protein 86), Q5FVH0 (unknown), P58405 (Striatin 3), Q62667 (Major vault protein), Q66H50 (unknown), Q09167 (splicing factor), Q9JHU5 (Arfaptin 1)."|comment:"Insulin increased GLUT4 interaction with the following proteins:Q9Z1P2 (R-actinin-1), P45592 (Cofilin), Q9QXQ0 (R-actinin-4), P26473 (ADP-ribosylation factor), P26437 (ADP-ribosylation factor),   Q7TNP1 (Basigin 2), Q6P6R2 (Dihydrolipoamide dehydrogenase),   P04797 (GAPDH), Q63081 (Protein disulfide isomerase), P29457 (47 kDa heat shock protein), Q9R1J8 (Leprecan), O88638 (Putative eps protein),   Q64375 (Synaptonemal complex)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:NDPK - Interactions involving proteins containing InterPro domain IPR001564, Nucleoside diphosphate kinase, core.	taxid:10116(rat-l6)|taxid:10116(Rattus norvegicus)	-	2006/02/15	2021/11/30	rogid:PbFY2lfrty8yw40Jq7ShR7xfuV410116	rogid:buZjZQnEeJz7EstZTTyYJQ/09p810116	intact-crc:44F3A2176D02515F|rigid:9RVm0UBcqQF4k06RGKO89Bg16Q8	false	myc tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P19357	uniprotkb:Q5EBA4	intact:EBI-915426|uniprotkb:P97900|ensembl:ENSRNOP00000023256	intact:EBI-920890	psi-mi:glut4_rat(display_long)|uniprotkb:Glucose transporter type 4, insulin-responsive(gene name synonym)|uniprotkb:Slc2a4(gene name)|psi-mi:Slc2a4(display_short)|uniprotkb:Glut4(gene name synonym)	psi-mi:q5eba4_rat(display_long)|uniprotkb:Nipsnap1(gene name)|psi-mi:Nipsnap1(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Foster et al. (2006)	pubmed:16396496|mint:MINT-5218203	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-921030	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2711|refseq:NP_036883.1|refseq:XP_006246658.1|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007611"(learning or memory)|go:"GO:0007614"(short-term memory)|go:"GO:0007616"(long-term memory)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010021"(amylopectin biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031550"(positive regulation of brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044381"(glucose import in response to insulin stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046323"(glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0098694"(regulation of synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0098793"(presynapse)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002441("Glucose transporter, type 4 (GLUT4)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-189200|ensembl:ENSRNOG00000017226(gene)|ensembl:ENSRNOT00000023256(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)	rgd:1310419|refseq:NP_001094200.1|interpro:IPR011008(Dimeric alpha-beta barrel)|interpro:IPR012577(NIPSNAP)|go:"GO:0005739"(mitochondrion)|go:"GO:0016020"(membrane)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0042165"(neurotransmitter binding)|go:"GO:0097060"(synaptic membrane)	-	-	-	caution:"The participant EBI-349571(P68370) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919386(Q7TP47) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920972(Q5XIP9) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-916419(P11980) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919578(Q8R491) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920554(Q5U3Z7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920647(Q5U2X8) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920585(Q7TP24) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-779677(P05426) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-915744(P02454) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|agonist:Insulin was shown to increase or decrease GLUT4 protein interactions in specific cases.|comment:"Insulin decreased GLUT4 interactions with the following proteins: Q9ER30 (Sarcosin), P09527 (Rab-7), O88960 (N-ethylmaleimide sensitive), P09456 (PKA I regulatory subunit), P27881 (Hexokinase type II), P07872 (Acyl-coenzyme A oxidase), Q6DGF1 (Isocitrate dehydrogenase), Q9EQX9 (Ubiquitin-conjugating), Q63446 (Polyubiquitin), P24268 (Cathepsin D), Q91XW0 (Heat shock protein 86), Q5FVH0 (unknown), P58405 (Striatin 3), Q62667 (Major vault protein), Q66H50 (unknown), Q09167 (splicing factor), Q9JHU5 (Arfaptin 1)."|comment:"Insulin increased GLUT4 interaction with the following proteins:Q9Z1P2 (R-actinin-1), P45592 (Cofilin), Q9QXQ0 (R-actinin-4), P26473 (ADP-ribosylation factor), P26437 (ADP-ribosylation factor),   Q7TNP1 (Basigin 2), Q6P6R2 (Dihydrolipoamide dehydrogenase),   P04797 (GAPDH), Q63081 (Protein disulfide isomerase), P29457 (47 kDa heat shock protein), Q9R1J8 (Leprecan), O88638 (Putative eps protein),   Q64375 (Synaptonemal complex)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:NDPK - Interactions involving proteins containing InterPro domain IPR001564, Nucleoside diphosphate kinase, core.	taxid:10116(rat-l6)|taxid:10116(Rattus norvegicus)	-	2006/02/15	2021/11/30	rogid:PbFY2lfrty8yw40Jq7ShR7xfuV410116	rogid:WY8zNT9UMAwSr8UcxP1Y1VB7VMo10116	intact-crc:44F3A2176D02515F|rigid:9RVm0UBcqQF4k06RGKO89Bg16Q8	false	myc tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P19357	uniprotkb:Q68FW4	intact:EBI-915426|uniprotkb:P97900|ensembl:ENSRNOP00000023256	intact:EBI-920884|ensembl:ENSRNOP00000008410	psi-mi:glut4_rat(display_long)|uniprotkb:Glucose transporter type 4, insulin-responsive(gene name synonym)|uniprotkb:Slc2a4(gene name)|psi-mi:Slc2a4(display_short)|uniprotkb:Glut4(gene name synonym)	psi-mi:stx18_rat(display_long)|uniprotkb:Stx18(gene name)|psi-mi:Stx18(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Foster et al. (2006)	pubmed:16396496|mint:MINT-5218203	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-921030	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2711|refseq:NP_036883.1|refseq:XP_006246658.1|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007611"(learning or memory)|go:"GO:0007614"(short-term memory)|go:"GO:0007616"(long-term memory)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010021"(amylopectin biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031550"(positive regulation of brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044381"(glucose import in response to insulin stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046323"(glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0098694"(regulation of synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0098793"(presynapse)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002441("Glucose transporter, type 4 (GLUT4)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-189200|ensembl:ENSRNOG00000017226(gene)|ensembl:ENSRNOT00000023256(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)	rgd:1310058|refseq:NP_001012151.1|ensembl:ENSRNOG00000006139(gene)|go:"GO:0000139"(Golgi membrane)|go:"GO:0005484"(SNAP receptor activity)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006890"(retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0031201"(SNARE complex)|go:"GO:0090158"(endoplasmic reticulum membrane organization)|go:"GO:1902117"(positive regulation of organelle assembly)|go:"GO:1902953"(positive regulation of ER to Golgi vesicle-mediated transport)|go:"GO:1903358"(regulation of Golgi organization)|interpro:IPR006012(Syntaxin/epimorphin, conserved site)|interpro:IPR019529|reactome:R-RNO-6811434|ensembl:ENSRNOT00000008410(transcript)	-	-	-	caution:"The participant EBI-349571(P68370) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919386(Q7TP47) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920972(Q5XIP9) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-916419(P11980) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919578(Q8R491) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920554(Q5U3Z7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920647(Q5U2X8) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920585(Q7TP24) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-779677(P05426) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-915744(P02454) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|agonist:Insulin was shown to increase or decrease GLUT4 protein interactions in specific cases.|comment:"Insulin decreased GLUT4 interactions with the following proteins: Q9ER30 (Sarcosin), P09527 (Rab-7), O88960 (N-ethylmaleimide sensitive), P09456 (PKA I regulatory subunit), P27881 (Hexokinase type II), P07872 (Acyl-coenzyme A oxidase), Q6DGF1 (Isocitrate dehydrogenase), Q9EQX9 (Ubiquitin-conjugating), Q63446 (Polyubiquitin), P24268 (Cathepsin D), Q91XW0 (Heat shock protein 86), Q5FVH0 (unknown), P58405 (Striatin 3), Q62667 (Major vault protein), Q66H50 (unknown), Q09167 (splicing factor), Q9JHU5 (Arfaptin 1)."|comment:"Insulin increased GLUT4 interaction with the following proteins:Q9Z1P2 (R-actinin-1), P45592 (Cofilin), Q9QXQ0 (R-actinin-4), P26473 (ADP-ribosylation factor), P26437 (ADP-ribosylation factor),   Q7TNP1 (Basigin 2), Q6P6R2 (Dihydrolipoamide dehydrogenase),   P04797 (GAPDH), Q63081 (Protein disulfide isomerase), P29457 (47 kDa heat shock protein), Q9R1J8 (Leprecan), O88638 (Putative eps protein),   Q64375 (Synaptonemal complex)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:NDPK - Interactions involving proteins containing InterPro domain IPR001564, Nucleoside diphosphate kinase, core.	taxid:10116(rat-l6)|taxid:10116(Rattus norvegicus)	-	2006/02/15	2021/11/30	rogid:PbFY2lfrty8yw40Jq7ShR7xfuV410116	rogid:WyiCLeyYq/Q14LcoukVdeXWninM10116	intact-crc:44F3A2176D02515F|rigid:9RVm0UBcqQF4k06RGKO89Bg16Q8	false	myc tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P19357	uniprotkb:Q5XI73	intact:EBI-915426|uniprotkb:P97900|ensembl:ENSRNOP00000023256	intact:EBI-920877|ensembl:ENSRNOP00000051840	psi-mi:glut4_rat(display_long)|uniprotkb:Glucose transporter type 4, insulin-responsive(gene name synonym)|uniprotkb:Slc2a4(gene name)|psi-mi:Slc2a4(display_short)|uniprotkb:Glut4(gene name synonym)	psi-mi:gdir1_rat(display_long)|uniprotkb:Arhgdia(gene name)|psi-mi:Arhgdia(display_short)|uniprotkb:Rho-GDI alpha(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Foster et al. (2006)	pubmed:16396496|mint:MINT-5218203	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-921030	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2711|refseq:NP_036883.1|refseq:XP_006246658.1|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007611"(learning or memory)|go:"GO:0007614"(short-term memory)|go:"GO:0007616"(long-term memory)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010021"(amylopectin biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031550"(positive regulation of brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044381"(glucose import in response to insulin stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046323"(glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0098694"(regulation of synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0098793"(presynapse)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002441("Glucose transporter, type 4 (GLUT4)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-189200|ensembl:ENSRNOG00000017226(gene)|ensembl:ENSRNOT00000023256(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)	rgd:1359547|refseq:NP_001007006.1|refseq:XP_006247959.1|refseq:XP_006247960.1|ensembl:ENSRNOG00000036688(gene)|ensembl:ENSRNOT00000054957(transcript)|go:"GO:0001772"(immunological synapse)|go:"GO:0005094"(Rho GDP-dissociation inhibitor activity)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005504"(fatty acid binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0007266"(Rho protein signal transduction)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0016020"(membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0031267"(small GTPase binding)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0035023"(regulation of Rho protein signal transduction)|go:"GO:0045202"(synapse)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0071461"(cellular response to redox state)|go:"GO:0071526"(semaphorin-plexin signaling pathway)|go:"GO:2000249"(regulation of actin cytoskeleton reorganization)|interpro:IPR000406(RHO protein GDP dissociation inhibitor)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR024792|reactome:R-RNO-193634|reactome:R-RNO-209563|reactome:R-RNO-8980692|reactome:R-RNO-9013106|reactome:R-RNO-9013148|reactome:R-RNO-9013149|reactome:R-RNO-9013404|reactome:R-RNO-9013407|reactome:R-RNO-9013408	-	-	-	caution:"The participant EBI-349571(P68370) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919386(Q7TP47) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920972(Q5XIP9) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-916419(P11980) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919578(Q8R491) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920554(Q5U3Z7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920647(Q5U2X8) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920585(Q7TP24) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-779677(P05426) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-915744(P02454) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|agonist:Insulin was shown to increase or decrease GLUT4 protein interactions in specific cases.|comment:"Insulin decreased GLUT4 interactions with the following proteins: Q9ER30 (Sarcosin), P09527 (Rab-7), O88960 (N-ethylmaleimide sensitive), P09456 (PKA I regulatory subunit), P27881 (Hexokinase type II), P07872 (Acyl-coenzyme A oxidase), Q6DGF1 (Isocitrate dehydrogenase), Q9EQX9 (Ubiquitin-conjugating), Q63446 (Polyubiquitin), P24268 (Cathepsin D), Q91XW0 (Heat shock protein 86), Q5FVH0 (unknown), P58405 (Striatin 3), Q62667 (Major vault protein), Q66H50 (unknown), Q09167 (splicing factor), Q9JHU5 (Arfaptin 1)."|comment:"Insulin increased GLUT4 interaction with the following proteins:Q9Z1P2 (R-actinin-1), P45592 (Cofilin), Q9QXQ0 (R-actinin-4), P26473 (ADP-ribosylation factor), P26437 (ADP-ribosylation factor),   Q7TNP1 (Basigin 2), Q6P6R2 (Dihydrolipoamide dehydrogenase),   P04797 (GAPDH), Q63081 (Protein disulfide isomerase), P29457 (47 kDa heat shock protein), Q9R1J8 (Leprecan), O88638 (Putative eps protein),   Q64375 (Synaptonemal complex)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:NDPK - Interactions involving proteins containing InterPro domain IPR001564, Nucleoside diphosphate kinase, core.	taxid:10116(rat-l6)|taxid:10116(Rattus norvegicus)	-	2006/02/15	2021/11/30	rogid:PbFY2lfrty8yw40Jq7ShR7xfuV410116	rogid:T543bldr5c9EXiP1DXLnG6GuTsc10116	intact-crc:44F3A2176D02515F|rigid:9RVm0UBcqQF4k06RGKO89Bg16Q8	false	myc tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P19357	uniprotkb:Q6AY55	intact:EBI-915426|uniprotkb:P97900|ensembl:ENSRNOP00000023256	intact:EBI-920865|ensembl:ENSRNOP00000037891|ensembl:ENSRNOP00000074921	psi-mi:glut4_rat(display_long)|uniprotkb:Glucose transporter type 4, insulin-responsive(gene name synonym)|uniprotkb:Slc2a4(gene name)|psi-mi:Slc2a4(display_short)|uniprotkb:Glut4(gene name synonym)	psi-mi:dcakd_rat(display_long)|uniprotkb:Dcakd(gene name)|psi-mi:Dcakd(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Foster et al. (2006)	pubmed:16396496|mint:MINT-5218203	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-921030	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2711|refseq:NP_036883.1|refseq:XP_006246658.1|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007611"(learning or memory)|go:"GO:0007614"(short-term memory)|go:"GO:0007616"(long-term memory)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010021"(amylopectin biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031550"(positive regulation of brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044381"(glucose import in response to insulin stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046323"(glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0098694"(regulation of synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0098793"(presynapse)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002441("Glucose transporter, type 4 (GLUT4)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-189200|ensembl:ENSRNOG00000017226(gene)|ensembl:ENSRNOT00000023256(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)	refseq:XP_008766515.1|rgd:1359211|refseq:NP_001007725.1|refseq:XP_006247594.1|go:"GO:0015937"(coenzyme A biosynthetic process)|interpro:IPR001977(Dephospho-CoA kinase)|interpro:IPR027417|ensembl:ENSRNOG00000021682(gene)|ensembl:ENSRNOT00000031498(transcript)|ensembl:ENSRNOT00000080077(transcript)|go:"GO:0004140"(dephospho-CoA kinase activity)|go:"GO:0005524"(ATP binding)|refseq:XP_017452895.1	-	-	-	caution:"The participant EBI-349571(P68370) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919386(Q7TP47) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920972(Q5XIP9) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-916419(P11980) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919578(Q8R491) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920554(Q5U3Z7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920647(Q5U2X8) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920585(Q7TP24) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-779677(P05426) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-915744(P02454) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|agonist:Insulin was shown to increase or decrease GLUT4 protein interactions in specific cases.|comment:"Insulin decreased GLUT4 interactions with the following proteins: Q9ER30 (Sarcosin), P09527 (Rab-7), O88960 (N-ethylmaleimide sensitive), P09456 (PKA I regulatory subunit), P27881 (Hexokinase type II), P07872 (Acyl-coenzyme A oxidase), Q6DGF1 (Isocitrate dehydrogenase), Q9EQX9 (Ubiquitin-conjugating), Q63446 (Polyubiquitin), P24268 (Cathepsin D), Q91XW0 (Heat shock protein 86), Q5FVH0 (unknown), P58405 (Striatin 3), Q62667 (Major vault protein), Q66H50 (unknown), Q09167 (splicing factor), Q9JHU5 (Arfaptin 1)."|comment:"Insulin increased GLUT4 interaction with the following proteins:Q9Z1P2 (R-actinin-1), P45592 (Cofilin), Q9QXQ0 (R-actinin-4), P26473 (ADP-ribosylation factor), P26437 (ADP-ribosylation factor),   Q7TNP1 (Basigin 2), Q6P6R2 (Dihydrolipoamide dehydrogenase),   P04797 (GAPDH), Q63081 (Protein disulfide isomerase), P29457 (47 kDa heat shock protein), Q9R1J8 (Leprecan), O88638 (Putative eps protein),   Q64375 (Synaptonemal complex)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:NDPK - Interactions involving proteins containing InterPro domain IPR001564, Nucleoside diphosphate kinase, core.	taxid:10116(rat-l6)|taxid:10116(Rattus norvegicus)	-	2006/02/15	2021/11/30	rogid:PbFY2lfrty8yw40Jq7ShR7xfuV410116	rogid:eL7FnLECpR7mK0k6g0zpsyDYPHM10116	intact-crc:44F3A2176D02515F|rigid:9RVm0UBcqQF4k06RGKO89Bg16Q8	false	myc tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P19357	uniprotkb:Q5U1Y1	intact:EBI-915426|uniprotkb:P97900|ensembl:ENSRNOP00000023256	intact:EBI-920850	psi-mi:glut4_rat(display_long)|uniprotkb:Glucose transporter type 4, insulin-responsive(gene name synonym)|uniprotkb:Slc2a4(gene name)|psi-mi:Slc2a4(display_short)|uniprotkb:Glut4(gene name synonym)	psi-mi:rab34_rat(display_long)|uniprotkb:Rab34(gene name)|psi-mi:Rab34(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Foster et al. (2006)	pubmed:16396496|mint:MINT-5218203	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-921030	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2711|refseq:NP_036883.1|refseq:XP_006246658.1|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007611"(learning or memory)|go:"GO:0007614"(short-term memory)|go:"GO:0007616"(long-term memory)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010021"(amylopectin biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031550"(positive regulation of brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044381"(glucose import in response to insulin stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046323"(glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0098694"(regulation of synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0098793"(presynapse)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002441("Glucose transporter, type 4 (GLUT4)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-189200|ensembl:ENSRNOG00000017226(gene)|ensembl:ENSRNOT00000023256(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)	refseq:NP_001012140.1|rgd:1305058|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR001806(Ras GTPase)|go:"GO:0005770"(late endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005795"(Golgi stack)|go:"GO:0005929"(cilium)|go:"GO:0006897"(endocytosis)|go:"GO:0007041"(lysosomal transport)|go:"GO:0019001"(guanyl nucleotide binding)|go:"GO:0019882"(antigen processing and presentation)|go:"GO:0030030"(cell projection organization)|go:"GO:0030670"(phagocytic vesicle membrane)|go:"GO:0030742"(GTP-dependent protein binding)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031982"(vesicle)|go:"GO:0031985"(Golgi cisterna)|go:"GO:0032418"(lysosome localization)|go:"GO:0043001"(Golgi to plasma membrane protein transport)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0045880"(positive regulation of smoothened signaling pathway)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050714"(positive regulation of protein secretion)|go:"GO:0071333"(cellular response to glucose stimulus)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0090382"(phagosome maturation)|go:"GO:0090385"(phagosome-lysosome fusion)|go:"GO:1900426"(positive regulation of defense response to bacterium)|go:"GO:1905171"(positive regulation of protein localization to phagocytic vesicle)|interpro:IPR027417|go:"GO:0001726"(ruffle)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005769"(early endosome)|reactome:R-RNO-8873719	-	-	-	caution:"The participant EBI-349571(P68370) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919386(Q7TP47) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920972(Q5XIP9) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-916419(P11980) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919578(Q8R491) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920554(Q5U3Z7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920647(Q5U2X8) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920585(Q7TP24) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-779677(P05426) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-915744(P02454) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|agonist:Insulin was shown to increase or decrease GLUT4 protein interactions in specific cases.|comment:"Insulin decreased GLUT4 interactions with the following proteins: Q9ER30 (Sarcosin), P09527 (Rab-7), O88960 (N-ethylmaleimide sensitive), P09456 (PKA I regulatory subunit), P27881 (Hexokinase type II), P07872 (Acyl-coenzyme A oxidase), Q6DGF1 (Isocitrate dehydrogenase), Q9EQX9 (Ubiquitin-conjugating), Q63446 (Polyubiquitin), P24268 (Cathepsin D), Q91XW0 (Heat shock protein 86), Q5FVH0 (unknown), P58405 (Striatin 3), Q62667 (Major vault protein), Q66H50 (unknown), Q09167 (splicing factor), Q9JHU5 (Arfaptin 1)."|comment:"Insulin increased GLUT4 interaction with the following proteins:Q9Z1P2 (R-actinin-1), P45592 (Cofilin), Q9QXQ0 (R-actinin-4), P26473 (ADP-ribosylation factor), P26437 (ADP-ribosylation factor),   Q7TNP1 (Basigin 2), Q6P6R2 (Dihydrolipoamide dehydrogenase),   P04797 (GAPDH), Q63081 (Protein disulfide isomerase), P29457 (47 kDa heat shock protein), Q9R1J8 (Leprecan), O88638 (Putative eps protein),   Q64375 (Synaptonemal complex)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:NDPK - Interactions involving proteins containing InterPro domain IPR001564, Nucleoside diphosphate kinase, core.	taxid:10116(rat-l6)|taxid:10116(Rattus norvegicus)	-	2006/02/15	2021/11/30	rogid:PbFY2lfrty8yw40Jq7ShR7xfuV410116	rogid:0PaFs7Hj9ruA4dqm5lIw4/vdFns10116	intact-crc:44F3A2176D02515F|rigid:9RVm0UBcqQF4k06RGKO89Bg16Q8	false	myc tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P19357	uniprotkb:Q3KR97	intact:EBI-915426|uniprotkb:P97900|ensembl:ENSRNOP00000023256	intact:EBI-920845|uniprotkb:Q5FWT2|ensembl:ENSRNOP00000057568	psi-mi:glut4_rat(display_long)|uniprotkb:Glucose transporter type 4, insulin-responsive(gene name synonym)|uniprotkb:Slc2a4(gene name)|psi-mi:Slc2a4(display_short)|uniprotkb:Glut4(gene name synonym)	psi-mi:bi2l1_rat(display_long)|uniprotkb:Baiap2l1(gene name)|psi-mi:Baiap2l1(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Foster et al. (2006)	pubmed:16396496|mint:MINT-5218203	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-921030	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2711|refseq:NP_036883.1|refseq:XP_006246658.1|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007611"(learning or memory)|go:"GO:0007614"(short-term memory)|go:"GO:0007616"(long-term memory)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010021"(amylopectin biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031550"(positive regulation of brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044381"(glucose import in response to insulin stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046323"(glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0098694"(regulation of synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0098793"(presynapse)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002441("Glucose transporter, type 4 (GLUT4)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-189200|ensembl:ENSRNOG00000017226(gene)|ensembl:ENSRNOT00000023256(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)	rgd:1308452|refseq:NP_001029312.1|interpro:IPR030060|interpro:IPR035592|interpro:IPR036028|reactome:R-RNO-9013149|reactome:R-RNO-9013404|reactome:R-RNO-9013423|reactome:R-RNO-9035034|ensembl:ENSRNOG00000001007(gene)|ensembl:ENSRNOT00000060843(transcript)|go:"GO:0003779"(actin binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007009"(plasma membrane organization)|go:"GO:0009617"(response to bacterium)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0046626"(regulation of insulin receptor signaling pathway)|go:"GO:0051017"(actin filament bundle assembly)|go:"GO:0051764"(actin crosslink formation)|go:"GO:0070064"(proline-rich region binding)|go:"GO:2000251"(positive regulation of actin cytoskeleton reorganization)|interpro:IPR001452(Src homology-3)|interpro:IPR013606("IRSp53/MIM homology domain (IMD)")|interpro:IPR027267|interpro:IPR027681	-	-	-	caution:"The participant EBI-349571(P68370) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919386(Q7TP47) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920972(Q5XIP9) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-916419(P11980) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919578(Q8R491) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920554(Q5U3Z7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920647(Q5U2X8) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920585(Q7TP24) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-779677(P05426) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-915744(P02454) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|agonist:Insulin was shown to increase or decrease GLUT4 protein interactions in specific cases.|comment:"Insulin decreased GLUT4 interactions with the following proteins: Q9ER30 (Sarcosin), P09527 (Rab-7), O88960 (N-ethylmaleimide sensitive), P09456 (PKA I regulatory subunit), P27881 (Hexokinase type II), P07872 (Acyl-coenzyme A oxidase), Q6DGF1 (Isocitrate dehydrogenase), Q9EQX9 (Ubiquitin-conjugating), Q63446 (Polyubiquitin), P24268 (Cathepsin D), Q91XW0 (Heat shock protein 86), Q5FVH0 (unknown), P58405 (Striatin 3), Q62667 (Major vault protein), Q66H50 (unknown), Q09167 (splicing factor), Q9JHU5 (Arfaptin 1)."|comment:"Insulin increased GLUT4 interaction with the following proteins:Q9Z1P2 (R-actinin-1), P45592 (Cofilin), Q9QXQ0 (R-actinin-4), P26473 (ADP-ribosylation factor), P26437 (ADP-ribosylation factor),   Q7TNP1 (Basigin 2), Q6P6R2 (Dihydrolipoamide dehydrogenase),   P04797 (GAPDH), Q63081 (Protein disulfide isomerase), P29457 (47 kDa heat shock protein), Q9R1J8 (Leprecan), O88638 (Putative eps protein),   Q64375 (Synaptonemal complex)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:NDPK - Interactions involving proteins containing InterPro domain IPR001564, Nucleoside diphosphate kinase, core.	taxid:10116(rat-l6)|taxid:10116(Rattus norvegicus)	-	2006/02/15	2021/11/30	rogid:PbFY2lfrty8yw40Jq7ShR7xfuV410116	rogid:el1NcYd8RfEL2+CC1M/77w2BMq810116	intact-crc:44F3A2176D02515F|rigid:9RVm0UBcqQF4k06RGKO89Bg16Q8	false	myc tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P19357	uniprotkb:Q4V8B5	intact:EBI-915426|uniprotkb:P97900|ensembl:ENSRNOP00000023256	intact:EBI-920841|ensembl:ENSRNOP00000040746	psi-mi:glut4_rat(display_long)|uniprotkb:Glucose transporter type 4, insulin-responsive(gene name synonym)|uniprotkb:Slc2a4(gene name)|psi-mi:Slc2a4(display_short)|uniprotkb:Glut4(gene name synonym)	psi-mi:cc116_rat(display_long)|uniprotkb:Ccdc116(gene name)|psi-mi:Ccdc116(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Foster et al. (2006)	pubmed:16396496|mint:MINT-5218203	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-921030	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2711|refseq:NP_036883.1|refseq:XP_006246658.1|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007611"(learning or memory)|go:"GO:0007614"(short-term memory)|go:"GO:0007616"(long-term memory)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010021"(amylopectin biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031550"(positive regulation of brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044381"(glucose import in response to insulin stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046323"(glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0098694"(regulation of synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0098793"(presynapse)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002441("Glucose transporter, type 4 (GLUT4)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-189200|ensembl:ENSRNOG00000017226(gene)|ensembl:ENSRNOT00000023256(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)	rgd:1310080|refseq:NP_001019911.1|refseq:XP_006248738.1|ensembl:ENSRNOG00000001860(gene)|ensembl:ENSRNOT00000041557(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|interpro:IPR031532	-	-	-	caution:"The participant EBI-349571(P68370) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919386(Q7TP47) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920972(Q5XIP9) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-916419(P11980) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919578(Q8R491) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920554(Q5U3Z7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920647(Q5U2X8) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920585(Q7TP24) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-779677(P05426) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-915744(P02454) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|agonist:Insulin was shown to increase or decrease GLUT4 protein interactions in specific cases.|comment:"Insulin decreased GLUT4 interactions with the following proteins: Q9ER30 (Sarcosin), P09527 (Rab-7), O88960 (N-ethylmaleimide sensitive), P09456 (PKA I regulatory subunit), P27881 (Hexokinase type II), P07872 (Acyl-coenzyme A oxidase), Q6DGF1 (Isocitrate dehydrogenase), Q9EQX9 (Ubiquitin-conjugating), Q63446 (Polyubiquitin), P24268 (Cathepsin D), Q91XW0 (Heat shock protein 86), Q5FVH0 (unknown), P58405 (Striatin 3), Q62667 (Major vault protein), Q66H50 (unknown), Q09167 (splicing factor), Q9JHU5 (Arfaptin 1)."|comment:"Insulin increased GLUT4 interaction with the following proteins:Q9Z1P2 (R-actinin-1), P45592 (Cofilin), Q9QXQ0 (R-actinin-4), P26473 (ADP-ribosylation factor), P26437 (ADP-ribosylation factor),   Q7TNP1 (Basigin 2), Q6P6R2 (Dihydrolipoamide dehydrogenase),   P04797 (GAPDH), Q63081 (Protein disulfide isomerase), P29457 (47 kDa heat shock protein), Q9R1J8 (Leprecan), O88638 (Putative eps protein),   Q64375 (Synaptonemal complex)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:NDPK - Interactions involving proteins containing InterPro domain IPR001564, Nucleoside diphosphate kinase, core.	taxid:10116(rat-l6)|taxid:10116(Rattus norvegicus)	-	2006/02/15	2021/11/30	rogid:PbFY2lfrty8yw40Jq7ShR7xfuV410116	rogid:Uk9/fFPqHXJIJXiljI4rT+Hjsdo10116	intact-crc:44F3A2176D02515F|rigid:9RVm0UBcqQF4k06RGKO89Bg16Q8	false	myc tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P19357	uniprotkb:Q66H98	intact:EBI-915426|uniprotkb:P97900|ensembl:ENSRNOP00000023256	intact:EBI-920837|ensembl:ENSRNOP00000030025	psi-mi:glut4_rat(display_long)|uniprotkb:Glucose transporter type 4, insulin-responsive(gene name synonym)|uniprotkb:Slc2a4(gene name)|psi-mi:Slc2a4(display_short)|uniprotkb:Glut4(gene name synonym)	psi-mi:cavn2_rat(display_long)|uniprotkb:Cavin2(gene name)|psi-mi:Cavin2(display_short)|uniprotkb:Cavin-2(gene name synonym)|uniprotkb:Phosphatidylserine-binding protein(gene name synonym)|uniprotkb:Sdpr(gene name synonym)|uniprotkb:Serum deprivation-response protein(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Foster et al. (2006)	pubmed:16396496|mint:MINT-5218203	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-921030	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2711|refseq:NP_036883.1|refseq:XP_006246658.1|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007611"(learning or memory)|go:"GO:0007614"(short-term memory)|go:"GO:0007616"(long-term memory)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010021"(amylopectin biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031550"(positive regulation of brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044381"(glucose import in response to insulin stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046323"(glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0098694"(regulation of synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0098793"(presynapse)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002441("Glucose transporter, type 4 (GLUT4)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-189200|ensembl:ENSRNOG00000017226(gene)|ensembl:ENSRNOT00000023256(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)	rgd:1359345|refseq:NP_001007713.1|ensembl:ENSRNOG00000025895(gene)|ensembl:ENSRNOT00000028907(transcript)|go:"GO:0001786"(phosphatidylserine binding)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005901"(caveola)|go:"GO:0045121"(membrane raft)|go:"GO:0097320"(plasma membrane tubulation)|interpro:IPR026752|interpro:IPR033298	-	-	-	caution:"The participant EBI-349571(P68370) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919386(Q7TP47) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920972(Q5XIP9) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-916419(P11980) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919578(Q8R491) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920554(Q5U3Z7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920647(Q5U2X8) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920585(Q7TP24) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-779677(P05426) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-915744(P02454) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|agonist:Insulin was shown to increase or decrease GLUT4 protein interactions in specific cases.|comment:"Insulin decreased GLUT4 interactions with the following proteins: Q9ER30 (Sarcosin), P09527 (Rab-7), O88960 (N-ethylmaleimide sensitive), P09456 (PKA I regulatory subunit), P27881 (Hexokinase type II), P07872 (Acyl-coenzyme A oxidase), Q6DGF1 (Isocitrate dehydrogenase), Q9EQX9 (Ubiquitin-conjugating), Q63446 (Polyubiquitin), P24268 (Cathepsin D), Q91XW0 (Heat shock protein 86), Q5FVH0 (unknown), P58405 (Striatin 3), Q62667 (Major vault protein), Q66H50 (unknown), Q09167 (splicing factor), Q9JHU5 (Arfaptin 1)."|comment:"Insulin increased GLUT4 interaction with the following proteins:Q9Z1P2 (R-actinin-1), P45592 (Cofilin), Q9QXQ0 (R-actinin-4), P26473 (ADP-ribosylation factor), P26437 (ADP-ribosylation factor),   Q7TNP1 (Basigin 2), Q6P6R2 (Dihydrolipoamide dehydrogenase),   P04797 (GAPDH), Q63081 (Protein disulfide isomerase), P29457 (47 kDa heat shock protein), Q9R1J8 (Leprecan), O88638 (Putative eps protein),   Q64375 (Synaptonemal complex)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:NDPK - Interactions involving proteins containing InterPro domain IPR001564, Nucleoside diphosphate kinase, core.	taxid:10116(rat-l6)|taxid:10116(Rattus norvegicus)	-	2006/02/15	2021/11/30	rogid:PbFY2lfrty8yw40Jq7ShR7xfuV410116	rogid:Q+TtDjS+mLyLuOj2mt15ok1RcPo10116	intact-crc:44F3A2176D02515F|rigid:9RVm0UBcqQF4k06RGKO89Bg16Q8	false	myc tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P19357	uniprotkb:Q5BJX1	intact:EBI-915426|uniprotkb:P97900|ensembl:ENSRNOP00000023256	intact:EBI-920832|ensembl:ENSRNOP00000042070	psi-mi:glut4_rat(display_long)|uniprotkb:Glucose transporter type 4, insulin-responsive(gene name synonym)|uniprotkb:Slc2a4(gene name)|psi-mi:Slc2a4(display_short)|uniprotkb:Glut4(gene name synonym)	psi-mi:rm41_rat(display_long)|uniprotkb:Mrpl41(gene name)|psi-mi:Mrpl41(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Foster et al. (2006)	pubmed:16396496|mint:MINT-5218203	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-921030	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2711|refseq:NP_036883.1|refseq:XP_006246658.1|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007611"(learning or memory)|go:"GO:0007614"(short-term memory)|go:"GO:0007616"(long-term memory)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010021"(amylopectin biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031550"(positive regulation of brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044381"(glucose import in response to insulin stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046323"(glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0098694"(regulation of synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0098793"(presynapse)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002441("Glucose transporter, type 4 (GLUT4)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-189200|ensembl:ENSRNOG00000017226(gene)|ensembl:ENSRNOT00000023256(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)	rgd:1310241|refseq:NP_001013444.1|ensembl:ENSRNOG00000029875(gene)|ensembl:ENSRNOT00000044802(transcript)|go:"GO:0003735"(structural constituent of ribosome)|go:"GO:0005762"(mitochondrial large ribosomal subunit)|go:"GO:0006412"(translation)|go:"GO:0006915"(apoptotic process)|go:"GO:0007049"(cell cycle)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR019189|reactome:R-RNO-5389840|reactome:R-RNO-5419276	-	-	-	caution:"The participant EBI-349571(P68370) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919386(Q7TP47) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920972(Q5XIP9) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-916419(P11980) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919578(Q8R491) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920554(Q5U3Z7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920647(Q5U2X8) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920585(Q7TP24) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-779677(P05426) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-915744(P02454) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|agonist:Insulin was shown to increase or decrease GLUT4 protein interactions in specific cases.|comment:"Insulin decreased GLUT4 interactions with the following proteins: Q9ER30 (Sarcosin), P09527 (Rab-7), O88960 (N-ethylmaleimide sensitive), P09456 (PKA I regulatory subunit), P27881 (Hexokinase type II), P07872 (Acyl-coenzyme A oxidase), Q6DGF1 (Isocitrate dehydrogenase), Q9EQX9 (Ubiquitin-conjugating), Q63446 (Polyubiquitin), P24268 (Cathepsin D), Q91XW0 (Heat shock protein 86), Q5FVH0 (unknown), P58405 (Striatin 3), Q62667 (Major vault protein), Q66H50 (unknown), Q09167 (splicing factor), Q9JHU5 (Arfaptin 1)."|comment:"Insulin increased GLUT4 interaction with the following proteins:Q9Z1P2 (R-actinin-1), P45592 (Cofilin), Q9QXQ0 (R-actinin-4), P26473 (ADP-ribosylation factor), P26437 (ADP-ribosylation factor),   Q7TNP1 (Basigin 2), Q6P6R2 (Dihydrolipoamide dehydrogenase),   P04797 (GAPDH), Q63081 (Protein disulfide isomerase), P29457 (47 kDa heat shock protein), Q9R1J8 (Leprecan), O88638 (Putative eps protein),   Q64375 (Synaptonemal complex)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:NDPK - Interactions involving proteins containing InterPro domain IPR001564, Nucleoside diphosphate kinase, core.	taxid:10116(rat-l6)|taxid:10116(Rattus norvegicus)	-	2006/02/15	2021/11/30	rogid:PbFY2lfrty8yw40Jq7ShR7xfuV410116	rogid:mb+sRh16NP4XU907l3dFQyJ1Kcg10116	intact-crc:44F3A2176D02515F|rigid:9RVm0UBcqQF4k06RGKO89Bg16Q8	false	myc tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P19357	uniprotkb:Q5FVH0	intact:EBI-915426|uniprotkb:P97900|ensembl:ENSRNOP00000023256	intact:EBI-920824|ensembl:ENSRNOP00000010127	psi-mi:glut4_rat(display_long)|uniprotkb:Glucose transporter type 4, insulin-responsive(gene name synonym)|uniprotkb:Slc2a4(gene name)|psi-mi:Slc2a4(display_short)|uniprotkb:Glut4(gene name synonym)	psi-mi:c1qt5_rat(display_long)|uniprotkb:C1qtnf5(gene name)|psi-mi:C1qtnf5(display_short)|uniprotkb:Ctrp5(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Foster et al. (2006)	pubmed:16396496|mint:MINT-5218203	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-921030	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2711|refseq:NP_036883.1|refseq:XP_006246658.1|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007611"(learning or memory)|go:"GO:0007614"(short-term memory)|go:"GO:0007616"(long-term memory)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010021"(amylopectin biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031550"(positive regulation of brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044381"(glucose import in response to insulin stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046323"(glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0098694"(regulation of synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0098793"(presynapse)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002441("Glucose transporter, type 4 (GLUT4)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-189200|ensembl:ENSRNOG00000017226(gene)|ensembl:ENSRNOT00000023256(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)	rgd:1308802|refseq:NP_001012123.1|ensembl:ENSRNOG00000007613(gene)|ensembl:ENSRNOT00000010127(transcript)|go:"GO:0005576"(extracellular region)|go:"GO:0005581"(collagen trimer)|go:"GO:0005615"(extracellular space)|go:"GO:0005886"(plasma membrane)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0009306"(protein secretion)|go:"GO:0016020"(membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016328"(lateral plasma membrane)|go:"GO:0030133"(transport vesicle)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042802"(identical protein binding)|go:"GO:0042995"(cell projection)|go:"GO:0048839"(inner ear development)|interpro:IPR001073(Complement C1q protein)|interpro:IPR008160(Collagen triple helix repeat)|interpro:IPR008983(Tumour necrosis factor-like)|refseq:XP_017451111.1	-	-	-	caution:"The participant EBI-349571(P68370) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919386(Q7TP47) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920972(Q5XIP9) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-916419(P11980) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919578(Q8R491) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920554(Q5U3Z7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920647(Q5U2X8) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920585(Q7TP24) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-779677(P05426) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-915744(P02454) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|agonist:Insulin was shown to increase or decrease GLUT4 protein interactions in specific cases.|comment:"Insulin decreased GLUT4 interactions with the following proteins: Q9ER30 (Sarcosin), P09527 (Rab-7), O88960 (N-ethylmaleimide sensitive), P09456 (PKA I regulatory subunit), P27881 (Hexokinase type II), P07872 (Acyl-coenzyme A oxidase), Q6DGF1 (Isocitrate dehydrogenase), Q9EQX9 (Ubiquitin-conjugating), Q63446 (Polyubiquitin), P24268 (Cathepsin D), Q91XW0 (Heat shock protein 86), Q5FVH0 (unknown), P58405 (Striatin 3), Q62667 (Major vault protein), Q66H50 (unknown), Q09167 (splicing factor), Q9JHU5 (Arfaptin 1)."|comment:"Insulin increased GLUT4 interaction with the following proteins:Q9Z1P2 (R-actinin-1), P45592 (Cofilin), Q9QXQ0 (R-actinin-4), P26473 (ADP-ribosylation factor), P26437 (ADP-ribosylation factor),   Q7TNP1 (Basigin 2), Q6P6R2 (Dihydrolipoamide dehydrogenase),   P04797 (GAPDH), Q63081 (Protein disulfide isomerase), P29457 (47 kDa heat shock protein), Q9R1J8 (Leprecan), O88638 (Putative eps protein),   Q64375 (Synaptonemal complex)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:NDPK - Interactions involving proteins containing InterPro domain IPR001564, Nucleoside diphosphate kinase, core.	taxid:10116(rat-l6)|taxid:10116(Rattus norvegicus)	-	2006/02/15	2021/11/30	rogid:PbFY2lfrty8yw40Jq7ShR7xfuV410116	rogid:y3vEU/r8KQYwsCpsIhw+ypROgB010116	intact-crc:44F3A2176D02515F|rigid:9RVm0UBcqQF4k06RGKO89Bg16Q8	false	myc tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P19357	uniprotkb:Q8R491	intact:EBI-915426|uniprotkb:P97900|ensembl:ENSRNOP00000023256	intact:EBI-919578|ensembl:ENSRNOP00000010419	psi-mi:glut4_rat(display_long)|uniprotkb:Glucose transporter type 4, insulin-responsive(gene name synonym)|uniprotkb:Slc2a4(gene name)|psi-mi:Slc2a4(display_short)|uniprotkb:Glut4(gene name synonym)	psi-mi:ehd3_rat(display_long)|uniprotkb:Ehd3(gene name)|psi-mi:Ehd3(display_short)|uniprotkb:Ehd2(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Foster et al. (2006)	pubmed:16396496|mint:MINT-5218203	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-921030	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2711|refseq:NP_036883.1|refseq:XP_006246658.1|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007611"(learning or memory)|go:"GO:0007614"(short-term memory)|go:"GO:0007616"(long-term memory)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010021"(amylopectin biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031550"(positive regulation of brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044381"(glucose import in response to insulin stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046323"(glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0098694"(regulation of synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0098793"(presynapse)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002441("Glucose transporter, type 4 (GLUT4)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-189200|ensembl:ENSRNOG00000017226(gene)|ensembl:ENSRNOT00000023256(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)	rgd:621762|refseq:NP_620245.2|ensembl:ENSRNOG00000007744(gene)|ensembl:ENSRNOT00000010419(transcript)|go:"GO:0001881"(receptor recycling)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005525"(GTP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005769"(early endosome)|go:"GO:0005829"(cytosol)|go:"GO:0006897"(endocytosis)|go:"GO:0015031"(protein transport)|go:"GO:0016197"(endosomal transport)|go:"GO:0020018"(ciliary pocket membrane)|go:"GO:0030139"(endocytic vesicle)|go:"GO:0032456"(endocytic recycling)|go:"GO:0034498"(early endosome to Golgi transport)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0055038"(recycling endosome membrane)|go:"GO:0055117"(regulation of cardiac muscle contraction)|go:"GO:0060271"(cilium assembly)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0086036"(regulation of cardiac muscle cell membrane potential)|go:"GO:0090160"(Golgi to lysosome transport)|go:"GO:1901387"(positive regulation of voltage-gated calcium channel activity)|go:"GO:1903358"(regulation of Golgi organization)|go:"GO:1903779"(regulation of cardiac conduction)|interpro:IPR000261("EPS15 homology (EH)")|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR011992(EF-Hand type)|interpro:IPR018247|interpro:IPR022812|interpro:IPR027417|interpro:IPR029951|interpro:IPR030381|interpro:IPR031692|interpro:IPR040990|mint:Q8R491|reactome:R-RNO-983231	-	-	-	caution:"The participant EBI-349571(P68370) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919386(Q7TP47) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920972(Q5XIP9) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-916419(P11980) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919578(Q8R491) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920554(Q5U3Z7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920647(Q5U2X8) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920585(Q7TP24) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-779677(P05426) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-915744(P02454) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|agonist:Insulin was shown to increase or decrease GLUT4 protein interactions in specific cases.|comment:"Insulin decreased GLUT4 interactions with the following proteins: Q9ER30 (Sarcosin), P09527 (Rab-7), O88960 (N-ethylmaleimide sensitive), P09456 (PKA I regulatory subunit), P27881 (Hexokinase type II), P07872 (Acyl-coenzyme A oxidase), Q6DGF1 (Isocitrate dehydrogenase), Q9EQX9 (Ubiquitin-conjugating), Q63446 (Polyubiquitin), P24268 (Cathepsin D), Q91XW0 (Heat shock protein 86), Q5FVH0 (unknown), P58405 (Striatin 3), Q62667 (Major vault protein), Q66H50 (unknown), Q09167 (splicing factor), Q9JHU5 (Arfaptin 1)."|comment:"Insulin increased GLUT4 interaction with the following proteins:Q9Z1P2 (R-actinin-1), P45592 (Cofilin), Q9QXQ0 (R-actinin-4), P26473 (ADP-ribosylation factor), P26437 (ADP-ribosylation factor),   Q7TNP1 (Basigin 2), Q6P6R2 (Dihydrolipoamide dehydrogenase),   P04797 (GAPDH), Q63081 (Protein disulfide isomerase), P29457 (47 kDa heat shock protein), Q9R1J8 (Leprecan), O88638 (Putative eps protein),   Q64375 (Synaptonemal complex)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:NDPK - Interactions involving proteins containing InterPro domain IPR001564, Nucleoside diphosphate kinase, core.	taxid:10116(rat-l6)|taxid:10116(Rattus norvegicus)	-	2006/02/15	2021/11/30	rogid:PbFY2lfrty8yw40Jq7ShR7xfuV410116	rogid:9FAMZNs3vpOwzZ2odo1sjLPBqlQ10116	intact-crc:44F3A2176D02515F|rigid:9RVm0UBcqQF4k06RGKO89Bg16Q8	false	myc tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P19357	uniprotkb:Q3KR80	intact:EBI-915426|uniprotkb:P97900|ensembl:ENSRNOP00000023256	intact:EBI-920817	psi-mi:glut4_rat(display_long)|uniprotkb:Glucose transporter type 4, insulin-responsive(gene name synonym)|uniprotkb:Slc2a4(gene name)|psi-mi:Slc2a4(display_short)|uniprotkb:Glut4(gene name synonym)	psi-mi:q3kr80_rat(display_long)|uniprotkb:Arsa(gene name)|psi-mi:Arsa(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Foster et al. (2006)	pubmed:16396496|mint:MINT-5218203	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-921030	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2711|refseq:NP_036883.1|refseq:XP_006246658.1|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007611"(learning or memory)|go:"GO:0007614"(short-term memory)|go:"GO:0007616"(long-term memory)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010021"(amylopectin biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031550"(positive regulation of brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044381"(glucose import in response to insulin stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046323"(glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0098694"(regulation of synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0098793"(presynapse)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002441("Glucose transporter, type 4 (GLUT4)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-189200|ensembl:ENSRNOG00000017226(gene)|ensembl:ENSRNOT00000023256(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)	interpro:IPR017850(Alkaline-phosphatase-like, core domain)|interpro:IPR000917(Sulphatase)|interpro:IPR024607|go:"GO:0008484"(sulfuric ester hydrolase activity)	-	-	-	caution:"The participant EBI-349571(P68370) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919386(Q7TP47) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920972(Q5XIP9) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-916419(P11980) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919578(Q8R491) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920554(Q5U3Z7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920647(Q5U2X8) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920585(Q7TP24) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-779677(P05426) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-915744(P02454) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|agonist:Insulin was shown to increase or decrease GLUT4 protein interactions in specific cases.|comment:"Insulin decreased GLUT4 interactions with the following proteins: Q9ER30 (Sarcosin), P09527 (Rab-7), O88960 (N-ethylmaleimide sensitive), P09456 (PKA I regulatory subunit), P27881 (Hexokinase type II), P07872 (Acyl-coenzyme A oxidase), Q6DGF1 (Isocitrate dehydrogenase), Q9EQX9 (Ubiquitin-conjugating), Q63446 (Polyubiquitin), P24268 (Cathepsin D), Q91XW0 (Heat shock protein 86), Q5FVH0 (unknown), P58405 (Striatin 3), Q62667 (Major vault protein), Q66H50 (unknown), Q09167 (splicing factor), Q9JHU5 (Arfaptin 1)."|comment:"Insulin increased GLUT4 interaction with the following proteins:Q9Z1P2 (R-actinin-1), P45592 (Cofilin), Q9QXQ0 (R-actinin-4), P26473 (ADP-ribosylation factor), P26437 (ADP-ribosylation factor),   Q7TNP1 (Basigin 2), Q6P6R2 (Dihydrolipoamide dehydrogenase),   P04797 (GAPDH), Q63081 (Protein disulfide isomerase), P29457 (47 kDa heat shock protein), Q9R1J8 (Leprecan), O88638 (Putative eps protein),   Q64375 (Synaptonemal complex)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:NDPK - Interactions involving proteins containing InterPro domain IPR001564, Nucleoside diphosphate kinase, core.	taxid:10116(rat-l6)|taxid:10116(Rattus norvegicus)	-	2006/02/15	2021/11/30	rogid:PbFY2lfrty8yw40Jq7ShR7xfuV410116	rogid:edjdiohCKP6aHi19SU1be33Orf410116	intact-crc:44F3A2176D02515F|rigid:9RVm0UBcqQF4k06RGKO89Bg16Q8	false	myc tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P19357	uniprotkb:Q32KK2	intact:EBI-915426|uniprotkb:P97900|ensembl:ENSRNOP00000023256	intact:EBI-920810|ensembl:ENSRNOP00000017782	psi-mi:glut4_rat(display_long)|uniprotkb:Glucose transporter type 4, insulin-responsive(gene name synonym)|uniprotkb:Slc2a4(gene name)|psi-mi:Slc2a4(display_short)|uniprotkb:Glut4(gene name synonym)	psi-mi:q32kk2_rat(display_long)|uniprotkb:Arsa(gene name)|psi-mi:Arsa(display_short)|uniprotkb:rCG_59222(orf name)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Foster et al. (2006)	pubmed:16396496|mint:MINT-5218203	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-921030	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2711|refseq:NP_036883.1|refseq:XP_006246658.1|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007611"(learning or memory)|go:"GO:0007614"(short-term memory)|go:"GO:0007616"(long-term memory)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010021"(amylopectin biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031550"(positive regulation of brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044381"(glucose import in response to insulin stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046323"(glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0098694"(regulation of synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0098793"(presynapse)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002441("Glucose transporter, type 4 (GLUT4)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-189200|ensembl:ENSRNOG00000017226(gene)|ensembl:ENSRNOT00000023256(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)	rgd:1310381|refseq:NP_001030105.2|ensembl:ENSRNOG00000012953(gene)|ensembl:ENSRNOT00000017783(transcript)|go:"GO:0001669"(acrosomal vesicle)|go:"GO:0004065"(arylsulfatase activity)|go:"GO:0004098"(cerebroside-sulfatase activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005768"(endosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0006914"(autophagy)|go:"GO:0007339"(binding of sperm to zona pellucida)|go:"GO:0007417"(central nervous system development)|go:"GO:0007584"(response to nutrient)|go:"GO:0008484"(sulfuric ester hydrolase activity)|go:"GO:0009268"(response to pH)|go:"GO:0016021"(integral component of membrane)|go:"GO:0031232"(extrinsic component of external side of plasma membrane)|go:"GO:0043627"(response to estrogen)|go:"GO:0045471"(response to ethanol)|go:"GO:0051597"(response to methylmercury)|interpro:IPR000917(Sulphatase)|interpro:IPR017850(Alkaline-phosphatase-like, core domain)|interpro:IPR024607|reactome:R-RNO-1660662|reactome:R-RNO-1663150|reactome:R-RNO-6798695|refseq:XP_017450375.1	-	-	-	caution:"The participant EBI-349571(P68370) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919386(Q7TP47) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920972(Q5XIP9) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-916419(P11980) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919578(Q8R491) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920554(Q5U3Z7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920647(Q5U2X8) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920585(Q7TP24) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-779677(P05426) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-915744(P02454) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|agonist:Insulin was shown to increase or decrease GLUT4 protein interactions in specific cases.|comment:"Insulin decreased GLUT4 interactions with the following proteins: Q9ER30 (Sarcosin), P09527 (Rab-7), O88960 (N-ethylmaleimide sensitive), P09456 (PKA I regulatory subunit), P27881 (Hexokinase type II), P07872 (Acyl-coenzyme A oxidase), Q6DGF1 (Isocitrate dehydrogenase), Q9EQX9 (Ubiquitin-conjugating), Q63446 (Polyubiquitin), P24268 (Cathepsin D), Q91XW0 (Heat shock protein 86), Q5FVH0 (unknown), P58405 (Striatin 3), Q62667 (Major vault protein), Q66H50 (unknown), Q09167 (splicing factor), Q9JHU5 (Arfaptin 1)."|comment:"Insulin increased GLUT4 interaction with the following proteins:Q9Z1P2 (R-actinin-1), P45592 (Cofilin), Q9QXQ0 (R-actinin-4), P26473 (ADP-ribosylation factor), P26437 (ADP-ribosylation factor),   Q7TNP1 (Basigin 2), Q6P6R2 (Dihydrolipoamide dehydrogenase),   P04797 (GAPDH), Q63081 (Protein disulfide isomerase), P29457 (47 kDa heat shock protein), Q9R1J8 (Leprecan), O88638 (Putative eps protein),   Q64375 (Synaptonemal complex)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:NDPK - Interactions involving proteins containing InterPro domain IPR001564, Nucleoside diphosphate kinase, core.	taxid:10116(rat-l6)|taxid:10116(Rattus norvegicus)	-	2006/02/15	2021/11/30	rogid:PbFY2lfrty8yw40Jq7ShR7xfuV410116	rogid:VtKWuzFVGwnztjBMygn+p2jW3Ng10116	intact-crc:44F3A2176D02515F|rigid:9RVm0UBcqQF4k06RGKO89Bg16Q8	false	myc tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P19357	uniprotkb:Q66H12	intact:EBI-915426|uniprotkb:P97900|ensembl:ENSRNOP00000023256	intact:EBI-920804|ensembl:ENSRNOP00000060590	psi-mi:glut4_rat(display_long)|uniprotkb:Glucose transporter type 4, insulin-responsive(gene name synonym)|uniprotkb:Slc2a4(gene name)|psi-mi:Slc2a4(display_short)|uniprotkb:Glut4(gene name synonym)	psi-mi:nagab_rat(display_long)|uniprotkb:Naga(gene name)|psi-mi:Naga(display_short)|uniprotkb:Alpha-galactosidase B(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Foster et al. (2006)	pubmed:16396496|mint:MINT-5218203	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-921030	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2711|refseq:NP_036883.1|refseq:XP_006246658.1|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007611"(learning or memory)|go:"GO:0007614"(short-term memory)|go:"GO:0007616"(long-term memory)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010021"(amylopectin biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031550"(positive regulation of brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044381"(glucose import in response to insulin stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046323"(glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0098694"(regulation of synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0098793"(presynapse)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002441("Glucose transporter, type 4 (GLUT4)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-189200|ensembl:ENSRNOG00000017226(gene)|ensembl:ENSRNOT00000023256(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)	rgd:1306025|refseq:NP_001012120.1|refseq:XP_006242149.1|refseq:XP_006242150.1|ensembl:ENSRNOG00000008064(gene)|ensembl:ENSRNOT00000068020(transcript)|go:"GO:0004557"(alpha-galactosidase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0008456"(alpha-N-acetylgalactosaminidase activity)|go:"GO:0009311"(oligosaccharide metabolic process)|go:"GO:0016052"(carbohydrate catabolic process)|go:"GO:0016139"(glycoside catabolic process)|go:"GO:0019377"(glycolipid catabolic process)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0046477"(glycosylceramide catabolic process)|interpro:IPR000111(Glycoside hydrolase, clan GH-D)|interpro:IPR002241(Glycoside hydrolase, family 27)|interpro:IPR013780(Glycosyl hydrolase, family 13, all-beta)|interpro:IPR013785(Aldolase-type TIM barrel)|interpro:IPR017853(Glycoside hydrolase, catalytic core)|interpro:IPR035373	-	-	-	caution:"The participant EBI-349571(P68370) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919386(Q7TP47) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920972(Q5XIP9) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-916419(P11980) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919578(Q8R491) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920554(Q5U3Z7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920647(Q5U2X8) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920585(Q7TP24) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-779677(P05426) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-915744(P02454) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|agonist:Insulin was shown to increase or decrease GLUT4 protein interactions in specific cases.|comment:"Insulin decreased GLUT4 interactions with the following proteins: Q9ER30 (Sarcosin), P09527 (Rab-7), O88960 (N-ethylmaleimide sensitive), P09456 (PKA I regulatory subunit), P27881 (Hexokinase type II), P07872 (Acyl-coenzyme A oxidase), Q6DGF1 (Isocitrate dehydrogenase), Q9EQX9 (Ubiquitin-conjugating), Q63446 (Polyubiquitin), P24268 (Cathepsin D), Q91XW0 (Heat shock protein 86), Q5FVH0 (unknown), P58405 (Striatin 3), Q62667 (Major vault protein), Q66H50 (unknown), Q09167 (splicing factor), Q9JHU5 (Arfaptin 1)."|comment:"Insulin increased GLUT4 interaction with the following proteins:Q9Z1P2 (R-actinin-1), P45592 (Cofilin), Q9QXQ0 (R-actinin-4), P26473 (ADP-ribosylation factor), P26437 (ADP-ribosylation factor),   Q7TNP1 (Basigin 2), Q6P6R2 (Dihydrolipoamide dehydrogenase),   P04797 (GAPDH), Q63081 (Protein disulfide isomerase), P29457 (47 kDa heat shock protein), Q9R1J8 (Leprecan), O88638 (Putative eps protein),   Q64375 (Synaptonemal complex)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:NDPK - Interactions involving proteins containing InterPro domain IPR001564, Nucleoside diphosphate kinase, core.	taxid:10116(rat-l6)|taxid:10116(Rattus norvegicus)	-	2006/02/15	2021/11/30	rogid:PbFY2lfrty8yw40Jq7ShR7xfuV410116	rogid:f/hbrVtqjKqMGdVypUlV1WMjsa810116	intact-crc:44F3A2176D02515F|rigid:9RVm0UBcqQF4k06RGKO89Bg16Q8	false	myc tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P19357	uniprotkb:P11598	intact:EBI-915426|uniprotkb:P97900|ensembl:ENSRNOP00000023256	intact:EBI-916347	psi-mi:glut4_rat(display_long)|uniprotkb:Glucose transporter type 4, insulin-responsive(gene name synonym)|uniprotkb:Slc2a4(gene name)|psi-mi:Slc2a4(display_short)|uniprotkb:Glut4(gene name synonym)	psi-mi:pdia3_rat(display_long)|uniprotkb:Disulfide isomerase ER-60(gene name synonym)|uniprotkb:Endoplasmic reticulum resident protein 60(gene name synonym)|uniprotkb:58 kDa microsomal protein(gene name synonym)|uniprotkb:Endoplasmic reticulum resident protein 57(gene name synonym)|uniprotkb:58 kDa glucose-regulated protein(gene name synonym)|uniprotkb:HIP-70(gene name synonym)|uniprotkb:Q-2(gene name synonym)|uniprotkb:Pdia3(gene name)|psi-mi:Pdia3(display_short)|uniprotkb:Erp60(gene name synonym)|uniprotkb:Grp58(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Foster et al. (2006)	pubmed:16396496|mint:MINT-5218203	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-921030	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2711|refseq:NP_036883.1|refseq:XP_006246658.1|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007611"(learning or memory)|go:"GO:0007614"(short-term memory)|go:"GO:0007616"(long-term memory)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010021"(amylopectin biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031550"(positive regulation of brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044381"(glucose import in response to insulin stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046323"(glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0098694"(regulation of synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0098793"(presynapse)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002441("Glucose transporter, type 4 (GLUT4)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-189200|ensembl:ENSRNOG00000017226(gene)|ensembl:ENSRNOT00000023256(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)	rgd:68430|refseq:NP_059015.1|interpro:IPR005788(Disulphide isomerase)|interpro:IPR005792(Protein disulphide isomerase)|interpro:IPR017937|interpro:IPR013766(Thioredoxin domain)|go:"GO:0042288"(MHC class I protein binding)|go:"GO:0042470"(melanosome)|go:"GO:0042802"(identical protein binding)|go:"GO:0001666"(response to hypoxia)|go:"GO:0042824"(MHC class I peptide loading complex)|go:"GO:0001669"(acrosomal vesicle)|go:"GO:0042825"(TAP complex)|go:"GO:0044321"(response to leptin)|go:"GO:0002931"(response to ischemia)|go:"GO:0003756"(protein disulfide isomerase activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005790"(smooth endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0006457"(protein folding)|go:"GO:0007623"(circadian rhythm)|go:"GO:0008233"(peptidase activity)|go:"GO:0009986"(cell surface)|go:"GO:0015035"(protein-disulfide reductase activity)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019153"("protein-disulfide reductase (glutathione) activity")|go:"GO:0031667"(response to nutrient levels)|go:"GO:0033595"(response to genistein)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0045471"(response to ethanol)|go:"GO:0055093"(response to hyperoxia)|go:"GO:0071305"(cellular response to vitamin D)|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|go:"GO:0098761"(cellular response to interleukin-7)|go:"GO:1901423"(response to benzene)|go:"GO:1903334"(positive regulation of protein folding)|go:"GO:1904148"(cellular response to nonylphenol)|go:"GO:2001238"(positive regulation of extrinsic apoptotic signaling pathway)|reactome:R-RNO-901042|reactome:R-RNO-983170|mint:P11598|interpro:IPR036249|interpro:IPR041868	-	-	-	caution:"The participant EBI-349571(P68370) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919386(Q7TP47) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920972(Q5XIP9) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-916419(P11980) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919578(Q8R491) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920554(Q5U3Z7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920647(Q5U2X8) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920585(Q7TP24) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-779677(P05426) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-915744(P02454) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|agonist:Insulin was shown to increase or decrease GLUT4 protein interactions in specific cases.|comment:"Insulin decreased GLUT4 interactions with the following proteins: Q9ER30 (Sarcosin), P09527 (Rab-7), O88960 (N-ethylmaleimide sensitive), P09456 (PKA I regulatory subunit), P27881 (Hexokinase type II), P07872 (Acyl-coenzyme A oxidase), Q6DGF1 (Isocitrate dehydrogenase), Q9EQX9 (Ubiquitin-conjugating), Q63446 (Polyubiquitin), P24268 (Cathepsin D), Q91XW0 (Heat shock protein 86), Q5FVH0 (unknown), P58405 (Striatin 3), Q62667 (Major vault protein), Q66H50 (unknown), Q09167 (splicing factor), Q9JHU5 (Arfaptin 1)."|comment:"Insulin increased GLUT4 interaction with the following proteins:Q9Z1P2 (R-actinin-1), P45592 (Cofilin), Q9QXQ0 (R-actinin-4), P26473 (ADP-ribosylation factor), P26437 (ADP-ribosylation factor),   Q7TNP1 (Basigin 2), Q6P6R2 (Dihydrolipoamide dehydrogenase),   P04797 (GAPDH), Q63081 (Protein disulfide isomerase), P29457 (47 kDa heat shock protein), Q9R1J8 (Leprecan), O88638 (Putative eps protein),   Q64375 (Synaptonemal complex)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:NDPK - Interactions involving proteins containing InterPro domain IPR001564, Nucleoside diphosphate kinase, core.	taxid:10116(rat-l6)|taxid:10116(Rattus norvegicus)	-	2006/02/15	2021/11/30	rogid:PbFY2lfrty8yw40Jq7ShR7xfuV410116	rogid:l8gVAVgIclV0nr1n2t2XF33giuM10116	intact-crc:44F3A2176D02515F|rigid:9RVm0UBcqQF4k06RGKO89Bg16Q8	false	myc tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P19357	uniprotkb:P61212	intact:EBI-915426|uniprotkb:P97900|ensembl:ENSRNOP00000023256	intact:EBI-917882|uniprotkb:P41276|ensembl:ENSRNOP00000007623	psi-mi:glut4_rat(display_long)|uniprotkb:Glucose transporter type 4, insulin-responsive(gene name synonym)|uniprotkb:Slc2a4(gene name)|psi-mi:Slc2a4(display_short)|uniprotkb:Glut4(gene name synonym)	psi-mi:arl1_rat(display_long)|uniprotkb:Arl1(gene name)|psi-mi:Arl1(display_short)|uniprotkb:Arf7(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Foster et al. (2006)	pubmed:16396496|mint:MINT-5218203	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-921030	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2711|refseq:NP_036883.1|refseq:XP_006246658.1|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007611"(learning or memory)|go:"GO:0007614"(short-term memory)|go:"GO:0007616"(long-term memory)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010021"(amylopectin biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031550"(positive regulation of brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044381"(glucose import in response to insulin stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046323"(glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0098694"(regulation of synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0098793"(presynapse)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002441("Glucose transporter, type 4 (GLUT4)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-189200|ensembl:ENSRNOG00000017226(gene)|ensembl:ENSRNOT00000023256(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)	rgd:621326|refseq:NP_071780.1|ensembl:ENSRNOG00000005763(gene)|ensembl:ENSRNOT00000007623(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0007030"(Golgi organization)|go:"GO:0008047"(enzyme activator activity)|go:"GO:0009404"(toxin metabolic process)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0031584"(activation of phospholipase D activity)|go:"GO:0034067"(protein localization to Golgi apparatus)|go:"GO:0042147"(retrograde transport, endosome to Golgi)|go:"GO:0046872"(metal ion binding)|go:"GO:0048193"(Golgi vesicle transport)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR006689(ARF/SAR superfamily)|interpro:IPR027417|rcsb pdb:1R4A|reactome:R-RNO-6811440	-	-	-	caution:"The participant EBI-349571(P68370) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919386(Q7TP47) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920972(Q5XIP9) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-916419(P11980) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919578(Q8R491) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920554(Q5U3Z7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920647(Q5U2X8) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920585(Q7TP24) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-779677(P05426) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-915744(P02454) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|agonist:Insulin was shown to increase or decrease GLUT4 protein interactions in specific cases.|comment:"Insulin decreased GLUT4 interactions with the following proteins: Q9ER30 (Sarcosin), P09527 (Rab-7), O88960 (N-ethylmaleimide sensitive), P09456 (PKA I regulatory subunit), P27881 (Hexokinase type II), P07872 (Acyl-coenzyme A oxidase), Q6DGF1 (Isocitrate dehydrogenase), Q9EQX9 (Ubiquitin-conjugating), Q63446 (Polyubiquitin), P24268 (Cathepsin D), Q91XW0 (Heat shock protein 86), Q5FVH0 (unknown), P58405 (Striatin 3), Q62667 (Major vault protein), Q66H50 (unknown), Q09167 (splicing factor), Q9JHU5 (Arfaptin 1)."|comment:"Insulin increased GLUT4 interaction with the following proteins:Q9Z1P2 (R-actinin-1), P45592 (Cofilin), Q9QXQ0 (R-actinin-4), P26473 (ADP-ribosylation factor), P26437 (ADP-ribosylation factor),   Q7TNP1 (Basigin 2), Q6P6R2 (Dihydrolipoamide dehydrogenase),   P04797 (GAPDH), Q63081 (Protein disulfide isomerase), P29457 (47 kDa heat shock protein), Q9R1J8 (Leprecan), O88638 (Putative eps protein),   Q64375 (Synaptonemal complex)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:NDPK - Interactions involving proteins containing InterPro domain IPR001564, Nucleoside diphosphate kinase, core.	taxid:10116(rat-l6)|taxid:10116(Rattus norvegicus)	-	2006/02/15	2021/11/30	rogid:PbFY2lfrty8yw40Jq7ShR7xfuV410116	rogid:qC7ZdwTn0xQl0jsQIk/dBPDBn2Q10116	intact-crc:44F3A2176D02515F|rigid:9RVm0UBcqQF4k06RGKO89Bg16Q8	false	myc tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P19357	uniprotkb:P61206	intact:EBI-915426|uniprotkb:P97900|ensembl:ENSRNOP00000023256	intact:EBI-917872|uniprotkb:P16587|ensembl:ENSRNOP00000069538	psi-mi:glut4_rat(display_long)|uniprotkb:Glucose transporter type 4, insulin-responsive(gene name synonym)|uniprotkb:Slc2a4(gene name)|psi-mi:Slc2a4(display_short)|uniprotkb:Glut4(gene name synonym)	psi-mi:arf3_rat(display_long)|uniprotkb:Liver regeneration-related protein LRRG202(gene name synonym)|uniprotkb:Arf3(gene name)|psi-mi:Arf3(display_short)|uniprotkb:Ac1-253(orf name)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Foster et al. (2006)	pubmed:16396496|mint:MINT-5218203	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-921030	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2711|refseq:NP_036883.1|refseq:XP_006246658.1|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007611"(learning or memory)|go:"GO:0007614"(short-term memory)|go:"GO:0007616"(long-term memory)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010021"(amylopectin biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031550"(positive regulation of brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044381"(glucose import in response to insulin stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046323"(glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0098694"(regulation of synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0098793"(presynapse)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002441("Glucose transporter, type 4 (GLUT4)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-189200|ensembl:ENSRNOG00000017226(gene)|ensembl:ENSRNOT00000023256(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)	rgd:621273|refseq:NP_543180.1|refseq:XP_006257382.1|refseq:XP_017450124.1|refseq:XP_017450125.1|ensembl:ENSRNOG00000054775(gene)|ensembl:ENSRNOT00000077884(transcript)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006890"(retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0048471"(perinuclear region of cytoplasm)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR006689(ARF/SAR superfamily)|interpro:IPR027417|reactome:R-RNO-1660514|reactome:R-RNO-6807878|reactome:R-RNO-6811434	-	-	-	caution:"The participant EBI-349571(P68370) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919386(Q7TP47) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920972(Q5XIP9) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-916419(P11980) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919578(Q8R491) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920554(Q5U3Z7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920647(Q5U2X8) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920585(Q7TP24) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-779677(P05426) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-915744(P02454) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|agonist:Insulin was shown to increase or decrease GLUT4 protein interactions in specific cases.|comment:"Insulin decreased GLUT4 interactions with the following proteins: Q9ER30 (Sarcosin), P09527 (Rab-7), O88960 (N-ethylmaleimide sensitive), P09456 (PKA I regulatory subunit), P27881 (Hexokinase type II), P07872 (Acyl-coenzyme A oxidase), Q6DGF1 (Isocitrate dehydrogenase), Q9EQX9 (Ubiquitin-conjugating), Q63446 (Polyubiquitin), P24268 (Cathepsin D), Q91XW0 (Heat shock protein 86), Q5FVH0 (unknown), P58405 (Striatin 3), Q62667 (Major vault protein), Q66H50 (unknown), Q09167 (splicing factor), Q9JHU5 (Arfaptin 1)."|comment:"Insulin increased GLUT4 interaction with the following proteins:Q9Z1P2 (R-actinin-1), P45592 (Cofilin), Q9QXQ0 (R-actinin-4), P26473 (ADP-ribosylation factor), P26437 (ADP-ribosylation factor),   Q7TNP1 (Basigin 2), Q6P6R2 (Dihydrolipoamide dehydrogenase),   P04797 (GAPDH), Q63081 (Protein disulfide isomerase), P29457 (47 kDa heat shock protein), Q9R1J8 (Leprecan), O88638 (Putative eps protein),   Q64375 (Synaptonemal complex)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:NDPK - Interactions involving proteins containing InterPro domain IPR001564, Nucleoside diphosphate kinase, core.	taxid:10116(rat-l6)|taxid:10116(Rattus norvegicus)	-	2006/02/15	2021/11/30	rogid:PbFY2lfrty8yw40Jq7ShR7xfuV410116	rogid:np09WjdbXRu9vgMbiXn9EA3ExqA10116	intact-crc:44F3A2176D02515F|rigid:9RVm0UBcqQF4k06RGKO89Bg16Q8	false	myc tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P19357	uniprotkb:P61107	intact:EBI-915426|uniprotkb:P97900|ensembl:ENSRNOP00000023256	intact:EBI-917845|uniprotkb:P35287|uniprotkb:Q969L0|uniprotkb:Q9UI11	psi-mi:glut4_rat(display_long)|uniprotkb:Glucose transporter type 4, insulin-responsive(gene name synonym)|uniprotkb:Slc2a4(gene name)|psi-mi:Slc2a4(display_short)|uniprotkb:Glut4(gene name synonym)	psi-mi:rab14_rat(display_long)|uniprotkb:Rab14(gene name)|psi-mi:Rab14(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Foster et al. (2006)	pubmed:16396496|mint:MINT-5218203	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-921030	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2711|refseq:NP_036883.1|refseq:XP_006246658.1|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007611"(learning or memory)|go:"GO:0007614"(short-term memory)|go:"GO:0007616"(long-term memory)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010021"(amylopectin biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031550"(positive regulation of brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044381"(glucose import in response to insulin stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046323"(glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0098694"(regulation of synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0098793"(presynapse)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002441("Glucose transporter, type 4 (GLUT4)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-189200|ensembl:ENSRNOG00000017226(gene)|ensembl:ENSRNOT00000023256(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)	rgd:620881|refseq:NP_446041.1|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR001806(Ras GTPase)|interpro:IPR030702|interpro:IPR027417|mint:P61107|go:"GO:0000139"(Golgi membrane)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005764"(lysosome)|go:"GO:0005769"(early endosome)|go:"GO:0005770"(late endosome)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0005795"(Golgi stack)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006895"(Golgi to endosome transport)|go:"GO:0007589"(body fluid secretion)|go:"GO:0008543"(fibroblast growth factor receptor signaling pathway)|go:"GO:0012505"(endomembrane system)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019003"(GDP binding)|go:"GO:0030133"(transport vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031489"(myosin V binding)|go:"GO:0031901"(early endosome membrane)|go:"GO:0032456"(endocytic recycling)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0042175"(nuclear outer membrane-endoplasmic reticulum membrane network)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0045176"(apical protein localization)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0045995"(regulation of embryonic development)|go:"GO:0046907"(intracellular transport)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0055037"(recycling endosome)|go:"GO:0090387"(phagolysosome assembly involved in apoptotic cell clearance)|go:"GO:0097208"(alveolar lamellar body)|go:"GO:0098993"(anchored component of synaptic vesicle membrane)|reactome:R-RNO-1660499|reactome:R-RNO-6798695|reactome:R-RNO-8873719|reactome:R-RNO-8876198	-	-	-	caution:"The participant EBI-349571(P68370) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919386(Q7TP47) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920972(Q5XIP9) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-916419(P11980) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919578(Q8R491) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920554(Q5U3Z7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920647(Q5U2X8) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920585(Q7TP24) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-779677(P05426) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-915744(P02454) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|agonist:Insulin was shown to increase or decrease GLUT4 protein interactions in specific cases.|comment:"Insulin decreased GLUT4 interactions with the following proteins: Q9ER30 (Sarcosin), P09527 (Rab-7), O88960 (N-ethylmaleimide sensitive), P09456 (PKA I regulatory subunit), P27881 (Hexokinase type II), P07872 (Acyl-coenzyme A oxidase), Q6DGF1 (Isocitrate dehydrogenase), Q9EQX9 (Ubiquitin-conjugating), Q63446 (Polyubiquitin), P24268 (Cathepsin D), Q91XW0 (Heat shock protein 86), Q5FVH0 (unknown), P58405 (Striatin 3), Q62667 (Major vault protein), Q66H50 (unknown), Q09167 (splicing factor), Q9JHU5 (Arfaptin 1)."|comment:"Insulin increased GLUT4 interaction with the following proteins:Q9Z1P2 (R-actinin-1), P45592 (Cofilin), Q9QXQ0 (R-actinin-4), P26473 (ADP-ribosylation factor), P26437 (ADP-ribosylation factor),   Q7TNP1 (Basigin 2), Q6P6R2 (Dihydrolipoamide dehydrogenase),   P04797 (GAPDH), Q63081 (Protein disulfide isomerase), P29457 (47 kDa heat shock protein), Q9R1J8 (Leprecan), O88638 (Putative eps protein),   Q64375 (Synaptonemal complex)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:NDPK - Interactions involving proteins containing InterPro domain IPR001564, Nucleoside diphosphate kinase, core.	taxid:10116(rat-l6)|taxid:10116(Rattus norvegicus)	-	2006/02/15	2021/11/30	rogid:PbFY2lfrty8yw40Jq7ShR7xfuV410116	rogid:KPCWiyc6plQCbqAnsREsHrR61LM10116	intact-crc:44F3A2176D02515F|rigid:9RVm0UBcqQF4k06RGKO89Bg16Q8	false	myc tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P19357	uniprotkb:P61023	intact:EBI-915426|uniprotkb:P97900|ensembl:ENSRNOP00000023256	intact:EBI-917838|uniprotkb:Q62877|ensembl:ENSRNOP00000053243	psi-mi:glut4_rat(display_long)|uniprotkb:Glucose transporter type 4, insulin-responsive(gene name synonym)|uniprotkb:Slc2a4(gene name)|psi-mi:Slc2a4(display_short)|uniprotkb:Glut4(gene name synonym)	psi-mi:chp1_rat(display_long)|uniprotkb:Chp1(gene name)|psi-mi:Chp1(display_short)|uniprotkb:Calcineurin B-like protein(gene name synonym)|uniprotkb:Calcium-binding protein CHP(gene name synonym)|uniprotkb:Calcium-binding protein p22(gene name synonym)|uniprotkb:Chp(gene name synonym)|uniprotkb:EF-hand calcium-binding domain-containing protein p22(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Foster et al. (2006)	pubmed:16396496|mint:MINT-5218203	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-921030	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2711|refseq:NP_036883.1|refseq:XP_006246658.1|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007611"(learning or memory)|go:"GO:0007614"(short-term memory)|go:"GO:0007616"(long-term memory)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010021"(amylopectin biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031550"(positive regulation of brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044381"(glucose import in response to insulin stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046323"(glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0098694"(regulation of synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0098793"(presynapse)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002441("Glucose transporter, type 4 (GLUT4)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-189200|ensembl:ENSRNOG00000017226(gene)|ensembl:ENSRNOT00000023256(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)	rgd:620447|refseq:NP_077053.1|ensembl:ENSRNOG00000004742(gene)|ensembl:ENSRNOT00000056405(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001578"(microtubule bundle formation)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0004860"(protein kinase inhibitor activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005634"(nucleus)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005793"(endoplasmic reticulum-Golgi intermediate compartment)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0006611"(protein export from nucleus)|go:"GO:0006903"(vesicle targeting)|go:"GO:0006906"(vesicle fusion)|go:"GO:0008017"(microtubule binding)|go:"GO:0010923"(negative regulation of phosphatase activity)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0019900"(kinase binding)|go:"GO:0022406"(membrane docking)|go:"GO:0030133"(transport vesicle)|go:"GO:0031122"(cytoplasmic microtubule organization)|go:"GO:0031397"(negative regulation of protein ubiquitination)|go:"GO:0031953"(negative regulation of protein autophosphorylation)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032417"("positive regulation of sodium:proton antiporter activity")|go:"GO:0042308"(negative regulation of protein import into nucleus)|go:"GO:0048306"(calcium-dependent protein binding)|go:"GO:0050821"(protein stabilization)|go:"GO:0051222"(positive regulation of protein transport)|go:"GO:0051259"(protein complex oligomerization)|go:"GO:0051453"(regulation of intracellular pH)|go:"GO:0060050"(positive regulation of protein glycosylation)|go:"GO:0061024"(membrane organization)|go:"GO:0061025"(membrane fusion)|go:"GO:0070885"(negative regulation of calcineurin-NFAT signaling cascade)|go:"GO:0071073"(positive regulation of phospholipid biosynthetic process)|go:"GO:0071468"(cellular response to acidic pH)|go:"GO:0090314"(positive regulation of protein targeting to membrane)|go:"GO:1901214"(regulation of neuron death)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR011992(EF-Hand type)|interpro:IPR018247|mint:P61023|rcsb pdb:2CT9|reactome:R-RNO-2160916|go:"GO:0005737"(cytoplasm)	-	-	-	caution:"The participant EBI-349571(P68370) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919386(Q7TP47) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920972(Q5XIP9) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-916419(P11980) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919578(Q8R491) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920554(Q5U3Z7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920647(Q5U2X8) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920585(Q7TP24) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-779677(P05426) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-915744(P02454) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|agonist:Insulin was shown to increase or decrease GLUT4 protein interactions in specific cases.|comment:"Insulin decreased GLUT4 interactions with the following proteins: Q9ER30 (Sarcosin), P09527 (Rab-7), O88960 (N-ethylmaleimide sensitive), P09456 (PKA I regulatory subunit), P27881 (Hexokinase type II), P07872 (Acyl-coenzyme A oxidase), Q6DGF1 (Isocitrate dehydrogenase), Q9EQX9 (Ubiquitin-conjugating), Q63446 (Polyubiquitin), P24268 (Cathepsin D), Q91XW0 (Heat shock protein 86), Q5FVH0 (unknown), P58405 (Striatin 3), Q62667 (Major vault protein), Q66H50 (unknown), Q09167 (splicing factor), Q9JHU5 (Arfaptin 1)."|comment:"Insulin increased GLUT4 interaction with the following proteins:Q9Z1P2 (R-actinin-1), P45592 (Cofilin), Q9QXQ0 (R-actinin-4), P26473 (ADP-ribosylation factor), P26437 (ADP-ribosylation factor),   Q7TNP1 (Basigin 2), Q6P6R2 (Dihydrolipoamide dehydrogenase),   P04797 (GAPDH), Q63081 (Protein disulfide isomerase), P29457 (47 kDa heat shock protein), Q9R1J8 (Leprecan), O88638 (Putative eps protein),   Q64375 (Synaptonemal complex)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:NDPK - Interactions involving proteins containing InterPro domain IPR001564, Nucleoside diphosphate kinase, core.	taxid:10116(rat-l6)|taxid:10116(Rattus norvegicus)	-	2006/02/15	2021/11/30	rogid:PbFY2lfrty8yw40Jq7ShR7xfuV410116	rogid:xBd8WuYr8Uekzj+ou+oU5IiBcco10116	intact-crc:44F3A2176D02515F|rigid:9RVm0UBcqQF4k06RGKO89Bg16Q8	false	myc tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P19357	uniprotkb:P60901	intact:EBI-915426|uniprotkb:P97900|ensembl:ENSRNOP00000023256	intact:EBI-357805|uniprotkb:P34062|ensembl:ENSRNOP00000009666	psi-mi:glut4_rat(display_long)|uniprotkb:Glucose transporter type 4, insulin-responsive(gene name synonym)|uniprotkb:Slc2a4(gene name)|psi-mi:Slc2a4(display_short)|uniprotkb:Glut4(gene name synonym)	psi-mi:psa6_rat(display_long)|uniprotkb:Psma6(gene name)|psi-mi:Psma6(display_short)|uniprotkb:Proteasome iota chain(gene name synonym)|uniprotkb:Macropain iota chain(gene name synonym)|uniprotkb:Multicatalytic endopeptidase complex iota chain(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Foster et al. (2006)	pubmed:16396496|mint:MINT-5218203	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-921030	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2711|refseq:NP_036883.1|refseq:XP_006246658.1|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007611"(learning or memory)|go:"GO:0007614"(short-term memory)|go:"GO:0007616"(long-term memory)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010021"(amylopectin biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031550"(positive regulation of brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044381"(glucose import in response to insulin stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046323"(glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0098694"(regulation of synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0098793"(presynapse)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002441("Glucose transporter, type 4 (GLUT4)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-189200|ensembl:ENSRNOG00000017226(gene)|ensembl:ENSRNOT00000023256(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)	rgd:61849|refseq:NP_058979.1|reactome:R-RNO-382556|reactome:R-RNO-450408|reactome:R-RNO-4608870|reactome:R-RNO-4641257|reactome:R-RNO-4641258|reactome:R-RNO-5358346|reactome:R-RNO-5607761|reactome:R-RNO-5610780|reactome:R-RNO-5610785|reactome:R-RNO-5632684|reactome:R-RNO-5658442|reactome:R-RNO-5668541|reactome:R-RNO-5676590|reactome:R-RNO-5687128|reactome:R-RNO-5689603|reactome:R-RNO-5689880|reactome:R-RNO-68827|reactome:R-RNO-68949|reactome:R-RNO-69017|reactome:R-RNO-69481|reactome:R-RNO-69601|reactome:R-RNO-75815|reactome:R-RNO-8852276|reactome:R-RNO-8854050|reactome:R-RNO-8932339|reactome:R-RNO-8939236|reactome:R-RNO-8941858|reactome:R-RNO-8948751|reactome:R-RNO-8951664|reactome:R-RNO-983168|reactome:R-RNO-350562|ensembl:ENSRNOG00000007114(gene)|ensembl:ENSRNOT00000009666(transcript)|go:"GO:0000502"(proteasome complex)|go:"GO:0000932"(P-body)|go:"GO:0003723"(RNA binding)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005839"(proteasome core complex)|go:"GO:0005844"(polysome)|go:"GO:0010499"(proteasomal ubiquitin-independent protein catabolic process)|go:"GO:0016363"(nuclear matrix)|go:"GO:0019773"(proteasome core complex, alpha-subunit complex)|go:"GO:0030016"(myofibril)|go:"GO:0030017"(sarcomere)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0051059"(NF-kappaB binding)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051603"(proteolysis involved in cellular protein catabolic process)|interpro:IPR000426(Proteasome alpha-subunit, conserved site)|interpro:IPR001353(20S proteasome, A and B subunits)|interpro:IPR023332|interpro:IPR029055|interpro:IPR034642|rcsb pdb:6EPC|rcsb pdb:6EPD|rcsb pdb:6EPE|rcsb pdb:6EPF|rcsb pdb:6TU3|reactome:R-RNO-1169091|reactome:R-RNO-1234176|reactome:R-RNO-1236978|reactome:R-RNO-174084|reactome:R-RNO-174154|reactome:R-RNO-174178|reactome:R-RNO-174184|reactome:R-RNO-187577|reactome:R-RNO-195253|reactome:R-RNO-2467813|reactome:R-RNO-349425	-	-	-	caution:"The participant EBI-349571(P68370) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919386(Q7TP47) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920972(Q5XIP9) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-916419(P11980) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919578(Q8R491) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920554(Q5U3Z7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920647(Q5U2X8) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920585(Q7TP24) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-779677(P05426) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-915744(P02454) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|agonist:Insulin was shown to increase or decrease GLUT4 protein interactions in specific cases.|comment:"Insulin decreased GLUT4 interactions with the following proteins: Q9ER30 (Sarcosin), P09527 (Rab-7), O88960 (N-ethylmaleimide sensitive), P09456 (PKA I regulatory subunit), P27881 (Hexokinase type II), P07872 (Acyl-coenzyme A oxidase), Q6DGF1 (Isocitrate dehydrogenase), Q9EQX9 (Ubiquitin-conjugating), Q63446 (Polyubiquitin), P24268 (Cathepsin D), Q91XW0 (Heat shock protein 86), Q5FVH0 (unknown), P58405 (Striatin 3), Q62667 (Major vault protein), Q66H50 (unknown), Q09167 (splicing factor), Q9JHU5 (Arfaptin 1)."|comment:"Insulin increased GLUT4 interaction with the following proteins:Q9Z1P2 (R-actinin-1), P45592 (Cofilin), Q9QXQ0 (R-actinin-4), P26473 (ADP-ribosylation factor), P26437 (ADP-ribosylation factor),   Q7TNP1 (Basigin 2), Q6P6R2 (Dihydrolipoamide dehydrogenase),   P04797 (GAPDH), Q63081 (Protein disulfide isomerase), P29457 (47 kDa heat shock protein), Q9R1J8 (Leprecan), O88638 (Putative eps protein),   Q64375 (Synaptonemal complex)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:NDPK - Interactions involving proteins containing InterPro domain IPR001564, Nucleoside diphosphate kinase, core.	taxid:10116(rat-l6)|taxid:10116(Rattus norvegicus)	-	2006/02/15	2021/11/30	rogid:PbFY2lfrty8yw40Jq7ShR7xfuV410116	rogid:F+Kwr6rnDS3jD53gBGHDIn7HV/810116	intact-crc:44F3A2176D02515F|rigid:9RVm0UBcqQF4k06RGKO89Bg16Q8	false	myc tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P19357	uniprotkb:P60892	intact:EBI-915426|uniprotkb:P97900|ensembl:ENSRNOP00000023256	intact:EBI-917830|uniprotkb:P09329|uniprotkb:Q5M8A4|ensembl:ENSRNOP00000071101	psi-mi:glut4_rat(display_long)|uniprotkb:Glucose transporter type 4, insulin-responsive(gene name synonym)|uniprotkb:Slc2a4(gene name)|psi-mi:Slc2a4(display_short)|uniprotkb:Glut4(gene name synonym)	psi-mi:prps1_rat(display_long)|uniprotkb:Phosphoribosyl pyrophosphate synthase I(gene name synonym)|uniprotkb:Prps1(gene name)|psi-mi:Prps1(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Foster et al. (2006)	pubmed:16396496|mint:MINT-5218203	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-921030	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2711|refseq:NP_036883.1|refseq:XP_006246658.1|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007611"(learning or memory)|go:"GO:0007614"(short-term memory)|go:"GO:0007616"(long-term memory)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010021"(amylopectin biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031550"(positive regulation of brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044381"(glucose import in response to insulin stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046323"(glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0098694"(regulation of synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0098793"(presynapse)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002441("Glucose transporter, type 4 (GLUT4)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-189200|ensembl:ENSRNOG00000017226(gene)|ensembl:ENSRNOT00000023256(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)	rgd:61955|refseq:NP_001009694.1|refseq:NP_058939.1|refseq:XP_008762879.1|ensembl:ENSRNOG00000060262(gene)|ensembl:ENSRNOT00000078582(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0002189"(ribose phosphate diphosphokinase complex)|go:"GO:0004749"(ribose phosphate diphosphokinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0006015"(5-phosphoribose 1-diphosphate biosynthetic process)|go:"GO:0006144"(purine nucleobase metabolic process)|go:"GO:0006164"(purine nucleotide biosynthetic process)|go:"GO:0006167"(AMP biosynthetic process)|go:"GO:0007399"(nervous system development)|go:"GO:0009116"(nucleoside metabolic process)|go:"GO:0009165"(nucleotide biosynthetic process)|go:"GO:0016208"(AMP binding)|go:"GO:0016301"(kinase activity)|go:"GO:0019003"(GDP binding)|go:"GO:0019693"(ribose phosphate metabolic process)|go:"GO:0030246"(carbohydrate binding)|go:"GO:0031100"(animal organ regeneration)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034418"(urate biosynthetic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043531"(ADP binding)|go:"GO:0046101"(hypoxanthine biosynthetic process)|interpro:IPR000836(Phosphoribosyltransferase)|interpro:IPR000842(Phosphoribosyl pyrophosphate synthetase, conserved site)|interpro:IPR005946(Phosphoribosyl pyrophosphokinase)|interpro:IPR029057|interpro:IPR029099|interpro:IPR037515|reactome:R-RNO-73843	-	-	-	caution:"The participant EBI-349571(P68370) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919386(Q7TP47) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920972(Q5XIP9) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-916419(P11980) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919578(Q8R491) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920554(Q5U3Z7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920647(Q5U2X8) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920585(Q7TP24) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-779677(P05426) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-915744(P02454) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|agonist:Insulin was shown to increase or decrease GLUT4 protein interactions in specific cases.|comment:"Insulin decreased GLUT4 interactions with the following proteins: Q9ER30 (Sarcosin), P09527 (Rab-7), O88960 (N-ethylmaleimide sensitive), P09456 (PKA I regulatory subunit), P27881 (Hexokinase type II), P07872 (Acyl-coenzyme A oxidase), Q6DGF1 (Isocitrate dehydrogenase), Q9EQX9 (Ubiquitin-conjugating), Q63446 (Polyubiquitin), P24268 (Cathepsin D), Q91XW0 (Heat shock protein 86), Q5FVH0 (unknown), P58405 (Striatin 3), Q62667 (Major vault protein), Q66H50 (unknown), Q09167 (splicing factor), Q9JHU5 (Arfaptin 1)."|comment:"Insulin increased GLUT4 interaction with the following proteins:Q9Z1P2 (R-actinin-1), P45592 (Cofilin), Q9QXQ0 (R-actinin-4), P26473 (ADP-ribosylation factor), P26437 (ADP-ribosylation factor),   Q7TNP1 (Basigin 2), Q6P6R2 (Dihydrolipoamide dehydrogenase),   P04797 (GAPDH), Q63081 (Protein disulfide isomerase), P29457 (47 kDa heat shock protein), Q9R1J8 (Leprecan), O88638 (Putative eps protein),   Q64375 (Synaptonemal complex)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:NDPK - Interactions involving proteins containing InterPro domain IPR001564, Nucleoside diphosphate kinase, core.	taxid:10116(rat-l6)|taxid:10116(Rattus norvegicus)	-	2006/02/15	2021/11/30	rogid:PbFY2lfrty8yw40Jq7ShR7xfuV410116	rogid:+Hih2M7JLTsjEglauBlPj182h9M10116	intact-crc:44F3A2176D02515F|rigid:9RVm0UBcqQF4k06RGKO89Bg16Q8	false	myc tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P19357	uniprotkb:P60711	intact:EBI-915426|uniprotkb:P97900|ensembl:ENSRNOP00000023256	intact:EBI-349272|uniprotkb:Q64316|uniprotkb:P02570|uniprotkb:P70514|uniprotkb:P99021|uniprotkb:Q11211|ensembl:ENSRNOP00000044296	psi-mi:glut4_rat(display_long)|uniprotkb:Glucose transporter type 4, insulin-responsive(gene name synonym)|uniprotkb:Slc2a4(gene name)|psi-mi:Slc2a4(display_short)|uniprotkb:Glut4(gene name synonym)	psi-mi:actb_rat(display_long)|uniprotkb:Actb(gene name)|psi-mi:Actb(display_short)|uniprotkb:Beta-actin(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Foster et al. (2006)	pubmed:16396496|mint:MINT-5218203	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-921030	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2711|refseq:NP_036883.1|refseq:XP_006246658.1|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007611"(learning or memory)|go:"GO:0007614"(short-term memory)|go:"GO:0007616"(long-term memory)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010021"(amylopectin biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031550"(positive regulation of brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044381"(glucose import in response to insulin stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046323"(glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0098694"(regulation of synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0098793"(presynapse)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002441("Glucose transporter, type 4 (GLUT4)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-189200|ensembl:ENSRNOG00000017226(gene)|ensembl:ENSRNOT00000023256(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)	rgd:628837|refseq:NP_112406.1|ensembl:ENSRNOG00000034254(gene)|ensembl:ENSRNOT00000042459(transcript)|go:"GO:0000079"(regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0001725"(stress fiber)|go:"GO:0001738"(morphogenesis of a polarized epithelium)|go:"GO:0002102"(podosome)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005884"(actin filament)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005912"(adherens junction)|go:"GO:0005925"(focal adhesion)|go:"GO:0007163"(establishment or maintenance of cell polarity)|go:"GO:0007409"(axonogenesis)|go:"GO:0007623"(circadian rhythm)|go:"GO:0009612"(response to mechanical stimulus)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0019894"(kinesin binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0022898"(regulation of transmembrane transporter activity)|go:"GO:0030027"(lamellipodium)|go:"GO:0030424"(axon)|go:"GO:0030863"(cortical cytoskeleton)|go:"GO:0030957"(Tat protein binding)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034333"(adherens junction assembly)|go:"GO:0035902"(response to immobilization stress)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042802"(identical protein binding)|go:"GO:0043296"(apical junction complex)|go:"GO:0044305"(calyx of Held)|go:"GO:0045121"(membrane raft)|go:"GO:0045176"(apical protein localization)|go:"GO:0045202"(synapse)|go:"GO:0048488"(synaptic vesicle endocytosis)|go:"GO:0048870"(cell motility)|go:"GO:0050998"(nitric-oxide synthase binding)|go:"GO:0051621"(regulation of norepinephrine uptake)|go:"GO:0060041"(retina development in camera-type eye)|go:"GO:0070160"(tight junction)|go:"GO:0071257"(cellular response to electrical stimulus)|go:"GO:0071896"(protein localization to adherens junction)|go:"GO:0072749"(cellular response to cytochalasin B)|go:"GO:0097433"(dense body)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098871"(postsynaptic actin cytoskeleton)|go:"GO:0035267"(NuA4 histone acetyltransferase complex)|go:"GO:0098973"(structural constituent of postsynaptic actin cytoskeleton)|reactome:R-RNO-190873|reactome:R-RNO-196025|go:"GO:0098974"(postsynaptic actin cytoskeleton organization)|reactome:R-RNO-2029482|reactome:R-RNO-3928662|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0150111"(regulation of transepithelial transport)|reactome:R-RNO-418990|reactome:R-RNO-437239|go:"GO:1903076"(regulation of protein localization to plasma membrane)|reactome:R-RNO-4420097|reactome:R-RNO-445095|reactome:R-RNO-446353|reactome:R-RNO-5250924|reactome:R-RNO-5626467|reactome:R-RNO-5663213|reactome:R-RNO-5663220|reactome:R-RNO-5674135|reactome:R-RNO-5689603|reactome:R-RNO-5696394|reactome:R-RNO-8856828|reactome:R-RNO-9035034|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR004000(Actin/actin-like)|interpro:IPR004001(Actin, conserved site)|interpro:IPR020902|interpro:IPR043129|mint:P60711	-	-	-	caution:"The participant EBI-349571(P68370) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919386(Q7TP47) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920972(Q5XIP9) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-916419(P11980) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919578(Q8R491) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920554(Q5U3Z7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920647(Q5U2X8) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920585(Q7TP24) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-779677(P05426) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-915744(P02454) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|agonist:Insulin was shown to increase or decrease GLUT4 protein interactions in specific cases.|comment:"Insulin decreased GLUT4 interactions with the following proteins: Q9ER30 (Sarcosin), P09527 (Rab-7), O88960 (N-ethylmaleimide sensitive), P09456 (PKA I regulatory subunit), P27881 (Hexokinase type II), P07872 (Acyl-coenzyme A oxidase), Q6DGF1 (Isocitrate dehydrogenase), Q9EQX9 (Ubiquitin-conjugating), Q63446 (Polyubiquitin), P24268 (Cathepsin D), Q91XW0 (Heat shock protein 86), Q5FVH0 (unknown), P58405 (Striatin 3), Q62667 (Major vault protein), Q66H50 (unknown), Q09167 (splicing factor), Q9JHU5 (Arfaptin 1)."|comment:"Insulin increased GLUT4 interaction with the following proteins:Q9Z1P2 (R-actinin-1), P45592 (Cofilin), Q9QXQ0 (R-actinin-4), P26473 (ADP-ribosylation factor), P26437 (ADP-ribosylation factor),   Q7TNP1 (Basigin 2), Q6P6R2 (Dihydrolipoamide dehydrogenase),   P04797 (GAPDH), Q63081 (Protein disulfide isomerase), P29457 (47 kDa heat shock protein), Q9R1J8 (Leprecan), O88638 (Putative eps protein),   Q64375 (Synaptonemal complex)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:NDPK - Interactions involving proteins containing InterPro domain IPR001564, Nucleoside diphosphate kinase, core.	taxid:10116(rat-l6)|taxid:10116(Rattus norvegicus)	-	2006/02/15	2021/11/30	rogid:PbFY2lfrty8yw40Jq7ShR7xfuV410116	rogid:Hoge1B8Pn56kvbNTpkSLsQuHwRc10116	intact-crc:44F3A2176D02515F|rigid:9RVm0UBcqQF4k06RGKO89Bg16Q8	false	myc tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P19357	uniprotkb:P60192	intact:EBI-915426|uniprotkb:P97900|ensembl:ENSRNOP00000023256	intact:EBI-917825|ensembl:ENSRNOP00000018830	psi-mi:glut4_rat(display_long)|uniprotkb:Glucose transporter type 4, insulin-responsive(gene name synonym)|uniprotkb:Slc2a4(gene name)|psi-mi:Slc2a4(display_short)|uniprotkb:Glut4(gene name synonym)	psi-mi:snapn_rat(display_long)|uniprotkb:Snapap(gene name synonym)|uniprotkb:Synaptosomal-associated protein 25-binding protein(gene name synonym)|uniprotkb:Snapin(gene name)|psi-mi:Snapin(display_short)|uniprotkb:Snap25bp(gene name synonym)|uniprotkb:Biogenesis of lysosome-related organelles complex 1 subunit 7(gene name synonym)|uniprotkb:Bloc1s7(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Foster et al. (2006)	pubmed:16396496|mint:MINT-5218203	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-921030	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2711|refseq:NP_036883.1|refseq:XP_006246658.1|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007611"(learning or memory)|go:"GO:0007614"(short-term memory)|go:"GO:0007616"(long-term memory)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010021"(amylopectin biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031550"(positive regulation of brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044381"(glucose import in response to insulin stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046323"(glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0098694"(regulation of synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0098793"(presynapse)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002441("Glucose transporter, type 4 (GLUT4)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-189200|ensembl:ENSRNOG00000017226(gene)|ensembl:ENSRNOT00000023256(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)	rgd:1560377|refseq:NP_001164047.1|ensembl:ENSRNOG00000013356(gene)|ensembl:ENSRNOT00000018830(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0000149"(SNARE binding)|go:"GO:0001669"(acrosomal vesicle)|go:"GO:0002177"(manchette)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005829"(cytosol)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0007040"(lysosome organization)|go:"GO:0007042"(lysosomal lumen acidification)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008089"(anterograde axonal transport)|go:"GO:0008090"(retrograde axonal transport)|go:"GO:0008333"(endosome to lysosome transport)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0016079"(synaptic vesicle exocytosis)|go:"GO:0016188"(synaptic vesicle maturation)|go:"GO:0030141"(secretory granule)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0031083"(BLOC-1 complex)|go:"GO:0031175"(neuron projection development)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031629"(synaptic vesicle fusion to presynaptic active zone membrane)|go:"GO:0032418"(lysosome localization)|go:"GO:0034629"|go:"GO:0043393"(regulation of protein binding)|go:"GO:0045202"(synapse)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048489"(synaptic vesicle transport)|go:"GO:0048490"(anterograde synaptic vesicle transport)|go:"GO:0051604"(protein maturation)|go:"GO:0072553"(terminal button organization)|go:"GO:0097352"(autophagosome maturation)|go:"GO:0099078"(BORC complex)|go:"GO:1902774"(late endosome to lysosome transport)|go:"GO:1904115"(axon cytoplasm)|go:"GO:2000300"(regulation of synaptic vesicle exocytosis)|interpro:IPR017246(Snapin)|interpro:IPR028119|mint:P60192|reactome:R-RNO-432722	-	-	-	caution:"The participant EBI-349571(P68370) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919386(Q7TP47) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920972(Q5XIP9) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-916419(P11980) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919578(Q8R491) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920554(Q5U3Z7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920647(Q5U2X8) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920585(Q7TP24) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-779677(P05426) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-915744(P02454) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|agonist:Insulin was shown to increase or decrease GLUT4 protein interactions in specific cases.|comment:"Insulin decreased GLUT4 interactions with the following proteins: Q9ER30 (Sarcosin), P09527 (Rab-7), O88960 (N-ethylmaleimide sensitive), P09456 (PKA I regulatory subunit), P27881 (Hexokinase type II), P07872 (Acyl-coenzyme A oxidase), Q6DGF1 (Isocitrate dehydrogenase), Q9EQX9 (Ubiquitin-conjugating), Q63446 (Polyubiquitin), P24268 (Cathepsin D), Q91XW0 (Heat shock protein 86), Q5FVH0 (unknown), P58405 (Striatin 3), Q62667 (Major vault protein), Q66H50 (unknown), Q09167 (splicing factor), Q9JHU5 (Arfaptin 1)."|comment:"Insulin increased GLUT4 interaction with the following proteins:Q9Z1P2 (R-actinin-1), P45592 (Cofilin), Q9QXQ0 (R-actinin-4), P26473 (ADP-ribosylation factor), P26437 (ADP-ribosylation factor),   Q7TNP1 (Basigin 2), Q6P6R2 (Dihydrolipoamide dehydrogenase),   P04797 (GAPDH), Q63081 (Protein disulfide isomerase), P29457 (47 kDa heat shock protein), Q9R1J8 (Leprecan), O88638 (Putative eps protein),   Q64375 (Synaptonemal complex)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:NDPK - Interactions involving proteins containing InterPro domain IPR001564, Nucleoside diphosphate kinase, core.	taxid:10116(rat-l6)|taxid:10116(Rattus norvegicus)	-	2006/02/15	2021/11/30	rogid:PbFY2lfrty8yw40Jq7ShR7xfuV410116	rogid:L66mKyBsv3V0+K6AhcHvc540uX810116	intact-crc:44F3A2176D02515F|rigid:9RVm0UBcqQF4k06RGKO89Bg16Q8	false	myc tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P19357	uniprotkb:P60123	intact:EBI-915426|uniprotkb:P97900|ensembl:ENSRNOP00000023256	intact:EBI-917815|uniprotkb:O35753|ensembl:ENSRNOP00000018339|ensembl:ENSRNOP00000075190	psi-mi:glut4_rat(display_long)|uniprotkb:Glucose transporter type 4, insulin-responsive(gene name synonym)|uniprotkb:Slc2a4(gene name)|psi-mi:Slc2a4(display_short)|uniprotkb:Glut4(gene name synonym)	psi-mi:ruvb1_rat(display_long)|uniprotkb:49 kDa TATA box-binding protein-interacting protein(gene name synonym)|uniprotkb:TIP49a(gene name synonym)|uniprotkb:Pontin 52(gene name synonym)|uniprotkb:DNA helicase p50(gene name synonym)|uniprotkb:Ruvbl1(gene name)|psi-mi:Ruvbl1(display_short)|uniprotkb:Tip49(gene name synonym)|uniprotkb:Tip49a(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Foster et al. (2006)	pubmed:16396496|mint:MINT-5218203	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-921030	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2711|refseq:NP_036883.1|refseq:XP_006246658.1|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007611"(learning or memory)|go:"GO:0007614"(short-term memory)|go:"GO:0007616"(long-term memory)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010021"(amylopectin biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031550"(positive regulation of brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044381"(glucose import in response to insulin stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046323"(glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0098694"(regulation of synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0098793"(presynapse)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002441("Glucose transporter, type 4 (GLUT4)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-189200|ensembl:ENSRNOG00000017226(gene)|ensembl:ENSRNOT00000023256(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)	rgd:68373|refseq:NP_671706.1|refseq:XP_006236927.1|ensembl:ENSRNOG00000013195(gene)|ensembl:ENSRNOT00000018339(transcript)|ensembl:ENSRNOT00000090875(transcript)|go:"GO:0000492"(box C/D snoRNP assembly)|go:"GO:0000812"(Swr1 complex)|go:"GO:0001094"(TFIID-class transcription factor complex binding)|go:"GO:0003678"(DNA helicase activity)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0006281"(DNA repair)|go:"GO:0006310"(DNA recombination)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007049"(cell cycle)|go:"GO:0010756"(positive regulation of plasminogen activation)|go:"GO:0016363"(nuclear matrix)|go:"GO:0016573"(histone acetylation)|go:"GO:0017025"(TBP-class protein binding)|go:"GO:0031011"(Ino80 complex)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035267"(NuA4 histone acetyltransferase complex)|go:"GO:0040008"(regulation of growth)|go:"GO:0043138"(3'-5' DNA helicase activity)|go:"GO:0043139"(5'-3' DNA helicase activity)|go:"GO:0043531"(ADP binding)|go:"GO:0043967"(histone H4 acetylation)|go:"GO:0043968"(histone H2A acetylation)|go:"GO:0051117"(ATPase binding)|go:"GO:0051301"(cell division)|go:"GO:0071339"(MLL1 complex)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0097255"(R2TP complex)|go:"GO:0120293"(dynein axonemal particle)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1990904"(ribonucleoprotein complex)|go:"GO:2000269"(regulation of fibroblast apoptotic process)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR010339(TIP49, C-terminal)|interpro:IPR027417|interpro:IPR037938|interpro:IPR041048|mint:P60123|reactome:R-RNO-5689603|reactome:R-RNO-5689880|reactome:R-RNO-5696394|reactome:R-RNO-606279|interpro:IPR027238	-	-	-	caution:"The participant EBI-349571(P68370) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919386(Q7TP47) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920972(Q5XIP9) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-916419(P11980) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919578(Q8R491) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920554(Q5U3Z7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920647(Q5U2X8) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920585(Q7TP24) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-779677(P05426) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-915744(P02454) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|agonist:Insulin was shown to increase or decrease GLUT4 protein interactions in specific cases.|comment:"Insulin decreased GLUT4 interactions with the following proteins: Q9ER30 (Sarcosin), P09527 (Rab-7), O88960 (N-ethylmaleimide sensitive), P09456 (PKA I regulatory subunit), P27881 (Hexokinase type II), P07872 (Acyl-coenzyme A oxidase), Q6DGF1 (Isocitrate dehydrogenase), Q9EQX9 (Ubiquitin-conjugating), Q63446 (Polyubiquitin), P24268 (Cathepsin D), Q91XW0 (Heat shock protein 86), Q5FVH0 (unknown), P58405 (Striatin 3), Q62667 (Major vault protein), Q66H50 (unknown), Q09167 (splicing factor), Q9JHU5 (Arfaptin 1)."|comment:"Insulin increased GLUT4 interaction with the following proteins:Q9Z1P2 (R-actinin-1), P45592 (Cofilin), Q9QXQ0 (R-actinin-4), P26473 (ADP-ribosylation factor), P26437 (ADP-ribosylation factor),   Q7TNP1 (Basigin 2), Q6P6R2 (Dihydrolipoamide dehydrogenase),   P04797 (GAPDH), Q63081 (Protein disulfide isomerase), P29457 (47 kDa heat shock protein), Q9R1J8 (Leprecan), O88638 (Putative eps protein),   Q64375 (Synaptonemal complex)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:NDPK - Interactions involving proteins containing InterPro domain IPR001564, Nucleoside diphosphate kinase, core.	taxid:10116(rat-l6)|taxid:10116(Rattus norvegicus)	-	2006/02/15	2021/11/30	rogid:PbFY2lfrty8yw40Jq7ShR7xfuV410116	rogid:fZiQ7AurvKII0LYc+haBswAXfZ410116	intact-crc:44F3A2176D02515F|rigid:9RVm0UBcqQF4k06RGKO89Bg16Q8	false	myc tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P19357	uniprotkb:P58405	intact:EBI-915426|uniprotkb:P97900|ensembl:ENSRNOP00000023256	intact:EBI-917806|ensembl:ENSRNOP00000074395	psi-mi:glut4_rat(display_long)|uniprotkb:Glucose transporter type 4, insulin-responsive(gene name synonym)|uniprotkb:Slc2a4(gene name)|psi-mi:Slc2a4(display_short)|uniprotkb:Glut4(gene name synonym)	psi-mi:strn3_rat(display_long)|uniprotkb:Cell cycle autoantigen SG2NA(gene name synonym)|uniprotkb:S/G2 antigen(gene name synonym)|uniprotkb:Strn3(gene name)|psi-mi:Strn3(display_short)|uniprotkb:Gs2na(gene name synonym)|uniprotkb:Sg2na(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Foster et al. (2006)	pubmed:16396496|mint:MINT-5218203	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-921030	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2711|refseq:NP_036883.1|refseq:XP_006246658.1|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007611"(learning or memory)|go:"GO:0007614"(short-term memory)|go:"GO:0007616"(long-term memory)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010021"(amylopectin biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031550"(positive regulation of brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044381"(glucose import in response to insulin stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046323"(glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0098694"(regulation of synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0098793"(presynapse)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002441("Glucose transporter, type 4 (GLUT4)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-189200|ensembl:ENSRNOG00000017226(gene)|ensembl:ENSRNOT00000023256(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)	refseq:NP_001025068.1|rgd:621827|ensembl:ENSRNOG00000060335(gene)|ensembl:ENSRNOT00000077578(transcript)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0030425"(dendrite)|go:"GO:0031267"(small GTPase binding)|go:"GO:0032355"(response to estradiol)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033147"(negative regulation of intracellular estrogen receptor signaling pathway)|go:"GO:0043025"(neuronal cell body)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0051721"(protein phosphatase 2A binding)|go:"GO:0070016"(armadillo repeat domain binding)|go:"GO:0090443"(FAR/SIN/STRIPAK complex)|interpro:IPR001680(WD40 repeat)|interpro:IPR013258(Striatin, N-terminal)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR020472|interpro:IPR036322	-	-	-	caution:"The participant EBI-349571(P68370) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919386(Q7TP47) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920972(Q5XIP9) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-916419(P11980) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919578(Q8R491) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920554(Q5U3Z7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920647(Q5U2X8) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920585(Q7TP24) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-779677(P05426) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-915744(P02454) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|agonist:Insulin was shown to increase or decrease GLUT4 protein interactions in specific cases.|comment:"Insulin decreased GLUT4 interactions with the following proteins: Q9ER30 (Sarcosin), P09527 (Rab-7), O88960 (N-ethylmaleimide sensitive), P09456 (PKA I regulatory subunit), P27881 (Hexokinase type II), P07872 (Acyl-coenzyme A oxidase), Q6DGF1 (Isocitrate dehydrogenase), Q9EQX9 (Ubiquitin-conjugating), Q63446 (Polyubiquitin), P24268 (Cathepsin D), Q91XW0 (Heat shock protein 86), Q5FVH0 (unknown), P58405 (Striatin 3), Q62667 (Major vault protein), Q66H50 (unknown), Q09167 (splicing factor), Q9JHU5 (Arfaptin 1)."|comment:"Insulin increased GLUT4 interaction with the following proteins:Q9Z1P2 (R-actinin-1), P45592 (Cofilin), Q9QXQ0 (R-actinin-4), P26473 (ADP-ribosylation factor), P26437 (ADP-ribosylation factor),   Q7TNP1 (Basigin 2), Q6P6R2 (Dihydrolipoamide dehydrogenase),   P04797 (GAPDH), Q63081 (Protein disulfide isomerase), P29457 (47 kDa heat shock protein), Q9R1J8 (Leprecan), O88638 (Putative eps protein),   Q64375 (Synaptonemal complex)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:NDPK - Interactions involving proteins containing InterPro domain IPR001564, Nucleoside diphosphate kinase, core.	taxid:10116(rat-l6)|taxid:10116(Rattus norvegicus)	-	2006/02/15	2021/11/30	rogid:PbFY2lfrty8yw40Jq7ShR7xfuV410116	rogid:p/hfxJZTgDarMIs7JL1qctDh8Dk10116	intact-crc:44F3A2176D02515F|rigid:9RVm0UBcqQF4k06RGKO89Bg16Q8	false	myc tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P19357	uniprotkb:P55161	intact:EBI-915426|uniprotkb:P97900|ensembl:ENSRNOP00000023256	intact:EBI-917798	psi-mi:glut4_rat(display_long)|uniprotkb:Glucose transporter type 4, insulin-responsive(gene name synonym)|uniprotkb:Slc2a4(gene name)|psi-mi:Slc2a4(display_short)|uniprotkb:Glut4(gene name synonym)	psi-mi:nckp1_rat(display_long)|uniprotkb:p125Nap1(gene name synonym)|uniprotkb:Membrane-associated protein HEM-2(gene name synonym)|uniprotkb:Nckap1(gene name)|psi-mi:Nckap1(display_short)|uniprotkb:Hem2(gene name synonym)|uniprotkb:Nap1(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Foster et al. (2006)	pubmed:16396496|mint:MINT-5218203	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-921030	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2711|refseq:NP_036883.1|refseq:XP_006246658.1|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007611"(learning or memory)|go:"GO:0007614"(short-term memory)|go:"GO:0007616"(long-term memory)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010021"(amylopectin biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031550"(positive regulation of brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044381"(glucose import in response to insulin stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046323"(glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0098694"(regulation of synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0098793"(presynapse)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002441("Glucose transporter, type 4 (GLUT4)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-189200|ensembl:ENSRNOG00000017226(gene)|ensembl:ENSRNOT00000023256(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)	interpro:IPR019137|rgd:61939|refseq:NP_113806.1|reactome:R-RNO-9013149|reactome:R-RNO-9013404|reactome:R-RNO-9013423|reactome:R-RNO-2029482|reactome:R-RNO-4420097|reactome:R-RNO-5663213|go:"GO:0010172"(embryonic body morphogenesis)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016477"(cell migration)|go:"GO:0016601"(Rac protein signal transduction)|go:"GO:0030027"(lamellipodium)|go:"GO:0030031"(cell projection assembly)|go:"GO:0030032"(lamellipodium assembly)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0030866"(cortical actin cytoskeleton organization)|go:"GO:0030903"(notochord development)|go:"GO:0030950"(establishment or maintenance of actin cytoskeleton polarity)|go:"GO:0031209"(SCAR complex)|go:"GO:0031258"(lamellipodium membrane)|go:"GO:0031941"(filamentous actin)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0035050"(embryonic heart tube development)|go:"GO:0042074"(cell migration involved in gastrulation)|go:"GO:0045175"(basal protein localization)|go:"GO:0045176"(apical protein localization)|go:"GO:0048339"(paraxial mesoderm development)|go:"GO:0048340"(paraxial mesoderm morphogenesis)|go:"GO:0048570"(notochord morphogenesis)|go:"GO:0048617"(embryonic foregut morphogenesis)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0050821"(protein stabilization)|go:"GO:0098794"(postsynapse)|go:"GO:2000601"(positive regulation of Arp2/3 complex-mediated actin nucleation)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001726"(ruffle)|go:"GO:0001756"(somitogenesis)|go:"GO:0001843"(neural tube closure)|go:"GO:0007354"(zygotic determination of anterior/posterior axis, embryo)|go:"GO:0007492"(endoderm development)|go:"GO:0008078"(mesodermal cell migration)	-	-	-	caution:"The participant EBI-349571(P68370) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919386(Q7TP47) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920972(Q5XIP9) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-916419(P11980) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919578(Q8R491) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920554(Q5U3Z7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920647(Q5U2X8) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920585(Q7TP24) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-779677(P05426) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-915744(P02454) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|agonist:Insulin was shown to increase or decrease GLUT4 protein interactions in specific cases.|comment:"Insulin decreased GLUT4 interactions with the following proteins: Q9ER30 (Sarcosin), P09527 (Rab-7), O88960 (N-ethylmaleimide sensitive), P09456 (PKA I regulatory subunit), P27881 (Hexokinase type II), P07872 (Acyl-coenzyme A oxidase), Q6DGF1 (Isocitrate dehydrogenase), Q9EQX9 (Ubiquitin-conjugating), Q63446 (Polyubiquitin), P24268 (Cathepsin D), Q91XW0 (Heat shock protein 86), Q5FVH0 (unknown), P58405 (Striatin 3), Q62667 (Major vault protein), Q66H50 (unknown), Q09167 (splicing factor), Q9JHU5 (Arfaptin 1)."|comment:"Insulin increased GLUT4 interaction with the following proteins:Q9Z1P2 (R-actinin-1), P45592 (Cofilin), Q9QXQ0 (R-actinin-4), P26473 (ADP-ribosylation factor), P26437 (ADP-ribosylation factor),   Q7TNP1 (Basigin 2), Q6P6R2 (Dihydrolipoamide dehydrogenase),   P04797 (GAPDH), Q63081 (Protein disulfide isomerase), P29457 (47 kDa heat shock protein), Q9R1J8 (Leprecan), O88638 (Putative eps protein),   Q64375 (Synaptonemal complex)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:NDPK - Interactions involving proteins containing InterPro domain IPR001564, Nucleoside diphosphate kinase, core.	taxid:10116(rat-l6)|taxid:10116(Rattus norvegicus)	-	2006/02/15	2021/11/30	rogid:PbFY2lfrty8yw40Jq7ShR7xfuV410116	rogid:STo4DC5yxeuoNC9SSGUJLVMmK4I10116	intact-crc:44F3A2176D02515F|rigid:9RVm0UBcqQF4k06RGKO89Bg16Q8	false	myc tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P19357	uniprotkb:P54921	intact:EBI-915426|uniprotkb:P97900|ensembl:ENSRNOP00000023256	intact:EBI-917790|ensembl:ENSRNOP00000002044	psi-mi:glut4_rat(display_long)|uniprotkb:Glucose transporter type 4, insulin-responsive(gene name synonym)|uniprotkb:Slc2a4(gene name)|psi-mi:Slc2a4(display_short)|uniprotkb:Glut4(gene name synonym)	psi-mi:snaa_rat(display_long)|uniprotkb:N-ethylmaleimide-sensitive factor attachment protein alpha(gene name synonym)|uniprotkb:Napa(gene name)|psi-mi:Napa(display_short)|uniprotkb:Snap(gene name synonym)|uniprotkb:Snapa(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Foster et al. (2006)	pubmed:16396496|mint:MINT-5218203	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-921030	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2711|refseq:NP_036883.1|refseq:XP_006246658.1|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007611"(learning or memory)|go:"GO:0007614"(short-term memory)|go:"GO:0007616"(long-term memory)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010021"(amylopectin biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031550"(positive regulation of brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044381"(glucose import in response to insulin stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046323"(glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0098694"(regulation of synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0098793"(presynapse)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002441("Glucose transporter, type 4 (GLUT4)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-189200|ensembl:ENSRNOG00000017226(gene)|ensembl:ENSRNOT00000023256(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)	rgd:620855|refseq:NP_542152.1|dip:DIP-37030N|ensembl:ENSRNOG00000001494(gene)|ensembl:ENSRNOT00000002044(transcript)|go:"GO:0000149"(SNARE binding)|go:"GO:0005483"(soluble NSF attachment protein activity)|go:"GO:0005774"(vacuolar membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0007420"(brain development)|go:"GO:0010807"(regulation of synaptic vesicle priming)|go:"GO:0016082"(synaptic vesicle priming)|go:"GO:0019905"(syntaxin binding)|go:"GO:0030182"(neuron differentiation)|go:"GO:0031201"(SNARE complex)|go:"GO:0032781"(positive regulation of ATP-dependent activity)|go:"GO:0032984"(protein-containing complex disassembly)|go:"GO:0035249"(synaptic transmission, glutamatergic)|go:"GO:0035494"(SNARE complex disassembly)|go:"GO:0043195"(terminal bouton)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045176"(apical protein localization)|go:"GO:0061025"(membrane fusion)|go:"GO:0070044"(synaptobrevin 2-SNAP-25-syntaxin-1a complex)|go:"GO:0098793"(presynapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098978"(glutamatergic synapse)|interpro:IPR000744(NSF attachment protein)|interpro:IPR011990(Tetratricopeptide-like helical)|mint:P54921|rcsb pdb:3J96|rcsb pdb:3J97|rcsb pdb:3J98|rcsb pdb:3J99|rcsb pdb:6MDM|rcsb pdb:6MDN|reactome:R-RNO-204005|reactome:R-RNO-432722|reactome:R-RNO-6807878|reactome:R-RNO-6811434|reactome:R-RNO-6811438|reactome:R-RNO-6811440	-	-	-	caution:"The participant EBI-349571(P68370) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919386(Q7TP47) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920972(Q5XIP9) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-916419(P11980) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919578(Q8R491) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920554(Q5U3Z7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920647(Q5U2X8) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920585(Q7TP24) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-779677(P05426) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-915744(P02454) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|agonist:Insulin was shown to increase or decrease GLUT4 protein interactions in specific cases.|comment:"Insulin decreased GLUT4 interactions with the following proteins: Q9ER30 (Sarcosin), P09527 (Rab-7), O88960 (N-ethylmaleimide sensitive), P09456 (PKA I regulatory subunit), P27881 (Hexokinase type II), P07872 (Acyl-coenzyme A oxidase), Q6DGF1 (Isocitrate dehydrogenase), Q9EQX9 (Ubiquitin-conjugating), Q63446 (Polyubiquitin), P24268 (Cathepsin D), Q91XW0 (Heat shock protein 86), Q5FVH0 (unknown), P58405 (Striatin 3), Q62667 (Major vault protein), Q66H50 (unknown), Q09167 (splicing factor), Q9JHU5 (Arfaptin 1)."|comment:"Insulin increased GLUT4 interaction with the following proteins:Q9Z1P2 (R-actinin-1), P45592 (Cofilin), Q9QXQ0 (R-actinin-4), P26473 (ADP-ribosylation factor), P26437 (ADP-ribosylation factor),   Q7TNP1 (Basigin 2), Q6P6R2 (Dihydrolipoamide dehydrogenase),   P04797 (GAPDH), Q63081 (Protein disulfide isomerase), P29457 (47 kDa heat shock protein), Q9R1J8 (Leprecan), O88638 (Putative eps protein),   Q64375 (Synaptonemal complex)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:NDPK - Interactions involving proteins containing InterPro domain IPR001564, Nucleoside diphosphate kinase, core.	taxid:10116(rat-l6)|taxid:10116(Rattus norvegicus)	-	2006/02/15	2021/11/30	rogid:PbFY2lfrty8yw40Jq7ShR7xfuV410116	rogid:+Lm6fLpvZFjClv3xfc066b0H2Gc10116	intact-crc:44F3A2176D02515F|rigid:9RVm0UBcqQF4k06RGKO89Bg16Q8	false	myc tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P19357	uniprotkb:P54311	intact:EBI-915426|uniprotkb:P97900|ensembl:ENSRNOP00000023256	intact:EBI-917779|uniprotkb:Q6Q8B1|uniprotkb:Q9QWG8|ensembl:ENSRNOP00000044340	psi-mi:glut4_rat(display_long)|uniprotkb:Glucose transporter type 4, insulin-responsive(gene name synonym)|uniprotkb:Slc2a4(gene name)|psi-mi:Slc2a4(display_short)|uniprotkb:Glut4(gene name synonym)	psi-mi:gbb1_rat(display_long)|uniprotkb:Transducin beta chain 1(gene name synonym)|uniprotkb:Gnb1(gene name)|psi-mi:Gnb1(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Foster et al. (2006)	pubmed:16396496|mint:MINT-5218203	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-921030	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2711|refseq:NP_036883.1|refseq:XP_006246658.1|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007611"(learning or memory)|go:"GO:0007614"(short-term memory)|go:"GO:0007616"(long-term memory)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010021"(amylopectin biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031550"(positive regulation of brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044381"(glucose import in response to insulin stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046323"(glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0098694"(regulation of synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0098793"(presynapse)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002441("Glucose transporter, type 4 (GLUT4)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-189200|ensembl:ENSRNOG00000017226(gene)|ensembl:ENSRNOT00000023256(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)	rgd:2718|refseq:NP_112249.2|go:"GO:0001750"(photoreceptor outer segment)|go:"GO:0001917"(photoreceptor inner segment)|go:"GO:0003924"(GTPase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005834"(heterotrimeric G-protein complex)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007200"(phospholipase C-activating G protein-coupled receptor signaling pathway)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0008283"(cell population proliferation)|go:"GO:0010659"(cardiac muscle cell apoptotic process)|go:"GO:0030425"(dendrite)|go:"GO:0030507"(spectrin binding)|go:"GO:0031682"(G-protein gamma-subunit binding)|go:"GO:0042622"(photoreceptor outer segment membrane)|go:"GO:0044297"(cell body)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0047391"(alkylglycerophosphoethanolamine phosphodiesterase activity)|go:"GO:0050909"(sensory perception of taste)|ensembl:ENSRNOT00000041789(transcript)|ensembl:ENSRNOG00000016638(gene)|refseq:XP_008762557.1|refseq:XP_006239579.1|refseq:XP_017448634.1|refseq:XP_017448635.1|refseq:XP_017448636.1|refseq:XP_017448637.1|refseq:XP_017448638.1|dip:DIP-37029N|go:"GO:0051020"(GTPase binding)|go:"GO:0060041"(retina development in camera-type eye)|go:"GO:0071456"(cellular response to hypoxia)|interpro:IPR001632(G-protein, beta subunit)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR016346(Guanine nucleotide-binding protein, beta subunit)|interpro:IPR019775|interpro:IPR020472|interpro:IPR036322|mint:P54311|rcsb pdb:3SN6|rcsb pdb:5TDH|rcsb pdb:5VAI|rcsb pdb:6CMO|rcsb pdb:6LPB|rcsb pdb:6NBF|rcsb pdb:6NBH|rcsb pdb:6NBI|rcsb pdb:6WWZ|rcsb pdb:7BW0|rcsb pdb:7CZ5|rcsb pdb:7D3S|rcsb pdb:7LJC|rcsb pdb:7LJD|rcsb pdb:7MBX|rcsb pdb:7MBY|reactome:R-RNO-1296041|reactome:R-RNO-202040|reactome:R-RNO-2485179|reactome:R-RNO-381676|reactome:R-RNO-381753|reactome:R-RNO-392170|reactome:R-RNO-392451|reactome:R-RNO-400042|reactome:R-RNO-4086398|reactome:R-RNO-416476|reactome:R-RNO-418594|reactome:R-RNO-418597|reactome:R-RNO-420092|reactome:R-RNO-428930|reactome:R-RNO-432040|reactome:R-RNO-456926|reactome:R-RNO-6814122|reactome:R-RNO-8964616|reactome:R-RNO-997272	-	-	-	caution:"The participant EBI-349571(P68370) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919386(Q7TP47) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920972(Q5XIP9) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-916419(P11980) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919578(Q8R491) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920554(Q5U3Z7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920647(Q5U2X8) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920585(Q7TP24) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-779677(P05426) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-915744(P02454) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|agonist:Insulin was shown to increase or decrease GLUT4 protein interactions in specific cases.|comment:"Insulin decreased GLUT4 interactions with the following proteins: Q9ER30 (Sarcosin), P09527 (Rab-7), O88960 (N-ethylmaleimide sensitive), P09456 (PKA I regulatory subunit), P27881 (Hexokinase type II), P07872 (Acyl-coenzyme A oxidase), Q6DGF1 (Isocitrate dehydrogenase), Q9EQX9 (Ubiquitin-conjugating), Q63446 (Polyubiquitin), P24268 (Cathepsin D), Q91XW0 (Heat shock protein 86), Q5FVH0 (unknown), P58405 (Striatin 3), Q62667 (Major vault protein), Q66H50 (unknown), Q09167 (splicing factor), Q9JHU5 (Arfaptin 1)."|comment:"Insulin increased GLUT4 interaction with the following proteins:Q9Z1P2 (R-actinin-1), P45592 (Cofilin), Q9QXQ0 (R-actinin-4), P26473 (ADP-ribosylation factor), P26437 (ADP-ribosylation factor),   Q7TNP1 (Basigin 2), Q6P6R2 (Dihydrolipoamide dehydrogenase),   P04797 (GAPDH), Q63081 (Protein disulfide isomerase), P29457 (47 kDa heat shock protein), Q9R1J8 (Leprecan), O88638 (Putative eps protein),   Q64375 (Synaptonemal complex)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:NDPK - Interactions involving proteins containing InterPro domain IPR001564, Nucleoside diphosphate kinase, core.	taxid:10116(rat-l6)|taxid:10116(Rattus norvegicus)	-	2006/02/15	2021/11/30	rogid:PbFY2lfrty8yw40Jq7ShR7xfuV410116	rogid:zP/G70MXiSQpzbyyWFTWrJFQENk10116	intact-crc:44F3A2176D02515F|rigid:9RVm0UBcqQF4k06RGKO89Bg16Q8	false	myc tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P19357	uniprotkb:P54001	intact:EBI-915426|uniprotkb:P97900|ensembl:ENSRNOP00000023256	intact:EBI-917766|uniprotkb:Q6AZ74|ensembl:ENSRNOP00000064405	psi-mi:glut4_rat(display_long)|uniprotkb:Glucose transporter type 4, insulin-responsive(gene name synonym)|uniprotkb:Slc2a4(gene name)|psi-mi:Slc2a4(display_short)|uniprotkb:Glut4(gene name synonym)	psi-mi:p4ha1_rat(display_long)|uniprotkb:Procollagen-proline,2-oxoglutarate-4-dioxygenase subunit alpha-1(gene name synonym)|uniprotkb:P4ha1(gene name)|psi-mi:P4ha1(display_short)|uniprotkb:P4ha(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Foster et al. (2006)	pubmed:16396496|mint:MINT-5218203	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-921030	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2711|refseq:NP_036883.1|refseq:XP_006246658.1|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007611"(learning or memory)|go:"GO:0007614"(short-term memory)|go:"GO:0007616"(long-term memory)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010021"(amylopectin biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031550"(positive regulation of brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044381"(glucose import in response to insulin stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046323"(glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0098694"(regulation of synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0098793"(presynapse)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002441("Glucose transporter, type 4 (GLUT4)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-189200|ensembl:ENSRNOG00000017226(gene)|ensembl:ENSRNOT00000023256(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)	ensembl:ENSRNOG00000050655(gene)|ensembl:ENSRNOT00000070897(transcript)|go:"GO:0004656"(procollagen-proline 4-dioxygenase activity)|go:"GO:0005506"(iron ion binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0016222"(procollagen-proline 4-dioxygenase complex)|go:"GO:0018401"(peptidyl-proline hydroxylation to 4-hydroxy-L-proline)|go:"GO:0030199"(collagen fibril organization)|go:"GO:0031418"(L-ascorbic acid binding)|go:"GO:0042802"(identical protein binding)|interpro:IPR005123("2OG-Fe(II) oxygenase")|interpro:IPR006620(Prolyl 4-hydroxylase, alpha subunit)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR013547(Prolyl 4-hydroxylase alpha-subunit, N-terminal)|interpro:IPR019734|reactome:R-RNO-1650814|rgd:621000|refseq:NP_742059.2|refseq:XP_006256486.1	-	-	-	caution:"The participant EBI-349571(P68370) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919386(Q7TP47) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920972(Q5XIP9) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-916419(P11980) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919578(Q8R491) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920554(Q5U3Z7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920647(Q5U2X8) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920585(Q7TP24) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-779677(P05426) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-915744(P02454) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|agonist:Insulin was shown to increase or decrease GLUT4 protein interactions in specific cases.|comment:"Insulin decreased GLUT4 interactions with the following proteins: Q9ER30 (Sarcosin), P09527 (Rab-7), O88960 (N-ethylmaleimide sensitive), P09456 (PKA I regulatory subunit), P27881 (Hexokinase type II), P07872 (Acyl-coenzyme A oxidase), Q6DGF1 (Isocitrate dehydrogenase), Q9EQX9 (Ubiquitin-conjugating), Q63446 (Polyubiquitin), P24268 (Cathepsin D), Q91XW0 (Heat shock protein 86), Q5FVH0 (unknown), P58405 (Striatin 3), Q62667 (Major vault protein), Q66H50 (unknown), Q09167 (splicing factor), Q9JHU5 (Arfaptin 1)."|comment:"Insulin increased GLUT4 interaction with the following proteins:Q9Z1P2 (R-actinin-1), P45592 (Cofilin), Q9QXQ0 (R-actinin-4), P26473 (ADP-ribosylation factor), P26437 (ADP-ribosylation factor),   Q7TNP1 (Basigin 2), Q6P6R2 (Dihydrolipoamide dehydrogenase),   P04797 (GAPDH), Q63081 (Protein disulfide isomerase), P29457 (47 kDa heat shock protein), Q9R1J8 (Leprecan), O88638 (Putative eps protein),   Q64375 (Synaptonemal complex)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:NDPK - Interactions involving proteins containing InterPro domain IPR001564, Nucleoside diphosphate kinase, core.	taxid:10116(rat-l6)|taxid:10116(Rattus norvegicus)	-	2006/02/15	2021/11/30	rogid:PbFY2lfrty8yw40Jq7ShR7xfuV410116	rogid:JxMHn3x9L6+kspJ8rU8Cni4RvMo10116	intact-crc:44F3A2176D02515F|rigid:9RVm0UBcqQF4k06RGKO89Bg16Q8	false	myc tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P19357	uniprotkb:P62907	intact:EBI-915426|uniprotkb:P97900|ensembl:ENSRNOP00000023256	intact:EBI-356868|uniprotkb:P52859|uniprotkb:P53025|ensembl:ENSRNOP00000000603	psi-mi:glut4_rat(display_long)|uniprotkb:Glucose transporter type 4, insulin-responsive(gene name synonym)|uniprotkb:Slc2a4(gene name)|psi-mi:Slc2a4(display_short)|uniprotkb:Glut4(gene name synonym)	psi-mi:rl10a_rat(display_long)|uniprotkb:Rpl10a(gene name)|psi-mi:Rpl10a(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Foster et al. (2006)	pubmed:16396496|mint:MINT-5218203	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-921030	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2711|refseq:NP_036883.1|refseq:XP_006246658.1|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007611"(learning or memory)|go:"GO:0007614"(short-term memory)|go:"GO:0007616"(long-term memory)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010021"(amylopectin biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031550"(positive regulation of brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044381"(glucose import in response to insulin stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046323"(glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0098694"(regulation of synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0098793"(presynapse)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002441("Glucose transporter, type 4 (GLUT4)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-189200|ensembl:ENSRNOG00000017226(gene)|ensembl:ENSRNOT00000023256(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)	rgd:620497|refseq:NP_112327.1|ensembl:ENSRNOG00000000505(gene)|ensembl:ENSRNOT00000000603(transcript)|go:"GO:0000470"(maturation of LSU-rRNA)|go:"GO:0002181"(cytoplasmic translation)|go:"GO:0003723"(RNA binding)|go:"GO:0003735"(structural constituent of ribosome)|go:"GO:0006412"(translation)|go:"GO:0014069"(postsynaptic density)|go:"GO:0022625"(cytosolic large ribosomal subunit)|go:"GO:0022626"(cytosolic ribosome)|go:"GO:0042788"(polysomal ribosome)|go:"GO:0045202"(synapse)|interpro:IPR002143(Ribosomal protein L1)|interpro:IPR016095(Ribosomal protein L1, 3-layer alpha/beta-sandwich)|interpro:IPR023673|interpro:IPR023674|interpro:IPR028364|reactome:R-RNO-156827|reactome:R-RNO-1799339|reactome:R-RNO-6791226|reactome:R-RNO-72689|reactome:R-RNO-72706|reactome:R-RNO-975956|reactome:R-RNO-975957|go:"GO:0045471"(response to ethanol)	-	-	-	caution:"The participant EBI-349571(P68370) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919386(Q7TP47) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920972(Q5XIP9) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-916419(P11980) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919578(Q8R491) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920554(Q5U3Z7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920647(Q5U2X8) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920585(Q7TP24) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-779677(P05426) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-915744(P02454) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|agonist:Insulin was shown to increase or decrease GLUT4 protein interactions in specific cases.|comment:"Insulin decreased GLUT4 interactions with the following proteins: Q9ER30 (Sarcosin), P09527 (Rab-7), O88960 (N-ethylmaleimide sensitive), P09456 (PKA I regulatory subunit), P27881 (Hexokinase type II), P07872 (Acyl-coenzyme A oxidase), Q6DGF1 (Isocitrate dehydrogenase), Q9EQX9 (Ubiquitin-conjugating), Q63446 (Polyubiquitin), P24268 (Cathepsin D), Q91XW0 (Heat shock protein 86), Q5FVH0 (unknown), P58405 (Striatin 3), Q62667 (Major vault protein), Q66H50 (unknown), Q09167 (splicing factor), Q9JHU5 (Arfaptin 1)."|comment:"Insulin increased GLUT4 interaction with the following proteins:Q9Z1P2 (R-actinin-1), P45592 (Cofilin), Q9QXQ0 (R-actinin-4), P26473 (ADP-ribosylation factor), P26437 (ADP-ribosylation factor),   Q7TNP1 (Basigin 2), Q6P6R2 (Dihydrolipoamide dehydrogenase),   P04797 (GAPDH), Q63081 (Protein disulfide isomerase), P29457 (47 kDa heat shock protein), Q9R1J8 (Leprecan), O88638 (Putative eps protein),   Q64375 (Synaptonemal complex)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:NDPK - Interactions involving proteins containing InterPro domain IPR001564, Nucleoside diphosphate kinase, core.	taxid:10116(rat-l6)|taxid:10116(Rattus norvegicus)	-	2006/02/15	2021/11/30	rogid:PbFY2lfrty8yw40Jq7ShR7xfuV410116	rogid:wrXKX6vzZ3ovXP3yUoL1/r+NGiw10116	intact-crc:44F3A2176D02515F|rigid:9RVm0UBcqQF4k06RGKO89Bg16Q8	false	myc tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P19357	uniprotkb:P52944	intact:EBI-915426|uniprotkb:P97900|ensembl:ENSRNOP00000023256	intact:EBI-917755|uniprotkb:Q6IN45|ensembl:ENSRNOP00000022000	psi-mi:glut4_rat(display_long)|uniprotkb:Glucose transporter type 4, insulin-responsive(gene name synonym)|uniprotkb:Slc2a4(gene name)|psi-mi:Slc2a4(display_short)|uniprotkb:Glut4(gene name synonym)	psi-mi:pdli1_rat(display_long)|uniprotkb:Elfin(gene name synonym)|uniprotkb:LIM domain protein CLP-36(gene name synonym)|uniprotkb:C-terminal LIM domain protein 1(gene name synonym)|uniprotkb:Pdlim1(gene name)|psi-mi:Pdlim1(display_short)|uniprotkb:Clim1(gene name synonym)|uniprotkb:Clp36(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Foster et al. (2006)	pubmed:16396496|mint:MINT-5218203	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-921030	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2711|refseq:NP_036883.1|refseq:XP_006246658.1|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007611"(learning or memory)|go:"GO:0007614"(short-term memory)|go:"GO:0007616"(long-term memory)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010021"(amylopectin biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031550"(positive regulation of brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044381"(glucose import in response to insulin stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046323"(glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0098694"(regulation of synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0098793"(presynapse)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002441("Glucose transporter, type 4 (GLUT4)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-189200|ensembl:ENSRNOG00000017226(gene)|ensembl:ENSRNOT00000023256(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)	interpro:IPR036034|ensembl:ENSRNOG00000016166(gene)|ensembl:ENSRNOT00000022000(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001725"(stress fiber)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0003779"(actin binding)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005912"(adherens junction)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007507"(heart development)|go:"GO:0010761"(fibroblast migration)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0030011"(maintenance of cell polarity)|go:"GO:0030018"(Z disc)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030950"(establishment or maintenance of actin cytoskeleton polarity)|go:"GO:0031941"(filamentous actin)|go:"GO:0043149"(stress fiber assembly)|go:"GO:0046872"(metal ion binding)|go:"GO:0051371"(muscle alpha-actinin binding)|go:"GO:0061061"(muscle structure development)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001781(Zinc finger, LIM-type)|interpro:IPR006643(ZASP)|interpro:IPR028537|interpro:IPR031847|rgd:68324|refseq:NP_059061.1	-	-	-	caution:"The participant EBI-349571(P68370) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919386(Q7TP47) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920972(Q5XIP9) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-916419(P11980) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919578(Q8R491) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920554(Q5U3Z7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920647(Q5U2X8) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920585(Q7TP24) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-779677(P05426) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-915744(P02454) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|agonist:Insulin was shown to increase or decrease GLUT4 protein interactions in specific cases.|comment:"Insulin decreased GLUT4 interactions with the following proteins: Q9ER30 (Sarcosin), P09527 (Rab-7), O88960 (N-ethylmaleimide sensitive), P09456 (PKA I regulatory subunit), P27881 (Hexokinase type II), P07872 (Acyl-coenzyme A oxidase), Q6DGF1 (Isocitrate dehydrogenase), Q9EQX9 (Ubiquitin-conjugating), Q63446 (Polyubiquitin), P24268 (Cathepsin D), Q91XW0 (Heat shock protein 86), Q5FVH0 (unknown), P58405 (Striatin 3), Q62667 (Major vault protein), Q66H50 (unknown), Q09167 (splicing factor), Q9JHU5 (Arfaptin 1)."|comment:"Insulin increased GLUT4 interaction with the following proteins:Q9Z1P2 (R-actinin-1), P45592 (Cofilin), Q9QXQ0 (R-actinin-4), P26473 (ADP-ribosylation factor), P26437 (ADP-ribosylation factor),   Q7TNP1 (Basigin 2), Q6P6R2 (Dihydrolipoamide dehydrogenase),   P04797 (GAPDH), Q63081 (Protein disulfide isomerase), P29457 (47 kDa heat shock protein), Q9R1J8 (Leprecan), O88638 (Putative eps protein),   Q64375 (Synaptonemal complex)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:NDPK - Interactions involving proteins containing InterPro domain IPR001564, Nucleoside diphosphate kinase, core.	taxid:10116(rat-l6)|taxid:10116(Rattus norvegicus)	-	2006/02/15	2021/11/30	rogid:PbFY2lfrty8yw40Jq7ShR7xfuV410116	rogid:5n1R7xSRSMM2XfwhMCv9aKWtINg10116	intact-crc:44F3A2176D02515F|rigid:9RVm0UBcqQF4k06RGKO89Bg16Q8	false	myc tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P19357	uniprotkb:P52555	intact:EBI-915426|uniprotkb:P97900|ensembl:ENSRNOP00000023256	intact:EBI-917740|uniprotkb:P80749|uniprotkb:Q5BKC2|ensembl:ENSRNOP00000001822|ensembl:ENSRNOP00000072413	psi-mi:glut4_rat(display_long)|uniprotkb:Glucose transporter type 4, insulin-responsive(gene name synonym)|uniprotkb:Slc2a4(gene name)|psi-mi:Slc2a4(display_short)|uniprotkb:Glut4(gene name synonym)	psi-mi:erp29_rat(display_long)|uniprotkb:Endoplasmic reticulum resident protein 31(gene name synonym)|uniprotkb:Erp29(gene name)|psi-mi:Erp29(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Foster et al. (2006)	pubmed:16396496|mint:MINT-5218203	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-921030	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2711|refseq:NP_036883.1|refseq:XP_006246658.1|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007611"(learning or memory)|go:"GO:0007614"(short-term memory)|go:"GO:0007616"(long-term memory)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010021"(amylopectin biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031550"(positive regulation of brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044381"(glucose import in response to insulin stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046323"(glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0098694"(regulation of synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0098793"(presynapse)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002441("Glucose transporter, type 4 (GLUT4)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-189200|ensembl:ENSRNOG00000017226(gene)|ensembl:ENSRNOT00000023256(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)	ensembl:ENSRNOG00000001348(gene)|ensembl:ENSRNOT00000001822(transcript)|ensembl:ENSRNOT00000081016(transcript)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005790"(smooth endoplasmic reticulum)|go:"GO:0006457"(protein folding)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0009306"(protein secretion)|go:"GO:0009986"(cell surface)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0030133"(transport vesicle)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0042470"(melanosome)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0050709"(negative regulation of protein secretion)|go:"GO:0051087"(chaperone binding)|go:"GO:1902235"(regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway)|interpro:IPR011679(Endoplasmic reticulum, protein ERp29, C-terminal)|interpro:IPR012883(ERp29, N-terminal)|interpro:IPR016855(Endoplasmic reticulum, protein ERp29)|interpro:IPR036249|interpro:IPR036356|rcsb pdb:1G7D|rcsb pdb:1G7E|rcsb pdb:2M66|rcsb pdb:6O6I|rgd:619781|refseq:NP_446413.1	-	-	-	caution:"The participant EBI-349571(P68370) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919386(Q7TP47) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920972(Q5XIP9) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-916419(P11980) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919578(Q8R491) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920554(Q5U3Z7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920647(Q5U2X8) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920585(Q7TP24) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-779677(P05426) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-915744(P02454) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|agonist:Insulin was shown to increase or decrease GLUT4 protein interactions in specific cases.|comment:"Insulin decreased GLUT4 interactions with the following proteins: Q9ER30 (Sarcosin), P09527 (Rab-7), O88960 (N-ethylmaleimide sensitive), P09456 (PKA I regulatory subunit), P27881 (Hexokinase type II), P07872 (Acyl-coenzyme A oxidase), Q6DGF1 (Isocitrate dehydrogenase), Q9EQX9 (Ubiquitin-conjugating), Q63446 (Polyubiquitin), P24268 (Cathepsin D), Q91XW0 (Heat shock protein 86), Q5FVH0 (unknown), P58405 (Striatin 3), Q62667 (Major vault protein), Q66H50 (unknown), Q09167 (splicing factor), Q9JHU5 (Arfaptin 1)."|comment:"Insulin increased GLUT4 interaction with the following proteins:Q9Z1P2 (R-actinin-1), P45592 (Cofilin), Q9QXQ0 (R-actinin-4), P26473 (ADP-ribosylation factor), P26437 (ADP-ribosylation factor),   Q7TNP1 (Basigin 2), Q6P6R2 (Dihydrolipoamide dehydrogenase),   P04797 (GAPDH), Q63081 (Protein disulfide isomerase), P29457 (47 kDa heat shock protein), Q9R1J8 (Leprecan), O88638 (Putative eps protein),   Q64375 (Synaptonemal complex)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:NDPK - Interactions involving proteins containing InterPro domain IPR001564, Nucleoside diphosphate kinase, core.	taxid:10116(rat-l6)|taxid:10116(Rattus norvegicus)	-	2006/02/15	2021/11/30	rogid:PbFY2lfrty8yw40Jq7ShR7xfuV410116	rogid:gu5pdstglhP/eAFcYEBVXYLMcxo10116	intact-crc:44F3A2176D02515F|rigid:9RVm0UBcqQF4k06RGKO89Bg16Q8	false	myc tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P19357	uniprotkb:P52296	intact:EBI-915426|uniprotkb:P97900|ensembl:ENSRNOP00000023256	intact:EBI-917731|intact:EBI-11702595	psi-mi:glut4_rat(display_long)|uniprotkb:Glucose transporter type 4, insulin-responsive(gene name synonym)|uniprotkb:Slc2a4(gene name)|psi-mi:Slc2a4(display_short)|uniprotkb:Glut4(gene name synonym)	psi-mi:imb1_rat(display_long)|uniprotkb:Karyopherin subunit beta-1(gene name synonym)|uniprotkb:Nuclear factor p97(gene name synonym)|uniprotkb:Kpnb1(gene name)|psi-mi:Kpnb1(display_short)|uniprotkb:Pore targeting complex 97 kDa subunit(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Foster et al. (2006)	pubmed:16396496|mint:MINT-5218203	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-921030	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2711|refseq:NP_036883.1|refseq:XP_006246658.1|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007611"(learning or memory)|go:"GO:0007614"(short-term memory)|go:"GO:0007616"(long-term memory)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010021"(amylopectin biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031550"(positive regulation of brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044381"(glucose import in response to insulin stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046323"(glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0098694"(regulation of synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0098793"(presynapse)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002441("Glucose transporter, type 4 (GLUT4)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-189200|ensembl:ENSRNOG00000017226(gene)|ensembl:ENSRNOT00000023256(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)	go:"GO:0005634"(nucleus)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005643"(nuclear pore)|go:"GO:0005737"(cytoplasm)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0006610"(ribosomal protein import into nucleus)|go:"GO:0007079"(mitotic chromosome movement towards spindle pole)|go:"GO:0007080"(mitotic metaphase plate congression)|go:"GO:0008139"(nuclear localization sequence binding)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0019894"(kinesin binding)|go:"GO:0019899"(enzyme binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030953"(astral microtubule organization)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031291"(Ran protein signal transduction)|go:"GO:0032991"(protein-containing complex)|go:"GO:0040001"(establishment of mitotic spindle localization)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045184"(establishment of protein localization)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0061608"(nuclear import signal receptor activity)|go:"GO:0061676"(importin-alpha family protein binding)|go:"GO:0071782"(endoplasmic reticulum tubular network)|go:"GO:0090307"(mitotic spindle assembly)|interpro:IPR000225(Armadillo)|interpro:IPR001494(Importin-beta, N-terminal)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR021133|interpro:IPR040122|reactome:R-RNO-140342|reactome:R-RNO-1655829|reactome:R-RNO-6798695|reactome:R-RNO-909733|rgd:2909|refseq:NP_058759.1|mint:P52296|dip:DIP-37024N	-	-	-	caution:"The participant EBI-349571(P68370) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919386(Q7TP47) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920972(Q5XIP9) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-916419(P11980) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919578(Q8R491) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920554(Q5U3Z7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920647(Q5U2X8) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920585(Q7TP24) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-779677(P05426) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-915744(P02454) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|agonist:Insulin was shown to increase or decrease GLUT4 protein interactions in specific cases.|comment:"Insulin decreased GLUT4 interactions with the following proteins: Q9ER30 (Sarcosin), P09527 (Rab-7), O88960 (N-ethylmaleimide sensitive), P09456 (PKA I regulatory subunit), P27881 (Hexokinase type II), P07872 (Acyl-coenzyme A oxidase), Q6DGF1 (Isocitrate dehydrogenase), Q9EQX9 (Ubiquitin-conjugating), Q63446 (Polyubiquitin), P24268 (Cathepsin D), Q91XW0 (Heat shock protein 86), Q5FVH0 (unknown), P58405 (Striatin 3), Q62667 (Major vault protein), Q66H50 (unknown), Q09167 (splicing factor), Q9JHU5 (Arfaptin 1)."|comment:"Insulin increased GLUT4 interaction with the following proteins:Q9Z1P2 (R-actinin-1), P45592 (Cofilin), Q9QXQ0 (R-actinin-4), P26473 (ADP-ribosylation factor), P26437 (ADP-ribosylation factor),   Q7TNP1 (Basigin 2), Q6P6R2 (Dihydrolipoamide dehydrogenase),   P04797 (GAPDH), Q63081 (Protein disulfide isomerase), P29457 (47 kDa heat shock protein), Q9R1J8 (Leprecan), O88638 (Putative eps protein),   Q64375 (Synaptonemal complex)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:NDPK - Interactions involving proteins containing InterPro domain IPR001564, Nucleoside diphosphate kinase, core.	taxid:10116(rat-l6)|taxid:10116(Rattus norvegicus)	-	2006/02/15	2021/11/30	rogid:PbFY2lfrty8yw40Jq7ShR7xfuV410116	rogid:i8sGTTT4N+V1jz6fLjdodopKXfQ10116	intact-crc:44F3A2176D02515F|rigid:9RVm0UBcqQF4k06RGKO89Bg16Q8	false	myc tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P19357	uniprotkb:P51868	intact:EBI-915426|uniprotkb:P97900|ensembl:ENSRNOP00000023256	intact:EBI-917722|uniprotkb:O09177|uniprotkb:Q6IMX1	psi-mi:glut4_rat(display_long)|uniprotkb:Glucose transporter type 4, insulin-responsive(gene name synonym)|uniprotkb:Slc2a4(gene name)|psi-mi:Slc2a4(display_short)|uniprotkb:Glut4(gene name synonym)	psi-mi:casq2_rat(display_long)|uniprotkb:Calsequestrin, cardiac muscle isoform(gene name synonym)|uniprotkb:Casq2(gene name)|psi-mi:Casq2(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Foster et al. (2006)	pubmed:16396496|mint:MINT-5218203	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-921030	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2711|refseq:NP_036883.1|refseq:XP_006246658.1|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007611"(learning or memory)|go:"GO:0007614"(short-term memory)|go:"GO:0007616"(long-term memory)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010021"(amylopectin biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031550"(positive regulation of brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044381"(glucose import in response to insulin stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046323"(glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0098694"(regulation of synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0098793"(presynapse)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002441("Glucose transporter, type 4 (GLUT4)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-189200|ensembl:ENSRNOG00000017226(gene)|ensembl:ENSRNOT00000023256(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)	rgd:2276|refseq:NP_058827.3|interpro:IPR001393(Calsequestrin)|interpro:IPR018233|go:"GO:0002027"(regulation of heart rate)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0010649"(regulation of cell communication by electrical coupling)|go:"GO:0010880"(regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum)|go:"GO:0010881"(regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030018"(Z disc)|go:"GO:0030314"(junctional membrane complex)|go:"GO:0033018"(sarcoplasmic reticulum lumen)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043267"(negative regulation of potassium ion transport)|go:"GO:0045214"(sarcomere organization)|go:"GO:0048306"(calcium-dependent protein binding)|go:"GO:0051208"(sequestering of calcium ion)|go:"GO:0051258"(protein polymerization)|go:"GO:0051279"(regulation of release of sequestered calcium ion into cytosol)|go:"GO:0060048"(cardiac muscle contraction)|go:"GO:0060306"(regulation of membrane repolarization)|go:"GO:0060315"(negative regulation of ryanodine-sensitive calcium-release channel activity)|go:"GO:0071313"(cellular response to caffeine)|go:"GO:0086004"(regulation of cardiac muscle cell contraction)|go:"GO:1901017"(negative regulation of potassium ion transmembrane transporter activity)|reactome:R-RNO-2672351|reactome:R-RNO-5578775|mint:P51868|interpro:IPR036249|interpro:IPR041858|interpro:IPR041859|interpro:IPR041860	-	-	-	caution:"The participant EBI-349571(P68370) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919386(Q7TP47) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920972(Q5XIP9) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-916419(P11980) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919578(Q8R491) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920554(Q5U3Z7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920647(Q5U2X8) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920585(Q7TP24) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-779677(P05426) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-915744(P02454) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|agonist:Insulin was shown to increase or decrease GLUT4 protein interactions in specific cases.|comment:"Insulin decreased GLUT4 interactions with the following proteins: Q9ER30 (Sarcosin), P09527 (Rab-7), O88960 (N-ethylmaleimide sensitive), P09456 (PKA I regulatory subunit), P27881 (Hexokinase type II), P07872 (Acyl-coenzyme A oxidase), Q6DGF1 (Isocitrate dehydrogenase), Q9EQX9 (Ubiquitin-conjugating), Q63446 (Polyubiquitin), P24268 (Cathepsin D), Q91XW0 (Heat shock protein 86), Q5FVH0 (unknown), P58405 (Striatin 3), Q62667 (Major vault protein), Q66H50 (unknown), Q09167 (splicing factor), Q9JHU5 (Arfaptin 1)."|comment:"Insulin increased GLUT4 interaction with the following proteins:Q9Z1P2 (R-actinin-1), P45592 (Cofilin), Q9QXQ0 (R-actinin-4), P26473 (ADP-ribosylation factor), P26437 (ADP-ribosylation factor),   Q7TNP1 (Basigin 2), Q6P6R2 (Dihydrolipoamide dehydrogenase),   P04797 (GAPDH), Q63081 (Protein disulfide isomerase), P29457 (47 kDa heat shock protein), Q9R1J8 (Leprecan), O88638 (Putative eps protein),   Q64375 (Synaptonemal complex)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:NDPK - Interactions involving proteins containing InterPro domain IPR001564, Nucleoside diphosphate kinase, core.	taxid:10116(rat-l6)|taxid:10116(Rattus norvegicus)	-	2006/02/15	2021/11/30	rogid:PbFY2lfrty8yw40Jq7ShR7xfuV410116	rogid:7iJwnAEOBYCPFh2MZkEWjAPQhNE10116	intact-crc:44F3A2176D02515F|rigid:9RVm0UBcqQF4k06RGKO89Bg16Q8	false	myc tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P19357	uniprotkb:P51583	intact:EBI-915426|uniprotkb:P97900|ensembl:ENSRNOP00000023256	intact:EBI-917714|ensembl:ENSRNOP00000061495	psi-mi:glut4_rat(display_long)|uniprotkb:Glucose transporter type 4, insulin-responsive(gene name synonym)|uniprotkb:Slc2a4(gene name)|psi-mi:Slc2a4(display_short)|uniprotkb:Glut4(gene name synonym)	psi-mi:pur6_rat(display_long)|uniprotkb:Paics(gene name)|psi-mi:Paics(display_short)|uniprotkb:Ade2(gene name synonym)|uniprotkb:Airc(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Foster et al. (2006)	pubmed:16396496|mint:MINT-5218203	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-921030	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2711|refseq:NP_036883.1|refseq:XP_006246658.1|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007611"(learning or memory)|go:"GO:0007614"(short-term memory)|go:"GO:0007616"(long-term memory)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010021"(amylopectin biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031550"(positive regulation of brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044381"(glucose import in response to insulin stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046323"(glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0098694"(regulation of synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0098793"(presynapse)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002441("Glucose transporter, type 4 (GLUT4)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-189200|ensembl:ENSRNOG00000017226(gene)|ensembl:ENSRNOT00000023256(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)	rgd:620066|refseq:NP_543186.1|interpro:IPR028923|interpro:IPR033626|reactome:R-RNO-73817|ensembl:ENSRNOG00000002101(gene)|ensembl:ENSRNOT00000063942(transcript)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0004638"(phosphoribosylaminoimidazole carboxylase activity)|go:"GO:0004639"(phosphoribosylaminoimidazolesuccinocarboxamide synthase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006189"('de novo' IMP biosynthetic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0043727"(5-amino-4-imidazole carboxylate lyase activity)|interpro:IPR000031("1-(5-Phosphoribosyl)-5-amino-4-imidazole-carboxylate (AIR) carboxylase")|interpro:IPR018236|refseq:XP_006250914.1|refseq:XP_006250915.1|refseq:XP_006250916.1	-	-	-	caution:"The participant EBI-349571(P68370) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919386(Q7TP47) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920972(Q5XIP9) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-916419(P11980) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919578(Q8R491) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920554(Q5U3Z7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920647(Q5U2X8) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920585(Q7TP24) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-779677(P05426) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-915744(P02454) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|agonist:Insulin was shown to increase or decrease GLUT4 protein interactions in specific cases.|comment:"Insulin decreased GLUT4 interactions with the following proteins: Q9ER30 (Sarcosin), P09527 (Rab-7), O88960 (N-ethylmaleimide sensitive), P09456 (PKA I regulatory subunit), P27881 (Hexokinase type II), P07872 (Acyl-coenzyme A oxidase), Q6DGF1 (Isocitrate dehydrogenase), Q9EQX9 (Ubiquitin-conjugating), Q63446 (Polyubiquitin), P24268 (Cathepsin D), Q91XW0 (Heat shock protein 86), Q5FVH0 (unknown), P58405 (Striatin 3), Q62667 (Major vault protein), Q66H50 (unknown), Q09167 (splicing factor), Q9JHU5 (Arfaptin 1)."|comment:"Insulin increased GLUT4 interaction with the following proteins:Q9Z1P2 (R-actinin-1), P45592 (Cofilin), Q9QXQ0 (R-actinin-4), P26473 (ADP-ribosylation factor), P26437 (ADP-ribosylation factor),   Q7TNP1 (Basigin 2), Q6P6R2 (Dihydrolipoamide dehydrogenase),   P04797 (GAPDH), Q63081 (Protein disulfide isomerase), P29457 (47 kDa heat shock protein), Q9R1J8 (Leprecan), O88638 (Putative eps protein),   Q64375 (Synaptonemal complex)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:NDPK - Interactions involving proteins containing InterPro domain IPR001564, Nucleoside diphosphate kinase, core.	taxid:10116(rat-l6)|taxid:10116(Rattus norvegicus)	-	2006/02/15	2021/11/30	rogid:PbFY2lfrty8yw40Jq7ShR7xfuV410116	rogid:oXbwn0+PpGglwIvb7zwI27LJQyc10116	intact-crc:44F3A2176D02515F|rigid:9RVm0UBcqQF4k06RGKO89Bg16Q8	false	myc tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P19357	uniprotkb:P50878	intact:EBI-915426|uniprotkb:P97900|ensembl:ENSRNOP00000023256	intact:EBI-917707	psi-mi:glut4_rat(display_long)|uniprotkb:Glucose transporter type 4, insulin-responsive(gene name synonym)|uniprotkb:Slc2a4(gene name)|psi-mi:Slc2a4(display_short)|uniprotkb:Glut4(gene name synonym)	psi-mi:rl4_rat(display_long)|uniprotkb:60S ribosomal protein L1(gene name synonym)|uniprotkb:Rpl4(gene name)|psi-mi:Rpl4(display_short)|uniprotkb:Rpl1(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Foster et al. (2006)	pubmed:16396496|mint:MINT-5218203	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-921030	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2711|refseq:NP_036883.1|refseq:XP_006246658.1|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007611"(learning or memory)|go:"GO:0007614"(short-term memory)|go:"GO:0007616"(long-term memory)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010021"(amylopectin biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031550"(positive regulation of brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044381"(glucose import in response to insulin stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046323"(glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0098694"(regulation of synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0098793"(presynapse)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002441("Glucose transporter, type 4 (GLUT4)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-189200|ensembl:ENSRNOG00000017226(gene)|ensembl:ENSRNOT00000023256(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)	interpro:IPR002136(Ribosomal protein L4/L1e)|interpro:IPR013000(Ribosomal protein L4/L1e, eukaryotic/archaeal, conserved site)|interpro:IPR023574|rgd:619824|refseq:NP_071955.1|mint:P50878|go:"GO:0003360"(brainstem development)|go:"GO:0003723"(RNA binding)|go:"GO:0003735"(structural constituent of ribosome)|go:"GO:0005634"(nucleus)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0006412"(translation)|go:"GO:0007420"(brain development)|go:"GO:0008097"(5S rRNA binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015934"(large ribosomal subunit)|go:"GO:0022625"(cytosolic large ribosomal subunit)|go:"GO:0022626"(cytosolic ribosome)|go:"GO:0030154"(cell differentiation)|go:"GO:0031672"(A band)|go:"GO:0045773"(positive regulation of axon extension)|go:"GO:0050772"(positive regulation of axonogenesis)|go:"GO:0071417"(cellular response to organonitrogen compound)|go:"GO:1990904"(ribonucleoprotein complex)|reactome:R-RNO-156827|reactome:R-RNO-1799339|reactome:R-RNO-6791226|reactome:R-RNO-72689|reactome:R-RNO-72706|reactome:R-RNO-975956|reactome:R-RNO-975957|interpro:IPR025755	-	-	-	caution:"The participant EBI-349571(P68370) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919386(Q7TP47) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920972(Q5XIP9) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-916419(P11980) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919578(Q8R491) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920554(Q5U3Z7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920647(Q5U2X8) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920585(Q7TP24) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-779677(P05426) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-915744(P02454) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|agonist:Insulin was shown to increase or decrease GLUT4 protein interactions in specific cases.|comment:"Insulin decreased GLUT4 interactions with the following proteins: Q9ER30 (Sarcosin), P09527 (Rab-7), O88960 (N-ethylmaleimide sensitive), P09456 (PKA I regulatory subunit), P27881 (Hexokinase type II), P07872 (Acyl-coenzyme A oxidase), Q6DGF1 (Isocitrate dehydrogenase), Q9EQX9 (Ubiquitin-conjugating), Q63446 (Polyubiquitin), P24268 (Cathepsin D), Q91XW0 (Heat shock protein 86), Q5FVH0 (unknown), P58405 (Striatin 3), Q62667 (Major vault protein), Q66H50 (unknown), Q09167 (splicing factor), Q9JHU5 (Arfaptin 1)."|comment:"Insulin increased GLUT4 interaction with the following proteins:Q9Z1P2 (R-actinin-1), P45592 (Cofilin), Q9QXQ0 (R-actinin-4), P26473 (ADP-ribosylation factor), P26437 (ADP-ribosylation factor),   Q7TNP1 (Basigin 2), Q6P6R2 (Dihydrolipoamide dehydrogenase),   P04797 (GAPDH), Q63081 (Protein disulfide isomerase), P29457 (47 kDa heat shock protein), Q9R1J8 (Leprecan), O88638 (Putative eps protein),   Q64375 (Synaptonemal complex)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:NDPK - Interactions involving proteins containing InterPro domain IPR001564, Nucleoside diphosphate kinase, core.	taxid:10116(rat-l6)|taxid:10116(Rattus norvegicus)	-	2006/02/15	2021/11/30	rogid:PbFY2lfrty8yw40Jq7ShR7xfuV410116	rogid:MBNLNgdqGuXGfOSGP+q3/5Cs9dw10116	intact-crc:44F3A2176D02515F|rigid:9RVm0UBcqQF4k06RGKO89Bg16Q8	false	myc tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P19357	uniprotkb:P62815	intact:EBI-915426|uniprotkb:P97900|ensembl:ENSRNOP00000023256	intact:EBI-772667|uniprotkb:O09045|uniprotkb:P50517|ensembl:ENSRNOP00000015931	psi-mi:glut4_rat(display_long)|uniprotkb:Glucose transporter type 4, insulin-responsive(gene name synonym)|uniprotkb:Slc2a4(gene name)|psi-mi:Slc2a4(display_short)|uniprotkb:Glut4(gene name synonym)	psi-mi:vatb2_rat(display_long)|uniprotkb:Vacuolar proton pump subunit B 2(gene name synonym)|uniprotkb:Endomembrane proton pump 58 kDa subunit(gene name synonym)|uniprotkb:Atp6v1b2(gene name)|psi-mi:Atp6v1b2(display_short)|uniprotkb:Atp6b2(gene name synonym)|uniprotkb:Vat2(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Foster et al. (2006)	pubmed:16396496|mint:MINT-5218203	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-921030	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2711|refseq:NP_036883.1|refseq:XP_006246658.1|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007611"(learning or memory)|go:"GO:0007614"(short-term memory)|go:"GO:0007616"(long-term memory)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010021"(amylopectin biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031550"(positive regulation of brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044381"(glucose import in response to insulin stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046323"(glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0098694"(regulation of synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0098793"(presynapse)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002441("Glucose transporter, type 4 (GLUT4)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-189200|ensembl:ENSRNOG00000017226(gene)|ensembl:ENSRNOT00000023256(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)	rgd:620284|refseq:NP_476561.1|ensembl:ENSRNOG00000011891(gene)|ensembl:ENSRNOT00000015931(transcript)|go:"GO:0000221"(vacuolar proton-transporting V-type ATPase, V1 domain)|go:"GO:0001726"(ruffle)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007035"(vacuolar acidification)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016787"(hydrolase activity)|go:"GO:0030641"(regulation of cellular pH)|go:"GO:0042470"(melanosome)|go:"GO:0046034"(ATP metabolic process)|go:"GO:1902600"(proton transmembrane transport)|interpro:IPR000194(ATPase, F1/V1/A1 complex, alpha/beta subunit, nucleotide-binding)|interpro:IPR004100(ATPase, F1/V1/A1 complex, alpha/beta subunit, N-terminal)|interpro:IPR005723(ATPase, V1 complex, subunit B)|interpro:IPR020003|interpro:IPR022879|interpro:IPR027417|mint:P62815|rcsb pdb:6VQ6|rcsb pdb:6VQ7|rcsb pdb:6VQ8|rcsb pdb:6VQ9|rcsb pdb:6VQA|rcsb pdb:6VQB|reactome:R-RNO-1222556|reactome:R-RNO-77387|reactome:R-RNO-917977|reactome:R-RNO-9639288|reactome:R-RNO-983712	-	-	-	caution:"The participant EBI-349571(P68370) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919386(Q7TP47) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920972(Q5XIP9) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-916419(P11980) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919578(Q8R491) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920554(Q5U3Z7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920647(Q5U2X8) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920585(Q7TP24) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-779677(P05426) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-915744(P02454) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|agonist:Insulin was shown to increase or decrease GLUT4 protein interactions in specific cases.|comment:"Insulin decreased GLUT4 interactions with the following proteins: Q9ER30 (Sarcosin), P09527 (Rab-7), O88960 (N-ethylmaleimide sensitive), P09456 (PKA I regulatory subunit), P27881 (Hexokinase type II), P07872 (Acyl-coenzyme A oxidase), Q6DGF1 (Isocitrate dehydrogenase), Q9EQX9 (Ubiquitin-conjugating), Q63446 (Polyubiquitin), P24268 (Cathepsin D), Q91XW0 (Heat shock protein 86), Q5FVH0 (unknown), P58405 (Striatin 3), Q62667 (Major vault protein), Q66H50 (unknown), Q09167 (splicing factor), Q9JHU5 (Arfaptin 1)."|comment:"Insulin increased GLUT4 interaction with the following proteins:Q9Z1P2 (R-actinin-1), P45592 (Cofilin), Q9QXQ0 (R-actinin-4), P26473 (ADP-ribosylation factor), P26437 (ADP-ribosylation factor),   Q7TNP1 (Basigin 2), Q6P6R2 (Dihydrolipoamide dehydrogenase),   P04797 (GAPDH), Q63081 (Protein disulfide isomerase), P29457 (47 kDa heat shock protein), Q9R1J8 (Leprecan), O88638 (Putative eps protein),   Q64375 (Synaptonemal complex)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:NDPK - Interactions involving proteins containing InterPro domain IPR001564, Nucleoside diphosphate kinase, core.	taxid:10116(rat-l6)|taxid:10116(Rattus norvegicus)	-	2006/02/15	2021/11/30	rogid:PbFY2lfrty8yw40Jq7ShR7xfuV410116	rogid:cmFm/xe3iOTqmy849cfoi4XeG+A10116	intact-crc:44F3A2176D02515F|rigid:9RVm0UBcqQF4k06RGKO89Bg16Q8	false	myc tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P19357	uniprotkb:P50503	intact:EBI-915426|uniprotkb:P97900|ensembl:ENSRNOP00000023256	intact:EBI-917694|ensembl:ENSRNOP00000025925	psi-mi:glut4_rat(display_long)|uniprotkb:Glucose transporter type 4, insulin-responsive(gene name synonym)|uniprotkb:Slc2a4(gene name)|psi-mi:Slc2a4(display_short)|uniprotkb:Glut4(gene name synonym)	psi-mi:f10a1_rat(display_long)|uniprotkb:Protein ST13 homolog(gene name synonym)|uniprotkb:Protein FAM10A1(gene name synonym)|uniprotkb:St13(gene name)|psi-mi:St13(display_short)|uniprotkb:Fam10a1(gene name synonym)|uniprotkb:Hip(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Foster et al. (2006)	pubmed:16396496|mint:MINT-5218203	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-921030	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2711|refseq:NP_036883.1|refseq:XP_006246658.1|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007611"(learning or memory)|go:"GO:0007614"(short-term memory)|go:"GO:0007616"(long-term memory)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010021"(amylopectin biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031550"(positive regulation of brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044381"(glucose import in response to insulin stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046323"(glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0098694"(regulation of synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0098793"(presynapse)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002441("Glucose transporter, type 4 (GLUT4)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-189200|ensembl:ENSRNOG00000017226(gene)|ensembl:ENSRNOT00000023256(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)	rgd:621312|refseq:NP_112384.1|ensembl:ENSRNOG00000019070(gene)|ensembl:ENSRNOT00000025925(transcript)|go:"GO:0005829"(cytosol)|go:"GO:0009617"(response to bacterium)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0032564"(dATP binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042802"(identical protein binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051085"(chaperone cofactor-dependent protein refolding)|go:"GO:0051087"(chaperone binding)|go:"GO:0061084"(negative regulation of protein refolding)|go:"GO:0065003"(protein-containing complex assembly)|interpro:IPR006636(Heat shock chaperonin-binding)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|interpro:IPR034649|interpro:IPR041243|rcsb pdb:4J8C|rcsb pdb:4J8D|rcsb pdb:4J8E|rcsb pdb:4J8F|reactome:R-RNO-3371453|dip:DIP-37019N	-	-	-	caution:"The participant EBI-349571(P68370) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919386(Q7TP47) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920972(Q5XIP9) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-916419(P11980) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919578(Q8R491) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920554(Q5U3Z7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920647(Q5U2X8) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920585(Q7TP24) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-779677(P05426) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-915744(P02454) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|agonist:Insulin was shown to increase or decrease GLUT4 protein interactions in specific cases.|comment:"Insulin decreased GLUT4 interactions with the following proteins: Q9ER30 (Sarcosin), P09527 (Rab-7), O88960 (N-ethylmaleimide sensitive), P09456 (PKA I regulatory subunit), P27881 (Hexokinase type II), P07872 (Acyl-coenzyme A oxidase), Q6DGF1 (Isocitrate dehydrogenase), Q9EQX9 (Ubiquitin-conjugating), Q63446 (Polyubiquitin), P24268 (Cathepsin D), Q91XW0 (Heat shock protein 86), Q5FVH0 (unknown), P58405 (Striatin 3), Q62667 (Major vault protein), Q66H50 (unknown), Q09167 (splicing factor), Q9JHU5 (Arfaptin 1)."|comment:"Insulin increased GLUT4 interaction with the following proteins:Q9Z1P2 (R-actinin-1), P45592 (Cofilin), Q9QXQ0 (R-actinin-4), P26473 (ADP-ribosylation factor), P26437 (ADP-ribosylation factor),   Q7TNP1 (Basigin 2), Q6P6R2 (Dihydrolipoamide dehydrogenase),   P04797 (GAPDH), Q63081 (Protein disulfide isomerase), P29457 (47 kDa heat shock protein), Q9R1J8 (Leprecan), O88638 (Putative eps protein),   Q64375 (Synaptonemal complex)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:NDPK - Interactions involving proteins containing InterPro domain IPR001564, Nucleoside diphosphate kinase, core.	taxid:10116(rat-l6)|taxid:10116(Rattus norvegicus)	-	2006/02/15	2021/11/30	rogid:PbFY2lfrty8yw40Jq7ShR7xfuV410116	rogid:WSD2xNhhB9fSCire077pTXeV/gk10116	intact-crc:44F3A2176D02515F|rigid:9RVm0UBcqQF4k06RGKO89Bg16Q8	false	myc tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P19357	uniprotkb:P50430	intact:EBI-915426|uniprotkb:P97900|ensembl:ENSRNOP00000023256	intact:EBI-917688|uniprotkb:Q32KK1|ensembl:ENSRNOP00000014860	psi-mi:glut4_rat(display_long)|uniprotkb:Glucose transporter type 4, insulin-responsive(gene name synonym)|uniprotkb:Slc2a4(gene name)|psi-mi:Slc2a4(display_short)|uniprotkb:Glut4(gene name synonym)	psi-mi:arsb_rat(display_long)|uniprotkb:N-acetylgalactosamine-4-sulfatase(gene name synonym)|uniprotkb:Arsb(gene name)|psi-mi:Arsb(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Foster et al. (2006)	pubmed:16396496|mint:MINT-5218203	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-921030	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2711|refseq:NP_036883.1|refseq:XP_006246658.1|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007611"(learning or memory)|go:"GO:0007614"(short-term memory)|go:"GO:0007616"(long-term memory)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010021"(amylopectin biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031550"(positive regulation of brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044381"(glucose import in response to insulin stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046323"(glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0098694"(regulation of synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0098793"(presynapse)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002441("Glucose transporter, type 4 (GLUT4)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-189200|ensembl:ENSRNOG00000017226(gene)|ensembl:ENSRNOT00000023256(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)	rgd:2158|refseq:NP_254278.1|ensembl:ENSRNOG00000011150(gene)|ensembl:ENSRNOT00000014860(transcript)|go:"GO:0003943"(N-acetylgalactosamine-4-sulfatase activity)|go:"GO:0004065"(arylsulfatase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0005764"(lysosome)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0006914"(autophagy)|go:"GO:0007417"(central nervous system development)|go:"GO:0007584"(response to nutrient)|go:"GO:0008484"(sulfuric ester hydrolase activity)|go:"GO:0009268"(response to pH)|go:"GO:0009986"(cell surface)|go:"GO:0010632"(regulation of epithelial cell migration)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0043627"(response to estrogen)|go:"GO:0046872"(metal ion binding)|go:"GO:0051597"(response to methylmercury)|go:"GO:0061580"(colon epithelial cell migration)|go:"GO:0097065"(anterior head development)|interpro:IPR000917(Sulphatase)|interpro:IPR017850(Alkaline-phosphatase-like, core domain)|interpro:IPR024607|reactome:R-RNO-1660662|reactome:R-RNO-1663150|reactome:R-RNO-2024101|reactome:R-RNO-6798695	-	-	-	caution:"The participant EBI-349571(P68370) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919386(Q7TP47) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920972(Q5XIP9) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-916419(P11980) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919578(Q8R491) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920554(Q5U3Z7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920647(Q5U2X8) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920585(Q7TP24) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-779677(P05426) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-915744(P02454) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|agonist:Insulin was shown to increase or decrease GLUT4 protein interactions in specific cases.|comment:"Insulin decreased GLUT4 interactions with the following proteins: Q9ER30 (Sarcosin), P09527 (Rab-7), O88960 (N-ethylmaleimide sensitive), P09456 (PKA I regulatory subunit), P27881 (Hexokinase type II), P07872 (Acyl-coenzyme A oxidase), Q6DGF1 (Isocitrate dehydrogenase), Q9EQX9 (Ubiquitin-conjugating), Q63446 (Polyubiquitin), P24268 (Cathepsin D), Q91XW0 (Heat shock protein 86), Q5FVH0 (unknown), P58405 (Striatin 3), Q62667 (Major vault protein), Q66H50 (unknown), Q09167 (splicing factor), Q9JHU5 (Arfaptin 1)."|comment:"Insulin increased GLUT4 interaction with the following proteins:Q9Z1P2 (R-actinin-1), P45592 (Cofilin), Q9QXQ0 (R-actinin-4), P26473 (ADP-ribosylation factor), P26437 (ADP-ribosylation factor),   Q7TNP1 (Basigin 2), Q6P6R2 (Dihydrolipoamide dehydrogenase),   P04797 (GAPDH), Q63081 (Protein disulfide isomerase), P29457 (47 kDa heat shock protein), Q9R1J8 (Leprecan), O88638 (Putative eps protein),   Q64375 (Synaptonemal complex)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:NDPK - Interactions involving proteins containing InterPro domain IPR001564, Nucleoside diphosphate kinase, core.	taxid:10116(rat-l6)|taxid:10116(Rattus norvegicus)	-	2006/02/15	2021/11/30	rogid:PbFY2lfrty8yw40Jq7ShR7xfuV410116	rogid:IvbcUmCiBcTGFn+HmIHGnQRDjeM10116	intact-crc:44F3A2176D02515F|rigid:9RVm0UBcqQF4k06RGKO89Bg16Q8	false	myc tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P19357	uniprotkb:P50408	intact:EBI-915426|uniprotkb:P97900|ensembl:ENSRNOP00000023256	intact:EBI-917679|ensembl:ENSRNOP00000009737	psi-mi:glut4_rat(display_long)|uniprotkb:Glucose transporter type 4, insulin-responsive(gene name synonym)|uniprotkb:Slc2a4(gene name)|psi-mi:Slc2a4(display_short)|uniprotkb:Glut4(gene name synonym)	psi-mi:vatf_rat(display_long)|uniprotkb:Vacuolar proton pump subunit F(gene name synonym)|uniprotkb:V-ATPase 14 kDa subunit(gene name synonym)|uniprotkb:Atp6v1f(gene name)|psi-mi:Atp6v1f(display_short)|uniprotkb:Atp6s14(gene name synonym)|uniprotkb:Vatf(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Foster et al. (2006)	pubmed:16396496|mint:MINT-5218203	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-921030	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2711|refseq:NP_036883.1|refseq:XP_006246658.1|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007611"(learning or memory)|go:"GO:0007614"(short-term memory)|go:"GO:0007616"(long-term memory)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010021"(amylopectin biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031550"(positive regulation of brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044381"(glucose import in response to insulin stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046323"(glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0098694"(regulation of synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0098793"(presynapse)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002441("Glucose transporter, type 4 (GLUT4)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-189200|ensembl:ENSRNOG00000017226(gene)|ensembl:ENSRNOT00000023256(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)	ensembl:ENSRNOG00000007392(gene)|ensembl:ENSRNOT00000009737(transcript)|go:"GO:0016020"(membrane)|go:"GO:0016471"(vacuolar proton-transporting V-type ATPase complex)|go:"GO:0033180"(proton-transporting V-type ATPase, V1 domain)|go:"GO:0042625"(ATPase-coupled ion transmembrane transporter activity)|go:"GO:0046961"(proton-transporting ATPase activity, rotational mechanism)|interpro:IPR005772(ATPase, V1 complex, subunit F, eukaryotic)|interpro:IPR008218(ATPase, V1/A1 complex, subunit F)|interpro:IPR036906|rcsb pdb:6VQ6|rcsb pdb:6VQ7|rcsb pdb:6VQ8|rcsb pdb:6VQC|rcsb pdb:6VQG|rgd:621552|rcsb pdb:6VQH|reactome:R-RNO-1222556|reactome:R-RNO-77387|reactome:R-RNO-917977|reactome:R-RNO-9639288|reactome:R-RNO-983712|refseq:NP_446336.1	-	-	-	caution:"The participant EBI-349571(P68370) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919386(Q7TP47) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920972(Q5XIP9) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-916419(P11980) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919578(Q8R491) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920554(Q5U3Z7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920647(Q5U2X8) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920585(Q7TP24) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-779677(P05426) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-915744(P02454) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|agonist:Insulin was shown to increase or decrease GLUT4 protein interactions in specific cases.|comment:"Insulin decreased GLUT4 interactions with the following proteins: Q9ER30 (Sarcosin), P09527 (Rab-7), O88960 (N-ethylmaleimide sensitive), P09456 (PKA I regulatory subunit), P27881 (Hexokinase type II), P07872 (Acyl-coenzyme A oxidase), Q6DGF1 (Isocitrate dehydrogenase), Q9EQX9 (Ubiquitin-conjugating), Q63446 (Polyubiquitin), P24268 (Cathepsin D), Q91XW0 (Heat shock protein 86), Q5FVH0 (unknown), P58405 (Striatin 3), Q62667 (Major vault protein), Q66H50 (unknown), Q09167 (splicing factor), Q9JHU5 (Arfaptin 1)."|comment:"Insulin increased GLUT4 interaction with the following proteins:Q9Z1P2 (R-actinin-1), P45592 (Cofilin), Q9QXQ0 (R-actinin-4), P26473 (ADP-ribosylation factor), P26437 (ADP-ribosylation factor),   Q7TNP1 (Basigin 2), Q6P6R2 (Dihydrolipoamide dehydrogenase),   P04797 (GAPDH), Q63081 (Protein disulfide isomerase), P29457 (47 kDa heat shock protein), Q9R1J8 (Leprecan), O88638 (Putative eps protein),   Q64375 (Synaptonemal complex)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:NDPK - Interactions involving proteins containing InterPro domain IPR001564, Nucleoside diphosphate kinase, core.	taxid:10116(rat-l6)|taxid:10116(Rattus norvegicus)	-	2006/02/15	2021/11/30	rogid:PbFY2lfrty8yw40Jq7ShR7xfuV410116	rogid:3fcGzehnyb0ieULlCF2CLvnmUhc10116	intact-crc:44F3A2176D02515F|rigid:9RVm0UBcqQF4k06RGKO89Bg16Q8	false	myc tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P19357	uniprotkb:P50137	intact:EBI-915426|uniprotkb:P97900|ensembl:ENSRNOP00000023256	intact:EBI-917670	psi-mi:glut4_rat(display_long)|uniprotkb:Glucose transporter type 4, insulin-responsive(gene name synonym)|uniprotkb:Slc2a4(gene name)|psi-mi:Slc2a4(display_short)|uniprotkb:Glut4(gene name synonym)	psi-mi:tkt_rat(display_long)|uniprotkb:Tkt(gene name)|psi-mi:Tkt(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Foster et al. (2006)	pubmed:16396496|mint:MINT-5218203	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-921030	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2711|refseq:NP_036883.1|refseq:XP_006246658.1|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007611"(learning or memory)|go:"GO:0007614"(short-term memory)|go:"GO:0007616"(long-term memory)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010021"(amylopectin biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031550"(positive regulation of brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044381"(glucose import in response to insulin stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046323"(glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0098694"(regulation of synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0098793"(presynapse)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002441("Glucose transporter, type 4 (GLUT4)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-189200|ensembl:ENSRNOG00000017226(gene)|ensembl:ENSRNOT00000023256(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)	rgd:621036|refseq:NP_072114.1|interpro:IPR009014(Transketolase, C-terminal/Pyruvate-ferredoxin oxidoreductase, domain II)|interpro:IPR005475(Transketolase, central region)|interpro:IPR020826|interpro:IPR005474(Transketolase, N-terminal)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0004802"(transketolase activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005777"(peroxisome)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0006098"(pentose-phosphate shunt)|go:"GO:0009052"(pentose-phosphate shunt, non-oxidative branch)|go:"GO:0030246"(carbohydrate binding)|go:"GO:0030976"(thiamine pyrophosphate binding)|go:"GO:0040008"(regulation of growth)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0046166"(glyceraldehyde-3-phosphate biosynthetic process)|go:"GO:0046390"(ribose phosphate biosynthetic process)|go:"GO:0048029"(monosaccharide binding)|reactome:R-RNO-163754|reactome:R-RNO-71336|interpro:IPR033248|interpro:IPR029061|mint:P50137	-	-	-	caution:"The participant EBI-349571(P68370) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919386(Q7TP47) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920972(Q5XIP9) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-916419(P11980) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919578(Q8R491) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920554(Q5U3Z7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920647(Q5U2X8) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920585(Q7TP24) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-779677(P05426) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-915744(P02454) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|agonist:Insulin was shown to increase or decrease GLUT4 protein interactions in specific cases.|comment:"Insulin decreased GLUT4 interactions with the following proteins: Q9ER30 (Sarcosin), P09527 (Rab-7), O88960 (N-ethylmaleimide sensitive), P09456 (PKA I regulatory subunit), P27881 (Hexokinase type II), P07872 (Acyl-coenzyme A oxidase), Q6DGF1 (Isocitrate dehydrogenase), Q9EQX9 (Ubiquitin-conjugating), Q63446 (Polyubiquitin), P24268 (Cathepsin D), Q91XW0 (Heat shock protein 86), Q5FVH0 (unknown), P58405 (Striatin 3), Q62667 (Major vault protein), Q66H50 (unknown), Q09167 (splicing factor), Q9JHU5 (Arfaptin 1)."|comment:"Insulin increased GLUT4 interaction with the following proteins:Q9Z1P2 (R-actinin-1), P45592 (Cofilin), Q9QXQ0 (R-actinin-4), P26473 (ADP-ribosylation factor), P26437 (ADP-ribosylation factor),   Q7TNP1 (Basigin 2), Q6P6R2 (Dihydrolipoamide dehydrogenase),   P04797 (GAPDH), Q63081 (Protein disulfide isomerase), P29457 (47 kDa heat shock protein), Q9R1J8 (Leprecan), O88638 (Putative eps protein),   Q64375 (Synaptonemal complex)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:NDPK - Interactions involving proteins containing InterPro domain IPR001564, Nucleoside diphosphate kinase, core.	taxid:10116(rat-l6)|taxid:10116(Rattus norvegicus)	-	2006/02/15	2021/11/30	rogid:PbFY2lfrty8yw40Jq7ShR7xfuV410116	rogid:jL5oanYzViy4gIHeeRwno0hfusU10116	intact-crc:44F3A2176D02515F|rigid:9RVm0UBcqQF4k06RGKO89Bg16Q8	false	myc tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P19357	uniprotkb:P49432	intact:EBI-915426|uniprotkb:P97900|ensembl:ENSRNOP00000023256	intact:EBI-917663|uniprotkb:Q6AY95|ensembl:ENSRNOP00000010545	psi-mi:glut4_rat(display_long)|uniprotkb:Glucose transporter type 4, insulin-responsive(gene name synonym)|uniprotkb:Slc2a4(gene name)|psi-mi:Slc2a4(display_short)|uniprotkb:Glut4(gene name synonym)	psi-mi:odpb_rat(display_long)|uniprotkb:Pdhb(gene name)|psi-mi:Pdhb(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Foster et al. (2006)	pubmed:16396496|mint:MINT-5218203	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-921030	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2711|refseq:NP_036883.1|refseq:XP_006246658.1|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007611"(learning or memory)|go:"GO:0007614"(short-term memory)|go:"GO:0007616"(long-term memory)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010021"(amylopectin biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031550"(positive regulation of brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044381"(glucose import in response to insulin stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046323"(glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0098694"(regulation of synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0098793"(presynapse)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002441("Glucose transporter, type 4 (GLUT4)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-189200|ensembl:ENSRNOG00000017226(gene)|ensembl:ENSRNOT00000023256(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)	rgd:1359146|refseq:NP_001007621.1|ensembl:ENSRNOG00000007895(gene)|ensembl:ENSRNOT00000010545(transcript)|go:"GO:0004739"("pyruvate dehydrogenase (acetyl-transferring) activity")|go:"GO:0005739"(mitochondrion)|go:"GO:0005967"(mitochondrial pyruvate dehydrogenase complex)|go:"GO:0006006"(glucose metabolic process)|go:"GO:0006086"(acetyl-CoA biosynthetic process from pyruvate)|go:"GO:0006099"(tricarboxylic acid cycle)|go:"GO:0045254"(pyruvate dehydrogenase complex)|interpro:IPR005475(Transketolase, central region)|interpro:IPR009014(Transketolase, C-terminal/Pyruvate-ferredoxin oxidoreductase, domain II)|interpro:IPR027110|interpro:IPR029061|interpro:IPR033248|mint:P49432|reactome:R-RNO-204174|reactome:R-RNO-389661|reactome:R-RNO-5362517|reactome:R-RNO-70268|refseq:XP_006251816.1	-	-	-	caution:"The participant EBI-349571(P68370) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919386(Q7TP47) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920972(Q5XIP9) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-916419(P11980) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919578(Q8R491) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920554(Q5U3Z7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920647(Q5U2X8) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920585(Q7TP24) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-779677(P05426) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-915744(P02454) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|agonist:Insulin was shown to increase or decrease GLUT4 protein interactions in specific cases.|comment:"Insulin decreased GLUT4 interactions with the following proteins: Q9ER30 (Sarcosin), P09527 (Rab-7), O88960 (N-ethylmaleimide sensitive), P09456 (PKA I regulatory subunit), P27881 (Hexokinase type II), P07872 (Acyl-coenzyme A oxidase), Q6DGF1 (Isocitrate dehydrogenase), Q9EQX9 (Ubiquitin-conjugating), Q63446 (Polyubiquitin), P24268 (Cathepsin D), Q91XW0 (Heat shock protein 86), Q5FVH0 (unknown), P58405 (Striatin 3), Q62667 (Major vault protein), Q66H50 (unknown), Q09167 (splicing factor), Q9JHU5 (Arfaptin 1)."|comment:"Insulin increased GLUT4 interaction with the following proteins:Q9Z1P2 (R-actinin-1), P45592 (Cofilin), Q9QXQ0 (R-actinin-4), P26473 (ADP-ribosylation factor), P26437 (ADP-ribosylation factor),   Q7TNP1 (Basigin 2), Q6P6R2 (Dihydrolipoamide dehydrogenase),   P04797 (GAPDH), Q63081 (Protein disulfide isomerase), P29457 (47 kDa heat shock protein), Q9R1J8 (Leprecan), O88638 (Putative eps protein),   Q64375 (Synaptonemal complex)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:NDPK - Interactions involving proteins containing InterPro domain IPR001564, Nucleoside diphosphate kinase, core.	taxid:10116(rat-l6)|taxid:10116(Rattus norvegicus)	-	2006/02/15	2021/11/30	rogid:PbFY2lfrty8yw40Jq7ShR7xfuV410116	rogid:IauZD1wmQ+/x/0WJZxx7kyX8FT410116	intact-crc:44F3A2176D02515F|rigid:9RVm0UBcqQF4k06RGKO89Bg16Q8	false	myc tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P19357	uniprotkb:P49242	intact:EBI-915426|uniprotkb:P97900|ensembl:ENSRNOP00000023256	intact:EBI-917655|uniprotkb:P33443|ensembl:ENSRNOP00000016329	psi-mi:glut4_rat(display_long)|uniprotkb:Glucose transporter type 4, insulin-responsive(gene name synonym)|uniprotkb:Slc2a4(gene name)|psi-mi:Slc2a4(display_short)|uniprotkb:Glut4(gene name synonym)	psi-mi:rs3a_rat(display_long)|uniprotkb:V-fos transformation effector protein(gene name synonym)|uniprotkb:Rps3a(gene name)|psi-mi:Rps3a(display_short)|uniprotkb:Fte1(gene name synonym)|uniprotkb:Fte-1(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Foster et al. (2006)	pubmed:16396496|mint:MINT-5218203	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-921030	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2711|refseq:NP_036883.1|refseq:XP_006246658.1|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007611"(learning or memory)|go:"GO:0007614"(short-term memory)|go:"GO:0007616"(long-term memory)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010021"(amylopectin biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031550"(positive regulation of brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044381"(glucose import in response to insulin stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046323"(glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0098694"(regulation of synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0098793"(presynapse)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002441("Glucose transporter, type 4 (GLUT4)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-189200|ensembl:ENSRNOG00000017226(gene)|ensembl:ENSRNOT00000023256(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)	rgd:62078|refseq:NP_058849.1|ensembl:ENSRNOG00000011893(gene)|ensembl:ENSRNOT00000016329(transcript)|go:"GO:0003729"(mRNA binding)|go:"GO:0003735"(structural constituent of ribosome)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006412"(translation)|go:"GO:0015935"(small ribosomal subunit)|go:"GO:0022626"(cytosolic ribosome)|go:"GO:0022627"(cytosolic small ribosomal subunit)|go:"GO:0030154"(cell differentiation)|go:"GO:0031369"(translation initiation factor binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0045202"(synapse)|go:"GO:0045471"(response to ethanol)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0048027"(mRNA 5'-UTR binding)|go:"GO:0048146"(positive regulation of fibroblast proliferation)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR001593(Ribosomal protein S3Ae)|interpro:IPR018281|interpro:IPR027500|mint:P49242|reactome:R-RNO-156827|reactome:R-RNO-1799339|reactome:R-RNO-6791226|reactome:R-RNO-72649|reactome:R-RNO-72689|reactome:R-RNO-72695|reactome:R-RNO-72702|reactome:R-RNO-72706|reactome:R-RNO-975956|reactome:R-RNO-975957	-	-	-	caution:"The participant EBI-349571(P68370) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919386(Q7TP47) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920972(Q5XIP9) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-916419(P11980) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919578(Q8R491) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920554(Q5U3Z7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920647(Q5U2X8) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920585(Q7TP24) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-779677(P05426) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-915744(P02454) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|agonist:Insulin was shown to increase or decrease GLUT4 protein interactions in specific cases.|comment:"Insulin decreased GLUT4 interactions with the following proteins: Q9ER30 (Sarcosin), P09527 (Rab-7), O88960 (N-ethylmaleimide sensitive), P09456 (PKA I regulatory subunit), P27881 (Hexokinase type II), P07872 (Acyl-coenzyme A oxidase), Q6DGF1 (Isocitrate dehydrogenase), Q9EQX9 (Ubiquitin-conjugating), Q63446 (Polyubiquitin), P24268 (Cathepsin D), Q91XW0 (Heat shock protein 86), Q5FVH0 (unknown), P58405 (Striatin 3), Q62667 (Major vault protein), Q66H50 (unknown), Q09167 (splicing factor), Q9JHU5 (Arfaptin 1)."|comment:"Insulin increased GLUT4 interaction with the following proteins:Q9Z1P2 (R-actinin-1), P45592 (Cofilin), Q9QXQ0 (R-actinin-4), P26473 (ADP-ribosylation factor), P26437 (ADP-ribosylation factor),   Q7TNP1 (Basigin 2), Q6P6R2 (Dihydrolipoamide dehydrogenase),   P04797 (GAPDH), Q63081 (Protein disulfide isomerase), P29457 (47 kDa heat shock protein), Q9R1J8 (Leprecan), O88638 (Putative eps protein),   Q64375 (Synaptonemal complex)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:NDPK - Interactions involving proteins containing InterPro domain IPR001564, Nucleoside diphosphate kinase, core.	taxid:10116(rat-l6)|taxid:10116(Rattus norvegicus)	-	2006/02/15	2021/11/30	rogid:PbFY2lfrty8yw40Jq7ShR7xfuV410116	rogid:49VqZGeHuN0jq/oCUhMNwhrkVgg10116	intact-crc:44F3A2176D02515F|rigid:9RVm0UBcqQF4k06RGKO89Bg16Q8	false	myc tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P19357	uniprotkb:P49134	intact:EBI-915426|uniprotkb:P97900|ensembl:ENSRNOP00000023256	intact:EBI-917643|uniprotkb:A2RRT8	psi-mi:glut4_rat(display_long)|uniprotkb:Glucose transporter type 4, insulin-responsive(gene name synonym)|uniprotkb:Slc2a4(gene name)|psi-mi:Slc2a4(display_short)|uniprotkb:Glut4(gene name synonym)	psi-mi:itb1_rat(display_long)|uniprotkb:Beta oligodendroglia(gene name synonym)|uniprotkb:Fibronectin receptor subunit beta(gene name synonym)|uniprotkb:VLA-4 subunit beta(gene name synonym)|uniprotkb:Itgb1(gene name)|psi-mi:Itgb1(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Foster et al. (2006)	pubmed:16396496|mint:MINT-5218203	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-921030	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2711|refseq:NP_036883.1|refseq:XP_006246658.1|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007611"(learning or memory)|go:"GO:0007614"(short-term memory)|go:"GO:0007616"(long-term memory)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010021"(amylopectin biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031550"(positive regulation of brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044381"(glucose import in response to insulin stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046323"(glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0098694"(regulation of synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0098793"(presynapse)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002441("Glucose transporter, type 4 (GLUT4)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-189200|ensembl:ENSRNOG00000017226(gene)|ensembl:ENSRNOT00000023256(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)	rgd:2927|refseq:NP_058718.2|interpro:IPR013111(EGF, extracellular)|interpro:IPR015812(Integrin beta subunit)|interpro:IPR014836(Integrin beta subunit, cytoplasmic)|interpro:IPR002369(Integrin beta subunit, N-terminal)|interpro:IPR012896(Integrin beta subunit, tail)|interpro:IPR016201(Plexin-like fold)|interpro:IPR040622|interpro:IPR032695|reactome:R-RNO-9013149|reactome:R-RNO-9013404|reactome:R-RNO-9013408|reactome:R-RNO-9013423|interpro:IPR027071|interpro:IPR033760|interpro:IPR036349|interpro:IPR036465|reactome:R-RNO-1566948|reactome:R-RNO-1566977|reactome:R-RNO-198933|reactome:R-RNO-202733|reactome:R-RNO-210991|reactome:R-RNO-2129379|reactome:R-RNO-216083|reactome:R-RNO-3000157|reactome:R-RNO-3000170|reactome:R-RNO-3000178|reactome:R-RNO-445144|reactome:R-RNO-446343|reactome:R-RNO-8874081|reactome:R-RNO-8875513|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0000132"(establishment of mitotic spindle orientation)|go:"GO:0001669"(acrosomal vesicle)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001708"(cell fate specification)|go:"GO:0001894"(tissue homeostasis)|go:"GO:0001968"(fibronectin binding)|go:"GO:0002020"(protease binding)|go:"GO:0002042"(cell migration involved in sprouting angiogenesis)|go:"GO:0003779"(actin binding)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005518"(collagen binding)|go:"GO:0005604"(basement membrane)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005912"(adherens junction)|go:"GO:0005925"(focal adhesion)|go:"GO:0006909"(phagocytosis)|go:"GO:0007155"(cell adhesion)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007161"(calcium-independent cell-matrix adhesion)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0008277"(regulation of G protein-coupled receptor signaling pathway)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008305"(integrin complex)|go:"GO:0008354"(germ cell migration)|go:"GO:0008542"(visual learning)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010710"(regulation of collagen catabolic process)|go:"GO:0010763"(positive regulation of fibroblast migration)|go:"GO:0010811"(positive regulation of cell-substrate adhesion)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0014704"(intercalated disc)|go:"GO:0014823"(response to activity)|go:"GO:0016020"(membrane)|go:"GO:0016477"(cell migration)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0021943"(formation of radial glial scaffolds)|go:"GO:0023035"(CD40 signaling pathway)|go:"GO:0030027"(lamellipodium)|go:"GO:0030030"(cell projection organization)|go:"GO:0030032"(lamellipodium assembly)|go:"GO:0030056"(hemidesmosome)|go:"GO:0030175"(filopodium)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0031175"(neuron projection development)|go:"GO:0031345"(negative regulation of cell projection organization)|go:"GO:0031589"(cell-substrate adhesion)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031623"(receptor internalization)|go:"GO:0031667"(response to nutrient levels)|go:"GO:0032587"(ruffle membrane)|go:"GO:0032594"(protein transport within lipid bilayer)|go:"GO:0033627"(cell adhesion mediated by integrin)|go:"GO:0033631"(cell-cell adhesion mediated by integrin)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0034665"(integrin alpha1-beta1 complex)|go:"GO:0034666"(integrin alpha2-beta1 complex)|go:"GO:0034667"(integrin alpha3-beta1 complex)|go:"GO:0034674"(integrin alpha5-beta1 complex)|go:"GO:0034677"(integrin alpha7-beta1 complex)|go:"GO:0034679"(integrin alpha9-beta1 complex)|go:"GO:0034680"(integrin alpha10-beta1 complex)|go:"GO:0034681"(integrin alpha11-beta1 complex)|go:"GO:0034698"(response to gonadotropin)|go:"GO:0035024"(negative regulation of Rho protein signal transduction)|go:"GO:0035748"(myelin sheath abaxonal region)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042383"(sarcolemma)|go:"GO:0042470"(melanosome)|go:"GO:0042493"|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043197"(dendritic spine)|go:"GO:0043235"(receptor complex)|go:"GO:0043236"(laminin binding)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045121"(membrane raft)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045214"(sarcomere organization)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0045666"(positive regulation of neuron differentiation)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0045807"(positive regulation of endocytosis)|go:"GO:0046872"(metal ion binding)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048333"(mesodermal cell differentiation)|go:"GO:0048675"(axon extension)|go:"GO:0048813"(dendrite morphogenesis)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0051393"(alpha-actinin binding)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0051951"(positive regulation of glutamate uptake involved in transmission of nerve impulse)|go:"GO:0055007"(cardiac muscle cell differentiation)|go:"GO:0055037"(recycling endosome)|go:"GO:0060135"(maternal process involved in female pregnancy)|go:"GO:0070830"(bicellular tight junction assembly)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071305"(cellular response to vitamin D)|go:"GO:0071404"(cellular response to low-density lipoprotein particle stimulus)|go:"GO:0071479"(cellular response to ionizing radiation)|go:"GO:0071559"(response to transforming growth factor beta)|go:"GO:0071711"(basement membrane organization)|go:"GO:0090303"(positive regulation of wound healing)|go:"GO:0097060"(synaptic membrane)|go:"GO:0097368"(establishment of Sertoli cell barrier)|go:"GO:0097386"(glial cell projection)|go:"GO:0098639"(collagen binding involved in cell-matrix adhesion)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099055"(integral component of postsynaptic membrane)|go:"GO:0099561"(synaptic membrane adhesion to extracellular matrix)|go:"GO:0099699"(integral component of synaptic membrane)|go:"GO:0150003"(regulation of spontaneous synaptic transmission)|go:"GO:0150103"(reactive gliosis)|go:"GO:1901979"(regulation of inward rectifier potassium channel activity)|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|go:"GO:1990782"(protein tyrosine kinase binding)|go:"GO:2000273"(positive regulation of signaling receptor activity)|go:"GO:2000811"(negative regulation of anoikis)	-	-	-	caution:"The participant EBI-349571(P68370) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919386(Q7TP47) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920972(Q5XIP9) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-916419(P11980) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919578(Q8R491) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920554(Q5U3Z7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920647(Q5U2X8) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920585(Q7TP24) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-779677(P05426) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-915744(P02454) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|agonist:Insulin was shown to increase or decrease GLUT4 protein interactions in specific cases.|comment:"Insulin decreased GLUT4 interactions with the following proteins: Q9ER30 (Sarcosin), P09527 (Rab-7), O88960 (N-ethylmaleimide sensitive), P09456 (PKA I regulatory subunit), P27881 (Hexokinase type II), P07872 (Acyl-coenzyme A oxidase), Q6DGF1 (Isocitrate dehydrogenase), Q9EQX9 (Ubiquitin-conjugating), Q63446 (Polyubiquitin), P24268 (Cathepsin D), Q91XW0 (Heat shock protein 86), Q5FVH0 (unknown), P58405 (Striatin 3), Q62667 (Major vault protein), Q66H50 (unknown), Q09167 (splicing factor), Q9JHU5 (Arfaptin 1)."|comment:"Insulin increased GLUT4 interaction with the following proteins:Q9Z1P2 (R-actinin-1), P45592 (Cofilin), Q9QXQ0 (R-actinin-4), P26473 (ADP-ribosylation factor), P26437 (ADP-ribosylation factor),   Q7TNP1 (Basigin 2), Q6P6R2 (Dihydrolipoamide dehydrogenase),   P04797 (GAPDH), Q63081 (Protein disulfide isomerase), P29457 (47 kDa heat shock protein), Q9R1J8 (Leprecan), O88638 (Putative eps protein),   Q64375 (Synaptonemal complex)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:NDPK - Interactions involving proteins containing InterPro domain IPR001564, Nucleoside diphosphate kinase, core.	taxid:10116(rat-l6)|taxid:10116(Rattus norvegicus)	-	2006/02/15	2021/11/30	rogid:PbFY2lfrty8yw40Jq7ShR7xfuV410116	rogid:PIKSmfsy+kdpKCSAjybmyoZzTZ810116	intact-crc:44F3A2176D02515F|rigid:9RVm0UBcqQF4k06RGKO89Bg16Q8	false	myc tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P19357	uniprotkb:P48721	intact:EBI-915426|uniprotkb:P97900|ensembl:ENSRNOP00000023256	intact:EBI-917635	psi-mi:glut4_rat(display_long)|uniprotkb:Glucose transporter type 4, insulin-responsive(gene name synonym)|uniprotkb:Slc2a4(gene name)|psi-mi:Slc2a4(display_short)|uniprotkb:Glut4(gene name synonym)	psi-mi:grp75_rat(display_long)|uniprotkb:75 kDa glucose-regulated protein(gene name synonym)|uniprotkb:Heat shock 70 kDa protein 9(gene name synonym)|uniprotkb:Peptide-binding protein 74(gene name synonym)|uniprotkb:mtHSP70(gene name synonym)|uniprotkb:Mortalin(gene name synonym)|uniprotkb:Hspa9(gene name)|psi-mi:Hspa9(display_short)|uniprotkb:Grp75(gene name synonym)|uniprotkb:Hspa9a(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Foster et al. (2006)	pubmed:16396496|mint:MINT-5218203	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-921030	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2711|refseq:NP_036883.1|refseq:XP_006246658.1|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007611"(learning or memory)|go:"GO:0007614"(short-term memory)|go:"GO:0007616"(long-term memory)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010021"(amylopectin biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031550"(positive regulation of brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044381"(glucose import in response to insulin stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046323"(glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0098694"(regulation of synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0098793"(presynapse)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002441("Glucose transporter, type 4 (GLUT4)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-189200|ensembl:ENSRNOG00000017226(gene)|ensembl:ENSRNOT00000023256(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)	rgd:1311806|interpro:IPR012725(Chaperone DnaK)|interpro:IPR018181|interpro:IPR013126(Heat shock protein 70)|interpro:IPR043129|interpro:IPR029047|interpro:IPR029048|mint:P48721|go:"GO:0005524"(ATP binding)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0006611"(protein export from nucleus)|go:"GO:0009636"(response to toxic substance)|go:"GO:0016226"(iron-sulfur cluster assembly)|go:"GO:0017134"(fibroblast growth factor binding)|go:"GO:0019899"(enzyme binding)|go:"GO:0030218"(erythrocyte differentiation)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0034620"(cellular response to unfolded protein)|go:"GO:0042026"(protein refolding)|go:"GO:0042645"(mitochondrial nucleoid)|go:"GO:0044183"(protein folding chaperone)|go:"GO:0045646"(regulation of erythrocyte differentiation)|go:"GO:0045647"(negative regulation of erythrocyte differentiation)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051085"(chaperone cofactor-dependent protein refolding)|go:"GO:0051087"(chaperone binding)|go:"GO:0051593"(response to folic acid)|go:"GO:0051787"(misfolded protein binding)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0097068"(response to thyroxine)|go:"GO:1902037"(negative regulation of hematopoietic stem cell differentiation)|go:"GO:1903707"(negative regulation of hemopoiesis)|reactome:R-RNO-3371453	-	-	-	caution:"The participant EBI-349571(P68370) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919386(Q7TP47) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920972(Q5XIP9) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-916419(P11980) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919578(Q8R491) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920554(Q5U3Z7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920647(Q5U2X8) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920585(Q7TP24) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-779677(P05426) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-915744(P02454) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|agonist:Insulin was shown to increase or decrease GLUT4 protein interactions in specific cases.|comment:"Insulin decreased GLUT4 interactions with the following proteins: Q9ER30 (Sarcosin), P09527 (Rab-7), O88960 (N-ethylmaleimide sensitive), P09456 (PKA I regulatory subunit), P27881 (Hexokinase type II), P07872 (Acyl-coenzyme A oxidase), Q6DGF1 (Isocitrate dehydrogenase), Q9EQX9 (Ubiquitin-conjugating), Q63446 (Polyubiquitin), P24268 (Cathepsin D), Q91XW0 (Heat shock protein 86), Q5FVH0 (unknown), P58405 (Striatin 3), Q62667 (Major vault protein), Q66H50 (unknown), Q09167 (splicing factor), Q9JHU5 (Arfaptin 1)."|comment:"Insulin increased GLUT4 interaction with the following proteins:Q9Z1P2 (R-actinin-1), P45592 (Cofilin), Q9QXQ0 (R-actinin-4), P26473 (ADP-ribosylation factor), P26437 (ADP-ribosylation factor),   Q7TNP1 (Basigin 2), Q6P6R2 (Dihydrolipoamide dehydrogenase),   P04797 (GAPDH), Q63081 (Protein disulfide isomerase), P29457 (47 kDa heat shock protein), Q9R1J8 (Leprecan), O88638 (Putative eps protein),   Q64375 (Synaptonemal complex)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:NDPK - Interactions involving proteins containing InterPro domain IPR001564, Nucleoside diphosphate kinase, core.	taxid:10116(rat-l6)|taxid:10116(Rattus norvegicus)	-	2006/02/15	2021/11/30	rogid:PbFY2lfrty8yw40Jq7ShR7xfuV410116	rogid:AjNsAzoqHp4Ajc/n+1q7R4XnYOg10116	intact-crc:44F3A2176D02515F|rigid:9RVm0UBcqQF4k06RGKO89Bg16Q8	false	myc tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P19357	uniprotkb:P48679	intact:EBI-915426|uniprotkb:P97900|ensembl:ENSRNOP00000023256	intact:EBI-917618	psi-mi:glut4_rat(display_long)|uniprotkb:Glucose transporter type 4, insulin-responsive(gene name synonym)|uniprotkb:Slc2a4(gene name)|psi-mi:Slc2a4(display_short)|uniprotkb:Glut4(gene name synonym)	psi-mi:lmna_rat(display_long)|uniprotkb:Lmna(gene name)|psi-mi:Lmna(display_short)|uniprotkb:Lmn1(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Foster et al. (2006)	pubmed:16396496|mint:MINT-5218203	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-921030	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2711|refseq:NP_036883.1|refseq:XP_006246658.1|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007611"(learning or memory)|go:"GO:0007614"(short-term memory)|go:"GO:0007616"(long-term memory)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010021"(amylopectin biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031550"(positive regulation of brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044381"(glucose import in response to insulin stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046323"(glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0098694"(regulation of synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0098793"(presynapse)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002441("Glucose transporter, type 4 (GLUT4)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-189200|ensembl:ENSRNOG00000017226(gene)|ensembl:ENSRNOT00000023256(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)	rgd:620456|interpro:IPR001322(Intermediate filament, C-terminal)|interpro:IPR018039|mint:P48679|interpro:IPR039008|interpro:IPR036415|go:"GO:0005634"(nucleus)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005638"(lamin filament)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0006997"(nucleus organization)|go:"GO:0006998"(nuclear envelope organization)|go:"GO:0007283"(spermatogenesis)|go:"GO:0008157"(protein phosphatase 1 binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009612"(response to mechanical stimulus)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016363"(nuclear matrix)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0030951"(establishment or maintenance of microtubule cytoskeleton polarity)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0031965"(nuclear membrane)|go:"GO:0034504"(protein localization to nucleus)|go:"GO:0035861"(site of double-strand break)|go:"GO:0045669"(positive regulation of osteoblast differentiation)|go:"GO:0055015"(ventricular cardiac muscle cell development)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0072201"(negative regulation of mesenchymal cell proliferation)|go:"GO:0090201"(negative regulation of release of cytochrome c from mitochondria)|go:"GO:0090343"(positive regulation of cell aging)|go:"GO:0090398"(cellular senescence)|go:"GO:1900114"(positive regulation of histone H3-K9 trimethylation)|go:"GO:1900180"(regulation of protein localization to nucleus)|go:"GO:1903243"(negative regulation of cardiac muscle hypertrophy in response to stress)|go:"GO:1904178"(negative regulation of adipose tissue development)|go:"GO:1990683"(DNA double-strand break attachment to nuclear envelope)|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway)|reactome:R-RNO-352238|reactome:R-RNO-4419969	-	-	-	caution:"The participant EBI-349571(P68370) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919386(Q7TP47) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920972(Q5XIP9) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-916419(P11980) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919578(Q8R491) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920554(Q5U3Z7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920647(Q5U2X8) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920585(Q7TP24) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-779677(P05426) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-915744(P02454) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|agonist:Insulin was shown to increase or decrease GLUT4 protein interactions in specific cases.|comment:"Insulin decreased GLUT4 interactions with the following proteins: Q9ER30 (Sarcosin), P09527 (Rab-7), O88960 (N-ethylmaleimide sensitive), P09456 (PKA I regulatory subunit), P27881 (Hexokinase type II), P07872 (Acyl-coenzyme A oxidase), Q6DGF1 (Isocitrate dehydrogenase), Q9EQX9 (Ubiquitin-conjugating), Q63446 (Polyubiquitin), P24268 (Cathepsin D), Q91XW0 (Heat shock protein 86), Q5FVH0 (unknown), P58405 (Striatin 3), Q62667 (Major vault protein), Q66H50 (unknown), Q09167 (splicing factor), Q9JHU5 (Arfaptin 1)."|comment:"Insulin increased GLUT4 interaction with the following proteins:Q9Z1P2 (R-actinin-1), P45592 (Cofilin), Q9QXQ0 (R-actinin-4), P26473 (ADP-ribosylation factor), P26437 (ADP-ribosylation factor),   Q7TNP1 (Basigin 2), Q6P6R2 (Dihydrolipoamide dehydrogenase),   P04797 (GAPDH), Q63081 (Protein disulfide isomerase), P29457 (47 kDa heat shock protein), Q9R1J8 (Leprecan), O88638 (Putative eps protein),   Q64375 (Synaptonemal complex)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:NDPK - Interactions involving proteins containing InterPro domain IPR001564, Nucleoside diphosphate kinase, core.	taxid:10116(rat-l6)|taxid:10116(Rattus norvegicus)	-	2006/02/15	2021/11/30	rogid:PbFY2lfrty8yw40Jq7ShR7xfuV410116	rogid:WBZq/9WdHqQmDRy0uyBn0AZjvY810116	intact-crc:44F3A2176D02515F|rigid:9RVm0UBcqQF4k06RGKO89Bg16Q8	false	myc tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P19357	uniprotkb:P48675	intact:EBI-915426|uniprotkb:P97900|ensembl:ENSRNOP00000023256	intact:EBI-917611	psi-mi:glut4_rat(display_long)|uniprotkb:Glucose transporter type 4, insulin-responsive(gene name synonym)|uniprotkb:Slc2a4(gene name)|psi-mi:Slc2a4(display_short)|uniprotkb:Glut4(gene name synonym)	psi-mi:desm_rat(display_long)|uniprotkb:Des(gene name)|psi-mi:Des(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Foster et al. (2006)	pubmed:16396496|mint:MINT-5218203	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-921030	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2711|refseq:NP_036883.1|refseq:XP_006246658.1|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007611"(learning or memory)|go:"GO:0007614"(short-term memory)|go:"GO:0007616"(long-term memory)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010021"(amylopectin biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031550"(positive regulation of brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044381"(glucose import in response to insulin stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046323"(glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0098694"(regulation of synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0098793"(presynapse)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002441("Glucose transporter, type 4 (GLUT4)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-189200|ensembl:ENSRNOG00000017226(gene)|ensembl:ENSRNOT00000023256(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)	interpro:IPR039008|rgd:620686|refseq:NP_071976.1|interpro:IPR006821(Intermediate filament, DNA-binding region)|interpro:IPR018039|reactome:R-RNO-390522|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005916"(fascia adherens)|go:"GO:0005921"(gap junction)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0014704"(intercalated disc)|go:"GO:0030018"(Z disc)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0042383"(sarcolemma)|go:"GO:0042802"(identical protein binding)|go:"GO:0043292"(contractile fiber)|go:"GO:0045098"(type III intermediate filament)|go:"GO:0045109"(intermediate filament organization)|go:"GO:0097512"(cardiac myofibril)	-	-	-	caution:"The participant EBI-349571(P68370) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919386(Q7TP47) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920972(Q5XIP9) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-916419(P11980) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919578(Q8R491) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920554(Q5U3Z7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920647(Q5U2X8) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920585(Q7TP24) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-779677(P05426) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-915744(P02454) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|agonist:Insulin was shown to increase or decrease GLUT4 protein interactions in specific cases.|comment:"Insulin decreased GLUT4 interactions with the following proteins: Q9ER30 (Sarcosin), P09527 (Rab-7), O88960 (N-ethylmaleimide sensitive), P09456 (PKA I regulatory subunit), P27881 (Hexokinase type II), P07872 (Acyl-coenzyme A oxidase), Q6DGF1 (Isocitrate dehydrogenase), Q9EQX9 (Ubiquitin-conjugating), Q63446 (Polyubiquitin), P24268 (Cathepsin D), Q91XW0 (Heat shock protein 86), Q5FVH0 (unknown), P58405 (Striatin 3), Q62667 (Major vault protein), Q66H50 (unknown), Q09167 (splicing factor), Q9JHU5 (Arfaptin 1)."|comment:"Insulin increased GLUT4 interaction with the following proteins:Q9Z1P2 (R-actinin-1), P45592 (Cofilin), Q9QXQ0 (R-actinin-4), P26473 (ADP-ribosylation factor), P26437 (ADP-ribosylation factor),   Q7TNP1 (Basigin 2), Q6P6R2 (Dihydrolipoamide dehydrogenase),   P04797 (GAPDH), Q63081 (Protein disulfide isomerase), P29457 (47 kDa heat shock protein), Q9R1J8 (Leprecan), O88638 (Putative eps protein),   Q64375 (Synaptonemal complex)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:NDPK - Interactions involving proteins containing InterPro domain IPR001564, Nucleoside diphosphate kinase, core.	taxid:10116(rat-l6)|taxid:10116(Rattus norvegicus)	-	2006/02/15	2021/11/30	rogid:PbFY2lfrty8yw40Jq7ShR7xfuV410116	rogid:28nwNWVR78n52KyhEAEHZ8W0E2U10116	intact-crc:44F3A2176D02515F|rigid:9RVm0UBcqQF4k06RGKO89Bg16Q8	false	myc tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P19357	uniprotkb:P48500	intact:EBI-915426|uniprotkb:P97900|ensembl:ENSRNOP00000023256	intact:EBI-917606|uniprotkb:A0JN18|uniprotkb:Q6P793|ensembl:ENSRNOP00000020647|ensembl:ENSRNOP00000067409	psi-mi:glut4_rat(display_long)|uniprotkb:Glucose transporter type 4, insulin-responsive(gene name synonym)|uniprotkb:Slc2a4(gene name)|psi-mi:Slc2a4(display_short)|uniprotkb:Glut4(gene name synonym)	psi-mi:tpis_rat(display_long)|uniprotkb:Triose-phosphate isomerase(gene name synonym)|uniprotkb:Tpi1(gene name)|psi-mi:Tpi1(display_short)|uniprotkb:Methylglyoxal synthase(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Foster et al. (2006)	pubmed:16396496|mint:MINT-5218203	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-921030	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2711|refseq:NP_036883.1|refseq:XP_006246658.1|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007611"(learning or memory)|go:"GO:0007614"(short-term memory)|go:"GO:0007616"(long-term memory)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010021"(amylopectin biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031550"(positive regulation of brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044381"(glucose import in response to insulin stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046323"(glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0098694"(regulation of synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0098793"(presynapse)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002441("Glucose transporter, type 4 (GLUT4)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-189200|ensembl:ENSRNOG00000017226(gene)|ensembl:ENSRNOT00000023256(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)	rgd:3896|refseq:NP_075211.2|ensembl:ENSRNOG00000015290(gene)|ensembl:ENSRNOG00000050669(gene)|ensembl:ENSRNOT00000020647(transcript)|ensembl:ENSRNOT00000071439(transcript)|go:"GO:0004807"(triose-phosphate isomerase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0005975"(carbohydrate metabolic process)|go:"GO:0006006"(glucose metabolic process)|go:"GO:0006094"(gluconeogenesis)|go:"GO:0006096"(glycolytic process)|go:"GO:0008929"(methylglyoxal synthase activity)|go:"GO:0016853"(isomerase activity)|go:"GO:0019242"(methylglyoxal biosynthetic process)|go:"GO:0019563"(glycerol catabolic process)|go:"GO:0019682"(glyceraldehyde-3-phosphate metabolic process)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0046166"(glyceraldehyde-3-phosphate biosynthetic process)|interpro:IPR000652(Triosephosphate isomerase)|interpro:IPR013785(Aldolase-type TIM barrel)|interpro:IPR020861|interpro:IPR022896|interpro:IPR035990|mint:P48500|reactome:R-RNO-70171|reactome:R-RNO-70263	-	-	-	caution:"The participant EBI-349571(P68370) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919386(Q7TP47) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920972(Q5XIP9) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-916419(P11980) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919578(Q8R491) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920554(Q5U3Z7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920647(Q5U2X8) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920585(Q7TP24) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-779677(P05426) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-915744(P02454) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|agonist:Insulin was shown to increase or decrease GLUT4 protein interactions in specific cases.|comment:"Insulin decreased GLUT4 interactions with the following proteins: Q9ER30 (Sarcosin), P09527 (Rab-7), O88960 (N-ethylmaleimide sensitive), P09456 (PKA I regulatory subunit), P27881 (Hexokinase type II), P07872 (Acyl-coenzyme A oxidase), Q6DGF1 (Isocitrate dehydrogenase), Q9EQX9 (Ubiquitin-conjugating), Q63446 (Polyubiquitin), P24268 (Cathepsin D), Q91XW0 (Heat shock protein 86), Q5FVH0 (unknown), P58405 (Striatin 3), Q62667 (Major vault protein), Q66H50 (unknown), Q09167 (splicing factor), Q9JHU5 (Arfaptin 1)."|comment:"Insulin increased GLUT4 interaction with the following proteins:Q9Z1P2 (R-actinin-1), P45592 (Cofilin), Q9QXQ0 (R-actinin-4), P26473 (ADP-ribosylation factor), P26437 (ADP-ribosylation factor),   Q7TNP1 (Basigin 2), Q6P6R2 (Dihydrolipoamide dehydrogenase),   P04797 (GAPDH), Q63081 (Protein disulfide isomerase), P29457 (47 kDa heat shock protein), Q9R1J8 (Leprecan), O88638 (Putative eps protein),   Q64375 (Synaptonemal complex)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:NDPK - Interactions involving proteins containing InterPro domain IPR001564, Nucleoside diphosphate kinase, core.	taxid:10116(rat-l6)|taxid:10116(Rattus norvegicus)	-	2006/02/15	2021/11/30	rogid:PbFY2lfrty8yw40Jq7ShR7xfuV410116	rogid:W10iJfxiYxwYl5C2aji6DCDhpBc10116	intact-crc:44F3A2176D02515F|rigid:9RVm0UBcqQF4k06RGKO89Bg16Q8	false	myc tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P19357	uniprotkb:P48037	intact:EBI-915426|uniprotkb:P97900|ensembl:ENSRNOP00000023256	intact:EBI-917595	psi-mi:glut4_rat(display_long)|uniprotkb:Glucose transporter type 4, insulin-responsive(gene name synonym)|uniprotkb:Slc2a4(gene name)|psi-mi:Slc2a4(display_short)|uniprotkb:Glut4(gene name synonym)	psi-mi:anxa6_rat(display_long)|uniprotkb:Annexin-6(gene name synonym)|uniprotkb:Annexin VI(gene name synonym)|uniprotkb:Calcium-binding protein 65/67(gene name synonym)|uniprotkb:Anxa6(gene name)|psi-mi:Anxa6(display_short)|uniprotkb:Anx6(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Foster et al. (2006)	pubmed:16396496|mint:MINT-5218203	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-921030	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2711|refseq:NP_036883.1|refseq:XP_006246658.1|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007611"(learning or memory)|go:"GO:0007614"(short-term memory)|go:"GO:0007616"(long-term memory)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010021"(amylopectin biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031550"(positive regulation of brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044381"(glucose import in response to insulin stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046323"(glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0098694"(regulation of synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0098793"(presynapse)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002441("Glucose transporter, type 4 (GLUT4)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-189200|ensembl:ENSRNOG00000017226(gene)|ensembl:ENSRNOT00000023256(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)	rgd:621172|interpro:IPR001464(Annexin)|interpro:IPR018502|interpro:IPR018252|interpro:IPR002393(Annexin, type VI)|interpro:IPR037104|go:"GO:0001755"(neural crest cell migration)|go:"GO:0001778"(plasma membrane repair)|go:"GO:0001786"(phosphatidylserine binding)|go:"GO:0003418"(growth plate cartilage chondrocyte differentiation)|go:"GO:0005262"(calcium channel activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005525"(GTP binding)|go:"GO:0005544"(calcium-dependent phospholipid binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006937"(regulation of muscle contraction)|go:"GO:0008289"(lipid binding)|go:"GO:0014704"(intercalated disc)|go:"GO:0015276"(ligand-gated ion channel activity)|go:"GO:0015485"(cholesterol binding)|go:"GO:0016020"(membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0031902"(late endosome membrane)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034220"(ion transmembrane transport)|go:"GO:0035374"(chondroitin sulfate binding)|go:"GO:0042383"(sarcolemma)|go:"GO:0042470"(melanosome)|go:"GO:0042802"(identical protein binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046903"(secretion)|go:"GO:0048306"(calcium-dependent protein binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051015"(actin filament binding)|go:"GO:0051283"(negative regulation of sequestering of calcium ion)|go:"GO:0051560"(mitochondrial calcium ion homeostasis)|go:"GO:0097190"(apoptotic signaling pathway)	-	-	-	caution:"The participant EBI-349571(P68370) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919386(Q7TP47) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920972(Q5XIP9) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-916419(P11980) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919578(Q8R491) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920554(Q5U3Z7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920647(Q5U2X8) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920585(Q7TP24) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-779677(P05426) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-915744(P02454) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|agonist:Insulin was shown to increase or decrease GLUT4 protein interactions in specific cases.|comment:"Insulin decreased GLUT4 interactions with the following proteins: Q9ER30 (Sarcosin), P09527 (Rab-7), O88960 (N-ethylmaleimide sensitive), P09456 (PKA I regulatory subunit), P27881 (Hexokinase type II), P07872 (Acyl-coenzyme A oxidase), Q6DGF1 (Isocitrate dehydrogenase), Q9EQX9 (Ubiquitin-conjugating), Q63446 (Polyubiquitin), P24268 (Cathepsin D), Q91XW0 (Heat shock protein 86), Q5FVH0 (unknown), P58405 (Striatin 3), Q62667 (Major vault protein), Q66H50 (unknown), Q09167 (splicing factor), Q9JHU5 (Arfaptin 1)."|comment:"Insulin increased GLUT4 interaction with the following proteins:Q9Z1P2 (R-actinin-1), P45592 (Cofilin), Q9QXQ0 (R-actinin-4), P26473 (ADP-ribosylation factor), P26437 (ADP-ribosylation factor),   Q7TNP1 (Basigin 2), Q6P6R2 (Dihydrolipoamide dehydrogenase),   P04797 (GAPDH), Q63081 (Protein disulfide isomerase), P29457 (47 kDa heat shock protein), Q9R1J8 (Leprecan), O88638 (Putative eps protein),   Q64375 (Synaptonemal complex)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:NDPK - Interactions involving proteins containing InterPro domain IPR001564, Nucleoside diphosphate kinase, core.	taxid:10116(rat-l6)|taxid:10116(Rattus norvegicus)	-	2006/02/15	2021/11/30	rogid:PbFY2lfrty8yw40Jq7ShR7xfuV410116	rogid:hWGMXJuio4/6/NDpkmRIDicrcbk10116	intact-crc:44F3A2176D02515F|rigid:9RVm0UBcqQF4k06RGKO89Bg16Q8	false	myc tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P19357	uniprotkb:P48004	intact:EBI-915426|uniprotkb:P97900|ensembl:ENSRNOP00000023256	intact:EBI-917581	psi-mi:glut4_rat(display_long)|uniprotkb:Glucose transporter type 4, insulin-responsive(gene name synonym)|uniprotkb:Slc2a4(gene name)|psi-mi:Slc2a4(display_short)|uniprotkb:Glut4(gene name synonym)	psi-mi:psa7_rat(display_long)|uniprotkb:Proteasome subunit RC6-1(gene name synonym)|uniprotkb:Psma7(gene name)|psi-mi:Psma7(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Foster et al. (2006)	pubmed:16396496|mint:MINT-5218203	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-921030	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2711|refseq:NP_036883.1|refseq:XP_006246658.1|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007611"(learning or memory)|go:"GO:0007614"(short-term memory)|go:"GO:0007616"(long-term memory)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010021"(amylopectin biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031550"(positive regulation of brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044381"(glucose import in response to insulin stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046323"(glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0098694"(regulation of synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0098793"(presynapse)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002441("Glucose transporter, type 4 (GLUT4)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-189200|ensembl:ENSRNOG00000017226(gene)|ensembl:ENSRNOT00000023256(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)	rgd:61851|interpro:IPR000426(Proteasome alpha-subunit, conserved site)|interpro:IPR023332|interpro:IPR001353(20S proteasome, A and B subunits)|reactome:R-RNO-8932339|interpro:IPR029055|rcsb pdb:6EPC|rcsb pdb:6EPD|rcsb pdb:6EPE|rcsb pdb:6EPF|interpro:IPR035190|reactome:R-RNO-174084|reactome:R-RNO-5689603|reactome:R-RNO-5689880|reactome:R-RNO-68827|reactome:R-RNO-8951664|reactome:R-RNO-1169091|reactome:R-RNO-1234176|reactome:R-RNO-1236978|reactome:R-RNO-174154|reactome:R-RNO-174178|reactome:R-RNO-174184|reactome:R-RNO-187577|reactome:R-RNO-195253|reactome:R-RNO-2467813|reactome:R-RNO-349425|reactome:R-RNO-350562|reactome:R-RNO-382556|reactome:R-RNO-450408|reactome:R-RNO-4608870|reactome:R-RNO-4641257|reactome:R-RNO-4641258|reactome:R-RNO-5358346|reactome:R-RNO-5607761|reactome:R-RNO-5610780|reactome:R-RNO-5610785|reactome:R-RNO-5632684|reactome:R-RNO-5658442|reactome:R-RNO-5668541|reactome:R-RNO-5676590|reactome:R-RNO-5687128|reactome:R-RNO-68949|reactome:R-RNO-69017|reactome:R-RNO-69481|reactome:R-RNO-69601|reactome:R-RNO-75815|reactome:R-RNO-8852276|reactome:R-RNO-8854050|reactome:R-RNO-8939236|reactome:R-RNO-8941858|reactome:R-RNO-8948751|reactome:R-RNO-983168|rcsb pdb:6TU3|go:"GO:0000502"(proteasome complex)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005839"(proteasome core complex)|go:"GO:0010499"(proteasomal ubiquitin-independent protein catabolic process)|go:"GO:0019773"(proteasome core complex, alpha-subunit complex)|go:"GO:0042802"(identical protein binding)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0098794"(postsynapse)	-	-	-	caution:"The participant EBI-349571(P68370) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919386(Q7TP47) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920972(Q5XIP9) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-916419(P11980) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919578(Q8R491) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920554(Q5U3Z7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920647(Q5U2X8) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920585(Q7TP24) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-779677(P05426) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-915744(P02454) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|agonist:Insulin was shown to increase or decrease GLUT4 protein interactions in specific cases.|comment:"Insulin decreased GLUT4 interactions with the following proteins: Q9ER30 (Sarcosin), P09527 (Rab-7), O88960 (N-ethylmaleimide sensitive), P09456 (PKA I regulatory subunit), P27881 (Hexokinase type II), P07872 (Acyl-coenzyme A oxidase), Q6DGF1 (Isocitrate dehydrogenase), Q9EQX9 (Ubiquitin-conjugating), Q63446 (Polyubiquitin), P24268 (Cathepsin D), Q91XW0 (Heat shock protein 86), Q5FVH0 (unknown), P58405 (Striatin 3), Q62667 (Major vault protein), Q66H50 (unknown), Q09167 (splicing factor), Q9JHU5 (Arfaptin 1)."|comment:"Insulin increased GLUT4 interaction with the following proteins:Q9Z1P2 (R-actinin-1), P45592 (Cofilin), Q9QXQ0 (R-actinin-4), P26473 (ADP-ribosylation factor), P26437 (ADP-ribosylation factor),   Q7TNP1 (Basigin 2), Q6P6R2 (Dihydrolipoamide dehydrogenase),   P04797 (GAPDH), Q63081 (Protein disulfide isomerase), P29457 (47 kDa heat shock protein), Q9R1J8 (Leprecan), O88638 (Putative eps protein),   Q64375 (Synaptonemal complex)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:NDPK - Interactions involving proteins containing InterPro domain IPR001564, Nucleoside diphosphate kinase, core.	taxid:10116(rat-l6)|taxid:10116(Rattus norvegicus)	-	2006/02/15	2021/11/30	rogid:PbFY2lfrty8yw40Jq7ShR7xfuV410116	rogid:In4yx2CtUgSGzS6Bw+PMORHA4SY10116	intact-crc:44F3A2176D02515F|rigid:9RVm0UBcqQF4k06RGKO89Bg16Q8	false	myc tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P19357	uniprotkb:P47942	intact:EBI-915426|uniprotkb:P97900|ensembl:ENSRNOP00000023256	intact:EBI-917570|intact:EBI-6096016|ensembl:ENSRNOP00000012996	psi-mi:glut4_rat(display_long)|uniprotkb:Glucose transporter type 4, insulin-responsive(gene name synonym)|uniprotkb:Slc2a4(gene name)|psi-mi:Slc2a4(display_short)|uniprotkb:Glut4(gene name synonym)	psi-mi:dpyl2_rat(display_long)|uniprotkb:Turned on after division 64 kDa protein(gene name synonym)|uniprotkb:Collapsin response mediator protein 2(gene name synonym)|uniprotkb:Dpysl2(gene name)|psi-mi:Dpysl2(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Foster et al. (2006)	pubmed:16396496|mint:MINT-5218203	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-921030	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2711|refseq:NP_036883.1|refseq:XP_006246658.1|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007611"(learning or memory)|go:"GO:0007614"(short-term memory)|go:"GO:0007616"(long-term memory)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010021"(amylopectin biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031550"(positive regulation of brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044381"(glucose import in response to insulin stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046323"(glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0098694"(regulation of synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0098793"(presynapse)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002441("Glucose transporter, type 4 (GLUT4)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-189200|ensembl:ENSRNOG00000017226(gene)|ensembl:ENSRNOT00000023256(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)	rgd:2517|refseq:NP_001099187.1|ensembl:ENSRNOG00000009625(gene)|ensembl:ENSRNOT00000012996(transcript)|go:"GO:0001975"(response to amphetamine)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0006897"(endocytosis)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007411"(axon guidance)|go:"GO:0007420"(brain development)|go:"GO:0008017"(microtubule binding)|go:"GO:0010975"(regulation of neuron projection development)|go:"GO:0014049"(positive regulation of glutamate secretion)|go:"GO:0016810"("hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds")|go:"GO:0019901"(protein kinase binding)|go:"GO:0021510"(spinal cord development)|go:"GO:0021772"(olfactory bulb development)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0030516"(regulation of axon extension)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042220"(response to cocaine)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043209"(myelin sheath)|go:"GO:0045664"(regulation of neuron differentiation)|go:"GO:0048489"(synaptic vesicle transport)|go:"GO:0098793"(presynapse)|interpro:IPR006680(Amidohydrolase 1)|interpro:IPR011059(Metal-dependent hydrolase, composite)|interpro:IPR011778(D-hydantoinase)|interpro:IPR030615|interpro:IPR032466|mint:P47942|reactome:R-RNO-399956|reactome:R-RNO-437239	-	-	-	caution:"The participant EBI-349571(P68370) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919386(Q7TP47) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920972(Q5XIP9) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-916419(P11980) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919578(Q8R491) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920554(Q5U3Z7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920647(Q5U2X8) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920585(Q7TP24) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-779677(P05426) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-915744(P02454) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|agonist:Insulin was shown to increase or decrease GLUT4 protein interactions in specific cases.|comment:"Insulin decreased GLUT4 interactions with the following proteins: Q9ER30 (Sarcosin), P09527 (Rab-7), O88960 (N-ethylmaleimide sensitive), P09456 (PKA I regulatory subunit), P27881 (Hexokinase type II), P07872 (Acyl-coenzyme A oxidase), Q6DGF1 (Isocitrate dehydrogenase), Q9EQX9 (Ubiquitin-conjugating), Q63446 (Polyubiquitin), P24268 (Cathepsin D), Q91XW0 (Heat shock protein 86), Q5FVH0 (unknown), P58405 (Striatin 3), Q62667 (Major vault protein), Q66H50 (unknown), Q09167 (splicing factor), Q9JHU5 (Arfaptin 1)."|comment:"Insulin increased GLUT4 interaction with the following proteins:Q9Z1P2 (R-actinin-1), P45592 (Cofilin), Q9QXQ0 (R-actinin-4), P26473 (ADP-ribosylation factor), P26437 (ADP-ribosylation factor),   Q7TNP1 (Basigin 2), Q6P6R2 (Dihydrolipoamide dehydrogenase),   P04797 (GAPDH), Q63081 (Protein disulfide isomerase), P29457 (47 kDa heat shock protein), Q9R1J8 (Leprecan), O88638 (Putative eps protein),   Q64375 (Synaptonemal complex)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:NDPK - Interactions involving proteins containing InterPro domain IPR001564, Nucleoside diphosphate kinase, core.	taxid:10116(rat-l6)|taxid:10116(Rattus norvegicus)	-	2006/02/15	2021/11/30	rogid:PbFY2lfrty8yw40Jq7ShR7xfuV410116	rogid:97yc8TNEPMcGtGNRLvl+KV+DYr010116	intact-crc:44F3A2176D02515F|rigid:9RVm0UBcqQF4k06RGKO89Bg16Q8	false	myc tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P19357	uniprotkb:P47853	intact:EBI-915426|uniprotkb:P97900|ensembl:ENSRNOP00000023256	intact:EBI-917563|ensembl:ENSRNOP00000072449	psi-mi:glut4_rat(display_long)|uniprotkb:Glucose transporter type 4, insulin-responsive(gene name synonym)|uniprotkb:Slc2a4(gene name)|psi-mi:Slc2a4(display_short)|uniprotkb:Glut4(gene name synonym)	psi-mi:pgs1_rat(display_long)|uniprotkb:Bone/cartilage proteoglycan I(gene name synonym)|uniprotkb:PG-S1(gene name synonym)|uniprotkb:Bgn(gene name)|psi-mi:Bgn(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Foster et al. (2006)	pubmed:16396496|mint:MINT-5218203	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-921030	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2711|refseq:NP_036883.1|refseq:XP_006246658.1|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007611"(learning or memory)|go:"GO:0007614"(short-term memory)|go:"GO:0007616"(long-term memory)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010021"(amylopectin biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031550"(positive regulation of brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044381"(glucose import in response to insulin stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046323"(glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0098694"(regulation of synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0098793"(presynapse)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002441("Glucose transporter, type 4 (GLUT4)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-189200|ensembl:ENSRNOG00000017226(gene)|ensembl:ENSRNOT00000023256(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)	rgd:2207|refseq:NP_058783.1|ensembl:ENSRNOG00000055962(gene)|ensembl:ENSRNOT00000085201(transcript)|go:"GO:0001974"(blood vessel remodeling)|go:"GO:0005539"(glycosaminoglycan binding)|go:"GO:0005615"(extracellular space)|go:"GO:0009986"(cell surface)|go:"GO:0019800"(peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan)|go:"GO:0030133"(transport vesicle)|go:"GO:0031012"(extracellular matrix)|go:"GO:0042383"(sarcolemma)|go:"GO:0050840"(extracellular matrix binding)|go:"GO:0060348"(bone development)|go:"GO:0061975"(articular cartilage development)|interpro:IPR000372(Leucine-rich repeat, cysteine-rich flanking region, N-terminal)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR016352(Small leucine-rich proteoglycan, class I, decorin/asporin/byglycan)|interpro:IPR028547|interpro:IPR032675|reactome:R-RNO-1971475|reactome:R-RNO-2022870|reactome:R-RNO-2022923|reactome:R-RNO-2024101|reactome:R-RNO-3000178	-	-	-	caution:"The participant EBI-349571(P68370) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919386(Q7TP47) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920972(Q5XIP9) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-916419(P11980) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919578(Q8R491) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920554(Q5U3Z7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920647(Q5U2X8) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920585(Q7TP24) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-779677(P05426) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-915744(P02454) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|agonist:Insulin was shown to increase or decrease GLUT4 protein interactions in specific cases.|comment:"Insulin decreased GLUT4 interactions with the following proteins: Q9ER30 (Sarcosin), P09527 (Rab-7), O88960 (N-ethylmaleimide sensitive), P09456 (PKA I regulatory subunit), P27881 (Hexokinase type II), P07872 (Acyl-coenzyme A oxidase), Q6DGF1 (Isocitrate dehydrogenase), Q9EQX9 (Ubiquitin-conjugating), Q63446 (Polyubiquitin), P24268 (Cathepsin D), Q91XW0 (Heat shock protein 86), Q5FVH0 (unknown), P58405 (Striatin 3), Q62667 (Major vault protein), Q66H50 (unknown), Q09167 (splicing factor), Q9JHU5 (Arfaptin 1)."|comment:"Insulin increased GLUT4 interaction with the following proteins:Q9Z1P2 (R-actinin-1), P45592 (Cofilin), Q9QXQ0 (R-actinin-4), P26473 (ADP-ribosylation factor), P26437 (ADP-ribosylation factor),   Q7TNP1 (Basigin 2), Q6P6R2 (Dihydrolipoamide dehydrogenase),   P04797 (GAPDH), Q63081 (Protein disulfide isomerase), P29457 (47 kDa heat shock protein), Q9R1J8 (Leprecan), O88638 (Putative eps protein),   Q64375 (Synaptonemal complex)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:NDPK - Interactions involving proteins containing InterPro domain IPR001564, Nucleoside diphosphate kinase, core.	taxid:10116(rat-l6)|taxid:10116(Rattus norvegicus)	-	2006/02/15	2021/11/30	rogid:PbFY2lfrty8yw40Jq7ShR7xfuV410116	rogid:y5uL0GPot1EHpM1UIKRfmWJXdEI10116	intact-crc:44F3A2176D02515F|rigid:9RVm0UBcqQF4k06RGKO89Bg16Q8	false	myc tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P19357	uniprotkb:P46462	intact:EBI-915426|uniprotkb:P97900|ensembl:ENSRNOP00000023256	intact:EBI-399011|ensembl:ENSRNOP00000040121	psi-mi:glut4_rat(display_long)|uniprotkb:Glucose transporter type 4, insulin-responsive(gene name synonym)|uniprotkb:Slc2a4(gene name)|psi-mi:Slc2a4(display_short)|uniprotkb:Glut4(gene name synonym)	psi-mi:tera_rat(display_long)|uniprotkb:Vcp(gene name)|psi-mi:Vcp(display_short)|uniprotkb:"15S Mg(2+)-ATPase p97 subunit"(gene name synonym)|uniprotkb:Valosin-containing protein(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Foster et al. (2006)	pubmed:16396496|mint:MINT-5218203	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-921030	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2711|refseq:NP_036883.1|refseq:XP_006246658.1|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007611"(learning or memory)|go:"GO:0007614"(short-term memory)|go:"GO:0007616"(long-term memory)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010021"(amylopectin biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031550"(positive regulation of brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044381"(glucose import in response to insulin stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046323"(glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0098694"(regulation of synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0098793"(presynapse)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002441("Glucose transporter, type 4 (GLUT4)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-189200|ensembl:ENSRNOG00000017226(gene)|ensembl:ENSRNOT00000023256(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)	rgd:621595|refseq:NP_446316.1|go:"GO:0006914"(autophagy)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0008289"(lipid binding)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0010498"(proteasomal protein catabolic process)|go:"GO:0010918"(positive regulation of mitochondrial membrane potential)|go:"GO:0016236"(macroautophagy)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019079"(viral genome replication)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0019985"(translesion synthesis)|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0030970"(retrograde protein transport, ER to cytosol)|go:"GO:0031334"(positive regulation of protein-containing complex assembly)|ensembl:ENSRNOG00000034242(gene)|ensembl:ENSRNOT00000046102(transcript)|go:"GO:0000502"(proteasome complex)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005811"(lipid droplet)|go:"GO:0005829"(cytosol)|go:"GO:0006281"(DNA repair)|go:"GO:0006302"(double-strand break repair)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006734"(NADH metabolic process)|go:"GO:0006888"(endoplasmic reticulum to Golgi vesicle-mediated transport)|go:"GO:0031593"(polyubiquitin modification-dependent protein binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0032510"(endosome to lysosome transport via multivesicular body sorting pathway)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034098"(VCP-NPL4-UFD1 AAA ATPase complex)|go:"GO:0034605"(cellular response to heat)|go:"GO:0035617"(stress granule disassembly)|go:"GO:0035800"(deubiquitinase activator activity)|go:"GO:0035861"(site of double-strand break)|go:"GO:0036297"(interstrand cross-link repair)|go:"GO:0036435"(K48-linked polyubiquitin modification-dependent protein binding)|go:"GO:0036503"(ERAD pathway)|go:"GO:0036513"(Derlin-1 retrotranslocation complex)|go:"GO:0042288"(MHC class I protein binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|reactome:R-RNO-9013407|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043531"(ADP binding)|go:"GO:0044389"(ubiquitin-like protein ligase binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0045879"(negative regulation of smoothened signaling pathway)|go:"GO:0046034"(ATP metabolic process)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050807"(regulation of synapse organization)|go:"GO:0051228"(mitotic spindle disassembly)|go:"GO:0061857"(endoplasmic reticulum stress-induced pre-emptive quality control)|go:"GO:0070842"(aggresome assembly)|go:"GO:0071712"(ER-associated misfolded protein catabolic process)|go:"GO:0072389"(flavin adenine dinucleotide catabolic process)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0097352"(autophagosome maturation)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0106300"(protein-DNA covalent cross-linking repair)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1903006"(positive regulation of protein K63-linked deubiquitination)|go:"GO:1903007"(positive regulation of Lys63-specific deubiquitinase activity)|go:"GO:1903715"(regulation of aerobic respiration)|go:"GO:1903843"(cellular response to arsenite ion)|go:"GO:1903862"(positive regulation of oxidative phosphorylation)|go:"GO:1904288"(BAT3 complex binding)|go:"GO:1904949"(ATPase complex)|go:"GO:1905634"(regulation of protein localization to chromatin)|go:"GO:1990381"(ubiquitin-specific protease binding)|go:"GO:1990730"(VCP-NSFL1C complex)|go:"GO:2000060"(positive regulation of ubiquitin-dependent protein catabolic process)|go:"GO:2001171"(positive regulation of ATP biosynthetic process)|interpro:IPR003338(AAA ATPase VAT, N-terminal)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR003959(AAA ATPase, core)|interpro:IPR003960(AAA ATPase, conserved site)|interpro:IPR004201(Cell division protein 48, CDC48, domain 2)|interpro:IPR005938(AAA ATPase, CDC48)|interpro:IPR009010(Aspartate decarboxylase-like fold)|interpro:IPR015415(Vps4 oligomerisation, C-terminal)|interpro:IPR027417|interpro:IPR029067|interpro:IPR041569|mint:P46462|reactome:R-RNO-110320|reactome:R-RNO-3371511|reactome:R-RNO-382556|reactome:R-RNO-532668|reactome:R-RNO-5358346|reactome:R-RNO-5689877|reactome:R-RNO-5689896|reactome:R-RNO-6798695	-	-	-	caution:"The participant EBI-349571(P68370) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919386(Q7TP47) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920972(Q5XIP9) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-916419(P11980) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919578(Q8R491) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920554(Q5U3Z7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920647(Q5U2X8) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920585(Q7TP24) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-779677(P05426) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-915744(P02454) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|agonist:Insulin was shown to increase or decrease GLUT4 protein interactions in specific cases.|comment:"Insulin decreased GLUT4 interactions with the following proteins: Q9ER30 (Sarcosin), P09527 (Rab-7), O88960 (N-ethylmaleimide sensitive), P09456 (PKA I regulatory subunit), P27881 (Hexokinase type II), P07872 (Acyl-coenzyme A oxidase), Q6DGF1 (Isocitrate dehydrogenase), Q9EQX9 (Ubiquitin-conjugating), Q63446 (Polyubiquitin), P24268 (Cathepsin D), Q91XW0 (Heat shock protein 86), Q5FVH0 (unknown), P58405 (Striatin 3), Q62667 (Major vault protein), Q66H50 (unknown), Q09167 (splicing factor), Q9JHU5 (Arfaptin 1)."|comment:"Insulin increased GLUT4 interaction with the following proteins:Q9Z1P2 (R-actinin-1), P45592 (Cofilin), Q9QXQ0 (R-actinin-4), P26473 (ADP-ribosylation factor), P26437 (ADP-ribosylation factor),   Q7TNP1 (Basigin 2), Q6P6R2 (Dihydrolipoamide dehydrogenase),   P04797 (GAPDH), Q63081 (Protein disulfide isomerase), P29457 (47 kDa heat shock protein), Q9R1J8 (Leprecan), O88638 (Putative eps protein),   Q64375 (Synaptonemal complex)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:NDPK - Interactions involving proteins containing InterPro domain IPR001564, Nucleoside diphosphate kinase, core.	taxid:10116(rat-l6)|taxid:10116(Rattus norvegicus)	-	2006/02/15	2021/11/30	rogid:PbFY2lfrty8yw40Jq7ShR7xfuV410116	rogid:U39+QQfgVQlS+3gjtwc3IDz0VME10116	intact-crc:44F3A2176D02515F|rigid:9RVm0UBcqQF4k06RGKO89Bg16Q8	false	myc tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P19357	uniprotkb:P45592	intact:EBI-915426|uniprotkb:P97900|ensembl:ENSRNOP00000023256	intact:EBI-917556|ensembl:ENSRNOP00000059624	psi-mi:glut4_rat(display_long)|uniprotkb:Glucose transporter type 4, insulin-responsive(gene name synonym)|uniprotkb:Slc2a4(gene name)|psi-mi:Slc2a4(display_short)|uniprotkb:Glut4(gene name synonym)	psi-mi:cof1_rat(display_long)|uniprotkb:Cofilin, non-muscle isoform(gene name synonym)|uniprotkb:Cfl1(gene name)|psi-mi:Cfl1(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Foster et al. (2006)	pubmed:16396496|mint:MINT-5218203	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-921030	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2711|refseq:NP_036883.1|refseq:XP_006246658.1|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007611"(learning or memory)|go:"GO:0007614"(short-term memory)|go:"GO:0007616"(long-term memory)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010021"(amylopectin biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031550"(positive regulation of brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044381"(glucose import in response to insulin stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046323"(glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0098694"(regulation of synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0098793"(presynapse)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002441("Glucose transporter, type 4 (GLUT4)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-189200|ensembl:ENSRNOG00000017226(gene)|ensembl:ENSRNOT00000023256(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)	rgd:69285|refseq:NP_058843.1|ensembl:ENSRNOG00000020660(gene)|ensembl:ENSRNOT00000015962(transcript)|go:"GO:0000281"(mitotic cytokinesis)|go:"GO:0001755"(neural crest cell migration)|go:"GO:0001842"(neural fold formation)|go:"GO:0003779"(actin binding)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005925"(focal adhesion)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007015"(actin filament organization)|go:"GO:0007162"(negative regulation of cell adhesion)|go:"GO:0009615"(response to virus)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010593"(negative regulation of lamellipodium assembly)|go:"GO:0014070"(response to organic cyclic compound)|go:"GO:0014823"(response to activity)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016363"(nuclear matrix)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0021766"(hippocampus development)|go:"GO:0022604"(regulation of cell morphogenesis)|go:"GO:0030010"(establishment of cell polarity)|go:"GO:0030027"(lamellipodium)|go:"GO:0030030"(cell projection organization)|go:"GO:0030042"(actin filament depolymerization)|go:"GO:0030043"(actin filament fragmentation)|go:"GO:0030175"(filopodium)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0030426"(growth cone)|go:"GO:0030835"(negative regulation of actin filament depolymerization)|go:"GO:0030836"(positive regulation of actin filament depolymerization)|go:"GO:0030864"(cortical actin cytoskeleton)|go:"GO:0031252"(cell leading edge)|go:"GO:0031258"(lamellipodium membrane)|go:"GO:0031915"(positive regulation of synaptic plasticity)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0032232"(negative regulation of actin filament bundle assembly)|go:"GO:0032587"(ruffle membrane)|go:"GO:0040019"(positive regulation of embryonic development)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043197"(dendritic spine)|go:"GO:0043200"(response to amino acid)|go:"GO:0044794"(positive regulation by host of viral process)|go:"GO:0045792"(negative regulation of cell size)|go:"GO:0045862"(positive regulation of proteolysis)|go:"GO:0048870"(cell motility)|go:"GO:0051014"(actin filament severing)|go:"GO:0051015"(actin filament binding)|go:"GO:0051293"(establishment of spindle localization)|go:"GO:0051511"(negative regulation of unidimensional cell growth)|go:"GO:0051894"(positive regulation of focal adhesion assembly)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0061001"(regulation of dendritic spine morphogenesis)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071354"(cellular response to interleukin-6)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071362"(cellular response to ether)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|go:"GO:0090732"(cofilin-actin rod)|go:"GO:0097060"(synaptic membrane)|go:"GO:0098885"(modification of postsynaptic actin cytoskeleton)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1902936"(phosphatidylinositol bisphosphate binding)|go:"GO:1902951"(negative regulation of dendritic spine maintenance)|go:"GO:1904783"(positive regulation of NMDA glutamate receptor activity)|go:"GO:1905873"(positive regulation of protein localization to cell leading edge)|go:"GO:1905875"(negative regulation of postsynaptic density organization)|go:"GO:1990314"(cellular response to insulin-like growth factor stimulus)|go:"GO:2000146"(negative regulation of cell motility)|go:"GO:2000147"(positive regulation of cell motility)|go:"GO:2000784"(positive regulation of establishment of cell polarity regulating cell shape)|go:"GO:2000814"(positive regulation of barbed-end actin filament capping)|interpro:IPR002108(Actin-binding, cofilin/tropomyosin type)|interpro:IPR017904|interpro:IPR027234|interpro:IPR029006|mint:P45592	-	-	-	caution:"The participant EBI-349571(P68370) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919386(Q7TP47) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920972(Q5XIP9) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-916419(P11980) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919578(Q8R491) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920554(Q5U3Z7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920647(Q5U2X8) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920585(Q7TP24) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-779677(P05426) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-915744(P02454) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|agonist:Insulin was shown to increase or decrease GLUT4 protein interactions in specific cases.|comment:"Insulin decreased GLUT4 interactions with the following proteins: Q9ER30 (Sarcosin), P09527 (Rab-7), O88960 (N-ethylmaleimide sensitive), P09456 (PKA I regulatory subunit), P27881 (Hexokinase type II), P07872 (Acyl-coenzyme A oxidase), Q6DGF1 (Isocitrate dehydrogenase), Q9EQX9 (Ubiquitin-conjugating), Q63446 (Polyubiquitin), P24268 (Cathepsin D), Q91XW0 (Heat shock protein 86), Q5FVH0 (unknown), P58405 (Striatin 3), Q62667 (Major vault protein), Q66H50 (unknown), Q09167 (splicing factor), Q9JHU5 (Arfaptin 1)."|comment:"Insulin increased GLUT4 interaction with the following proteins:Q9Z1P2 (R-actinin-1), P45592 (Cofilin), Q9QXQ0 (R-actinin-4), P26473 (ADP-ribosylation factor), P26437 (ADP-ribosylation factor),   Q7TNP1 (Basigin 2), Q6P6R2 (Dihydrolipoamide dehydrogenase),   P04797 (GAPDH), Q63081 (Protein disulfide isomerase), P29457 (47 kDa heat shock protein), Q9R1J8 (Leprecan), O88638 (Putative eps protein),   Q64375 (Synaptonemal complex)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:NDPK - Interactions involving proteins containing InterPro domain IPR001564, Nucleoside diphosphate kinase, core.	taxid:10116(rat-l6)|taxid:10116(Rattus norvegicus)	-	2006/02/15	2021/11/30	rogid:PbFY2lfrty8yw40Jq7ShR7xfuV410116	rogid:xwFEqVHm0stGEHpMoijBFH/LwPY10116	intact-crc:44F3A2176D02515F|rigid:9RVm0UBcqQF4k06RGKO89Bg16Q8	false	myc tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P19357	uniprotkb:P45479	intact:EBI-915426|uniprotkb:P97900|ensembl:ENSRNOP00000023256	intact:EBI-917548|uniprotkb:A0JN20|ensembl:ENSRNOP00000017998	psi-mi:glut4_rat(display_long)|uniprotkb:Glucose transporter type 4, insulin-responsive(gene name synonym)|uniprotkb:Slc2a4(gene name)|psi-mi:Slc2a4(display_short)|uniprotkb:Glut4(gene name synonym)	psi-mi:ppt1_rat(display_long)|uniprotkb:Palmitoyl-protein hydrolase 1(gene name synonym)|uniprotkb:Ppt1(gene name)|psi-mi:Ppt1(display_short)|uniprotkb:Ppt(gene name synonym)|uniprotkb:Cln1(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Foster et al. (2006)	pubmed:16396496|mint:MINT-5218203	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-921030	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2711|refseq:NP_036883.1|refseq:XP_006246658.1|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007611"(learning or memory)|go:"GO:0007614"(short-term memory)|go:"GO:0007616"(long-term memory)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010021"(amylopectin biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031550"(positive regulation of brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044381"(glucose import in response to insulin stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046323"(glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0098694"(regulation of synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0098793"(presynapse)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002441("Glucose transporter, type 4 (GLUT4)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-189200|ensembl:ENSRNOG00000017226(gene)|ensembl:ENSRNOT00000023256(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)	rgd:61994|refseq:NP_071947.1|go:"GO:0045202"(synapse)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0048260"(positive regulation of receptor-mediated endocytosis)|go:"GO:0048549"(positive regulation of pinocytosis)|go:"GO:0120146"(sulfatide binding)|interpro:IPR002472(Palmitoyl protein thioesterase)|interpro:IPR029058|interpro:IPR030294|reactome:R-RNO-75105|ensembl:ENSRNOG00000012616(gene)|ensembl:ENSRNOT00000017998(transcript)|go:"GO:0002084"(protein depalmitoylation)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005764"(lysosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0006907"(pinocytosis)|go:"GO:0007040"(lysosome organization)|go:"GO:0007042"(lysosomal lumen acidification)|go:"GO:0007269"(neurotransmitter secretion)|go:"GO:0007399"(nervous system development)|go:"GO:0007420"(brain development)|go:"GO:0007601"(visual perception)|go:"GO:0007625"(grooming behavior)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008306"(associative learning)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0008474"("palmitoyl-(protein) hydrolase activity")|go:"GO:0015031"(protein transport)|go:"GO:0016042"(lipid catabolic process)|go:"GO:0016290"(palmitoyl-CoA hydrolase activity)|go:"GO:0016790"(thiolester hydrolase activity)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0031579"(membrane raft organization)|go:"GO:0032429"(regulation of phospholipase A2 activity)|go:"GO:0035727"(lysophosphatidic acid binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0044257"(cellular protein catabolic process)|go:"GO:0044265"(cellular macromolecule catabolic process)|go:"GO:0045121"(membrane raft)	-	-	-	caution:"The participant EBI-349571(P68370) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919386(Q7TP47) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920972(Q5XIP9) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-916419(P11980) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919578(Q8R491) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920554(Q5U3Z7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920647(Q5U2X8) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920585(Q7TP24) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-779677(P05426) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-915744(P02454) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|agonist:Insulin was shown to increase or decrease GLUT4 protein interactions in specific cases.|comment:"Insulin decreased GLUT4 interactions with the following proteins: Q9ER30 (Sarcosin), P09527 (Rab-7), O88960 (N-ethylmaleimide sensitive), P09456 (PKA I regulatory subunit), P27881 (Hexokinase type II), P07872 (Acyl-coenzyme A oxidase), Q6DGF1 (Isocitrate dehydrogenase), Q9EQX9 (Ubiquitin-conjugating), Q63446 (Polyubiquitin), P24268 (Cathepsin D), Q91XW0 (Heat shock protein 86), Q5FVH0 (unknown), P58405 (Striatin 3), Q62667 (Major vault protein), Q66H50 (unknown), Q09167 (splicing factor), Q9JHU5 (Arfaptin 1)."|comment:"Insulin increased GLUT4 interaction with the following proteins:Q9Z1P2 (R-actinin-1), P45592 (Cofilin), Q9QXQ0 (R-actinin-4), P26473 (ADP-ribosylation factor), P26437 (ADP-ribosylation factor),   Q7TNP1 (Basigin 2), Q6P6R2 (Dihydrolipoamide dehydrogenase),   P04797 (GAPDH), Q63081 (Protein disulfide isomerase), P29457 (47 kDa heat shock protein), Q9R1J8 (Leprecan), O88638 (Putative eps protein),   Q64375 (Synaptonemal complex)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:NDPK - Interactions involving proteins containing InterPro domain IPR001564, Nucleoside diphosphate kinase, core.	taxid:10116(rat-l6)|taxid:10116(Rattus norvegicus)	-	2006/02/15	2021/11/30	rogid:PbFY2lfrty8yw40Jq7ShR7xfuV410116	rogid:VAa8Me/juulp0tRvbgcitdIpp8Y10116	intact-crc:44F3A2176D02515F|rigid:9RVm0UBcqQF4k06RGKO89Bg16Q8	false	myc tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P19357	uniprotkb:P63004	intact:EBI-915426|uniprotkb:P97900|ensembl:ENSRNOP00000023256	intact:EBI-917535|uniprotkb:O35592|uniprotkb:P43035|uniprotkb:P81692|uniprotkb:Q9R2A6|ensembl:ENSRNOP00000003696|ensembl:ENSRNOP00000075779	psi-mi:glut4_rat(display_long)|uniprotkb:Glucose transporter type 4, insulin-responsive(gene name synonym)|uniprotkb:Slc2a4(gene name)|psi-mi:Slc2a4(display_short)|uniprotkb:Glut4(gene name synonym)	psi-mi:lis1_rat(display_long)|uniprotkb:PAF acetylhydrolase 45 kDa subunit(gene name synonym)|uniprotkb:PAF-AH alpha(gene name synonym)|uniprotkb:Lissencephaly-1 protein(gene name synonym)|uniprotkb:Pafah1b1(gene name)|psi-mi:Pafah1b1(display_short)|uniprotkb:Lis1(gene name synonym)|uniprotkb:Lis-1(gene name synonym)|uniprotkb:Pafaha(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Foster et al. (2006)	pubmed:16396496|mint:MINT-5218203	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-921030	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2711|refseq:NP_036883.1|refseq:XP_006246658.1|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007611"(learning or memory)|go:"GO:0007614"(short-term memory)|go:"GO:0007616"(long-term memory)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010021"(amylopectin biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031550"(positive regulation of brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044381"(glucose import in response to insulin stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046323"(glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0098694"(regulation of synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0098793"(presynapse)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002441("Glucose transporter, type 4 (GLUT4)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-189200|ensembl:ENSRNOG00000017226(gene)|ensembl:ENSRNOT00000023256(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)	rgd:620331|refseq:NP_113951.1|refseq:XP_017453039.1|ensembl:ENSRNOG00000002755(gene)|ensembl:ENSRNOT00000003696(transcript)|ensembl:ENSRNOT00000092712(transcript)|go:"GO:0000132"(establishment of mitotic spindle orientation)|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0000235"(astral microtubule)|go:"GO:0000776"(kinetochore)|go:"GO:0001667"(ameboidal-type cell migration)|go:"GO:0001675"(acrosome assembly)|go:"GO:0001764"(neuron migration)|go:"GO:0001961"(positive regulation of cytokine-mediated signaling pathway)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005871"(kinesin complex)|go:"GO:0005875"(microtubule associated complex)|go:"GO:0005881"(cytoplasmic microtubule)|go:"GO:0005938"(cell cortex)|go:"GO:0007017"(microtubule-based process)|go:"GO:0007097"(nuclear migration)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007281"(germ cell development)|go:"GO:0007405"(neuroblast proliferation)|go:"GO:0007420"(brain development)|go:"GO:0007611"(learning or memory)|go:"GO:0008017"(microtubule binding)|go:"GO:0008090"(retrograde axonal transport)|go:"GO:0008247"(1-alkyl-2-acetylglycerophosphocholine esterase complex)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0009306"(protein secretion)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016042"(lipid catabolic process)|go:"GO:0016477"(cell migration)|go:"GO:0017145"(stem cell division)|go:"GO:0019226"(transmission of nerve impulse)|go:"GO:0021540"(corpus callosum morphogenesis)|go:"GO:0021766"(hippocampus development)|go:"GO:0021819"(layer formation in cerebral cortex)|go:"GO:0021895"(cerebral cortex neuron differentiation)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030424"(axon)|go:"GO:0030426"(growth cone)|go:"GO:0031023"(microtubule organizing center organization)|go:"GO:0031252"(cell leading edge)|go:"GO:0031514"(motile cilium)|go:"GO:0031965"(nuclear membrane)|go:"GO:0031982"(vesicle)|go:"GO:0032420"(stereocilium)|go:"GO:0036035"(osteoclast development)|go:"GO:0038026"(reelin-mediated signaling pathway)|go:"GO:0040019"(positive regulation of embryonic development)|go:"GO:0042249"(establishment of planar polarity of embryonic epithelium)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0043622"(cortical microtubule organization)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045505"(dynein intermediate chain binding)|go:"GO:0045773"(positive regulation of axon extension)|go:"GO:0045931"(positive regulation of mitotic cell cycle)|go:"GO:0046329"(negative regulation of JNK cascade)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0047179"(platelet-activating factor acetyltransferase activity)|go:"GO:0047496"(vesicle transport along microtubule)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0051010"(microtubule plus-end binding)|go:"GO:0051012"(microtubule sliding)|go:"GO:0051081"(nuclear membrane disassembly)|go:"GO:0051130"(positive regulation of cellular component organization)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0051660"(establishment of centrosome localization)|go:"GO:0051661"(maintenance of centrosome location)|go:"GO:0060117"(auditory receptor cell development)|go:"GO:0061003"(positive regulation of dendritic spine morphogenesis)|go:"GO:0070507"(regulation of microtubule cytoskeleton organization)|go:"GO:0070840"(dynein complex binding)|go:"GO:0090102"(cochlea development)|go:"GO:0090176"(microtubule cytoskeleton organization involved in establishment of planar polarity)|go:"GO:0090724"(central region of growth cone)|go:"GO:1904115"(axon cytoplasm)|go:"GO:2000574"(obsolete regulation of microtubule motor activity)|interpro:IPR001680(WD40 repeat)|interpro:IPR006594(LisH dimerisation motif)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR017252(Dynein regulator)|interpro:IPR019775|interpro:IPR020472|interpro:IPR036322|interpro:IPR037190|reactome:R-RNO-141444|reactome:R-RNO-2467813|reactome:R-RNO-2500257|reactome:R-RNO-2565942|reactome:R-RNO-380259|reactome:R-RNO-380270|reactome:R-RNO-380284|reactome:R-RNO-380320|reactome:R-RNO-5620912|reactome:R-RNO-5663220|reactome:R-RNO-6811436|reactome:R-RNO-68877|reactome:R-RNO-8854518|reactome:R-RNO-9648025	-	-	-	caution:"The participant EBI-349571(P68370) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919386(Q7TP47) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920972(Q5XIP9) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-916419(P11980) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919578(Q8R491) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920554(Q5U3Z7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920647(Q5U2X8) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920585(Q7TP24) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-779677(P05426) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-915744(P02454) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|agonist:Insulin was shown to increase or decrease GLUT4 protein interactions in specific cases.|comment:"Insulin decreased GLUT4 interactions with the following proteins: Q9ER30 (Sarcosin), P09527 (Rab-7), O88960 (N-ethylmaleimide sensitive), P09456 (PKA I regulatory subunit), P27881 (Hexokinase type II), P07872 (Acyl-coenzyme A oxidase), Q6DGF1 (Isocitrate dehydrogenase), Q9EQX9 (Ubiquitin-conjugating), Q63446 (Polyubiquitin), P24268 (Cathepsin D), Q91XW0 (Heat shock protein 86), Q5FVH0 (unknown), P58405 (Striatin 3), Q62667 (Major vault protein), Q66H50 (unknown), Q09167 (splicing factor), Q9JHU5 (Arfaptin 1)."|comment:"Insulin increased GLUT4 interaction with the following proteins:Q9Z1P2 (R-actinin-1), P45592 (Cofilin), Q9QXQ0 (R-actinin-4), P26473 (ADP-ribosylation factor), P26437 (ADP-ribosylation factor),   Q7TNP1 (Basigin 2), Q6P6R2 (Dihydrolipoamide dehydrogenase),   P04797 (GAPDH), Q63081 (Protein disulfide isomerase), P29457 (47 kDa heat shock protein), Q9R1J8 (Leprecan), O88638 (Putative eps protein),   Q64375 (Synaptonemal complex)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:NDPK - Interactions involving proteins containing InterPro domain IPR001564, Nucleoside diphosphate kinase, core.	taxid:10116(rat-l6)|taxid:10116(Rattus norvegicus)	-	2006/02/15	2021/11/30	rogid:PbFY2lfrty8yw40Jq7ShR7xfuV410116	rogid:worzim1DpTldfv3SQdodqPmMozk10116	intact-crc:44F3A2176D02515F|rigid:9RVm0UBcqQF4k06RGKO89Bg16Q8	false	myc tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P19357	uniprotkb:P42930	intact:EBI-915426|uniprotkb:P97900|ensembl:ENSRNOP00000023256	intact:EBI-917489|uniprotkb:Q63922|uniprotkb:Q9QWA8	psi-mi:glut4_rat(display_long)|uniprotkb:Glucose transporter type 4, insulin-responsive(gene name synonym)|uniprotkb:Slc2a4(gene name)|psi-mi:Slc2a4(display_short)|uniprotkb:Glut4(gene name synonym)	psi-mi:hspb1_rat(display_long)|uniprotkb:Heat shock 27 kDa protein(gene name synonym)|uniprotkb:Hspb1(gene name)|psi-mi:Hspb1(display_short)|uniprotkb:Hsp27(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Foster et al. (2006)	pubmed:16396496|mint:MINT-5218203	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-921030	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2711|refseq:NP_036883.1|refseq:XP_006246658.1|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007611"(learning or memory)|go:"GO:0007614"(short-term memory)|go:"GO:0007616"(long-term memory)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010021"(amylopectin biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031550"(positive regulation of brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044381"(glucose import in response to insulin stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046323"(glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0098694"(regulation of synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0098793"(presynapse)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002441("Glucose transporter, type 4 (GLUT4)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-189200|ensembl:ENSRNOG00000017226(gene)|ensembl:ENSRNOT00000023256(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)	rgd:61306|interpro:IPR001436(Alpha crystallin/Heat shock protein)|interpro:IPR002068(Heat shock protein Hsp20)|interpro:IPR008978(HSP20-like chaperone)|interpro:IPR037876|mint:P42930|go:"GO:0000502"(proteasome complex)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0002931"(response to ischemia)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005819"(spindle)|go:"GO:0005886"(plasma membrane)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0007565"(female pregnancy)|go:"GO:0007568"(aging)|go:"GO:0008426"(protein kinase C inhibitor activity)|go:"GO:0009615"(response to virus)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030018"(Z disc)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0031430"(M band)|go:"GO:0031674"(I band)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|go:"GO:0035994"(response to muscle stretch)|go:"GO:0038033"(positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0043204"(perikaryon)|go:"GO:0043292"(contractile fiber)|go:"GO:0043536"(positive regulation of blood vessel endothelial cell migration)|go:"GO:0044183"(protein folding chaperone)|go:"GO:0045202"(synapse)|go:"GO:0045590"(negative regulation of regulatory T cell differentiation)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0061077"(chaperone-mediated protein folding)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0071348"(cellular response to interleukin-11)|go:"GO:0097512"(cardiac myofibril)|go:"GO:0098839"(postsynaptic density membrane)|go:"GO:0099641"(anterograde axonal protein transport)|go:"GO:1902176"(negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway)|go:"GO:1903202"(negative regulation of oxidative stress-induced cell death)|go:"GO:1903545"(cellular response to butyrate)|go:"GO:1904115"(axon cytoplasm)|go:"GO:1990776"(response to angiotensin)|go:"GO:2001028"(positive regulation of endothelial cell chemotaxis)|go:"GO:2001234"(negative regulation of apoptotic signaling pathway)|reactome:R-RNO-4420097|reactome:R-RNO-450408|reactome:R-RNO-5687128|reactome:R-RNO-9009391	-	-	-	caution:"The participant EBI-349571(P68370) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919386(Q7TP47) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920972(Q5XIP9) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-916419(P11980) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919578(Q8R491) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920554(Q5U3Z7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920647(Q5U2X8) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920585(Q7TP24) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-779677(P05426) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-915744(P02454) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|agonist:Insulin was shown to increase or decrease GLUT4 protein interactions in specific cases.|comment:"Insulin decreased GLUT4 interactions with the following proteins: Q9ER30 (Sarcosin), P09527 (Rab-7), O88960 (N-ethylmaleimide sensitive), P09456 (PKA I regulatory subunit), P27881 (Hexokinase type II), P07872 (Acyl-coenzyme A oxidase), Q6DGF1 (Isocitrate dehydrogenase), Q9EQX9 (Ubiquitin-conjugating), Q63446 (Polyubiquitin), P24268 (Cathepsin D), Q91XW0 (Heat shock protein 86), Q5FVH0 (unknown), P58405 (Striatin 3), Q62667 (Major vault protein), Q66H50 (unknown), Q09167 (splicing factor), Q9JHU5 (Arfaptin 1)."|comment:"Insulin increased GLUT4 interaction with the following proteins:Q9Z1P2 (R-actinin-1), P45592 (Cofilin), Q9QXQ0 (R-actinin-4), P26473 (ADP-ribosylation factor), P26437 (ADP-ribosylation factor),   Q7TNP1 (Basigin 2), Q6P6R2 (Dihydrolipoamide dehydrogenase),   P04797 (GAPDH), Q63081 (Protein disulfide isomerase), P29457 (47 kDa heat shock protein), Q9R1J8 (Leprecan), O88638 (Putative eps protein),   Q64375 (Synaptonemal complex)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:NDPK - Interactions involving proteins containing InterPro domain IPR001564, Nucleoside diphosphate kinase, core.	taxid:10116(rat-l6)|taxid:10116(Rattus norvegicus)	-	2006/02/15	2021/11/30	rogid:PbFY2lfrty8yw40Jq7ShR7xfuV410116	rogid:4VkGr8nFFRoQa+1RiEto9b3gIv410116	intact-crc:44F3A2176D02515F|rigid:9RVm0UBcqQF4k06RGKO89Bg16Q8	false	myc tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P19357	uniprotkb:Q6MGB8	intact:EBI-915426|uniprotkb:P97900|ensembl:ENSRNOP00000023256	intact:EBI-918895|uniprotkb:F7ERG5|ensembl:ENSRNOP00000050701	psi-mi:glut4_rat(display_long)|uniprotkb:Glucose transporter type 4, insulin-responsive(gene name synonym)|uniprotkb:Slc2a4(gene name)|psi-mi:Slc2a4(display_short)|uniprotkb:Glut4(gene name synonym)	psi-mi:q6mgb8_rat(display_long)|uniprotkb:RT1-A2(gene name)|psi-mi:RT1-A2(display_short)|uniprotkb:AA926063(gene name synonym)|uniprotkb:B3galt4(gene name synonym)|uniprotkb:Cdk2ap1-ps1(gene name synonym)|uniprotkb:Col11a2(gene name synonym)|uniprotkb:RT1-A1(gene name synonym)|uniprotkb:Hsd17b8(gene name synonym)|uniprotkb:Kifc1(gene name synonym)|uniprotkb:LOC224733l-1(gene name synonym)|uniprotkb:LOC224733l-2(gene name synonym)|uniprotkb:Phf1(gene name synonym)|uniprotkb:Daxx(gene name synonym)|uniprotkb:RT1-A3(gene name synonym)|uniprotkb:RT1-DOa(gene name synonym)|uniprotkb:RT1-Hb(gene name synonym)|uniprotkb:RT1-Ke4(gene name synonym)|uniprotkb:Rps25-ps1(gene name synonym)|uniprotkb:Rxrb(gene name synonym)|uniprotkb:Sacm2l-ps1(gene name synonym)|uniprotkb:Sacm2l-ps2(gene name synonym)|uniprotkb:Sec61-ps(gene name synonym)|uniprotkb:Syngap1(gene name synonym)|uniprotkb:RT1-A2n(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Foster et al. (2006)	pubmed:16396496|mint:MINT-5218203	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-921030	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2711|refseq:NP_036883.1|refseq:XP_006246658.1|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007611"(learning or memory)|go:"GO:0007614"(short-term memory)|go:"GO:0007616"(long-term memory)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010021"(amylopectin biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031550"(positive regulation of brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044381"(glucose import in response to insulin stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046323"(glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0098694"(regulation of synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0098793"(presynapse)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002441("Glucose transporter, type 4 (GLUT4)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-189200|ensembl:ENSRNOG00000017226(gene)|ensembl:ENSRNOT00000023256(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)	refseq:NP_001008829.1|rgd:1595923|ensembl:ENSRNOG00000030712(gene)|ensembl:ENSRNOT00000052270(transcript)|go:"GO:0001916"(positive regulation of T cell mediated cytotoxicity)|go:"GO:0002476"(antigen processing and presentation of endogenous peptide antigen via MHC class Ib)|go:"GO:0002485"(antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-dependent)|go:"GO:0005615"(extracellular space)|go:"GO:0005886"(plasma membrane)|go:"GO:0006955"(immune response)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0016021"(integral component of membrane)|interpro:IPR001039(MHC class I, alpha chain, alpha1 and alpha2)|interpro:IPR003006(Immunoglobulin/major histocompatibility complex, conserved site)|interpro:IPR003597(Immunoglobulin C1-set)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR010579(MHC class I, alpha chain, C-terminal)|interpro:IPR011161(MHC class I-like antigen recognition)|interpro:IPR011162(MHC classes I and II-like antigen recognition)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|interpro:IPR037055|reactome:R-RNO-1236974|reactome:R-RNO-1236977|reactome:R-RNO-198933|reactome:R-RNO-6798695|reactome:R-RNO-983170	-	-	-	caution:"The participant EBI-349571(P68370) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919386(Q7TP47) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920972(Q5XIP9) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-916419(P11980) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919578(Q8R491) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920554(Q5U3Z7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920647(Q5U2X8) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920585(Q7TP24) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-779677(P05426) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-915744(P02454) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|agonist:Insulin was shown to increase or decrease GLUT4 protein interactions in specific cases.|comment:"Insulin decreased GLUT4 interactions with the following proteins: Q9ER30 (Sarcosin), P09527 (Rab-7), O88960 (N-ethylmaleimide sensitive), P09456 (PKA I regulatory subunit), P27881 (Hexokinase type II), P07872 (Acyl-coenzyme A oxidase), Q6DGF1 (Isocitrate dehydrogenase), Q9EQX9 (Ubiquitin-conjugating), Q63446 (Polyubiquitin), P24268 (Cathepsin D), Q91XW0 (Heat shock protein 86), Q5FVH0 (unknown), P58405 (Striatin 3), Q62667 (Major vault protein), Q66H50 (unknown), Q09167 (splicing factor), Q9JHU5 (Arfaptin 1)."|comment:"Insulin increased GLUT4 interaction with the following proteins:Q9Z1P2 (R-actinin-1), P45592 (Cofilin), Q9QXQ0 (R-actinin-4), P26473 (ADP-ribosylation factor), P26437 (ADP-ribosylation factor),   Q7TNP1 (Basigin 2), Q6P6R2 (Dihydrolipoamide dehydrogenase),   P04797 (GAPDH), Q63081 (Protein disulfide isomerase), P29457 (47 kDa heat shock protein), Q9R1J8 (Leprecan), O88638 (Putative eps protein),   Q64375 (Synaptonemal complex)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:NDPK - Interactions involving proteins containing InterPro domain IPR001564, Nucleoside diphosphate kinase, core.	taxid:10116(rat-l6)|taxid:10116(Rattus norvegicus)	-	2006/02/15	2021/11/30	rogid:PbFY2lfrty8yw40Jq7ShR7xfuV410116	rogid:WUb0OV1Gb/Pp26dniQIwuxUQB8o10116	intact-crc:44F3A2176D02515F|rigid:9RVm0UBcqQF4k06RGKO89Bg16Q8	false	myc tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P19357	uniprotkb:P97629	intact:EBI-915426|uniprotkb:P97900|ensembl:ENSRNOP00000023256	intact:EBI-918098|uniprotkb:Q11009	psi-mi:glut4_rat(display_long)|uniprotkb:Glucose transporter type 4, insulin-responsive(gene name synonym)|uniprotkb:Slc2a4(gene name)|psi-mi:Slc2a4(display_short)|uniprotkb:Glut4(gene name synonym)	psi-mi:lcap_rat(display_long)|uniprotkb:Oxytocinase(gene name synonym)|uniprotkb:Insulin-regulated membrane aminopeptidase(gene name synonym)|uniprotkb:Insulin-responsive aminopeptidase(gene name synonym)|uniprotkb:Placental leucine aminopeptidase(gene name synonym)|uniprotkb:Vesicle protein of 165 kDa(gene name synonym)|uniprotkb:GP160(gene name synonym)|uniprotkb:Lnpep(gene name)|psi-mi:Lnpep(display_short)|uniprotkb:Irap(gene name synonym)|uniprotkb:Otase(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Foster et al. (2006)	pubmed:16396496|mint:MINT-5218203	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-921030	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2711|refseq:NP_036883.1|refseq:XP_006246658.1|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007611"(learning or memory)|go:"GO:0007614"(short-term memory)|go:"GO:0007616"(long-term memory)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010021"(amylopectin biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031550"(positive regulation of brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044381"(glucose import in response to insulin stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046323"(glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0098694"(regulation of synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0098793"(presynapse)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002441("Glucose transporter, type 4 (GLUT4)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-189200|ensembl:ENSRNOG00000017226(gene)|ensembl:ENSRNOT00000023256(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)	interpro:IPR034016|interpro:IPR034017|interpro:IPR027268|interpro:IPR024571|rgd:621752|refseq:NP_001106874.1|refseq:NP_598258.1|interpro:IPR001930(Peptidase M1, membrane alanine aminopeptidase)|interpro:IPR014782(Peptidase M1, membrane alanine aminopeptidase, N-terminal)|refseq:XP_008757040.1|refseq:XP_017443357.1|interpro:IPR042097|reactome:R-RNO-1236977|reactome:R-RNO-983168|go:"GO:0004177"(aminopeptidase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006508"(proteolysis)|go:"GO:0007165"(signal transduction)|go:"GO:0008217"(regulation of blood pressure)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009725"(response to hormone)|go:"GO:0009986"(cell surface)|go:"GO:0010813"(neuropeptide catabolic process)|go:"GO:0016020"(membrane)|go:"GO:0030163"(protein catabolic process)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031982"(vesicle)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0042277"(peptide binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043171"(peptide catabolic process)|go:"GO:0043229"(intracellular organelle)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045777"(positive regulation of blood pressure)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0060395"(SMAD protein signal transduction)|go:"GO:0070006"(metalloaminopeptidase activity)|go:"GO:0120163"(negative regulation of cold-induced thermogenesis)	-	-	-	caution:"The participant EBI-349571(P68370) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919386(Q7TP47) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920972(Q5XIP9) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-916419(P11980) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919578(Q8R491) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920554(Q5U3Z7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920647(Q5U2X8) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920585(Q7TP24) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-779677(P05426) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-915744(P02454) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|agonist:Insulin was shown to increase or decrease GLUT4 protein interactions in specific cases.|comment:"Insulin decreased GLUT4 interactions with the following proteins: Q9ER30 (Sarcosin), P09527 (Rab-7), O88960 (N-ethylmaleimide sensitive), P09456 (PKA I regulatory subunit), P27881 (Hexokinase type II), P07872 (Acyl-coenzyme A oxidase), Q6DGF1 (Isocitrate dehydrogenase), Q9EQX9 (Ubiquitin-conjugating), Q63446 (Polyubiquitin), P24268 (Cathepsin D), Q91XW0 (Heat shock protein 86), Q5FVH0 (unknown), P58405 (Striatin 3), Q62667 (Major vault protein), Q66H50 (unknown), Q09167 (splicing factor), Q9JHU5 (Arfaptin 1)."|comment:"Insulin increased GLUT4 interaction with the following proteins:Q9Z1P2 (R-actinin-1), P45592 (Cofilin), Q9QXQ0 (R-actinin-4), P26473 (ADP-ribosylation factor), P26437 (ADP-ribosylation factor),   Q7TNP1 (Basigin 2), Q6P6R2 (Dihydrolipoamide dehydrogenase),   P04797 (GAPDH), Q63081 (Protein disulfide isomerase), P29457 (47 kDa heat shock protein), Q9R1J8 (Leprecan), O88638 (Putative eps protein),   Q64375 (Synaptonemal complex)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:NDPK - Interactions involving proteins containing InterPro domain IPR001564, Nucleoside diphosphate kinase, core.	taxid:10116(rat-l6)|taxid:10116(Rattus norvegicus)	-	2006/02/15	2021/11/30	rogid:PbFY2lfrty8yw40Jq7ShR7xfuV410116	rogid:3zV4e3lXuMwdpmkemkRXQZrDugc10116	intact-crc:44F3A2176D02515F|rigid:9RVm0UBcqQF4k06RGKO89Bg16Q8	false	myc tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P19357	uniprotkb:Q6MGB5	intact:EBI-915426|uniprotkb:P97900|ensembl:ENSRNOP00000023256	intact:EBI-918887|ensembl:ENSRNOP00000000542	psi-mi:glut4_rat(display_long)|uniprotkb:Glucose transporter type 4, insulin-responsive(gene name synonym)|uniprotkb:Slc2a4(gene name)|psi-mi:Slc2a4(display_short)|uniprotkb:Glut4(gene name synonym)	psi-mi:dhb8_rat(display_long)|uniprotkb:3-ketoacyl-[acyl-carrier-protein] reductase alpha subunit(gene name synonym)|uniprotkb:Hsd17b8(gene name)|psi-mi:Hsd17b8(display_short)|uniprotkb:Testosterone 17-beta-dehydrogenase 8(gene name synonym)|uniprotkb:17-beta-hydroxysteroid dehydrogenase 8(gene name synonym)|uniprotkb:3-oxoacyl-[acyl-carrier-protein] reductase(gene name synonym)|uniprotkb:Estradiol 17-beta-dehydrogenase 8(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Foster et al. (2006)	pubmed:16396496|mint:MINT-5218203	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-921030	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2711|refseq:NP_036883.1|refseq:XP_006246658.1|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007611"(learning or memory)|go:"GO:0007614"(short-term memory)|go:"GO:0007616"(long-term memory)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010021"(amylopectin biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031550"(positive regulation of brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044381"(glucose import in response to insulin stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046323"(glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0098694"(regulation of synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0098793"(presynapse)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002441("Glucose transporter, type 4 (GLUT4)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-189200|ensembl:ENSRNOG00000017226(gene)|ensembl:ENSRNOT00000023256(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)	rgd:1303158|refseq:NP_997694.1|ensembl:ENSRNOG00000000466(gene)|ensembl:ENSRNOT00000000542(transcript)|go:"GO:0003857"(3-hydroxyacyl-CoA dehydrogenase activity)|go:"GO:0004303"(estradiol 17-beta-dehydrogenase activity)|go:"GO:0005740"(mitochondrial envelope)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005886"(plasma membrane)|go:"GO:0006633"(fatty acid biosynthetic process)|go:"GO:0006703"(estrogen biosynthetic process)|go:"GO:0008209"(androgen metabolic process)|go:"GO:0008210"(estrogen metabolic process)|go:"GO:0016020"(membrane)|go:"GO:0016616"(oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor)|go:"GO:0044594"("17-beta-hydroxysteroid dehydrogenase (NAD+) activity")|go:"GO:0047025"("3-oxoacyl-[acyl-carrier-protein] reductase (NADH) activity")|go:"GO:0047035"("testosterone dehydrogenase (NAD+) activity")|go:"GO:0048038"(quinone binding)|go:"GO:0051290"(protein heterotetramerization)|go:"GO:0070404"(NADH binding)|go:"GO:1990204"(oxidoreductase complex)|interpro:IPR002347(Glucose/ribitol dehydrogenase)|interpro:IPR020904|interpro:IPR036291|reactome:R-RNO-75105	-	-	-	caution:"The participant EBI-349571(P68370) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919386(Q7TP47) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920972(Q5XIP9) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-916419(P11980) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919578(Q8R491) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920554(Q5U3Z7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920647(Q5U2X8) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920585(Q7TP24) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-779677(P05426) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-915744(P02454) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|agonist:Insulin was shown to increase or decrease GLUT4 protein interactions in specific cases.|comment:"Insulin decreased GLUT4 interactions with the following proteins: Q9ER30 (Sarcosin), P09527 (Rab-7), O88960 (N-ethylmaleimide sensitive), P09456 (PKA I regulatory subunit), P27881 (Hexokinase type II), P07872 (Acyl-coenzyme A oxidase), Q6DGF1 (Isocitrate dehydrogenase), Q9EQX9 (Ubiquitin-conjugating), Q63446 (Polyubiquitin), P24268 (Cathepsin D), Q91XW0 (Heat shock protein 86), Q5FVH0 (unknown), P58405 (Striatin 3), Q62667 (Major vault protein), Q66H50 (unknown), Q09167 (splicing factor), Q9JHU5 (Arfaptin 1)."|comment:"Insulin increased GLUT4 interaction with the following proteins:Q9Z1P2 (R-actinin-1), P45592 (Cofilin), Q9QXQ0 (R-actinin-4), P26473 (ADP-ribosylation factor), P26437 (ADP-ribosylation factor),   Q7TNP1 (Basigin 2), Q6P6R2 (Dihydrolipoamide dehydrogenase),   P04797 (GAPDH), Q63081 (Protein disulfide isomerase), P29457 (47 kDa heat shock protein), Q9R1J8 (Leprecan), O88638 (Putative eps protein),   Q64375 (Synaptonemal complex)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:NDPK - Interactions involving proteins containing InterPro domain IPR001564, Nucleoside diphosphate kinase, core.	taxid:10116(rat-l6)|taxid:10116(Rattus norvegicus)	-	2006/02/15	2021/11/30	rogid:PbFY2lfrty8yw40Jq7ShR7xfuV410116	rogid:eKePURXwYUBXT8/RcuopySLJTyM10116	intact-crc:44F3A2176D02515F|rigid:9RVm0UBcqQF4k06RGKO89Bg16Q8	false	myc tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P19357	uniprotkb:Q6MG76	intact:EBI-915426|uniprotkb:P97900|ensembl:ENSRNOP00000023256	intact:EBI-918873|uniprotkb:F1LP39	psi-mi:glut4_rat(display_long)|uniprotkb:Glucose transporter type 4, insulin-responsive(gene name synonym)|uniprotkb:Slc2a4(gene name)|psi-mi:Slc2a4(display_short)|uniprotkb:Glut4(gene name synonym)	psi-mi:q6mg76_rat(display_long)|uniprotkb:Apom(gene name synonym)|uniprotkb:Bat4(gene name synonym)|uniprotkb:C2(gene name synonym)|uniprotkb:C4a(gene name synonym)|uniprotkb:Cfb(gene name synonym)|uniprotkb:Csnk2b(gene name synonym)|uniprotkb:G7e(gene name synonym)|uniprotkb:Hspa1a(gene name synonym)|uniprotkb:Hspa1b(gene name synonym)|uniprotkb:Ly6g5c(gene name synonym)|uniprotkb:Ly6g6c(gene name synonym)|uniprotkb:Neu1(gene name synonym)|uniprotkb:Ng35(gene name synonym)|uniprotkb:Rps25-ps2(gene name synonym)|uniprotkb:Skiv2l(gene name)|psi-mi:Skiv2l(display_short)|uniprotkb:Hspa1l(gene name synonym)|uniprotkb:Stk19(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Foster et al. (2006)	pubmed:16396496|mint:MINT-5218203	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-921030	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2711|refseq:NP_036883.1|refseq:XP_006246658.1|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007611"(learning or memory)|go:"GO:0007614"(short-term memory)|go:"GO:0007616"(long-term memory)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010021"(amylopectin biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031550"(positive regulation of brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044381"(glucose import in response to insulin stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046323"(glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0098694"(regulation of synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0098793"(presynapse)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002441("Glucose transporter, type 4 (GLUT4)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-189200|ensembl:ENSRNOG00000017226(gene)|ensembl:ENSRNOT00000023256(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)	rgd:1303059|refseq:NP_998724.1|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR011545(DNA/RNA helicase, DEAD/DEAH box type, N-terminal)|interpro:IPR012961(DSH, C-terminal)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR016438(RNA helicase, ATP-dependent, SK12/DOB1)|interpro:IPR040801|interpro:IPR025696|interpro:IPR027417|go:"GO:0003723"(RNA binding)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0006401"(RNA catabolic process)|go:"GO:0016787"(hydrolase activity)|go:"GO:0055087"(Ski complex)|go:"GO:0070478"(nuclear-transcribed mRNA catabolic process, 3'-5' exonucleolytic nonsense-mediated decay)	-	-	-	caution:"The participant EBI-349571(P68370) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919386(Q7TP47) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920972(Q5XIP9) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-916419(P11980) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919578(Q8R491) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920554(Q5U3Z7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920647(Q5U2X8) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920585(Q7TP24) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-779677(P05426) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-915744(P02454) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|agonist:Insulin was shown to increase or decrease GLUT4 protein interactions in specific cases.|comment:"Insulin decreased GLUT4 interactions with the following proteins: Q9ER30 (Sarcosin), P09527 (Rab-7), O88960 (N-ethylmaleimide sensitive), P09456 (PKA I regulatory subunit), P27881 (Hexokinase type II), P07872 (Acyl-coenzyme A oxidase), Q6DGF1 (Isocitrate dehydrogenase), Q9EQX9 (Ubiquitin-conjugating), Q63446 (Polyubiquitin), P24268 (Cathepsin D), Q91XW0 (Heat shock protein 86), Q5FVH0 (unknown), P58405 (Striatin 3), Q62667 (Major vault protein), Q66H50 (unknown), Q09167 (splicing factor), Q9JHU5 (Arfaptin 1)."|comment:"Insulin increased GLUT4 interaction with the following proteins:Q9Z1P2 (R-actinin-1), P45592 (Cofilin), Q9QXQ0 (R-actinin-4), P26473 (ADP-ribosylation factor), P26437 (ADP-ribosylation factor),   Q7TNP1 (Basigin 2), Q6P6R2 (Dihydrolipoamide dehydrogenase),   P04797 (GAPDH), Q63081 (Protein disulfide isomerase), P29457 (47 kDa heat shock protein), Q9R1J8 (Leprecan), O88638 (Putative eps protein),   Q64375 (Synaptonemal complex)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:NDPK - Interactions involving proteins containing InterPro domain IPR001564, Nucleoside diphosphate kinase, core.	taxid:10116(rat-l6)|taxid:10116(Rattus norvegicus)	-	2006/02/15	2021/11/30	rogid:PbFY2lfrty8yw40Jq7ShR7xfuV410116	rogid:IJS09dBklrDhfh6+HDNEfsTBwbI10116	intact-crc:44F3A2176D02515F|rigid:9RVm0UBcqQF4k06RGKO89Bg16Q8	false	myc tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P19357	uniprotkb:P55063	intact:EBI-915426|uniprotkb:P97900|ensembl:ENSRNOP00000023256	intact:EBI-918863|uniprotkb:Q32P36|uniprotkb:Q6MG67|ensembl:ENSRNOP00000063974	psi-mi:glut4_rat(display_long)|uniprotkb:Glucose transporter type 4, insulin-responsive(gene name synonym)|uniprotkb:Slc2a4(gene name)|psi-mi:Slc2a4(display_short)|uniprotkb:Glut4(gene name synonym)	psi-mi:hs71l_rat(display_long)|uniprotkb:Heat shock 70 kDa protein 3(gene name synonym)|uniprotkb:Hspa1l(gene name)|psi-mi:Hspa1l(display_short)|uniprotkb:Hsp70-3(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Foster et al. (2006)	pubmed:16396496|mint:MINT-5218203	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-921030	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2711|refseq:NP_036883.1|refseq:XP_006246658.1|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007611"(learning or memory)|go:"GO:0007614"(short-term memory)|go:"GO:0007616"(long-term memory)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010021"(amylopectin biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031550"(positive regulation of brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044381"(glucose import in response to insulin stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046323"(glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0098694"(regulation of synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0098793"(presynapse)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002441("Glucose transporter, type 4 (GLUT4)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-189200|ensembl:ENSRNOG00000017226(gene)|ensembl:ENSRNOT00000023256(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)	rgd:1595925|refseq:NP_997711.1|refseq:XP_017457033.1|ensembl:ENSRNOG00000047966(gene)|ensembl:ENSRNOT00000074223(transcript)|go:"GO:0002199"(zona pellucida receptor complex)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007339"(binding of sperm to zona pellucida)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0034620"(cellular response to unfolded protein)|go:"GO:0042026"(protein refolding)|go:"GO:0044183"(protein folding chaperone)|go:"GO:0044297"(cell body)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051085"(chaperone cofactor-dependent protein refolding)|go:"GO:0051787"(misfolded protein binding)|go:"GO:1903955"(positive regulation of protein targeting to mitochondrion)|interpro:IPR013126(Heat shock protein 70)|interpro:IPR018181|interpro:IPR029047|interpro:IPR029048|interpro:IPR043129|mint:P55063|reactome:R-RNO-3371453|reactome:R-RNO-3371497|reactome:R-RNO-3371568|reactome:R-RNO-3371571	-	-	-	caution:"The participant EBI-349571(P68370) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919386(Q7TP47) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920972(Q5XIP9) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-916419(P11980) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919578(Q8R491) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920554(Q5U3Z7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920647(Q5U2X8) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920585(Q7TP24) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-779677(P05426) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-915744(P02454) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|agonist:Insulin was shown to increase or decrease GLUT4 protein interactions in specific cases.|comment:"Insulin decreased GLUT4 interactions with the following proteins: Q9ER30 (Sarcosin), P09527 (Rab-7), O88960 (N-ethylmaleimide sensitive), P09456 (PKA I regulatory subunit), P27881 (Hexokinase type II), P07872 (Acyl-coenzyme A oxidase), Q6DGF1 (Isocitrate dehydrogenase), Q9EQX9 (Ubiquitin-conjugating), Q63446 (Polyubiquitin), P24268 (Cathepsin D), Q91XW0 (Heat shock protein 86), Q5FVH0 (unknown), P58405 (Striatin 3), Q62667 (Major vault protein), Q66H50 (unknown), Q09167 (splicing factor), Q9JHU5 (Arfaptin 1)."|comment:"Insulin increased GLUT4 interaction with the following proteins:Q9Z1P2 (R-actinin-1), P45592 (Cofilin), Q9QXQ0 (R-actinin-4), P26473 (ADP-ribosylation factor), P26437 (ADP-ribosylation factor),   Q7TNP1 (Basigin 2), Q6P6R2 (Dihydrolipoamide dehydrogenase),   P04797 (GAPDH), Q63081 (Protein disulfide isomerase), P29457 (47 kDa heat shock protein), Q9R1J8 (Leprecan), O88638 (Putative eps protein),   Q64375 (Synaptonemal complex)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:NDPK - Interactions involving proteins containing InterPro domain IPR001564, Nucleoside diphosphate kinase, core.	taxid:10116(rat-l6)|taxid:10116(Rattus norvegicus)	-	2006/02/15	2021/11/30	rogid:PbFY2lfrty8yw40Jq7ShR7xfuV410116	rogid:jBu6RUqH2VpyJdBAuEXR+R1oe1w10116	intact-crc:44F3A2176D02515F|rigid:9RVm0UBcqQF4k06RGKO89Bg16Q8	false	myc tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P19357	uniprotkb:Q6MG60	intact:EBI-915426|uniprotkb:P97900|ensembl:ENSRNOP00000023256	intact:EBI-918857|ensembl:ENSRNOP00000001118|ensembl:ENSRNOP00000068864|ensembl:ENSRNOP00000069121	psi-mi:glut4_rat(display_long)|uniprotkb:Glucose transporter type 4, insulin-responsive(gene name synonym)|uniprotkb:Slc2a4(gene name)|psi-mi:Slc2a4(display_short)|uniprotkb:Glut4(gene name synonym)	psi-mi:ddah2_rat(display_long)|uniprotkb:DDAHII(gene name synonym)|uniprotkb:Dimethylargininase-2(gene name synonym)|uniprotkb:Ddah2(gene name)|psi-mi:Ddah2(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Foster et al. (2006)	pubmed:16396496|mint:MINT-5218203	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-921030	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2711|refseq:NP_036883.1|refseq:XP_006246658.1|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007611"(learning or memory)|go:"GO:0007614"(short-term memory)|go:"GO:0007616"(long-term memory)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010021"(amylopectin biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031550"(positive regulation of brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044381"(glucose import in response to insulin stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046323"(glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0098694"(regulation of synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0098793"(presynapse)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002441("Glucose transporter, type 4 (GLUT4)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-189200|ensembl:ENSRNOG00000017226(gene)|ensembl:ENSRNOT00000023256(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)	rgd:1302955|refseq:NP_001159408.1|refseq:NP_997697.1|ensembl:ENSRNOG00000000842(gene)|ensembl:ENSRNOT00000001118(transcript)|ensembl:ENSRNOT00000083353(transcript)|ensembl:ENSRNOT00000088251(transcript)|go:"GO:0000052"(citrulline metabolic process)|go:"GO:0005739"(mitochondrion)|go:"GO:0006525"(arginine metabolic process)|go:"GO:0006527"(arginine catabolic process)|go:"GO:0016403"(dimethylargininase activity)|go:"GO:0016597"(amino acid binding)|go:"GO:0045429"(positive regulation of nitric oxide biosynthetic process)|interpro:IPR033199|interpro:IPR033202|reactome:R-RNO-203615	-	-	-	caution:"The participant EBI-349571(P68370) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919386(Q7TP47) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920972(Q5XIP9) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-916419(P11980) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919578(Q8R491) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920554(Q5U3Z7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920647(Q5U2X8) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920585(Q7TP24) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-779677(P05426) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-915744(P02454) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|agonist:Insulin was shown to increase or decrease GLUT4 protein interactions in specific cases.|comment:"Insulin decreased GLUT4 interactions with the following proteins: Q9ER30 (Sarcosin), P09527 (Rab-7), O88960 (N-ethylmaleimide sensitive), P09456 (PKA I regulatory subunit), P27881 (Hexokinase type II), P07872 (Acyl-coenzyme A oxidase), Q6DGF1 (Isocitrate dehydrogenase), Q9EQX9 (Ubiquitin-conjugating), Q63446 (Polyubiquitin), P24268 (Cathepsin D), Q91XW0 (Heat shock protein 86), Q5FVH0 (unknown), P58405 (Striatin 3), Q62667 (Major vault protein), Q66H50 (unknown), Q09167 (splicing factor), Q9JHU5 (Arfaptin 1)."|comment:"Insulin increased GLUT4 interaction with the following proteins:Q9Z1P2 (R-actinin-1), P45592 (Cofilin), Q9QXQ0 (R-actinin-4), P26473 (ADP-ribosylation factor), P26437 (ADP-ribosylation factor),   Q7TNP1 (Basigin 2), Q6P6R2 (Dihydrolipoamide dehydrogenase),   P04797 (GAPDH), Q63081 (Protein disulfide isomerase), P29457 (47 kDa heat shock protein), Q9R1J8 (Leprecan), O88638 (Putative eps protein),   Q64375 (Synaptonemal complex)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:NDPK - Interactions involving proteins containing InterPro domain IPR001564, Nucleoside diphosphate kinase, core.	taxid:10116(rat-l6)|taxid:10116(Rattus norvegicus)	-	2006/02/15	2021/11/30	rogid:PbFY2lfrty8yw40Jq7ShR7xfuV410116	rogid:7lqVoEKMeDTHQhVGnna73ZPHI+Y10116	intact-crc:44F3A2176D02515F|rigid:9RVm0UBcqQF4k06RGKO89Bg16Q8	false	myc tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P19357	uniprotkb:Q6MG30	intact:EBI-915426|uniprotkb:P97900|ensembl:ENSRNOP00000023256	intact:EBI-918845	psi-mi:glut4_rat(display_long)|uniprotkb:Glucose transporter type 4, insulin-responsive(gene name synonym)|uniprotkb:Slc2a4(gene name)|psi-mi:Slc2a4(display_short)|uniprotkb:Glut4(gene name synonym)	psi-mi:q6mg30_rat(display_long)|uniprotkb:Cdk2ap1-ps7(gene name synonym)|uniprotkb:Cdk2ap1-ps8(gene name synonym)|uniprotkb:Ddr1(gene name synonym)|uniprotkb:E030032D13Rik(gene name synonym)|uniprotkb:LOC224733l-9(gene name synonym)|uniprotkb:RT1-CE14(gene name)|psi-mi:RT1-CE14(display_short)|uniprotkb:RT1-CE16(gene name synonym)|uniprotkb:Tcf19(gene name synonym)|uniprotkb:Rpl22-ps(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Foster et al. (2006)	pubmed:16396496|mint:MINT-5218203	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-921030	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2711|refseq:NP_036883.1|refseq:XP_006246658.1|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007611"(learning or memory)|go:"GO:0007614"(short-term memory)|go:"GO:0007616"(long-term memory)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010021"(amylopectin biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031550"(positive regulation of brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044381"(glucose import in response to insulin stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046323"(glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0098694"(regulation of synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0098793"(presynapse)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002441("Glucose transporter, type 4 (GLUT4)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-189200|ensembl:ENSRNOG00000017226(gene)|ensembl:ENSRNOT00000023256(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)	rgd:1359342|refseq:NP_001008837.1|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR003006(Immunoglobulin/major histocompatibility complex, conserved site)|interpro:IPR003597(Immunoglobulin C1-set)|interpro:IPR011161(MHC class I-like antigen recognition)|interpro:IPR011162(MHC classes I and II-like antigen recognition)|interpro:IPR001039(MHC class I, alpha chain, alpha1 and alpha2)|interpro:IPR036179|interpro:IPR037055|go:"GO:0016021"(integral component of membrane)	-	-	-	caution:"The participant EBI-349571(P68370) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919386(Q7TP47) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920972(Q5XIP9) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-916419(P11980) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919578(Q8R491) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920554(Q5U3Z7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920647(Q5U2X8) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920585(Q7TP24) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-779677(P05426) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-915744(P02454) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|agonist:Insulin was shown to increase or decrease GLUT4 protein interactions in specific cases.|comment:"Insulin decreased GLUT4 interactions with the following proteins: Q9ER30 (Sarcosin), P09527 (Rab-7), O88960 (N-ethylmaleimide sensitive), P09456 (PKA I regulatory subunit), P27881 (Hexokinase type II), P07872 (Acyl-coenzyme A oxidase), Q6DGF1 (Isocitrate dehydrogenase), Q9EQX9 (Ubiquitin-conjugating), Q63446 (Polyubiquitin), P24268 (Cathepsin D), Q91XW0 (Heat shock protein 86), Q5FVH0 (unknown), P58405 (Striatin 3), Q62667 (Major vault protein), Q66H50 (unknown), Q09167 (splicing factor), Q9JHU5 (Arfaptin 1)."|comment:"Insulin increased GLUT4 interaction with the following proteins:Q9Z1P2 (R-actinin-1), P45592 (Cofilin), Q9QXQ0 (R-actinin-4), P26473 (ADP-ribosylation factor), P26437 (ADP-ribosylation factor),   Q7TNP1 (Basigin 2), Q6P6R2 (Dihydrolipoamide dehydrogenase),   P04797 (GAPDH), Q63081 (Protein disulfide isomerase), P29457 (47 kDa heat shock protein), Q9R1J8 (Leprecan), O88638 (Putative eps protein),   Q64375 (Synaptonemal complex)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:NDPK - Interactions involving proteins containing InterPro domain IPR001564, Nucleoside diphosphate kinase, core.	taxid:10116(rat-l6)|taxid:10116(Rattus norvegicus)	-	2006/02/15	2021/11/30	rogid:PbFY2lfrty8yw40Jq7ShR7xfuV410116	rogid:hkAqDRCPNsKMKqtCvF5lzr6sWjU10116	intact-crc:44F3A2176D02515F|rigid:9RVm0UBcqQF4k06RGKO89Bg16Q8	false	myc tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P19357	uniprotkb:Q6LED0	intact:EBI-915426|uniprotkb:P97900|ensembl:ENSRNOP00000023256	intact:EBI-918833|ensembl:ENSRNOP00000064431|ensembl:ENSRNOP00000067217|ensembl:ENSRNOP00000069899|ensembl:ENSRNOP00000074909	psi-mi:glut4_rat(display_long)|uniprotkb:Glucose transporter type 4, insulin-responsive(gene name synonym)|uniprotkb:Slc2a4(gene name)|psi-mi:Slc2a4(display_short)|uniprotkb:Glut4(gene name synonym)	psi-mi:h31_rat(display_long)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Foster et al. (2006)	pubmed:16396496|mint:MINT-5218203	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-921030	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2711|refseq:NP_036883.1|refseq:XP_006246658.1|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007611"(learning or memory)|go:"GO:0007614"(short-term memory)|go:"GO:0007616"(long-term memory)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010021"(amylopectin biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031550"(positive regulation of brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044381"(glucose import in response to insulin stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046323"(glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0098694"(regulation of synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0098793"(presynapse)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002441("Glucose transporter, type 4 (GLUT4)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-189200|ensembl:ENSRNOG00000017226(gene)|ensembl:ENSRNOT00000023256(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)	refseq:NP_001013074.1|refseq:XP_017443213.1|refseq:XP_017443230.1|refseq:XP_017456209.1|ensembl:ENSRNOG00000046144(gene)|ensembl:ENSRNOG00000046434(gene)|ensembl:ENSRNOG00000054539(gene)|ensembl:ENSRNOG00000056281(gene)|ensembl:ENSRNOT00000072019(transcript)|ensembl:ENSRNOT00000073188(transcript)|ensembl:ENSRNOT00000079880(transcript)|ensembl:ENSRNOT00000083417(transcript)|go:"GO:0000786"(nucleosome)|go:"GO:0003677"(DNA binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0046982"(protein heterodimerization activity)|interpro:IPR000164(Histone H3)|interpro:IPR007125(Histone core)|interpro:IPR009072(Histone-fold)|reactome:R-RNO-1266695|reactome:R-RNO-201722|reactome:R-RNO-212300|reactome:R-RNO-2299718|reactome:R-RNO-2559580|reactome:R-RNO-2559582|reactome:R-RNO-3214841|reactome:R-RNO-3214842|reactome:R-RNO-3214847|reactome:R-RNO-3214858|reactome:R-RNO-3247509|reactome:R-RNO-427359|reactome:R-RNO-427413|reactome:R-RNO-5250924|reactome:R-RNO-5578749|reactome:R-RNO-5625886|reactome:R-RNO-73728|reactome:R-RNO-73772|reactome:R-RNO-8936459|reactome:R-RNO-9018519|reactome:R-RNO-983231	-	-	-	caution:"The participant EBI-349571(P68370) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919386(Q7TP47) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920972(Q5XIP9) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-916419(P11980) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919578(Q8R491) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920554(Q5U3Z7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920647(Q5U2X8) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920585(Q7TP24) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-779677(P05426) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-915744(P02454) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|agonist:Insulin was shown to increase or decrease GLUT4 protein interactions in specific cases.|comment:"Insulin decreased GLUT4 interactions with the following proteins: Q9ER30 (Sarcosin), P09527 (Rab-7), O88960 (N-ethylmaleimide sensitive), P09456 (PKA I regulatory subunit), P27881 (Hexokinase type II), P07872 (Acyl-coenzyme A oxidase), Q6DGF1 (Isocitrate dehydrogenase), Q9EQX9 (Ubiquitin-conjugating), Q63446 (Polyubiquitin), P24268 (Cathepsin D), Q91XW0 (Heat shock protein 86), Q5FVH0 (unknown), P58405 (Striatin 3), Q62667 (Major vault protein), Q66H50 (unknown), Q09167 (splicing factor), Q9JHU5 (Arfaptin 1)."|comment:"Insulin increased GLUT4 interaction with the following proteins:Q9Z1P2 (R-actinin-1), P45592 (Cofilin), Q9QXQ0 (R-actinin-4), P26473 (ADP-ribosylation factor), P26437 (ADP-ribosylation factor),   Q7TNP1 (Basigin 2), Q6P6R2 (Dihydrolipoamide dehydrogenase),   P04797 (GAPDH), Q63081 (Protein disulfide isomerase), P29457 (47 kDa heat shock protein), Q9R1J8 (Leprecan), O88638 (Putative eps protein),   Q64375 (Synaptonemal complex)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:NDPK - Interactions involving proteins containing InterPro domain IPR001564, Nucleoside diphosphate kinase, core.	taxid:10116(rat-l6)|taxid:10116(Rattus norvegicus)	-	2006/02/15	2021/11/30	rogid:PbFY2lfrty8yw40Jq7ShR7xfuV410116	rogid:ood0OohxZHuhsWZtO7U7GMc+LwM10116	intact-crc:44F3A2176D02515F|rigid:9RVm0UBcqQF4k06RGKO89Bg16Q8	false	myc tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P19357	uniprotkb:Q6J4T4	intact:EBI-915426|uniprotkb:P97900|ensembl:ENSRNOP00000023256	intact:EBI-918829	psi-mi:glut4_rat(display_long)|uniprotkb:Glucose transporter type 4, insulin-responsive(gene name synonym)|uniprotkb:Slc2a4(gene name)|psi-mi:Slc2a4(display_short)|uniprotkb:Glut4(gene name synonym)	psi-mi:q6j4t4_rat(display_long)|uniprotkb:Eplin(gene name)|psi-mi:Eplin(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Foster et al. (2006)	pubmed:16396496|mint:MINT-5218203	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-921030	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2711|refseq:NP_036883.1|refseq:XP_006246658.1|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007611"(learning or memory)|go:"GO:0007614"(short-term memory)|go:"GO:0007616"(long-term memory)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010021"(amylopectin biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031550"(positive regulation of brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044381"(glucose import in response to insulin stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046323"(glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0098694"(regulation of synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0098793"(presynapse)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002441("Glucose transporter, type 4 (GLUT4)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-189200|ensembl:ENSRNOG00000017226(gene)|ensembl:ENSRNOT00000023256(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)	interpro:IPR028740|go:"GO:0030835"(negative regulation of actin filament depolymerization)|go:"GO:0051015"(actin filament binding)|go:"GO:0051017"(actin filament bundle assembly)	-	-	-	caution:"The participant EBI-349571(P68370) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919386(Q7TP47) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920972(Q5XIP9) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-916419(P11980) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919578(Q8R491) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920554(Q5U3Z7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920647(Q5U2X8) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920585(Q7TP24) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-779677(P05426) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-915744(P02454) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|agonist:Insulin was shown to increase or decrease GLUT4 protein interactions in specific cases.|comment:"Insulin decreased GLUT4 interactions with the following proteins: Q9ER30 (Sarcosin), P09527 (Rab-7), O88960 (N-ethylmaleimide sensitive), P09456 (PKA I regulatory subunit), P27881 (Hexokinase type II), P07872 (Acyl-coenzyme A oxidase), Q6DGF1 (Isocitrate dehydrogenase), Q9EQX9 (Ubiquitin-conjugating), Q63446 (Polyubiquitin), P24268 (Cathepsin D), Q91XW0 (Heat shock protein 86), Q5FVH0 (unknown), P58405 (Striatin 3), Q62667 (Major vault protein), Q66H50 (unknown), Q09167 (splicing factor), Q9JHU5 (Arfaptin 1)."|comment:"Insulin increased GLUT4 interaction with the following proteins:Q9Z1P2 (R-actinin-1), P45592 (Cofilin), Q9QXQ0 (R-actinin-4), P26473 (ADP-ribosylation factor), P26437 (ADP-ribosylation factor),   Q7TNP1 (Basigin 2), Q6P6R2 (Dihydrolipoamide dehydrogenase),   P04797 (GAPDH), Q63081 (Protein disulfide isomerase), P29457 (47 kDa heat shock protein), Q9R1J8 (Leprecan), O88638 (Putative eps protein),   Q64375 (Synaptonemal complex)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:NDPK - Interactions involving proteins containing InterPro domain IPR001564, Nucleoside diphosphate kinase, core.	taxid:10116(rat-l6)|taxid:10116(Rattus norvegicus)	-	2006/02/15	2021/11/30	rogid:PbFY2lfrty8yw40Jq7ShR7xfuV410116	rogid:al9LguM93YgNtbnc3LCTvX5rAsw10116	intact-crc:44F3A2176D02515F|rigid:9RVm0UBcqQF4k06RGKO89Bg16Q8	false	myc tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P19357	uniprotkb:Q62636	intact:EBI-915426|uniprotkb:P97900|ensembl:ENSRNOP00000023256	intact:EBI-918821|uniprotkb:Q6J167|ensembl:ENSRNOP00000009511	psi-mi:glut4_rat(display_long)|uniprotkb:Glucose transporter type 4, insulin-responsive(gene name synonym)|uniprotkb:Slc2a4(gene name)|psi-mi:Slc2a4(display_short)|uniprotkb:Glut4(gene name synonym)	psi-mi:rap1b_rat(display_long)|uniprotkb:GTP-binding protein smg p21B(gene name synonym)|uniprotkb:Rap1b(gene name)|psi-mi:Rap1b(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Foster et al. (2006)	pubmed:16396496|mint:MINT-5218203	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-921030	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2711|refseq:NP_036883.1|refseq:XP_006246658.1|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007611"(learning or memory)|go:"GO:0007614"(short-term memory)|go:"GO:0007616"(long-term memory)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010021"(amylopectin biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031550"(positive regulation of brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044381"(glucose import in response to insulin stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046323"(glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0098694"(regulation of synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0098793"(presynapse)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002441("Glucose transporter, type 4 (GLUT4)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-189200|ensembl:ENSRNOG00000017226(gene)|ensembl:ENSRNOT00000023256(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)	rgd:620577|refseq:NP_599173.2|refseq:XP_008763599.1|ensembl:ENSRNOG00000007048(gene)|ensembl:ENSRNOT00000009511(transcript)|go:"GO:0003924"(GTPase activity)|go:"GO:0003925"(G protein activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005811"(lipid droplet)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0008283"(cell population proliferation)|go:"GO:0009743"(response to carbohydrate)|go:"GO:0019003"(GDP binding)|go:"GO:0032486"(Rap protein signal transduction)|go:"GO:0033625"(positive regulation of integrin activation)|go:"GO:0035690"|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045955"(negative regulation of calcium ion-dependent exocytosis)|go:"GO:0061028"(establishment of endothelial barrier)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071320"(cellular response to cAMP)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0097211"(cellular response to gonadotropin-releasing hormone)|go:"GO:1901888"(regulation of cell junction assembly)|go:"GO:2000114"(regulation of establishment of cell polarity)|go:"GO:2000301"(negative regulation of synaptic vesicle exocytosis)|interpro:IPR001806(Ras GTPase)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR020849|interpro:IPR027417|interpro:IPR038851|rcsb pdb:3X1W|rcsb pdb:3X1X|rcsb pdb:3X1Y|rcsb pdb:3X1Z|reactome:R-RNO-354192|reactome:R-RNO-354194|reactome:R-RNO-372708|reactome:R-RNO-392517|reactome:R-RNO-5674135|reactome:R-RNO-6798695|reactome:R-RNO-8875555	-	-	-	caution:"The participant EBI-349571(P68370) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919386(Q7TP47) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920972(Q5XIP9) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-916419(P11980) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919578(Q8R491) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920554(Q5U3Z7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920647(Q5U2X8) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920585(Q7TP24) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-779677(P05426) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-915744(P02454) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|agonist:Insulin was shown to increase or decrease GLUT4 protein interactions in specific cases.|comment:"Insulin decreased GLUT4 interactions with the following proteins: Q9ER30 (Sarcosin), P09527 (Rab-7), O88960 (N-ethylmaleimide sensitive), P09456 (PKA I regulatory subunit), P27881 (Hexokinase type II), P07872 (Acyl-coenzyme A oxidase), Q6DGF1 (Isocitrate dehydrogenase), Q9EQX9 (Ubiquitin-conjugating), Q63446 (Polyubiquitin), P24268 (Cathepsin D), Q91XW0 (Heat shock protein 86), Q5FVH0 (unknown), P58405 (Striatin 3), Q62667 (Major vault protein), Q66H50 (unknown), Q09167 (splicing factor), Q9JHU5 (Arfaptin 1)."|comment:"Insulin increased GLUT4 interaction with the following proteins:Q9Z1P2 (R-actinin-1), P45592 (Cofilin), Q9QXQ0 (R-actinin-4), P26473 (ADP-ribosylation factor), P26437 (ADP-ribosylation factor),   Q7TNP1 (Basigin 2), Q6P6R2 (Dihydrolipoamide dehydrogenase),   P04797 (GAPDH), Q63081 (Protein disulfide isomerase), P29457 (47 kDa heat shock protein), Q9R1J8 (Leprecan), O88638 (Putative eps protein),   Q64375 (Synaptonemal complex)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:NDPK - Interactions involving proteins containing InterPro domain IPR001564, Nucleoside diphosphate kinase, core.	taxid:10116(rat-l6)|taxid:10116(Rattus norvegicus)	-	2006/02/15	2021/11/30	rogid:PbFY2lfrty8yw40Jq7ShR7xfuV410116	rogid:Sa2RvwmbQkQ6KM2V7xiawl5uytg10116	intact-crc:44F3A2176D02515F|rigid:9RVm0UBcqQF4k06RGKO89Bg16Q8	false	myc tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P19357	uniprotkb:Q6IRE4	intact:EBI-915426|uniprotkb:P97900|ensembl:ENSRNOP00000023256	intact:EBI-918814|uniprotkb:Q7TSE5|ensembl:ENSRNOP00000018194	psi-mi:glut4_rat(display_long)|uniprotkb:Glucose transporter type 4, insulin-responsive(gene name synonym)|uniprotkb:Slc2a4(gene name)|psi-mi:Slc2a4(display_short)|uniprotkb:Glut4(gene name synonym)	psi-mi:ts101_rat(display_long)|uniprotkb:Tsg101(gene name)|psi-mi:Tsg101(display_short)|uniprotkb:ESCRT-I complex subunit TSG101(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Foster et al. (2006)	pubmed:16396496|mint:MINT-5218203	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-921030	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2711|refseq:NP_036883.1|refseq:XP_006246658.1|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007611"(learning or memory)|go:"GO:0007614"(short-term memory)|go:"GO:0007616"(long-term memory)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010021"(amylopectin biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031550"(positive regulation of brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044381"(glucose import in response to insulin stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046323"(glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0098694"(regulation of synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0098793"(presynapse)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002441("Glucose transporter, type 4 (GLUT4)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-189200|ensembl:ENSRNOG00000017226(gene)|ensembl:ENSRNOT00000023256(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)	rgd:3909|refseq:NP_853659.2|ensembl:ENSRNOG00000013381(gene)|ensembl:ENSRNOT00000018194(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000813"(ESCRT I complex)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005769"(early endosome)|go:"GO:0005770"(late endosome)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006513"(protein monoubiquitination)|go:"GO:0006858"(extracellular transport)|go:"GO:0007049"(cell cycle)|go:"GO:0007175"(negative regulation of epidermal growth factor-activated receptor activity)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008333"(endosome to lysosome transport)|go:"GO:0010008"(endosome membrane)|go:"GO:0015031"(protein transport)|go:"GO:0030154"(cell differentiation)|go:"GO:0030216"(keratinocyte differentiation)|go:"GO:0030374"(nuclear receptor coactivator activity)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031901"(early endosome membrane)|go:"GO:0031902"(late endosome membrane)|go:"GO:0042059"(negative regulation of epidermal growth factor receptor signaling pathway)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0043162"(ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway)|go:"GO:0043405"(regulation of MAP kinase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046755"(viral budding)|go:"GO:0046790"(virion binding)|go:"GO:0048306"(calcium-dependent protein binding)|go:"GO:0051301"(cell division)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0070062"(extracellular exosome)|go:"GO:0090543"(Flemming body)|go:"GO:1902188"(obsolete positive regulation of viral release from host cell)|go:"GO:1903543"(positive regulation of exosomal secretion)|go:"GO:1903551"(regulation of extracellular exosome assembly)|go:"GO:1903774"(positive regulation of viral budding via host ESCRT complex)|go:"GO:1990182"(exosomal secretion)|go:"GO:2000397"(positive regulation of ubiquitin-dependent endocytosis)|interpro:IPR008883(Tumour susceptibility gene 101)|interpro:IPR016135(Ubiquitin-conjugating enzyme/RWD-like)|interpro:IPR017916|interpro:IPR037202|reactome:R-RNO-917729	-	-	-	caution:"The participant EBI-349571(P68370) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919386(Q7TP47) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920972(Q5XIP9) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-916419(P11980) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919578(Q8R491) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920554(Q5U3Z7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920647(Q5U2X8) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920585(Q7TP24) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-779677(P05426) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-915744(P02454) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|agonist:Insulin was shown to increase or decrease GLUT4 protein interactions in specific cases.|comment:"Insulin decreased GLUT4 interactions with the following proteins: Q9ER30 (Sarcosin), P09527 (Rab-7), O88960 (N-ethylmaleimide sensitive), P09456 (PKA I regulatory subunit), P27881 (Hexokinase type II), P07872 (Acyl-coenzyme A oxidase), Q6DGF1 (Isocitrate dehydrogenase), Q9EQX9 (Ubiquitin-conjugating), Q63446 (Polyubiquitin), P24268 (Cathepsin D), Q91XW0 (Heat shock protein 86), Q5FVH0 (unknown), P58405 (Striatin 3), Q62667 (Major vault protein), Q66H50 (unknown), Q09167 (splicing factor), Q9JHU5 (Arfaptin 1)."|comment:"Insulin increased GLUT4 interaction with the following proteins:Q9Z1P2 (R-actinin-1), P45592 (Cofilin), Q9QXQ0 (R-actinin-4), P26473 (ADP-ribosylation factor), P26437 (ADP-ribosylation factor),   Q7TNP1 (Basigin 2), Q6P6R2 (Dihydrolipoamide dehydrogenase),   P04797 (GAPDH), Q63081 (Protein disulfide isomerase), P29457 (47 kDa heat shock protein), Q9R1J8 (Leprecan), O88638 (Putative eps protein),   Q64375 (Synaptonemal complex)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:NDPK - Interactions involving proteins containing InterPro domain IPR001564, Nucleoside diphosphate kinase, core.	taxid:10116(rat-l6)|taxid:10116(Rattus norvegicus)	-	2006/02/15	2021/11/30	rogid:PbFY2lfrty8yw40Jq7ShR7xfuV410116	rogid:rodpheLsl1WzF7xQa5d+Tf2gKBE10116	intact-crc:44F3A2176D02515F|rigid:9RVm0UBcqQF4k06RGKO89Bg16Q8	false	myc tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P19357	uniprotkb:Q66X93	intact:EBI-915426|uniprotkb:P97900|ensembl:ENSRNOP00000023256	intact:EBI-918802|uniprotkb:P97693|uniprotkb:Q6IN40|ensembl:ENSRNOP00000041531	psi-mi:glut4_rat(display_long)|uniprotkb:Glucose transporter type 4, insulin-responsive(gene name synonym)|uniprotkb:Slc2a4(gene name)|psi-mi:Slc2a4(display_short)|uniprotkb:Glut4(gene name synonym)	psi-mi:snd1_rat(display_long)|uniprotkb:p100 co-activator(gene name synonym)|uniprotkb:100 kDa coactivator(gene name synonym)|uniprotkb:p105 coactivator(gene name synonym)|uniprotkb:SND p102(gene name synonym)|uniprotkb:Snd1(gene name)|psi-mi:Snd1(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Foster et al. (2006)	pubmed:16396496|mint:MINT-5218203	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-921030	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2711|refseq:NP_036883.1|refseq:XP_006246658.1|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007611"(learning or memory)|go:"GO:0007614"(short-term memory)|go:"GO:0007616"(long-term memory)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010021"(amylopectin biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031550"(positive regulation of brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044381"(glucose import in response to insulin stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046323"(glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0098694"(regulation of synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0098793"(presynapse)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002441("Glucose transporter, type 4 (GLUT4)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-189200|ensembl:ENSRNOG00000017226(gene)|ensembl:ENSRNOT00000023256(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)	rgd:631340|refseq:NP_073185.2|ensembl:ENSRNOG00000031173(gene)|ensembl:ENSRNOT00000047698(transcript)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0003723"(RNA binding)|go:"GO:0004518"(nuclease activity)|go:"GO:0004519"(endonuclease activity)|go:"GO:0004521"(endoribonuclease activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006401"(RNA catabolic process)|go:"GO:0010564"(regulation of cell cycle process)|go:"GO:0010587"(miRNA catabolic process)|go:"GO:0016442"(RISC complex)|go:"GO:0031047"(gene silencing by RNA)|go:"GO:0042470"(melanosome)|go:"GO:0097433"(dense body)|go:"GO:1905172"(RISC complex binding)|interpro:IPR002071(Thermonuclease active site)|interpro:IPR002999(Tudor)|interpro:IPR016071("Staphylococcal nuclease (SNase-like), OB-fold")|interpro:IPR016685(RNA-induced silencing complex, nuclease component Tudor-SN)|interpro:IPR035437	-	-	-	caution:"The participant EBI-349571(P68370) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919386(Q7TP47) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920972(Q5XIP9) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-916419(P11980) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919578(Q8R491) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920554(Q5U3Z7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920647(Q5U2X8) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920585(Q7TP24) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-779677(P05426) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-915744(P02454) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|agonist:Insulin was shown to increase or decrease GLUT4 protein interactions in specific cases.|comment:"Insulin decreased GLUT4 interactions with the following proteins: Q9ER30 (Sarcosin), P09527 (Rab-7), O88960 (N-ethylmaleimide sensitive), P09456 (PKA I regulatory subunit), P27881 (Hexokinase type II), P07872 (Acyl-coenzyme A oxidase), Q6DGF1 (Isocitrate dehydrogenase), Q9EQX9 (Ubiquitin-conjugating), Q63446 (Polyubiquitin), P24268 (Cathepsin D), Q91XW0 (Heat shock protein 86), Q5FVH0 (unknown), P58405 (Striatin 3), Q62667 (Major vault protein), Q66H50 (unknown), Q09167 (splicing factor), Q9JHU5 (Arfaptin 1)."|comment:"Insulin increased GLUT4 interaction with the following proteins:Q9Z1P2 (R-actinin-1), P45592 (Cofilin), Q9QXQ0 (R-actinin-4), P26473 (ADP-ribosylation factor), P26437 (ADP-ribosylation factor),   Q7TNP1 (Basigin 2), Q6P6R2 (Dihydrolipoamide dehydrogenase),   P04797 (GAPDH), Q63081 (Protein disulfide isomerase), P29457 (47 kDa heat shock protein), Q9R1J8 (Leprecan), O88638 (Putative eps protein),   Q64375 (Synaptonemal complex)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:NDPK - Interactions involving proteins containing InterPro domain IPR001564, Nucleoside diphosphate kinase, core.	taxid:10116(rat-l6)|taxid:10116(Rattus norvegicus)	-	2006/02/15	2021/11/30	rogid:PbFY2lfrty8yw40Jq7ShR7xfuV410116	rogid:WR0TFGzKIw+y3hOMQuF8qOeIZmo10116	intact-crc:44F3A2176D02515F|rigid:9RVm0UBcqQF4k06RGKO89Bg16Q8	false	myc tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P19357	uniprotkb:Q6IN22	intact:EBI-915426|uniprotkb:P97900|ensembl:ENSRNOP00000023256	intact:EBI-918791|ensembl:ENSRNOP00000014178	psi-mi:glut4_rat(display_long)|uniprotkb:Glucose transporter type 4, insulin-responsive(gene name synonym)|uniprotkb:Slc2a4(gene name)|psi-mi:Slc2a4(display_short)|uniprotkb:Glut4(gene name synonym)	psi-mi:q6in22_rat(display_long)|uniprotkb:Ctsb(gene name)|psi-mi:Ctsb(display_short)|uniprotkb:Cathepsin B heavy chain(gene name synonym)|uniprotkb:Cathepsin B light chain(gene name synonym)|uniprotkb:rCG_52258(orf name)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Foster et al. (2006)	pubmed:16396496|mint:MINT-5218203	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-921030	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2711|refseq:NP_036883.1|refseq:XP_006246658.1|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007611"(learning or memory)|go:"GO:0007614"(short-term memory)|go:"GO:0007616"(long-term memory)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010021"(amylopectin biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031550"(positive regulation of brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044381"(glucose import in response to insulin stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046323"(glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0098694"(regulation of synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0098793"(presynapse)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002441("Glucose transporter, type 4 (GLUT4)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-189200|ensembl:ENSRNOG00000017226(gene)|ensembl:ENSRNOT00000023256(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)	rgd:621509|refseq:NP_072119.2|ensembl:ENSRNOG00000010331(gene)|ensembl:ENSRNOT00000014177(transcript)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0005518"(collagen binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005764"(lysosome)|go:"GO:0006590"(thyroid hormone generation)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0030574"(collagen catabolic process)|go:"GO:0030855"(epithelial cell differentiation)|go:"GO:0043394"(proteoglycan binding)|go:"GO:0046697"(decidualization)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050790"(regulation of catalytic activity)|go:"GO:0051603"(proteolysis involved in cellular protein catabolic process)|go:"GO:0097067"(cellular response to thyroid hormone stimulus)|interpro:IPR000169(Peptidase, cysteine peptidase active site)|interpro:IPR000668(Peptidase C1A, papain C-terminal)|interpro:IPR012599(Peptidase C1A, propeptide)|interpro:IPR025660|interpro:IPR025661|interpro:IPR038765	-	-	-	caution:"The participant EBI-349571(P68370) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919386(Q7TP47) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920972(Q5XIP9) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-916419(P11980) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919578(Q8R491) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920554(Q5U3Z7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920647(Q5U2X8) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920585(Q7TP24) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-779677(P05426) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-915744(P02454) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|agonist:Insulin was shown to increase or decrease GLUT4 protein interactions in specific cases.|comment:"Insulin decreased GLUT4 interactions with the following proteins: Q9ER30 (Sarcosin), P09527 (Rab-7), O88960 (N-ethylmaleimide sensitive), P09456 (PKA I regulatory subunit), P27881 (Hexokinase type II), P07872 (Acyl-coenzyme A oxidase), Q6DGF1 (Isocitrate dehydrogenase), Q9EQX9 (Ubiquitin-conjugating), Q63446 (Polyubiquitin), P24268 (Cathepsin D), Q91XW0 (Heat shock protein 86), Q5FVH0 (unknown), P58405 (Striatin 3), Q62667 (Major vault protein), Q66H50 (unknown), Q09167 (splicing factor), Q9JHU5 (Arfaptin 1)."|comment:"Insulin increased GLUT4 interaction with the following proteins:Q9Z1P2 (R-actinin-1), P45592 (Cofilin), Q9QXQ0 (R-actinin-4), P26473 (ADP-ribosylation factor), P26437 (ADP-ribosylation factor),   Q7TNP1 (Basigin 2), Q6P6R2 (Dihydrolipoamide dehydrogenase),   P04797 (GAPDH), Q63081 (Protein disulfide isomerase), P29457 (47 kDa heat shock protein), Q9R1J8 (Leprecan), O88638 (Putative eps protein),   Q64375 (Synaptonemal complex)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:NDPK - Interactions involving proteins containing InterPro domain IPR001564, Nucleoside diphosphate kinase, core.	taxid:10116(rat-l6)|taxid:10116(Rattus norvegicus)	-	2006/02/15	2021/11/30	rogid:PbFY2lfrty8yw40Jq7ShR7xfuV410116	rogid:T1Pjq4w6QZoj3ZmpYKakDiIZQAY10116	intact-crc:44F3A2176D02515F|rigid:9RVm0UBcqQF4k06RGKO89Bg16Q8	false	myc tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P19357	uniprotkb:Q6IMX8	intact:EBI-915426|uniprotkb:P97900|ensembl:ENSRNOP00000023256	intact:EBI-918781|ensembl:ENSRNOP00000013515	psi-mi:glut4_rat(display_long)|uniprotkb:Glucose transporter type 4, insulin-responsive(gene name synonym)|uniprotkb:Slc2a4(gene name)|psi-mi:Slc2a4(display_short)|uniprotkb:Glut4(gene name synonym)	psi-mi:q6imx8_rat(display_long)|uniprotkb:Acot2(gene name)|psi-mi:Acot2(display_short)|uniprotkb:rCG_20653(orf name)|uniprotkb:Mte1(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Foster et al. (2006)	pubmed:16396496|mint:MINT-5218203	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-921030	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2711|refseq:NP_036883.1|refseq:XP_006246658.1|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007611"(learning or memory)|go:"GO:0007614"(short-term memory)|go:"GO:0007616"(long-term memory)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010021"(amylopectin biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031550"(positive regulation of brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044381"(glucose import in response to insulin stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046323"(glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0098694"(regulation of synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0098793"(presynapse)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002441("Glucose transporter, type 4 (GLUT4)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-189200|ensembl:ENSRNOG00000017226(gene)|ensembl:ENSRNOT00000023256(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)	rgd:621055|refseq:NP_620262.2|ensembl:ENSRNOG00000010134(gene)|ensembl:ENSRNOT00000013515(transcript)|go:"GO:0006631"(fatty acid metabolic process)|go:"GO:0006637"(acyl-CoA metabolic process)|go:"GO:0016790"(thiolester hydrolase activity)|interpro:IPR006862(Acyl-CoA thioester hydrolase/bile acid-CoA amino acid N-acetyltransferase)|interpro:IPR014940(BAAT/Acyl-CoA thioester hydrolase C-terminal)|interpro:IPR016662(Acyl-CoA thioesterase, long chain)|interpro:IPR029058|interpro:IPR042490	-	-	-	caution:"The participant EBI-349571(P68370) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919386(Q7TP47) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920972(Q5XIP9) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-916419(P11980) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919578(Q8R491) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920554(Q5U3Z7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920647(Q5U2X8) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920585(Q7TP24) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-779677(P05426) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-915744(P02454) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|agonist:Insulin was shown to increase or decrease GLUT4 protein interactions in specific cases.|comment:"Insulin decreased GLUT4 interactions with the following proteins: Q9ER30 (Sarcosin), P09527 (Rab-7), O88960 (N-ethylmaleimide sensitive), P09456 (PKA I regulatory subunit), P27881 (Hexokinase type II), P07872 (Acyl-coenzyme A oxidase), Q6DGF1 (Isocitrate dehydrogenase), Q9EQX9 (Ubiquitin-conjugating), Q63446 (Polyubiquitin), P24268 (Cathepsin D), Q91XW0 (Heat shock protein 86), Q5FVH0 (unknown), P58405 (Striatin 3), Q62667 (Major vault protein), Q66H50 (unknown), Q09167 (splicing factor), Q9JHU5 (Arfaptin 1)."|comment:"Insulin increased GLUT4 interaction with the following proteins:Q9Z1P2 (R-actinin-1), P45592 (Cofilin), Q9QXQ0 (R-actinin-4), P26473 (ADP-ribosylation factor), P26437 (ADP-ribosylation factor),   Q7TNP1 (Basigin 2), Q6P6R2 (Dihydrolipoamide dehydrogenase),   P04797 (GAPDH), Q63081 (Protein disulfide isomerase), P29457 (47 kDa heat shock protein), Q9R1J8 (Leprecan), O88638 (Putative eps protein),   Q64375 (Synaptonemal complex)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:NDPK - Interactions involving proteins containing InterPro domain IPR001564, Nucleoside diphosphate kinase, core.	taxid:10116(rat-l6)|taxid:10116(Rattus norvegicus)	-	2006/02/15	2021/11/30	rogid:PbFY2lfrty8yw40Jq7ShR7xfuV410116	rogid:eUQYsHmZ8qgGMJqQJeoi9Yev57I10116	intact-crc:44F3A2176D02515F|rigid:9RVm0UBcqQF4k06RGKO89Bg16Q8	false	myc tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P19357	uniprotkb:P28073	intact:EBI-915426|uniprotkb:P97900|ensembl:ENSRNOP00000023256	intact:EBI-918772|uniprotkb:Q6IE68|uniprotkb:Q6PDW5|ensembl:ENSRNOP00000026507	psi-mi:glut4_rat(display_long)|uniprotkb:Glucose transporter type 4, insulin-responsive(gene name synonym)|uniprotkb:Slc2a4(gene name)|psi-mi:Slc2a4(display_short)|uniprotkb:Glut4(gene name synonym)	psi-mi:psb6_rat(display_long)|uniprotkb:Proteasome delta chain(gene name synonym)|uniprotkb:Macropain delta chain(gene name synonym)|uniprotkb:Multicatalytic endopeptidase complex delta chain(gene name synonym)|uniprotkb:Proteasome subunit Y(gene name synonym)|uniprotkb:Proteasome chain 5(gene name synonym)|uniprotkb:Psmb6(gene name)|psi-mi:Psmb6(display_short)|uniprotkb:Psmb6l(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Foster et al. (2006)	pubmed:16396496|mint:MINT-5218203	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-921030	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2711|refseq:NP_036883.1|refseq:XP_006246658.1|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007611"(learning or memory)|go:"GO:0007614"(short-term memory)|go:"GO:0007616"(long-term memory)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010021"(amylopectin biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031550"(positive regulation of brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044381"(glucose import in response to insulin stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046323"(glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0098694"(regulation of synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0098793"(presynapse)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002441("Glucose transporter, type 4 (GLUT4)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-189200|ensembl:ENSRNOG00000017226(gene)|ensembl:ENSRNOT00000023256(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)	rgd:61881|refseq:NP_476440.2|ensembl:ENSRNOG00000019551(gene)|ensembl:ENSRNOT00000026507(transcript)|go:"GO:0000502"(proteasome complex)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004298"(threonine-type endopeptidase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005839"(proteasome core complex)|go:"GO:0010499"(proteasomal ubiquitin-independent protein catabolic process)|go:"GO:0019774"(proteasome core complex, beta-subunit complex)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|interpro:IPR000243(Peptidase T1A, proteasome beta-subunit)|interpro:IPR001353(20S proteasome, A and B subunits)|interpro:IPR016050(Proteasome, beta-type subunit, conserved site)|interpro:IPR023333|interpro:IPR029055|interpro:IPR035140|rcsb pdb:6EPC|rcsb pdb:6EPD|rcsb pdb:6EPE|rcsb pdb:6EPF|rcsb pdb:6TU3|reactome:R-RNO-1169091|reactome:R-RNO-1234176|refseq:NP_001316812.1|reactome:R-RNO-1236978|reactome:R-RNO-174084|reactome:R-RNO-174154|reactome:R-RNO-174178|reactome:R-RNO-174184|reactome:R-RNO-187577|reactome:R-RNO-195253|reactome:R-RNO-2467813|reactome:R-RNO-349425|reactome:R-RNO-350562|reactome:R-RNO-382556|reactome:R-RNO-450408|reactome:R-RNO-4608870|reactome:R-RNO-4641257|reactome:R-RNO-4641258|reactome:R-RNO-5358346|reactome:R-RNO-5607761|reactome:R-RNO-5610780|reactome:R-RNO-5610785|reactome:R-RNO-5632684|reactome:R-RNO-5658442|reactome:R-RNO-5668541|reactome:R-RNO-5676590|reactome:R-RNO-5687128|reactome:R-RNO-5689603|reactome:R-RNO-5689880|reactome:R-RNO-68827|reactome:R-RNO-68949|reactome:R-RNO-69017|reactome:R-RNO-69481|reactome:R-RNO-69601|reactome:R-RNO-75815|reactome:R-RNO-8852276|reactome:R-RNO-8854050|reactome:R-RNO-8932339|reactome:R-RNO-8939236|reactome:R-RNO-8941858|reactome:R-RNO-8948751|reactome:R-RNO-8951664|reactome:R-RNO-983168	-	-	-	caution:"The participant EBI-349571(P68370) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919386(Q7TP47) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920972(Q5XIP9) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-916419(P11980) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919578(Q8R491) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920554(Q5U3Z7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920647(Q5U2X8) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920585(Q7TP24) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-779677(P05426) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-915744(P02454) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|agonist:Insulin was shown to increase or decrease GLUT4 protein interactions in specific cases.|comment:"Insulin decreased GLUT4 interactions with the following proteins: Q9ER30 (Sarcosin), P09527 (Rab-7), O88960 (N-ethylmaleimide sensitive), P09456 (PKA I regulatory subunit), P27881 (Hexokinase type II), P07872 (Acyl-coenzyme A oxidase), Q6DGF1 (Isocitrate dehydrogenase), Q9EQX9 (Ubiquitin-conjugating), Q63446 (Polyubiquitin), P24268 (Cathepsin D), Q91XW0 (Heat shock protein 86), Q5FVH0 (unknown), P58405 (Striatin 3), Q62667 (Major vault protein), Q66H50 (unknown), Q09167 (splicing factor), Q9JHU5 (Arfaptin 1)."|comment:"Insulin increased GLUT4 interaction with the following proteins:Q9Z1P2 (R-actinin-1), P45592 (Cofilin), Q9QXQ0 (R-actinin-4), P26473 (ADP-ribosylation factor), P26437 (ADP-ribosylation factor),   Q7TNP1 (Basigin 2), Q6P6R2 (Dihydrolipoamide dehydrogenase),   P04797 (GAPDH), Q63081 (Protein disulfide isomerase), P29457 (47 kDa heat shock protein), Q9R1J8 (Leprecan), O88638 (Putative eps protein),   Q64375 (Synaptonemal complex)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:NDPK - Interactions involving proteins containing InterPro domain IPR001564, Nucleoside diphosphate kinase, core.	taxid:10116(rat-l6)|taxid:10116(Rattus norvegicus)	-	2006/02/15	2021/11/30	rogid:PbFY2lfrty8yw40Jq7ShR7xfuV410116	rogid:OKL23OfU9U+QsP/nKMx9+zHxFRA10116	intact-crc:44F3A2176D02515F|rigid:9RVm0UBcqQF4k06RGKO89Bg16Q8	false	myc tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P19357	uniprotkb:Q6IE67	intact:EBI-915426|uniprotkb:P97900|ensembl:ENSRNOP00000023256	intact:EBI-918761	psi-mi:glut4_rat(display_long)|uniprotkb:Glucose transporter type 4, insulin-responsive(gene name synonym)|uniprotkb:Slc2a4(gene name)|psi-mi:Slc2a4(display_short)|uniprotkb:Glut4(gene name synonym)	psi-mi:q6ie67_rat(display_long)|uniprotkb:psma3l(gene name)|psi-mi:psma3l(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Foster et al. (2006)	pubmed:16396496|mint:MINT-5218203	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-921030	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2711|refseq:NP_036883.1|refseq:XP_006246658.1|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007611"(learning or memory)|go:"GO:0007614"(short-term memory)|go:"GO:0007616"(long-term memory)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010021"(amylopectin biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031550"(positive regulation of brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044381"(glucose import in response to insulin stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046323"(glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0098694"(regulation of synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0098793"(presynapse)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002441("Glucose transporter, type 4 (GLUT4)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-189200|ensembl:ENSRNOG00000017226(gene)|ensembl:ENSRNOT00000023256(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)	interpro:IPR000426(Proteasome alpha-subunit, conserved site)|interpro:IPR023332|interpro:IPR001353(20S proteasome, A and B subunits)|interpro:IPR029055|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0019773"(proteasome core complex, alpha-subunit complex)|interpro:IPR037555	-	-	-	caution:"The participant EBI-349571(P68370) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919386(Q7TP47) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920972(Q5XIP9) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-916419(P11980) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919578(Q8R491) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920554(Q5U3Z7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920647(Q5U2X8) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920585(Q7TP24) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-779677(P05426) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-915744(P02454) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|agonist:Insulin was shown to increase or decrease GLUT4 protein interactions in specific cases.|comment:"Insulin decreased GLUT4 interactions with the following proteins: Q9ER30 (Sarcosin), P09527 (Rab-7), O88960 (N-ethylmaleimide sensitive), P09456 (PKA I regulatory subunit), P27881 (Hexokinase type II), P07872 (Acyl-coenzyme A oxidase), Q6DGF1 (Isocitrate dehydrogenase), Q9EQX9 (Ubiquitin-conjugating), Q63446 (Polyubiquitin), P24268 (Cathepsin D), Q91XW0 (Heat shock protein 86), Q5FVH0 (unknown), P58405 (Striatin 3), Q62667 (Major vault protein), Q66H50 (unknown), Q09167 (splicing factor), Q9JHU5 (Arfaptin 1)."|comment:"Insulin increased GLUT4 interaction with the following proteins:Q9Z1P2 (R-actinin-1), P45592 (Cofilin), Q9QXQ0 (R-actinin-4), P26473 (ADP-ribosylation factor), P26437 (ADP-ribosylation factor),   Q7TNP1 (Basigin 2), Q6P6R2 (Dihydrolipoamide dehydrogenase),   P04797 (GAPDH), Q63081 (Protein disulfide isomerase), P29457 (47 kDa heat shock protein), Q9R1J8 (Leprecan), O88638 (Putative eps protein),   Q64375 (Synaptonemal complex)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:NDPK - Interactions involving proteins containing InterPro domain IPR001564, Nucleoside diphosphate kinase, core.	taxid:10116(rat-l6)|taxid:10116(Rattus norvegicus)	-	2006/02/15	2021/11/30	rogid:PbFY2lfrty8yw40Jq7ShR7xfuV410116	rogid:XZnxnhDGplZn0sTZraNJtTe4UZo10116	intact-crc:44F3A2176D02515F|rigid:9RVm0UBcqQF4k06RGKO89Bg16Q8	false	myc tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P19357	uniprotkb:Q6GQP4	intact:EBI-915426|uniprotkb:P97900|ensembl:ENSRNOP00000023256	intact:EBI-918753|uniprotkb:Q9JK74	psi-mi:glut4_rat(display_long)|uniprotkb:Glucose transporter type 4, insulin-responsive(gene name synonym)|uniprotkb:Slc2a4(gene name)|psi-mi:Slc2a4(display_short)|uniprotkb:Glut4(gene name synonym)	psi-mi:rab31_rat(display_long)|uniprotkb:GTP-binding protein Rab0(gene name synonym)|uniprotkb:Rab31(gene name)|psi-mi:Rab31(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Foster et al. (2006)	pubmed:16396496|mint:MINT-5218203	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-921030	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2711|refseq:NP_036883.1|refseq:XP_006246658.1|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007611"(learning or memory)|go:"GO:0007614"(short-term memory)|go:"GO:0007616"(long-term memory)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010021"(amylopectin biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031550"(positive regulation of brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044381"(glucose import in response to insulin stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046323"(glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0098694"(regulation of synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0098793"(presynapse)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002441("Glucose transporter, type 4 (GLUT4)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-189200|ensembl:ENSRNOG00000017226(gene)|ensembl:ENSRNOT00000023256(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)	rgd:628598|refseq:NP_659562.2|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR001806(Ras GTPase)|go:"GO:0001891"(phagocytic cup)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005769"(early endosome)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0012505"(endomembrane system)|go:"GO:0019003"(GDP binding)|go:"GO:0031623"(receptor internalization)|go:"GO:0032588"(trans-Golgi network membrane)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0036186"(early phagosome membrane)|go:"GO:0043001"(Golgi to plasma membrane protein transport)|go:"GO:0045055"(regulated exocytosis)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0048193"(Golgi vesicle transport)|go:"GO:0060100"(positive regulation of phagocytosis, engulfment)|go:"GO:0090382"(phagosome maturation)|interpro:IPR027417|reactome:R-RNO-6798695|reactome:R-RNO-8873719|reactome:R-RNO-8876198	-	-	-	caution:"The participant EBI-349571(P68370) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919386(Q7TP47) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920972(Q5XIP9) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-916419(P11980) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919578(Q8R491) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920554(Q5U3Z7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920647(Q5U2X8) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920585(Q7TP24) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-779677(P05426) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-915744(P02454) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|agonist:Insulin was shown to increase or decrease GLUT4 protein interactions in specific cases.|comment:"Insulin decreased GLUT4 interactions with the following proteins: Q9ER30 (Sarcosin), P09527 (Rab-7), O88960 (N-ethylmaleimide sensitive), P09456 (PKA I regulatory subunit), P27881 (Hexokinase type II), P07872 (Acyl-coenzyme A oxidase), Q6DGF1 (Isocitrate dehydrogenase), Q9EQX9 (Ubiquitin-conjugating), Q63446 (Polyubiquitin), P24268 (Cathepsin D), Q91XW0 (Heat shock protein 86), Q5FVH0 (unknown), P58405 (Striatin 3), Q62667 (Major vault protein), Q66H50 (unknown), Q09167 (splicing factor), Q9JHU5 (Arfaptin 1)."|comment:"Insulin increased GLUT4 interaction with the following proteins:Q9Z1P2 (R-actinin-1), P45592 (Cofilin), Q9QXQ0 (R-actinin-4), P26473 (ADP-ribosylation factor), P26437 (ADP-ribosylation factor),   Q7TNP1 (Basigin 2), Q6P6R2 (Dihydrolipoamide dehydrogenase),   P04797 (GAPDH), Q63081 (Protein disulfide isomerase), P29457 (47 kDa heat shock protein), Q9R1J8 (Leprecan), O88638 (Putative eps protein),   Q64375 (Synaptonemal complex)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:NDPK - Interactions involving proteins containing InterPro domain IPR001564, Nucleoside diphosphate kinase, core.	taxid:10116(rat-l6)|taxid:10116(Rattus norvegicus)	-	2006/02/15	2021/11/30	rogid:PbFY2lfrty8yw40Jq7ShR7xfuV410116	rogid:fhyJVmJqR0LoLxL7Y8BvyGpEymA10116	intact-crc:44F3A2176D02515F|rigid:9RVm0UBcqQF4k06RGKO89Bg16Q8	false	myc tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P19357	uniprotkb:Q9JLJ3	intact:EBI-915426|uniprotkb:P97900|ensembl:ENSRNOP00000023256	intact:EBI-918743|uniprotkb:Q6GMM4	psi-mi:glut4_rat(display_long)|uniprotkb:Glucose transporter type 4, insulin-responsive(gene name synonym)|uniprotkb:Slc2a4(gene name)|psi-mi:Slc2a4(display_short)|uniprotkb:Glut4(gene name synonym)	psi-mi:al9a1_rat(display_long)|uniprotkb:Aldehyde dehydrogenase family 9 member A1(gene name synonym)|uniprotkb:Aldh9a1(gene name)|psi-mi:Aldh9a1(display_short)|uniprotkb:Gamma-aminobutyraldehyde dehydrogenase(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Foster et al. (2006)	pubmed:16396496|mint:MINT-5218203	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-921030	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2711|refseq:NP_036883.1|refseq:XP_006246658.1|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007611"(learning or memory)|go:"GO:0007614"(short-term memory)|go:"GO:0007616"(long-term memory)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010021"(amylopectin biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031550"(positive regulation of brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044381"(glucose import in response to insulin stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046323"(glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0098694"(regulation of synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0098793"(presynapse)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002441("Glucose transporter, type 4 (GLUT4)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-189200|ensembl:ENSRNOG00000017226(gene)|ensembl:ENSRNOT00000023256(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)	rgd:68409|refseq:NP_071609.2|interpro:IPR016161(Aldehyde/histidinol dehydrogenase)|interpro:IPR016160(Aldehyde dehydrogenase, conserved site)|interpro:IPR016162(Aldehyde dehydrogenase, N-terminal)|interpro:IPR015590(Aldehyde dehydrogenase)|interpro:IPR029510|go:"GO:0001822"(kidney development)|go:"GO:0001889"(liver development)|go:"GO:0004029"("aldehyde dehydrogenase (NAD+) activity")|go:"GO:0005829"(cytosol)|go:"GO:0006081"(cellular aldehyde metabolic process)|go:"GO:0009437"(carnitine metabolic process)|go:"GO:0016620"(oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor)|go:"GO:0019145"(aminobutyraldehyde dehydrogenase activity)|go:"GO:0033737"(1-pyrroline dehydrogenase activity)|go:"GO:0042136"(neurotransmitter biosynthetic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0043176"(amine binding)|go:"GO:0043878"("glyceraldehyde-3-phosphate dehydrogenase (NAD+) (non-phosphorylating) activity")|go:"GO:0045329"(carnitine biosynthetic process)|go:"GO:0047105"(4-trimethylammoniobutyraldehyde dehydrogenase activity)|go:"GO:0051287"(NAD binding)|go:"GO:0051289"(protein homotetramerization)|interpro:IPR016163(Aldehyde dehydrogenase, C-terminal)|reactome:R-RNO-71262	-	-	-	caution:"The participant EBI-349571(P68370) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919386(Q7TP47) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920972(Q5XIP9) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-916419(P11980) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919578(Q8R491) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920554(Q5U3Z7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920647(Q5U2X8) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920585(Q7TP24) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-779677(P05426) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-915744(P02454) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|agonist:Insulin was shown to increase or decrease GLUT4 protein interactions in specific cases.|comment:"Insulin decreased GLUT4 interactions with the following proteins: Q9ER30 (Sarcosin), P09527 (Rab-7), O88960 (N-ethylmaleimide sensitive), P09456 (PKA I regulatory subunit), P27881 (Hexokinase type II), P07872 (Acyl-coenzyme A oxidase), Q6DGF1 (Isocitrate dehydrogenase), Q9EQX9 (Ubiquitin-conjugating), Q63446 (Polyubiquitin), P24268 (Cathepsin D), Q91XW0 (Heat shock protein 86), Q5FVH0 (unknown), P58405 (Striatin 3), Q62667 (Major vault protein), Q66H50 (unknown), Q09167 (splicing factor), Q9JHU5 (Arfaptin 1)."|comment:"Insulin increased GLUT4 interaction with the following proteins:Q9Z1P2 (R-actinin-1), P45592 (Cofilin), Q9QXQ0 (R-actinin-4), P26473 (ADP-ribosylation factor), P26437 (ADP-ribosylation factor),   Q7TNP1 (Basigin 2), Q6P6R2 (Dihydrolipoamide dehydrogenase),   P04797 (GAPDH), Q63081 (Protein disulfide isomerase), P29457 (47 kDa heat shock protein), Q9R1J8 (Leprecan), O88638 (Putative eps protein),   Q64375 (Synaptonemal complex)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:NDPK - Interactions involving proteins containing InterPro domain IPR001564, Nucleoside diphosphate kinase, core.	taxid:10116(rat-l6)|taxid:10116(Rattus norvegicus)	-	2006/02/15	2021/11/30	rogid:PbFY2lfrty8yw40Jq7ShR7xfuV410116	rogid:+ZFsJgp3DrpUgc7w6vKsQyeDMPk10116	intact-crc:44F3A2176D02515F|rigid:9RVm0UBcqQF4k06RGKO89Bg16Q8	false	myc tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P19357	uniprotkb:Q64591	intact:EBI-915426|uniprotkb:P97900|ensembl:ENSRNOP00000023256	intact:EBI-918734|uniprotkb:Q6PCV4	psi-mi:glut4_rat(display_long)|uniprotkb:Glucose transporter type 4, insulin-responsive(gene name synonym)|uniprotkb:Slc2a4(gene name)|psi-mi:Slc2a4(display_short)|uniprotkb:Glut4(gene name synonym)	psi-mi:decr_rat(display_long)|uniprotkb:2,4-dienoyl-CoA reductase [NADPH](gene name synonym)|uniprotkb:Decr1(gene name)|psi-mi:Decr1(display_short)|uniprotkb:Decr(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Foster et al. (2006)	pubmed:16396496|mint:MINT-5218203	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-921030	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2711|refseq:NP_036883.1|refseq:XP_006246658.1|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007611"(learning or memory)|go:"GO:0007614"(short-term memory)|go:"GO:0007616"(long-term memory)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010021"(amylopectin biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031550"(positive regulation of brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044381"(glucose import in response to insulin stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046323"(glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0098694"(regulation of synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0098793"(presynapse)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002441("Glucose transporter, type 4 (GLUT4)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-189200|ensembl:ENSRNOG00000017226(gene)|ensembl:ENSRNOT00000023256(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)	rgd:70999|refseq:NP_476545.2|interpro:IPR002347(Glucose/ribitol dehydrogenase)|go:"GO:0005739"(mitochondrion)|go:"GO:0006635"(fatty acid beta-oxidation)|go:"GO:0008670"("2,4-dienoyl-CoA reductase (NADPH) activity")|go:"GO:0042802"(identical protein binding)|go:"GO:0070402"(NADPH binding)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:1902494"(catalytic complex)|interpro:IPR036291|reactome:R-RNO-77288	-	-	-	caution:"The participant EBI-349571(P68370) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919386(Q7TP47) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920972(Q5XIP9) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-916419(P11980) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919578(Q8R491) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920554(Q5U3Z7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920647(Q5U2X8) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920585(Q7TP24) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-779677(P05426) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-915744(P02454) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|agonist:Insulin was shown to increase or decrease GLUT4 protein interactions in specific cases.|comment:"Insulin decreased GLUT4 interactions with the following proteins: Q9ER30 (Sarcosin), P09527 (Rab-7), O88960 (N-ethylmaleimide sensitive), P09456 (PKA I regulatory subunit), P27881 (Hexokinase type II), P07872 (Acyl-coenzyme A oxidase), Q6DGF1 (Isocitrate dehydrogenase), Q9EQX9 (Ubiquitin-conjugating), Q63446 (Polyubiquitin), P24268 (Cathepsin D), Q91XW0 (Heat shock protein 86), Q5FVH0 (unknown), P58405 (Striatin 3), Q62667 (Major vault protein), Q66H50 (unknown), Q09167 (splicing factor), Q9JHU5 (Arfaptin 1)."|comment:"Insulin increased GLUT4 interaction with the following proteins:Q9Z1P2 (R-actinin-1), P45592 (Cofilin), Q9QXQ0 (R-actinin-4), P26473 (ADP-ribosylation factor), P26437 (ADP-ribosylation factor),   Q7TNP1 (Basigin 2), Q6P6R2 (Dihydrolipoamide dehydrogenase),   P04797 (GAPDH), Q63081 (Protein disulfide isomerase), P29457 (47 kDa heat shock protein), Q9R1J8 (Leprecan), O88638 (Putative eps protein),   Q64375 (Synaptonemal complex)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:NDPK - Interactions involving proteins containing InterPro domain IPR001564, Nucleoside diphosphate kinase, core.	taxid:10116(rat-l6)|taxid:10116(Rattus norvegicus)	-	2006/02/15	2021/11/30	rogid:PbFY2lfrty8yw40Jq7ShR7xfuV410116	rogid:vOrbpLOggYE9K8Bg4/FGMKzVE2c10116	intact-crc:44F3A2176D02515F|rigid:9RVm0UBcqQF4k06RGKO89Bg16Q8	false	myc tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P19357	uniprotkb:Q64560	intact:EBI-915426|uniprotkb:P97900|ensembl:ENSRNOP00000023256	intact:EBI-918726|ensembl:ENSRNOP00000015393|ensembl:ENSRNOP00000074045|ensembl:ENSRNOP00000074556	psi-mi:glut4_rat(display_long)|uniprotkb:Glucose transporter type 4, insulin-responsive(gene name synonym)|uniprotkb:Slc2a4(gene name)|psi-mi:Slc2a4(display_short)|uniprotkb:Glut4(gene name synonym)	psi-mi:tpp2_rat(display_long)|uniprotkb:Tripeptidyl-peptidase II(gene name synonym)|uniprotkb:Tripeptidyl aminopeptidase(gene name synonym)|uniprotkb:Tpp2(gene name)|psi-mi:Tpp2(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Foster et al. (2006)	pubmed:16396496|mint:MINT-5218203	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-921030	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2711|refseq:NP_036883.1|refseq:XP_006246658.1|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007611"(learning or memory)|go:"GO:0007614"(short-term memory)|go:"GO:0007616"(long-term memory)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010021"(amylopectin biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031550"(positive regulation of brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044381"(glucose import in response to insulin stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046323"(glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0098694"(regulation of synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0098793"(presynapse)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002441("Glucose transporter, type 4 (GLUT4)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-189200|ensembl:ENSRNOG00000017226(gene)|ensembl:ENSRNOT00000023256(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)	rgd:621584|refseq:NP_112399.1|ensembl:ENSRNOG00000011194(gene)|ensembl:ENSRNOT00000015393(transcript)|ensembl:ENSRNOT00000078220(transcript)|ensembl:ENSRNOT00000085267(transcript)|go:"GO:0004177"(aminopeptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005829"(cytosol)|go:"GO:0006508"(proteolysis)|go:"GO:0008240"(tripeptidyl-peptidase activity)|go:"GO:0016604"(nuclear body)|go:"GO:0042277"(peptide binding)|go:"GO:0042802"(identical protein binding)|interpro:IPR000209(Peptidase S8 and S53, subtilisin, kexin, sedolisin)|interpro:IPR015500(Peptidase S8, subtilisin-related)|interpro:IPR022229|interpro:IPR022398|interpro:IPR023828|interpro:IPR034051|interpro:IPR036852|reactome:R-RNO-983168	-	-	-	caution:"The participant EBI-349571(P68370) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919386(Q7TP47) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920972(Q5XIP9) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-916419(P11980) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919578(Q8R491) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920554(Q5U3Z7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920647(Q5U2X8) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920585(Q7TP24) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-779677(P05426) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-915744(P02454) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|agonist:Insulin was shown to increase or decrease GLUT4 protein interactions in specific cases.|comment:"Insulin decreased GLUT4 interactions with the following proteins: Q9ER30 (Sarcosin), P09527 (Rab-7), O88960 (N-ethylmaleimide sensitive), P09456 (PKA I regulatory subunit), P27881 (Hexokinase type II), P07872 (Acyl-coenzyme A oxidase), Q6DGF1 (Isocitrate dehydrogenase), Q9EQX9 (Ubiquitin-conjugating), Q63446 (Polyubiquitin), P24268 (Cathepsin D), Q91XW0 (Heat shock protein 86), Q5FVH0 (unknown), P58405 (Striatin 3), Q62667 (Major vault protein), Q66H50 (unknown), Q09167 (splicing factor), Q9JHU5 (Arfaptin 1)."|comment:"Insulin increased GLUT4 interaction with the following proteins:Q9Z1P2 (R-actinin-1), P45592 (Cofilin), Q9QXQ0 (R-actinin-4), P26473 (ADP-ribosylation factor), P26437 (ADP-ribosylation factor),   Q7TNP1 (Basigin 2), Q6P6R2 (Dihydrolipoamide dehydrogenase),   P04797 (GAPDH), Q63081 (Protein disulfide isomerase), P29457 (47 kDa heat shock protein), Q9R1J8 (Leprecan), O88638 (Putative eps protein),   Q64375 (Synaptonemal complex)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:NDPK - Interactions involving proteins containing InterPro domain IPR001564, Nucleoside diphosphate kinase, core.	taxid:10116(rat-l6)|taxid:10116(Rattus norvegicus)	-	2006/02/15	2021/11/30	rogid:PbFY2lfrty8yw40Jq7ShR7xfuV410116	rogid:MT2eGnpwddgDY/L2BzQL52FO7AM10116	intact-crc:44F3A2176D02515F|rigid:9RVm0UBcqQF4k06RGKO89Bg16Q8	false	myc tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P19357	uniprotkb:Q64537	intact:EBI-915426|uniprotkb:P97900|ensembl:ENSRNOP00000023256	intact:EBI-918712|uniprotkb:P97572|uniprotkb:Q4V795	psi-mi:glut4_rat(display_long)|uniprotkb:Glucose transporter type 4, insulin-responsive(gene name synonym)|uniprotkb:Slc2a4(gene name)|psi-mi:Slc2a4(display_short)|uniprotkb:Glut4(gene name synonym)	psi-mi:cpns1_rat(display_long)|uniprotkb:Calcium-dependent protease small subunit 1(gene name synonym)|uniprotkb:Calcium-dependent protease small subunit(gene name synonym)|uniprotkb:Calpain regulatory subunit(gene name synonym)|uniprotkb:Calcium-activated neutral proteinase small subunit(gene name synonym)|uniprotkb:Capns1(gene name)|psi-mi:Capns1(display_short)|uniprotkb:Capn4(gene name synonym)|uniprotkb:Css1(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Foster et al. (2006)	pubmed:16396496|mint:MINT-5218203	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-921030	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2711|refseq:NP_036883.1|refseq:XP_006246658.1|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007611"(learning or memory)|go:"GO:0007614"(short-term memory)|go:"GO:0007616"(long-term memory)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010021"(amylopectin biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031550"(positive regulation of brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044381"(glucose import in response to insulin stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046323"(glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0098694"(regulation of synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0098793"(presynapse)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002441("Glucose transporter, type 4 (GLUT4)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-189200|ensembl:ENSRNOG00000017226(gene)|ensembl:ENSRNOT00000023256(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)	rgd:2270|refseq:NP_058814.1|refseq:XP_017445520.1|dip:DIP-6140N|reactome:R-RNO-1474228|go:"GO:0004198"(calcium-dependent cysteine-type endopeptidase activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006508"(proteolysis)|go:"GO:0016020"(membrane)|go:"GO:0044877"(protein-containing complex binding)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR011992(EF-Hand type)|interpro:IPR018247|interpro:IPR029642|rcsb pdb:1AJ5|rcsb pdb:1DF0|rcsb pdb:1DVI|rcsb pdb:1NP8|rcsb pdb:1QXP|rcsb pdb:1U5I|rcsb pdb:3BOW|rcsb pdb:3DF0	-	-	-	caution:"The participant EBI-349571(P68370) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919386(Q7TP47) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920972(Q5XIP9) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-916419(P11980) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919578(Q8R491) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920554(Q5U3Z7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920647(Q5U2X8) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920585(Q7TP24) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-779677(P05426) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-915744(P02454) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|agonist:Insulin was shown to increase or decrease GLUT4 protein interactions in specific cases.|comment:"Insulin decreased GLUT4 interactions with the following proteins: Q9ER30 (Sarcosin), P09527 (Rab-7), O88960 (N-ethylmaleimide sensitive), P09456 (PKA I regulatory subunit), P27881 (Hexokinase type II), P07872 (Acyl-coenzyme A oxidase), Q6DGF1 (Isocitrate dehydrogenase), Q9EQX9 (Ubiquitin-conjugating), Q63446 (Polyubiquitin), P24268 (Cathepsin D), Q91XW0 (Heat shock protein 86), Q5FVH0 (unknown), P58405 (Striatin 3), Q62667 (Major vault protein), Q66H50 (unknown), Q09167 (splicing factor), Q9JHU5 (Arfaptin 1)."|comment:"Insulin increased GLUT4 interaction with the following proteins:Q9Z1P2 (R-actinin-1), P45592 (Cofilin), Q9QXQ0 (R-actinin-4), P26473 (ADP-ribosylation factor), P26437 (ADP-ribosylation factor),   Q7TNP1 (Basigin 2), Q6P6R2 (Dihydrolipoamide dehydrogenase),   P04797 (GAPDH), Q63081 (Protein disulfide isomerase), P29457 (47 kDa heat shock protein), Q9R1J8 (Leprecan), O88638 (Putative eps protein),   Q64375 (Synaptonemal complex)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:NDPK - Interactions involving proteins containing InterPro domain IPR001564, Nucleoside diphosphate kinase, core.	taxid:10116(rat-l6)|taxid:10116(Rattus norvegicus)	-	2006/02/15	2021/11/30	rogid:PbFY2lfrty8yw40Jq7ShR7xfuV410116	rogid:+XfXCHyp2hPFnx9wiagwOOj38NI10116	intact-crc:44F3A2176D02515F|rigid:9RVm0UBcqQF4k06RGKO89Bg16Q8	false	myc tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P19357	uniprotkb:Q64536	intact:EBI-915426|uniprotkb:P97900|ensembl:ENSRNOP00000023256	intact:EBI-918705	psi-mi:glut4_rat(display_long)|uniprotkb:Glucose transporter type 4, insulin-responsive(gene name synonym)|uniprotkb:Slc2a4(gene name)|psi-mi:Slc2a4(display_short)|uniprotkb:Glut4(gene name synonym)	psi-mi:pdk2_rat(display_long)|uniprotkb:Pyruvate dehydrogenase kinase isoform 2(gene name synonym)|uniprotkb:PDK P45(gene name synonym)|uniprotkb:Pdk2(gene name)|psi-mi:Pdk2(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Foster et al. (2006)	pubmed:16396496|mint:MINT-5218203	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-921030	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2711|refseq:NP_036883.1|refseq:XP_006246658.1|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007611"(learning or memory)|go:"GO:0007614"(short-term memory)|go:"GO:0007616"(long-term memory)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010021"(amylopectin biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031550"(positive regulation of brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044381"(glucose import in response to insulin stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046323"(glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0098694"(regulation of synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0098793"(presynapse)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002441("Glucose transporter, type 4 (GLUT4)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-189200|ensembl:ENSRNOG00000017226(gene)|ensembl:ENSRNOT00000023256(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)	rgd:69428|refseq:NP_110499.1|interpro:IPR003594(ATP-binding region, ATPase-like)|interpro:IPR018955|interpro:IPR005467(Signal transduction histidine kinase, core)|rcsb pdb:1JM6|rcsb pdb:3CRK|rcsb pdb:3CRL|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004740"("pyruvate dehydrogenase (acetyl-transferring) kinase activity")|go:"GO:0005524"(ATP binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005967"(mitochondrial pyruvate dehydrogenase complex)|go:"GO:0006006"(glucose metabolic process)|go:"GO:0006111"(regulation of gluconeogenesis)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006885"(regulation of pH)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0010510"(regulation of acetyl-CoA biosynthetic process from pyruvate)|go:"GO:0010565"(regulation of cellular ketone metabolic process)|go:"GO:0010906"(regulation of glucose metabolic process)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0031670"(cellular response to nutrient)|go:"GO:0034614"(cellular response to reactive oxygen species)|interpro:IPR039028|interpro:IPR036784|interpro:IPR036890|reactome:R-RNO-204174|reactome:R-RNO-5362517|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045254"(pyruvate dehydrogenase complex)|go:"GO:0050848"(regulation of calcium-mediated signaling)|go:"GO:0072332"(intrinsic apoptotic signaling pathway by p53 class mediator)	-	-	-	caution:"The participant EBI-349571(P68370) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919386(Q7TP47) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920972(Q5XIP9) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-916419(P11980) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919578(Q8R491) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920554(Q5U3Z7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920647(Q5U2X8) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920585(Q7TP24) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-779677(P05426) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-915744(P02454) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|agonist:Insulin was shown to increase or decrease GLUT4 protein interactions in specific cases.|comment:"Insulin decreased GLUT4 interactions with the following proteins: Q9ER30 (Sarcosin), P09527 (Rab-7), O88960 (N-ethylmaleimide sensitive), P09456 (PKA I regulatory subunit), P27881 (Hexokinase type II), P07872 (Acyl-coenzyme A oxidase), Q6DGF1 (Isocitrate dehydrogenase), Q9EQX9 (Ubiquitin-conjugating), Q63446 (Polyubiquitin), P24268 (Cathepsin D), Q91XW0 (Heat shock protein 86), Q5FVH0 (unknown), P58405 (Striatin 3), Q62667 (Major vault protein), Q66H50 (unknown), Q09167 (splicing factor), Q9JHU5 (Arfaptin 1)."|comment:"Insulin increased GLUT4 interaction with the following proteins:Q9Z1P2 (R-actinin-1), P45592 (Cofilin), Q9QXQ0 (R-actinin-4), P26473 (ADP-ribosylation factor), P26437 (ADP-ribosylation factor),   Q7TNP1 (Basigin 2), Q6P6R2 (Dihydrolipoamide dehydrogenase),   P04797 (GAPDH), Q63081 (Protein disulfide isomerase), P29457 (47 kDa heat shock protein), Q9R1J8 (Leprecan), O88638 (Putative eps protein),   Q64375 (Synaptonemal complex)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:NDPK - Interactions involving proteins containing InterPro domain IPR001564, Nucleoside diphosphate kinase, core.	taxid:10116(rat-l6)|taxid:10116(Rattus norvegicus)	-	2006/02/15	2021/11/30	rogid:PbFY2lfrty8yw40Jq7ShR7xfuV410116	rogid:y6gIaggQKGT+BXKdFxd13dPHg/010116	intact-crc:44F3A2176D02515F|rigid:9RVm0UBcqQF4k06RGKO89Bg16Q8	false	myc tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P19357	uniprotkb:Q64375	intact:EBI-915426|uniprotkb:P97900|ensembl:ENSRNOP00000023256	intact:EBI-918700|uniprotkb:A0A096MJK4|ensembl:ENSRNOP00000068162	psi-mi:glut4_rat(display_long)|uniprotkb:Glucose transporter type 4, insulin-responsive(gene name synonym)|uniprotkb:Slc2a4(gene name)|psi-mi:Slc2a4(display_short)|uniprotkb:Glut4(gene name synonym)	psi-mi:sc65_rat(display_long)|uniprotkb:Synaptonemal complex protein SC65(gene name synonym)|uniprotkb:P3h4(gene name)|psi-mi:P3h4(display_short)|uniprotkb:Leprecan-like protein 4(gene name synonym)|uniprotkb:Leprel4(gene name synonym)|uniprotkb:Prolyl 3-hydroxylase family member 4(gene name synonym)|uniprotkb:Sc65(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Foster et al. (2006)	pubmed:16396496|mint:MINT-5218203	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-921030	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2711|refseq:NP_036883.1|refseq:XP_006246658.1|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007611"(learning or memory)|go:"GO:0007614"(short-term memory)|go:"GO:0007616"(long-term memory)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010021"(amylopectin biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031550"(positive regulation of brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044381"(glucose import in response to insulin stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046323"(glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0098694"(regulation of synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0098793"(presynapse)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002441("Glucose transporter, type 4 (GLUT4)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-189200|ensembl:ENSRNOG00000017226(gene)|ensembl:ENSRNOT00000023256(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)	rgd:620767|refseq:NP_067592.2|ensembl:ENSRNOG00000015787(gene)|ensembl:ENSRNOT00000076585(transcript)|go:"GO:0000795"(synaptonemal complex)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0017185"(peptidyl-lysine hydroxylation)|go:"GO:0030199"(collagen fibril organization)|go:"GO:0032964"(collagen biosynthetic process)|go:"GO:0046849"(bone remodeling)|go:"GO:1902494"(catalytic complex)|interpro:IPR033213	-	-	-	caution:"The participant EBI-349571(P68370) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919386(Q7TP47) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920972(Q5XIP9) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-916419(P11980) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919578(Q8R491) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920554(Q5U3Z7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920647(Q5U2X8) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920585(Q7TP24) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-779677(P05426) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-915744(P02454) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|agonist:Insulin was shown to increase or decrease GLUT4 protein interactions in specific cases.|comment:"Insulin decreased GLUT4 interactions with the following proteins: Q9ER30 (Sarcosin), P09527 (Rab-7), O88960 (N-ethylmaleimide sensitive), P09456 (PKA I regulatory subunit), P27881 (Hexokinase type II), P07872 (Acyl-coenzyme A oxidase), Q6DGF1 (Isocitrate dehydrogenase), Q9EQX9 (Ubiquitin-conjugating), Q63446 (Polyubiquitin), P24268 (Cathepsin D), Q91XW0 (Heat shock protein 86), Q5FVH0 (unknown), P58405 (Striatin 3), Q62667 (Major vault protein), Q66H50 (unknown), Q09167 (splicing factor), Q9JHU5 (Arfaptin 1)."|comment:"Insulin increased GLUT4 interaction with the following proteins:Q9Z1P2 (R-actinin-1), P45592 (Cofilin), Q9QXQ0 (R-actinin-4), P26473 (ADP-ribosylation factor), P26437 (ADP-ribosylation factor),   Q7TNP1 (Basigin 2), Q6P6R2 (Dihydrolipoamide dehydrogenase),   P04797 (GAPDH), Q63081 (Protein disulfide isomerase), P29457 (47 kDa heat shock protein), Q9R1J8 (Leprecan), O88638 (Putative eps protein),   Q64375 (Synaptonemal complex)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:NDPK - Interactions involving proteins containing InterPro domain IPR001564, Nucleoside diphosphate kinase, core.	taxid:10116(rat-l6)|taxid:10116(Rattus norvegicus)	-	2006/02/15	2021/11/30	rogid:PbFY2lfrty8yw40Jq7ShR7xfuV410116	rogid:VxHf0xvvGZz33iXpCKLvszDA96o10116	intact-crc:44F3A2176D02515F|rigid:9RVm0UBcqQF4k06RGKO89Bg16Q8	false	myc tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P19357	uniprotkb:Q64232	intact:EBI-915426|uniprotkb:P97900|ensembl:ENSRNOP00000023256	intact:EBI-918695|ensembl:ENSRNOP00000035416	psi-mi:glut4_rat(display_long)|uniprotkb:Glucose transporter type 4, insulin-responsive(gene name synonym)|uniprotkb:Slc2a4(gene name)|psi-mi:Slc2a4(display_short)|uniprotkb:Glut4(gene name synonym)	psi-mi:tecr_rat(display_long)|uniprotkb:Tecr(gene name)|psi-mi:Tecr(display_short)|uniprotkb:Gpsn2(gene name synonym)|uniprotkb:Synaptic glycoprotein SC2(gene name synonym)|uniprotkb:Trans-2,3-enoyl-CoA reductase(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Foster et al. (2006)	pubmed:16396496|mint:MINT-5218203	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-921030	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2711|refseq:NP_036883.1|refseq:XP_006246658.1|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007611"(learning or memory)|go:"GO:0007614"(short-term memory)|go:"GO:0007616"(long-term memory)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010021"(amylopectin biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031550"(positive regulation of brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044381"(glucose import in response to insulin stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046323"(glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0098694"(regulation of synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0098793"(presynapse)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002441("Glucose transporter, type 4 (GLUT4)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-189200|ensembl:ENSRNOG00000017226(gene)|ensembl:ENSRNOT00000023256(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)	rgd:620376|refseq:NP_612558.1|ensembl:ENSRNOG00000021808(gene)|ensembl:ENSRNOT00000037608(transcript)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0006665"(sphingolipid metabolic process)|go:"GO:0006694"(steroid biosynthetic process)|go:"GO:0016491"(oxidoreductase activity)|go:"GO:0030176"(integral component of endoplasmic reticulum membrane)|go:"GO:0030497"(fatty acid elongation)|go:"GO:0042761"(very long-chain fatty acid biosynthetic process)|go:"GO:0102758"(very-long-chain enoyl-CoA reductase activity)|interpro:IPR001104(3-oxo-5-alpha-steroid 4-dehydrogenase, C-terminal)|interpro:IPR029071|interpro:IPR039357|reactome:R-RNO-75876	-	-	-	caution:"The participant EBI-349571(P68370) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919386(Q7TP47) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920972(Q5XIP9) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-916419(P11980) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919578(Q8R491) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920554(Q5U3Z7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920647(Q5U2X8) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920585(Q7TP24) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-779677(P05426) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-915744(P02454) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|agonist:Insulin was shown to increase or decrease GLUT4 protein interactions in specific cases.|comment:"Insulin decreased GLUT4 interactions with the following proteins: Q9ER30 (Sarcosin), P09527 (Rab-7), O88960 (N-ethylmaleimide sensitive), P09456 (PKA I regulatory subunit), P27881 (Hexokinase type II), P07872 (Acyl-coenzyme A oxidase), Q6DGF1 (Isocitrate dehydrogenase), Q9EQX9 (Ubiquitin-conjugating), Q63446 (Polyubiquitin), P24268 (Cathepsin D), Q91XW0 (Heat shock protein 86), Q5FVH0 (unknown), P58405 (Striatin 3), Q62667 (Major vault protein), Q66H50 (unknown), Q09167 (splicing factor), Q9JHU5 (Arfaptin 1)."|comment:"Insulin increased GLUT4 interaction with the following proteins:Q9Z1P2 (R-actinin-1), P45592 (Cofilin), Q9QXQ0 (R-actinin-4), P26473 (ADP-ribosylation factor), P26437 (ADP-ribosylation factor),   Q7TNP1 (Basigin 2), Q6P6R2 (Dihydrolipoamide dehydrogenase),   P04797 (GAPDH), Q63081 (Protein disulfide isomerase), P29457 (47 kDa heat shock protein), Q9R1J8 (Leprecan), O88638 (Putative eps protein),   Q64375 (Synaptonemal complex)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:NDPK - Interactions involving proteins containing InterPro domain IPR001564, Nucleoside diphosphate kinase, core.	taxid:10116(rat-l6)|taxid:10116(Rattus norvegicus)	-	2006/02/15	2021/11/30	rogid:PbFY2lfrty8yw40Jq7ShR7xfuV410116	rogid:p1OxZP7UTZ8tk53e2xXhOg/Y4rM10116	intact-crc:44F3A2176D02515F|rigid:9RVm0UBcqQF4k06RGKO89Bg16Q8	false	myc tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P19357	uniprotkb:Q63965	intact:EBI-915426|uniprotkb:P97900|ensembl:ENSRNOP00000023256	intact:EBI-918690	psi-mi:glut4_rat(display_long)|uniprotkb:Glucose transporter type 4, insulin-responsive(gene name synonym)|uniprotkb:Slc2a4(gene name)|psi-mi:Slc2a4(display_short)|uniprotkb:Glut4(gene name synonym)	psi-mi:sfxn1_rat(display_long)|uniprotkb:Tricarboxylate carrier protein(gene name synonym)|uniprotkb:Sfxn1(gene name)|psi-mi:Sfxn1(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Foster et al. (2006)	pubmed:16396496|mint:MINT-5218203	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-921030	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2711|refseq:NP_036883.1|refseq:XP_006246658.1|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007611"(learning or memory)|go:"GO:0007614"(short-term memory)|go:"GO:0007616"(long-term memory)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010021"(amylopectin biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031550"(positive regulation of brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044381"(glucose import in response to insulin stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046323"(glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0098694"(regulation of synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0098793"(presynapse)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002441("Glucose transporter, type 4 (GLUT4)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-189200|ensembl:ENSRNOG00000017226(gene)|ensembl:ENSRNOT00000023256(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)	interpro:IPR004686(Tricarboxylate/iron carrier)|rgd:1308482|mint:Q63965|go:"GO:0005739"(mitochondrion)|go:"GO:0006730"(one-carbon metabolic process)|go:"GO:0006826"(iron ion transport)|go:"GO:0015194"(L-serine transmembrane transporter activity)|go:"GO:0015825"(L-serine transport)|go:"GO:0022857"(transmembrane transporter activity)|go:"GO:0022889"(serine transmembrane transporter activity)|go:"GO:0030218"(erythrocyte differentiation)|go:"GO:0031305"(integral component of mitochondrial inner membrane)|go:"GO:0042942"(D-serine transport)|go:"GO:0042945"(D-serine transmembrane transporter activity)|go:"GO:0140300"(serine import into mitochondrion)|go:"GO:1990542"(mitochondrial transmembrane transport)	-	-	-	caution:"The participant EBI-349571(P68370) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919386(Q7TP47) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920972(Q5XIP9) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-916419(P11980) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919578(Q8R491) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920554(Q5U3Z7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920647(Q5U2X8) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920585(Q7TP24) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-779677(P05426) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-915744(P02454) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|agonist:Insulin was shown to increase or decrease GLUT4 protein interactions in specific cases.|comment:"Insulin decreased GLUT4 interactions with the following proteins: Q9ER30 (Sarcosin), P09527 (Rab-7), O88960 (N-ethylmaleimide sensitive), P09456 (PKA I regulatory subunit), P27881 (Hexokinase type II), P07872 (Acyl-coenzyme A oxidase), Q6DGF1 (Isocitrate dehydrogenase), Q9EQX9 (Ubiquitin-conjugating), Q63446 (Polyubiquitin), P24268 (Cathepsin D), Q91XW0 (Heat shock protein 86), Q5FVH0 (unknown), P58405 (Striatin 3), Q62667 (Major vault protein), Q66H50 (unknown), Q09167 (splicing factor), Q9JHU5 (Arfaptin 1)."|comment:"Insulin increased GLUT4 interaction with the following proteins:Q9Z1P2 (R-actinin-1), P45592 (Cofilin), Q9QXQ0 (R-actinin-4), P26473 (ADP-ribosylation factor), P26437 (ADP-ribosylation factor),   Q7TNP1 (Basigin 2), Q6P6R2 (Dihydrolipoamide dehydrogenase),   P04797 (GAPDH), Q63081 (Protein disulfide isomerase), P29457 (47 kDa heat shock protein), Q9R1J8 (Leprecan), O88638 (Putative eps protein),   Q64375 (Synaptonemal complex)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:NDPK - Interactions involving proteins containing InterPro domain IPR001564, Nucleoside diphosphate kinase, core.	taxid:10116(rat-l6)|taxid:10116(Rattus norvegicus)	-	2006/02/15	2021/11/30	rogid:PbFY2lfrty8yw40Jq7ShR7xfuV410116	rogid:oy+pnAKs08HtNyA+d5es2yVFgPY10116	intact-crc:44F3A2176D02515F|rigid:9RVm0UBcqQF4k06RGKO89Bg16Q8	false	myc tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P19357	uniprotkb:Q63750	intact:EBI-915426|uniprotkb:P97900|ensembl:ENSRNOP00000023256	intact:EBI-918682|ensembl:ENSRNOP00000027585	psi-mi:glut4_rat(display_long)|uniprotkb:Glucose transporter type 4, insulin-responsive(gene name synonym)|uniprotkb:Slc2a4(gene name)|psi-mi:Slc2a4(display_short)|uniprotkb:Glut4(gene name synonym)	psi-mi:rm23_rat(display_long)|uniprotkb:L23 mitochondrial-related protein(gene name synonym)|uniprotkb:Mrpl23(gene name)|psi-mi:Mrpl23(display_short)|uniprotkb:L23mrp(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Foster et al. (2006)	pubmed:16396496|mint:MINT-5218203	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-921030	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2711|refseq:NP_036883.1|refseq:XP_006246658.1|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007611"(learning or memory)|go:"GO:0007614"(short-term memory)|go:"GO:0007616"(long-term memory)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010021"(amylopectin biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031550"(positive regulation of brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044381"(glucose import in response to insulin stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046323"(glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0098694"(regulation of synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0098793"(presynapse)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002441("Glucose transporter, type 4 (GLUT4)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-189200|ensembl:ENSRNOG00000017226(gene)|ensembl:ENSRNOT00000023256(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)	rgd:68343|refseq:NP_071974.1|ensembl:ENSRNOG00000020354(gene)|ensembl:ENSRNOT00000027585(transcript)|go:"GO:0003735"(structural constituent of ribosome)|go:"GO:0005761"(mitochondrial ribosome)|go:"GO:0005762"(mitochondrial large ribosomal subunit)|go:"GO:0032543"(mitochondrial translation)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR012678(Ribosomal protein L23/L15e, core)|interpro:IPR013025(Ribosomal protein L25/L23)|reactome:R-RNO-5389840|reactome:R-RNO-5419276	-	-	-	caution:"The participant EBI-349571(P68370) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919386(Q7TP47) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920972(Q5XIP9) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-916419(P11980) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919578(Q8R491) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920554(Q5U3Z7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920647(Q5U2X8) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920585(Q7TP24) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-779677(P05426) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-915744(P02454) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|agonist:Insulin was shown to increase or decrease GLUT4 protein interactions in specific cases.|comment:"Insulin decreased GLUT4 interactions with the following proteins: Q9ER30 (Sarcosin), P09527 (Rab-7), O88960 (N-ethylmaleimide sensitive), P09456 (PKA I regulatory subunit), P27881 (Hexokinase type II), P07872 (Acyl-coenzyme A oxidase), Q6DGF1 (Isocitrate dehydrogenase), Q9EQX9 (Ubiquitin-conjugating), Q63446 (Polyubiquitin), P24268 (Cathepsin D), Q91XW0 (Heat shock protein 86), Q5FVH0 (unknown), P58405 (Striatin 3), Q62667 (Major vault protein), Q66H50 (unknown), Q09167 (splicing factor), Q9JHU5 (Arfaptin 1)."|comment:"Insulin increased GLUT4 interaction with the following proteins:Q9Z1P2 (R-actinin-1), P45592 (Cofilin), Q9QXQ0 (R-actinin-4), P26473 (ADP-ribosylation factor), P26437 (ADP-ribosylation factor),   Q7TNP1 (Basigin 2), Q6P6R2 (Dihydrolipoamide dehydrogenase),   P04797 (GAPDH), Q63081 (Protein disulfide isomerase), P29457 (47 kDa heat shock protein), Q9R1J8 (Leprecan), O88638 (Putative eps protein),   Q64375 (Synaptonemal complex)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:NDPK - Interactions involving proteins containing InterPro domain IPR001564, Nucleoside diphosphate kinase, core.	taxid:10116(rat-l6)|taxid:10116(Rattus norvegicus)	-	2006/02/15	2021/11/30	rogid:PbFY2lfrty8yw40Jq7ShR7xfuV410116	rogid:CVCw0iBjIUIQha9QUn+ikXmSlRc10116	intact-crc:44F3A2176D02515F|rigid:9RVm0UBcqQF4k06RGKO89Bg16Q8	false	myc tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P19357	uniprotkb:Q63716	intact:EBI-915426|uniprotkb:P97900|ensembl:ENSRNOP00000023256	intact:EBI-918674|ensembl:ENSRNOP00000023132	psi-mi:glut4_rat(display_long)|uniprotkb:Glucose transporter type 4, insulin-responsive(gene name synonym)|uniprotkb:Slc2a4(gene name)|psi-mi:Slc2a4(display_short)|uniprotkb:Glut4(gene name synonym)	psi-mi:prdx1_rat(display_long)|uniprotkb:Thioredoxin peroxidase 2(gene name synonym)|uniprotkb:Thioredoxin-dependent peroxide reductase 2(gene name synonym)|uniprotkb:Heme-binding 23 kDa protein(gene name synonym)|uniprotkb:HBP23(gene name synonym)|uniprotkb:Prdx1(gene name)|psi-mi:Prdx1(display_short)|uniprotkb:Tdpx2(gene name synonym)|uniprotkb:Thioredoxin-dependent peroxiredoxin 1(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Foster et al. (2006)	pubmed:16396496|mint:MINT-5218203	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-921030	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2711|refseq:NP_036883.1|refseq:XP_006246658.1|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007611"(learning or memory)|go:"GO:0007614"(short-term memory)|go:"GO:0007616"(long-term memory)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010021"(amylopectin biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031550"(positive regulation of brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044381"(glucose import in response to insulin stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046323"(glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0098694"(regulation of synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0098793"(presynapse)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002441("Glucose transporter, type 4 (GLUT4)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-189200|ensembl:ENSRNOG00000017226(gene)|ensembl:ENSRNOT00000023256(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)	rgd:620039|refseq:NP_476455.1|ensembl:ENSRNOG00000017194(gene)|ensembl:ENSRNOT00000023132(transcript)|go:"GO:0000302"(response to reactive oxygen species)|go:"GO:0000791"(euchromatin)|go:"GO:0004601"(peroxidase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005782"(peroxisomal matrix)|go:"GO:0005829"(cytosol)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0008283"(cell population proliferation)|go:"GO:0008379"(thioredoxin peroxidase activity)|go:"GO:0019430"(removal of superoxide radicals)|go:"GO:0020037"(heme binding)|go:"GO:0030101"(natural killer cell activation)|go:"GO:0032872"(regulation of stress-activated MAPK cascade)|go:"GO:0034101"(erythrocyte homeostasis)|go:"GO:0042267"(natural killer cell mediated cytotoxicity)|go:"GO:0042744"(hydrogen peroxide catabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0045321"(leukocyte activation)|go:"GO:0045454"(cell redox homeostasis)|go:"GO:0051920"(peroxiredoxin activity)|go:"GO:1901222"(regulation of NIK/NF-kappaB signaling)|interpro:IPR000866(Alkyl hydroperoxide reductase/ Thiol specific antioxidant/ Mal allergen)|interpro:IPR013766(Thioredoxin domain)|interpro:IPR019479|interpro:IPR024706|interpro:IPR036249|mint:Q63716|rcsb pdb:1QQ2|rcsb pdb:2Z9S|reactome:R-RNO-3299685|reactome:R-RNO-5628897	-	-	-	caution:"The participant EBI-349571(P68370) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919386(Q7TP47) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920972(Q5XIP9) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-916419(P11980) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919578(Q8R491) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920554(Q5U3Z7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920647(Q5U2X8) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920585(Q7TP24) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-779677(P05426) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-915744(P02454) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|agonist:Insulin was shown to increase or decrease GLUT4 protein interactions in specific cases.|comment:"Insulin decreased GLUT4 interactions with the following proteins: Q9ER30 (Sarcosin), P09527 (Rab-7), O88960 (N-ethylmaleimide sensitive), P09456 (PKA I regulatory subunit), P27881 (Hexokinase type II), P07872 (Acyl-coenzyme A oxidase), Q6DGF1 (Isocitrate dehydrogenase), Q9EQX9 (Ubiquitin-conjugating), Q63446 (Polyubiquitin), P24268 (Cathepsin D), Q91XW0 (Heat shock protein 86), Q5FVH0 (unknown), P58405 (Striatin 3), Q62667 (Major vault protein), Q66H50 (unknown), Q09167 (splicing factor), Q9JHU5 (Arfaptin 1)."|comment:"Insulin increased GLUT4 interaction with the following proteins:Q9Z1P2 (R-actinin-1), P45592 (Cofilin), Q9QXQ0 (R-actinin-4), P26473 (ADP-ribosylation factor), P26437 (ADP-ribosylation factor),   Q7TNP1 (Basigin 2), Q6P6R2 (Dihydrolipoamide dehydrogenase),   P04797 (GAPDH), Q63081 (Protein disulfide isomerase), P29457 (47 kDa heat shock protein), Q9R1J8 (Leprecan), O88638 (Putative eps protein),   Q64375 (Synaptonemal complex)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:NDPK - Interactions involving proteins containing InterPro domain IPR001564, Nucleoside diphosphate kinase, core.	taxid:10116(rat-l6)|taxid:10116(Rattus norvegicus)	-	2006/02/15	2021/11/30	rogid:PbFY2lfrty8yw40Jq7ShR7xfuV410116	rogid:6Yx5rIs6p9cg57ePcRAtiWUM7p010116	intact-crc:44F3A2176D02515F|rigid:9RVm0UBcqQF4k06RGKO89Bg16Q8	false	myc tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P19357	uniprotkb:Q63699	intact:EBI-915426|uniprotkb:P97900|ensembl:ENSRNOP00000023256	intact:EBI-847090|uniprotkb:O09136	psi-mi:glut4_rat(display_long)|uniprotkb:Glucose transporter type 4, insulin-responsive(gene name synonym)|uniprotkb:Slc2a4(gene name)|psi-mi:Slc2a4(display_short)|uniprotkb:Glut4(gene name synonym)	psi-mi:cdk2_rat(display_long)|uniprotkb:Cdk2(gene name)|psi-mi:Cdk2(display_short)|uniprotkb:Cell division protein kinase 2(gene name synonym)|uniprotkb:Cdkn2(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Foster et al. (2006)	pubmed:16396496|mint:MINT-5218203	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-921030	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2711|refseq:NP_036883.1|refseq:XP_006246658.1|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007611"(learning or memory)|go:"GO:0007614"(short-term memory)|go:"GO:0007616"(long-term memory)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010021"(amylopectin biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031550"(positive regulation of brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044381"(glucose import in response to insulin stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046323"(glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0098694"(regulation of synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0098793"(presynapse)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002441("Glucose transporter, type 4 (GLUT4)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-189200|ensembl:ENSRNOG00000017226(gene)|ensembl:ENSRNOT00000023256(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)	dip:DIP-36536N|rgd:70486|reactome:R-RNO-9616222|reactome:R-RNO-6804756|reactome:R-RNO-1538133|reactome:R-RNO-176187|reactome:R-RNO-176408|reactome:R-RNO-187577|reactome:R-RNO-2559582|reactome:R-RNO-2559586|reactome:R-RNO-5693607|reactome:R-RNO-6804116|reactome:R-RNO-6804757|reactome:R-RNO-68911|reactome:R-RNO-68949|reactome:R-RNO-68962|reactome:R-RNO-69017|reactome:R-RNO-69200|reactome:R-RNO-69202|reactome:R-RNO-69273|reactome:R-RNO-69563|reactome:R-RNO-69656|reactome:R-RNO-8849470|reactome:R-RNO-171319|reactome:R-RNO-69231|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0000307"(cyclin-dependent protein kinase holoenzyme complex)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000793"(condensed chromosome)|go:"GO:0000805"(X chromosome)|go:"GO:0000806"(Y chromosome)|go:"GO:0002088"(lens development in camera-type eye)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004693"(cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0005829"(cytosol)|go:"GO:0006281"(DNA repair)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006813"(potassium ion transport)|go:"GO:0007099"(centriole replication)|go:"GO:0007165"(signal transduction)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009636"(response to toxic substance)|go:"GO:0010389"(regulation of G2/M transition of mitotic cell cycle)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0015030"(Cajal body)|go:"GO:0016301"(kinase activity)|go:"GO:0016572"(histone phosphorylation)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030332"(cyclin binding)|go:"GO:0031100"(animal organ regeneration)|go:"GO:0032298"(positive regulation of DNA-dependent DNA replication initiation)|go:"GO:0032355"(response to estradiol)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042493"|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045471"(response to ethanol)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046686"(response to cadmium ion)|go:"GO:0051301"(cell division)|go:"GO:0051321"(meiotic cell cycle)|go:"GO:0051591"(response to cAMP)|go:"GO:0051602"(response to electrical stimulus)|go:"GO:0060968"(obsolete regulation of gene silencing)|go:"GO:0097123"(cyclin A1-CDK2 complex)|go:"GO:0097124"(cyclin A2-CDK2 complex)|go:"GO:0097134"(cyclin E1-CDK2 complex)|go:"GO:0097135"(cyclin E2-CDK2 complex)|go:"GO:0097472"(cyclin-dependent protein kinase activity)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)	-	-	-	caution:"The participant EBI-349571(P68370) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919386(Q7TP47) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920972(Q5XIP9) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-916419(P11980) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919578(Q8R491) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920554(Q5U3Z7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920647(Q5U2X8) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920585(Q7TP24) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-779677(P05426) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-915744(P02454) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|agonist:Insulin was shown to increase or decrease GLUT4 protein interactions in specific cases.|comment:"Insulin decreased GLUT4 interactions with the following proteins: Q9ER30 (Sarcosin), P09527 (Rab-7), O88960 (N-ethylmaleimide sensitive), P09456 (PKA I regulatory subunit), P27881 (Hexokinase type II), P07872 (Acyl-coenzyme A oxidase), Q6DGF1 (Isocitrate dehydrogenase), Q9EQX9 (Ubiquitin-conjugating), Q63446 (Polyubiquitin), P24268 (Cathepsin D), Q91XW0 (Heat shock protein 86), Q5FVH0 (unknown), P58405 (Striatin 3), Q62667 (Major vault protein), Q66H50 (unknown), Q09167 (splicing factor), Q9JHU5 (Arfaptin 1)."|comment:"Insulin increased GLUT4 interaction with the following proteins:Q9Z1P2 (R-actinin-1), P45592 (Cofilin), Q9QXQ0 (R-actinin-4), P26473 (ADP-ribosylation factor), P26437 (ADP-ribosylation factor),   Q7TNP1 (Basigin 2), Q6P6R2 (Dihydrolipoamide dehydrogenase),   P04797 (GAPDH), Q63081 (Protein disulfide isomerase), P29457 (47 kDa heat shock protein), Q9R1J8 (Leprecan), O88638 (Putative eps protein),   Q64375 (Synaptonemal complex)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:NDPK - Interactions involving proteins containing InterPro domain IPR001564, Nucleoside diphosphate kinase, core.	taxid:10116(rat-l6)|taxid:10116(Rattus norvegicus)	-	2006/02/15	2021/11/30	rogid:PbFY2lfrty8yw40Jq7ShR7xfuV410116	rogid:IfFEQhjEEentVmkYoZsOwM95H9s10116	intact-crc:44F3A2176D02515F|rigid:9RVm0UBcqQF4k06RGKO89Bg16Q8	false	myc tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P19357	uniprotkb:Q63635	intact:EBI-915426|uniprotkb:P97900|ensembl:ENSRNOP00000023256	intact:EBI-398854|ensembl:ENSRNOP00000037536	psi-mi:glut4_rat(display_long)|uniprotkb:Glucose transporter type 4, insulin-responsive(gene name synonym)|uniprotkb:Slc2a4(gene name)|psi-mi:Slc2a4(display_short)|uniprotkb:Glut4(gene name synonym)	psi-mi:stx6_rat(display_long)|uniprotkb:Stx6(gene name)|psi-mi:Stx6(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Foster et al. (2006)	pubmed:16396496|mint:MINT-5218203	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-921030	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2711|refseq:NP_036883.1|refseq:XP_006246658.1|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007611"(learning or memory)|go:"GO:0007614"(short-term memory)|go:"GO:0007616"(long-term memory)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010021"(amylopectin biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031550"(positive regulation of brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044381"(glucose import in response to insulin stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046323"(glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0098694"(regulation of synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0098793"(presynapse)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002441("Glucose transporter, type 4 (GLUT4)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-189200|ensembl:ENSRNOG00000017226(gene)|ensembl:ENSRNOT00000023256(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)	rgd:61915|refseq:NP_113853.1|ensembl:ENSRNOG00000003402(gene)|ensembl:ENSRNOT00000035145(transcript)|go:"GO:0000149"(SNARE binding)|go:"GO:0005484"(SNAP receptor activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005769"(early endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006906"(vesicle fusion)|go:"GO:0007032"(endosome organization)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0012505"(endomembrane system)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016189"(synaptic vesicle to endosome fusion)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0019905"(syntaxin binding)|go:"GO:0030285"(integral component of synaptic vesicle membrane)|go:"GO:0031201"(SNARE complex)|go:"GO:0032456"(endocytic recycling)|go:"GO:0032588"(trans-Golgi network membrane)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0042147"(retrograde transport, endosome to Golgi)|go:"GO:0043195"(terminal bouton)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0048193"(Golgi vesicle transport)|go:"GO:0048278"(vesicle docking)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0090161"(Golgi ribbon formation)|go:"GO:1903827"|interpro:IPR000727(Target SNARE coiled-coil region)|interpro:IPR006012(Syntaxin/epimorphin, conserved site)|interpro:IPR010989(t-SNARE)|interpro:IPR015260(Syntaxin 6, N-terminal)|mint:Q63635|rcsb pdb:1LVF|reactome:R-RNO-6811438|reactome:R-RNO-6811440	-	-	-	caution:"The participant EBI-349571(P68370) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919386(Q7TP47) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920972(Q5XIP9) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-916419(P11980) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919578(Q8R491) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920554(Q5U3Z7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920647(Q5U2X8) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920585(Q7TP24) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-779677(P05426) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-915744(P02454) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|agonist:Insulin was shown to increase or decrease GLUT4 protein interactions in specific cases.|comment:"Insulin decreased GLUT4 interactions with the following proteins: Q9ER30 (Sarcosin), P09527 (Rab-7), O88960 (N-ethylmaleimide sensitive), P09456 (PKA I regulatory subunit), P27881 (Hexokinase type II), P07872 (Acyl-coenzyme A oxidase), Q6DGF1 (Isocitrate dehydrogenase), Q9EQX9 (Ubiquitin-conjugating), Q63446 (Polyubiquitin), P24268 (Cathepsin D), Q91XW0 (Heat shock protein 86), Q5FVH0 (unknown), P58405 (Striatin 3), Q62667 (Major vault protein), Q66H50 (unknown), Q09167 (splicing factor), Q9JHU5 (Arfaptin 1)."|comment:"Insulin increased GLUT4 interaction with the following proteins:Q9Z1P2 (R-actinin-1), P45592 (Cofilin), Q9QXQ0 (R-actinin-4), P26473 (ADP-ribosylation factor), P26437 (ADP-ribosylation factor),   Q7TNP1 (Basigin 2), Q6P6R2 (Dihydrolipoamide dehydrogenase),   P04797 (GAPDH), Q63081 (Protein disulfide isomerase), P29457 (47 kDa heat shock protein), Q9R1J8 (Leprecan), O88638 (Putative eps protein),   Q64375 (Synaptonemal complex)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:NDPK - Interactions involving proteins containing InterPro domain IPR001564, Nucleoside diphosphate kinase, core.	taxid:10116(rat-l6)|taxid:10116(Rattus norvegicus)	-	2006/02/15	2021/11/30	rogid:PbFY2lfrty8yw40Jq7ShR7xfuV410116	rogid:mxWw+8l//wW59ZQonfoo/lPa3Ts10116	intact-crc:44F3A2176D02515F|rigid:9RVm0UBcqQF4k06RGKO89Bg16Q8	false	myc tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P19357	uniprotkb:Q63615	intact:EBI-915426|uniprotkb:P97900|ensembl:ENSRNOP00000023256	intact:EBI-918669	psi-mi:glut4_rat(display_long)|uniprotkb:Glucose transporter type 4, insulin-responsive(gene name synonym)|uniprotkb:Slc2a4(gene name)|psi-mi:Slc2a4(display_short)|uniprotkb:Glut4(gene name synonym)	psi-mi:vp33a_rat(display_long)|uniprotkb:Vps33a(gene name)|psi-mi:Vps33a(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Foster et al. (2006)	pubmed:16396496|mint:MINT-5218203	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-921030	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2711|refseq:NP_036883.1|refseq:XP_006246658.1|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007611"(learning or memory)|go:"GO:0007614"(short-term memory)|go:"GO:0007616"(long-term memory)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010021"(amylopectin biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031550"(positive regulation of brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044381"(glucose import in response to insulin stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046323"(glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0098694"(regulation of synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0098793"(presynapse)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002441("Glucose transporter, type 4 (GLUT4)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-189200|ensembl:ENSRNOG00000017226(gene)|ensembl:ENSRNOT00000023256(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)	interpro:IPR001619(Sec1-like protein)|rgd:620643|interpro:IPR027121|interpro:IPR027482|interpro:IPR036045|interpro:IPR043154|interpro:IPR043155|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005769"(early endosome)|go:"GO:0005770"(late endosome)|go:"GO:0005773"(vacuole)|go:"GO:0005776"(autophagosome)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0008333"(endosome to lysosome transport)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030220"(platelet formation)|go:"GO:0030897"(HOPS complex)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031902"(late endosome membrane)|go:"GO:0032400"(melanosome localization)|go:"GO:0032418"(lysosome localization)|go:"GO:0033263"(CORVET complex)|go:"GO:0035751"(regulation of lysosomal lumen pH)|go:"GO:0043473"(pigmentation)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0048070"(regulation of developmental pigmentation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0097352"(autophagosome maturation)	-	-	-	caution:"The participant EBI-349571(P68370) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919386(Q7TP47) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920972(Q5XIP9) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-916419(P11980) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919578(Q8R491) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920554(Q5U3Z7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920647(Q5U2X8) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920585(Q7TP24) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-779677(P05426) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-915744(P02454) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|agonist:Insulin was shown to increase or decrease GLUT4 protein interactions in specific cases.|comment:"Insulin decreased GLUT4 interactions with the following proteins: Q9ER30 (Sarcosin), P09527 (Rab-7), O88960 (N-ethylmaleimide sensitive), P09456 (PKA I regulatory subunit), P27881 (Hexokinase type II), P07872 (Acyl-coenzyme A oxidase), Q6DGF1 (Isocitrate dehydrogenase), Q9EQX9 (Ubiquitin-conjugating), Q63446 (Polyubiquitin), P24268 (Cathepsin D), Q91XW0 (Heat shock protein 86), Q5FVH0 (unknown), P58405 (Striatin 3), Q62667 (Major vault protein), Q66H50 (unknown), Q09167 (splicing factor), Q9JHU5 (Arfaptin 1)."|comment:"Insulin increased GLUT4 interaction with the following proteins:Q9Z1P2 (R-actinin-1), P45592 (Cofilin), Q9QXQ0 (R-actinin-4), P26473 (ADP-ribosylation factor), P26437 (ADP-ribosylation factor),   Q7TNP1 (Basigin 2), Q6P6R2 (Dihydrolipoamide dehydrogenase),   P04797 (GAPDH), Q63081 (Protein disulfide isomerase), P29457 (47 kDa heat shock protein), Q9R1J8 (Leprecan), O88638 (Putative eps protein),   Q64375 (Synaptonemal complex)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:NDPK - Interactions involving proteins containing InterPro domain IPR001564, Nucleoside diphosphate kinase, core.	taxid:10116(rat-l6)|taxid:10116(Rattus norvegicus)	-	2006/02/15	2021/11/30	rogid:PbFY2lfrty8yw40Jq7ShR7xfuV410116	rogid:euzyw0LRw3iDq+pwOwANlEb2xIE10116	intact-crc:44F3A2176D02515F|rigid:9RVm0UBcqQF4k06RGKO89Bg16Q8	false	myc tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P19357	uniprotkb:Q63598	intact:EBI-915426|uniprotkb:P97900|ensembl:ENSRNOP00000023256	intact:EBI-918660	psi-mi:glut4_rat(display_long)|uniprotkb:Glucose transporter type 4, insulin-responsive(gene name synonym)|uniprotkb:Slc2a4(gene name)|psi-mi:Slc2a4(display_short)|uniprotkb:Glut4(gene name synonym)	psi-mi:plst_rat(display_long)|uniprotkb:T-plastin(gene name synonym)|uniprotkb:Pls3(gene name)|psi-mi:Pls3(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Foster et al. (2006)	pubmed:16396496|mint:MINT-5218203	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-921030	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2711|refseq:NP_036883.1|refseq:XP_006246658.1|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007611"(learning or memory)|go:"GO:0007614"(short-term memory)|go:"GO:0007616"(long-term memory)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010021"(amylopectin biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031550"(positive regulation of brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044381"(glucose import in response to insulin stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046323"(glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0098694"(regulation of synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0098793"(presynapse)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002441("Glucose transporter, type 4 (GLUT4)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-189200|ensembl:ENSRNOG00000017226(gene)|ensembl:ENSRNOT00000023256(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)	rgd:621409|interpro:IPR001589(Actinin-type, actin-binding, conserved site)|interpro:IPR001715(Calponin-like actin-binding)|interpro:IPR011992(EF-Hand type)|interpro:IPR018247|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR036872|interpro:IPR039956|interpro:IPR039959|go:"GO:0005509"(calcium ion binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005884"(actin filament)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0032420"(stereocilium)|go:"GO:0032432"(actin filament bundle)|go:"GO:0042491"(inner ear auditory receptor cell differentiation)|go:"GO:0051015"(actin filament binding)|go:"GO:0051017"(actin filament bundle assembly)|go:"GO:0051639"(actin filament network formation)|go:"GO:0060348"(bone development)|go:"GO:0098693"(regulation of synaptic vesicle cycle)|go:"GO:0098699"(structural constituent of presynaptic actin cytoskeleton)	-	-	-	caution:"The participant EBI-349571(P68370) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919386(Q7TP47) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920972(Q5XIP9) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-916419(P11980) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919578(Q8R491) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920554(Q5U3Z7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920647(Q5U2X8) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920585(Q7TP24) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-779677(P05426) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-915744(P02454) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|agonist:Insulin was shown to increase or decrease GLUT4 protein interactions in specific cases.|comment:"Insulin decreased GLUT4 interactions with the following proteins: Q9ER30 (Sarcosin), P09527 (Rab-7), O88960 (N-ethylmaleimide sensitive), P09456 (PKA I regulatory subunit), P27881 (Hexokinase type II), P07872 (Acyl-coenzyme A oxidase), Q6DGF1 (Isocitrate dehydrogenase), Q9EQX9 (Ubiquitin-conjugating), Q63446 (Polyubiquitin), P24268 (Cathepsin D), Q91XW0 (Heat shock protein 86), Q5FVH0 (unknown), P58405 (Striatin 3), Q62667 (Major vault protein), Q66H50 (unknown), Q09167 (splicing factor), Q9JHU5 (Arfaptin 1)."|comment:"Insulin increased GLUT4 interaction with the following proteins:Q9Z1P2 (R-actinin-1), P45592 (Cofilin), Q9QXQ0 (R-actinin-4), P26473 (ADP-ribosylation factor), P26437 (ADP-ribosylation factor),   Q7TNP1 (Basigin 2), Q6P6R2 (Dihydrolipoamide dehydrogenase),   P04797 (GAPDH), Q63081 (Protein disulfide isomerase), P29457 (47 kDa heat shock protein), Q9R1J8 (Leprecan), O88638 (Putative eps protein),   Q64375 (Synaptonemal complex)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:NDPK - Interactions involving proteins containing InterPro domain IPR001564, Nucleoside diphosphate kinase, core.	taxid:10116(rat-l6)|taxid:10116(Rattus norvegicus)	-	2006/02/15	2021/11/30	rogid:PbFY2lfrty8yw40Jq7ShR7xfuV410116	rogid:M2wtZXReFK/rBrlLp2osmka2OEo10116	intact-crc:44F3A2176D02515F|rigid:9RVm0UBcqQF4k06RGKO89Bg16Q8	false	myc tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P19357	uniprotkb:Q63584	intact:EBI-915426|uniprotkb:P97900|ensembl:ENSRNOP00000023256	intact:EBI-918648|uniprotkb:Q9R0W6|ensembl:ENSRNOP00000010512	psi-mi:glut4_rat(display_long)|uniprotkb:Glucose transporter type 4, insulin-responsive(gene name synonym)|uniprotkb:Slc2a4(gene name)|psi-mi:Slc2a4(display_short)|uniprotkb:Glut4(gene name synonym)	psi-mi:tmeda_rat(display_long)|uniprotkb:21 kDa transmembrane-trafficking protein(gene name synonym)|uniprotkb:Transmembrane protein Tmp21(gene name synonym)|uniprotkb:Tmed10(gene name)|psi-mi:Tmed10(display_short)|uniprotkb:Tmp21(gene name synonym)|uniprotkb:p24 family protein delta-1(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Foster et al. (2006)	pubmed:16396496|mint:MINT-5218203	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-921030	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2711|refseq:NP_036883.1|refseq:XP_006246658.1|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007611"(learning or memory)|go:"GO:0007614"(short-term memory)|go:"GO:0007616"(long-term memory)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010021"(amylopectin biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031550"(positive regulation of brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044381"(glucose import in response to insulin stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046323"(glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0098694"(regulation of synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0098793"(presynapse)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002441("Glucose transporter, type 4 (GLUT4)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-189200|ensembl:ENSRNOG00000017226(gene)|ensembl:ENSRNOT00000023256(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)	rgd:620970|refseq:NP_445919.1|ensembl:ENSRNOG00000007901(gene)|ensembl:ENSRNOT00000010512(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001822"(kidney development)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005793"(endoplasmic reticulum-Golgi intermediate compartment)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005801"(cis-Golgi network)|go:"GO:0005886"(plasma membrane)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006888"(endoplasmic reticulum to Golgi vesicle-mediated transport)|go:"GO:0006890"(retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum)|go:"GO:0006903"(vesicle targeting)|go:"GO:0007030"(Golgi organization)|go:"GO:0008320"(protein transmembrane transporter activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019905"(syntaxin binding)|go:"GO:0030134"(COPII-coated ER to Golgi transport vesicle)|go:"GO:0030137"(COPI-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030658"(transport vesicle membrane)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0032732"(positive regulation of interleukin-1 production)|go:"GO:0033116"(endoplasmic reticulum-Golgi intermediate compartment membrane)|go:"GO:0035964"(COPI-coated vesicle budding)|go:"GO:0042470"(melanosome)|go:"GO:0042589"(zymogen granule membrane)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043279"(response to alkaloid)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045055"(regulated exocytosis)|go:"GO:0048199"(vesicle targeting, to, from or within Golgi)|go:"GO:0050714"(positive regulation of protein secretion)|go:"GO:0070765"(gamma-secretase complex)|go:"GO:0106272"(protein localization to ERGIC)|go:"GO:0106273"(cytosol to ERGIC protein transport)|go:"GO:1902003"(regulation of amyloid-beta formation)|go:"GO:1902960"(negative regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process)|interpro:IPR009038(GOLD)|interpro:IPR015720(TMP21 related)|rcsb pdb:5AZX|rcsb pdb:5AZY|reactome:R-RNO-204005|reactome:R-RNO-5694530|reactome:R-RNO-6807878|reactome:R-RNO-6811434	-	-	-	caution:"The participant EBI-349571(P68370) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919386(Q7TP47) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920972(Q5XIP9) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-916419(P11980) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919578(Q8R491) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920554(Q5U3Z7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920647(Q5U2X8) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920585(Q7TP24) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-779677(P05426) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-915744(P02454) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|agonist:Insulin was shown to increase or decrease GLUT4 protein interactions in specific cases.|comment:"Insulin decreased GLUT4 interactions with the following proteins: Q9ER30 (Sarcosin), P09527 (Rab-7), O88960 (N-ethylmaleimide sensitive), P09456 (PKA I regulatory subunit), P27881 (Hexokinase type II), P07872 (Acyl-coenzyme A oxidase), Q6DGF1 (Isocitrate dehydrogenase), Q9EQX9 (Ubiquitin-conjugating), Q63446 (Polyubiquitin), P24268 (Cathepsin D), Q91XW0 (Heat shock protein 86), Q5FVH0 (unknown), P58405 (Striatin 3), Q62667 (Major vault protein), Q66H50 (unknown), Q09167 (splicing factor), Q9JHU5 (Arfaptin 1)."|comment:"Insulin increased GLUT4 interaction with the following proteins:Q9Z1P2 (R-actinin-1), P45592 (Cofilin), Q9QXQ0 (R-actinin-4), P26473 (ADP-ribosylation factor), P26437 (ADP-ribosylation factor),   Q7TNP1 (Basigin 2), Q6P6R2 (Dihydrolipoamide dehydrogenase),   P04797 (GAPDH), Q63081 (Protein disulfide isomerase), P29457 (47 kDa heat shock protein), Q9R1J8 (Leprecan), O88638 (Putative eps protein),   Q64375 (Synaptonemal complex)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:NDPK - Interactions involving proteins containing InterPro domain IPR001564, Nucleoside diphosphate kinase, core.	taxid:10116(rat-l6)|taxid:10116(Rattus norvegicus)	-	2006/02/15	2021/11/30	rogid:PbFY2lfrty8yw40Jq7ShR7xfuV410116	rogid:E5kc3oLWmHd2jYmV7UgVVX1IdWo10116	intact-crc:44F3A2176D02515F|rigid:9RVm0UBcqQF4k06RGKO89Bg16Q8	false	myc tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P19357	uniprotkb:Q63570	intact:EBI-915426|uniprotkb:P97900|ensembl:ENSRNOP00000023256	intact:EBI-918637|ensembl:ENSRNOP00000025819	psi-mi:glut4_rat(display_long)|uniprotkb:Glucose transporter type 4, insulin-responsive(gene name synonym)|uniprotkb:Slc2a4(gene name)|psi-mi:Slc2a4(display_short)|uniprotkb:Glut4(gene name synonym)	psi-mi:prs6b_rat(display_long)|uniprotkb:Proteasome 26S subunit ATPase 4(gene name synonym)|uniprotkb:Tat-binding protein 7(gene name synonym)|uniprotkb:Psmc4(gene name)|psi-mi:Psmc4(display_short)|uniprotkb:Tbp7(gene name synonym)|uniprotkb:26S proteasome AAA-ATPase subunit RPT3(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Foster et al. (2006)	pubmed:16396496|mint:MINT-5218203	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-921030	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2711|refseq:NP_036883.1|refseq:XP_006246658.1|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007611"(learning or memory)|go:"GO:0007614"(short-term memory)|go:"GO:0007616"(long-term memory)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010021"(amylopectin biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031550"(positive regulation of brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044381"(glucose import in response to insulin stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046323"(glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0098694"(regulation of synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0098793"(presynapse)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002441("Glucose transporter, type 4 (GLUT4)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-189200|ensembl:ENSRNOG00000017226(gene)|ensembl:ENSRNOT00000023256(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)	rgd:621102|refseq:NP_476463.1|ensembl:ENSRNOG00000018994(gene)|ensembl:ENSRNOT00000025819(transcript)|go:"GO:0000502"(proteasome complex)|go:"GO:0001824"(blastocyst development)|go:"GO:0005524"(ATP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0008540"(proteasome regulatory particle, base subcomplex)|go:"GO:0016234"(inclusion body)|go:"GO:0022624"(proteasome accessory complex)|go:"GO:0030163"(protein catabolic process)|go:"GO:0031597"(cytosolic proteasome complex)|go:"GO:0036402"(proteasome-activating activity)|go:"GO:0045202"(synapse)|go:"GO:0045899"(positive regulation of RNA polymerase II transcription preinitiation complex assembly)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR003959(AAA ATPase, core)|interpro:IPR003960(AAA ATPase, conserved site)|interpro:IPR005937(26S proteasome subunit P45)|interpro:IPR027417|interpro:IPR032501|interpro:IPR035256|interpro:IPR041569|rcsb pdb:2DWZ|rcsb pdb:6EPC|rcsb pdb:6EPD|rcsb pdb:6EPE|rcsb pdb:6EPF|reactome:R-RNO-1169091|reactome:R-RNO-1234176|reactome:R-RNO-1236978|reactome:R-RNO-174084|reactome:R-RNO-174154|reactome:R-RNO-174178|reactome:R-RNO-174184|reactome:R-RNO-187577|reactome:R-RNO-195253|reactome:R-RNO-2467813|reactome:R-RNO-349425|reactome:R-RNO-350562|reactome:R-RNO-382556|reactome:R-RNO-450408|reactome:R-RNO-4608870|reactome:R-RNO-4641257|reactome:R-RNO-4641258|reactome:R-RNO-5358346|reactome:R-RNO-5607761|reactome:R-RNO-5610780|reactome:R-RNO-5610785|reactome:R-RNO-5632684|reactome:R-RNO-5658442|reactome:R-RNO-5668541|reactome:R-RNO-5676590|reactome:R-RNO-5687128|reactome:R-RNO-5689603|reactome:R-RNO-5689880|reactome:R-RNO-68827|reactome:R-RNO-68949|reactome:R-RNO-69017|reactome:R-RNO-69481|reactome:R-RNO-69601|reactome:R-RNO-75815|reactome:R-RNO-8852276|reactome:R-RNO-8854050|reactome:R-RNO-8932339|reactome:R-RNO-8939236|reactome:R-RNO-8941858|reactome:R-RNO-8948751|reactome:R-RNO-8951664|reactome:R-RNO-983168	-	-	-	caution:"The participant EBI-349571(P68370) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919386(Q7TP47) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920972(Q5XIP9) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-916419(P11980) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919578(Q8R491) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920554(Q5U3Z7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920647(Q5U2X8) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920585(Q7TP24) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-779677(P05426) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-915744(P02454) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|agonist:Insulin was shown to increase or decrease GLUT4 protein interactions in specific cases.|comment:"Insulin decreased GLUT4 interactions with the following proteins: Q9ER30 (Sarcosin), P09527 (Rab-7), O88960 (N-ethylmaleimide sensitive), P09456 (PKA I regulatory subunit), P27881 (Hexokinase type II), P07872 (Acyl-coenzyme A oxidase), Q6DGF1 (Isocitrate dehydrogenase), Q9EQX9 (Ubiquitin-conjugating), Q63446 (Polyubiquitin), P24268 (Cathepsin D), Q91XW0 (Heat shock protein 86), Q5FVH0 (unknown), P58405 (Striatin 3), Q62667 (Major vault protein), Q66H50 (unknown), Q09167 (splicing factor), Q9JHU5 (Arfaptin 1)."|comment:"Insulin increased GLUT4 interaction with the following proteins:Q9Z1P2 (R-actinin-1), P45592 (Cofilin), Q9QXQ0 (R-actinin-4), P26473 (ADP-ribosylation factor), P26437 (ADP-ribosylation factor),   Q7TNP1 (Basigin 2), Q6P6R2 (Dihydrolipoamide dehydrogenase),   P04797 (GAPDH), Q63081 (Protein disulfide isomerase), P29457 (47 kDa heat shock protein), Q9R1J8 (Leprecan), O88638 (Putative eps protein),   Q64375 (Synaptonemal complex)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:NDPK - Interactions involving proteins containing InterPro domain IPR001564, Nucleoside diphosphate kinase, core.	taxid:10116(rat-l6)|taxid:10116(Rattus norvegicus)	-	2006/02/15	2021/11/30	rogid:PbFY2lfrty8yw40Jq7ShR7xfuV410116	rogid:sMGdo51UJT7c6ngmxSDrYfLvkLc10116	intact-crc:44F3A2176D02515F|rigid:9RVm0UBcqQF4k06RGKO89Bg16Q8	false	myc tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P19357	uniprotkb:Q63569	intact:EBI-915426|uniprotkb:P97900|ensembl:ENSRNOP00000023256	intact:EBI-918627|uniprotkb:P97638	psi-mi:glut4_rat(display_long)|uniprotkb:Glucose transporter type 4, insulin-responsive(gene name synonym)|uniprotkb:Slc2a4(gene name)|psi-mi:Slc2a4(display_short)|uniprotkb:Glut4(gene name synonym)	psi-mi:prs6a_rat(display_long)|uniprotkb:Proteasome 26S subunit ATPase 3(gene name synonym)|uniprotkb:Tat-binding protein 1(gene name synonym)|uniprotkb:Spermatogenic cell/sperm-associated Tat-binding protein homolog SATA(gene name synonym)|uniprotkb:Psmc3(gene name)|psi-mi:Psmc3(display_short)|uniprotkb:Tbp1(gene name synonym)|uniprotkb:26S proteasome AAA-ATPase subunit RPT5(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Foster et al. (2006)	pubmed:16396496|mint:MINT-5218203	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-921030	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2711|refseq:NP_036883.1|refseq:XP_006246658.1|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007611"(learning or memory)|go:"GO:0007614"(short-term memory)|go:"GO:0007616"(long-term memory)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010021"(amylopectin biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031550"(positive regulation of brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044381"(glucose import in response to insulin stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046323"(glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0098694"(regulation of synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0098793"(presynapse)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002441("Glucose transporter, type 4 (GLUT4)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-189200|ensembl:ENSRNOG00000017226(gene)|ensembl:ENSRNOT00000023256(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)	rgd:61905|refseq:NP_113783.1|interpro:IPR005937(26S proteasome subunit P45)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR003959(AAA ATPase, core)|interpro:IPR003960(AAA ATPase, conserved site)|reactome:R-RNO-8932339|interpro:IPR027417|interpro:IPR035254|rcsb pdb:6EPC|rcsb pdb:6EPD|rcsb pdb:6EPE|rcsb pdb:6EPF|interpro:IPR032501|interpro:IPR041569|reactome:R-RNO-174084|reactome:R-RNO-5689603|reactome:R-RNO-5689880|reactome:R-RNO-6798695|reactome:R-RNO-68827|reactome:R-RNO-8951664|reactome:R-RNO-1169091|reactome:R-RNO-1234176|reactome:R-RNO-1236978|reactome:R-RNO-174154|reactome:R-RNO-174178|reactome:R-RNO-174184|reactome:R-RNO-187577|reactome:R-RNO-195253|reactome:R-RNO-2467813|reactome:R-RNO-349425|reactome:R-RNO-350562|reactome:R-RNO-382556|reactome:R-RNO-450408|reactome:R-RNO-4608870|reactome:R-RNO-4641257|reactome:R-RNO-4641258|reactome:R-RNO-5358346|reactome:R-RNO-5607761|reactome:R-RNO-5610780|reactome:R-RNO-5610785|reactome:R-RNO-5632684|reactome:R-RNO-5658442|reactome:R-RNO-5668541|reactome:R-RNO-5676590|reactome:R-RNO-5687128|reactome:R-RNO-68949|reactome:R-RNO-69017|reactome:R-RNO-69481|reactome:R-RNO-69601|reactome:R-RNO-75815|reactome:R-RNO-8852276|reactome:R-RNO-8854050|reactome:R-RNO-8939236|reactome:R-RNO-8941858|reactome:R-RNO-8948751|reactome:R-RNO-983168|go:"GO:0000502"(proteasome complex)|go:"GO:0000932"(P-body)|go:"GO:0001824"(blastocyst development)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0008540"(proteasome regulatory particle, base subcomplex)|go:"GO:0022624"(proteasome accessory complex)|go:"GO:0030163"(protein catabolic process)|go:"GO:0036402"(proteasome-activating activity)|go:"GO:0042802"(identical protein binding)|go:"GO:0043921"(modulation by host of viral transcription)|go:"GO:0045899"(positive regulation of RNA polymerase II transcription preinitiation complex assembly)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048471"(perinuclear region of cytoplasm)	-	-	-	caution:"The participant EBI-349571(P68370) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919386(Q7TP47) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920972(Q5XIP9) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-916419(P11980) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919578(Q8R491) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920554(Q5U3Z7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920647(Q5U2X8) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920585(Q7TP24) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-779677(P05426) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-915744(P02454) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|agonist:Insulin was shown to increase or decrease GLUT4 protein interactions in specific cases.|comment:"Insulin decreased GLUT4 interactions with the following proteins: Q9ER30 (Sarcosin), P09527 (Rab-7), O88960 (N-ethylmaleimide sensitive), P09456 (PKA I regulatory subunit), P27881 (Hexokinase type II), P07872 (Acyl-coenzyme A oxidase), Q6DGF1 (Isocitrate dehydrogenase), Q9EQX9 (Ubiquitin-conjugating), Q63446 (Polyubiquitin), P24268 (Cathepsin D), Q91XW0 (Heat shock protein 86), Q5FVH0 (unknown), P58405 (Striatin 3), Q62667 (Major vault protein), Q66H50 (unknown), Q09167 (splicing factor), Q9JHU5 (Arfaptin 1)."|comment:"Insulin increased GLUT4 interaction with the following proteins:Q9Z1P2 (R-actinin-1), P45592 (Cofilin), Q9QXQ0 (R-actinin-4), P26473 (ADP-ribosylation factor), P26437 (ADP-ribosylation factor),   Q7TNP1 (Basigin 2), Q6P6R2 (Dihydrolipoamide dehydrogenase),   P04797 (GAPDH), Q63081 (Protein disulfide isomerase), P29457 (47 kDa heat shock protein), Q9R1J8 (Leprecan), O88638 (Putative eps protein),   Q64375 (Synaptonemal complex)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:NDPK - Interactions involving proteins containing InterPro domain IPR001564, Nucleoside diphosphate kinase, core.	taxid:10116(rat-l6)|taxid:10116(Rattus norvegicus)	-	2006/02/15	2021/11/30	rogid:PbFY2lfrty8yw40Jq7ShR7xfuV410116	rogid:XFSQuVQN6D2YQ2pEVhaQUYmKE/410116	intact-crc:44F3A2176D02515F|rigid:9RVm0UBcqQF4k06RGKO89Bg16Q8	false	myc tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P19357	uniprotkb:P62870	intact:EBI-915426|uniprotkb:P97900|ensembl:ENSRNOP00000023256	intact:EBI-918620|uniprotkb:Q63529|uniprotkb:Q80W20|ensembl:ENSRNOP00000072621	psi-mi:glut4_rat(display_long)|uniprotkb:Glucose transporter type 4, insulin-responsive(gene name synonym)|uniprotkb:Slc2a4(gene name)|psi-mi:Slc2a4(display_short)|uniprotkb:Glut4(gene name synonym)	psi-mi:elob_rat(display_long)|uniprotkb:Elob(gene name)|psi-mi:Elob(display_short)|uniprotkb:Elongin 18 kDa subunit(gene name synonym)|uniprotkb:RNA polymerase II transcription factor SIII subunit B(gene name synonym)|uniprotkb:SIII p18(gene name synonym)|uniprotkb:Tceb2(gene name synonym)|uniprotkb:Transcription elongation factor B polypeptide 2(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Foster et al. (2006)	pubmed:16396496|mint:MINT-5218203	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-921030	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2711|refseq:NP_036883.1|refseq:XP_006246658.1|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007611"(learning or memory)|go:"GO:0007614"(short-term memory)|go:"GO:0007616"(long-term memory)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010021"(amylopectin biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031550"(positive regulation of brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044381"(glucose import in response to insulin stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046323"(glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0098694"(regulation of synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0098793"(presynapse)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002441("Glucose transporter, type 4 (GLUT4)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-189200|ensembl:ENSRNOG00000017226(gene)|ensembl:ENSRNOT00000023256(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)	rgd:621200|refseq:NP_112391.1|ensembl:ENSRNOG00000004814(gene)|ensembl:ENSRNOT00000087768(transcript)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0006368"(transcription elongation from RNA polymerase II promoter)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0030891"(VCB complex)|go:"GO:0031462"(Cul2-RING ubiquitin ligase complex)|go:"GO:0031466"(Cul5-RING ubiquitin ligase complex)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0070449"(elongin complex)|interpro:IPR000626(Ubiquitin)|interpro:IPR029071|interpro:IPR039049|mint:P62870|reactome:R-RNO-112382|reactome:R-RNO-1234176|reactome:R-RNO-674695|reactome:R-RNO-6796648|reactome:R-RNO-75955|reactome:R-RNO-8951664|reactome:R-RNO-9705462|reactome:R-RNO-983168	-	-	-	caution:"The participant EBI-349571(P68370) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919386(Q7TP47) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920972(Q5XIP9) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-916419(P11980) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919578(Q8R491) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920554(Q5U3Z7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920647(Q5U2X8) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920585(Q7TP24) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-779677(P05426) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-915744(P02454) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|agonist:Insulin was shown to increase or decrease GLUT4 protein interactions in specific cases.|comment:"Insulin decreased GLUT4 interactions with the following proteins: Q9ER30 (Sarcosin), P09527 (Rab-7), O88960 (N-ethylmaleimide sensitive), P09456 (PKA I regulatory subunit), P27881 (Hexokinase type II), P07872 (Acyl-coenzyme A oxidase), Q6DGF1 (Isocitrate dehydrogenase), Q9EQX9 (Ubiquitin-conjugating), Q63446 (Polyubiquitin), P24268 (Cathepsin D), Q91XW0 (Heat shock protein 86), Q5FVH0 (unknown), P58405 (Striatin 3), Q62667 (Major vault protein), Q66H50 (unknown), Q09167 (splicing factor), Q9JHU5 (Arfaptin 1)."|comment:"Insulin increased GLUT4 interaction with the following proteins:Q9Z1P2 (R-actinin-1), P45592 (Cofilin), Q9QXQ0 (R-actinin-4), P26473 (ADP-ribosylation factor), P26437 (ADP-ribosylation factor),   Q7TNP1 (Basigin 2), Q6P6R2 (Dihydrolipoamide dehydrogenase),   P04797 (GAPDH), Q63081 (Protein disulfide isomerase), P29457 (47 kDa heat shock protein), Q9R1J8 (Leprecan), O88638 (Putative eps protein),   Q64375 (Synaptonemal complex)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:NDPK - Interactions involving proteins containing InterPro domain IPR001564, Nucleoside diphosphate kinase, core.	taxid:10116(rat-l6)|taxid:10116(Rattus norvegicus)	-	2006/02/15	2021/11/30	rogid:PbFY2lfrty8yw40Jq7ShR7xfuV410116	rogid:7W4I9AcvS1GK89dMmBOImMYNgLY10116	intact-crc:44F3A2176D02515F|rigid:9RVm0UBcqQF4k06RGKO89Bg16Q8	false	myc tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P19357	uniprotkb:Q9QZM5	intact:EBI-915426|uniprotkb:P97900|ensembl:ENSRNOP00000023256	intact:EBI-920097|ensembl:ENSRNOP00000071079	psi-mi:glut4_rat(display_long)|uniprotkb:Glucose transporter type 4, insulin-responsive(gene name synonym)|uniprotkb:Slc2a4(gene name)|psi-mi:Slc2a4(display_short)|uniprotkb:Glut4(gene name synonym)	psi-mi:abi1_rat(display_long)|uniprotkb:Abi1(gene name)|psi-mi:Abi1(display_short)|uniprotkb:Abelson interactor 1(gene name synonym)|uniprotkb:Eps8 SH3 domain-binding protein(gene name synonym)|uniprotkb:e3B1(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Foster et al. (2006)	pubmed:16396496|mint:MINT-5218203	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-921030	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2711|refseq:NP_036883.1|refseq:XP_006246658.1|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007611"(learning or memory)|go:"GO:0007614"(short-term memory)|go:"GO:0007616"(long-term memory)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010021"(amylopectin biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031550"(positive regulation of brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044381"(glucose import in response to insulin stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046323"(glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0098694"(regulation of synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0098793"(presynapse)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002441("Glucose transporter, type 4 (GLUT4)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-189200|ensembl:ENSRNOG00000017226(gene)|ensembl:ENSRNOT00000023256(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)	rgd:621008|refseq:XP_006254416.1|dip:DIP-36968N|ensembl:ENSRNOG00000031325(gene)|ensembl:ENSRNOT00000091023(transcript)|go:"GO:0001756"(somitogenesis)|go:"GO:0005634"(nucleus)|go:"GO:0005856"(cytoskeleton)|go:"GO:0008154"(actin polymerization or depolymerization)|go:"GO:0014069"(postsynaptic density)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0030027"(lamellipodium)|go:"GO:0030296"(protein tyrosine kinase activator activity)|go:"GO:0030426"(growth cone)|go:"GO:0031209"(SCAR complex)|go:"GO:0031252"(cell leading edge)|go:"GO:0032433"(filopodium tip)|go:"GO:0035591"(signaling adaptor activity)|go:"GO:0035855"(megakaryocyte development)|go:"GO:0043005"(neuron projection)|go:"GO:0048813"(dendrite morphogenesis)|go:"GO:0072673"(lamellipodium morphogenesis)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099527"(postsynapse to nucleus signaling pathway)|interpro:IPR000727(Target SNARE coiled-coil region)|interpro:IPR001452(Src homology-3)|interpro:IPR012849(Abl-interactor, homeo-domain homologous region)|interpro:IPR028456|interpro:IPR028457|interpro:IPR035725|interpro:IPR036028|mint:Q9QZM5|reactome:R-RNO-2029482|reactome:R-RNO-4420097|reactome:R-RNO-5663213|reactome:R-RNO-9013149|reactome:R-RNO-9013404|reactome:R-RNO-9013423	-	-	-	caution:"The participant EBI-349571(P68370) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919386(Q7TP47) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920972(Q5XIP9) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-916419(P11980) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919578(Q8R491) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920554(Q5U3Z7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920647(Q5U2X8) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920585(Q7TP24) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-779677(P05426) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-915744(P02454) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|agonist:Insulin was shown to increase or decrease GLUT4 protein interactions in specific cases.|comment:"Insulin decreased GLUT4 interactions with the following proteins: Q9ER30 (Sarcosin), P09527 (Rab-7), O88960 (N-ethylmaleimide sensitive), P09456 (PKA I regulatory subunit), P27881 (Hexokinase type II), P07872 (Acyl-coenzyme A oxidase), Q6DGF1 (Isocitrate dehydrogenase), Q9EQX9 (Ubiquitin-conjugating), Q63446 (Polyubiquitin), P24268 (Cathepsin D), Q91XW0 (Heat shock protein 86), Q5FVH0 (unknown), P58405 (Striatin 3), Q62667 (Major vault protein), Q66H50 (unknown), Q09167 (splicing factor), Q9JHU5 (Arfaptin 1)."|comment:"Insulin increased GLUT4 interaction with the following proteins:Q9Z1P2 (R-actinin-1), P45592 (Cofilin), Q9QXQ0 (R-actinin-4), P26473 (ADP-ribosylation factor), P26437 (ADP-ribosylation factor),   Q7TNP1 (Basigin 2), Q6P6R2 (Dihydrolipoamide dehydrogenase),   P04797 (GAPDH), Q63081 (Protein disulfide isomerase), P29457 (47 kDa heat shock protein), Q9R1J8 (Leprecan), O88638 (Putative eps protein),   Q64375 (Synaptonemal complex)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:NDPK - Interactions involving proteins containing InterPro domain IPR001564, Nucleoside diphosphate kinase, core.	taxid:10116(rat-l6)|taxid:10116(Rattus norvegicus)	-	2006/02/15	2021/11/30	rogid:PbFY2lfrty8yw40Jq7ShR7xfuV410116	rogid:CjsnJsS1Qxx1udsrO+knqWLXKkc10116	intact-crc:44F3A2176D02515F|rigid:9RVm0UBcqQF4k06RGKO89Bg16Q8	false	myc tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P19357	uniprotkb:G3V6H1	intact:EBI-915426|uniprotkb:P97900|ensembl:ENSRNOP00000023256	intact:EBI-920793|uniprotkb:Q5YKG1|ensembl:ENSRNOP00000005015	psi-mi:glut4_rat(display_long)|uniprotkb:Glucose transporter type 4, insulin-responsive(gene name synonym)|uniprotkb:Slc2a4(gene name)|psi-mi:Slc2a4(display_short)|uniprotkb:Glut4(gene name synonym)	psi-mi:g3v6h1_rat(display_long)|uniprotkb:Galc(gene name)|psi-mi:Galc(display_short)|uniprotkb:Galactosylceramidase(gene name synonym)|uniprotkb:rCG_20789(orf name)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Foster et al. (2006)	pubmed:16396496|mint:MINT-5218203	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-921030	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2711|refseq:NP_036883.1|refseq:XP_006246658.1|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007611"(learning or memory)|go:"GO:0007614"(short-term memory)|go:"GO:0007616"(long-term memory)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010021"(amylopectin biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031550"(positive regulation of brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044381"(glucose import in response to insulin stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046323"(glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0098694"(regulation of synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0098793"(presynapse)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002441("Glucose transporter, type 4 (GLUT4)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-189200|ensembl:ENSRNOG00000017226(gene)|ensembl:ENSRNOT00000023256(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)	rgd:1359384|ensembl:ENSRNOG00000003759(gene)|ensembl:ENSRNOT00000005015(transcript)|go:"GO:0004336"(galactosylceramidase activity)|go:"GO:0005764"(lysosome)|go:"GO:0006683"(galactosylceramide catabolic process)|go:"GO:0042552"(myelination)|interpro:IPR001286(Glycoside hydrolase, family 59)|interpro:IPR013785(Aldolase-type TIM barrel)|interpro:IPR017853(Glycoside hydrolase, catalytic core)|interpro:IPR035394|reactome:R-RNO-1660662	-	-	-	caution:"The participant EBI-349571(P68370) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919386(Q7TP47) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920972(Q5XIP9) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-916419(P11980) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919578(Q8R491) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920554(Q5U3Z7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920647(Q5U2X8) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920585(Q7TP24) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-779677(P05426) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-915744(P02454) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|agonist:Insulin was shown to increase or decrease GLUT4 protein interactions in specific cases.|comment:"Insulin decreased GLUT4 interactions with the following proteins: Q9ER30 (Sarcosin), P09527 (Rab-7), O88960 (N-ethylmaleimide sensitive), P09456 (PKA I regulatory subunit), P27881 (Hexokinase type II), P07872 (Acyl-coenzyme A oxidase), Q6DGF1 (Isocitrate dehydrogenase), Q9EQX9 (Ubiquitin-conjugating), Q63446 (Polyubiquitin), P24268 (Cathepsin D), Q91XW0 (Heat shock protein 86), Q5FVH0 (unknown), P58405 (Striatin 3), Q62667 (Major vault protein), Q66H50 (unknown), Q09167 (splicing factor), Q9JHU5 (Arfaptin 1)."|comment:"Insulin increased GLUT4 interaction with the following proteins:Q9Z1P2 (R-actinin-1), P45592 (Cofilin), Q9QXQ0 (R-actinin-4), P26473 (ADP-ribosylation factor), P26437 (ADP-ribosylation factor),   Q7TNP1 (Basigin 2), Q6P6R2 (Dihydrolipoamide dehydrogenase),   P04797 (GAPDH), Q63081 (Protein disulfide isomerase), P29457 (47 kDa heat shock protein), Q9R1J8 (Leprecan), O88638 (Putative eps protein),   Q64375 (Synaptonemal complex)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:NDPK - Interactions involving proteins containing InterPro domain IPR001564, Nucleoside diphosphate kinase, core.	taxid:10116(rat-l6)|taxid:10116(Rattus norvegicus)	-	2006/02/15	2021/11/30	rogid:PbFY2lfrty8yw40Jq7ShR7xfuV410116	rogid:gD83Vtmu67iswUzAs04CmtDzA/010116	intact-crc:44F3A2176D02515F|rigid:9RVm0UBcqQF4k06RGKO89Bg16Q8	false	myc tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P19357	uniprotkb:Q5FWT1	intact:EBI-915426|uniprotkb:P97900|ensembl:ENSRNOP00000023256	intact:EBI-920789|ensembl:ENSRNOP00000042004	psi-mi:glut4_rat(display_long)|uniprotkb:Glucose transporter type 4, insulin-responsive(gene name synonym)|uniprotkb:Slc2a4(gene name)|psi-mi:Slc2a4(display_short)|uniprotkb:Glut4(gene name synonym)	psi-mi:fa98a_rat(display_long)|uniprotkb:Fam98a(gene name)|psi-mi:Fam98a(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Foster et al. (2006)	pubmed:16396496|mint:MINT-5218203	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-921030	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2711|refseq:NP_036883.1|refseq:XP_006246658.1|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007611"(learning or memory)|go:"GO:0007614"(short-term memory)|go:"GO:0007616"(long-term memory)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010021"(amylopectin biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031550"(positive regulation of brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044381"(glucose import in response to insulin stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046323"(glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0098694"(regulation of synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0098793"(presynapse)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002441("Glucose transporter, type 4 (GLUT4)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-189200|ensembl:ENSRNOG00000017226(gene)|ensembl:ENSRNOT00000023256(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)	rgd:1305486|refseq:NP_001014095.1|ensembl:ENSRNOG00000030328(gene)|ensembl:ENSRNOT00000052131(transcript)|go:"GO:0006479"(protein methylation)|go:"GO:0008276"(protein methyltransferase activity)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0032418"(lysosome localization)|go:"GO:0072669"(tRNA-splicing ligase complex)|go:"GO:1900029"(positive regulation of ruffle assembly)|interpro:IPR018797|mint:Q5FWT1	-	-	-	caution:"The participant EBI-349571(P68370) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919386(Q7TP47) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920972(Q5XIP9) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-916419(P11980) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919578(Q8R491) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920554(Q5U3Z7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920647(Q5U2X8) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920585(Q7TP24) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-779677(P05426) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-915744(P02454) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|agonist:Insulin was shown to increase or decrease GLUT4 protein interactions in specific cases.|comment:"Insulin decreased GLUT4 interactions with the following proteins: Q9ER30 (Sarcosin), P09527 (Rab-7), O88960 (N-ethylmaleimide sensitive), P09456 (PKA I regulatory subunit), P27881 (Hexokinase type II), P07872 (Acyl-coenzyme A oxidase), Q6DGF1 (Isocitrate dehydrogenase), Q9EQX9 (Ubiquitin-conjugating), Q63446 (Polyubiquitin), P24268 (Cathepsin D), Q91XW0 (Heat shock protein 86), Q5FVH0 (unknown), P58405 (Striatin 3), Q62667 (Major vault protein), Q66H50 (unknown), Q09167 (splicing factor), Q9JHU5 (Arfaptin 1)."|comment:"Insulin increased GLUT4 interaction with the following proteins:Q9Z1P2 (R-actinin-1), P45592 (Cofilin), Q9QXQ0 (R-actinin-4), P26473 (ADP-ribosylation factor), P26437 (ADP-ribosylation factor),   Q7TNP1 (Basigin 2), Q6P6R2 (Dihydrolipoamide dehydrogenase),   P04797 (GAPDH), Q63081 (Protein disulfide isomerase), P29457 (47 kDa heat shock protein), Q9R1J8 (Leprecan), O88638 (Putative eps protein),   Q64375 (Synaptonemal complex)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:NDPK - Interactions involving proteins containing InterPro domain IPR001564, Nucleoside diphosphate kinase, core.	taxid:10116(rat-l6)|taxid:10116(Rattus norvegicus)	-	2006/02/15	2021/11/30	rogid:PbFY2lfrty8yw40Jq7ShR7xfuV410116	rogid:4cL2E54a+iywa7RlPa4l8iroPa810116	intact-crc:44F3A2176D02515F|rigid:9RVm0UBcqQF4k06RGKO89Bg16Q8	false	myc tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P19357	uniprotkb:Q5XI43	intact:EBI-915426|uniprotkb:P97900|ensembl:ENSRNOP00000023256	intact:EBI-920780|ensembl:ENSRNOP00000058800	psi-mi:glut4_rat(display_long)|uniprotkb:Glucose transporter type 4, insulin-responsive(gene name synonym)|uniprotkb:Slc2a4(gene name)|psi-mi:Slc2a4(display_short)|uniprotkb:Glut4(gene name synonym)	psi-mi:mxra8_rat(display_long)|uniprotkb:Mxra8(gene name)|psi-mi:Mxra8(display_short)|uniprotkb:Limitrin(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Foster et al. (2006)	pubmed:16396496|mint:MINT-5218203	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-921030	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2711|refseq:NP_036883.1|refseq:XP_006246658.1|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007611"(learning or memory)|go:"GO:0007614"(short-term memory)|go:"GO:0007616"(long-term memory)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010021"(amylopectin biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031550"(positive regulation of brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044381"(glucose import in response to insulin stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046323"(glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0098694"(regulation of synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0098793"(presynapse)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002441("Glucose transporter, type 4 (GLUT4)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-189200|ensembl:ENSRNOG00000017226(gene)|ensembl:ENSRNOT00000023256(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)	rgd:1359356|refseq:NP_001007003.1|ensembl:ENSRNOG00000019244(gene)|ensembl:ENSRNOT00000067252(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0007155"(cell adhesion)|go:"GO:0009986"(cell surface)|go:"GO:0016021"(integral component of membrane)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060857"(establishment of glial blood-brain barrier)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|interpro:IPR042472|reactome:R-RNO-381426|reactome:R-RNO-8957275	-	-	-	caution:"The participant EBI-349571(P68370) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919386(Q7TP47) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920972(Q5XIP9) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-916419(P11980) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919578(Q8R491) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920554(Q5U3Z7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920647(Q5U2X8) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920585(Q7TP24) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-779677(P05426) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-915744(P02454) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|agonist:Insulin was shown to increase or decrease GLUT4 protein interactions in specific cases.|comment:"Insulin decreased GLUT4 interactions with the following proteins: Q9ER30 (Sarcosin), P09527 (Rab-7), O88960 (N-ethylmaleimide sensitive), P09456 (PKA I regulatory subunit), P27881 (Hexokinase type II), P07872 (Acyl-coenzyme A oxidase), Q6DGF1 (Isocitrate dehydrogenase), Q9EQX9 (Ubiquitin-conjugating), Q63446 (Polyubiquitin), P24268 (Cathepsin D), Q91XW0 (Heat shock protein 86), Q5FVH0 (unknown), P58405 (Striatin 3), Q62667 (Major vault protein), Q66H50 (unknown), Q09167 (splicing factor), Q9JHU5 (Arfaptin 1)."|comment:"Insulin increased GLUT4 interaction with the following proteins:Q9Z1P2 (R-actinin-1), P45592 (Cofilin), Q9QXQ0 (R-actinin-4), P26473 (ADP-ribosylation factor), P26437 (ADP-ribosylation factor),   Q7TNP1 (Basigin 2), Q6P6R2 (Dihydrolipoamide dehydrogenase),   P04797 (GAPDH), Q63081 (Protein disulfide isomerase), P29457 (47 kDa heat shock protein), Q9R1J8 (Leprecan), O88638 (Putative eps protein),   Q64375 (Synaptonemal complex)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:NDPK - Interactions involving proteins containing InterPro domain IPR001564, Nucleoside diphosphate kinase, core.	taxid:10116(rat-l6)|taxid:10116(Rattus norvegicus)	-	2006/02/15	2021/11/30	rogid:PbFY2lfrty8yw40Jq7ShR7xfuV410116	rogid:ziePM3KWLYiEMug+s1eYTRL3hDw10116	intact-crc:44F3A2176D02515F|rigid:9RVm0UBcqQF4k06RGKO89Bg16Q8	false	myc tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P19357	uniprotkb:Q5U2V8	intact:EBI-915426|uniprotkb:P97900|ensembl:ENSRNOP00000023256	intact:EBI-920775|ensembl:ENSRNOP00000013488	psi-mi:glut4_rat(display_long)|uniprotkb:Glucose transporter type 4, insulin-responsive(gene name synonym)|uniprotkb:Slc2a4(gene name)|psi-mi:Slc2a4(display_short)|uniprotkb:Glut4(gene name synonym)	psi-mi:emc3_rat(display_long)|uniprotkb:Emc3(gene name)|psi-mi:Emc3(display_short)|uniprotkb:Tmem111(gene name synonym)|uniprotkb:Transmembrane protein 111(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Foster et al. (2006)	pubmed:16396496|mint:MINT-5218203	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-921030	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2711|refseq:NP_036883.1|refseq:XP_006246658.1|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007611"(learning or memory)|go:"GO:0007614"(short-term memory)|go:"GO:0007616"(long-term memory)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010021"(amylopectin biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031550"(positive regulation of brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044381"(glucose import in response to insulin stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046323"(glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0098694"(regulation of synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0098793"(presynapse)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002441("Glucose transporter, type 4 (GLUT4)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-189200|ensembl:ENSRNOG00000017226(gene)|ensembl:ENSRNOT00000023256(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)	rgd:1311566|refseq:NP_001008356.1|ensembl:ENSRNOG00000009934(gene)|ensembl:ENSRNOT00000013488(transcript)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030176"(integral component of endoplasmic reticulum membrane)|go:"GO:0032977"(membrane insertase activity)|go:"GO:0045050"(protein insertion into ER membrane by stop-transfer membrane-anchor sequence)|go:"GO:0071816"(tail-anchored membrane protein insertion into ER membrane)|go:"GO:0072546"(EMC complex)|interpro:IPR002809(Protein of unknown function DUF106, transmembrane)|interpro:IPR008568(Protein of unknown function DUF850, transmembrane eukaryotic)|reactome:R-RNO-8980692	-	-	-	caution:"The participant EBI-349571(P68370) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919386(Q7TP47) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920972(Q5XIP9) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-916419(P11980) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919578(Q8R491) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920554(Q5U3Z7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920647(Q5U2X8) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920585(Q7TP24) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-779677(P05426) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-915744(P02454) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|agonist:Insulin was shown to increase or decrease GLUT4 protein interactions in specific cases.|comment:"Insulin decreased GLUT4 interactions with the following proteins: Q9ER30 (Sarcosin), P09527 (Rab-7), O88960 (N-ethylmaleimide sensitive), P09456 (PKA I regulatory subunit), P27881 (Hexokinase type II), P07872 (Acyl-coenzyme A oxidase), Q6DGF1 (Isocitrate dehydrogenase), Q9EQX9 (Ubiquitin-conjugating), Q63446 (Polyubiquitin), P24268 (Cathepsin D), Q91XW0 (Heat shock protein 86), Q5FVH0 (unknown), P58405 (Striatin 3), Q62667 (Major vault protein), Q66H50 (unknown), Q09167 (splicing factor), Q9JHU5 (Arfaptin 1)."|comment:"Insulin increased GLUT4 interaction with the following proteins:Q9Z1P2 (R-actinin-1), P45592 (Cofilin), Q9QXQ0 (R-actinin-4), P26473 (ADP-ribosylation factor), P26437 (ADP-ribosylation factor),   Q7TNP1 (Basigin 2), Q6P6R2 (Dihydrolipoamide dehydrogenase),   P04797 (GAPDH), Q63081 (Protein disulfide isomerase), P29457 (47 kDa heat shock protein), Q9R1J8 (Leprecan), O88638 (Putative eps protein),   Q64375 (Synaptonemal complex)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:NDPK - Interactions involving proteins containing InterPro domain IPR001564, Nucleoside diphosphate kinase, core.	taxid:10116(rat-l6)|taxid:10116(Rattus norvegicus)	-	2006/02/15	2021/11/30	rogid:PbFY2lfrty8yw40Jq7ShR7xfuV410116	rogid:ztXiJFIXq8R5eNjM6gVS5UL4Rsc10116	intact-crc:44F3A2176D02515F|rigid:9RVm0UBcqQF4k06RGKO89Bg16Q8	false	myc tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P19357	uniprotkb:Q4KM74	intact:EBI-915426|uniprotkb:P97900|ensembl:ENSRNOP00000023256	intact:EBI-920764|ensembl:ENSRNOP00000025327	psi-mi:glut4_rat(display_long)|uniprotkb:Glucose transporter type 4, insulin-responsive(gene name synonym)|uniprotkb:Slc2a4(gene name)|psi-mi:Slc2a4(display_short)|uniprotkb:Glut4(gene name synonym)	psi-mi:sc22b_rat(display_long)|uniprotkb:Sec22b(gene name)|psi-mi:Sec22b(display_short)|uniprotkb:SEC22 vesicle-trafficking protein homolog B(gene name synonym)|uniprotkb:SEC22 vesicle-trafficking protein-like 1(gene name synonym)|uniprotkb:ER-Golgi SNARE of 24 kDa(gene name synonym)|uniprotkb:Sec22l1(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Foster et al. (2006)	pubmed:16396496|mint:MINT-5218203	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-921030	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2711|refseq:NP_036883.1|refseq:XP_006246658.1|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007611"(learning or memory)|go:"GO:0007614"(short-term memory)|go:"GO:0007616"(long-term memory)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010021"(amylopectin biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031550"(positive regulation of brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044381"(glucose import in response to insulin stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046323"(glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0098694"(regulation of synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0098793"(presynapse)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002441("Glucose transporter, type 4 (GLUT4)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-189200|ensembl:ENSRNOG00000017226(gene)|ensembl:ENSRNOT00000023256(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)	rgd:1309988|refseq:NP_001020857.1|ensembl:ENSRNOG00000018673(gene)|ensembl:ENSRNOT00000025327(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0005484"(SNAP receptor activity)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005793"(endoplasmic reticulum-Golgi intermediate compartment)|go:"GO:0006888"(endoplasmic reticulum to Golgi vesicle-mediated transport)|go:"GO:0006890"(retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0012507"(ER to Golgi transport vesicle membrane)|go:"GO:0015031"(protein transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0019905"(syntaxin binding)|go:"GO:0030137"(COPI-coated vesicle)|go:"GO:0031201"(SNARE complex)|go:"GO:0033116"(endoplasmic reticulum-Golgi intermediate compartment membrane)|go:"GO:0042470"(melanosome)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0048280"(vesicle fusion with Golgi apparatus)|go:"GO:1902902"(negative regulation of autophagosome assembly)|interpro:IPR001388(Synaptobrevin)|interpro:IPR010908(Longin)|interpro:IPR011012(Longin-like)|interpro:IPR042855|interpro:IPR044565|reactome:R-RNO-1236974|reactome:R-RNO-204005|reactome:R-RNO-5694530|reactome:R-RNO-6811434	-	-	-	caution:"The participant EBI-349571(P68370) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919386(Q7TP47) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920972(Q5XIP9) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-916419(P11980) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919578(Q8R491) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920554(Q5U3Z7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920647(Q5U2X8) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920585(Q7TP24) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-779677(P05426) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-915744(P02454) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|agonist:Insulin was shown to increase or decrease GLUT4 protein interactions in specific cases.|comment:"Insulin decreased GLUT4 interactions with the following proteins: Q9ER30 (Sarcosin), P09527 (Rab-7), O88960 (N-ethylmaleimide sensitive), P09456 (PKA I regulatory subunit), P27881 (Hexokinase type II), P07872 (Acyl-coenzyme A oxidase), Q6DGF1 (Isocitrate dehydrogenase), Q9EQX9 (Ubiquitin-conjugating), Q63446 (Polyubiquitin), P24268 (Cathepsin D), Q91XW0 (Heat shock protein 86), Q5FVH0 (unknown), P58405 (Striatin 3), Q62667 (Major vault protein), Q66H50 (unknown), Q09167 (splicing factor), Q9JHU5 (Arfaptin 1)."|comment:"Insulin increased GLUT4 interaction with the following proteins:Q9Z1P2 (R-actinin-1), P45592 (Cofilin), Q9QXQ0 (R-actinin-4), P26473 (ADP-ribosylation factor), P26437 (ADP-ribosylation factor),   Q7TNP1 (Basigin 2), Q6P6R2 (Dihydrolipoamide dehydrogenase),   P04797 (GAPDH), Q63081 (Protein disulfide isomerase), P29457 (47 kDa heat shock protein), Q9R1J8 (Leprecan), O88638 (Putative eps protein),   Q64375 (Synaptonemal complex)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:NDPK - Interactions involving proteins containing InterPro domain IPR001564, Nucleoside diphosphate kinase, core.	taxid:10116(rat-l6)|taxid:10116(Rattus norvegicus)	-	2006/02/15	2021/11/30	rogid:PbFY2lfrty8yw40Jq7ShR7xfuV410116	rogid:DRKtD169T9eYZ2kFufLapidvcKs10116	intact-crc:44F3A2176D02515F|rigid:9RVm0UBcqQF4k06RGKO89Bg16Q8	false	myc tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P19357	uniprotkb:Q5BJK8	intact:EBI-915426|uniprotkb:P97900|ensembl:ENSRNOP00000023256	intact:EBI-920760|ensembl:ENSRNOP00000035176	psi-mi:glut4_rat(display_long)|uniprotkb:Glucose transporter type 4, insulin-responsive(gene name synonym)|uniprotkb:Slc2a4(gene name)|psi-mi:Slc2a4(display_short)|uniprotkb:Glut4(gene name synonym)	psi-mi:goli4_rat(display_long)|uniprotkb:Golim4(gene name)|psi-mi:Golim4(display_short)|uniprotkb:Golgi phosphoprotein 4(gene name synonym)|uniprotkb:Golgi integral membrane protein, cis(gene name synonym)|uniprotkb:Gimpc(gene name synonym)|uniprotkb:Golph4(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Foster et al. (2006)	pubmed:16396496|mint:MINT-5218203	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-921030	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2711|refseq:NP_036883.1|refseq:XP_006246658.1|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007611"(learning or memory)|go:"GO:0007614"(short-term memory)|go:"GO:0007616"(long-term memory)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010021"(amylopectin biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031550"(positive regulation of brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044381"(glucose import in response to insulin stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046323"(glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0098694"(regulation of synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0098793"(presynapse)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002441("Glucose transporter, type 4 (GLUT4)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-189200|ensembl:ENSRNOG00000017226(gene)|ensembl:ENSRNOT00000023256(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)	rgd:1310948|refseq:XP_006232562.1|ensembl:ENSRNOG00000024213(gene)|ensembl:ENSRNOT00000037115(transcript)|go:"GO:0010008"(endosome membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0032580"(Golgi cisterna membrane)|interpro:IPR042336	-	-	-	caution:"The participant EBI-349571(P68370) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919386(Q7TP47) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920972(Q5XIP9) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-916419(P11980) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919578(Q8R491) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920554(Q5U3Z7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920647(Q5U2X8) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920585(Q7TP24) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-779677(P05426) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-915744(P02454) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|agonist:Insulin was shown to increase or decrease GLUT4 protein interactions in specific cases.|comment:"Insulin decreased GLUT4 interactions with the following proteins: Q9ER30 (Sarcosin), P09527 (Rab-7), O88960 (N-ethylmaleimide sensitive), P09456 (PKA I regulatory subunit), P27881 (Hexokinase type II), P07872 (Acyl-coenzyme A oxidase), Q6DGF1 (Isocitrate dehydrogenase), Q9EQX9 (Ubiquitin-conjugating), Q63446 (Polyubiquitin), P24268 (Cathepsin D), Q91XW0 (Heat shock protein 86), Q5FVH0 (unknown), P58405 (Striatin 3), Q62667 (Major vault protein), Q66H50 (unknown), Q09167 (splicing factor), Q9JHU5 (Arfaptin 1)."|comment:"Insulin increased GLUT4 interaction with the following proteins:Q9Z1P2 (R-actinin-1), P45592 (Cofilin), Q9QXQ0 (R-actinin-4), P26473 (ADP-ribosylation factor), P26437 (ADP-ribosylation factor),   Q7TNP1 (Basigin 2), Q6P6R2 (Dihydrolipoamide dehydrogenase),   P04797 (GAPDH), Q63081 (Protein disulfide isomerase), P29457 (47 kDa heat shock protein), Q9R1J8 (Leprecan), O88638 (Putative eps protein),   Q64375 (Synaptonemal complex)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:NDPK - Interactions involving proteins containing InterPro domain IPR001564, Nucleoside diphosphate kinase, core.	taxid:10116(rat-l6)|taxid:10116(Rattus norvegicus)	-	2006/02/15	2021/11/30	rogid:PbFY2lfrty8yw40Jq7ShR7xfuV410116	rogid:B1yNyWAPPXt3fKfD8G0sVF3Pocs10116	intact-crc:44F3A2176D02515F|rigid:9RVm0UBcqQF4k06RGKO89Bg16Q8	false	myc tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P19357	uniprotkb:Q5U302	intact:EBI-915426|uniprotkb:P97900|ensembl:ENSRNOP00000023256	intact:EBI-920749|ensembl:ENSRNOP00000008041	psi-mi:glut4_rat(display_long)|uniprotkb:Glucose transporter type 4, insulin-responsive(gene name synonym)|uniprotkb:Slc2a4(gene name)|psi-mi:Slc2a4(display_short)|uniprotkb:Glut4(gene name synonym)	psi-mi:q5u302_rat(display_long)|uniprotkb:Ctnna1(gene name)|psi-mi:Ctnna1(display_short)|uniprotkb:Catna1(gene name synonym)|uniprotkb:rCG_49560(orf name)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Foster et al. (2006)	pubmed:16396496|mint:MINT-5218203	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-921030	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2711|refseq:NP_036883.1|refseq:XP_006246658.1|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007611"(learning or memory)|go:"GO:0007614"(short-term memory)|go:"GO:0007616"(long-term memory)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010021"(amylopectin biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031550"(positive regulation of brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044381"(glucose import in response to insulin stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046323"(glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0098694"(regulation of synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0098793"(presynapse)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002441("Glucose transporter, type 4 (GLUT4)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-189200|ensembl:ENSRNOG00000017226(gene)|ensembl:ENSRNOT00000023256(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)	rgd:1359485|refseq:NP_001007146.1|ensembl:ENSRNOG00000005796(gene)|ensembl:ENSRNOT00000008041(transcript)|go:"GO:0001541"(ovarian follicle development)|go:"GO:0001669"(acrosomal vesicle)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005912"(adherens junction)|go:"GO:0005915"(zonula adherens)|go:"GO:0007015"(actin filament organization)|go:"GO:0007163"(establishment or maintenance of cell polarity)|go:"GO:0007406"(negative regulation of neuroblast proliferation)|go:"GO:0007568"(aging)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008584"(male gonad development)|go:"GO:0014070"(response to organic cyclic compound)|go:"GO:0014704"(intercalated disc)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016264"(gap junction assembly)|go:"GO:0016342"(catenin complex)|go:"GO:0016477"(cell migration)|go:"GO:0016600"(flotillin complex)|go:"GO:0017166"(vinculin binding)|go:"GO:0030027"(lamellipodium)|go:"GO:0031103"(axon regeneration)|go:"GO:0034613"(cellular protein localization)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042475"(odontogenesis of dentin-containing tooth)|go:"GO:0042802"(identical protein binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043297"(apical junction assembly)|go:"GO:0043627"(response to estrogen)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045295"(gamma-catenin binding)|go:"GO:0045296"(cadherin binding)|go:"GO:0045880"(positive regulation of smoothened signaling pathway)|go:"GO:0051015"(actin filament binding)|go:"GO:0071681"(cellular response to indole-3-methanol)|go:"GO:0090136"(epithelial cell-cell adhesion)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:1900181"(negative regulation of protein localization to nucleus)|go:"GO:2000146"(negative regulation of cell motility)|go:"GO:2001045"(negative regulation of integrin-mediated signaling pathway)|go:"GO:2001240"(negative regulation of extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:2001241"(positive regulation of extrinsic apoptotic signaling pathway in absence of ligand)|interpro:IPR000633(Vinculin, conserved site)|interpro:IPR001033(Alpha-catenin)|interpro:IPR006077(Vinculin/alpha-catenin)|interpro:IPR030047|interpro:IPR036723|reactome:R-RNO-418990|reactome:R-RNO-5218920|reactome:R-RNO-525793|reactome:R-RNO-5626467|refseq:XP_017456453.1	-	-	-	caution:"The participant EBI-349571(P68370) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919386(Q7TP47) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920972(Q5XIP9) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-916419(P11980) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919578(Q8R491) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920554(Q5U3Z7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920647(Q5U2X8) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920585(Q7TP24) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-779677(P05426) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-915744(P02454) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|agonist:Insulin was shown to increase or decrease GLUT4 protein interactions in specific cases.|comment:"Insulin decreased GLUT4 interactions with the following proteins: Q9ER30 (Sarcosin), P09527 (Rab-7), O88960 (N-ethylmaleimide sensitive), P09456 (PKA I regulatory subunit), P27881 (Hexokinase type II), P07872 (Acyl-coenzyme A oxidase), Q6DGF1 (Isocitrate dehydrogenase), Q9EQX9 (Ubiquitin-conjugating), Q63446 (Polyubiquitin), P24268 (Cathepsin D), Q91XW0 (Heat shock protein 86), Q5FVH0 (unknown), P58405 (Striatin 3), Q62667 (Major vault protein), Q66H50 (unknown), Q09167 (splicing factor), Q9JHU5 (Arfaptin 1)."|comment:"Insulin increased GLUT4 interaction with the following proteins:Q9Z1P2 (R-actinin-1), P45592 (Cofilin), Q9QXQ0 (R-actinin-4), P26473 (ADP-ribosylation factor), P26437 (ADP-ribosylation factor),   Q7TNP1 (Basigin 2), Q6P6R2 (Dihydrolipoamide dehydrogenase),   P04797 (GAPDH), Q63081 (Protein disulfide isomerase), P29457 (47 kDa heat shock protein), Q9R1J8 (Leprecan), O88638 (Putative eps protein),   Q64375 (Synaptonemal complex)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:NDPK - Interactions involving proteins containing InterPro domain IPR001564, Nucleoside diphosphate kinase, core.	taxid:10116(rat-l6)|taxid:10116(Rattus norvegicus)	-	2006/02/15	2021/11/30	rogid:PbFY2lfrty8yw40Jq7ShR7xfuV410116	rogid:wB/6HwVE3/evEF7MZz8pBhRbrDU10116	intact-crc:44F3A2176D02515F|rigid:9RVm0UBcqQF4k06RGKO89Bg16Q8	false	myc tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P19357	uniprotkb:Q4QQV0	intact:EBI-915426|uniprotkb:P97900|ensembl:ENSRNOP00000023256	intact:EBI-920733|ensembl:ENSRNOP00000024947	psi-mi:glut4_rat(display_long)|uniprotkb:Glucose transporter type 4, insulin-responsive(gene name synonym)|uniprotkb:Slc2a4(gene name)|psi-mi:Slc2a4(display_short)|uniprotkb:Glut4(gene name synonym)	psi-mi:q4qqv0_rat(display_long)|uniprotkb:Tubb6(gene name)|psi-mi:Tubb6(display_short)|uniprotkb:rCG_46689(orf name)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Foster et al. (2006)	pubmed:16396496|mint:MINT-5218203	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-921030	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2711|refseq:NP_036883.1|refseq:XP_006246658.1|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007611"(learning or memory)|go:"GO:0007614"(short-term memory)|go:"GO:0007616"(long-term memory)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010021"(amylopectin biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031550"(positive regulation of brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044381"(glucose import in response to insulin stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046323"(glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0098694"(regulation of synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0098793"(presynapse)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002441("Glucose transporter, type 4 (GLUT4)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-189200|ensembl:ENSRNOG00000017226(gene)|ensembl:ENSRNOT00000023256(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)	rgd:1305887|refseq:NP_001020846.1|reactome:R-RNO-68877|reactome:R-RNO-8852276|reactome:R-RNO-8955332|reactome:R-RNO-9646399|reactome:R-RNO-9648025|reactome:R-RNO-9668328|reactome:R-RNO-983189|ensembl:ENSRNOG00000018371(gene)|ensembl:ENSRNOT00000024947(transcript)|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0003924"(GTPase activity)|go:"GO:0005200"(structural constituent of cytoskeleton)|go:"GO:0005525"(GTP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005874"(microtubule)|interpro:IPR000217(Tubulin)|interpro:IPR002453(Beta tubulin)|interpro:IPR003008(Tubulin/FtsZ, GTPase)|interpro:IPR008280(Tubulin/FtsZ, C-terminal)|interpro:IPR013838(Beta tubulin, autoregulation binding site)|interpro:IPR017975|interpro:IPR018316|interpro:IPR023123|interpro:IPR036525|interpro:IPR037103|reactome:R-RNO-190840|reactome:R-RNO-2132295|reactome:R-RNO-2467813|reactome:R-RNO-2500257|reactome:R-RNO-3371497|reactome:R-RNO-380320|reactome:R-RNO-437239|reactome:R-RNO-5610787|reactome:R-RNO-5617833|reactome:R-RNO-5620924|reactome:R-RNO-5626467|reactome:R-RNO-5663220|reactome:R-RNO-6807878|reactome:R-RNO-6811434|reactome:R-RNO-6811436	-	-	-	caution:"The participant EBI-349571(P68370) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919386(Q7TP47) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920972(Q5XIP9) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-916419(P11980) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919578(Q8R491) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920554(Q5U3Z7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920647(Q5U2X8) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920585(Q7TP24) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-779677(P05426) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-915744(P02454) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|agonist:Insulin was shown to increase or decrease GLUT4 protein interactions in specific cases.|comment:"Insulin decreased GLUT4 interactions with the following proteins: Q9ER30 (Sarcosin), P09527 (Rab-7), O88960 (N-ethylmaleimide sensitive), P09456 (PKA I regulatory subunit), P27881 (Hexokinase type II), P07872 (Acyl-coenzyme A oxidase), Q6DGF1 (Isocitrate dehydrogenase), Q9EQX9 (Ubiquitin-conjugating), Q63446 (Polyubiquitin), P24268 (Cathepsin D), Q91XW0 (Heat shock protein 86), Q5FVH0 (unknown), P58405 (Striatin 3), Q62667 (Major vault protein), Q66H50 (unknown), Q09167 (splicing factor), Q9JHU5 (Arfaptin 1)."|comment:"Insulin increased GLUT4 interaction with the following proteins:Q9Z1P2 (R-actinin-1), P45592 (Cofilin), Q9QXQ0 (R-actinin-4), P26473 (ADP-ribosylation factor), P26437 (ADP-ribosylation factor),   Q7TNP1 (Basigin 2), Q6P6R2 (Dihydrolipoamide dehydrogenase),   P04797 (GAPDH), Q63081 (Protein disulfide isomerase), P29457 (47 kDa heat shock protein), Q9R1J8 (Leprecan), O88638 (Putative eps protein),   Q64375 (Synaptonemal complex)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:NDPK - Interactions involving proteins containing InterPro domain IPR001564, Nucleoside diphosphate kinase, core.	taxid:10116(rat-l6)|taxid:10116(Rattus norvegicus)	-	2006/02/15	2021/11/30	rogid:PbFY2lfrty8yw40Jq7ShR7xfuV410116	rogid:nhJ4Ma3BRCPGCML+eci2KGGB7zc10116	intact-crc:44F3A2176D02515F|rigid:9RVm0UBcqQF4k06RGKO89Bg16Q8	false	myc tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P19357	uniprotkb:Q5EB77	intact:EBI-915426|uniprotkb:P97900|ensembl:ENSRNOP00000023256	intact:EBI-920726|ensembl:ENSRNOP00000025828	psi-mi:glut4_rat(display_long)|uniprotkb:Glucose transporter type 4, insulin-responsive(gene name synonym)|uniprotkb:Slc2a4(gene name)|psi-mi:Slc2a4(display_short)|uniprotkb:Glut4(gene name synonym)	psi-mi:rab18_rat(display_long)|uniprotkb:Rab18(gene name)|psi-mi:Rab18(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Foster et al. (2006)	pubmed:16396496|mint:MINT-5218203	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-921030	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2711|refseq:NP_036883.1|refseq:XP_006246658.1|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007611"(learning or memory)|go:"GO:0007614"(short-term memory)|go:"GO:0007616"(long-term memory)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010021"(amylopectin biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031550"(positive regulation of brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044381"(glucose import in response to insulin stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046323"(glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0098694"(regulation of synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0098793"(presynapse)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002441("Glucose transporter, type 4 (GLUT4)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-189200|ensembl:ENSRNOG00000017226(gene)|ensembl:ENSRNOT00000023256(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)	rgd:1308905|refseq:NP_001012486.1|ensembl:ENSRNOG00000018972(gene)|ensembl:ENSRNOT00000025828(transcript)|go:"GO:0001654"(eye development)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005811"(lipid droplet)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0007420"(brain development)|go:"GO:0012505"(endomembrane system)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019003"(GDP binding)|go:"GO:0034389"(lipid droplet organization)|go:"GO:0045202"(synapse)|go:"GO:0051170"(import into nucleus)|go:"GO:0071782"(endoplasmic reticulum tubular network)|go:"GO:0071786"(endoplasmic reticulum tubular network organization)|interpro:IPR001806(Ras GTPase)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR025662|interpro:IPR027417|reactome:R-RNO-6798695|reactome:R-RNO-6811436|reactome:R-RNO-8873719|reactome:R-RNO-8876198	-	-	-	caution:"The participant EBI-349571(P68370) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919386(Q7TP47) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920972(Q5XIP9) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-916419(P11980) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919578(Q8R491) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920554(Q5U3Z7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920647(Q5U2X8) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920585(Q7TP24) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-779677(P05426) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-915744(P02454) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|agonist:Insulin was shown to increase or decrease GLUT4 protein interactions in specific cases.|comment:"Insulin decreased GLUT4 interactions with the following proteins: Q9ER30 (Sarcosin), P09527 (Rab-7), O88960 (N-ethylmaleimide sensitive), P09456 (PKA I regulatory subunit), P27881 (Hexokinase type II), P07872 (Acyl-coenzyme A oxidase), Q6DGF1 (Isocitrate dehydrogenase), Q9EQX9 (Ubiquitin-conjugating), Q63446 (Polyubiquitin), P24268 (Cathepsin D), Q91XW0 (Heat shock protein 86), Q5FVH0 (unknown), P58405 (Striatin 3), Q62667 (Major vault protein), Q66H50 (unknown), Q09167 (splicing factor), Q9JHU5 (Arfaptin 1)."|comment:"Insulin increased GLUT4 interaction with the following proteins:Q9Z1P2 (R-actinin-1), P45592 (Cofilin), Q9QXQ0 (R-actinin-4), P26473 (ADP-ribosylation factor), P26437 (ADP-ribosylation factor),   Q7TNP1 (Basigin 2), Q6P6R2 (Dihydrolipoamide dehydrogenase),   P04797 (GAPDH), Q63081 (Protein disulfide isomerase), P29457 (47 kDa heat shock protein), Q9R1J8 (Leprecan), O88638 (Putative eps protein),   Q64375 (Synaptonemal complex)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:NDPK - Interactions involving proteins containing InterPro domain IPR001564, Nucleoside diphosphate kinase, core.	taxid:10116(rat-l6)|taxid:10116(Rattus norvegicus)	-	2006/02/15	2021/11/30	rogid:PbFY2lfrty8yw40Jq7ShR7xfuV410116	rogid:ilsm3brCq3OY2KfR6wpWlQkQxno10116	intact-crc:44F3A2176D02515F|rigid:9RVm0UBcqQF4k06RGKO89Bg16Q8	false	myc tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P19357	uniprotkb:Q5XII0	intact:EBI-915426|uniprotkb:P97900|ensembl:ENSRNOP00000023256	intact:EBI-920718|ensembl:ENSRNOP00000073174	psi-mi:glut4_rat(display_long)|uniprotkb:Glucose transporter type 4, insulin-responsive(gene name synonym)|uniprotkb:Slc2a4(gene name)|psi-mi:Slc2a4(display_short)|uniprotkb:Glut4(gene name synonym)	psi-mi:epdr1_rat(display_long)|uniprotkb:Epdr1(gene name)|psi-mi:Epdr1(display_short)|uniprotkb:Epdr2(gene name synonym)|uniprotkb:Merp1(gene name synonym)|uniprotkb:Merp2(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Foster et al. (2006)	pubmed:16396496|mint:MINT-5218203	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-921030	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2711|refseq:NP_036883.1|refseq:XP_006246658.1|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007611"(learning or memory)|go:"GO:0007614"(short-term memory)|go:"GO:0007616"(long-term memory)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010021"(amylopectin biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031550"(positive regulation of brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044381"(glucose import in response to insulin stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046323"(glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0098694"(regulation of synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0098793"(presynapse)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002441("Glucose transporter, type 4 (GLUT4)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-189200|ensembl:ENSRNOG00000017226(gene)|ensembl:ENSRNOT00000023256(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)	rgd:1359161|refseq:NP_001007626.1|ensembl:ENSRNOG00000060141(gene)|ensembl:ENSRNOT00000085923(transcript)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005764"(lysosome)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0042802"(identical protein binding)|go:"GO:0043202"(lysosomal lumen)|go:"GO:1905573"(ganglioside GM1 binding)|go:"GO:1990764"(myofibroblast contraction)|interpro:IPR001299(Ependymin)	-	-	-	caution:"The participant EBI-349571(P68370) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919386(Q7TP47) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920972(Q5XIP9) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-916419(P11980) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919578(Q8R491) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920554(Q5U3Z7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920647(Q5U2X8) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920585(Q7TP24) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-779677(P05426) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-915744(P02454) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|agonist:Insulin was shown to increase or decrease GLUT4 protein interactions in specific cases.|comment:"Insulin decreased GLUT4 interactions with the following proteins: Q9ER30 (Sarcosin), P09527 (Rab-7), O88960 (N-ethylmaleimide sensitive), P09456 (PKA I regulatory subunit), P27881 (Hexokinase type II), P07872 (Acyl-coenzyme A oxidase), Q6DGF1 (Isocitrate dehydrogenase), Q9EQX9 (Ubiquitin-conjugating), Q63446 (Polyubiquitin), P24268 (Cathepsin D), Q91XW0 (Heat shock protein 86), Q5FVH0 (unknown), P58405 (Striatin 3), Q62667 (Major vault protein), Q66H50 (unknown), Q09167 (splicing factor), Q9JHU5 (Arfaptin 1)."|comment:"Insulin increased GLUT4 interaction with the following proteins:Q9Z1P2 (R-actinin-1), P45592 (Cofilin), Q9QXQ0 (R-actinin-4), P26473 (ADP-ribosylation factor), P26437 (ADP-ribosylation factor),   Q7TNP1 (Basigin 2), Q6P6R2 (Dihydrolipoamide dehydrogenase),   P04797 (GAPDH), Q63081 (Protein disulfide isomerase), P29457 (47 kDa heat shock protein), Q9R1J8 (Leprecan), O88638 (Putative eps protein),   Q64375 (Synaptonemal complex)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:NDPK - Interactions involving proteins containing InterPro domain IPR001564, Nucleoside diphosphate kinase, core.	taxid:10116(rat-l6)|taxid:10116(Rattus norvegicus)	-	2006/02/15	2021/11/30	rogid:PbFY2lfrty8yw40Jq7ShR7xfuV410116	rogid:dr9UFouaGKIltPijAJR7cdi7hpw10116	intact-crc:44F3A2176D02515F|rigid:9RVm0UBcqQF4k06RGKO89Bg16Q8	false	myc tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P19357	uniprotkb:Q5XID6	intact:EBI-915426|uniprotkb:P97900|ensembl:ENSRNOP00000023256	intact:EBI-920710|ensembl:ENSRNOP00000019639	psi-mi:glut4_rat(display_long)|uniprotkb:Glucose transporter type 4, insulin-responsive(gene name synonym)|uniprotkb:Slc2a4(gene name)|psi-mi:Slc2a4(display_short)|uniprotkb:Glut4(gene name synonym)	psi-mi:q5xid6_rat(display_long)|uniprotkb:Sgcg(gene name)|psi-mi:Sgcg(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Foster et al. (2006)	pubmed:16396496|mint:MINT-5218203	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-921030	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2711|refseq:NP_036883.1|refseq:XP_006246658.1|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007611"(learning or memory)|go:"GO:0007614"(short-term memory)|go:"GO:0007616"(long-term memory)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010021"(amylopectin biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031550"(positive regulation of brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044381"(glucose import in response to insulin stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046323"(glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0098694"(regulation of synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0098793"(presynapse)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002441("Glucose transporter, type 4 (GLUT4)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-189200|ensembl:ENSRNOG00000017226(gene)|ensembl:ENSRNOT00000023256(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)	rgd:1359577|refseq:NP_001006994.1|go:"GO:0048738"(cardiac muscle tissue development)|go:"GO:0060047"(heart contraction)|interpro:IPR006875(Sarcoglycan complex subunit protein)|interpro:IPR027660|interpro:IPR039972|ensembl:ENSRNOG00000014603(gene)|ensembl:ENSRNOT00000019639(transcript)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0016011"(dystroglycan complex)|go:"GO:0016012"(sarcoglycan complex)|go:"GO:0016021"(integral component of membrane)|go:"GO:0042383"(sarcolemma)	-	-	-	caution:"The participant EBI-349571(P68370) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919386(Q7TP47) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920972(Q5XIP9) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-916419(P11980) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919578(Q8R491) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920554(Q5U3Z7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920647(Q5U2X8) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920585(Q7TP24) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-779677(P05426) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-915744(P02454) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|agonist:Insulin was shown to increase or decrease GLUT4 protein interactions in specific cases.|comment:"Insulin decreased GLUT4 interactions with the following proteins: Q9ER30 (Sarcosin), P09527 (Rab-7), O88960 (N-ethylmaleimide sensitive), P09456 (PKA I regulatory subunit), P27881 (Hexokinase type II), P07872 (Acyl-coenzyme A oxidase), Q6DGF1 (Isocitrate dehydrogenase), Q9EQX9 (Ubiquitin-conjugating), Q63446 (Polyubiquitin), P24268 (Cathepsin D), Q91XW0 (Heat shock protein 86), Q5FVH0 (unknown), P58405 (Striatin 3), Q62667 (Major vault protein), Q66H50 (unknown), Q09167 (splicing factor), Q9JHU5 (Arfaptin 1)."|comment:"Insulin increased GLUT4 interaction with the following proteins:Q9Z1P2 (R-actinin-1), P45592 (Cofilin), Q9QXQ0 (R-actinin-4), P26473 (ADP-ribosylation factor), P26437 (ADP-ribosylation factor),   Q7TNP1 (Basigin 2), Q6P6R2 (Dihydrolipoamide dehydrogenase),   P04797 (GAPDH), Q63081 (Protein disulfide isomerase), P29457 (47 kDa heat shock protein), Q9R1J8 (Leprecan), O88638 (Putative eps protein),   Q64375 (Synaptonemal complex)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:NDPK - Interactions involving proteins containing InterPro domain IPR001564, Nucleoside diphosphate kinase, core.	taxid:10116(rat-l6)|taxid:10116(Rattus norvegicus)	-	2006/02/15	2021/11/30	rogid:PbFY2lfrty8yw40Jq7ShR7xfuV410116	rogid:eSsp3ha/Sjf7eWIFrtuA+bJM5T010116	intact-crc:44F3A2176D02515F|rigid:9RVm0UBcqQF4k06RGKO89Bg16Q8	false	myc tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P19357	uniprotkb:Q3B7V5	intact:EBI-915426|uniprotkb:P97900|ensembl:ENSRNOP00000023256	intact:EBI-920701|ensembl:ENSRNOP00000057211	psi-mi:glut4_rat(display_long)|uniprotkb:Glucose transporter type 4, insulin-responsive(gene name synonym)|uniprotkb:Slc2a4(gene name)|psi-mi:Slc2a4(display_short)|uniprotkb:Glut4(gene name synonym)	psi-mi:q3b7v5_rat(display_long)|uniprotkb:Rab2b(gene name)|psi-mi:Rab2b(display_short)|uniprotkb:rCG_61209(orf name)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Foster et al. (2006)	pubmed:16396496|mint:MINT-5218203	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-921030	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2711|refseq:NP_036883.1|refseq:XP_006246658.1|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007611"(learning or memory)|go:"GO:0007614"(short-term memory)|go:"GO:0007616"(long-term memory)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010021"(amylopectin biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031550"(positive regulation of brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044381"(glucose import in response to insulin stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046323"(glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0098694"(regulation of synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0098793"(presynapse)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002441("Glucose transporter, type 4 (GLUT4)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-189200|ensembl:ENSRNOG00000017226(gene)|ensembl:ENSRNOT00000023256(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)	refseq:NP_001032734.1|rgd:1309117|ensembl:ENSRNOG00000012488(gene)|ensembl:ENSRNOT00000060467(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0045921"(positive regulation of exocytosis)|go:"GO:0098793"(presynapse)|interpro:IPR001806(Ras GTPase)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR027417|reactome:R-RNO-8873719	-	-	-	caution:"The participant EBI-349571(P68370) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919386(Q7TP47) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920972(Q5XIP9) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-916419(P11980) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919578(Q8R491) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920554(Q5U3Z7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920647(Q5U2X8) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920585(Q7TP24) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-779677(P05426) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-915744(P02454) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|agonist:Insulin was shown to increase or decrease GLUT4 protein interactions in specific cases.|comment:"Insulin decreased GLUT4 interactions with the following proteins: Q9ER30 (Sarcosin), P09527 (Rab-7), O88960 (N-ethylmaleimide sensitive), P09456 (PKA I regulatory subunit), P27881 (Hexokinase type II), P07872 (Acyl-coenzyme A oxidase), Q6DGF1 (Isocitrate dehydrogenase), Q9EQX9 (Ubiquitin-conjugating), Q63446 (Polyubiquitin), P24268 (Cathepsin D), Q91XW0 (Heat shock protein 86), Q5FVH0 (unknown), P58405 (Striatin 3), Q62667 (Major vault protein), Q66H50 (unknown), Q09167 (splicing factor), Q9JHU5 (Arfaptin 1)."|comment:"Insulin increased GLUT4 interaction with the following proteins:Q9Z1P2 (R-actinin-1), P45592 (Cofilin), Q9QXQ0 (R-actinin-4), P26473 (ADP-ribosylation factor), P26437 (ADP-ribosylation factor),   Q7TNP1 (Basigin 2), Q6P6R2 (Dihydrolipoamide dehydrogenase),   P04797 (GAPDH), Q63081 (Protein disulfide isomerase), P29457 (47 kDa heat shock protein), Q9R1J8 (Leprecan), O88638 (Putative eps protein),   Q64375 (Synaptonemal complex)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:NDPK - Interactions involving proteins containing InterPro domain IPR001564, Nucleoside diphosphate kinase, core.	taxid:10116(rat-l6)|taxid:10116(Rattus norvegicus)	-	2006/02/15	2021/11/30	rogid:PbFY2lfrty8yw40Jq7ShR7xfuV410116	rogid:ZRLc6ZLl4APkHMBIGkjN0XKl/TY10116	intact-crc:44F3A2176D02515F|rigid:9RVm0UBcqQF4k06RGKO89Bg16Q8	false	myc tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P19357	uniprotkb:Q5BJT7	intact:EBI-915426|uniprotkb:P97900|ensembl:ENSRNOP00000023256	intact:EBI-920697|ensembl:ENSRNOP00000003435	psi-mi:glut4_rat(display_long)|uniprotkb:Glucose transporter type 4, insulin-responsive(gene name synonym)|uniprotkb:Slc2a4(gene name)|psi-mi:Slc2a4(display_short)|uniprotkb:Glut4(gene name synonym)	psi-mi:ccd93_rat(display_long)|uniprotkb:Ccdc93(gene name)|psi-mi:Ccdc93(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Foster et al. (2006)	pubmed:16396496|mint:MINT-5218203	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-921030	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2711|refseq:NP_036883.1|refseq:XP_006246658.1|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007611"(learning or memory)|go:"GO:0007614"(short-term memory)|go:"GO:0007616"(long-term memory)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010021"(amylopectin biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031550"(positive regulation of brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044381"(glucose import in response to insulin stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046323"(glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0098694"(regulation of synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0098793"(presynapse)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002441("Glucose transporter, type 4 (GLUT4)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-189200|ensembl:ENSRNOG00000017226(gene)|ensembl:ENSRNOT00000023256(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)	rgd:1560504|refseq:NP_001020168.1|ensembl:ENSRNOG00000002514(gene)|ensembl:ENSRNOT00000003435(transcript)|go:"GO:0005769"(early endosome)|go:"GO:0006893"(Golgi to plasma membrane transport)|go:"GO:0015031"(protein transport)|go:"GO:0032456"(endocytic recycling)|interpro:IPR019159|interpro:IPR039116	-	-	-	caution:"The participant EBI-349571(P68370) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919386(Q7TP47) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920972(Q5XIP9) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-916419(P11980) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919578(Q8R491) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920554(Q5U3Z7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920647(Q5U2X8) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920585(Q7TP24) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-779677(P05426) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-915744(P02454) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|agonist:Insulin was shown to increase or decrease GLUT4 protein interactions in specific cases.|comment:"Insulin decreased GLUT4 interactions with the following proteins: Q9ER30 (Sarcosin), P09527 (Rab-7), O88960 (N-ethylmaleimide sensitive), P09456 (PKA I regulatory subunit), P27881 (Hexokinase type II), P07872 (Acyl-coenzyme A oxidase), Q6DGF1 (Isocitrate dehydrogenase), Q9EQX9 (Ubiquitin-conjugating), Q63446 (Polyubiquitin), P24268 (Cathepsin D), Q91XW0 (Heat shock protein 86), Q5FVH0 (unknown), P58405 (Striatin 3), Q62667 (Major vault protein), Q66H50 (unknown), Q09167 (splicing factor), Q9JHU5 (Arfaptin 1)."|comment:"Insulin increased GLUT4 interaction with the following proteins:Q9Z1P2 (R-actinin-1), P45592 (Cofilin), Q9QXQ0 (R-actinin-4), P26473 (ADP-ribosylation factor), P26437 (ADP-ribosylation factor),   Q7TNP1 (Basigin 2), Q6P6R2 (Dihydrolipoamide dehydrogenase),   P04797 (GAPDH), Q63081 (Protein disulfide isomerase), P29457 (47 kDa heat shock protein), Q9R1J8 (Leprecan), O88638 (Putative eps protein),   Q64375 (Synaptonemal complex)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:NDPK - Interactions involving proteins containing InterPro domain IPR001564, Nucleoside diphosphate kinase, core.	taxid:10116(rat-l6)|taxid:10116(Rattus norvegicus)	-	2006/02/15	2021/11/30	rogid:PbFY2lfrty8yw40Jq7ShR7xfuV410116	rogid:7RpqrRfAAcnlnfEI40eM6HWhdGs10116	intact-crc:44F3A2176D02515F|rigid:9RVm0UBcqQF4k06RGKO89Bg16Q8	false	myc tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P19357	uniprotkb:Q5FVQ4	intact:EBI-915426|uniprotkb:P97900|ensembl:ENSRNOP00000023256	intact:EBI-920693|ensembl:ENSRNOP00000035497	psi-mi:glut4_rat(display_long)|uniprotkb:Glucose transporter type 4, insulin-responsive(gene name synonym)|uniprotkb:Slc2a4(gene name)|psi-mi:Slc2a4(display_short)|uniprotkb:Glut4(gene name synonym)	psi-mi:mlec_rat(display_long)|uniprotkb:Mlec(gene name)|psi-mi:Mlec(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Foster et al. (2006)	pubmed:16396496|mint:MINT-5218203	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-921030	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2711|refseq:NP_036883.1|refseq:XP_006246658.1|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007611"(learning or memory)|go:"GO:0007614"(short-term memory)|go:"GO:0007616"(long-term memory)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010021"(amylopectin biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031550"(positive regulation of brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044381"(glucose import in response to insulin stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046323"(glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0098694"(regulation of synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0098793"(presynapse)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002441("Glucose transporter, type 4 (GLUT4)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-189200|ensembl:ENSRNOG00000017226(gene)|ensembl:ENSRNOT00000023256(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)	rgd:1307736|refseq:NP_001014005.1|ensembl:ENSRNOG00000021725(gene)|ensembl:ENSRNOT00000038395(transcript)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005975"(carbohydrate metabolic process)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019899"(enzyme binding)|go:"GO:0030246"(carbohydrate binding)|interpro:IPR021720|interpro:IPR039155|reactome:R-RNO-6798695	-	-	-	caution:"The participant EBI-349571(P68370) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919386(Q7TP47) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920972(Q5XIP9) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-916419(P11980) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919578(Q8R491) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920554(Q5U3Z7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920647(Q5U2X8) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920585(Q7TP24) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-779677(P05426) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-915744(P02454) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|agonist:Insulin was shown to increase or decrease GLUT4 protein interactions in specific cases.|comment:"Insulin decreased GLUT4 interactions with the following proteins: Q9ER30 (Sarcosin), P09527 (Rab-7), O88960 (N-ethylmaleimide sensitive), P09456 (PKA I regulatory subunit), P27881 (Hexokinase type II), P07872 (Acyl-coenzyme A oxidase), Q6DGF1 (Isocitrate dehydrogenase), Q9EQX9 (Ubiquitin-conjugating), Q63446 (Polyubiquitin), P24268 (Cathepsin D), Q91XW0 (Heat shock protein 86), Q5FVH0 (unknown), P58405 (Striatin 3), Q62667 (Major vault protein), Q66H50 (unknown), Q09167 (splicing factor), Q9JHU5 (Arfaptin 1)."|comment:"Insulin increased GLUT4 interaction with the following proteins:Q9Z1P2 (R-actinin-1), P45592 (Cofilin), Q9QXQ0 (R-actinin-4), P26473 (ADP-ribosylation factor), P26437 (ADP-ribosylation factor),   Q7TNP1 (Basigin 2), Q6P6R2 (Dihydrolipoamide dehydrogenase),   P04797 (GAPDH), Q63081 (Protein disulfide isomerase), P29457 (47 kDa heat shock protein), Q9R1J8 (Leprecan), O88638 (Putative eps protein),   Q64375 (Synaptonemal complex)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:NDPK - Interactions involving proteins containing InterPro domain IPR001564, Nucleoside diphosphate kinase, core.	taxid:10116(rat-l6)|taxid:10116(Rattus norvegicus)	-	2006/02/15	2021/11/30	rogid:PbFY2lfrty8yw40Jq7ShR7xfuV410116	rogid:788jrKDwAZ4o7gO9oIzd/Np20Wc10116	intact-crc:44F3A2176D02515F|rigid:9RVm0UBcqQF4k06RGKO89Bg16Q8	false	myc tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P19357	uniprotkb:Q4G061	intact:EBI-915426|uniprotkb:P97900|ensembl:ENSRNOP00000023256	intact:EBI-920686|ensembl:ENSRNOP00000057188	psi-mi:glut4_rat(display_long)|uniprotkb:Glucose transporter type 4, insulin-responsive(gene name synonym)|uniprotkb:Slc2a4(gene name)|psi-mi:Slc2a4(display_short)|uniprotkb:Glut4(gene name synonym)	psi-mi:eif3b_rat(display_long)|uniprotkb:Eif3b(gene name)|psi-mi:Eif3b(display_short)|uniprotkb:Eif3s9(gene name synonym)|uniprotkb:Eukaryotic translation initiation factor 3 subunit 9(gene name synonym)|uniprotkb:eIF-3-eta(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Foster et al. (2006)	pubmed:16396496|mint:MINT-5218203	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-921030	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2711|refseq:NP_036883.1|refseq:XP_006246658.1|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007611"(learning or memory)|go:"GO:0007614"(short-term memory)|go:"GO:0007616"(long-term memory)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010021"(amylopectin biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031550"(positive regulation of brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044381"(glucose import in response to insulin stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046323"(glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0098694"(regulation of synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0098793"(presynapse)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002441("Glucose transporter, type 4 (GLUT4)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-189200|ensembl:ENSRNOG00000017226(gene)|ensembl:ENSRNOT00000023256(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)	rgd:1309018|refseq:NP_001026810.1|ensembl:ENSRNOG00000001253(gene)|ensembl:ENSRNOT00000060444(transcript)|go:"GO:0001732"(formation of cytoplasmic translation initiation complex)|go:"GO:0003723"(RNA binding)|go:"GO:0003743"(translation initiation factor activity)|go:"GO:0005852"(eukaryotic translation initiation factor 3 complex)|go:"GO:0006413"(translational initiation)|go:"GO:0006446"(regulation of translational initiation)|go:"GO:0016282"(eukaryotic 43S preinitiation complex)|go:"GO:0031369"(translation initiation factor binding)|go:"GO:0033290"(eukaryotic 48S preinitiation complex)|go:"GO:0045202"(synapse)|go:"GO:0071541"(eukaryotic translation initiation factor 3 complex, eIF3m)|go:"GO:0075522"(IRES-dependent viral translational initiation)|go:"GO:0075525"(viral translational termination-reinitiation)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR011400(Translation initiation factor eIF-3b)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR013979(Eukaryotic translation initiation factor 2A, central region)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR034363|interpro:IPR035979|reactome:R-RNO-156827|reactome:R-RNO-72649|reactome:R-RNO-72689|reactome:R-RNO-72695|reactome:R-RNO-72702|reactome:R-RNO-72706	-	-	-	caution:"The participant EBI-349571(P68370) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919386(Q7TP47) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920972(Q5XIP9) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-916419(P11980) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919578(Q8R491) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920554(Q5U3Z7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920647(Q5U2X8) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920585(Q7TP24) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-779677(P05426) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-915744(P02454) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|agonist:Insulin was shown to increase or decrease GLUT4 protein interactions in specific cases.|comment:"Insulin decreased GLUT4 interactions with the following proteins: Q9ER30 (Sarcosin), P09527 (Rab-7), O88960 (N-ethylmaleimide sensitive), P09456 (PKA I regulatory subunit), P27881 (Hexokinase type II), P07872 (Acyl-coenzyme A oxidase), Q6DGF1 (Isocitrate dehydrogenase), Q9EQX9 (Ubiquitin-conjugating), Q63446 (Polyubiquitin), P24268 (Cathepsin D), Q91XW0 (Heat shock protein 86), Q5FVH0 (unknown), P58405 (Striatin 3), Q62667 (Major vault protein), Q66H50 (unknown), Q09167 (splicing factor), Q9JHU5 (Arfaptin 1)."|comment:"Insulin increased GLUT4 interaction with the following proteins:Q9Z1P2 (R-actinin-1), P45592 (Cofilin), Q9QXQ0 (R-actinin-4), P26473 (ADP-ribosylation factor), P26437 (ADP-ribosylation factor),   Q7TNP1 (Basigin 2), Q6P6R2 (Dihydrolipoamide dehydrogenase),   P04797 (GAPDH), Q63081 (Protein disulfide isomerase), P29457 (47 kDa heat shock protein), Q9R1J8 (Leprecan), O88638 (Putative eps protein),   Q64375 (Synaptonemal complex)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:NDPK - Interactions involving proteins containing InterPro domain IPR001564, Nucleoside diphosphate kinase, core.	taxid:10116(rat-l6)|taxid:10116(Rattus norvegicus)	-	2006/02/15	2021/11/30	rogid:PbFY2lfrty8yw40Jq7ShR7xfuV410116	rogid:ItyBKyq0XcsYU3nWcNjNFhpn/1Q10116	intact-crc:44F3A2176D02515F|rigid:9RVm0UBcqQF4k06RGKO89Bg16Q8	false	myc tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P19357	uniprotkb:Q5M843	intact:EBI-915426|uniprotkb:P97900|ensembl:ENSRNOP00000023256	intact:EBI-920679|ensembl:ENSRNOP00000051808	psi-mi:glut4_rat(display_long)|uniprotkb:Glucose transporter type 4, insulin-responsive(gene name synonym)|uniprotkb:Slc2a4(gene name)|psi-mi:Slc2a4(display_short)|uniprotkb:Glut4(gene name synonym)	psi-mi:ogfd3_rat(display_long)|uniprotkb:Ogfod3(gene name)|psi-mi:Ogfod3(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Foster et al. (2006)	pubmed:16396496|mint:MINT-5218203	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-921030	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2711|refseq:NP_036883.1|refseq:XP_006246658.1|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007611"(learning or memory)|go:"GO:0007614"(short-term memory)|go:"GO:0007616"(long-term memory)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010021"(amylopectin biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031550"(positive regulation of brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044381"(glucose import in response to insulin stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046323"(glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0098694"(regulation of synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0098793"(presynapse)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002441("Glucose transporter, type 4 (GLUT4)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-189200|ensembl:ENSRNOG00000017226(gene)|ensembl:ENSRNOT00000023256(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)	refseq:NP_001013998.1|rgd:1305007|ensembl:ENSRNOG00000036668(gene)|ensembl:ENSRNOT00000054925(transcript)|go:"GO:0005506"(iron ion binding)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016705"(oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen)|go:"GO:0031418"(L-ascorbic acid binding)|go:"GO:0051213"(dioxygenase activity)|interpro:IPR005123("2OG-Fe(II) oxygenase")|interpro:IPR006620(Prolyl 4-hydroxylase, alpha subunit)|interpro:IPR039210	-	-	-	caution:"The participant EBI-349571(P68370) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919386(Q7TP47) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920972(Q5XIP9) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-916419(P11980) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919578(Q8R491) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920554(Q5U3Z7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920647(Q5U2X8) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920585(Q7TP24) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-779677(P05426) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-915744(P02454) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|agonist:Insulin was shown to increase or decrease GLUT4 protein interactions in specific cases.|comment:"Insulin decreased GLUT4 interactions with the following proteins: Q9ER30 (Sarcosin), P09527 (Rab-7), O88960 (N-ethylmaleimide sensitive), P09456 (PKA I regulatory subunit), P27881 (Hexokinase type II), P07872 (Acyl-coenzyme A oxidase), Q6DGF1 (Isocitrate dehydrogenase), Q9EQX9 (Ubiquitin-conjugating), Q63446 (Polyubiquitin), P24268 (Cathepsin D), Q91XW0 (Heat shock protein 86), Q5FVH0 (unknown), P58405 (Striatin 3), Q62667 (Major vault protein), Q66H50 (unknown), Q09167 (splicing factor), Q9JHU5 (Arfaptin 1)."|comment:"Insulin increased GLUT4 interaction with the following proteins:Q9Z1P2 (R-actinin-1), P45592 (Cofilin), Q9QXQ0 (R-actinin-4), P26473 (ADP-ribosylation factor), P26437 (ADP-ribosylation factor),   Q7TNP1 (Basigin 2), Q6P6R2 (Dihydrolipoamide dehydrogenase),   P04797 (GAPDH), Q63081 (Protein disulfide isomerase), P29457 (47 kDa heat shock protein), Q9R1J8 (Leprecan), O88638 (Putative eps protein),   Q64375 (Synaptonemal complex)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:NDPK - Interactions involving proteins containing InterPro domain IPR001564, Nucleoside diphosphate kinase, core.	taxid:10116(rat-l6)|taxid:10116(Rattus norvegicus)	-	2006/02/15	2021/11/30	rogid:PbFY2lfrty8yw40Jq7ShR7xfuV410116	rogid:kA7uJj33gv9o8p3be1upqWExn2Q10116	intact-crc:44F3A2176D02515F|rigid:9RVm0UBcqQF4k06RGKO89Bg16Q8	false	myc tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P19357	uniprotkb:Q5XIQ4	intact:EBI-915426|uniprotkb:P97900|ensembl:ENSRNOP00000023256	intact:EBI-920669|ensembl:ENSRNOP00000004416	psi-mi:glut4_rat(display_long)|uniprotkb:Glucose transporter type 4, insulin-responsive(gene name synonym)|uniprotkb:Slc2a4(gene name)|psi-mi:Slc2a4(display_short)|uniprotkb:Glut4(gene name synonym)	psi-mi:mgrn1_rat(display_long)|uniprotkb:Mgrn1(gene name)|psi-mi:Mgrn1(display_short)|uniprotkb:Mahogunin RING finger protein 1(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase MGRN1(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Foster et al. (2006)	pubmed:16396496|mint:MINT-5218203	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-921030	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2711|refseq:NP_036883.1|refseq:XP_006246658.1|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007611"(learning or memory)|go:"GO:0007614"(short-term memory)|go:"GO:0007616"(long-term memory)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010021"(amylopectin biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031550"(positive regulation of brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044381"(glucose import in response to insulin stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046323"(glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0098694"(regulation of synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0098793"(presynapse)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002441("Glucose transporter, type 4 (GLUT4)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-189200|ensembl:ENSRNOG00000017226(gene)|ensembl:ENSRNOT00000023256(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)	rgd:1311862|refseq:NP_001013986.1|ensembl:ENSRNOG00000003234(gene)|ensembl:ENSRNOT00000004416(transcript)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005769"(early endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006513"(protein monoubiquitination)|go:"GO:0008333"(endosome to lysosome transport)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0043951"(negative regulation of cAMP-mediated signaling)|go:"GO:0045744"(negative regulation of G protein-coupled receptor signaling pathway)|go:"GO:0045879"(negative regulation of smoothened signaling pathway)|go:"GO:0046872"(metal ion binding)|go:"GO:0061630"(ubiquitin protein ligase activity)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|reactome:R-RNO-983168	-	-	-	caution:"The participant EBI-349571(P68370) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919386(Q7TP47) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920972(Q5XIP9) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-916419(P11980) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919578(Q8R491) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920554(Q5U3Z7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920647(Q5U2X8) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920585(Q7TP24) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-779677(P05426) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-915744(P02454) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|agonist:Insulin was shown to increase or decrease GLUT4 protein interactions in specific cases.|comment:"Insulin decreased GLUT4 interactions with the following proteins: Q9ER30 (Sarcosin), P09527 (Rab-7), O88960 (N-ethylmaleimide sensitive), P09456 (PKA I regulatory subunit), P27881 (Hexokinase type II), P07872 (Acyl-coenzyme A oxidase), Q6DGF1 (Isocitrate dehydrogenase), Q9EQX9 (Ubiquitin-conjugating), Q63446 (Polyubiquitin), P24268 (Cathepsin D), Q91XW0 (Heat shock protein 86), Q5FVH0 (unknown), P58405 (Striatin 3), Q62667 (Major vault protein), Q66H50 (unknown), Q09167 (splicing factor), Q9JHU5 (Arfaptin 1)."|comment:"Insulin increased GLUT4 interaction with the following proteins:Q9Z1P2 (R-actinin-1), P45592 (Cofilin), Q9QXQ0 (R-actinin-4), P26473 (ADP-ribosylation factor), P26437 (ADP-ribosylation factor),   Q7TNP1 (Basigin 2), Q6P6R2 (Dihydrolipoamide dehydrogenase),   P04797 (GAPDH), Q63081 (Protein disulfide isomerase), P29457 (47 kDa heat shock protein), Q9R1J8 (Leprecan), O88638 (Putative eps protein),   Q64375 (Synaptonemal complex)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:NDPK - Interactions involving proteins containing InterPro domain IPR001564, Nucleoside diphosphate kinase, core.	taxid:10116(rat-l6)|taxid:10116(Rattus norvegicus)	-	2006/02/15	2021/11/30	rogid:PbFY2lfrty8yw40Jq7ShR7xfuV410116	rogid:WdWNDqYQT/IRvWc2hWWEIyxM0lU10116	intact-crc:44F3A2176D02515F|rigid:9RVm0UBcqQF4k06RGKO89Bg16Q8	false	myc tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P19357	uniprotkb:D4A414	intact:EBI-915426|uniprotkb:P97900|ensembl:ENSRNOP00000023256	intact:EBI-920662|ensembl:ENSRNOP00000023215	psi-mi:glut4_rat(display_long)|uniprotkb:Glucose transporter type 4, insulin-responsive(gene name synonym)|uniprotkb:Slc2a4(gene name)|psi-mi:Slc2a4(display_short)|uniprotkb:Glut4(gene name synonym)	psi-mi:d4a414_rat(display_long)|uniprotkb:Cox15(gene name)|psi-mi:Cox15(display_short)|uniprotkb:LOC100911779(gene name synonym)|uniprotkb:rCG_57483(orf name)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Foster et al. (2006)	pubmed:16396496|mint:MINT-5218203	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-921030	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2711|refseq:NP_036883.1|refseq:XP_006246658.1|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007611"(learning or memory)|go:"GO:0007614"(short-term memory)|go:"GO:0007616"(long-term memory)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010021"(amylopectin biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031550"(positive regulation of brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044381"(glucose import in response to insulin stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046323"(glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0098694"(regulation of synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0098793"(presynapse)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002441("Glucose transporter, type 4 (GLUT4)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-189200|ensembl:ENSRNOG00000017226(gene)|ensembl:ENSRNOT00000023256(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)	refseq:NP_001028871.2|rgd:1312043|ensembl:ENSRNOG00000017230(gene)|ensembl:ENSRNOT00000023215(transcript)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0006784"(heme A biosynthetic process)|go:"GO:0008535"(respiratory chain complex IV assembly)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016653"("oxidoreductase activity, acting on NAD(P)H, heme protein as acceptor")|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0070069"(cytochrome complex)|go:"GO:1902600"(proton transmembrane transport)|interpro:IPR003780(Cytochrome oxidase assembly)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR023754|reactome:R-RNO-189451	-	-	-	caution:"The participant EBI-349571(P68370) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919386(Q7TP47) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920972(Q5XIP9) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-916419(P11980) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919578(Q8R491) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920554(Q5U3Z7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920647(Q5U2X8) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920585(Q7TP24) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-779677(P05426) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-915744(P02454) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|agonist:Insulin was shown to increase or decrease GLUT4 protein interactions in specific cases.|comment:"Insulin decreased GLUT4 interactions with the following proteins: Q9ER30 (Sarcosin), P09527 (Rab-7), O88960 (N-ethylmaleimide sensitive), P09456 (PKA I regulatory subunit), P27881 (Hexokinase type II), P07872 (Acyl-coenzyme A oxidase), Q6DGF1 (Isocitrate dehydrogenase), Q9EQX9 (Ubiquitin-conjugating), Q63446 (Polyubiquitin), P24268 (Cathepsin D), Q91XW0 (Heat shock protein 86), Q5FVH0 (unknown), P58405 (Striatin 3), Q62667 (Major vault protein), Q66H50 (unknown), Q09167 (splicing factor), Q9JHU5 (Arfaptin 1)."|comment:"Insulin increased GLUT4 interaction with the following proteins:Q9Z1P2 (R-actinin-1), P45592 (Cofilin), Q9QXQ0 (R-actinin-4), P26473 (ADP-ribosylation factor), P26437 (ADP-ribosylation factor),   Q7TNP1 (Basigin 2), Q6P6R2 (Dihydrolipoamide dehydrogenase),   P04797 (GAPDH), Q63081 (Protein disulfide isomerase), P29457 (47 kDa heat shock protein), Q9R1J8 (Leprecan), O88638 (Putative eps protein),   Q64375 (Synaptonemal complex)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:NDPK - Interactions involving proteins containing InterPro domain IPR001564, Nucleoside diphosphate kinase, core.	taxid:10116(rat-l6)|taxid:10116(Rattus norvegicus)	-	2006/02/15	2021/11/30	rogid:PbFY2lfrty8yw40Jq7ShR7xfuV410116	rogid:XP1QWIxPHbReuDrKDClSvgigjIQ10116	intact-crc:44F3A2176D02515F|rigid:9RVm0UBcqQF4k06RGKO89Bg16Q8	false	myc tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P19357	uniprotkb:Q5PQM3	intact:EBI-915426|uniprotkb:P97900|ensembl:ENSRNOP00000023256	intact:EBI-920657	psi-mi:glut4_rat(display_long)|uniprotkb:Glucose transporter type 4, insulin-responsive(gene name synonym)|uniprotkb:Slc2a4(gene name)|psi-mi:Slc2a4(display_short)|uniprotkb:Glut4(gene name synonym)	psi-mi:q5pqm3_rat(display_long)|uniprotkb:Ehbp1l1(gene name)|psi-mi:Ehbp1l1(display_short)|uniprotkb:LOC309169(gene name synonym)|uniprotkb:rCG_47454(orf name)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Foster et al. (2006)	pubmed:16396496|mint:MINT-5218203	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-921030	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2711|refseq:NP_036883.1|refseq:XP_006246658.1|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007611"(learning or memory)|go:"GO:0007614"(short-term memory)|go:"GO:0007616"(long-term memory)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010021"(amylopectin biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031550"(positive regulation of brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044381"(glucose import in response to insulin stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046323"(glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0098694"(regulation of synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0098793"(presynapse)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002441("Glucose transporter, type 4 (GLUT4)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-189200|ensembl:ENSRNOG00000017226(gene)|ensembl:ENSRNOT00000023256(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)	interpro:IPR001715(Calponin-like actin-binding)|interpro:IPR022735|rgd:1563823|interpro:IPR019448|refseq:NP_001257634.1|interpro:IPR029928|interpro:IPR036872	-	-	-	caution:"The participant EBI-349571(P68370) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919386(Q7TP47) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920972(Q5XIP9) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-916419(P11980) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919578(Q8R491) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920554(Q5U3Z7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920647(Q5U2X8) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920585(Q7TP24) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-779677(P05426) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-915744(P02454) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|agonist:Insulin was shown to increase or decrease GLUT4 protein interactions in specific cases.|comment:"Insulin decreased GLUT4 interactions with the following proteins: Q9ER30 (Sarcosin), P09527 (Rab-7), O88960 (N-ethylmaleimide sensitive), P09456 (PKA I regulatory subunit), P27881 (Hexokinase type II), P07872 (Acyl-coenzyme A oxidase), Q6DGF1 (Isocitrate dehydrogenase), Q9EQX9 (Ubiquitin-conjugating), Q63446 (Polyubiquitin), P24268 (Cathepsin D), Q91XW0 (Heat shock protein 86), Q5FVH0 (unknown), P58405 (Striatin 3), Q62667 (Major vault protein), Q66H50 (unknown), Q09167 (splicing factor), Q9JHU5 (Arfaptin 1)."|comment:"Insulin increased GLUT4 interaction with the following proteins:Q9Z1P2 (R-actinin-1), P45592 (Cofilin), Q9QXQ0 (R-actinin-4), P26473 (ADP-ribosylation factor), P26437 (ADP-ribosylation factor),   Q7TNP1 (Basigin 2), Q6P6R2 (Dihydrolipoamide dehydrogenase),   P04797 (GAPDH), Q63081 (Protein disulfide isomerase), P29457 (47 kDa heat shock protein), Q9R1J8 (Leprecan), O88638 (Putative eps protein),   Q64375 (Synaptonemal complex)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:NDPK - Interactions involving proteins containing InterPro domain IPR001564, Nucleoside diphosphate kinase, core.	taxid:10116(rat-l6)|taxid:10116(Rattus norvegicus)	-	2006/02/15	2021/11/30	rogid:PbFY2lfrty8yw40Jq7ShR7xfuV410116	rogid:tii7J3y1ypkQ9DHU5Q07k5C9Kgs10116	intact-crc:44F3A2176D02515F|rigid:9RVm0UBcqQF4k06RGKO89Bg16Q8	false	myc tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P19357	uniprotkb:Q32PX6	intact:EBI-915426|uniprotkb:P97900|ensembl:ENSRNOP00000023256	intact:EBI-920651|ensembl:ENSRNOP00000027641	psi-mi:glut4_rat(display_long)|uniprotkb:Glucose transporter type 4, insulin-responsive(gene name synonym)|uniprotkb:Slc2a4(gene name)|psi-mi:Slc2a4(display_short)|uniprotkb:Glut4(gene name synonym)	psi-mi:q32px6_rat(display_long)|uniprotkb:Rhog(gene name)|psi-mi:Rhog(display_short)|uniprotkb:rCG_39701(orf name)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Foster et al. (2006)	pubmed:16396496|mint:MINT-5218203	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-921030	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2711|refseq:NP_036883.1|refseq:XP_006246658.1|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007611"(learning or memory)|go:"GO:0007614"(short-term memory)|go:"GO:0007616"(long-term memory)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010021"(amylopectin biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031550"(positive regulation of brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044381"(glucose import in response to insulin stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046323"(glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0098694"(regulation of synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0098793"(presynapse)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002441("Glucose transporter, type 4 (GLUT4)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-189200|ensembl:ENSRNOG00000017226(gene)|ensembl:ENSRNOT00000023256(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)	rgd:621310|refseq:NP_001032272.1|refseq:XP_006229944.1|refseq:XP_006229945.1|ensembl:ENSRNOG00000020393(gene)|ensembl:ENSRNOT00000027641(transcript)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005938"(cell cortex)|go:"GO:0007015"(actin filament organization)|go:"GO:0007163"(establishment or maintenance of cell polarity)|go:"GO:0007266"(Rho protein signal transduction)|go:"GO:0008045"(motor neuron axon guidance)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0016601"(Rac protein signal transduction)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030031"(cell projection assembly)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030865"(cortical cytoskeleton organization)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0032956"(regulation of actin cytoskeleton organization)|go:"GO:0042995"(cell projection)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043652"(engulfment of apoptotic cell)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0090630"(activation of GTPase activity)|go:"GO:1900027"(regulation of ruffle assembly)|go:"GO:1902622"(regulation of neutrophil migration)|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|interpro:IPR001806(Ras GTPase)|interpro:IPR003578(Ras small GTPase, Rho type)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR027417|interpro:IPR042734|reactome:R-RNO-114604|reactome:R-RNO-1257604|reactome:R-RNO-5625970|reactome:R-RNO-6798695|reactome:R-RNO-6811558|reactome:R-RNO-9013408	-	-	-	caution:"The participant EBI-349571(P68370) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919386(Q7TP47) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920972(Q5XIP9) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-916419(P11980) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919578(Q8R491) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920554(Q5U3Z7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920647(Q5U2X8) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920585(Q7TP24) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-779677(P05426) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-915744(P02454) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|agonist:Insulin was shown to increase or decrease GLUT4 protein interactions in specific cases.|comment:"Insulin decreased GLUT4 interactions with the following proteins: Q9ER30 (Sarcosin), P09527 (Rab-7), O88960 (N-ethylmaleimide sensitive), P09456 (PKA I regulatory subunit), P27881 (Hexokinase type II), P07872 (Acyl-coenzyme A oxidase), Q6DGF1 (Isocitrate dehydrogenase), Q9EQX9 (Ubiquitin-conjugating), Q63446 (Polyubiquitin), P24268 (Cathepsin D), Q91XW0 (Heat shock protein 86), Q5FVH0 (unknown), P58405 (Striatin 3), Q62667 (Major vault protein), Q66H50 (unknown), Q09167 (splicing factor), Q9JHU5 (Arfaptin 1)."|comment:"Insulin increased GLUT4 interaction with the following proteins:Q9Z1P2 (R-actinin-1), P45592 (Cofilin), Q9QXQ0 (R-actinin-4), P26473 (ADP-ribosylation factor), P26437 (ADP-ribosylation factor),   Q7TNP1 (Basigin 2), Q6P6R2 (Dihydrolipoamide dehydrogenase),   P04797 (GAPDH), Q63081 (Protein disulfide isomerase), P29457 (47 kDa heat shock protein), Q9R1J8 (Leprecan), O88638 (Putative eps protein),   Q64375 (Synaptonemal complex)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:NDPK - Interactions involving proteins containing InterPro domain IPR001564, Nucleoside diphosphate kinase, core.	taxid:10116(rat-l6)|taxid:10116(Rattus norvegicus)	-	2006/02/15	2021/11/30	rogid:PbFY2lfrty8yw40Jq7ShR7xfuV410116	rogid:9PItVl1k5j6JhIDqwqcov1E/N8w10116	intact-crc:44F3A2176D02515F|rigid:9RVm0UBcqQF4k06RGKO89Bg16Q8	false	myc tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P19357	uniprotkb:Q5U2X8	intact:EBI-915426|uniprotkb:P97900|ensembl:ENSRNOP00000023256	intact:EBI-920647|ensembl:ENSRNOP00000005033	psi-mi:glut4_rat(display_long)|uniprotkb:Glucose transporter type 4, insulin-responsive(gene name synonym)|uniprotkb:Slc2a4(gene name)|psi-mi:Slc2a4(display_short)|uniprotkb:Glut4(gene name synonym)	psi-mi:q5u2x8_rat(display_long)|uniprotkb:Acot9(gene name)|psi-mi:Acot9(display_short)|uniprotkb:LOC302640(gene name synonym)|uniprotkb:rCG_36383(orf name)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Foster et al. (2006)	pubmed:16396496|mint:MINT-5218203	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-921030	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2711|refseq:NP_036883.1|refseq:XP_006246658.1|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007611"(learning or memory)|go:"GO:0007614"(short-term memory)|go:"GO:0007616"(long-term memory)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010021"(amylopectin biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031550"(positive regulation of brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044381"(glucose import in response to insulin stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046323"(glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0098694"(regulation of synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0098793"(presynapse)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002441("Glucose transporter, type 4 (GLUT4)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-189200|ensembl:ENSRNOG00000017226(gene)|ensembl:ENSRNOT00000023256(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)	rgd:1359188|refseq:NP_001013982.1|ensembl:ENSRNOG00000003782(gene)|ensembl:ENSRNOT00000005033(transcript)|go:"GO:0003986"(acetyl-CoA hydrolase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0006637"(acyl-CoA metabolic process)|go:"GO:0047617"(acyl-CoA hydrolase activity)|interpro:IPR029069|interpro:IPR033120|reactome:R-RNO-77289	-	-	-	caution:"The participant EBI-349571(P68370) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919386(Q7TP47) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920972(Q5XIP9) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-916419(P11980) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919578(Q8R491) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920554(Q5U3Z7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920647(Q5U2X8) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920585(Q7TP24) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-779677(P05426) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-915744(P02454) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|agonist:Insulin was shown to increase or decrease GLUT4 protein interactions in specific cases.|comment:"Insulin decreased GLUT4 interactions with the following proteins: Q9ER30 (Sarcosin), P09527 (Rab-7), O88960 (N-ethylmaleimide sensitive), P09456 (PKA I regulatory subunit), P27881 (Hexokinase type II), P07872 (Acyl-coenzyme A oxidase), Q6DGF1 (Isocitrate dehydrogenase), Q9EQX9 (Ubiquitin-conjugating), Q63446 (Polyubiquitin), P24268 (Cathepsin D), Q91XW0 (Heat shock protein 86), Q5FVH0 (unknown), P58405 (Striatin 3), Q62667 (Major vault protein), Q66H50 (unknown), Q09167 (splicing factor), Q9JHU5 (Arfaptin 1)."|comment:"Insulin increased GLUT4 interaction with the following proteins:Q9Z1P2 (R-actinin-1), P45592 (Cofilin), Q9QXQ0 (R-actinin-4), P26473 (ADP-ribosylation factor), P26437 (ADP-ribosylation factor),   Q7TNP1 (Basigin 2), Q6P6R2 (Dihydrolipoamide dehydrogenase),   P04797 (GAPDH), Q63081 (Protein disulfide isomerase), P29457 (47 kDa heat shock protein), Q9R1J8 (Leprecan), O88638 (Putative eps protein),   Q64375 (Synaptonemal complex)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:NDPK - Interactions involving proteins containing InterPro domain IPR001564, Nucleoside diphosphate kinase, core.	taxid:10116(rat-l6)|taxid:10116(Rattus norvegicus)	-	2006/02/15	2021/11/30	rogid:PbFY2lfrty8yw40Jq7ShR7xfuV410116	rogid:fzFWIdPqPVfI+z1Kl3OOn81C26k10116	intact-crc:44F3A2176D02515F|rigid:9RVm0UBcqQF4k06RGKO89Bg16Q8	false	myc tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P19357	uniprotkb:Q68FT7	intact:EBI-915426|uniprotkb:P97900|ensembl:ENSRNOP00000023256	intact:EBI-920636|ensembl:ENSRNOP00000019685	psi-mi:glut4_rat(display_long)|uniprotkb:Glucose transporter type 4, insulin-responsive(gene name synonym)|uniprotkb:Slc2a4(gene name)|psi-mi:Slc2a4(display_short)|uniprotkb:Glut4(gene name synonym)	psi-mi:q68ft7_rat(display_long)|uniprotkb:Farsb(gene name)|psi-mi:Farsb(display_short)|uniprotkb:Farslb(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Foster et al. (2006)	pubmed:16396496|mint:MINT-5218203	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-921030	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2711|refseq:NP_036883.1|refseq:XP_006246658.1|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007611"(learning or memory)|go:"GO:0007614"(short-term memory)|go:"GO:0007616"(long-term memory)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010021"(amylopectin biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031550"(positive regulation of brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044381"(glucose import in response to insulin stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046323"(glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0098694"(regulation of synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0098793"(presynapse)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002441("Glucose transporter, type 4 (GLUT4)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-189200|ensembl:ENSRNOG00000017226(gene)|ensembl:ENSRNOT00000023256(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)	rgd:1303210|refseq:NP_001004252.1|ensembl:ENSRNOG00000014119(gene)|ensembl:ENSRNOT00000019685(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0003723"(RNA binding)|go:"GO:0004826"(phenylalanine-tRNA ligase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0006432"(phenylalanyl-tRNA aminoacylation)|go:"GO:0009328"(phenylalanine-tRNA ligase complex)|go:"GO:0051290"(protein heterotetramerization)|interpro:IPR004531(Phenylalanyl-tRNA synthetase, class IIc, beta subunit, archae/euk cytosolic)|interpro:IPR005146(B3/B4 tRNA-binding domain)|interpro:IPR005147(tRNA synthetase, B5)|interpro:IPR009061(Putative DNA binding)|interpro:IPR020825|interpro:IPR040659|interpro:IPR041616|mint:Q68FT7	-	-	-	caution:"The participant EBI-349571(P68370) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919386(Q7TP47) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920972(Q5XIP9) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-916419(P11980) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919578(Q8R491) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920554(Q5U3Z7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920647(Q5U2X8) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920585(Q7TP24) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-779677(P05426) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-915744(P02454) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|agonist:Insulin was shown to increase or decrease GLUT4 protein interactions in specific cases.|comment:"Insulin decreased GLUT4 interactions with the following proteins: Q9ER30 (Sarcosin), P09527 (Rab-7), O88960 (N-ethylmaleimide sensitive), P09456 (PKA I regulatory subunit), P27881 (Hexokinase type II), P07872 (Acyl-coenzyme A oxidase), Q6DGF1 (Isocitrate dehydrogenase), Q9EQX9 (Ubiquitin-conjugating), Q63446 (Polyubiquitin), P24268 (Cathepsin D), Q91XW0 (Heat shock protein 86), Q5FVH0 (unknown), P58405 (Striatin 3), Q62667 (Major vault protein), Q66H50 (unknown), Q09167 (splicing factor), Q9JHU5 (Arfaptin 1)."|comment:"Insulin increased GLUT4 interaction with the following proteins:Q9Z1P2 (R-actinin-1), P45592 (Cofilin), Q9QXQ0 (R-actinin-4), P26473 (ADP-ribosylation factor), P26437 (ADP-ribosylation factor),   Q7TNP1 (Basigin 2), Q6P6R2 (Dihydrolipoamide dehydrogenase),   P04797 (GAPDH), Q63081 (Protein disulfide isomerase), P29457 (47 kDa heat shock protein), Q9R1J8 (Leprecan), O88638 (Putative eps protein),   Q64375 (Synaptonemal complex)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:NDPK - Interactions involving proteins containing InterPro domain IPR001564, Nucleoside diphosphate kinase, core.	taxid:10116(rat-l6)|taxid:10116(Rattus norvegicus)	-	2006/02/15	2021/11/30	rogid:PbFY2lfrty8yw40Jq7ShR7xfuV410116	rogid:B105F4rJ0dzzAWry1hOILS2gXJo10116	intact-crc:44F3A2176D02515F|rigid:9RVm0UBcqQF4k06RGKO89Bg16Q8	false	myc tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P19357	uniprotkb:Q4G067	intact:EBI-915426|uniprotkb:P97900|ensembl:ENSRNOP00000023256	intact:EBI-920625|ensembl:ENSRNOP00000020420	psi-mi:glut4_rat(display_long)|uniprotkb:Glucose transporter type 4, insulin-responsive(gene name synonym)|uniprotkb:Slc2a4(gene name)|psi-mi:Slc2a4(display_short)|uniprotkb:Glut4(gene name synonym)	psi-mi:q4g067_rat(display_long)|uniprotkb:Mrpl44(gene name)|psi-mi:Mrpl44(display_short)|uniprotkb:rCG_23950(orf name)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Foster et al. (2006)	pubmed:16396496|mint:MINT-5218203	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-921030	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2711|refseq:NP_036883.1|refseq:XP_006246658.1|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007611"(learning or memory)|go:"GO:0007614"(short-term memory)|go:"GO:0007616"(long-term memory)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010021"(amylopectin biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031550"(positive regulation of brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044381"(glucose import in response to insulin stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046323"(glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0098694"(regulation of synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0098793"(presynapse)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002441("Glucose transporter, type 4 (GLUT4)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-189200|ensembl:ENSRNOG00000017226(gene)|ensembl:ENSRNOT00000023256(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)	rgd:1309556|refseq:NP_001026820.1|ensembl:ENSRNOG00000015231(gene)|ensembl:ENSRNOT00000020420(transcript)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0004525"(ribonuclease III activity)|go:"GO:0005634"(nucleus)|go:"GO:0005762"(mitochondrial large ribosomal subunit)|go:"GO:0005886"(plasma membrane)|go:"GO:0006396"(RNA processing)|go:"GO:0016604"(nuclear body)|go:"GO:0030422"(production of siRNA involved in RNA interference)|go:"GO:0031053"(primary miRNA processing)|go:"GO:0031054"(pre-miRNA processing)|go:"GO:0070125"(mitochondrial translational elongation)|interpro:IPR014720(Double-stranded RNA-binding-like)|interpro:IPR036389|interpro:IPR044444|reactome:R-RNO-5389840|reactome:R-RNO-5419276	-	-	-	caution:"The participant EBI-349571(P68370) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919386(Q7TP47) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920972(Q5XIP9) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-916419(P11980) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919578(Q8R491) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920554(Q5U3Z7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920647(Q5U2X8) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920585(Q7TP24) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-779677(P05426) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-915744(P02454) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|agonist:Insulin was shown to increase or decrease GLUT4 protein interactions in specific cases.|comment:"Insulin decreased GLUT4 interactions with the following proteins: Q9ER30 (Sarcosin), P09527 (Rab-7), O88960 (N-ethylmaleimide sensitive), P09456 (PKA I regulatory subunit), P27881 (Hexokinase type II), P07872 (Acyl-coenzyme A oxidase), Q6DGF1 (Isocitrate dehydrogenase), Q9EQX9 (Ubiquitin-conjugating), Q63446 (Polyubiquitin), P24268 (Cathepsin D), Q91XW0 (Heat shock protein 86), Q5FVH0 (unknown), P58405 (Striatin 3), Q62667 (Major vault protein), Q66H50 (unknown), Q09167 (splicing factor), Q9JHU5 (Arfaptin 1)."|comment:"Insulin increased GLUT4 interaction with the following proteins:Q9Z1P2 (R-actinin-1), P45592 (Cofilin), Q9QXQ0 (R-actinin-4), P26473 (ADP-ribosylation factor), P26437 (ADP-ribosylation factor),   Q7TNP1 (Basigin 2), Q6P6R2 (Dihydrolipoamide dehydrogenase),   P04797 (GAPDH), Q63081 (Protein disulfide isomerase), P29457 (47 kDa heat shock protein), Q9R1J8 (Leprecan), O88638 (Putative eps protein),   Q64375 (Synaptonemal complex)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:NDPK - Interactions involving proteins containing InterPro domain IPR001564, Nucleoside diphosphate kinase, core.	taxid:10116(rat-l6)|taxid:10116(Rattus norvegicus)	-	2006/02/15	2021/11/30	rogid:PbFY2lfrty8yw40Jq7ShR7xfuV410116	rogid:XyGVPDeEoiAGu4Ga8yPQ8fdgP3s10116	intact-crc:44F3A2176D02515F|rigid:9RVm0UBcqQF4k06RGKO89Bg16Q8	false	myc tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P19357	uniprotkb:Q4V8H5	intact:EBI-915426|uniprotkb:P97900|ensembl:ENSRNOP00000023256	intact:EBI-920617|ensembl:ENSRNOP00000026799	psi-mi:glut4_rat(display_long)|uniprotkb:Glucose transporter type 4, insulin-responsive(gene name synonym)|uniprotkb:Slc2a4(gene name)|psi-mi:Slc2a4(display_short)|uniprotkb:Glut4(gene name synonym)	psi-mi:q4v8h5_rat(display_long)|uniprotkb:Dnpep(gene name)|psi-mi:Dnpep(display_short)|uniprotkb:rCG_23931(orf name)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Foster et al. (2006)	pubmed:16396496|mint:MINT-5218203	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-921030	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2711|refseq:NP_036883.1|refseq:XP_006246658.1|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007611"(learning or memory)|go:"GO:0007614"(short-term memory)|go:"GO:0007616"(long-term memory)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010021"(amylopectin biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031550"(positive regulation of brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044381"(glucose import in response to insulin stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046323"(glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0098694"(regulation of synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0098793"(presynapse)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002441("Glucose transporter, type 4 (GLUT4)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-189200|ensembl:ENSRNOG00000017226(gene)|ensembl:ENSRNOT00000023256(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)	rgd:1583848|refseq:NP_001020050.1|ensembl:ENSRNOG00000019772(gene)|ensembl:ENSRNOT00000026799(transcript)|go:"GO:0004177"(aminopeptidase activity)|go:"GO:0005829"(cytosol)|go:"GO:0008237"(metallopeptidase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0042802"(identical protein binding)|interpro:IPR001948(Peptidase M18, aminopeptidase I)|interpro:IPR023358	-	-	-	caution:"The participant EBI-349571(P68370) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919386(Q7TP47) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920972(Q5XIP9) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-916419(P11980) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919578(Q8R491) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920554(Q5U3Z7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920647(Q5U2X8) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920585(Q7TP24) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-779677(P05426) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-915744(P02454) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|agonist:Insulin was shown to increase or decrease GLUT4 protein interactions in specific cases.|comment:"Insulin decreased GLUT4 interactions with the following proteins: Q9ER30 (Sarcosin), P09527 (Rab-7), O88960 (N-ethylmaleimide sensitive), P09456 (PKA I regulatory subunit), P27881 (Hexokinase type II), P07872 (Acyl-coenzyme A oxidase), Q6DGF1 (Isocitrate dehydrogenase), Q9EQX9 (Ubiquitin-conjugating), Q63446 (Polyubiquitin), P24268 (Cathepsin D), Q91XW0 (Heat shock protein 86), Q5FVH0 (unknown), P58405 (Striatin 3), Q62667 (Major vault protein), Q66H50 (unknown), Q09167 (splicing factor), Q9JHU5 (Arfaptin 1)."|comment:"Insulin increased GLUT4 interaction with the following proteins:Q9Z1P2 (R-actinin-1), P45592 (Cofilin), Q9QXQ0 (R-actinin-4), P26473 (ADP-ribosylation factor), P26437 (ADP-ribosylation factor),   Q7TNP1 (Basigin 2), Q6P6R2 (Dihydrolipoamide dehydrogenase),   P04797 (GAPDH), Q63081 (Protein disulfide isomerase), P29457 (47 kDa heat shock protein), Q9R1J8 (Leprecan), O88638 (Putative eps protein),   Q64375 (Synaptonemal complex)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:NDPK - Interactions involving proteins containing InterPro domain IPR001564, Nucleoside diphosphate kinase, core.	taxid:10116(rat-l6)|taxid:10116(Rattus norvegicus)	-	2006/02/15	2021/11/30	rogid:PbFY2lfrty8yw40Jq7ShR7xfuV410116	rogid:R59aa48V2bjCVoC3l5osrhzVGhM10116	intact-crc:44F3A2176D02515F|rigid:9RVm0UBcqQF4k06RGKO89Bg16Q8	false	myc tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P19357	uniprotkb:Q5XIM0	intact:EBI-915426|uniprotkb:P97900|ensembl:ENSRNOP00000023256	intact:EBI-920607|ensembl:ENSRNOP00000022632	psi-mi:glut4_rat(display_long)|uniprotkb:Glucose transporter type 4, insulin-responsive(gene name synonym)|uniprotkb:Slc2a4(gene name)|psi-mi:Slc2a4(display_short)|uniprotkb:Glut4(gene name synonym)	psi-mi:q5xim0_rat(display_long)|uniprotkb:Bcs1l(gene name)|psi-mi:Bcs1l(display_short)|uniprotkb:Mitochondrial chaperone BCS1(gene name synonym)|uniprotkb:rCG_23806(orf name)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Foster et al. (2006)	pubmed:16396496|mint:MINT-5218203	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-921030	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2711|refseq:NP_036883.1|refseq:XP_006246658.1|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007611"(learning or memory)|go:"GO:0007614"(short-term memory)|go:"GO:0007616"(long-term memory)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010021"(amylopectin biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031550"(positive regulation of brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044381"(glucose import in response to insulin stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046323"(glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0098694"(regulation of synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0098793"(presynapse)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002441("Glucose transporter, type 4 (GLUT4)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-189200|ensembl:ENSRNOG00000017226(gene)|ensembl:ENSRNOT00000023256(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)	rgd:1359658|refseq:NP_001007667.1|ensembl:ENSRNOG00000016754(gene)|ensembl:ENSRNOT00000022632(transcript)|go:"GO:0005524"(ATP binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0032979"(protein insertion into mitochondrial inner membrane from matrix)|go:"GO:0032981"(mitochondrial respiratory chain complex I assembly)|go:"GO:0033617"(mitochondrial cytochrome c oxidase assembly)|go:"GO:0034551"(mitochondrial respiratory chain complex III assembly)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR003959(AAA ATPase, core)|interpro:IPR003960(AAA ATPase, conserved site)|interpro:IPR014851(BCS1 N terminal)|interpro:IPR027417|refseq:XP_017451859.1|refseq:XP_017451860.1	-	-	-	caution:"The participant EBI-349571(P68370) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919386(Q7TP47) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920972(Q5XIP9) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-916419(P11980) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919578(Q8R491) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920554(Q5U3Z7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920647(Q5U2X8) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920585(Q7TP24) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-779677(P05426) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-915744(P02454) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|agonist:Insulin was shown to increase or decrease GLUT4 protein interactions in specific cases.|comment:"Insulin decreased GLUT4 interactions with the following proteins: Q9ER30 (Sarcosin), P09527 (Rab-7), O88960 (N-ethylmaleimide sensitive), P09456 (PKA I regulatory subunit), P27881 (Hexokinase type II), P07872 (Acyl-coenzyme A oxidase), Q6DGF1 (Isocitrate dehydrogenase), Q9EQX9 (Ubiquitin-conjugating), Q63446 (Polyubiquitin), P24268 (Cathepsin D), Q91XW0 (Heat shock protein 86), Q5FVH0 (unknown), P58405 (Striatin 3), Q62667 (Major vault protein), Q66H50 (unknown), Q09167 (splicing factor), Q9JHU5 (Arfaptin 1)."|comment:"Insulin increased GLUT4 interaction with the following proteins:Q9Z1P2 (R-actinin-1), P45592 (Cofilin), Q9QXQ0 (R-actinin-4), P26473 (ADP-ribosylation factor), P26437 (ADP-ribosylation factor),   Q7TNP1 (Basigin 2), Q6P6R2 (Dihydrolipoamide dehydrogenase),   P04797 (GAPDH), Q63081 (Protein disulfide isomerase), P29457 (47 kDa heat shock protein), Q9R1J8 (Leprecan), O88638 (Putative eps protein),   Q64375 (Synaptonemal complex)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:NDPK - Interactions involving proteins containing InterPro domain IPR001564, Nucleoside diphosphate kinase, core.	taxid:10116(rat-l6)|taxid:10116(Rattus norvegicus)	-	2006/02/15	2021/11/30	rogid:PbFY2lfrty8yw40Jq7ShR7xfuV410116	rogid:h3gKpvBPwxt/twrg1C8WAu7iQ3M10116	intact-crc:44F3A2176D02515F|rigid:9RVm0UBcqQF4k06RGKO89Bg16Q8	false	myc tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P19357	uniprotkb:Q5PQL2	intact:EBI-915426|uniprotkb:P97900|ensembl:ENSRNOP00000023256	intact:EBI-920599|ensembl:ENSRNOP00000021548	psi-mi:glut4_rat(display_long)|uniprotkb:Glucose transporter type 4, insulin-responsive(gene name synonym)|uniprotkb:Slc2a4(gene name)|psi-mi:Slc2a4(display_short)|uniprotkb:Glut4(gene name synonym)	psi-mi:cnot9_rat(display_long)|uniprotkb:Cell differentiation protein RQCD1 homolog(gene name synonym)|uniprotkb:Cnot9(gene name)|psi-mi:Cnot9(display_short)|uniprotkb:Rcd1(gene name synonym)|uniprotkb:Rqcd1(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Foster et al. (2006)	pubmed:16396496|mint:MINT-5218203	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-921030	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2711|refseq:NP_036883.1|refseq:XP_006246658.1|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007611"(learning or memory)|go:"GO:0007614"(short-term memory)|go:"GO:0007616"(long-term memory)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010021"(amylopectin biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031550"(positive regulation of brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044381"(glucose import in response to insulin stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046323"(glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0098694"(regulation of synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0098793"(presynapse)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002441("Glucose transporter, type 4 (GLUT4)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-189200|ensembl:ENSRNOG00000017226(gene)|ensembl:ENSRNOT00000023256(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)	rgd:1311495|refseq:NP_001009357.1|ensembl:ENSRNOG00000016034(gene)|ensembl:ENSRNOT00000021548(transcript)|go:"GO:0000932"(P-body)|go:"GO:0005154"(epidermal growth factor receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0006402"(mRNA catabolic process)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019900"(kinase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030014"(CCR4-NOT complex)|go:"GO:0030015"(CCR4-NOT core complex)|go:"GO:0030374"(nuclear receptor coactivator activity)|go:"GO:0031047"(gene silencing by RNA)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0033147"(negative regulation of intracellular estrogen receptor signaling pathway)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0045742"(positive regulation of epidermal growth factor receptor signaling pathway)|interpro:IPR007216(Cell differentiation, Rcd1-like)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|reactome:R-RNO-429947|reactome:R-RNO-6804115	-	-	-	caution:"The participant EBI-349571(P68370) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919386(Q7TP47) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920972(Q5XIP9) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-916419(P11980) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919578(Q8R491) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920554(Q5U3Z7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920647(Q5U2X8) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920585(Q7TP24) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-779677(P05426) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-915744(P02454) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|agonist:Insulin was shown to increase or decrease GLUT4 protein interactions in specific cases.|comment:"Insulin decreased GLUT4 interactions with the following proteins: Q9ER30 (Sarcosin), P09527 (Rab-7), O88960 (N-ethylmaleimide sensitive), P09456 (PKA I regulatory subunit), P27881 (Hexokinase type II), P07872 (Acyl-coenzyme A oxidase), Q6DGF1 (Isocitrate dehydrogenase), Q9EQX9 (Ubiquitin-conjugating), Q63446 (Polyubiquitin), P24268 (Cathepsin D), Q91XW0 (Heat shock protein 86), Q5FVH0 (unknown), P58405 (Striatin 3), Q62667 (Major vault protein), Q66H50 (unknown), Q09167 (splicing factor), Q9JHU5 (Arfaptin 1)."|comment:"Insulin increased GLUT4 interaction with the following proteins:Q9Z1P2 (R-actinin-1), P45592 (Cofilin), Q9QXQ0 (R-actinin-4), P26473 (ADP-ribosylation factor), P26437 (ADP-ribosylation factor),   Q7TNP1 (Basigin 2), Q6P6R2 (Dihydrolipoamide dehydrogenase),   P04797 (GAPDH), Q63081 (Protein disulfide isomerase), P29457 (47 kDa heat shock protein), Q9R1J8 (Leprecan), O88638 (Putative eps protein),   Q64375 (Synaptonemal complex)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:NDPK - Interactions involving proteins containing InterPro domain IPR001564, Nucleoside diphosphate kinase, core.	taxid:10116(rat-l6)|taxid:10116(Rattus norvegicus)	-	2006/02/15	2021/11/30	rogid:PbFY2lfrty8yw40Jq7ShR7xfuV410116	rogid:dFdbI7Ohvu0vtwY45V/pyKNTT/810116	intact-crc:44F3A2176D02515F|rigid:9RVm0UBcqQF4k06RGKO89Bg16Q8	false	myc tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P19357	uniprotkb:Q7TP47	intact:EBI-915426|uniprotkb:P97900|ensembl:ENSRNOP00000023256	intact:EBI-919386|ensembl:ENSRNOP00000048433	psi-mi:glut4_rat(display_long)|uniprotkb:Glucose transporter type 4, insulin-responsive(gene name synonym)|uniprotkb:Slc2a4(gene name)|psi-mi:Slc2a4(display_short)|uniprotkb:Glut4(gene name synonym)	psi-mi:hnrpq_rat(display_long)|uniprotkb:Syncrip(gene name)|psi-mi:Syncrip(display_short)|uniprotkb:Hnrpq(gene name synonym)|uniprotkb:Ab2-339(orf name)|uniprotkb:Synaptotagmin-binding, cytoplasmic RNA-interacting protein(gene name synonym)|uniprotkb:Liver regeneration-related protein LRRG077(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Foster et al. (2006)	pubmed:16396496|mint:MINT-5218203	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-921030	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2711|refseq:NP_036883.1|refseq:XP_006246658.1|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007611"(learning or memory)|go:"GO:0007614"(short-term memory)|go:"GO:0007616"(long-term memory)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010021"(amylopectin biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031550"(positive regulation of brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044381"(glucose import in response to insulin stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046323"(glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0098694"(regulation of synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0098793"(presynapse)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002441("Glucose transporter, type 4 (GLUT4)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-189200|ensembl:ENSRNOG00000017226(gene)|ensembl:ENSRNOT00000023256(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)	rgd:1305683|refseq:NP_001041381.1|ensembl:ENSRNOG00000000204(gene)|ensembl:ENSRNOT00000041655(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0006397"(mRNA processing)|go:"GO:0007623"(circadian rhythm)|go:"GO:0008143"("poly(A) binding")|go:"GO:0008380"(RNA splicing)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0043025"(neuronal cell body)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0048027"(mRNA 5'-UTR binding)|go:"GO:0070934"(CRD-mediated mRNA stabilization)|go:"GO:0070937"(CRD-mediated mRNA stability complex)|go:"GO:0071013"(catalytic step 2 spliceosome)|go:"GO:0071204"(histone pre-mRNA 3'end processing complex)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0090367"(negative regulation of mRNA modification)|go:"GO:0097452"(GAIT complex)|go:"GO:1990635"(proximal dendrite)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR006535(HnRNP R and Q splicing factor)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR034544|interpro:IPR034548|interpro:IPR035979|mint:Q7TP47	-	-	-	caution:"The participant EBI-349571(P68370) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919386(Q7TP47) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920972(Q5XIP9) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-916419(P11980) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919578(Q8R491) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920554(Q5U3Z7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920647(Q5U2X8) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920585(Q7TP24) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-779677(P05426) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-915744(P02454) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|agonist:Insulin was shown to increase or decrease GLUT4 protein interactions in specific cases.|comment:"Insulin decreased GLUT4 interactions with the following proteins: Q9ER30 (Sarcosin), P09527 (Rab-7), O88960 (N-ethylmaleimide sensitive), P09456 (PKA I regulatory subunit), P27881 (Hexokinase type II), P07872 (Acyl-coenzyme A oxidase), Q6DGF1 (Isocitrate dehydrogenase), Q9EQX9 (Ubiquitin-conjugating), Q63446 (Polyubiquitin), P24268 (Cathepsin D), Q91XW0 (Heat shock protein 86), Q5FVH0 (unknown), P58405 (Striatin 3), Q62667 (Major vault protein), Q66H50 (unknown), Q09167 (splicing factor), Q9JHU5 (Arfaptin 1)."|comment:"Insulin increased GLUT4 interaction with the following proteins:Q9Z1P2 (R-actinin-1), P45592 (Cofilin), Q9QXQ0 (R-actinin-4), P26473 (ADP-ribosylation factor), P26437 (ADP-ribosylation factor),   Q7TNP1 (Basigin 2), Q6P6R2 (Dihydrolipoamide dehydrogenase),   P04797 (GAPDH), Q63081 (Protein disulfide isomerase), P29457 (47 kDa heat shock protein), Q9R1J8 (Leprecan), O88638 (Putative eps protein),   Q64375 (Synaptonemal complex)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:NDPK - Interactions involving proteins containing InterPro domain IPR001564, Nucleoside diphosphate kinase, core.	taxid:10116(rat-l6)|taxid:10116(Rattus norvegicus)	-	2006/02/15	2021/11/30	rogid:PbFY2lfrty8yw40Jq7ShR7xfuV410116	rogid:AETEMoY8iTxnVf1mtSgs1TKDwwk10116	intact-crc:44F3A2176D02515F|rigid:9RVm0UBcqQF4k06RGKO89Bg16Q8	false	myc tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P19357	uniprotkb:Q68FY0	intact:EBI-915426|uniprotkb:P97900|ensembl:ENSRNOP00000023256	intact:EBI-920593|ensembl:ENSRNOP00000044696	psi-mi:glut4_rat(display_long)|uniprotkb:Glucose transporter type 4, insulin-responsive(gene name synonym)|uniprotkb:Slc2a4(gene name)|psi-mi:Slc2a4(display_short)|uniprotkb:Glut4(gene name synonym)	psi-mi:qcr1_rat(display_long)|uniprotkb:Uqcrc1(gene name)|psi-mi:Uqcrc1(display_short)|uniprotkb:Ubiquinol-cytochrome-c reductase complex core protein 1(gene name synonym)|uniprotkb:Complex III subunit 1(gene name synonym)|uniprotkb:Core protein I(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Foster et al. (2006)	pubmed:16396496|mint:MINT-5218203	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-921030	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2711|refseq:NP_036883.1|refseq:XP_006246658.1|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007611"(learning or memory)|go:"GO:0007614"(short-term memory)|go:"GO:0007616"(long-term memory)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010021"(amylopectin biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031550"(positive regulation of brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044381"(glucose import in response to insulin stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046323"(glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0098694"(regulation of synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0098793"(presynapse)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002441("Glucose transporter, type 4 (GLUT4)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-189200|ensembl:ENSRNOG00000017226(gene)|ensembl:ENSRNOT00000023256(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)	rgd:1303314|refseq:NP_001004250.1|ensembl:ENSRNOG00000032134(gene)|ensembl:ENSRNOT00000042114(transcript)|go:"GO:0005739"(mitochondrion)|go:"GO:0005750"(mitochondrial respiratory chain complex III)|go:"GO:0006122"(mitochondrial electron transport, ubiquinol to cytochrome c)|go:"GO:0014823"(response to activity)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0043279"(response to alkaloid)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046872"(metal ion binding)|interpro:IPR007863(Peptidase M16, C-terminal)|interpro:IPR011249(Metalloenzyme, LuxS/M16 peptidase-like, metal-binding)|interpro:IPR011765(Peptidase M16, N-terminal)|reactome:R-RNO-611105	-	-	-	caution:"The participant EBI-349571(P68370) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919386(Q7TP47) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920972(Q5XIP9) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-916419(P11980) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919578(Q8R491) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920554(Q5U3Z7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920647(Q5U2X8) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920585(Q7TP24) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-779677(P05426) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-915744(P02454) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|agonist:Insulin was shown to increase or decrease GLUT4 protein interactions in specific cases.|comment:"Insulin decreased GLUT4 interactions with the following proteins: Q9ER30 (Sarcosin), P09527 (Rab-7), O88960 (N-ethylmaleimide sensitive), P09456 (PKA I regulatory subunit), P27881 (Hexokinase type II), P07872 (Acyl-coenzyme A oxidase), Q6DGF1 (Isocitrate dehydrogenase), Q9EQX9 (Ubiquitin-conjugating), Q63446 (Polyubiquitin), P24268 (Cathepsin D), Q91XW0 (Heat shock protein 86), Q5FVH0 (unknown), P58405 (Striatin 3), Q62667 (Major vault protein), Q66H50 (unknown), Q09167 (splicing factor), Q9JHU5 (Arfaptin 1)."|comment:"Insulin increased GLUT4 interaction with the following proteins:Q9Z1P2 (R-actinin-1), P45592 (Cofilin), Q9QXQ0 (R-actinin-4), P26473 (ADP-ribosylation factor), P26437 (ADP-ribosylation factor),   Q7TNP1 (Basigin 2), Q6P6R2 (Dihydrolipoamide dehydrogenase),   P04797 (GAPDH), Q63081 (Protein disulfide isomerase), P29457 (47 kDa heat shock protein), Q9R1J8 (Leprecan), O88638 (Putative eps protein),   Q64375 (Synaptonemal complex)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:NDPK - Interactions involving proteins containing InterPro domain IPR001564, Nucleoside diphosphate kinase, core.	taxid:10116(rat-l6)|taxid:10116(Rattus norvegicus)	-	2006/02/15	2021/11/30	rogid:PbFY2lfrty8yw40Jq7ShR7xfuV410116	rogid:Lo296kkmjgadqh6O18HeqYBuYrQ10116	intact-crc:44F3A2176D02515F|rigid:9RVm0UBcqQF4k06RGKO89Bg16Q8	false	myc tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P19357	uniprotkb:Q7TP24	intact:EBI-915426|uniprotkb:P97900|ensembl:ENSRNOP00000023256	intact:EBI-920585	psi-mi:glut4_rat(display_long)|uniprotkb:Glucose transporter type 4, insulin-responsive(gene name synonym)|uniprotkb:Slc2a4(gene name)|psi-mi:Slc2a4(display_short)|uniprotkb:Glut4(gene name synonym)	psi-mi:q7tp24_rat(display_long)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Foster et al. (2006)	pubmed:16396496|mint:MINT-5218203	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-921030	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2711|refseq:NP_036883.1|refseq:XP_006246658.1|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007611"(learning or memory)|go:"GO:0007614"(short-term memory)|go:"GO:0007616"(long-term memory)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010021"(amylopectin biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031550"(positive regulation of brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044381"(glucose import in response to insulin stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046323"(glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0098694"(regulation of synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0098793"(presynapse)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002441("Glucose transporter, type 4 (GLUT4)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-189200|ensembl:ENSRNOG00000017226(gene)|ensembl:ENSRNOT00000023256(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)	interpro:IPR001156(Peptidase S60, transferrin lactoferrin)|interpro:IPR019009|interpro:IPR018195|go:"GO:0005525"(GTP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0016021"(integral component of membrane)|interpro:IPR027417	-	-	-	caution:"The participant EBI-349571(P68370) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919386(Q7TP47) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920972(Q5XIP9) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-916419(P11980) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919578(Q8R491) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920554(Q5U3Z7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920647(Q5U2X8) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920585(Q7TP24) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-779677(P05426) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-915744(P02454) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|agonist:Insulin was shown to increase or decrease GLUT4 protein interactions in specific cases.|comment:"Insulin decreased GLUT4 interactions with the following proteins: Q9ER30 (Sarcosin), P09527 (Rab-7), O88960 (N-ethylmaleimide sensitive), P09456 (PKA I regulatory subunit), P27881 (Hexokinase type II), P07872 (Acyl-coenzyme A oxidase), Q6DGF1 (Isocitrate dehydrogenase), Q9EQX9 (Ubiquitin-conjugating), Q63446 (Polyubiquitin), P24268 (Cathepsin D), Q91XW0 (Heat shock protein 86), Q5FVH0 (unknown), P58405 (Striatin 3), Q62667 (Major vault protein), Q66H50 (unknown), Q09167 (splicing factor), Q9JHU5 (Arfaptin 1)."|comment:"Insulin increased GLUT4 interaction with the following proteins:Q9Z1P2 (R-actinin-1), P45592 (Cofilin), Q9QXQ0 (R-actinin-4), P26473 (ADP-ribosylation factor), P26437 (ADP-ribosylation factor),   Q7TNP1 (Basigin 2), Q6P6R2 (Dihydrolipoamide dehydrogenase),   P04797 (GAPDH), Q63081 (Protein disulfide isomerase), P29457 (47 kDa heat shock protein), Q9R1J8 (Leprecan), O88638 (Putative eps protein),   Q64375 (Synaptonemal complex)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:NDPK - Interactions involving proteins containing InterPro domain IPR001564, Nucleoside diphosphate kinase, core.	taxid:10116(rat-l6)|taxid:10116(Rattus norvegicus)	-	2006/02/15	2021/11/30	rogid:PbFY2lfrty8yw40Jq7ShR7xfuV410116	rogid:DogMExEyNXWk6vU6tAFxVKZEWx410116	intact-crc:44F3A2176D02515F|rigid:9RVm0UBcqQF4k06RGKO89Bg16Q8	false	myc tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P19357	uniprotkb:Q7TMC7	intact:EBI-915426|uniprotkb:P97900|ensembl:ENSRNOP00000023256	intact:EBI-920577|uniprotkb:F1LMP2	psi-mi:glut4_rat(display_long)|uniprotkb:Glucose transporter type 4, insulin-responsive(gene name synonym)|uniprotkb:Slc2a4(gene name)|psi-mi:Slc2a4(display_short)|uniprotkb:Glut4(gene name synonym)	psi-mi:q7tmc7_rat(display_long)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Foster et al. (2006)	pubmed:16396496|mint:MINT-5218203	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-921030	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2711|refseq:NP_036883.1|refseq:XP_006246658.1|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007611"(learning or memory)|go:"GO:0007614"(short-term memory)|go:"GO:0007616"(long-term memory)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010021"(amylopectin biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031550"(positive regulation of brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044381"(glucose import in response to insulin stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046323"(glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0098694"(regulation of synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0098793"(presynapse)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002441("Glucose transporter, type 4 (GLUT4)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-189200|ensembl:ENSRNOG00000017226(gene)|ensembl:ENSRNOT00000023256(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)	interpro:IPR001156(Peptidase S60, transferrin lactoferrin)|interpro:IPR019009|interpro:IPR018195|go:"GO:0005525"(GTP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0016021"(integral component of membrane)|interpro:IPR027417	-	-	-	caution:"The participant EBI-349571(P68370) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919386(Q7TP47) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920972(Q5XIP9) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-916419(P11980) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919578(Q8R491) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920554(Q5U3Z7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920647(Q5U2X8) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920585(Q7TP24) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-779677(P05426) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-915744(P02454) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|agonist:Insulin was shown to increase or decrease GLUT4 protein interactions in specific cases.|comment:"Insulin decreased GLUT4 interactions with the following proteins: Q9ER30 (Sarcosin), P09527 (Rab-7), O88960 (N-ethylmaleimide sensitive), P09456 (PKA I regulatory subunit), P27881 (Hexokinase type II), P07872 (Acyl-coenzyme A oxidase), Q6DGF1 (Isocitrate dehydrogenase), Q9EQX9 (Ubiquitin-conjugating), Q63446 (Polyubiquitin), P24268 (Cathepsin D), Q91XW0 (Heat shock protein 86), Q5FVH0 (unknown), P58405 (Striatin 3), Q62667 (Major vault protein), Q66H50 (unknown), Q09167 (splicing factor), Q9JHU5 (Arfaptin 1)."|comment:"Insulin increased GLUT4 interaction with the following proteins:Q9Z1P2 (R-actinin-1), P45592 (Cofilin), Q9QXQ0 (R-actinin-4), P26473 (ADP-ribosylation factor), P26437 (ADP-ribosylation factor),   Q7TNP1 (Basigin 2), Q6P6R2 (Dihydrolipoamide dehydrogenase),   P04797 (GAPDH), Q63081 (Protein disulfide isomerase), P29457 (47 kDa heat shock protein), Q9R1J8 (Leprecan), O88638 (Putative eps protein),   Q64375 (Synaptonemal complex)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:NDPK - Interactions involving proteins containing InterPro domain IPR001564, Nucleoside diphosphate kinase, core.	taxid:10116(rat-l6)|taxid:10116(Rattus norvegicus)	-	2006/02/15	2021/11/30	rogid:PbFY2lfrty8yw40Jq7ShR7xfuV410116	rogid:7DdrmKH7pW52vRzJwdJRGHe2ORA10116	intact-crc:44F3A2176D02515F|rigid:9RVm0UBcqQF4k06RGKO89Bg16Q8	false	myc tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P19357	uniprotkb:P05426	intact:EBI-915426|uniprotkb:P97900|ensembl:ENSRNOP00000023256	intact:EBI-779677	psi-mi:glut4_rat(display_long)|uniprotkb:Glucose transporter type 4, insulin-responsive(gene name synonym)|uniprotkb:Slc2a4(gene name)|psi-mi:Slc2a4(display_short)|uniprotkb:Glut4(gene name synonym)	psi-mi:rl7_rat(display_long)|uniprotkb:Rpl7(gene name)|psi-mi:Rpl7(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Foster et al. (2006)	pubmed:16396496|mint:MINT-5218203	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-921030	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2711|refseq:NP_036883.1|refseq:XP_006246658.1|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007611"(learning or memory)|go:"GO:0007614"(short-term memory)|go:"GO:0007616"(long-term memory)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010021"(amylopectin biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031550"(positive regulation of brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044381"(glucose import in response to insulin stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046323"(glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0098694"(regulation of synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0098793"(presynapse)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002441("Glucose transporter, type 4 (GLUT4)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-189200|ensembl:ENSRNOG00000017226(gene)|ensembl:ENSRNOT00000023256(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)	rgd:735169|interpro:IPR018038|interpro:IPR016082(Ribosomal protein L30, C-terminal)|interpro:IPR012988(Ribosomal protein L30, N-terminal)|interpro:IPR005998(Ribosomal protein L7, eukaryotic)|interpro:IPR039699|interpro:IPR035808|interpro:IPR036919|go:"GO:0000463"("maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)")|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0003735"(structural constituent of ribosome)|go:"GO:0005840"(ribosome)|go:"GO:0005844"(polysome)|go:"GO:0006364"(rRNA processing)|go:"GO:0008097"(5S rRNA binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0022625"(cytosolic large ribosomal subunit)|go:"GO:0022626"(cytosolic ribosome)|go:"GO:0031672"(A band)|go:"GO:0042273"(ribosomal large subunit biogenesis)|go:"GO:0042802"(identical protein binding)|go:"GO:0045202"(synapse)|go:"GO:0097421"(liver regeneration)|go:"GO:1990904"(ribonucleoprotein complex)|reactome:R-RNO-156827|reactome:R-RNO-1799339|reactome:R-RNO-6791226|reactome:R-RNO-72689|reactome:R-RNO-72706|reactome:R-RNO-975956|reactome:R-RNO-975957|mint:P05426	-	-	-	caution:"The participant EBI-349571(P68370) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919386(Q7TP47) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920972(Q5XIP9) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-916419(P11980) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919578(Q8R491) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920554(Q5U3Z7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920647(Q5U2X8) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920585(Q7TP24) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-779677(P05426) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-915744(P02454) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|agonist:Insulin was shown to increase or decrease GLUT4 protein interactions in specific cases.|comment:"Insulin decreased GLUT4 interactions with the following proteins: Q9ER30 (Sarcosin), P09527 (Rab-7), O88960 (N-ethylmaleimide sensitive), P09456 (PKA I regulatory subunit), P27881 (Hexokinase type II), P07872 (Acyl-coenzyme A oxidase), Q6DGF1 (Isocitrate dehydrogenase), Q9EQX9 (Ubiquitin-conjugating), Q63446 (Polyubiquitin), P24268 (Cathepsin D), Q91XW0 (Heat shock protein 86), Q5FVH0 (unknown), P58405 (Striatin 3), Q62667 (Major vault protein), Q66H50 (unknown), Q09167 (splicing factor), Q9JHU5 (Arfaptin 1)."|comment:"Insulin increased GLUT4 interaction with the following proteins:Q9Z1P2 (R-actinin-1), P45592 (Cofilin), Q9QXQ0 (R-actinin-4), P26473 (ADP-ribosylation factor), P26437 (ADP-ribosylation factor),   Q7TNP1 (Basigin 2), Q6P6R2 (Dihydrolipoamide dehydrogenase),   P04797 (GAPDH), Q63081 (Protein disulfide isomerase), P29457 (47 kDa heat shock protein), Q9R1J8 (Leprecan), O88638 (Putative eps protein),   Q64375 (Synaptonemal complex)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:NDPK - Interactions involving proteins containing InterPro domain IPR001564, Nucleoside diphosphate kinase, core.	taxid:10116(rat-l6)|taxid:10116(Rattus norvegicus)	-	2006/02/15	2021/11/30	rogid:PbFY2lfrty8yw40Jq7ShR7xfuV410116	rogid:pIpF4885CEJGzSQVuRWK0nx1pgY10116	intact-crc:44F3A2176D02515F|rigid:9RVm0UBcqQF4k06RGKO89Bg16Q8	false	myc tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P19357	uniprotkb:Q641X3	intact:EBI-915426|uniprotkb:P97900|ensembl:ENSRNOP00000023256	intact:EBI-920572|ensembl:ENSRNOP00000013747	psi-mi:glut4_rat(display_long)|uniprotkb:Glucose transporter type 4, insulin-responsive(gene name synonym)|uniprotkb:Slc2a4(gene name)|psi-mi:Slc2a4(display_short)|uniprotkb:Glut4(gene name synonym)	psi-mi:hexa_rat(display_long)|uniprotkb:Hexa(gene name)|psi-mi:Hexa(display_short)|uniprotkb:N-acetyl-beta-glucosaminidase subunit alpha(gene name synonym)|uniprotkb:Beta-N-acetylhexosaminidase subunit alpha(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Foster et al. (2006)	pubmed:16396496|mint:MINT-5218203	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-921030	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2711|refseq:NP_036883.1|refseq:XP_006246658.1|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007611"(learning or memory)|go:"GO:0007614"(short-term memory)|go:"GO:0007616"(long-term memory)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010021"(amylopectin biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031550"(positive regulation of brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044381"(glucose import in response to insulin stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046323"(glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0098694"(regulation of synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0098793"(presynapse)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002441("Glucose transporter, type 4 (GLUT4)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-189200|ensembl:ENSRNOG00000017226(gene)|ensembl:ENSRNOT00000023256(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)	rgd:2792|refseq:NP_001004443.1|ensembl:ENSRNOG00000010252(gene)|ensembl:ENSRNOT00000013747(transcript)|go:"GO:0001501"(skeletal system development)|go:"GO:0004563"(beta-N-acetylhexosaminidase activity)|go:"GO:0005764"(lysosome)|go:"GO:0005975"(carbohydrate metabolic process)|go:"GO:0006024"(glycosaminoglycan biosynthetic process)|go:"GO:0006689"(ganglioside catabolic process)|go:"GO:0007040"(lysosome organization)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0007626"(locomotory behavior)|go:"GO:0007628"(adult walking behavior)|go:"GO:0008375"(acetylglucosaminyltransferase activity)|go:"GO:0016020"(membrane)|go:"GO:0019915"(lipid storage)|go:"GO:0019953"(sexual reproduction)|go:"GO:0030203"(glycosaminoglycan metabolic process)|go:"GO:0042552"(myelination)|go:"GO:0042582"(azurophil granule)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048667"(cell morphogenesis involved in neuron differentiation)|go:"GO:0050884"(neuromuscular process controlling posture)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0060395"(SMAD protein signal transduction)|go:"GO:0102148"(N-acetyl-beta-D-galactosaminidase activity)|interpro:IPR015883(Glycoside hydrolase, family 20, catalytic core)|interpro:IPR017853(Glycoside hydrolase, catalytic core)|interpro:IPR025705|interpro:IPR029018|interpro:IPR029019|reactome:R-RNO-1660662|reactome:R-RNO-2022857|reactome:R-RNO-2024101|reactome:R-RNO-2160916	-	-	-	caution:"The participant EBI-349571(P68370) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919386(Q7TP47) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920972(Q5XIP9) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-916419(P11980) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919578(Q8R491) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920554(Q5U3Z7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920647(Q5U2X8) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920585(Q7TP24) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-779677(P05426) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-915744(P02454) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|agonist:Insulin was shown to increase or decrease GLUT4 protein interactions in specific cases.|comment:"Insulin decreased GLUT4 interactions with the following proteins: Q9ER30 (Sarcosin), P09527 (Rab-7), O88960 (N-ethylmaleimide sensitive), P09456 (PKA I regulatory subunit), P27881 (Hexokinase type II), P07872 (Acyl-coenzyme A oxidase), Q6DGF1 (Isocitrate dehydrogenase), Q9EQX9 (Ubiquitin-conjugating), Q63446 (Polyubiquitin), P24268 (Cathepsin D), Q91XW0 (Heat shock protein 86), Q5FVH0 (unknown), P58405 (Striatin 3), Q62667 (Major vault protein), Q66H50 (unknown), Q09167 (splicing factor), Q9JHU5 (Arfaptin 1)."|comment:"Insulin increased GLUT4 interaction with the following proteins:Q9Z1P2 (R-actinin-1), P45592 (Cofilin), Q9QXQ0 (R-actinin-4), P26473 (ADP-ribosylation factor), P26437 (ADP-ribosylation factor),   Q7TNP1 (Basigin 2), Q6P6R2 (Dihydrolipoamide dehydrogenase),   P04797 (GAPDH), Q63081 (Protein disulfide isomerase), P29457 (47 kDa heat shock protein), Q9R1J8 (Leprecan), O88638 (Putative eps protein),   Q64375 (Synaptonemal complex)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:NDPK - Interactions involving proteins containing InterPro domain IPR001564, Nucleoside diphosphate kinase, core.	taxid:10116(rat-l6)|taxid:10116(Rattus norvegicus)	-	2006/02/15	2021/11/30	rogid:PbFY2lfrty8yw40Jq7ShR7xfuV410116	rogid:I/JoUlNHtY21R/nHW+BrHNuBQr410116	intact-crc:44F3A2176D02515F|rigid:9RVm0UBcqQF4k06RGKO89Bg16Q8	false	myc tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P19357	uniprotkb:Q68FR9	intact:EBI-915426|uniprotkb:P97900|ensembl:ENSRNOP00000023256	intact:EBI-920563	psi-mi:glut4_rat(display_long)|uniprotkb:Glucose transporter type 4, insulin-responsive(gene name synonym)|uniprotkb:Slc2a4(gene name)|psi-mi:Slc2a4(display_short)|uniprotkb:Glut4(gene name synonym)	psi-mi:ef1d_rat(display_long)|uniprotkb:Eef1d(gene name)|psi-mi:Eef1d(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Foster et al. (2006)	pubmed:16396496|mint:MINT-5218203	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-921030	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2711|refseq:NP_036883.1|refseq:XP_006246658.1|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007611"(learning or memory)|go:"GO:0007614"(short-term memory)|go:"GO:0007616"(long-term memory)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010021"(amylopectin biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031550"(positive regulation of brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044381"(glucose import in response to insulin stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046323"(glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0098694"(regulation of synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0098793"(presynapse)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002441("Glucose transporter, type 4 (GLUT4)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-189200|ensembl:ENSRNOG00000017226(gene)|ensembl:ENSRNOT00000023256(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)	rgd:621174|refseq:NP_001013122.1|interpro:IPR018940|interpro:IPR014717(Translation elongation  factor EF1B/ribosomal protein S6)|interpro:IPR001326(Translation elongation factor EF1B, beta/delta chains, conserved site)|interpro:IPR014038(Translation elongation factor EF1B, beta and delta chains, guanine nucleotide exchange)|refseq:XP_008763779.1|refseq:XP_008763780.1|refseq:XP_008763781.1|go:"GO:0001650"(fibrillar center)|go:"GO:0003677"(DNA binding)|go:"GO:0003746"(translation elongation factor activity)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005853"(eukaryotic translation elongation factor 1 complex)|go:"GO:0006414"(translational elongation)|go:"GO:0045202"(synapse)|go:"GO:0071479"(cellular response to ionizing radiation)|go:"GO:0098978"(glutamatergic synapse)|interpro:IPR036219|reactome:R-RNO-156842	-	-	-	caution:"The participant EBI-349571(P68370) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919386(Q7TP47) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920972(Q5XIP9) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-916419(P11980) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919578(Q8R491) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920554(Q5U3Z7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920647(Q5U2X8) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920585(Q7TP24) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-779677(P05426) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-915744(P02454) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|agonist:Insulin was shown to increase or decrease GLUT4 protein interactions in specific cases.|comment:"Insulin decreased GLUT4 interactions with the following proteins: Q9ER30 (Sarcosin), P09527 (Rab-7), O88960 (N-ethylmaleimide sensitive), P09456 (PKA I regulatory subunit), P27881 (Hexokinase type II), P07872 (Acyl-coenzyme A oxidase), Q6DGF1 (Isocitrate dehydrogenase), Q9EQX9 (Ubiquitin-conjugating), Q63446 (Polyubiquitin), P24268 (Cathepsin D), Q91XW0 (Heat shock protein 86), Q5FVH0 (unknown), P58405 (Striatin 3), Q62667 (Major vault protein), Q66H50 (unknown), Q09167 (splicing factor), Q9JHU5 (Arfaptin 1)."|comment:"Insulin increased GLUT4 interaction with the following proteins:Q9Z1P2 (R-actinin-1), P45592 (Cofilin), Q9QXQ0 (R-actinin-4), P26473 (ADP-ribosylation factor), P26437 (ADP-ribosylation factor),   Q7TNP1 (Basigin 2), Q6P6R2 (Dihydrolipoamide dehydrogenase),   P04797 (GAPDH), Q63081 (Protein disulfide isomerase), P29457 (47 kDa heat shock protein), Q9R1J8 (Leprecan), O88638 (Putative eps protein),   Q64375 (Synaptonemal complex)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:NDPK - Interactions involving proteins containing InterPro domain IPR001564, Nucleoside diphosphate kinase, core.	taxid:10116(rat-l6)|taxid:10116(Rattus norvegicus)	-	2006/02/15	2021/11/30	rogid:PbFY2lfrty8yw40Jq7ShR7xfuV410116	rogid:W4owdSoNIk1zWKITlT98pP9CY5Y10116	intact-crc:44F3A2176D02515F|rigid:9RVm0UBcqQF4k06RGKO89Bg16Q8	false	myc tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P19357	uniprotkb:Q5U3Z7	intact:EBI-915426|uniprotkb:P97900|ensembl:ENSRNOP00000023256	intact:EBI-920554|ensembl:ENSRNOP00000011082	psi-mi:glut4_rat(display_long)|uniprotkb:Glucose transporter type 4, insulin-responsive(gene name synonym)|uniprotkb:Slc2a4(gene name)|psi-mi:Slc2a4(display_short)|uniprotkb:Glut4(gene name synonym)	psi-mi:q5u3z7_rat(display_long)|uniprotkb:Shmt2(gene name)|psi-mi:Shmt2(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Foster et al. (2006)	pubmed:16396496|mint:MINT-5218203	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-921030	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2711|refseq:NP_036883.1|refseq:XP_006246658.1|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007611"(learning or memory)|go:"GO:0007614"(short-term memory)|go:"GO:0007616"(long-term memory)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010021"(amylopectin biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031550"(positive regulation of brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044381"(glucose import in response to insulin stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046323"(glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0098694"(regulation of synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0098793"(presynapse)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002441("Glucose transporter, type 4 (GLUT4)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-189200|ensembl:ENSRNOG00000017226(gene)|ensembl:ENSRNOT00000023256(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)	rgd:1308582|refseq:NP_001008323.1|ensembl:ENSRNOG00000008106(gene)|ensembl:ENSRNOT00000011082(transcript)|go:"GO:0000900"(translation repressor activity, mRNA regulatory element binding)|go:"GO:0002082"(regulation of oxidative phosphorylation)|go:"GO:0003682"(chromatin binding)|go:"GO:0004372"(glycine hydroxymethyltransferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005829"(cytosol)|go:"GO:0006544"(glycine metabolic process)|go:"GO:0006545"(glycine biosynthetic process)|go:"GO:0006563"(L-serine metabolic process)|go:"GO:0006564"(L-serine biosynthetic process)|go:"GO:0006565"(L-serine catabolic process)|go:"GO:0006730"(one-carbon metabolic process)|go:"GO:0008168"(methyltransferase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008732"(L-allo-threonine aldolase activity)|go:"GO:0009113"(purine nucleobase biosynthetic process)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016597"(amino acid binding)|go:"GO:0019264"(glycine biosynthetic process from serine)|go:"GO:0030170"(pyridoxal phosphate binding)|go:"GO:0032259"(methylation)|go:"GO:0034340"(response to type I interferon)|go:"GO:0035999"(tetrahydrofolate interconversion)|go:"GO:0042645"(mitochondrial nucleoid)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0046653"(tetrahydrofolate metabolic process)|go:"GO:0046655"(folic acid metabolic process)|go:"GO:0048027"(mRNA 5'-UTR binding)|go:"GO:0050897"(cobalt ion binding)|go:"GO:0051262"(protein tetramerization)|go:"GO:0051289"(protein homotetramerization)|go:"GO:0070129"(regulation of mitochondrial translation)|go:"GO:0070536"(protein K63-linked deubiquitination)|go:"GO:0070552"(BRISC complex)|go:"GO:0070905"(serine binding)|go:"GO:1903715"(regulation of aerobic respiration)|interpro:IPR001085(Glycine hydroxymethyltransferase)|interpro:IPR015421(Pyridoxal phosphate-dependent transferase, major region, subdomain 1)|interpro:IPR015422(Pyridoxal phosphate-dependent transferase, major region, subdomain 2)|interpro:IPR015424(Pyridoxal phosphate-dependent transferase, major region)|interpro:IPR019798|interpro:IPR039429|reactome:R-RNO-196757|reactome:R-RNO-9013408	-	-	-	caution:"The participant EBI-349571(P68370) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919386(Q7TP47) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920972(Q5XIP9) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-916419(P11980) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919578(Q8R491) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920554(Q5U3Z7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920647(Q5U2X8) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920585(Q7TP24) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-779677(P05426) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-915744(P02454) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|agonist:Insulin was shown to increase or decrease GLUT4 protein interactions in specific cases.|comment:"Insulin decreased GLUT4 interactions with the following proteins: Q9ER30 (Sarcosin), P09527 (Rab-7), O88960 (N-ethylmaleimide sensitive), P09456 (PKA I regulatory subunit), P27881 (Hexokinase type II), P07872 (Acyl-coenzyme A oxidase), Q6DGF1 (Isocitrate dehydrogenase), Q9EQX9 (Ubiquitin-conjugating), Q63446 (Polyubiquitin), P24268 (Cathepsin D), Q91XW0 (Heat shock protein 86), Q5FVH0 (unknown), P58405 (Striatin 3), Q62667 (Major vault protein), Q66H50 (unknown), Q09167 (splicing factor), Q9JHU5 (Arfaptin 1)."|comment:"Insulin increased GLUT4 interaction with the following proteins:Q9Z1P2 (R-actinin-1), P45592 (Cofilin), Q9QXQ0 (R-actinin-4), P26473 (ADP-ribosylation factor), P26437 (ADP-ribosylation factor),   Q7TNP1 (Basigin 2), Q6P6R2 (Dihydrolipoamide dehydrogenase),   P04797 (GAPDH), Q63081 (Protein disulfide isomerase), P29457 (47 kDa heat shock protein), Q9R1J8 (Leprecan), O88638 (Putative eps protein),   Q64375 (Synaptonemal complex)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:NDPK - Interactions involving proteins containing InterPro domain IPR001564, Nucleoside diphosphate kinase, core.	taxid:10116(rat-l6)|taxid:10116(Rattus norvegicus)	-	2006/02/15	2021/11/30	rogid:PbFY2lfrty8yw40Jq7ShR7xfuV410116	rogid:3sKhF1GFt310wzUzeVGixgV+yfg10116	intact-crc:44F3A2176D02515F|rigid:9RVm0UBcqQF4k06RGKO89Bg16Q8	false	myc tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P19357	uniprotkb:Q32KJ5	intact:EBI-915426|uniprotkb:P97900|ensembl:ENSRNOP00000023256	intact:EBI-920546|ensembl:ENSRNOP00000006566|uniprotkb:F7F393	psi-mi:glut4_rat(display_long)|uniprotkb:Glucose transporter type 4, insulin-responsive(gene name synonym)|uniprotkb:Slc2a4(gene name)|psi-mi:Slc2a4(display_short)|uniprotkb:Glut4(gene name synonym)	psi-mi:q32kj5_rat(display_long)|uniprotkb:Gns(gene name)|psi-mi:Gns(display_short)|uniprotkb:LOC100909505(gene name synonym)|uniprotkb:Glucosamine-6-sulfatase(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Foster et al. (2006)	pubmed:16396496|mint:MINT-5218203	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-921030	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2711|refseq:NP_036883.1|refseq:XP_006246658.1|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007611"(learning or memory)|go:"GO:0007614"(short-term memory)|go:"GO:0007616"(long-term memory)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010021"(amylopectin biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031550"(positive regulation of brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044381"(glucose import in response to insulin stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046323"(glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0098694"(regulation of synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0098793"(presynapse)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002441("Glucose transporter, type 4 (GLUT4)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-189200|ensembl:ENSRNOG00000017226(gene)|ensembl:ENSRNOT00000023256(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)	rgd:6503308|refseq:XP_006241458.1|rgd:1305877|refseq:XP_003750373.1|go:"GO:0005539"(glycosaminoglycan binding)|go:"GO:0005764"(lysosome)|go:"GO:0008449"(N-acetylglucosamine-6-sulfatase activity)|ensembl:ENSRNOG00000046159(gene)|ensembl:ENSRNOT00000006566(transcript)|go:"GO:0008484"(sulfuric ester hydrolase activity)|go:"GO:0042340"(keratan sulfate catabolic process)|go:"GO:0043199"(sulfate binding)|go:"GO:0046872"(metal ion binding)|interpro:IPR000917(Sulphatase)|interpro:IPR012251(N-acetylglucosamine-6-sulphatase)|interpro:IPR015981(N-acetylglucosamine-6-sulphatase, eukaryotic)|interpro:IPR017850(Alkaline-phosphatase-like, core domain)|interpro:IPR024607|reactome:R-RNO-2022857|reactome:R-RNO-432720|reactome:R-RNO-6798695	-	-	-	caution:"The participant EBI-349571(P68370) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919386(Q7TP47) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920972(Q5XIP9) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-916419(P11980) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919578(Q8R491) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920554(Q5U3Z7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920647(Q5U2X8) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920585(Q7TP24) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-779677(P05426) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-915744(P02454) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|agonist:Insulin was shown to increase or decrease GLUT4 protein interactions in specific cases.|comment:"Insulin decreased GLUT4 interactions with the following proteins: Q9ER30 (Sarcosin), P09527 (Rab-7), O88960 (N-ethylmaleimide sensitive), P09456 (PKA I regulatory subunit), P27881 (Hexokinase type II), P07872 (Acyl-coenzyme A oxidase), Q6DGF1 (Isocitrate dehydrogenase), Q9EQX9 (Ubiquitin-conjugating), Q63446 (Polyubiquitin), P24268 (Cathepsin D), Q91XW0 (Heat shock protein 86), Q5FVH0 (unknown), P58405 (Striatin 3), Q62667 (Major vault protein), Q66H50 (unknown), Q09167 (splicing factor), Q9JHU5 (Arfaptin 1)."|comment:"Insulin increased GLUT4 interaction with the following proteins:Q9Z1P2 (R-actinin-1), P45592 (Cofilin), Q9QXQ0 (R-actinin-4), P26473 (ADP-ribosylation factor), P26437 (ADP-ribosylation factor),   Q7TNP1 (Basigin 2), Q6P6R2 (Dihydrolipoamide dehydrogenase),   P04797 (GAPDH), Q63081 (Protein disulfide isomerase), P29457 (47 kDa heat shock protein), Q9R1J8 (Leprecan), O88638 (Putative eps protein),   Q64375 (Synaptonemal complex)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:NDPK - Interactions involving proteins containing InterPro domain IPR001564, Nucleoside diphosphate kinase, core.	taxid:10116(rat-l6)|taxid:10116(Rattus norvegicus)	-	2006/02/15	2021/11/30	rogid:PbFY2lfrty8yw40Jq7ShR7xfuV410116	rogid:rG5/vftKxHPzea580ggbXKrA7Uk10116	intact-crc:44F3A2176D02515F|rigid:9RVm0UBcqQF4k06RGKO89Bg16Q8	false	myc tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P19357	uniprotkb:Q6AYH5	intact:EBI-915426|uniprotkb:P97900|ensembl:ENSRNOP00000023256	intact:EBI-920539|ensembl:ENSRNOP00000008120	psi-mi:glut4_rat(display_long)|uniprotkb:Glucose transporter type 4, insulin-responsive(gene name synonym)|uniprotkb:Slc2a4(gene name)|psi-mi:Slc2a4(display_short)|uniprotkb:Glut4(gene name synonym)	psi-mi:dctn2_rat(display_long)|uniprotkb:Dctn2(gene name)|psi-mi:Dctn2(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Foster et al. (2006)	pubmed:16396496|mint:MINT-5218203	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-921030	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2711|refseq:NP_036883.1|refseq:XP_006246658.1|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007611"(learning or memory)|go:"GO:0007614"(short-term memory)|go:"GO:0007616"(long-term memory)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010021"(amylopectin biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031550"(positive regulation of brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044381"(glucose import in response to insulin stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046323"(glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0098694"(regulation of synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0098793"(presynapse)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002441("Glucose transporter, type 4 (GLUT4)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-189200|ensembl:ENSRNOG00000017226(gene)|ensembl:ENSRNOT00000023256(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)	rgd:1303182|refseq:NP_001004239.1|ensembl:ENSRNOG00000025481(gene)|ensembl:ENSRNOT00000008120(transcript)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0000776"(kinetochore)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005869"(dynactin complex)|go:"GO:0005874"(microtubule)|go:"GO:0007052"(mitotic spindle organization)|go:"GO:0007080"(mitotic metaphase plate congression)|go:"GO:0016020"(membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030286"(dynein complex)|go:"GO:0030426"(growth cone)|go:"GO:0030507"(spectrin binding)|go:"GO:0031982"(vesicle)|go:"GO:0032402"(melanosome transport)|go:"GO:0042802"(identical protein binding)|go:"GO:0071539"(protein localization to centrosome)|interpro:IPR028133|mint:Q6AYH5|reactome:R-RNO-2132295|reactome:R-RNO-2565942|reactome:R-RNO-3371497|reactome:R-RNO-380259|reactome:R-RNO-380270|reactome:R-RNO-380284|reactome:R-RNO-380320|reactome:R-RNO-5620912|reactome:R-RNO-6807878|reactome:R-RNO-6811436|reactome:R-RNO-8854518	-	-	-	caution:"The participant EBI-349571(P68370) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919386(Q7TP47) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920972(Q5XIP9) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-916419(P11980) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919578(Q8R491) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920554(Q5U3Z7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920647(Q5U2X8) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920585(Q7TP24) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-779677(P05426) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-915744(P02454) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|agonist:Insulin was shown to increase or decrease GLUT4 protein interactions in specific cases.|comment:"Insulin decreased GLUT4 interactions with the following proteins: Q9ER30 (Sarcosin), P09527 (Rab-7), O88960 (N-ethylmaleimide sensitive), P09456 (PKA I regulatory subunit), P27881 (Hexokinase type II), P07872 (Acyl-coenzyme A oxidase), Q6DGF1 (Isocitrate dehydrogenase), Q9EQX9 (Ubiquitin-conjugating), Q63446 (Polyubiquitin), P24268 (Cathepsin D), Q91XW0 (Heat shock protein 86), Q5FVH0 (unknown), P58405 (Striatin 3), Q62667 (Major vault protein), Q66H50 (unknown), Q09167 (splicing factor), Q9JHU5 (Arfaptin 1)."|comment:"Insulin increased GLUT4 interaction with the following proteins:Q9Z1P2 (R-actinin-1), P45592 (Cofilin), Q9QXQ0 (R-actinin-4), P26473 (ADP-ribosylation factor), P26437 (ADP-ribosylation factor),   Q7TNP1 (Basigin 2), Q6P6R2 (Dihydrolipoamide dehydrogenase),   P04797 (GAPDH), Q63081 (Protein disulfide isomerase), P29457 (47 kDa heat shock protein), Q9R1J8 (Leprecan), O88638 (Putative eps protein),   Q64375 (Synaptonemal complex)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:NDPK - Interactions involving proteins containing InterPro domain IPR001564, Nucleoside diphosphate kinase, core.	taxid:10116(rat-l6)|taxid:10116(Rattus norvegicus)	-	2006/02/15	2021/11/30	rogid:PbFY2lfrty8yw40Jq7ShR7xfuV410116	rogid:B7LyMXi8DNGgOm+GDSigf2eHuE810116	intact-crc:44F3A2176D02515F|rigid:9RVm0UBcqQF4k06RGKO89Bg16Q8	false	myc tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P19357	uniprotkb:Q5M918	intact:EBI-915426|uniprotkb:P97900|ensembl:ENSRNOP00000023256	intact:EBI-920530	psi-mi:glut4_rat(display_long)|uniprotkb:Glucose transporter type 4, insulin-responsive(gene name synonym)|uniprotkb:Slc2a4(gene name)|psi-mi:Slc2a4(display_short)|uniprotkb:Glut4(gene name synonym)	psi-mi:q5m918_rat(display_long)|uniprotkb:Gns(gene name)|psi-mi:Gns(display_short)|uniprotkb:Glucosamine-6-sulfatase(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Foster et al. (2006)	pubmed:16396496|mint:MINT-5218203	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-921030	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2711|refseq:NP_036883.1|refseq:XP_006246658.1|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007611"(learning or memory)|go:"GO:0007614"(short-term memory)|go:"GO:0007616"(long-term memory)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010021"(amylopectin biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031550"(positive regulation of brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044381"(glucose import in response to insulin stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046323"(glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0098694"(regulation of synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0098793"(presynapse)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002441("Glucose transporter, type 4 (GLUT4)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-189200|ensembl:ENSRNOG00000017226(gene)|ensembl:ENSRNOT00000023256(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)	interpro:IPR015981(N-acetylglucosamine-6-sulphatase, eukaryotic)|rgd:1305877|refseq:NP_001011989.1|interpro:IPR017850(Alkaline-phosphatase-like, core domain)|interpro:IPR012251(N-acetylglucosamine-6-sulphatase)|interpro:IPR000917(Sulphatase)|interpro:IPR024607|go:"GO:0005539"(glycosaminoglycan binding)|go:"GO:0005764"(lysosome)|go:"GO:0008449"(N-acetylglucosamine-6-sulfatase activity)|go:"GO:0008484"(sulfuric ester hydrolase activity)|go:"GO:0042340"(keratan sulfate catabolic process)|go:"GO:0043199"(sulfate binding)|go:"GO:0046872"(metal ion binding)	-	-	-	caution:"The participant EBI-349571(P68370) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919386(Q7TP47) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920972(Q5XIP9) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-916419(P11980) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919578(Q8R491) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920554(Q5U3Z7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920647(Q5U2X8) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920585(Q7TP24) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-779677(P05426) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-915744(P02454) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|agonist:Insulin was shown to increase or decrease GLUT4 protein interactions in specific cases.|comment:"Insulin decreased GLUT4 interactions with the following proteins: Q9ER30 (Sarcosin), P09527 (Rab-7), O88960 (N-ethylmaleimide sensitive), P09456 (PKA I regulatory subunit), P27881 (Hexokinase type II), P07872 (Acyl-coenzyme A oxidase), Q6DGF1 (Isocitrate dehydrogenase), Q9EQX9 (Ubiquitin-conjugating), Q63446 (Polyubiquitin), P24268 (Cathepsin D), Q91XW0 (Heat shock protein 86), Q5FVH0 (unknown), P58405 (Striatin 3), Q62667 (Major vault protein), Q66H50 (unknown), Q09167 (splicing factor), Q9JHU5 (Arfaptin 1)."|comment:"Insulin increased GLUT4 interaction with the following proteins:Q9Z1P2 (R-actinin-1), P45592 (Cofilin), Q9QXQ0 (R-actinin-4), P26473 (ADP-ribosylation factor), P26437 (ADP-ribosylation factor),   Q7TNP1 (Basigin 2), Q6P6R2 (Dihydrolipoamide dehydrogenase),   P04797 (GAPDH), Q63081 (Protein disulfide isomerase), P29457 (47 kDa heat shock protein), Q9R1J8 (Leprecan), O88638 (Putative eps protein),   Q64375 (Synaptonemal complex)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:NDPK - Interactions involving proteins containing InterPro domain IPR001564, Nucleoside diphosphate kinase, core.	taxid:10116(rat-l6)|taxid:10116(Rattus norvegicus)	-	2006/02/15	2021/11/30	rogid:PbFY2lfrty8yw40Jq7ShR7xfuV410116	rogid:sDD9HayBfS2Yqsr44/6yoKJGKiM10116	intact-crc:44F3A2176D02515F|rigid:9RVm0UBcqQF4k06RGKO89Bg16Q8	false	myc tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P19357	uniprotkb:Q5XIM9	intact:EBI-915426|uniprotkb:P97900|ensembl:ENSRNOP00000023256	intact:EBI-920517|ensembl:ENSRNOP00000029234	psi-mi:glut4_rat(display_long)|uniprotkb:Glucose transporter type 4, insulin-responsive(gene name synonym)|uniprotkb:Slc2a4(gene name)|psi-mi:Slc2a4(display_short)|uniprotkb:Glut4(gene name synonym)	psi-mi:tcpb_rat(display_long)|uniprotkb:Cct2(gene name)|psi-mi:Cct2(display_short)|uniprotkb:CCT-beta(gene name synonym)|uniprotkb:Cctb(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Foster et al. (2006)	pubmed:16396496|mint:MINT-5218203	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-921030	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2711|refseq:NP_036883.1|refseq:XP_006246658.1|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007611"(learning or memory)|go:"GO:0007614"(short-term memory)|go:"GO:0007616"(long-term memory)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010021"(amylopectin biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031550"(positive regulation of brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044381"(glucose import in response to insulin stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046323"(glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0098694"(regulation of synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0098793"(presynapse)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002441("Glucose transporter, type 4 (GLUT4)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-189200|ensembl:ENSRNOG00000017226(gene)|ensembl:ENSRNOT00000023256(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)	rgd:1359143|refseq:NP_001005905.1|ensembl:ENSRNOG00000021317(gene)|ensembl:ENSRNOT00000037946(transcript)|go:"GO:0002199"(zona pellucida receptor complex)|go:"GO:0005524"(ATP binding)|go:"GO:0005832"(chaperonin-containing T-complex)|go:"GO:0005874"(microtubule)|go:"GO:0006457"(protein folding)|go:"GO:0007339"(binding of sperm to zona pellucida)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032212"(positive regulation of telomere maintenance via telomerase)|go:"GO:0044183"(protein folding chaperone)|go:"GO:0044297"(cell body)|go:"GO:0050821"(protein stabilization)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051086"(chaperone mediated protein folding independent of cofactor)|go:"GO:0051131"(chaperone-mediated protein complex assembly)|go:"GO:0051973"(positive regulation of telomerase activity)|go:"GO:0090666"(scaRNA localization to Cajal body)|go:"GO:1901998"(toxin transport)|go:"GO:1904851"(positive regulation of establishment of protein localization to telomere)|go:"GO:1904874"(positive regulation of telomerase RNA localization to Cajal body)|interpro:IPR002194(Chaperonin TCP-1, conserved site)|interpro:IPR002423(Chaperonin Cpn60/TCP-1)|interpro:IPR012716(T-complex protein 1, beta subunit)|interpro:IPR017998|interpro:IPR027409|interpro:IPR027410|interpro:IPR027413|mint:Q5XIM9|reactome:R-RNO-390471|reactome:R-RNO-5620922|reactome:R-RNO-6798695|reactome:R-RNO-6814122|reactome:R-RNO-9013418|reactome:R-RNO-9013422	-	-	-	caution:"The participant EBI-349571(P68370) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919386(Q7TP47) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920972(Q5XIP9) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-916419(P11980) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919578(Q8R491) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920554(Q5U3Z7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920647(Q5U2X8) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920585(Q7TP24) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-779677(P05426) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-915744(P02454) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|agonist:Insulin was shown to increase or decrease GLUT4 protein interactions in specific cases.|comment:"Insulin decreased GLUT4 interactions with the following proteins: Q9ER30 (Sarcosin), P09527 (Rab-7), O88960 (N-ethylmaleimide sensitive), P09456 (PKA I regulatory subunit), P27881 (Hexokinase type II), P07872 (Acyl-coenzyme A oxidase), Q6DGF1 (Isocitrate dehydrogenase), Q9EQX9 (Ubiquitin-conjugating), Q63446 (Polyubiquitin), P24268 (Cathepsin D), Q91XW0 (Heat shock protein 86), Q5FVH0 (unknown), P58405 (Striatin 3), Q62667 (Major vault protein), Q66H50 (unknown), Q09167 (splicing factor), Q9JHU5 (Arfaptin 1)."|comment:"Insulin increased GLUT4 interaction with the following proteins:Q9Z1P2 (R-actinin-1), P45592 (Cofilin), Q9QXQ0 (R-actinin-4), P26473 (ADP-ribosylation factor), P26437 (ADP-ribosylation factor),   Q7TNP1 (Basigin 2), Q6P6R2 (Dihydrolipoamide dehydrogenase),   P04797 (GAPDH), Q63081 (Protein disulfide isomerase), P29457 (47 kDa heat shock protein), Q9R1J8 (Leprecan), O88638 (Putative eps protein),   Q64375 (Synaptonemal complex)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:NDPK - Interactions involving proteins containing InterPro domain IPR001564, Nucleoside diphosphate kinase, core.	taxid:10116(rat-l6)|taxid:10116(Rattus norvegicus)	-	2006/02/15	2021/11/30	rogid:PbFY2lfrty8yw40Jq7ShR7xfuV410116	rogid:JKr4ca8SpJ/EnpoJsDazwn8L6hc10116	intact-crc:44F3A2176D02515F|rigid:9RVm0UBcqQF4k06RGKO89Bg16Q8	false	myc tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P19357	uniprotkb:Q5XIU4	intact:EBI-915426|uniprotkb:P97900|ensembl:ENSRNOP00000023256	intact:EBI-920507|ensembl:ENSRNOP00000010631	psi-mi:glut4_rat(display_long)|uniprotkb:Glucose transporter type 4, insulin-responsive(gene name synonym)|uniprotkb:Slc2a4(gene name)|psi-mi:Slc2a4(display_short)|uniprotkb:Glut4(gene name synonym)	psi-mi:q5xiu4_rat(display_long)|uniprotkb:Bcap29(gene name)|psi-mi:Bcap29(display_short)|uniprotkb:rCG_62391(orf name)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Foster et al. (2006)	pubmed:16396496|mint:MINT-5218203	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-921030	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2711|refseq:NP_036883.1|refseq:XP_006246658.1|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007611"(learning or memory)|go:"GO:0007614"(short-term memory)|go:"GO:0007616"(long-term memory)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010021"(amylopectin biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031550"(positive regulation of brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044381"(glucose import in response to insulin stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046323"(glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0098694"(regulation of synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0098793"(presynapse)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002441("Glucose transporter, type 4 (GLUT4)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-189200|ensembl:ENSRNOG00000017226(gene)|ensembl:ENSRNOT00000023256(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)	rgd:1359431|refseq:NP_001006981.1|refseq:XP_006240044.1|ensembl:ENSRNOG00000007884(gene)|ensembl:ENSRNOT00000010631(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006888"(endoplasmic reticulum to Golgi vesicle-mediated transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0070973"(protein localization to endoplasmic reticulum exit site)|interpro:IPR008417(B-cell receptor-associated 31-like)|interpro:IPR040463|interpro:IPR041672	-	-	-	caution:"The participant EBI-349571(P68370) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919386(Q7TP47) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920972(Q5XIP9) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-916419(P11980) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919578(Q8R491) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920554(Q5U3Z7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920647(Q5U2X8) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920585(Q7TP24) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-779677(P05426) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-915744(P02454) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|agonist:Insulin was shown to increase or decrease GLUT4 protein interactions in specific cases.|comment:"Insulin decreased GLUT4 interactions with the following proteins: Q9ER30 (Sarcosin), P09527 (Rab-7), O88960 (N-ethylmaleimide sensitive), P09456 (PKA I regulatory subunit), P27881 (Hexokinase type II), P07872 (Acyl-coenzyme A oxidase), Q6DGF1 (Isocitrate dehydrogenase), Q9EQX9 (Ubiquitin-conjugating), Q63446 (Polyubiquitin), P24268 (Cathepsin D), Q91XW0 (Heat shock protein 86), Q5FVH0 (unknown), P58405 (Striatin 3), Q62667 (Major vault protein), Q66H50 (unknown), Q09167 (splicing factor), Q9JHU5 (Arfaptin 1)."|comment:"Insulin increased GLUT4 interaction with the following proteins:Q9Z1P2 (R-actinin-1), P45592 (Cofilin), Q9QXQ0 (R-actinin-4), P26473 (ADP-ribosylation factor), P26437 (ADP-ribosylation factor),   Q7TNP1 (Basigin 2), Q6P6R2 (Dihydrolipoamide dehydrogenase),   P04797 (GAPDH), Q63081 (Protein disulfide isomerase), P29457 (47 kDa heat shock protein), Q9R1J8 (Leprecan), O88638 (Putative eps protein),   Q64375 (Synaptonemal complex)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:NDPK - Interactions involving proteins containing InterPro domain IPR001564, Nucleoside diphosphate kinase, core.	taxid:10116(rat-l6)|taxid:10116(Rattus norvegicus)	-	2006/02/15	2021/11/30	rogid:PbFY2lfrty8yw40Jq7ShR7xfuV410116	rogid:awdBmD3rYLoF26mN7zc3RzkZfEk10116	intact-crc:44F3A2176D02515F|rigid:9RVm0UBcqQF4k06RGKO89Bg16Q8	false	myc tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P19357	uniprotkb:Q3KRE0	intact:EBI-915426|uniprotkb:P97900|ensembl:ENSRNOP00000023256	intact:EBI-920489|ensembl:ENSRNOP00000046842	psi-mi:glut4_rat(display_long)|uniprotkb:Glucose transporter type 4, insulin-responsive(gene name synonym)|uniprotkb:Slc2a4(gene name)|psi-mi:Slc2a4(display_short)|uniprotkb:Glut4(gene name synonym)	psi-mi:atad3_rat(display_long)|uniprotkb:Atad3(gene name)|psi-mi:Atad3(display_short)|uniprotkb:Atad3a(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Foster et al. (2006)	pubmed:16396496|mint:MINT-5218203	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-921030	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2711|refseq:NP_036883.1|refseq:XP_006246658.1|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007611"(learning or memory)|go:"GO:0007614"(short-term memory)|go:"GO:0007616"(long-term memory)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010021"(amylopectin biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031550"(positive regulation of brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044381"(glucose import in response to insulin stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046323"(glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0098694"(regulation of synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0098793"(presynapse)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002441("Glucose transporter, type 4 (GLUT4)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-189200|ensembl:ENSRNOG00000017226(gene)|ensembl:ENSRNOT00000023256(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)	rgd:1305964|refseq:NP_001030094.1|ensembl:ENSRNOG00000018118(gene)|ensembl:ENSRNOT00000045053(transcript)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0005524"(ATP binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016021"(integral component of membrane)|go:"GO:0042645"(mitochondrial nucleoid)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0140374"(antiviral innate immune response)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR003959(AAA ATPase, core)|interpro:IPR021911|interpro:IPR027417|interpro:IPR039188|reactome:R-RNO-6798695	-	-	-	caution:"The participant EBI-349571(P68370) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919386(Q7TP47) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920972(Q5XIP9) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-916419(P11980) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919578(Q8R491) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920554(Q5U3Z7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920647(Q5U2X8) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920585(Q7TP24) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-779677(P05426) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-915744(P02454) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|agonist:Insulin was shown to increase or decrease GLUT4 protein interactions in specific cases.|comment:"Insulin decreased GLUT4 interactions with the following proteins: Q9ER30 (Sarcosin), P09527 (Rab-7), O88960 (N-ethylmaleimide sensitive), P09456 (PKA I regulatory subunit), P27881 (Hexokinase type II), P07872 (Acyl-coenzyme A oxidase), Q6DGF1 (Isocitrate dehydrogenase), Q9EQX9 (Ubiquitin-conjugating), Q63446 (Polyubiquitin), P24268 (Cathepsin D), Q91XW0 (Heat shock protein 86), Q5FVH0 (unknown), P58405 (Striatin 3), Q62667 (Major vault protein), Q66H50 (unknown), Q09167 (splicing factor), Q9JHU5 (Arfaptin 1)."|comment:"Insulin increased GLUT4 interaction with the following proteins:Q9Z1P2 (R-actinin-1), P45592 (Cofilin), Q9QXQ0 (R-actinin-4), P26473 (ADP-ribosylation factor), P26437 (ADP-ribosylation factor),   Q7TNP1 (Basigin 2), Q6P6R2 (Dihydrolipoamide dehydrogenase),   P04797 (GAPDH), Q63081 (Protein disulfide isomerase), P29457 (47 kDa heat shock protein), Q9R1J8 (Leprecan), O88638 (Putative eps protein),   Q64375 (Synaptonemal complex)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:NDPK - Interactions involving proteins containing InterPro domain IPR001564, Nucleoside diphosphate kinase, core.	taxid:10116(rat-l6)|taxid:10116(Rattus norvegicus)	-	2006/02/15	2021/11/30	rogid:PbFY2lfrty8yw40Jq7ShR7xfuV410116	rogid:08cOz7fL387Ek5/whjMlkiy/2AQ10116	intact-crc:44F3A2176D02515F|rigid:9RVm0UBcqQF4k06RGKO89Bg16Q8	false	myc tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P19357	uniprotkb:Q498E0	intact:EBI-915426|uniprotkb:P97900|ensembl:ENSRNOP00000023256	intact:EBI-920479|ensembl:ENSRNOP00000010700	psi-mi:glut4_rat(display_long)|uniprotkb:Glucose transporter type 4, insulin-responsive(gene name synonym)|uniprotkb:Slc2a4(gene name)|psi-mi:Slc2a4(display_short)|uniprotkb:Glut4(gene name synonym)	psi-mi:txd12_rat(display_long)|uniprotkb:Txndc12(gene name)|psi-mi:Txndc12(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Foster et al. (2006)	pubmed:16396496|mint:MINT-5218203	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-921030	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2711|refseq:NP_036883.1|refseq:XP_006246658.1|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007611"(learning or memory)|go:"GO:0007614"(short-term memory)|go:"GO:0007616"(long-term memory)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010021"(amylopectin biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031550"(positive regulation of brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044381"(glucose import in response to insulin stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046323"(glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0098694"(regulation of synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0098793"(presynapse)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002441("Glucose transporter, type 4 (GLUT4)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-189200|ensembl:ENSRNOG00000017226(gene)|ensembl:ENSRNOT00000023256(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)	rgd:1305960|refseq:NP_001094310.1|ensembl:ENSRNOG00000008090(gene)|ensembl:ENSRNOT00000010700(transcript)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0015035"(protein-disulfide reductase activity)|go:"GO:0019153"("protein-disulfide reductase (glutathione) activity")|go:"GO:0060548"(negative regulation of cell death)|go:"GO:1902236"(negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway)|interpro:IPR013766(Thioredoxin domain)|interpro:IPR017937|interpro:IPR036249|interpro:IPR037462	-	-	-	caution:"The participant EBI-349571(P68370) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919386(Q7TP47) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920972(Q5XIP9) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-916419(P11980) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919578(Q8R491) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920554(Q5U3Z7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920647(Q5U2X8) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920585(Q7TP24) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-779677(P05426) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-915744(P02454) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|agonist:Insulin was shown to increase or decrease GLUT4 protein interactions in specific cases.|comment:"Insulin decreased GLUT4 interactions with the following proteins: Q9ER30 (Sarcosin), P09527 (Rab-7), O88960 (N-ethylmaleimide sensitive), P09456 (PKA I regulatory subunit), P27881 (Hexokinase type II), P07872 (Acyl-coenzyme A oxidase), Q6DGF1 (Isocitrate dehydrogenase), Q9EQX9 (Ubiquitin-conjugating), Q63446 (Polyubiquitin), P24268 (Cathepsin D), Q91XW0 (Heat shock protein 86), Q5FVH0 (unknown), P58405 (Striatin 3), Q62667 (Major vault protein), Q66H50 (unknown), Q09167 (splicing factor), Q9JHU5 (Arfaptin 1)."|comment:"Insulin increased GLUT4 interaction with the following proteins:Q9Z1P2 (R-actinin-1), P45592 (Cofilin), Q9QXQ0 (R-actinin-4), P26473 (ADP-ribosylation factor), P26437 (ADP-ribosylation factor),   Q7TNP1 (Basigin 2), Q6P6R2 (Dihydrolipoamide dehydrogenase),   P04797 (GAPDH), Q63081 (Protein disulfide isomerase), P29457 (47 kDa heat shock protein), Q9R1J8 (Leprecan), O88638 (Putative eps protein),   Q64375 (Synaptonemal complex)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:NDPK - Interactions involving proteins containing InterPro domain IPR001564, Nucleoside diphosphate kinase, core.	taxid:10116(rat-l6)|taxid:10116(Rattus norvegicus)	-	2006/02/15	2021/11/30	rogid:PbFY2lfrty8yw40Jq7ShR7xfuV410116	rogid:yUungGuZpuckTlNTfnVAboluEqM10116	intact-crc:44F3A2176D02515F|rigid:9RVm0UBcqQF4k06RGKO89Bg16Q8	false	myc tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P19357	uniprotkb:Q4FZT0	intact:EBI-915426|uniprotkb:P97900|ensembl:ENSRNOP00000023256	intact:EBI-920472|ensembl:ENSRNOP00000013151	psi-mi:glut4_rat(display_long)|uniprotkb:Glucose transporter type 4, insulin-responsive(gene name synonym)|uniprotkb:Slc2a4(gene name)|psi-mi:Slc2a4(display_short)|uniprotkb:Glut4(gene name synonym)	psi-mi:stml2_rat(display_long)|uniprotkb:Stoml2(gene name)|psi-mi:Stoml2(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Foster et al. (2006)	pubmed:16396496|mint:MINT-5218203	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-921030	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2711|refseq:NP_036883.1|refseq:XP_006246658.1|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007611"(learning or memory)|go:"GO:0007614"(short-term memory)|go:"GO:0007616"(long-term memory)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010021"(amylopectin biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031550"(positive regulation of brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044381"(glucose import in response to insulin stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046323"(glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0098694"(regulation of synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0098793"(presynapse)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002441("Glucose transporter, type 4 (GLUT4)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-189200|ensembl:ENSRNOG00000017226(gene)|ensembl:ENSRNOT00000023256(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)	rgd:1308285|refseq:NP_001026816.1|ensembl:ENSRNOG00000009535(gene)|ensembl:ENSRNOT00000013151(transcript)|go:"GO:0001772"(immunological synapse)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0006851"(mitochondrial calcium ion transmembrane transport)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0008180"(COP9 signalosome)|go:"GO:0010876"(lipid localization)|go:"GO:0010918"(positive regulation of mitochondrial membrane potential)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0019897"(extrinsic component of plasma membrane)|go:"GO:0032743"(positive regulation of interleukin-2 production)|go:"GO:0034982"(mitochondrial protein processing)|go:"GO:0035710"(CD4-positive, alpha-beta T cell activation)|go:"GO:0042101"(T cell receptor complex)|go:"GO:0042776"(mitochondrial ATP synthesis coupled proton transport)|go:"GO:0045121"(membrane raft)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0051020"(GTPase binding)|go:"GO:0051259"(protein complex oligomerization)|go:"GO:0090297"(positive regulation of mitochondrial DNA replication)|go:"GO:1900210"(positive regulation of cardiolipin metabolic process)|go:"GO:1901612"(cardiolipin binding)|go:"GO:1990046"(stress-induced mitochondrial fusion)|interpro:IPR001107(Band 7 protein)|interpro:IPR001972(Stomatin)|interpro:IPR032435|interpro:IPR036013|mint:Q4FZT0|reactome:R-RNO-8949664	-	-	-	caution:"The participant EBI-349571(P68370) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919386(Q7TP47) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920972(Q5XIP9) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-916419(P11980) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919578(Q8R491) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920554(Q5U3Z7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920647(Q5U2X8) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920585(Q7TP24) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-779677(P05426) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-915744(P02454) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|agonist:Insulin was shown to increase or decrease GLUT4 protein interactions in specific cases.|comment:"Insulin decreased GLUT4 interactions with the following proteins: Q9ER30 (Sarcosin), P09527 (Rab-7), O88960 (N-ethylmaleimide sensitive), P09456 (PKA I regulatory subunit), P27881 (Hexokinase type II), P07872 (Acyl-coenzyme A oxidase), Q6DGF1 (Isocitrate dehydrogenase), Q9EQX9 (Ubiquitin-conjugating), Q63446 (Polyubiquitin), P24268 (Cathepsin D), Q91XW0 (Heat shock protein 86), Q5FVH0 (unknown), P58405 (Striatin 3), Q62667 (Major vault protein), Q66H50 (unknown), Q09167 (splicing factor), Q9JHU5 (Arfaptin 1)."|comment:"Insulin increased GLUT4 interaction with the following proteins:Q9Z1P2 (R-actinin-1), P45592 (Cofilin), Q9QXQ0 (R-actinin-4), P26473 (ADP-ribosylation factor), P26437 (ADP-ribosylation factor),   Q7TNP1 (Basigin 2), Q6P6R2 (Dihydrolipoamide dehydrogenase),   P04797 (GAPDH), Q63081 (Protein disulfide isomerase), P29457 (47 kDa heat shock protein), Q9R1J8 (Leprecan), O88638 (Putative eps protein),   Q64375 (Synaptonemal complex)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:NDPK - Interactions involving proteins containing InterPro domain IPR001564, Nucleoside diphosphate kinase, core.	taxid:10116(rat-l6)|taxid:10116(Rattus norvegicus)	-	2006/02/15	2021/11/30	rogid:PbFY2lfrty8yw40Jq7ShR7xfuV410116	rogid:tDZvRMTK92HMAD3z043Eb3hAKlI10116	intact-crc:44F3A2176D02515F|rigid:9RVm0UBcqQF4k06RGKO89Bg16Q8	false	myc tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P19357	uniprotkb:Q5XIG8	intact:EBI-915426|uniprotkb:P97900|ensembl:ENSRNOP00000023256	intact:EBI-920465|ensembl:ENSRNOP00000009923	psi-mi:glut4_rat(display_long)|uniprotkb:Glucose transporter type 4, insulin-responsive(gene name synonym)|uniprotkb:Slc2a4(gene name)|psi-mi:Slc2a4(display_short)|uniprotkb:Glut4(gene name synonym)	psi-mi:strap_rat(display_long)|uniprotkb:Strap(gene name)|psi-mi:Strap(display_short)|uniprotkb:UNR-interacting protein(gene name synonym)|uniprotkb:Unrip(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Foster et al. (2006)	pubmed:16396496|mint:MINT-5218203	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-921030	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2711|refseq:NP_036883.1|refseq:XP_006246658.1|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007611"(learning or memory)|go:"GO:0007614"(short-term memory)|go:"GO:0007616"(long-term memory)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010021"(amylopectin biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031550"(positive regulation of brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044381"(glucose import in response to insulin stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046323"(glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0098694"(regulation of synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0098793"(presynapse)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002441("Glucose transporter, type 4 (GLUT4)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-189200|ensembl:ENSRNOG00000017226(gene)|ensembl:ENSRNOT00000023256(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)	rgd:1311114|refseq:NP_001011969.1|ensembl:ENSRNOG00000007134(gene)|ensembl:ENSRNOT00000009923(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000380"(alternative mRNA splicing, via spliceosome)|go:"GO:0000387"(spliceosomal snRNP assembly)|go:"GO:0003723"(RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0004857"(enzyme inhibitor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0022618"(ribonucleoprotein complex assembly)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030277"(maintenance of gastrointestinal epithelium)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0032797"(SMN complex)|go:"GO:0034719"(SMN-Sm protein complex)|go:"GO:0048856"(anatomical structure development)|go:"GO:1990447"(U2 snRNP binding)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR020472|interpro:IPR036322|reactome:R-RNO-2173788	-	-	-	caution:"The participant EBI-349571(P68370) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919386(Q7TP47) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920972(Q5XIP9) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-916419(P11980) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919578(Q8R491) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920554(Q5U3Z7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920647(Q5U2X8) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920585(Q7TP24) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-779677(P05426) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-915744(P02454) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|agonist:Insulin was shown to increase or decrease GLUT4 protein interactions in specific cases.|comment:"Insulin decreased GLUT4 interactions with the following proteins: Q9ER30 (Sarcosin), P09527 (Rab-7), O88960 (N-ethylmaleimide sensitive), P09456 (PKA I regulatory subunit), P27881 (Hexokinase type II), P07872 (Acyl-coenzyme A oxidase), Q6DGF1 (Isocitrate dehydrogenase), Q9EQX9 (Ubiquitin-conjugating), Q63446 (Polyubiquitin), P24268 (Cathepsin D), Q91XW0 (Heat shock protein 86), Q5FVH0 (unknown), P58405 (Striatin 3), Q62667 (Major vault protein), Q66H50 (unknown), Q09167 (splicing factor), Q9JHU5 (Arfaptin 1)."|comment:"Insulin increased GLUT4 interaction with the following proteins:Q9Z1P2 (R-actinin-1), P45592 (Cofilin), Q9QXQ0 (R-actinin-4), P26473 (ADP-ribosylation factor), P26437 (ADP-ribosylation factor),   Q7TNP1 (Basigin 2), Q6P6R2 (Dihydrolipoamide dehydrogenase),   P04797 (GAPDH), Q63081 (Protein disulfide isomerase), P29457 (47 kDa heat shock protein), Q9R1J8 (Leprecan), O88638 (Putative eps protein),   Q64375 (Synaptonemal complex)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:NDPK - Interactions involving proteins containing InterPro domain IPR001564, Nucleoside diphosphate kinase, core.	taxid:10116(rat-l6)|taxid:10116(Rattus norvegicus)	-	2006/02/15	2021/11/30	rogid:PbFY2lfrty8yw40Jq7ShR7xfuV410116	rogid:D4FBCH8LSpftvAH4wRfmO9Pg92U10116	intact-crc:44F3A2176D02515F|rigid:9RVm0UBcqQF4k06RGKO89Bg16Q8	false	myc tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P19357	uniprotkb:Q4AEF8	intact:EBI-915426|uniprotkb:P97900|ensembl:ENSRNOP00000023256	intact:EBI-920458|ensembl:ENSRNOP00000016137	psi-mi:glut4_rat(display_long)|uniprotkb:Glucose transporter type 4, insulin-responsive(gene name synonym)|uniprotkb:Slc2a4(gene name)|psi-mi:Slc2a4(display_short)|uniprotkb:Glut4(gene name synonym)	psi-mi:copg1_rat(display_long)|uniprotkb:Copg1(gene name)|psi-mi:Copg1(display_short)|uniprotkb:Copg(gene name synonym)|uniprotkb:Gamma-1-coat protein(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Foster et al. (2006)	pubmed:16396496|mint:MINT-5218203	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-921030	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2711|refseq:NP_036883.1|refseq:XP_006246658.1|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007611"(learning or memory)|go:"GO:0007614"(short-term memory)|go:"GO:0007616"(long-term memory)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010021"(amylopectin biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031550"(positive regulation of brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044381"(glucose import in response to insulin stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046323"(glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0098694"(regulation of synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0098793"(presynapse)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002441("Glucose transporter, type 4 (GLUT4)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-189200|ensembl:ENSRNOG00000017226(gene)|ensembl:ENSRNOT00000023256(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)	rgd:1565292|refseq:NP_001026992.1|ensembl:ENSRNOG00000010474(gene)|ensembl:ENSRNOT00000016137(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005793"(endoplasmic reticulum-Golgi intermediate compartment)|go:"GO:0005829"(cytosol)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006888"(endoplasmic reticulum to Golgi vesicle-mediated transport)|go:"GO:0006891"(intra-Golgi vesicle-mediated transport)|go:"GO:0009306"(protein secretion)|go:"GO:0030126"(COPI vesicle coat)|go:"GO:0051683"(establishment of Golgi localization)|go:"GO:0072384"(organelle transport along microtubule)|interpro:IPR002553(Clathrin/coatomer adaptor, adaptin-like, N-terminal)|interpro:IPR009028(Clathrin/coatomer adaptor, adaptin-like, appendage, C-terminal subdomain)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR012295(Beta2-adaptin/TATA-box binding, C-terminal)|interpro:IPR013040(Coatomer, gamma subunit, appendage, Ig-like subdomain)|interpro:IPR013041(Clathrin/coatomer adaptor, adaptin-like, appendage, Ig-like subdomain)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR017106(Coatomer, gamma subunit)|interpro:IPR032154|interpro:IPR037067|mint:Q4AEF8|reactome:R-RNO-6807878|reactome:R-RNO-6811434	-	-	-	caution:"The participant EBI-349571(P68370) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919386(Q7TP47) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920972(Q5XIP9) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-916419(P11980) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919578(Q8R491) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920554(Q5U3Z7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920647(Q5U2X8) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920585(Q7TP24) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-779677(P05426) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-915744(P02454) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|agonist:Insulin was shown to increase or decrease GLUT4 protein interactions in specific cases.|comment:"Insulin decreased GLUT4 interactions with the following proteins: Q9ER30 (Sarcosin), P09527 (Rab-7), O88960 (N-ethylmaleimide sensitive), P09456 (PKA I regulatory subunit), P27881 (Hexokinase type II), P07872 (Acyl-coenzyme A oxidase), Q6DGF1 (Isocitrate dehydrogenase), Q9EQX9 (Ubiquitin-conjugating), Q63446 (Polyubiquitin), P24268 (Cathepsin D), Q91XW0 (Heat shock protein 86), Q5FVH0 (unknown), P58405 (Striatin 3), Q62667 (Major vault protein), Q66H50 (unknown), Q09167 (splicing factor), Q9JHU5 (Arfaptin 1)."|comment:"Insulin increased GLUT4 interaction with the following proteins:Q9Z1P2 (R-actinin-1), P45592 (Cofilin), Q9QXQ0 (R-actinin-4), P26473 (ADP-ribosylation factor), P26437 (ADP-ribosylation factor),   Q7TNP1 (Basigin 2), Q6P6R2 (Dihydrolipoamide dehydrogenase),   P04797 (GAPDH), Q63081 (Protein disulfide isomerase), P29457 (47 kDa heat shock protein), Q9R1J8 (Leprecan), O88638 (Putative eps protein),   Q64375 (Synaptonemal complex)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:NDPK - Interactions involving proteins containing InterPro domain IPR001564, Nucleoside diphosphate kinase, core.	taxid:10116(rat-l6)|taxid:10116(Rattus norvegicus)	-	2006/02/15	2021/11/30	rogid:PbFY2lfrty8yw40Jq7ShR7xfuV410116	rogid:C2bGIEDbgzh1LzRVPR9/z259Jy010116	intact-crc:44F3A2176D02515F|rigid:9RVm0UBcqQF4k06RGKO89Bg16Q8	false	myc tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P19357	uniprotkb:P81799	intact:EBI-915426|uniprotkb:P97900|ensembl:ENSRNOP00000023256	intact:EBI-920453|uniprotkb:Q32Q91|ensembl:ENSRNOP00000039247	psi-mi:glut4_rat(display_long)|uniprotkb:Glucose transporter type 4, insulin-responsive(gene name synonym)|uniprotkb:Slc2a4(gene name)|psi-mi:Slc2a4(display_short)|uniprotkb:Glut4(gene name synonym)	psi-mi:nagk_rat(display_long)|uniprotkb:Nagk(gene name)|psi-mi:Nagk(display_short)|uniprotkb:GlcNAc kinase(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Foster et al. (2006)	pubmed:16396496|mint:MINT-5218203	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-921030	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2711|refseq:NP_036883.1|refseq:XP_006246658.1|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007611"(learning or memory)|go:"GO:0007614"(short-term memory)|go:"GO:0007616"(long-term memory)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010021"(amylopectin biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031550"(positive regulation of brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044381"(glucose import in response to insulin stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046323"(glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0098694"(regulation of synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0098793"(presynapse)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002441("Glucose transporter, type 4 (GLUT4)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-189200|ensembl:ENSRNOG00000017226(gene)|ensembl:ENSRNOT00000023256(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)	rgd:1305057|refseq:NP_001032857.1|ensembl:ENSRNOG00000013911(gene)|ensembl:ENSRNOT00000042875(transcript)|go:"GO:0005524"(ATP binding)|go:"GO:0006044"(N-acetylglucosamine metabolic process)|go:"GO:0009384"(N-acylmannosamine kinase activity)|go:"GO:0019262"(N-acetylneuraminate catabolic process)|go:"GO:0045127"(N-acetylglucosamine kinase activity)|interpro:IPR002731(ATPase, BadF/BadG/BcrA/BcrD type)|interpro:IPR039758|interpro:IPR043129|reactome:R-RNO-446210	-	-	-	caution:"The participant EBI-349571(P68370) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919386(Q7TP47) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920972(Q5XIP9) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-916419(P11980) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919578(Q8R491) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920554(Q5U3Z7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920647(Q5U2X8) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920585(Q7TP24) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-779677(P05426) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-915744(P02454) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|agonist:Insulin was shown to increase or decrease GLUT4 protein interactions in specific cases.|comment:"Insulin decreased GLUT4 interactions with the following proteins: Q9ER30 (Sarcosin), P09527 (Rab-7), O88960 (N-ethylmaleimide sensitive), P09456 (PKA I regulatory subunit), P27881 (Hexokinase type II), P07872 (Acyl-coenzyme A oxidase), Q6DGF1 (Isocitrate dehydrogenase), Q9EQX9 (Ubiquitin-conjugating), Q63446 (Polyubiquitin), P24268 (Cathepsin D), Q91XW0 (Heat shock protein 86), Q5FVH0 (unknown), P58405 (Striatin 3), Q62667 (Major vault protein), Q66H50 (unknown), Q09167 (splicing factor), Q9JHU5 (Arfaptin 1)."|comment:"Insulin increased GLUT4 interaction with the following proteins:Q9Z1P2 (R-actinin-1), P45592 (Cofilin), Q9QXQ0 (R-actinin-4), P26473 (ADP-ribosylation factor), P26437 (ADP-ribosylation factor),   Q7TNP1 (Basigin 2), Q6P6R2 (Dihydrolipoamide dehydrogenase),   P04797 (GAPDH), Q63081 (Protein disulfide isomerase), P29457 (47 kDa heat shock protein), Q9R1J8 (Leprecan), O88638 (Putative eps protein),   Q64375 (Synaptonemal complex)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:NDPK - Interactions involving proteins containing InterPro domain IPR001564, Nucleoside diphosphate kinase, core.	taxid:10116(rat-l6)|taxid:10116(Rattus norvegicus)	-	2006/02/15	2021/11/30	rogid:PbFY2lfrty8yw40Jq7ShR7xfuV410116	rogid:6hNuJCp+KThkHZe31g48Ce8J7h410116	intact-crc:44F3A2176D02515F|rigid:9RVm0UBcqQF4k06RGKO89Bg16Q8	false	myc tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P19357	uniprotkb:Q66H94	intact:EBI-915426|uniprotkb:P97900|ensembl:ENSRNOP00000023256	intact:EBI-920445|ensembl:ENSRNOP00000007821	psi-mi:glut4_rat(display_long)|uniprotkb:Glucose transporter type 4, insulin-responsive(gene name synonym)|uniprotkb:Slc2a4(gene name)|psi-mi:Slc2a4(display_short)|uniprotkb:Glut4(gene name synonym)	psi-mi:fkbp9_rat(display_long)|uniprotkb:Fkbp9(gene name)|psi-mi:Fkbp9(display_short)|uniprotkb:FK506-binding protein 9(gene name synonym)|uniprotkb:Rotamase(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Foster et al. (2006)	pubmed:16396496|mint:MINT-5218203	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-921030	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2711|refseq:NP_036883.1|refseq:XP_006246658.1|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007611"(learning or memory)|go:"GO:0007614"(short-term memory)|go:"GO:0007616"(long-term memory)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010021"(amylopectin biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031550"(positive regulation of brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044381"(glucose import in response to insulin stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046323"(glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0098694"(regulation of synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0098793"(presynapse)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002441("Glucose transporter, type 4 (GLUT4)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-189200|ensembl:ENSRNOG00000017226(gene)|ensembl:ENSRNOT00000023256(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)	rgd:1549757|refseq:NP_001007647.1|ensembl:ENSRNOG00000005478(gene)|ensembl:ENSRNOT00000007821(transcript)|go:"GO:0003755"(peptidyl-prolyl cis-trans isomerase activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0006457"(protein folding)|interpro:IPR001179(Peptidyl-prolyl cis-trans isomerase, FKBP-type)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR011992(EF-Hand type)|interpro:IPR018247	-	-	-	caution:"The participant EBI-349571(P68370) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919386(Q7TP47) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920972(Q5XIP9) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-916419(P11980) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919578(Q8R491) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920554(Q5U3Z7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920647(Q5U2X8) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920585(Q7TP24) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-779677(P05426) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-915744(P02454) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|agonist:Insulin was shown to increase or decrease GLUT4 protein interactions in specific cases.|comment:"Insulin decreased GLUT4 interactions with the following proteins: Q9ER30 (Sarcosin), P09527 (Rab-7), O88960 (N-ethylmaleimide sensitive), P09456 (PKA I regulatory subunit), P27881 (Hexokinase type II), P07872 (Acyl-coenzyme A oxidase), Q6DGF1 (Isocitrate dehydrogenase), Q9EQX9 (Ubiquitin-conjugating), Q63446 (Polyubiquitin), P24268 (Cathepsin D), Q91XW0 (Heat shock protein 86), Q5FVH0 (unknown), P58405 (Striatin 3), Q62667 (Major vault protein), Q66H50 (unknown), Q09167 (splicing factor), Q9JHU5 (Arfaptin 1)."|comment:"Insulin increased GLUT4 interaction with the following proteins:Q9Z1P2 (R-actinin-1), P45592 (Cofilin), Q9QXQ0 (R-actinin-4), P26473 (ADP-ribosylation factor), P26437 (ADP-ribosylation factor),   Q7TNP1 (Basigin 2), Q6P6R2 (Dihydrolipoamide dehydrogenase),   P04797 (GAPDH), Q63081 (Protein disulfide isomerase), P29457 (47 kDa heat shock protein), Q9R1J8 (Leprecan), O88638 (Putative eps protein),   Q64375 (Synaptonemal complex)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:NDPK - Interactions involving proteins containing InterPro domain IPR001564, Nucleoside diphosphate kinase, core.	taxid:10116(rat-l6)|taxid:10116(Rattus norvegicus)	-	2006/02/15	2021/11/30	rogid:PbFY2lfrty8yw40Jq7ShR7xfuV410116	rogid:S4fNzCFNY5CjhePPxmi0BFcQ+7Q10116	intact-crc:44F3A2176D02515F|rigid:9RVm0UBcqQF4k06RGKO89Bg16Q8	false	myc tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P19357	uniprotkb:Q5XI04	intact:EBI-915426|uniprotkb:P97900|ensembl:ENSRNOP00000023256	intact:EBI-920438|ensembl:ENSRNOP00000025904	psi-mi:glut4_rat(display_long)|uniprotkb:Glucose transporter type 4, insulin-responsive(gene name synonym)|uniprotkb:Slc2a4(gene name)|psi-mi:Slc2a4(display_short)|uniprotkb:Glut4(gene name synonym)	psi-mi:q5xi04_rat(display_long)|uniprotkb:Stom(gene name)|psi-mi:Stom(display_short)|uniprotkb:rCG_45489(orf name)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Foster et al. (2006)	pubmed:16396496|mint:MINT-5218203	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-921030	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2711|refseq:NP_036883.1|refseq:XP_006246658.1|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007611"(learning or memory)|go:"GO:0007614"(short-term memory)|go:"GO:0007616"(long-term memory)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010021"(amylopectin biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031550"(positive regulation of brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044381"(glucose import in response to insulin stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046323"(glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0098694"(regulation of synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0098793"(presynapse)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002441("Glucose transporter, type 4 (GLUT4)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-189200|ensembl:ENSRNOG00000017226(gene)|ensembl:ENSRNOT00000023256(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)	rgd:1305109|refseq:NP_001011965.1|reactome:R-RNO-9013148|reactome:R-RNO-9013406|reactome:R-RNO-9013407|ensembl:ENSRNOG00000019147(gene)|ensembl:ENSRNOT00000025904(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0034765"(regulation of ion transmembrane transport)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0044829"(positive regulation by host of viral genome replication)|go:"GO:0045121"(membrane raft)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048524"(positive regulation of viral process)|go:"GO:0070063"(RNA polymerase binding)|go:"GO:0090314"(positive regulation of protein targeting to membrane)|go:"GO:1901585"(regulation of acid-sensing ion channel activity)|interpro:IPR001107(Band 7 protein)|interpro:IPR001972(Stomatin)|interpro:IPR018080|interpro:IPR028515|interpro:IPR036013|interpro:IPR043202|reactome:R-RNO-2672351|reactome:R-RNO-6798695|reactome:R-RNO-8980692|reactome:R-RNO-9013026|reactome:R-RNO-9013106	-	-	-	caution:"The participant EBI-349571(P68370) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919386(Q7TP47) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920972(Q5XIP9) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-916419(P11980) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919578(Q8R491) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920554(Q5U3Z7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920647(Q5U2X8) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920585(Q7TP24) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-779677(P05426) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-915744(P02454) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|agonist:Insulin was shown to increase or decrease GLUT4 protein interactions in specific cases.|comment:"Insulin decreased GLUT4 interactions with the following proteins: Q9ER30 (Sarcosin), P09527 (Rab-7), O88960 (N-ethylmaleimide sensitive), P09456 (PKA I regulatory subunit), P27881 (Hexokinase type II), P07872 (Acyl-coenzyme A oxidase), Q6DGF1 (Isocitrate dehydrogenase), Q9EQX9 (Ubiquitin-conjugating), Q63446 (Polyubiquitin), P24268 (Cathepsin D), Q91XW0 (Heat shock protein 86), Q5FVH0 (unknown), P58405 (Striatin 3), Q62667 (Major vault protein), Q66H50 (unknown), Q09167 (splicing factor), Q9JHU5 (Arfaptin 1)."|comment:"Insulin increased GLUT4 interaction with the following proteins:Q9Z1P2 (R-actinin-1), P45592 (Cofilin), Q9QXQ0 (R-actinin-4), P26473 (ADP-ribosylation factor), P26437 (ADP-ribosylation factor),   Q7TNP1 (Basigin 2), Q6P6R2 (Dihydrolipoamide dehydrogenase),   P04797 (GAPDH), Q63081 (Protein disulfide isomerase), P29457 (47 kDa heat shock protein), Q9R1J8 (Leprecan), O88638 (Putative eps protein),   Q64375 (Synaptonemal complex)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:NDPK - Interactions involving proteins containing InterPro domain IPR001564, Nucleoside diphosphate kinase, core.	taxid:10116(rat-l6)|taxid:10116(Rattus norvegicus)	-	2006/02/15	2021/11/30	rogid:PbFY2lfrty8yw40Jq7ShR7xfuV410116	rogid:Ai+pEbCi38ku1lAXnWW+NJxVcig10116	intact-crc:44F3A2176D02515F|rigid:9RVm0UBcqQF4k06RGKO89Bg16Q8	false	myc tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P19357	uniprotkb:Q6AYS3	intact:EBI-915426|uniprotkb:P97900|ensembl:ENSRNOP00000023256	intact:EBI-920422|ensembl:ENSRNOP00000062425	psi-mi:glut4_rat(display_long)|uniprotkb:Glucose transporter type 4, insulin-responsive(gene name synonym)|uniprotkb:Slc2a4(gene name)|psi-mi:Slc2a4(display_short)|uniprotkb:Glut4(gene name synonym)	psi-mi:q6ays3_rat(display_long)|uniprotkb:Ctsa(gene name)|psi-mi:Ctsa(display_short)|uniprotkb:Ppgb(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Foster et al. (2006)	pubmed:16396496|mint:MINT-5218203	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-921030	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2711|refseq:NP_036883.1|refseq:XP_006246658.1|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007611"(learning or memory)|go:"GO:0007614"(short-term memory)|go:"GO:0007616"(long-term memory)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010021"(amylopectin biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031550"(positive regulation of brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044381"(glucose import in response to insulin stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046323"(glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0098694"(regulation of synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0098793"(presynapse)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002441("Glucose transporter, type 4 (GLUT4)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-189200|ensembl:ENSRNOG00000017226(gene)|ensembl:ENSRNOT00000023256(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)	rgd:1309070|ensembl:ENSRNOG00000015857(gene)|ensembl:ENSRNOT00000066028(transcript)|go:"GO:0004185"(serine-type carboxypeptidase activity)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0006508"(proteolysis)|go:"GO:0031647"(regulation of protein stability)|go:"GO:1904715"(negative regulation of chaperone-mediated autophagy)|interpro:IPR001563(Peptidase S10, serine carboxypeptidase)|interpro:IPR018202|interpro:IPR029058|reactome:R-RNO-1660662|reactome:R-RNO-2132295|reactome:R-RNO-4085001|reactome:R-RNO-6798695	-	-	-	caution:"The participant EBI-349571(P68370) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919386(Q7TP47) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920972(Q5XIP9) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-916419(P11980) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919578(Q8R491) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920554(Q5U3Z7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920647(Q5U2X8) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920585(Q7TP24) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-779677(P05426) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-915744(P02454) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|agonist:Insulin was shown to increase or decrease GLUT4 protein interactions in specific cases.|comment:"Insulin decreased GLUT4 interactions with the following proteins: Q9ER30 (Sarcosin), P09527 (Rab-7), O88960 (N-ethylmaleimide sensitive), P09456 (PKA I regulatory subunit), P27881 (Hexokinase type II), P07872 (Acyl-coenzyme A oxidase), Q6DGF1 (Isocitrate dehydrogenase), Q9EQX9 (Ubiquitin-conjugating), Q63446 (Polyubiquitin), P24268 (Cathepsin D), Q91XW0 (Heat shock protein 86), Q5FVH0 (unknown), P58405 (Striatin 3), Q62667 (Major vault protein), Q66H50 (unknown), Q09167 (splicing factor), Q9JHU5 (Arfaptin 1)."|comment:"Insulin increased GLUT4 interaction with the following proteins:Q9Z1P2 (R-actinin-1), P45592 (Cofilin), Q9QXQ0 (R-actinin-4), P26473 (ADP-ribosylation factor), P26437 (ADP-ribosylation factor),   Q7TNP1 (Basigin 2), Q6P6R2 (Dihydrolipoamide dehydrogenase),   P04797 (GAPDH), Q63081 (Protein disulfide isomerase), P29457 (47 kDa heat shock protein), Q9R1J8 (Leprecan), O88638 (Putative eps protein),   Q64375 (Synaptonemal complex)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:NDPK - Interactions involving proteins containing InterPro domain IPR001564, Nucleoside diphosphate kinase, core.	taxid:10116(rat-l6)|taxid:10116(Rattus norvegicus)	-	2006/02/15	2021/11/30	rogid:PbFY2lfrty8yw40Jq7ShR7xfuV410116	rogid:H5Je4yV177+07G/y14JHxkttqtc10116	intact-crc:44F3A2176D02515F|rigid:9RVm0UBcqQF4k06RGKO89Bg16Q8	false	myc tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P19357	uniprotkb:Q3MIE7	intact:EBI-915426|uniprotkb:P97900|ensembl:ENSRNOP00000023256	intact:EBI-920417|ensembl:ENSRNOP00000006628|ensembl:ENSRNOP00000070509	psi-mi:glut4_rat(display_long)|uniprotkb:Glucose transporter type 4, insulin-responsive(gene name synonym)|uniprotkb:Slc2a4(gene name)|psi-mi:Slc2a4(display_short)|uniprotkb:Glut4(gene name synonym)	psi-mi:q3mie7_rat(display_long)|uniprotkb:Commd9(gene name)|psi-mi:Commd9(display_short)|uniprotkb:rCG_26577(orf name)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Foster et al. (2006)	pubmed:16396496|mint:MINT-5218203	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-921030	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2711|refseq:NP_036883.1|refseq:XP_006246658.1|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007611"(learning or memory)|go:"GO:0007614"(short-term memory)|go:"GO:0007616"(long-term memory)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010021"(amylopectin biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031550"(positive regulation of brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044381"(glucose import in response to insulin stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046323"(glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0098694"(regulation of synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0098793"(presynapse)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002441("Glucose transporter, type 4 (GLUT4)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-189200|ensembl:ENSRNOG00000017226(gene)|ensembl:ENSRNOT00000023256(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)	rgd:1307706|refseq:NP_001028864.1|refseq:XP_006234699.1|ensembl:ENSRNOG00000004755(gene)|ensembl:ENSRNOT00000006628(transcript)|ensembl:ENSRNOT00000081984(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0042632"(cholesterol homeostasis)|interpro:IPR017920|interpro:IPR037360|reactome:R-RNO-6798695|reactome:R-RNO-8951664	-	-	-	caution:"The participant EBI-349571(P68370) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919386(Q7TP47) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920972(Q5XIP9) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-916419(P11980) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919578(Q8R491) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920554(Q5U3Z7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920647(Q5U2X8) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920585(Q7TP24) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-779677(P05426) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-915744(P02454) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|agonist:Insulin was shown to increase or decrease GLUT4 protein interactions in specific cases.|comment:"Insulin decreased GLUT4 interactions with the following proteins: Q9ER30 (Sarcosin), P09527 (Rab-7), O88960 (N-ethylmaleimide sensitive), P09456 (PKA I regulatory subunit), P27881 (Hexokinase type II), P07872 (Acyl-coenzyme A oxidase), Q6DGF1 (Isocitrate dehydrogenase), Q9EQX9 (Ubiquitin-conjugating), Q63446 (Polyubiquitin), P24268 (Cathepsin D), Q91XW0 (Heat shock protein 86), Q5FVH0 (unknown), P58405 (Striatin 3), Q62667 (Major vault protein), Q66H50 (unknown), Q09167 (splicing factor), Q9JHU5 (Arfaptin 1)."|comment:"Insulin increased GLUT4 interaction with the following proteins:Q9Z1P2 (R-actinin-1), P45592 (Cofilin), Q9QXQ0 (R-actinin-4), P26473 (ADP-ribosylation factor), P26437 (ADP-ribosylation factor),   Q7TNP1 (Basigin 2), Q6P6R2 (Dihydrolipoamide dehydrogenase),   P04797 (GAPDH), Q63081 (Protein disulfide isomerase), P29457 (47 kDa heat shock protein), Q9R1J8 (Leprecan), O88638 (Putative eps protein),   Q64375 (Synaptonemal complex)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:NDPK - Interactions involving proteins containing InterPro domain IPR001564, Nucleoside diphosphate kinase, core.	taxid:10116(rat-l6)|taxid:10116(Rattus norvegicus)	-	2006/02/15	2021/11/30	rogid:PbFY2lfrty8yw40Jq7ShR7xfuV410116	rogid:6XDyely1jl/I9bvaWbcw3yIaEUg10116	intact-crc:44F3A2176D02515F|rigid:9RVm0UBcqQF4k06RGKO89Bg16Q8	false	myc tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P19357	uniprotkb:Q68FT4	intact:EBI-915426|uniprotkb:P97900|ensembl:ENSRNOP00000023256	intact:EBI-920977	psi-mi:glut4_rat(display_long)|uniprotkb:Glucose transporter type 4, insulin-responsive(gene name synonym)|uniprotkb:Slc2a4(gene name)|psi-mi:Slc2a4(display_short)|uniprotkb:Glut4(gene name synonym)	psi-mi:q68ft4_rat(display_long)|uniprotkb:Suclg2(gene name)|psi-mi:Suclg2(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Foster et al. (2006)	pubmed:16396496|mint:MINT-5218203	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-921030	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2711|refseq:NP_036883.1|refseq:XP_006246658.1|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007611"(learning or memory)|go:"GO:0007614"(short-term memory)|go:"GO:0007616"(long-term memory)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010021"(amylopectin biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031550"(positive regulation of brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044381"(glucose import in response to insulin stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046323"(glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0098694"(regulation of synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0098793"(presynapse)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002441("Glucose transporter, type 4 (GLUT4)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-189200|ensembl:ENSRNOG00000017226(gene)|ensembl:ENSRNOT00000023256(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)	interpro:IPR011761(ATP-grasp fold)|interpro:IPR013650(ATP-grasp fold, succinyl-CoA synthetase-type)|interpro:IPR013815(ATP-grasp fold, subdomain 1)|interpro:IPR005811(ATP-citrate lyase/succinyl-CoA ligase)|interpro:IPR017866|interpro:IPR005809(Succinyl-CoA synthetase, beta subunit)|interpro:IPR016102(Succinyl-CoA synthetase-like)|interpro:IPR034722|go:"GO:0004776"("succinate-CoA ligase (GDP-forming) activity")|go:"GO:0005524"(ATP binding)|go:"GO:0005525"(GTP binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0006099"(tricarboxylic acid cycle)|go:"GO:0006104"(succinyl-CoA metabolic process)|go:"GO:0046872"(metal ion binding)	-	-	-	caution:"The participant EBI-349571(P68370) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919386(Q7TP47) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920972(Q5XIP9) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-916419(P11980) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919578(Q8R491) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920554(Q5U3Z7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920647(Q5U2X8) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920585(Q7TP24) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-779677(P05426) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-915744(P02454) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|agonist:Insulin was shown to increase or decrease GLUT4 protein interactions in specific cases.|comment:"Insulin decreased GLUT4 interactions with the following proteins: Q9ER30 (Sarcosin), P09527 (Rab-7), O88960 (N-ethylmaleimide sensitive), P09456 (PKA I regulatory subunit), P27881 (Hexokinase type II), P07872 (Acyl-coenzyme A oxidase), Q6DGF1 (Isocitrate dehydrogenase), Q9EQX9 (Ubiquitin-conjugating), Q63446 (Polyubiquitin), P24268 (Cathepsin D), Q91XW0 (Heat shock protein 86), Q5FVH0 (unknown), P58405 (Striatin 3), Q62667 (Major vault protein), Q66H50 (unknown), Q09167 (splicing factor), Q9JHU5 (Arfaptin 1)."|comment:"Insulin increased GLUT4 interaction with the following proteins:Q9Z1P2 (R-actinin-1), P45592 (Cofilin), Q9QXQ0 (R-actinin-4), P26473 (ADP-ribosylation factor), P26437 (ADP-ribosylation factor),   Q7TNP1 (Basigin 2), Q6P6R2 (Dihydrolipoamide dehydrogenase),   P04797 (GAPDH), Q63081 (Protein disulfide isomerase), P29457 (47 kDa heat shock protein), Q9R1J8 (Leprecan), O88638 (Putative eps protein),   Q64375 (Synaptonemal complex)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:NDPK - Interactions involving proteins containing InterPro domain IPR001564, Nucleoside diphosphate kinase, core.	taxid:10116(rat-l6)|taxid:10116(Rattus norvegicus)	-	2006/02/15	2021/11/30	rogid:PbFY2lfrty8yw40Jq7ShR7xfuV410116	rogid:5BsfiemHi+aEb7Beth4owI44ERs10116	intact-crc:44F3A2176D02515F|rigid:9RVm0UBcqQF4k06RGKO89Bg16Q8	false	myc tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P19357	uniprotkb:P68511	intact:EBI-915426|uniprotkb:P97900|ensembl:ENSRNOP00000023256	intact:EBI-444647|uniprotkb:P11576|uniprotkb:P70198|ensembl:ENSRNOP00000075701	psi-mi:glut4_rat(display_long)|uniprotkb:Glucose transporter type 4, insulin-responsive(gene name synonym)|uniprotkb:Slc2a4(gene name)|psi-mi:Slc2a4(display_short)|uniprotkb:Glut4(gene name synonym)	psi-mi:1433f_rat(display_long)|uniprotkb:Ywhah(gene name)|psi-mi:Ywhah(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Foster et al. (2006)	pubmed:16396496|mint:MINT-5218203	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-921030	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2711|refseq:NP_036883.1|refseq:XP_006246658.1|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007611"(learning or memory)|go:"GO:0007614"(short-term memory)|go:"GO:0007616"(long-term memory)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010021"(amylopectin biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031550"(positive regulation of brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044381"(glucose import in response to insulin stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046323"(glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0098694"(regulation of synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0098793"(presynapse)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002441("Glucose transporter, type 4 (GLUT4)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-189200|ensembl:ENSRNOG00000017226(gene)|ensembl:ENSRNOT00000023256(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)	rgd:3978|refseq:NP_037184.1|reactome:R-RNO-5628897|reactome:R-RNO-75035|reactome:R-RNO-5625740|go:"GO:0006886"(intracellular protein transport)|go:"GO:0017080"(sodium channel regulator activity)|go:"GO:0019899"(enzyme binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0035259"(glucocorticoid receptor binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0042921"(glucocorticoid receptor signaling pathway)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0045202"(synapse)|ensembl:ENSRNOG00000055471(gene)|ensembl:ENSRNOT00000085735(transcript)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0002028"(regulation of sodium ion transport)|go:"GO:0003779"(actin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0050774"(negative regulation of dendrite morphogenesis)|go:"GO:0005886"(plasma membrane)|go:"GO:0006713"(glucocorticoid catabolic process)|go:"GO:0086010"(membrane depolarization during action potential)|go:"GO:0098793"(presynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:2000649"(regulation of sodium ion transmembrane transporter activity)|interpro:IPR000308(14-3-3 protein)|interpro:IPR023409|interpro:IPR023410|interpro:IPR036815|mint:P68511|reactome:R-RNO-111447|dip:DIP-299N	-	-	-	caution:"The participant EBI-349571(P68370) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919386(Q7TP47) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920972(Q5XIP9) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-916419(P11980) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919578(Q8R491) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920554(Q5U3Z7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920647(Q5U2X8) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920585(Q7TP24) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-779677(P05426) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-915744(P02454) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|agonist:Insulin was shown to increase or decrease GLUT4 protein interactions in specific cases.|comment:"Insulin decreased GLUT4 interactions with the following proteins: Q9ER30 (Sarcosin), P09527 (Rab-7), O88960 (N-ethylmaleimide sensitive), P09456 (PKA I regulatory subunit), P27881 (Hexokinase type II), P07872 (Acyl-coenzyme A oxidase), Q6DGF1 (Isocitrate dehydrogenase), Q9EQX9 (Ubiquitin-conjugating), Q63446 (Polyubiquitin), P24268 (Cathepsin D), Q91XW0 (Heat shock protein 86), Q5FVH0 (unknown), P58405 (Striatin 3), Q62667 (Major vault protein), Q66H50 (unknown), Q09167 (splicing factor), Q9JHU5 (Arfaptin 1)."|comment:"Insulin increased GLUT4 interaction with the following proteins:Q9Z1P2 (R-actinin-1), P45592 (Cofilin), Q9QXQ0 (R-actinin-4), P26473 (ADP-ribosylation factor), P26437 (ADP-ribosylation factor),   Q7TNP1 (Basigin 2), Q6P6R2 (Dihydrolipoamide dehydrogenase),   P04797 (GAPDH), Q63081 (Protein disulfide isomerase), P29457 (47 kDa heat shock protein), Q9R1J8 (Leprecan), O88638 (Putative eps protein),   Q64375 (Synaptonemal complex)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:NDPK - Interactions involving proteins containing InterPro domain IPR001564, Nucleoside diphosphate kinase, core.	taxid:10116(rat-l6)|taxid:10116(Rattus norvegicus)	-	2006/02/15	2021/11/30	rogid:PbFY2lfrty8yw40Jq7ShR7xfuV410116	rogid:Ew2uUYIXrZ8nnP52xMnGB6KOCqc10116	intact-crc:44F3A2176D02515F|rigid:9RVm0UBcqQF4k06RGKO89Bg16Q8	false	myc tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P19357	uniprotkb:P11507	intact:EBI-915426|uniprotkb:P97900|ensembl:ENSRNOP00000023256	intact:EBI-916319|uniprotkb:P11508|ensembl:ENSRNOP00000024347	psi-mi:glut4_rat(display_long)|uniprotkb:Glucose transporter type 4, insulin-responsive(gene name synonym)|uniprotkb:Slc2a4(gene name)|psi-mi:Slc2a4(display_short)|uniprotkb:Glut4(gene name synonym)	psi-mi:at2a2_rat(display_long)|uniprotkb:Calcium pump 2(gene name synonym)|uniprotkb:Calcium-transporting ATPase sarcoplasmic reticulum type, slow twitch skeletal muscle isoform(gene name synonym)|uniprotkb:"Endoplasmic reticulum class 1/2 Ca(2+) ATPase"(gene name synonym)|uniprotkb:Atp2a2(gene name)|psi-mi:Atp2a2(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Foster et al. (2006)	pubmed:16396496|mint:MINT-5218203	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-921030	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2711|refseq:NP_036883.1|refseq:XP_006246658.1|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007611"(learning or memory)|go:"GO:0007614"(short-term memory)|go:"GO:0007616"(long-term memory)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010021"(amylopectin biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031550"(positive regulation of brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044381"(glucose import in response to insulin stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046323"(glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0098694"(regulation of synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0098793"(presynapse)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002441("Glucose transporter, type 4 (GLUT4)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-189200|ensembl:ENSRNOG00000017226(gene)|ensembl:ENSRNOT00000023256(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)	ensembl:ENSRNOG00000001285(gene)|ensembl:ENSRNOT00000024347(transcript)|go:"GO:0000045"(autophagosome assembly)|go:"GO:0002026"(regulation of the force of heart contraction)|go:"GO:0003009"(skeletal muscle contraction)|go:"GO:0005388"(P-type calcium transporter activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0006937"(regulation of muscle contraction)|go:"GO:0006984"(ER-nucleus signaling pathway)|go:"GO:0006996"(organelle organization)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008553"(P-type proton-exporting transporter activity)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0012506"(vesicle membrane)|go:"GO:0014883"(transition between fast and slow fiber)|go:"GO:0120025"(plasma membrane bounded cell projection)|go:"GO:0140056"(organelle localization by membrane tethering)|go:"GO:1900121"(negative regulation of receptor binding)|go:"GO:1903233"(regulation of calcium ion-dependent exocytosis of neurotransmitter)|go:"GO:1903515"(calcium ion transport from cytosol to endoplasmic reticulum)|go:"GO:1990036"(calcium ion import into sarcoplasmic reticulum)|go:"GO:1990456"(mitochondrion-endoplasmic reticulum membrane tethering)|interpro:IPR001757(ATPase, P-type, K/Mg/Cd/Cu/Zn/Na/Ca/Na/H-transporter)|interpro:IPR004014(ATPase, P-type cation-transporter, N-terminal)|interpro:IPR005782(Calcium ATPase)|interpro:IPR006068(ATPase, P-type cation-transporter, C-terminal)|interpro:IPR008250(E1-E2 ATPase-associated region)|interpro:IPR018303|interpro:IPR023214|interpro:IPR023298|interpro:IPR023299|interpro:IPR036412|interpro:IPR044492|mint:P11507|reactome:R-RNO-418359|reactome:R-RNO-5578775|reactome:R-RNO-936837|go:"GO:0014898"(cardiac muscle hypertrophy in response to stress)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016240"(autophagosome membrane docking)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0019899"(enzyme binding)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031775"(lutropin-choriogonadotropic hormone receptor binding)|go:"GO:0032469"(endoplasmic reticulum calcium ion homeostasis)|go:"GO:0032470"(positive regulation of endoplasmic reticulum calcium ion concentration)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033017"(sarcoplasmic reticulum membrane)|go:"GO:0033292"(T-tubule organization)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0034605"(cellular response to heat)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0043434"(response to peptide hormone)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044548"(S100 protein binding)|go:"GO:0045822"(negative regulation of heart contraction)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0055119"(relaxation of cardiac muscle)|go:"GO:0061831"(apical ectoplasmic specialization)|go:"GO:0070296"(sarcoplasmic reticulum calcium ion transport)|go:"GO:0070588"(calcium ion transmembrane transport)|go:"GO:0086036"(regulation of cardiac muscle cell membrane potential)|go:"GO:0086039"(P-type calcium transporter activity involved in regulation of cardiac muscle cell membrane potential)|go:"GO:0097470"(ribbon synapse)|go:"GO:0098909"(regulation of cardiac muscle cell action potential involved in regulation of contraction)|rgd:2174|refseq:NP_001103609.1|refseq:NP_001104293.1	-	-	-	caution:"The participant EBI-349571(P68370) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919386(Q7TP47) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920972(Q5XIP9) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-916419(P11980) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919578(Q8R491) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920554(Q5U3Z7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920647(Q5U2X8) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920585(Q7TP24) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-779677(P05426) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-915744(P02454) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|agonist:Insulin was shown to increase or decrease GLUT4 protein interactions in specific cases.|comment:"Insulin decreased GLUT4 interactions with the following proteins: Q9ER30 (Sarcosin), P09527 (Rab-7), O88960 (N-ethylmaleimide sensitive), P09456 (PKA I regulatory subunit), P27881 (Hexokinase type II), P07872 (Acyl-coenzyme A oxidase), Q6DGF1 (Isocitrate dehydrogenase), Q9EQX9 (Ubiquitin-conjugating), Q63446 (Polyubiquitin), P24268 (Cathepsin D), Q91XW0 (Heat shock protein 86), Q5FVH0 (unknown), P58405 (Striatin 3), Q62667 (Major vault protein), Q66H50 (unknown), Q09167 (splicing factor), Q9JHU5 (Arfaptin 1)."|comment:"Insulin increased GLUT4 interaction with the following proteins:Q9Z1P2 (R-actinin-1), P45592 (Cofilin), Q9QXQ0 (R-actinin-4), P26473 (ADP-ribosylation factor), P26437 (ADP-ribosylation factor),   Q7TNP1 (Basigin 2), Q6P6R2 (Dihydrolipoamide dehydrogenase),   P04797 (GAPDH), Q63081 (Protein disulfide isomerase), P29457 (47 kDa heat shock protein), Q9R1J8 (Leprecan), O88638 (Putative eps protein),   Q64375 (Synaptonemal complex)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:NDPK - Interactions involving proteins containing InterPro domain IPR001564, Nucleoside diphosphate kinase, core.	taxid:10116(rat-l6)|taxid:10116(Rattus norvegicus)	-	2006/02/15	2021/11/30	rogid:PbFY2lfrty8yw40Jq7ShR7xfuV410116	rogid:Et/ot4KEtlnq8iuoVL0CySJICIo10116	intact-crc:44F3A2176D02515F|rigid:9RVm0UBcqQF4k06RGKO89Bg16Q8	false	myc tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P19357	uniprotkb:P11442	intact:EBI-915426|uniprotkb:P97900|ensembl:ENSRNOP00000023256	intact:EBI-397997	psi-mi:glut4_rat(display_long)|uniprotkb:Glucose transporter type 4, insulin-responsive(gene name synonym)|uniprotkb:Slc2a4(gene name)|psi-mi:Slc2a4(display_short)|uniprotkb:Glut4(gene name synonym)	psi-mi:clh1_rat(display_long)|uniprotkb:Cltc(gene name)|psi-mi:Cltc(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Foster et al. (2006)	pubmed:16396496|mint:MINT-5218203	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-921030	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2711|refseq:NP_036883.1|refseq:XP_006246658.1|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007611"(learning or memory)|go:"GO:0007614"(short-term memory)|go:"GO:0007616"(long-term memory)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010021"(amylopectin biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031550"(positive regulation of brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044381"(glucose import in response to insulin stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046323"(glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0098694"(regulation of synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0098793"(presynapse)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002441("Glucose transporter, type 4 (GLUT4)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-189200|ensembl:ENSRNOG00000017226(gene)|ensembl:ENSRNOT00000023256(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)	rgd:2364|refseq:NP_062172.1|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0006914"(autophagy)|go:"GO:0007030"(Golgi organization)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0016020"(membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030117"(membrane coat)|go:"GO:0030118"(clathrin coat)|go:"GO:0030130"(clathrin coat of trans-Golgi network vesicle)|go:"GO:0030132"(clathrin coat of coated pit)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030506"(ankyrin binding)|go:"GO:0030669"(clathrin-coated endocytic vesicle membrane)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031623"(receptor internalization)|go:"GO:0032051"(clathrin light chain binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033572"(transferrin transport)|go:"GO:0042147"(retrograde transport, endosome to Golgi)|go:"GO:0042277"(peptide binding)|go:"GO:0042383"(sarcolemma)|go:"GO:0042470"(melanosome)|go:"GO:0043195"(terminal bouton)|go:"GO:0045334"(clathrin-coated endocytic vesicle)|interpro:IPR015348(Clathrin, heavy chain, linker, core motif)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR016025(Clathrin, heavy chain, linker and propeller)|go:"GO:0048268"(clathrin coat assembly)|go:"GO:0048488"(synaptic vesicle endocytosis)|go:"GO:0050750"(low-density lipoprotein particle receptor binding)|go:"GO:0060236"(regulation of mitotic spindle organization)|go:"GO:0071439"(clathrin complex)|go:"GO:0072583"(clathrin-dependent endocytosis)|go:"GO:0097718"(disordered domain specific binding)|go:"GO:0098684"(photoreceptor ribbon synapse)|go:"GO:0098835"(presynaptic endocytic zone membrane)|go:"GO:0098850"(extrinsic component of synaptic vesicle membrane)|go:"GO:0150093"(amyloid-beta clearance by transcytosis)|go:"GO:1900126"(negative regulation of hyaluronan biosynthetic process)|go:"GO:1903077"(negative regulation of protein localization to plasma membrane)|go:"GO:1990381"(ubiquitin-specific protease binding)|go:"GO:1990498"(mitotic spindle microtubule)|interpro:IPR000547(Clathrin, heavy chain/VPS, 7-fold repeat)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR016341(Clathrin, heavy chain)|interpro:IPR022365|rcsb pdb:1BPO|rcsb pdb:1C9I|rcsb pdb:1C9L|reactome:R-RNO-177504|reactome:R-RNO-190873|reactome:R-RNO-196025|reactome:R-RNO-2132295|reactome:R-RNO-432720|reactome:R-RNO-432722|reactome:R-RNO-437239|reactome:R-RNO-5099900|reactome:R-RNO-5140745|reactome:R-RNO-8856825|reactome:R-RNO-8856828|reactome:R-RNO-8866427|reactome:R-RNO-8964038|reactome:R-RNO-9013420|reactome:R-RNO-9013424|mint:P11442|dip:DIP-36966N	-	-	-	caution:"The participant EBI-349571(P68370) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919386(Q7TP47) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920972(Q5XIP9) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-916419(P11980) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919578(Q8R491) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920554(Q5U3Z7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920647(Q5U2X8) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920585(Q7TP24) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-779677(P05426) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-915744(P02454) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|agonist:Insulin was shown to increase or decrease GLUT4 protein interactions in specific cases.|comment:"Insulin decreased GLUT4 interactions with the following proteins: Q9ER30 (Sarcosin), P09527 (Rab-7), O88960 (N-ethylmaleimide sensitive), P09456 (PKA I regulatory subunit), P27881 (Hexokinase type II), P07872 (Acyl-coenzyme A oxidase), Q6DGF1 (Isocitrate dehydrogenase), Q9EQX9 (Ubiquitin-conjugating), Q63446 (Polyubiquitin), P24268 (Cathepsin D), Q91XW0 (Heat shock protein 86), Q5FVH0 (unknown), P58405 (Striatin 3), Q62667 (Major vault protein), Q66H50 (unknown), Q09167 (splicing factor), Q9JHU5 (Arfaptin 1)."|comment:"Insulin increased GLUT4 interaction with the following proteins:Q9Z1P2 (R-actinin-1), P45592 (Cofilin), Q9QXQ0 (R-actinin-4), P26473 (ADP-ribosylation factor), P26437 (ADP-ribosylation factor),   Q7TNP1 (Basigin 2), Q6P6R2 (Dihydrolipoamide dehydrogenase),   P04797 (GAPDH), Q63081 (Protein disulfide isomerase), P29457 (47 kDa heat shock protein), Q9R1J8 (Leprecan), O88638 (Putative eps protein),   Q64375 (Synaptonemal complex)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:NDPK - Interactions involving proteins containing InterPro domain IPR001564, Nucleoside diphosphate kinase, core.	taxid:10116(rat-l6)|taxid:10116(Rattus norvegicus)	-	2006/02/15	2021/11/30	rogid:PbFY2lfrty8yw40Jq7ShR7xfuV410116	rogid:IRKdzbAIpw7D7qHqyxStNyfI38g10116	intact-crc:44F3A2176D02515F|rigid:9RVm0UBcqQF4k06RGKO89Bg16Q8	false	myc tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P19357	uniprotkb:P11240	intact:EBI-915426|uniprotkb:P97900|ensembl:ENSRNOP00000023256	intact:EBI-916313|ensembl:ENSRNOP00000025525	psi-mi:glut4_rat(display_long)|uniprotkb:Glucose transporter type 4, insulin-responsive(gene name synonym)|uniprotkb:Slc2a4(gene name)|psi-mi:Slc2a4(display_short)|uniprotkb:Glut4(gene name synonym)	psi-mi:cox5a_rat(display_long)|uniprotkb:Cox5a(gene name)|psi-mi:Cox5a(display_short)|uniprotkb:Cytochrome c oxidase polypeptide Va(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Foster et al. (2006)	pubmed:16396496|mint:MINT-5218203	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-921030	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2711|refseq:NP_036883.1|refseq:XP_006246658.1|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007611"(learning or memory)|go:"GO:0007614"(short-term memory)|go:"GO:0007616"(long-term memory)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010021"(amylopectin biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031550"(positive regulation of brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044381"(glucose import in response to insulin stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046323"(glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0098694"(regulation of synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0098793"(presynapse)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002441("Glucose transporter, type 4 (GLUT4)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-189200|ensembl:ENSRNOG00000017226(gene)|ensembl:ENSRNOT00000023256(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)	ensembl:ENSRNOG00000018816(gene)|ensembl:ENSRNOT00000025525(transcript)|go:"GO:0004129"(cytochrome-c oxidase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005751"(mitochondrial respiratory chain complex IV)|go:"GO:0006123"(mitochondrial electron transport, cytochrome c to oxygen)|go:"GO:0046872"(metal ion binding)|interpro:IPR003204(Cytochrome c oxidase, subunit Va)|interpro:IPR036545|mint:P11240|reactome:R-RNO-5628897|reactome:R-RNO-611105|reactome:R-RNO-9707564|rgd:620607|refseq:NP_665726.1	-	-	-	caution:"The participant EBI-349571(P68370) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919386(Q7TP47) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920972(Q5XIP9) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-916419(P11980) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919578(Q8R491) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920554(Q5U3Z7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920647(Q5U2X8) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920585(Q7TP24) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-779677(P05426) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-915744(P02454) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|agonist:Insulin was shown to increase or decrease GLUT4 protein interactions in specific cases.|comment:"Insulin decreased GLUT4 interactions with the following proteins: Q9ER30 (Sarcosin), P09527 (Rab-7), O88960 (N-ethylmaleimide sensitive), P09456 (PKA I regulatory subunit), P27881 (Hexokinase type II), P07872 (Acyl-coenzyme A oxidase), Q6DGF1 (Isocitrate dehydrogenase), Q9EQX9 (Ubiquitin-conjugating), Q63446 (Polyubiquitin), P24268 (Cathepsin D), Q91XW0 (Heat shock protein 86), Q5FVH0 (unknown), P58405 (Striatin 3), Q62667 (Major vault protein), Q66H50 (unknown), Q09167 (splicing factor), Q9JHU5 (Arfaptin 1)."|comment:"Insulin increased GLUT4 interaction with the following proteins:Q9Z1P2 (R-actinin-1), P45592 (Cofilin), Q9QXQ0 (R-actinin-4), P26473 (ADP-ribosylation factor), P26437 (ADP-ribosylation factor),   Q7TNP1 (Basigin 2), Q6P6R2 (Dihydrolipoamide dehydrogenase),   P04797 (GAPDH), Q63081 (Protein disulfide isomerase), P29457 (47 kDa heat shock protein), Q9R1J8 (Leprecan), O88638 (Putative eps protein),   Q64375 (Synaptonemal complex)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:NDPK - Interactions involving proteins containing InterPro domain IPR001564, Nucleoside diphosphate kinase, core.	taxid:10116(rat-l6)|taxid:10116(Rattus norvegicus)	-	2006/02/15	2021/11/30	rogid:PbFY2lfrty8yw40Jq7ShR7xfuV410116	rogid:Q35b6ItDmdEEx57GuPXOA3rR8qM10116	intact-crc:44F3A2176D02515F|rigid:9RVm0UBcqQF4k06RGKO89Bg16Q8	false	myc tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P19357	uniprotkb:P11232	intact:EBI-915426|uniprotkb:P97900|ensembl:ENSRNOP00000023256	intact:EBI-916302	psi-mi:glut4_rat(display_long)|uniprotkb:Glucose transporter type 4, insulin-responsive(gene name synonym)|uniprotkb:Slc2a4(gene name)|psi-mi:Slc2a4(display_short)|uniprotkb:Glut4(gene name synonym)	psi-mi:thio_rat(display_long)|uniprotkb:Txn(gene name)|psi-mi:Txn(display_short)|uniprotkb:Txn1(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Foster et al. (2006)	pubmed:16396496|mint:MINT-5218203	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-921030	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2711|refseq:NP_036883.1|refseq:XP_006246658.1|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007611"(learning or memory)|go:"GO:0007614"(short-term memory)|go:"GO:0007616"(long-term memory)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010021"(amylopectin biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031550"(positive regulation of brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044381"(glucose import in response to insulin stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046323"(glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0098694"(regulation of synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0098793"(presynapse)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002441("Glucose transporter, type 4 (GLUT4)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-189200|ensembl:ENSRNOG00000017226(gene)|ensembl:ENSRNOT00000023256(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)	go:"GO:0005634"(nucleus)|go:"GO:0045454"(cell redox homeostasis)|go:"GO:0046826"(negative regulation of protein export from nucleus)|go:"GO:0047134"("protein-disulfide reductase (NAD(P)) activity")|go:"GO:0048678"(response to axon injury)|go:"GO:0071236"(cellular response to antibiotic)|go:"GO:0071333"(cellular response to glucose stimulus)|go:"GO:0071455"(cellular response to hyperoxia)|go:"GO:0071548"(response to dexamethasone)|go:"GO:0071731"(response to nitric oxide)|go:"GO:0097068"(response to thyroxine)|go:"GO:1903206"(negative regulation of hydrogen peroxide-induced cell death)|go:"GO:2000170"(positive regulation of peptidyl-cysteine S-nitrosylation)|reactome:R-RNO-2559580|reactome:R-RNO-3299685|reactome:R-RNO-499943|reactome:R-RNO-5628897|reactome:R-RNO-5676934|reactome:R-RNO-844456|go:"GO:0005576"(extracellular region)|go:"GO:0014823"(response to activity)|go:"GO:0015035"(protein-disulfide reductase activity)|go:"GO:0019899"(enzyme binding)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0035690"|go:"GO:0042493"|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043388"(positive regulation of DNA binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006662"(glycerol ether metabolic process)|go:"GO:0009314"(response to radiation)|go:"GO:0010269"(response to selenium ion)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0004791"(thioredoxin-disulfide reductase activity)|rgd:621157|refseq:NP_446252.1|interpro:IPR005746(Thioredoxin)|interpro:IPR017937|interpro:IPR013766(Thioredoxin domain)|mint:P11232|interpro:IPR036249	-	-	-	caution:"The participant EBI-349571(P68370) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919386(Q7TP47) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920972(Q5XIP9) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-916419(P11980) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919578(Q8R491) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920554(Q5U3Z7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920647(Q5U2X8) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920585(Q7TP24) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-779677(P05426) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-915744(P02454) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|agonist:Insulin was shown to increase or decrease GLUT4 protein interactions in specific cases.|comment:"Insulin decreased GLUT4 interactions with the following proteins: Q9ER30 (Sarcosin), P09527 (Rab-7), O88960 (N-ethylmaleimide sensitive), P09456 (PKA I regulatory subunit), P27881 (Hexokinase type II), P07872 (Acyl-coenzyme A oxidase), Q6DGF1 (Isocitrate dehydrogenase), Q9EQX9 (Ubiquitin-conjugating), Q63446 (Polyubiquitin), P24268 (Cathepsin D), Q91XW0 (Heat shock protein 86), Q5FVH0 (unknown), P58405 (Striatin 3), Q62667 (Major vault protein), Q66H50 (unknown), Q09167 (splicing factor), Q9JHU5 (Arfaptin 1)."|comment:"Insulin increased GLUT4 interaction with the following proteins:Q9Z1P2 (R-actinin-1), P45592 (Cofilin), Q9QXQ0 (R-actinin-4), P26473 (ADP-ribosylation factor), P26437 (ADP-ribosylation factor),   Q7TNP1 (Basigin 2), Q6P6R2 (Dihydrolipoamide dehydrogenase),   P04797 (GAPDH), Q63081 (Protein disulfide isomerase), P29457 (47 kDa heat shock protein), Q9R1J8 (Leprecan), O88638 (Putative eps protein),   Q64375 (Synaptonemal complex)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:NDPK - Interactions involving proteins containing InterPro domain IPR001564, Nucleoside diphosphate kinase, core.	taxid:10116(rat-l6)|taxid:10116(Rattus norvegicus)	-	2006/02/15	2021/11/30	rogid:PbFY2lfrty8yw40Jq7ShR7xfuV410116	rogid:YEZTjJoaEiTgQe/tyxzrpU+HCVk10116	intact-crc:44F3A2176D02515F|rigid:9RVm0UBcqQF4k06RGKO89Bg16Q8	false	myc tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P19357	uniprotkb:P62845	intact:EBI-915426|uniprotkb:P97900|ensembl:ENSRNOP00000023256	intact:EBI-372679|uniprotkb:P11174|ensembl:ENSRNOP00000035156	psi-mi:glut4_rat(display_long)|uniprotkb:Glucose transporter type 4, insulin-responsive(gene name synonym)|uniprotkb:Slc2a4(gene name)|psi-mi:Slc2a4(display_short)|uniprotkb:Glut4(gene name synonym)	psi-mi:rs15_rat(display_long)|uniprotkb:Rps15(gene name)|psi-mi:Rps15(display_short)|uniprotkb:RIG protein(gene name synonym)|uniprotkb:Rig(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Foster et al. (2006)	pubmed:16396496|mint:MINT-5218203	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-921030	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2711|refseq:NP_036883.1|refseq:XP_006246658.1|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007611"(learning or memory)|go:"GO:0007614"(short-term memory)|go:"GO:0007616"(long-term memory)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010021"(amylopectin biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031550"(positive regulation of brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044381"(glucose import in response to insulin stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046323"(glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0098694"(regulation of synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0098793"(presynapse)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002441("Glucose transporter, type 4 (GLUT4)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-189200|ensembl:ENSRNOG00000017226(gene)|ensembl:ENSRNOT00000023256(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)	rgd:62026|refseq:NP_058847.1|ensembl:ENSRNOG00000024603(gene)|ensembl:ENSRNOT00000029791(transcript)|go:"GO:0000028"(ribosomal small subunit assembly)|go:"GO:0000056"(ribosomal small subunit export from nucleus)|go:"GO:0003723"(RNA binding)|go:"GO:0003735"(structural constituent of ribosome)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006364"(rRNA processing)|go:"GO:0006412"(translation)|go:"GO:0022626"(cytosolic ribosome)|go:"GO:0022627"(cytosolic small ribosomal subunit)|go:"GO:0042274"(ribosomal small subunit biogenesis)|go:"GO:0045202"(synapse)|go:"GO:0097371"(MDM2/MDM4 family protein binding)|go:"GO:0097421"(liver regeneration)|go:"GO:1901798"(positive regulation of signal transduction by p53 class mediator)|go:"GO:1990948"(ubiquitin ligase inhibitor activity)|interpro:IPR002222(Ribosomal protein S19/S15)|interpro:IPR005713(Ribosomal protein S15, eukaryotic/archaeal)|interpro:IPR020934|interpro:IPR023575|reactome:R-RNO-156827|reactome:R-RNO-1799339|reactome:R-RNO-6791226|reactome:R-RNO-72649|reactome:R-RNO-72689|reactome:R-RNO-72695|reactome:R-RNO-72702|reactome:R-RNO-72706|reactome:R-RNO-975956|reactome:R-RNO-975957	-	-	-	caution:"The participant EBI-349571(P68370) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919386(Q7TP47) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920972(Q5XIP9) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-916419(P11980) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919578(Q8R491) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920554(Q5U3Z7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920647(Q5U2X8) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920585(Q7TP24) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-779677(P05426) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-915744(P02454) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|agonist:Insulin was shown to increase or decrease GLUT4 protein interactions in specific cases.|comment:"Insulin decreased GLUT4 interactions with the following proteins: Q9ER30 (Sarcosin), P09527 (Rab-7), O88960 (N-ethylmaleimide sensitive), P09456 (PKA I regulatory subunit), P27881 (Hexokinase type II), P07872 (Acyl-coenzyme A oxidase), Q6DGF1 (Isocitrate dehydrogenase), Q9EQX9 (Ubiquitin-conjugating), Q63446 (Polyubiquitin), P24268 (Cathepsin D), Q91XW0 (Heat shock protein 86), Q5FVH0 (unknown), P58405 (Striatin 3), Q62667 (Major vault protein), Q66H50 (unknown), Q09167 (splicing factor), Q9JHU5 (Arfaptin 1)."|comment:"Insulin increased GLUT4 interaction with the following proteins:Q9Z1P2 (R-actinin-1), P45592 (Cofilin), Q9QXQ0 (R-actinin-4), P26473 (ADP-ribosylation factor), P26437 (ADP-ribosylation factor),   Q7TNP1 (Basigin 2), Q6P6R2 (Dihydrolipoamide dehydrogenase),   P04797 (GAPDH), Q63081 (Protein disulfide isomerase), P29457 (47 kDa heat shock protein), Q9R1J8 (Leprecan), O88638 (Putative eps protein),   Q64375 (Synaptonemal complex)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:NDPK - Interactions involving proteins containing InterPro domain IPR001564, Nucleoside diphosphate kinase, core.	taxid:10116(rat-l6)|taxid:10116(Rattus norvegicus)	-	2006/02/15	2021/11/30	rogid:PbFY2lfrty8yw40Jq7ShR7xfuV410116	rogid:lJJOew1txuTwFlhKu4Z+AkPS5H010116	intact-crc:44F3A2176D02515F|rigid:9RVm0UBcqQF4k06RGKO89Bg16Q8	false	myc tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P19357	uniprotkb:P62963	intact:EBI-915426|uniprotkb:P97900|ensembl:ENSRNOP00000023256	intact:EBI-916295|uniprotkb:P10924|ensembl:ENSRNOP00000005370	psi-mi:glut4_rat(display_long)|uniprotkb:Glucose transporter type 4, insulin-responsive(gene name synonym)|uniprotkb:Slc2a4(gene name)|psi-mi:Slc2a4(display_short)|uniprotkb:Glut4(gene name synonym)	psi-mi:prof1_rat(display_long)|uniprotkb:Pfn1(gene name)|psi-mi:Pfn1(display_short)|uniprotkb:Profilin I(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Foster et al. (2006)	pubmed:16396496|mint:MINT-5218203	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-921030	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2711|refseq:NP_036883.1|refseq:XP_006246658.1|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007611"(learning or memory)|go:"GO:0007614"(short-term memory)|go:"GO:0007616"(long-term memory)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010021"(amylopectin biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031550"(positive regulation of brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044381"(glucose import in response to insulin stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046323"(glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0098694"(regulation of synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0098793"(presynapse)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002441("Glucose transporter, type 4 (GLUT4)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-189200|ensembl:ENSRNOG00000017226(gene)|ensembl:ENSRNOT00000023256(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)	refseq:NP_071956.2|go:"GO:0032781"(positive regulation of ATP-dependent activity)|go:"GO:0043005"(neuron projection)|go:"GO:0045202"(synapse)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0050434"(positive regulation of viral transcription)|go:"GO:0050821"(protein stabilization)|go:"GO:0051054"(positive regulation of DNA metabolic process)|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0051497"(negative regulation of stress fiber assembly)|go:"GO:0060074"(synapse maturation)|go:"GO:0070064"(proline-rich region binding)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098688"(parallel fiber to Purkinje cell synapse)|go:"GO:0098793"(presynapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098885"(modification of postsynaptic actin cytoskeleton)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1900029"(positive regulation of ruffle assembly)|interpro:IPR005454(Profilin, Mammalian)|interpro:IPR005455(Profilin, plant)|interpro:IPR027310|interpro:IPR029892|interpro:IPR036140|ensembl:ENSRNOG00000003975(gene)|ensembl:ENSRNOT00000005370(transcript)|go:"GO:0000774"(adenyl-nucleotide exchange factor activity)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0001843"(neural tube closure)|go:"GO:0003779"(actin binding)|go:"GO:0003785"(actin monomer binding)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005546"(phosphatidylinositol-4,5-bisphosphate binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005938"(cell cortex)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008154"(actin polymerization or depolymerization)|go:"GO:0010033"(response to organic substance)|go:"GO:0010634"(positive regulation of epithelial cell migration)|go:"GO:0030833"(regulation of actin filament polymerization)|go:"GO:0030837"(negative regulation of actin filament polymerization)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0031267"(small GTPase binding)|go:"GO:0032232"(negative regulation of actin filament bundle assembly)|go:"GO:0032233"(positive regulation of actin filament bundle assembly)|mint:P62963|reactome:R-RNO-4086400|reactome:R-RNO-5663220|rgd:621825	-	-	-	caution:"The participant EBI-349571(P68370) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919386(Q7TP47) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920972(Q5XIP9) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-916419(P11980) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919578(Q8R491) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920554(Q5U3Z7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920647(Q5U2X8) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920585(Q7TP24) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-779677(P05426) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-915744(P02454) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|agonist:Insulin was shown to increase or decrease GLUT4 protein interactions in specific cases.|comment:"Insulin decreased GLUT4 interactions with the following proteins: Q9ER30 (Sarcosin), P09527 (Rab-7), O88960 (N-ethylmaleimide sensitive), P09456 (PKA I regulatory subunit), P27881 (Hexokinase type II), P07872 (Acyl-coenzyme A oxidase), Q6DGF1 (Isocitrate dehydrogenase), Q9EQX9 (Ubiquitin-conjugating), Q63446 (Polyubiquitin), P24268 (Cathepsin D), Q91XW0 (Heat shock protein 86), Q5FVH0 (unknown), P58405 (Striatin 3), Q62667 (Major vault protein), Q66H50 (unknown), Q09167 (splicing factor), Q9JHU5 (Arfaptin 1)."|comment:"Insulin increased GLUT4 interaction with the following proteins:Q9Z1P2 (R-actinin-1), P45592 (Cofilin), Q9QXQ0 (R-actinin-4), P26473 (ADP-ribosylation factor), P26437 (ADP-ribosylation factor),   Q7TNP1 (Basigin 2), Q6P6R2 (Dihydrolipoamide dehydrogenase),   P04797 (GAPDH), Q63081 (Protein disulfide isomerase), P29457 (47 kDa heat shock protein), Q9R1J8 (Leprecan), O88638 (Putative eps protein),   Q64375 (Synaptonemal complex)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:NDPK - Interactions involving proteins containing InterPro domain IPR001564, Nucleoside diphosphate kinase, core.	taxid:10116(rat-l6)|taxid:10116(Rattus norvegicus)	-	2006/02/15	2021/11/30	rogid:PbFY2lfrty8yw40Jq7ShR7xfuV410116	rogid:nzOTw5XdywGrh+fA9AInGIexyGk10116	intact-crc:44F3A2176D02515F|rigid:9RVm0UBcqQF4k06RGKO89Bg16Q8	false	myc tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P19357	uniprotkb:P10888	intact:EBI-915426|uniprotkb:P97900|ensembl:ENSRNOP00000023256	intact:EBI-916287|ensembl:ENSRNOP00000024033	psi-mi:glut4_rat(display_long)|uniprotkb:Glucose transporter type 4, insulin-responsive(gene name synonym)|uniprotkb:Slc2a4(gene name)|psi-mi:Slc2a4(display_short)|uniprotkb:Glut4(gene name synonym)	psi-mi:cox41_rat(display_long)|uniprotkb:Cox4i1(gene name)|psi-mi:Cox4i1(display_short)|uniprotkb:Cox4(gene name synonym)|uniprotkb:Cox4a(gene name synonym)|uniprotkb:Cytochrome c oxidase subunit IV isoform 1(gene name synonym)|uniprotkb:Cytochrome c oxidase polypeptide IV(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Foster et al. (2006)	pubmed:16396496|mint:MINT-5218203	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-921030	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2711|refseq:NP_036883.1|refseq:XP_006246658.1|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007611"(learning or memory)|go:"GO:0007614"(short-term memory)|go:"GO:0007616"(long-term memory)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010021"(amylopectin biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031550"(positive regulation of brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044381"(glucose import in response to insulin stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046323"(glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0098694"(regulation of synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0098793"(presynapse)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002441("Glucose transporter, type 4 (GLUT4)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-189200|ensembl:ENSRNOG00000017226(gene)|ensembl:ENSRNOT00000023256(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)	rgd:68374|refseq:NP_058898.1|ensembl:ENSRNOG00000017817(gene)|ensembl:ENSRNOT00000024033(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005751"(mitochondrial respiratory chain complex IV)|go:"GO:0005829"(cytosol)|go:"GO:0006123"(mitochondrial electron transport, cytochrome c to oxygen)|go:"GO:0007584"(response to nutrient)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016491"(oxidoreductase activity)|go:"GO:0031966"(mitochondrial membrane)|interpro:IPR004203(Cytochrome c oxidase subunit IV)|interpro:IPR013288(Cytochrome c oxidase subunit 4)|interpro:IPR036639|mint:P10888|reactome:R-RNO-5628897|reactome:R-RNO-611105|reactome:R-RNO-9707564	-	-	-	caution:"The participant EBI-349571(P68370) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919386(Q7TP47) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920972(Q5XIP9) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-916419(P11980) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919578(Q8R491) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920554(Q5U3Z7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920647(Q5U2X8) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920585(Q7TP24) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-779677(P05426) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-915744(P02454) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|agonist:Insulin was shown to increase or decrease GLUT4 protein interactions in specific cases.|comment:"Insulin decreased GLUT4 interactions with the following proteins: Q9ER30 (Sarcosin), P09527 (Rab-7), O88960 (N-ethylmaleimide sensitive), P09456 (PKA I regulatory subunit), P27881 (Hexokinase type II), P07872 (Acyl-coenzyme A oxidase), Q6DGF1 (Isocitrate dehydrogenase), Q9EQX9 (Ubiquitin-conjugating), Q63446 (Polyubiquitin), P24268 (Cathepsin D), Q91XW0 (Heat shock protein 86), Q5FVH0 (unknown), P58405 (Striatin 3), Q62667 (Major vault protein), Q66H50 (unknown), Q09167 (splicing factor), Q9JHU5 (Arfaptin 1)."|comment:"Insulin increased GLUT4 interaction with the following proteins:Q9Z1P2 (R-actinin-1), P45592 (Cofilin), Q9QXQ0 (R-actinin-4), P26473 (ADP-ribosylation factor), P26437 (ADP-ribosylation factor),   Q7TNP1 (Basigin 2), Q6P6R2 (Dihydrolipoamide dehydrogenase),   P04797 (GAPDH), Q63081 (Protein disulfide isomerase), P29457 (47 kDa heat shock protein), Q9R1J8 (Leprecan), O88638 (Putative eps protein),   Q64375 (Synaptonemal complex)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:NDPK - Interactions involving proteins containing InterPro domain IPR001564, Nucleoside diphosphate kinase, core.	taxid:10116(rat-l6)|taxid:10116(Rattus norvegicus)	-	2006/02/15	2021/11/30	rogid:PbFY2lfrty8yw40Jq7ShR7xfuV410116	rogid:tNIBFX8yX4FTJHKAMI9P5dGA5hE10116	intact-crc:44F3A2176D02515F|rigid:9RVm0UBcqQF4k06RGKO89Bg16Q8	false	myc tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P19357	uniprotkb:P10860	intact:EBI-915426|uniprotkb:P97900|ensembl:ENSRNOP00000023256	intact:EBI-349589|uniprotkb:Q66HI8|ensembl:ENSRNOP00000075032|uniprotkb:Q6LC16	psi-mi:glut4_rat(display_long)|uniprotkb:Glucose transporter type 4, insulin-responsive(gene name synonym)|uniprotkb:Slc2a4(gene name)|psi-mi:Slc2a4(display_short)|uniprotkb:Glut4(gene name synonym)	psi-mi:dhe3_rat(display_long)|uniprotkb:Glud1(gene name)|psi-mi:Glud1(display_short)|uniprotkb:Glud(gene name synonym)|uniprotkb:Memory-related gene 2 protein(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Foster et al. (2006)	pubmed:16396496|mint:MINT-5218203	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-921030	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2711|refseq:NP_036883.1|refseq:XP_006246658.1|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007611"(learning or memory)|go:"GO:0007614"(short-term memory)|go:"GO:0007616"(long-term memory)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010021"(amylopectin biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031550"(positive regulation of brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044381"(glucose import in response to insulin stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046323"(glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0098694"(regulation of synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0098793"(presynapse)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002441("Glucose transporter, type 4 (GLUT4)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-189200|ensembl:ENSRNOG00000017226(gene)|ensembl:ENSRNOT00000023256(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)	rgd:2708|refseq:NP_036702.1|ensembl:ENSRNOG00000057367(gene)|ensembl:ENSRNOT00000083446(transcript)|go:"GO:0004352"("glutamate dehydrogenase (NAD+) activity")|go:"GO:0004353"("glutamate dehydrogenase [NAD(P)+] activity")|go:"GO:0004354"("glutamate dehydrogenase (NADP+) activity")|go:"GO:0005524"(ATP binding)|go:"GO:0005525"(GTP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0006537"(glutamate biosynthetic process)|go:"GO:0006538"(glutamate catabolic process)|go:"GO:0006541"(glutamine metabolic process)|go:"GO:0007616"(long-term memory)|go:"GO:0010044"(response to aluminum ion)|go:"GO:0019899"(enzyme binding)|go:"GO:0021549"(cerebellum development)|go:"GO:0032024"(positive regulation of insulin secretion)|go:"GO:0043531"(ADP binding)|go:"GO:0070403"(NAD+ binding)|go:"GO:0070728"(leucine binding)|go:"GO:0072350"(tricarboxylic acid metabolic process)|interpro:IPR006095(Glutamate/phenylalanine/leucine/valine dehydrogenase)|interpro:IPR006096(Glutamate/phenylalanine/leucine/valine dehydrogenase, C-terminal)|interpro:IPR006097(Glutamate/phenylalanine/leucine/valine dehydrogenase, dimerisation region)|interpro:IPR033524|interpro:IPR033922|interpro:IPR036291|reactome:R-RNO-2151201|reactome:R-RNO-8964539	-	-	-	caution:"The participant EBI-349571(P68370) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919386(Q7TP47) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920972(Q5XIP9) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-916419(P11980) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919578(Q8R491) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920554(Q5U3Z7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920647(Q5U2X8) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920585(Q7TP24) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-779677(P05426) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-915744(P02454) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|agonist:Insulin was shown to increase or decrease GLUT4 protein interactions in specific cases.|comment:"Insulin decreased GLUT4 interactions with the following proteins: Q9ER30 (Sarcosin), P09527 (Rab-7), O88960 (N-ethylmaleimide sensitive), P09456 (PKA I regulatory subunit), P27881 (Hexokinase type II), P07872 (Acyl-coenzyme A oxidase), Q6DGF1 (Isocitrate dehydrogenase), Q9EQX9 (Ubiquitin-conjugating), Q63446 (Polyubiquitin), P24268 (Cathepsin D), Q91XW0 (Heat shock protein 86), Q5FVH0 (unknown), P58405 (Striatin 3), Q62667 (Major vault protein), Q66H50 (unknown), Q09167 (splicing factor), Q9JHU5 (Arfaptin 1)."|comment:"Insulin increased GLUT4 interaction with the following proteins:Q9Z1P2 (R-actinin-1), P45592 (Cofilin), Q9QXQ0 (R-actinin-4), P26473 (ADP-ribosylation factor), P26437 (ADP-ribosylation factor),   Q7TNP1 (Basigin 2), Q6P6R2 (Dihydrolipoamide dehydrogenase),   P04797 (GAPDH), Q63081 (Protein disulfide isomerase), P29457 (47 kDa heat shock protein), Q9R1J8 (Leprecan), O88638 (Putative eps protein),   Q64375 (Synaptonemal complex)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:NDPK - Interactions involving proteins containing InterPro domain IPR001564, Nucleoside diphosphate kinase, core.	taxid:10116(rat-l6)|taxid:10116(Rattus norvegicus)	-	2006/02/15	2021/11/30	rogid:PbFY2lfrty8yw40Jq7ShR7xfuV410116	rogid:zlcsF8gp3Su+wZh9hFLGE5G3Fvk10116	intact-crc:44F3A2176D02515F|rigid:9RVm0UBcqQF4k06RGKO89Bg16Q8	false	myc tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P19357	uniprotkb:P10760	intact:EBI-915426|uniprotkb:P97900|ensembl:ENSRNOP00000023256	intact:EBI-916280|ensembl:ENSRNOP00000024310	psi-mi:glut4_rat(display_long)|uniprotkb:Glucose transporter type 4, insulin-responsive(gene name synonym)|uniprotkb:Slc2a4(gene name)|psi-mi:Slc2a4(display_short)|uniprotkb:Glut4(gene name synonym)	psi-mi:sahh_rat(display_long)|uniprotkb:Ahcy(gene name)|psi-mi:Ahcy(display_short)|uniprotkb:S-adenosyl-L-homocysteine hydrolase(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Foster et al. (2006)	pubmed:16396496|mint:MINT-5218203	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-921030	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2711|refseq:NP_036883.1|refseq:XP_006246658.1|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007611"(learning or memory)|go:"GO:0007614"(short-term memory)|go:"GO:0007616"(long-term memory)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010021"(amylopectin biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031550"(positive regulation of brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044381"(glucose import in response to insulin stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046323"(glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0098694"(regulation of synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0098793"(presynapse)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002441("Glucose transporter, type 4 (GLUT4)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-189200|ensembl:ENSRNOG00000017226(gene)|ensembl:ENSRNOT00000023256(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)	ensembl:ENSRNOG00000017777(gene)|go:"GO:0005829"(cytosol)|go:"GO:0006730"(one-carbon metabolic process)|go:"GO:0007584"(response to nutrient)|go:"GO:0019510"(S-adenosylhomocysteine catabolic process)|go:"GO:0030554"(adenyl nucleotide binding)|ensembl:ENSRNOT00000024310(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002439"(chronic inflammatory response to antigenic stimulus)|go:"GO:0004013"(adenosylhomocysteinase activity)|go:"GO:0005507"(copper ion binding)|go:"GO:0005634"(nucleus)|go:"GO:0033353"(S-adenosylmethionine cycle)|go:"GO:0042470"(melanosome)|go:"GO:0042745"(circadian sleep/wake cycle)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043621"(protein self-association)|go:"GO:0051287"(NAD binding)|go:"GO:0098604"(adenosylselenohomocysteinase activity)|interpro:IPR000043(S-adenosyl-L-homocysteine hydrolase)|interpro:IPR015878(S-adenosyl-L-homocysteine hydrolase, NAD binding)|interpro:IPR020082|interpro:IPR036291|interpro:IPR042172|rcsb pdb:1B3R|rcsb pdb:1D4F|rcsb pdb:1K0U|rcsb pdb:1KY4|rcsb pdb:1KY5|rcsb pdb:1XWF|rcsb pdb:2H5L|reactome:R-RNO-156581|reactome:R-RNO-1614635|rgd:69260|refseq:NP_058897.1	-	-	-	caution:"The participant EBI-349571(P68370) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919386(Q7TP47) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920972(Q5XIP9) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-916419(P11980) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919578(Q8R491) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920554(Q5U3Z7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920647(Q5U2X8) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920585(Q7TP24) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-779677(P05426) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-915744(P02454) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|agonist:Insulin was shown to increase or decrease GLUT4 protein interactions in specific cases.|comment:"Insulin decreased GLUT4 interactions with the following proteins: Q9ER30 (Sarcosin), P09527 (Rab-7), O88960 (N-ethylmaleimide sensitive), P09456 (PKA I regulatory subunit), P27881 (Hexokinase type II), P07872 (Acyl-coenzyme A oxidase), Q6DGF1 (Isocitrate dehydrogenase), Q9EQX9 (Ubiquitin-conjugating), Q63446 (Polyubiquitin), P24268 (Cathepsin D), Q91XW0 (Heat shock protein 86), Q5FVH0 (unknown), P58405 (Striatin 3), Q62667 (Major vault protein), Q66H50 (unknown), Q09167 (splicing factor), Q9JHU5 (Arfaptin 1)."|comment:"Insulin increased GLUT4 interaction with the following proteins:Q9Z1P2 (R-actinin-1), P45592 (Cofilin), Q9QXQ0 (R-actinin-4), P26473 (ADP-ribosylation factor), P26437 (ADP-ribosylation factor),   Q7TNP1 (Basigin 2), Q6P6R2 (Dihydrolipoamide dehydrogenase),   P04797 (GAPDH), Q63081 (Protein disulfide isomerase), P29457 (47 kDa heat shock protein), Q9R1J8 (Leprecan), O88638 (Putative eps protein),   Q64375 (Synaptonemal complex)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:NDPK - Interactions involving proteins containing InterPro domain IPR001564, Nucleoside diphosphate kinase, core.	taxid:10116(rat-l6)|taxid:10116(Rattus norvegicus)	-	2006/02/15	2021/11/30	rogid:PbFY2lfrty8yw40Jq7ShR7xfuV410116	rogid:vFZ7nHj1DLY7rIDqieXpLKycLmQ10116	intact-crc:44F3A2176D02515F|rigid:9RVm0UBcqQF4k06RGKO89Bg16Q8	false	myc tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P19357	uniprotkb:P10719	intact:EBI-915426|uniprotkb:P97900|ensembl:ENSRNOP00000023256	intact:EBI-916266|uniprotkb:Q499W0	psi-mi:glut4_rat(display_long)|uniprotkb:Glucose transporter type 4, insulin-responsive(gene name synonym)|uniprotkb:Slc2a4(gene name)|psi-mi:Slc2a4(display_short)|uniprotkb:Glut4(gene name synonym)	psi-mi:atpb_rat(display_long)|uniprotkb:Atp5f1b(gene name)|psi-mi:Atp5f1b(display_short)|uniprotkb:ATP synthase F1 subunit beta(gene name synonym)|uniprotkb:Atp5b(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Foster et al. (2006)	pubmed:16396496|mint:MINT-5218203	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-921030	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2711|refseq:NP_036883.1|refseq:XP_006246658.1|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007611"(learning or memory)|go:"GO:0007614"(short-term memory)|go:"GO:0007616"(long-term memory)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010021"(amylopectin biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031550"(positive regulation of brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044381"(glucose import in response to insulin stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046323"(glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0098694"(regulation of synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0098793"(presynapse)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002441("Glucose transporter, type 4 (GLUT4)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-189200|ensembl:ENSRNOG00000017226(gene)|ensembl:ENSRNOT00000023256(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)	rgd:621368|refseq:NP_599191.1|interpro:IPR020003|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR004100(ATPase, F1/V1/A1 complex, alpha/beta subunit, N-terminal)|interpro:IPR000194(ATPase, F1/V1/A1 complex, alpha/beta subunit, nucleotide-binding)|interpro:IPR024034|interpro:IPR005722(ATPase, F1 complex, beta subunit)|go:"GO:0000275"("mitochondrial proton-transporting ATP synthase complex, catalytic sector F(1)")|go:"GO:0001525"(angiogenesis)|go:"GO:0001889"(liver development)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005753"(mitochondrial proton-transporting ATP synthase complex)|go:"GO:0005886"(plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0006754"(ATP biosynthetic process)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0006933"(negative regulation of cell adhesion involved in substrate-bound cell migration)|go:"GO:0009631"(cold acclimation)|go:"GO:0009986"(cell surface)|go:"GO:0010042"(response to manganese ion)|go:"GO:0016020"(membrane)|go:"GO:0030228"(lipoprotein particle receptor activity)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0042288"(MHC class I protein binding)|go:"GO:0042645"(mitochondrial nucleoid)|go:"GO:0042776"(mitochondrial ATP synthesis coupled proton transport)|go:"GO:0043531"(ADP binding)|go:"GO:0043532"(angiostatin binding)|go:"GO:0043536"(positive regulation of blood vessel endothelial cell migration)|go:"GO:0045121"(membrane raft)|go:"GO:0045259"(proton-transporting ATP synthase complex)|go:"GO:0045261"("proton-transporting ATP synthase complex, catalytic core F(1)")|go:"GO:0046034"(ATP metabolic process)|go:"GO:0046933"(proton-transporting ATP synthase activity, rotational mechanism)|go:"GO:0046961"(proton-transporting ATPase activity, rotational mechanism)|go:"GO:0051453"(regulation of intracellular pH)|go:"GO:0098761"(cellular response to interleukin-7)|go:"GO:1901653"(cellular response to peptide)|go:"GO:1902600"(proton transmembrane transport)|go:"GO:1904643"(response to curcumin)|go:"GO:1905242"(response to 3,3',5-triiodo-L-thyronine)|rcsb pdb:1MAB|rcsb pdb:2F43|reactome:R-RNO-1268020|reactome:R-RNO-163210|reactome:R-RNO-8949613|interpro:IPR027417|mint:P10719|interpro:IPR036121	-	-	-	caution:"The participant EBI-349571(P68370) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919386(Q7TP47) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920972(Q5XIP9) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-916419(P11980) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919578(Q8R491) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920554(Q5U3Z7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920647(Q5U2X8) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920585(Q7TP24) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-779677(P05426) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-915744(P02454) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|agonist:Insulin was shown to increase or decrease GLUT4 protein interactions in specific cases.|comment:"Insulin decreased GLUT4 interactions with the following proteins: Q9ER30 (Sarcosin), P09527 (Rab-7), O88960 (N-ethylmaleimide sensitive), P09456 (PKA I regulatory subunit), P27881 (Hexokinase type II), P07872 (Acyl-coenzyme A oxidase), Q6DGF1 (Isocitrate dehydrogenase), Q9EQX9 (Ubiquitin-conjugating), Q63446 (Polyubiquitin), P24268 (Cathepsin D), Q91XW0 (Heat shock protein 86), Q5FVH0 (unknown), P58405 (Striatin 3), Q62667 (Major vault protein), Q66H50 (unknown), Q09167 (splicing factor), Q9JHU5 (Arfaptin 1)."|comment:"Insulin increased GLUT4 interaction with the following proteins:Q9Z1P2 (R-actinin-1), P45592 (Cofilin), Q9QXQ0 (R-actinin-4), P26473 (ADP-ribosylation factor), P26437 (ADP-ribosylation factor),   Q7TNP1 (Basigin 2), Q6P6R2 (Dihydrolipoamide dehydrogenase),   P04797 (GAPDH), Q63081 (Protein disulfide isomerase), P29457 (47 kDa heat shock protein), Q9R1J8 (Leprecan), O88638 (Putative eps protein),   Q64375 (Synaptonemal complex)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:NDPK - Interactions involving proteins containing InterPro domain IPR001564, Nucleoside diphosphate kinase, core.	taxid:10116(rat-l6)|taxid:10116(Rattus norvegicus)	-	2006/02/15	2021/11/30	rogid:PbFY2lfrty8yw40Jq7ShR7xfuV410116	rogid:K1RREEkTYSnEnU2leNpq3SCa3wc10116	intact-crc:44F3A2176D02515F|rigid:9RVm0UBcqQF4k06RGKO89Bg16Q8	false	myc tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P19357	uniprotkb:P62755	intact:EBI-915426|uniprotkb:P97900|ensembl:ENSRNOP00000023256	intact:EBI-356605|uniprotkb:P10660|uniprotkb:P08227	psi-mi:glut4_rat(display_long)|uniprotkb:Glucose transporter type 4, insulin-responsive(gene name synonym)|uniprotkb:Slc2a4(gene name)|psi-mi:Slc2a4(display_short)|uniprotkb:Glut4(gene name synonym)	psi-mi:rs6_rat(display_long)|uniprotkb:Rps6(gene name)|psi-mi:Rps6(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Foster et al. (2006)	pubmed:16396496|mint:MINT-5218203	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-921030	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2711|refseq:NP_036883.1|refseq:XP_006246658.1|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007611"(learning or memory)|go:"GO:0007614"(short-term memory)|go:"GO:0007616"(long-term memory)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010021"(amylopectin biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031550"(positive regulation of brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044381"(glucose import in response to insulin stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046323"(glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0098694"(regulation of synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0098793"(presynapse)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002441("Glucose transporter, type 4 (GLUT4)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-189200|ensembl:ENSRNOG00000017226(gene)|ensembl:ENSRNOT00000023256(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)	rgd:3602|refseq:NP_058856.1|interpro:IPR014401(Ribosomal protein S6, eukaryotic)|interpro:IPR001377(Ribosomal protein S6e)|interpro:IPR018282|refseq:XP_003750019.1|go:"GO:0044297"(cell body)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048821"(erythrocyte development)|go:"GO:0071361"(cellular response to ethanol)|go:"GO:1903347"(negative regulation of bicellular tight junction assembly)|go:"GO:1990904"(ribonucleoprotein complex)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0001890"(placenta development)|go:"GO:0002309"(T cell proliferation involved in immune response)|go:"GO:0003729"(mRNA binding)|go:"GO:0003735"(structural constituent of ribosome)|go:"GO:0005634"(nucleus)|go:"GO:0000028"(ribosomal small subunit assembly)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005840"(ribosome)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0005844"(polysome)|go:"GO:0006364"(rRNA processing)|go:"GO:0006412"(translation)|go:"GO:0006924"(activation-induced cell death of T cells)|go:"GO:0007369"(gastrulation)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0015935"(small ribosomal subunit)|go:"GO:0019901"(protein kinase binding)|go:"GO:0022605"(mammalian oogenesis stage)|go:"GO:0022626"(cytosolic ribosome)|go:"GO:0022627"(cytosolic small ribosomal subunit)|go:"GO:0030425"(dendrite)|go:"GO:0031929"(TOR signaling)|go:"GO:0032868"(response to insulin)|go:"GO:0033077"(T cell differentiation in thymus)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042274"(ribosomal small subunit biogenesis)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043065"(positive regulation of apoptotic process)|reactome:R-RNO-156827|reactome:R-RNO-166208|reactome:R-RNO-1799339|reactome:R-RNO-6791226|reactome:R-RNO-72649|reactome:R-RNO-72689|reactome:R-RNO-72695|reactome:R-RNO-72702|reactome:R-RNO-72706|reactome:R-RNO-975956|reactome:R-RNO-975957	-	-	-	caution:"The participant EBI-349571(P68370) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919386(Q7TP47) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920972(Q5XIP9) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-916419(P11980) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919578(Q8R491) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920554(Q5U3Z7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920647(Q5U2X8) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920585(Q7TP24) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-779677(P05426) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-915744(P02454) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|agonist:Insulin was shown to increase or decrease GLUT4 protein interactions in specific cases.|comment:"Insulin decreased GLUT4 interactions with the following proteins: Q9ER30 (Sarcosin), P09527 (Rab-7), O88960 (N-ethylmaleimide sensitive), P09456 (PKA I regulatory subunit), P27881 (Hexokinase type II), P07872 (Acyl-coenzyme A oxidase), Q6DGF1 (Isocitrate dehydrogenase), Q9EQX9 (Ubiquitin-conjugating), Q63446 (Polyubiquitin), P24268 (Cathepsin D), Q91XW0 (Heat shock protein 86), Q5FVH0 (unknown), P58405 (Striatin 3), Q62667 (Major vault protein), Q66H50 (unknown), Q09167 (splicing factor), Q9JHU5 (Arfaptin 1)."|comment:"Insulin increased GLUT4 interaction with the following proteins:Q9Z1P2 (R-actinin-1), P45592 (Cofilin), Q9QXQ0 (R-actinin-4), P26473 (ADP-ribosylation factor), P26437 (ADP-ribosylation factor),   Q7TNP1 (Basigin 2), Q6P6R2 (Dihydrolipoamide dehydrogenase),   P04797 (GAPDH), Q63081 (Protein disulfide isomerase), P29457 (47 kDa heat shock protein), Q9R1J8 (Leprecan), O88638 (Putative eps protein),   Q64375 (Synaptonemal complex)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:NDPK - Interactions involving proteins containing InterPro domain IPR001564, Nucleoside diphosphate kinase, core.	taxid:10116(rat-l6)|taxid:10116(Rattus norvegicus)	-	2006/02/15	2021/11/30	rogid:PbFY2lfrty8yw40Jq7ShR7xfuV410116	rogid:beDuXCIqL99V9JlVfpzx7MdpH6810116	intact-crc:44F3A2176D02515F|rigid:9RVm0UBcqQF4k06RGKO89Bg16Q8	false	myc tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P19357	uniprotkb:P10536	intact:EBI-915426|uniprotkb:P97900|ensembl:ENSRNOP00000023256	intact:EBI-916259	psi-mi:glut4_rat(display_long)|uniprotkb:Glucose transporter type 4, insulin-responsive(gene name synonym)|uniprotkb:Slc2a4(gene name)|psi-mi:Slc2a4(display_short)|uniprotkb:Glut4(gene name synonym)	psi-mi:rab1b_rat(display_long)|uniprotkb:Rab1b(gene name)|psi-mi:Rab1b(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Foster et al. (2006)	pubmed:16396496|mint:MINT-5218203	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-921030	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2711|refseq:NP_036883.1|refseq:XP_006246658.1|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007611"(learning or memory)|go:"GO:0007614"(short-term memory)|go:"GO:0007616"(long-term memory)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010021"(amylopectin biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031550"(positive regulation of brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044381"(glucose import in response to insulin stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046323"(glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0098694"(regulation of synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0098793"(presynapse)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002441("Glucose transporter, type 4 (GLUT4)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-189200|ensembl:ENSRNOG00000017226(gene)|ensembl:ENSRNOT00000023256(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)	go:"GO:0000045"(autophagosome assembly)|go:"GO:0003924"(GTPase activity)|go:"GO:0003925"(G protein activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005793"(endoplasmic reticulum-Golgi intermediate compartment)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006888"(endoplasmic reticulum to Golgi vesicle-mediated transport)|go:"GO:0012505"(endomembrane system)|go:"GO:0019068"(virion assembly)|go:"GO:0034045"(phagophore assembly site membrane)|go:"GO:0045202"(synapse)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:1903020"(positive regulation of glycoprotein metabolic process)|go:"GO:2000785"(regulation of autophagosome assembly)|reactome:R-RNO-162658|reactome:R-RNO-204005|reactome:R-RNO-6807878|reactome:R-RNO-6811434|reactome:R-RNO-8873719|reactome:R-RNO-8876198|mint:P10536|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR001806(Ras GTPase)|interpro:IPR027417|rgd:1642882	-	-	-	caution:"The participant EBI-349571(P68370) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919386(Q7TP47) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920972(Q5XIP9) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-916419(P11980) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919578(Q8R491) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920554(Q5U3Z7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920647(Q5U2X8) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920585(Q7TP24) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-779677(P05426) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-915744(P02454) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|agonist:Insulin was shown to increase or decrease GLUT4 protein interactions in specific cases.|comment:"Insulin decreased GLUT4 interactions with the following proteins: Q9ER30 (Sarcosin), P09527 (Rab-7), O88960 (N-ethylmaleimide sensitive), P09456 (PKA I regulatory subunit), P27881 (Hexokinase type II), P07872 (Acyl-coenzyme A oxidase), Q6DGF1 (Isocitrate dehydrogenase), Q9EQX9 (Ubiquitin-conjugating), Q63446 (Polyubiquitin), P24268 (Cathepsin D), Q91XW0 (Heat shock protein 86), Q5FVH0 (unknown), P58405 (Striatin 3), Q62667 (Major vault protein), Q66H50 (unknown), Q09167 (splicing factor), Q9JHU5 (Arfaptin 1)."|comment:"Insulin increased GLUT4 interaction with the following proteins:Q9Z1P2 (R-actinin-1), P45592 (Cofilin), Q9QXQ0 (R-actinin-4), P26473 (ADP-ribosylation factor), P26437 (ADP-ribosylation factor),   Q7TNP1 (Basigin 2), Q6P6R2 (Dihydrolipoamide dehydrogenase),   P04797 (GAPDH), Q63081 (Protein disulfide isomerase), P29457 (47 kDa heat shock protein), Q9R1J8 (Leprecan), O88638 (Putative eps protein),   Q64375 (Synaptonemal complex)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:NDPK - Interactions involving proteins containing InterPro domain IPR001564, Nucleoside diphosphate kinase, core.	taxid:10116(rat-l6)|taxid:10116(Rattus norvegicus)	-	2006/02/15	2021/11/30	rogid:PbFY2lfrty8yw40Jq7ShR7xfuV410116	rogid:38K2G7MLSF0vWuSRaxk2wbqmqwI10116	intact-crc:44F3A2176D02515F|rigid:9RVm0UBcqQF4k06RGKO89Bg16Q8	false	myc tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P19357	uniprotkb:P63326	intact:EBI-915426|uniprotkb:P97900|ensembl:ENSRNOP00000023256	intact:EBI-916252|ensembl:ENSRNOP00000043693|uniprotkb:P09900|uniprotkb:Q9DCR5	psi-mi:glut4_rat(display_long)|uniprotkb:Glucose transporter type 4, insulin-responsive(gene name synonym)|uniprotkb:Slc2a4(gene name)|psi-mi:Slc2a4(display_short)|uniprotkb:Glut4(gene name synonym)	psi-mi:rs10_rat(display_long)|uniprotkb:Rps10(gene name)|psi-mi:Rps10(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Foster et al. (2006)	pubmed:16396496|mint:MINT-5218203	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-921030	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2711|refseq:NP_036883.1|refseq:XP_006246658.1|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007611"(learning or memory)|go:"GO:0007614"(short-term memory)|go:"GO:0007616"(long-term memory)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010021"(amylopectin biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031550"(positive regulation of brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044381"(glucose import in response to insulin stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046323"(glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0098694"(regulation of synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0098793"(presynapse)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002441("Glucose transporter, type 4 (GLUT4)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-189200|ensembl:ENSRNOG00000017226(gene)|ensembl:ENSRNOT00000023256(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)	ensembl:ENSRNOG00000052141(gene)|ensembl:ENSRNOT00000043250(transcript)|go:"GO:0000028"(ribosomal small subunit assembly)|go:"GO:0000049"(tRNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003735"(structural constituent of ribosome)|go:"GO:0005730"(nucleolus)|go:"GO:0022626"(cytosolic ribosome)|go:"GO:0022627"(cytosolic small ribosomal subunit)|interpro:IPR005326(Plectin/S10, N-terminal)|interpro:IPR036388|interpro:IPR037447|mint:P63326|reactome:R-RNO-156827|reactome:R-RNO-1799339|reactome:R-RNO-6791226|reactome:R-RNO-72649|reactome:R-RNO-72689|reactome:R-RNO-72695|reactome:R-RNO-72702|reactome:R-RNO-72706|reactome:R-RNO-975956|reactome:R-RNO-975957|refseq:XP_003754221.1|rgd:621024|refseq:NP_112371.1|refseq:XP_002729669.1	-	-	-	caution:"The participant EBI-349571(P68370) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919386(Q7TP47) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920972(Q5XIP9) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-916419(P11980) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919578(Q8R491) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920554(Q5U3Z7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920647(Q5U2X8) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920585(Q7TP24) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-779677(P05426) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-915744(P02454) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|agonist:Insulin was shown to increase or decrease GLUT4 protein interactions in specific cases.|comment:"Insulin decreased GLUT4 interactions with the following proteins: Q9ER30 (Sarcosin), P09527 (Rab-7), O88960 (N-ethylmaleimide sensitive), P09456 (PKA I regulatory subunit), P27881 (Hexokinase type II), P07872 (Acyl-coenzyme A oxidase), Q6DGF1 (Isocitrate dehydrogenase), Q9EQX9 (Ubiquitin-conjugating), Q63446 (Polyubiquitin), P24268 (Cathepsin D), Q91XW0 (Heat shock protein 86), Q5FVH0 (unknown), P58405 (Striatin 3), Q62667 (Major vault protein), Q66H50 (unknown), Q09167 (splicing factor), Q9JHU5 (Arfaptin 1)."|comment:"Insulin increased GLUT4 interaction with the following proteins:Q9Z1P2 (R-actinin-1), P45592 (Cofilin), Q9QXQ0 (R-actinin-4), P26473 (ADP-ribosylation factor), P26437 (ADP-ribosylation factor),   Q7TNP1 (Basigin 2), Q6P6R2 (Dihydrolipoamide dehydrogenase),   P04797 (GAPDH), Q63081 (Protein disulfide isomerase), P29457 (47 kDa heat shock protein), Q9R1J8 (Leprecan), O88638 (Putative eps protein),   Q64375 (Synaptonemal complex)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:NDPK - Interactions involving proteins containing InterPro domain IPR001564, Nucleoside diphosphate kinase, core.	taxid:10116(rat-l6)|taxid:10116(Rattus norvegicus)	-	2006/02/15	2021/11/30	rogid:PbFY2lfrty8yw40Jq7ShR7xfuV410116	rogid:XN7SjnIc8XsuJiY6/WulloSN//010116	intact-crc:44F3A2176D02515F|rigid:9RVm0UBcqQF4k06RGKO89Bg16Q8	false	myc tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P19357	uniprotkb:P09895	intact:EBI-915426|uniprotkb:P97900|ensembl:ENSRNOP00000023256	intact:EBI-916235|ensembl:ENSRNOP00000036514	psi-mi:glut4_rat(display_long)|uniprotkb:Glucose transporter type 4, insulin-responsive(gene name synonym)|uniprotkb:Slc2a4(gene name)|psi-mi:Slc2a4(display_short)|uniprotkb:Glut4(gene name synonym)	psi-mi:rl5_rat(display_long)|uniprotkb:Rpl5(gene name)|psi-mi:Rpl5(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Foster et al. (2006)	pubmed:16396496|mint:MINT-5218203	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-921030	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2711|refseq:NP_036883.1|refseq:XP_006246658.1|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007611"(learning or memory)|go:"GO:0007614"(short-term memory)|go:"GO:0007616"(long-term memory)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010021"(amylopectin biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031550"(positive regulation of brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044381"(glucose import in response to insulin stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046323"(glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0098694"(regulation of synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0098793"(presynapse)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002441("Glucose transporter, type 4 (GLUT4)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-189200|ensembl:ENSRNOG00000017226(gene)|ensembl:ENSRNOT00000023256(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)	go:"GO:0000027"(ribosomal large subunit assembly)|go:"GO:0003729"(mRNA binding)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0003735"(structural constituent of ribosome)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006364"(rRNA processing)|go:"GO:0006412"(translation)|go:"GO:0008097"(5S rRNA binding)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010922"(positive regulation of phosphatase activity)|go:"GO:0014069"(postsynaptic density)|go:"GO:0017101"(aminoacyl-tRNA synthetase multienzyme complex)|go:"GO:0022625"(cytosolic large ribosomal subunit)|go:"GO:0022626"(cytosolic ribosome)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042273"(ribosomal large subunit biogenesis)|go:"GO:0045202"(synapse)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0048027"(mRNA 5'-UTR binding)|go:"GO:0050821"(protein stabilization)|go:"GO:0071241"(cellular response to inorganic substance)|go:"GO:1901796"(regulation of signal transduction by p53 class mediator)|ensembl:ENSRNOG00000023529(gene)|ensembl:ENSRNOT00000030428(transcript)|go:"GO:1904667"(negative regulation of ubiquitin protein ligase activity)|go:"GO:1905017"(positive regulation of isoleucine-tRNA ligase activity)|go:"GO:1905020"(positive regulation of methionine-tRNA ligase activity)|go:"GO:1905023"(positive regulation of threonine-tRNA ligase activity)|go:"GO:1990904"(ribonucleoprotein complex)|go:"GO:1990948"(ubiquitin ligase inhibitor activity)|go:"GO:2000059"(negative regulation of ubiquitin-dependent protein catabolic process)|go:"GO:2000435"(negative regulation of protein neddylation)|interpro:IPR005485(Ribosomal protein L5, eukaryotic)|interpro:IPR025607|reactome:R-RNO-156827|reactome:R-RNO-1799339|reactome:R-RNO-6791226|reactome:R-RNO-72689|reactome:R-RNO-72706|reactome:R-RNO-975956|reactome:R-RNO-975957|rgd:619825|refseq:NP_112361.1|refseq:XP_006250647.1	-	-	-	caution:"The participant EBI-349571(P68370) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919386(Q7TP47) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920972(Q5XIP9) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-916419(P11980) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919578(Q8R491) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920554(Q5U3Z7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920647(Q5U2X8) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920585(Q7TP24) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-779677(P05426) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-915744(P02454) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|agonist:Insulin was shown to increase or decrease GLUT4 protein interactions in specific cases.|comment:"Insulin decreased GLUT4 interactions with the following proteins: Q9ER30 (Sarcosin), P09527 (Rab-7), O88960 (N-ethylmaleimide sensitive), P09456 (PKA I regulatory subunit), P27881 (Hexokinase type II), P07872 (Acyl-coenzyme A oxidase), Q6DGF1 (Isocitrate dehydrogenase), Q9EQX9 (Ubiquitin-conjugating), Q63446 (Polyubiquitin), P24268 (Cathepsin D), Q91XW0 (Heat shock protein 86), Q5FVH0 (unknown), P58405 (Striatin 3), Q62667 (Major vault protein), Q66H50 (unknown), Q09167 (splicing factor), Q9JHU5 (Arfaptin 1)."|comment:"Insulin increased GLUT4 interaction with the following proteins:Q9Z1P2 (R-actinin-1), P45592 (Cofilin), Q9QXQ0 (R-actinin-4), P26473 (ADP-ribosylation factor), P26437 (ADP-ribosylation factor),   Q7TNP1 (Basigin 2), Q6P6R2 (Dihydrolipoamide dehydrogenase),   P04797 (GAPDH), Q63081 (Protein disulfide isomerase), P29457 (47 kDa heat shock protein), Q9R1J8 (Leprecan), O88638 (Putative eps protein),   Q64375 (Synaptonemal complex)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:NDPK - Interactions involving proteins containing InterPro domain IPR001564, Nucleoside diphosphate kinase, core.	taxid:10116(rat-l6)|taxid:10116(Rattus norvegicus)	-	2006/02/15	2021/11/30	rogid:PbFY2lfrty8yw40Jq7ShR7xfuV410116	rogid:bHwz+Hrnj2WrluOBLeRe7xi9Z0010116	intact-crc:44F3A2176D02515F|rigid:9RVm0UBcqQF4k06RGKO89Bg16Q8	false	myc tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P19357	uniprotkb:P09527	intact:EBI-915426|uniprotkb:P97900|ensembl:ENSRNOP00000023256	intact:EBI-916225|uniprotkb:Q4AEF6|ensembl:ENSRNOP00000016432	psi-mi:glut4_rat(display_long)|uniprotkb:Glucose transporter type 4, insulin-responsive(gene name synonym)|uniprotkb:Slc2a4(gene name)|psi-mi:Slc2a4(display_short)|uniprotkb:Glut4(gene name synonym)	psi-mi:rab7a_rat(display_long)|uniprotkb:Rab7a(gene name)|psi-mi:Rab7a(display_short)|uniprotkb:Ras-related protein p23(gene name synonym)|uniprotkb:Ras-related protein BRL-RAS(gene name synonym)|uniprotkb:Rab7(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Foster et al. (2006)	pubmed:16396496|mint:MINT-5218203	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-921030	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2711|refseq:NP_036883.1|refseq:XP_006246658.1|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007611"(learning or memory)|go:"GO:0007614"(short-term memory)|go:"GO:0007616"(long-term memory)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010021"(amylopectin biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031550"(positive regulation of brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044381"(glucose import in response to insulin stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046323"(glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0098694"(regulation of synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0098793"(presynapse)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002441("Glucose transporter, type 4 (GLUT4)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-189200|ensembl:ENSRNOG00000017226(gene)|ensembl:ENSRNOT00000023256(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)	rgd:61908|refseq:NP_076440.1|ensembl:ENSRNOG00000012247(gene)|ensembl:ENSRNOT00000016432(transcript)|go:"GO:0000045"(autophagosome assembly)|go:"GO:0000421"(autophagosome membrane)|go:"GO:0003924"(GTPase activity)|go:"GO:0003925"(G protein activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005768"(endosome)|go:"GO:0005770"(late endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005811"(lipid droplet)|go:"GO:0005829"(cytosol)|go:"GO:0006622"(protein targeting to lysosome)|go:"GO:0007174"(epidermal growth factor catabolic process)|go:"GO:0008333"(endosome to lysosome transport)|go:"GO:0010008"(endosome membrane)|go:"GO:0016042"(lipid catabolic process)|go:"GO:0019003"(GDP binding)|go:"GO:0019076"(viral release from host cell)|go:"GO:0022615"(protein to membrane docking)|go:"GO:0030670"(phagocytic vesicle membrane)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031902"(late endosome membrane)|go:"GO:0032419"(extrinsic component of lysosome membrane)|go:"GO:0033162"(melanosome membrane)|go:"GO:0034045"(phagophore assembly site membrane)|go:"GO:0042147"(retrograde transport, endosome to Golgi)|go:"GO:0043195"(terminal bouton)|go:"GO:0045022"(early endosome to late endosome transport)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0045453"(bone resorption)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0048524"(positive regulation of viral process)|go:"GO:0051650"(establishment of vesicle localization)|go:"GO:0061724"(lipophagy)|go:"GO:0090383"(phagosome acidification)|go:"GO:0090385"(phagosome-lysosome fusion)|go:"GO:0097208"(alveolar lamellar body)|go:"GO:0098993"(anchored component of synaptic vesicle membrane)|go:"GO:0099638"(endosome to plasma membrane protein transport)|go:"GO:1903542"(negative regulation of exosomal secretion)|go:"GO:1903543"(positive regulation of exosomal secretion)|go:"GO:1905394"(retromer complex binding)|interpro:IPR001806(Ras GTPase)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR027417|mint:P09527|rcsb pdb:1VG0|rcsb pdb:1VG1|rcsb pdb:1VG8|rcsb pdb:1VG9|reactome:R-RNO-2132295|reactome:R-RNO-6798695|reactome:R-RNO-8854214|reactome:R-RNO-8873719|reactome:R-RNO-8876198|reactome:R-RNO-9013148|reactome:R-RNO-9013149|reactome:R-RNO-9013404|reactome:R-RNO-9013405|reactome:R-RNO-9013406|reactome:R-RNO-9013407|reactome:R-RNO-9013408|reactome:R-RNO-9013423|reactome:R-RNO-9035034|refseq:XP_006236911.1	-	-	-	caution:"The participant EBI-349571(P68370) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919386(Q7TP47) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920972(Q5XIP9) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-916419(P11980) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919578(Q8R491) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920554(Q5U3Z7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920647(Q5U2X8) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920585(Q7TP24) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-779677(P05426) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-915744(P02454) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|agonist:Insulin was shown to increase or decrease GLUT4 protein interactions in specific cases.|comment:"Insulin decreased GLUT4 interactions with the following proteins: Q9ER30 (Sarcosin), P09527 (Rab-7), O88960 (N-ethylmaleimide sensitive), P09456 (PKA I regulatory subunit), P27881 (Hexokinase type II), P07872 (Acyl-coenzyme A oxidase), Q6DGF1 (Isocitrate dehydrogenase), Q9EQX9 (Ubiquitin-conjugating), Q63446 (Polyubiquitin), P24268 (Cathepsin D), Q91XW0 (Heat shock protein 86), Q5FVH0 (unknown), P58405 (Striatin 3), Q62667 (Major vault protein), Q66H50 (unknown), Q09167 (splicing factor), Q9JHU5 (Arfaptin 1)."|comment:"Insulin increased GLUT4 interaction with the following proteins:Q9Z1P2 (R-actinin-1), P45592 (Cofilin), Q9QXQ0 (R-actinin-4), P26473 (ADP-ribosylation factor), P26437 (ADP-ribosylation factor),   Q7TNP1 (Basigin 2), Q6P6R2 (Dihydrolipoamide dehydrogenase),   P04797 (GAPDH), Q63081 (Protein disulfide isomerase), P29457 (47 kDa heat shock protein), Q9R1J8 (Leprecan), O88638 (Putative eps protein),   Q64375 (Synaptonemal complex)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:NDPK - Interactions involving proteins containing InterPro domain IPR001564, Nucleoside diphosphate kinase, core.	taxid:10116(rat-l6)|taxid:10116(Rattus norvegicus)	-	2006/02/15	2021/11/30	rogid:PbFY2lfrty8yw40Jq7ShR7xfuV410116	rogid:lppyS2rWzk4Iax3nOHVdHiA0ceg10116	intact-crc:44F3A2176D02515F|rigid:9RVm0UBcqQF4k06RGKO89Bg16Q8	false	myc tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P19357	uniprotkb:P09456	intact:EBI-915426|uniprotkb:P97900|ensembl:ENSRNOP00000023256	intact:EBI-916215|ensembl:ENSRNOP00000067771	psi-mi:glut4_rat(display_long)|uniprotkb:Glucose transporter type 4, insulin-responsive(gene name synonym)|uniprotkb:Slc2a4(gene name)|psi-mi:Slc2a4(display_short)|uniprotkb:Glut4(gene name synonym)	psi-mi:kap0_rat(display_long)|uniprotkb:Prkar1a(gene name)|psi-mi:Prkar1a(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Foster et al. (2006)	pubmed:16396496|mint:MINT-5218203	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-921030	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2711|refseq:NP_036883.1|refseq:XP_006246658.1|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007611"(learning or memory)|go:"GO:0007614"(short-term memory)|go:"GO:0007616"(long-term memory)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010021"(amylopectin biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031550"(positive regulation of brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044381"(glucose import in response to insulin stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046323"(glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0098694"(regulation of synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0098793"(presynapse)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002441("Glucose transporter, type 4 (GLUT4)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-189200|ensembl:ENSRNOG00000017226(gene)|ensembl:ENSRNOT00000023256(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)	rgd:3391|refseq:NP_037313.1|go:"GO:0060038"(cardiac muscle cell proliferation)|go:"GO:0097224"(sperm connecting piece)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:2000480"(negative regulation of cAMP-dependent protein kinase activity)|interpro:IPR000595(Cyclic nucleotide-binding)|interpro:IPR003117(cAMP-dependent protein kinase, regulatory subunit, type I/II alpha/beta)|interpro:IPR014710(RmlC-like jelly roll fold)|interpro:IPR018488|interpro:IPR018490|reactome:R-RNO-163615|reactome:R-RNO-164378|reactome:R-RNO-180024|reactome:R-RNO-432040|reactome:R-RNO-442720|reactome:R-RNO-5610787|reactome:R-RNO-983231|ensembl:ENSRNOG00000049876(gene)|ensembl:ENSRNOT00000071153(transcript)|go:"GO:0001707"(mesoderm formation)|go:"GO:0001772"(immunological synapse)|go:"GO:0004862"(cAMP-dependent protein kinase inhibitor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005771"(multivesicular body)|go:"GO:0005813"(centrosome)|go:"GO:0005930"(axoneme)|go:"GO:0005952"(cAMP-dependent protein kinase complex)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0007143"(female meiotic nuclear division)|go:"GO:0007507"(heart development)|go:"GO:0008603"(cAMP-dependent protein kinase regulator activity)|go:"GO:0010738"(regulation of protein kinase A signaling)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030552"(cAMP binding)|go:"GO:0031588"(nucleotide-activated protein kinase complex)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0034236"(protein kinase A catalytic subunit binding)|go:"GO:0043949"(regulation of cAMP-mediated signaling)|go:"GO:0044853"(plasma membrane raft)|go:"GO:0045202"(synapse)|go:"GO:0045214"(sarcomere organization)|go:"GO:0045835"(negative regulation of meiotic nuclear division)|go:"GO:0045859"(regulation of protein kinase activity)|go:"GO:0046007"(negative regulation of activated T cell proliferation)|refseq:XP_008766533.1|refseq:XP_017452536.1	-	-	-	caution:"The participant EBI-349571(P68370) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919386(Q7TP47) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920972(Q5XIP9) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-916419(P11980) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919578(Q8R491) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920554(Q5U3Z7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920647(Q5U2X8) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920585(Q7TP24) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-779677(P05426) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-915744(P02454) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|agonist:Insulin was shown to increase or decrease GLUT4 protein interactions in specific cases.|comment:"Insulin decreased GLUT4 interactions with the following proteins: Q9ER30 (Sarcosin), P09527 (Rab-7), O88960 (N-ethylmaleimide sensitive), P09456 (PKA I regulatory subunit), P27881 (Hexokinase type II), P07872 (Acyl-coenzyme A oxidase), Q6DGF1 (Isocitrate dehydrogenase), Q9EQX9 (Ubiquitin-conjugating), Q63446 (Polyubiquitin), P24268 (Cathepsin D), Q91XW0 (Heat shock protein 86), Q5FVH0 (unknown), P58405 (Striatin 3), Q62667 (Major vault protein), Q66H50 (unknown), Q09167 (splicing factor), Q9JHU5 (Arfaptin 1)."|comment:"Insulin increased GLUT4 interaction with the following proteins:Q9Z1P2 (R-actinin-1), P45592 (Cofilin), Q9QXQ0 (R-actinin-4), P26473 (ADP-ribosylation factor), P26437 (ADP-ribosylation factor),   Q7TNP1 (Basigin 2), Q6P6R2 (Dihydrolipoamide dehydrogenase),   P04797 (GAPDH), Q63081 (Protein disulfide isomerase), P29457 (47 kDa heat shock protein), Q9R1J8 (Leprecan), O88638 (Putative eps protein),   Q64375 (Synaptonemal complex)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:NDPK - Interactions involving proteins containing InterPro domain IPR001564, Nucleoside diphosphate kinase, core.	taxid:10116(rat-l6)|taxid:10116(Rattus norvegicus)	-	2006/02/15	2021/11/30	rogid:PbFY2lfrty8yw40Jq7ShR7xfuV410116	rogid:nGBB094hlb7YlbgO+DYsOaikgjk10116	intact-crc:44F3A2176D02515F|rigid:9RVm0UBcqQF4k06RGKO89Bg16Q8	false	myc tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P19357	uniprotkb:P63324	intact:EBI-915426|uniprotkb:P97900|ensembl:ENSRNOP00000023256	intact:EBI-916207|uniprotkb:P09388|uniprotkb:P12728	psi-mi:glut4_rat(display_long)|uniprotkb:Glucose transporter type 4, insulin-responsive(gene name synonym)|uniprotkb:Slc2a4(gene name)|psi-mi:Slc2a4(display_short)|uniprotkb:Glut4(gene name synonym)	psi-mi:rs12_rat(display_long)|uniprotkb:Rps12(gene name)|psi-mi:Rps12(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Foster et al. (2006)	pubmed:16396496|mint:MINT-5218203	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-921030	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2711|refseq:NP_036883.1|refseq:XP_006246658.1|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007611"(learning or memory)|go:"GO:0007614"(short-term memory)|go:"GO:0007616"(long-term memory)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010021"(amylopectin biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031550"(positive regulation of brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044381"(glucose import in response to insulin stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046323"(glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0098694"(regulation of synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0098793"(presynapse)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002441("Glucose transporter, type 4 (GLUT4)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-189200|ensembl:ENSRNOG00000017226(gene)|ensembl:ENSRNOT00000023256(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)	interpro:IPR004038(Ribosomal protein L7Ae/L30e/S12e/Gadd45)|interpro:IPR000530(Ribosomal protein S12e)|rgd:62024|go:"GO:0003735"(structural constituent of ribosome)|go:"GO:0006412"(translation)|go:"GO:0010243"(response to organonitrogen compound)|go:"GO:0022625"(cytosolic large ribosomal subunit)|go:"GO:0022626"(cytosolic ribosome)|go:"GO:0022627"(cytosolic small ribosomal subunit)|interpro:IPR029064|reactome:R-RNO-156827|reactome:R-RNO-1799339|reactome:R-RNO-6791226|reactome:R-RNO-72649|reactome:R-RNO-72689|reactome:R-RNO-72695|reactome:R-RNO-72702|reactome:R-RNO-72706|reactome:R-RNO-975956|reactome:R-RNO-975957	-	-	-	caution:"The participant EBI-349571(P68370) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919386(Q7TP47) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920972(Q5XIP9) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-916419(P11980) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919578(Q8R491) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920554(Q5U3Z7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920647(Q5U2X8) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920585(Q7TP24) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-779677(P05426) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-915744(P02454) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|agonist:Insulin was shown to increase or decrease GLUT4 protein interactions in specific cases.|comment:"Insulin decreased GLUT4 interactions with the following proteins: Q9ER30 (Sarcosin), P09527 (Rab-7), O88960 (N-ethylmaleimide sensitive), P09456 (PKA I regulatory subunit), P27881 (Hexokinase type II), P07872 (Acyl-coenzyme A oxidase), Q6DGF1 (Isocitrate dehydrogenase), Q9EQX9 (Ubiquitin-conjugating), Q63446 (Polyubiquitin), P24268 (Cathepsin D), Q91XW0 (Heat shock protein 86), Q5FVH0 (unknown), P58405 (Striatin 3), Q62667 (Major vault protein), Q66H50 (unknown), Q09167 (splicing factor), Q9JHU5 (Arfaptin 1)."|comment:"Insulin increased GLUT4 interaction with the following proteins:Q9Z1P2 (R-actinin-1), P45592 (Cofilin), Q9QXQ0 (R-actinin-4), P26473 (ADP-ribosylation factor), P26437 (ADP-ribosylation factor),   Q7TNP1 (Basigin 2), Q6P6R2 (Dihydrolipoamide dehydrogenase),   P04797 (GAPDH), Q63081 (Protein disulfide isomerase), P29457 (47 kDa heat shock protein), Q9R1J8 (Leprecan), O88638 (Putative eps protein),   Q64375 (Synaptonemal complex)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:NDPK - Interactions involving proteins containing InterPro domain IPR001564, Nucleoside diphosphate kinase, core.	taxid:10116(rat-l6)|taxid:10116(Rattus norvegicus)	-	2006/02/15	2021/11/30	rogid:PbFY2lfrty8yw40Jq7ShR7xfuV410116	rogid:7aksQ5txpDO0RK6Wroe/gCuWwj410116	intact-crc:44F3A2176D02515F|rigid:9RVm0UBcqQF4k06RGKO89Bg16Q8	false	myc tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P19357	uniprotkb:P09330	intact:EBI-915426|uniprotkb:P97900|ensembl:ENSRNOP00000023256	intact:EBI-916191|uniprotkb:Q63462|ensembl:ENSRNOP00000005615	psi-mi:glut4_rat(display_long)|uniprotkb:Glucose transporter type 4, insulin-responsive(gene name synonym)|uniprotkb:Slc2a4(gene name)|psi-mi:Slc2a4(display_short)|uniprotkb:Glut4(gene name synonym)	psi-mi:prps2_rat(display_long)|uniprotkb:Prps2(gene name)|psi-mi:Prps2(display_short)|uniprotkb:Phosphoribosyl pyrophosphate synthase II(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Foster et al. (2006)	pubmed:16396496|mint:MINT-5218203	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-921030	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2711|refseq:NP_036883.1|refseq:XP_006246658.1|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007611"(learning or memory)|go:"GO:0007614"(short-term memory)|go:"GO:0007616"(long-term memory)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010021"(amylopectin biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031550"(positive regulation of brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044381"(glucose import in response to insulin stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046323"(glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0098694"(regulation of synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0098793"(presynapse)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002441("Glucose transporter, type 4 (GLUT4)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-189200|ensembl:ENSRNOG00000017226(gene)|ensembl:ENSRNOT00000023256(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)	rgd:3415|refseq:NP_036766.1|interpro:IPR037515|reactome:R-RNO-73843|interpro:IPR029099|ensembl:ENSRNOT00000005615(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0002189"(ribose phosphate diphosphokinase complex)|go:"GO:0004749"(ribose phosphate diphosphokinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0006015"(5-phosphoribose 1-diphosphate biosynthetic process)|go:"GO:0006164"(purine nucleotide biosynthetic process)|go:"GO:0006167"(AMP biosynthetic process)|go:"GO:0009116"(nucleoside metabolic process)|go:"GO:0009165"(nucleotide biosynthetic process)|go:"GO:0016208"(AMP binding)|go:"GO:0016301"(kinase activity)|go:"GO:0019003"(GDP binding)|go:"GO:0019693"(ribose phosphate metabolic process)|go:"GO:0030246"(carbohydrate binding)|go:"GO:0031100"(animal organ regeneration)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043531"(ADP binding)|interpro:IPR000836(Phosphoribosyltransferase)|interpro:IPR000842(Phosphoribosyl pyrophosphate synthetase, conserved site)|interpro:IPR005946(Phosphoribosyl pyrophosphokinase)|interpro:IPR029057|ensembl:ENSRNOG00000004160(gene)	-	-	-	caution:"The participant EBI-349571(P68370) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919386(Q7TP47) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920972(Q5XIP9) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-916419(P11980) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919578(Q8R491) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920554(Q5U3Z7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920647(Q5U2X8) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920585(Q7TP24) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-779677(P05426) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-915744(P02454) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|agonist:Insulin was shown to increase or decrease GLUT4 protein interactions in specific cases.|comment:"Insulin decreased GLUT4 interactions with the following proteins: Q9ER30 (Sarcosin), P09527 (Rab-7), O88960 (N-ethylmaleimide sensitive), P09456 (PKA I regulatory subunit), P27881 (Hexokinase type II), P07872 (Acyl-coenzyme A oxidase), Q6DGF1 (Isocitrate dehydrogenase), Q9EQX9 (Ubiquitin-conjugating), Q63446 (Polyubiquitin), P24268 (Cathepsin D), Q91XW0 (Heat shock protein 86), Q5FVH0 (unknown), P58405 (Striatin 3), Q62667 (Major vault protein), Q66H50 (unknown), Q09167 (splicing factor), Q9JHU5 (Arfaptin 1)."|comment:"Insulin increased GLUT4 interaction with the following proteins:Q9Z1P2 (R-actinin-1), P45592 (Cofilin), Q9QXQ0 (R-actinin-4), P26473 (ADP-ribosylation factor), P26437 (ADP-ribosylation factor),   Q7TNP1 (Basigin 2), Q6P6R2 (Dihydrolipoamide dehydrogenase),   P04797 (GAPDH), Q63081 (Protein disulfide isomerase), P29457 (47 kDa heat shock protein), Q9R1J8 (Leprecan), O88638 (Putative eps protein),   Q64375 (Synaptonemal complex)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:NDPK - Interactions involving proteins containing InterPro domain IPR001564, Nucleoside diphosphate kinase, core.	taxid:10116(rat-l6)|taxid:10116(Rattus norvegicus)	-	2006/02/15	2021/11/30	rogid:PbFY2lfrty8yw40Jq7ShR7xfuV410116	rogid:1tzZjSk+0g5Axm74jOvtltjBXpM10116	intact-crc:44F3A2176D02515F|rigid:9RVm0UBcqQF4k06RGKO89Bg16Q8	false	myc tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P19357	uniprotkb:P08503	intact:EBI-915426|uniprotkb:P97900|ensembl:ENSRNOP00000023256	intact:EBI-916177	psi-mi:glut4_rat(display_long)|uniprotkb:Glucose transporter type 4, insulin-responsive(gene name synonym)|uniprotkb:Slc2a4(gene name)|psi-mi:Slc2a4(display_short)|uniprotkb:Glut4(gene name synonym)	psi-mi:acadm_rat(display_long)|uniprotkb:Acadm(gene name)|psi-mi:Acadm(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Foster et al. (2006)	pubmed:16396496|mint:MINT-5218203	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-921030	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2711|refseq:NP_036883.1|refseq:XP_006246658.1|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007611"(learning or memory)|go:"GO:0007614"(short-term memory)|go:"GO:0007616"(long-term memory)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010021"(amylopectin biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031550"(positive regulation of brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044381"(glucose import in response to insulin stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046323"(glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0098694"(regulation of synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0098793"(presynapse)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002441("Glucose transporter, type 4 (GLUT4)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-189200|ensembl:ENSRNOG00000017226(gene)|ensembl:ENSRNOT00000023256(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)	rgd:2012|refseq:NP_058682.2|interpro:IPR006089(Acyl-CoA dehydrogenase, conserved site)|interpro:IPR006091(Acyl-CoA dehydrogenase/oxidase, central region)|interpro:IPR009075(Acyl-CoA dehydrogenase/oxidase C-terminal)|interpro:IPR013786(Acyl-CoA dehydrogenase/oxidase, N-terminal)|interpro:IPR009100(Acyl-CoA dehydrogenase/oxidase, middle and N-terminal)|go:"GO:0000062"(fatty-acyl-CoA binding)|go:"GO:0001889"(liver development)|go:"GO:0003995"(acyl-CoA dehydrogenase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005978"(glycogen biosynthetic process)|go:"GO:0006082"(organic acid metabolic process)|go:"GO:0006111"(regulation of gluconeogenesis)|go:"GO:0006635"(fatty acid beta-oxidation)|go:"GO:0007507"(heart development)|go:"GO:0007584"(response to nutrient)|go:"GO:0009409"(response to cold)|go:"GO:0009437"(carnitine metabolic process)|go:"GO:0009725"(response to hormone)|go:"GO:0009791"(post-embryonic development)|go:"GO:0016853"(isomerase activity)|go:"GO:0019254"(carnitine metabolic process, CoA-linked)|go:"GO:0030424"(axon)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0033539"(fatty acid beta-oxidation using acyl-CoA dehydrogenase)|go:"GO:0042493"|go:"GO:0042594"(response to starvation)|go:"GO:0042802"(identical protein binding)|go:"GO:0045329"(carnitine biosynthetic process)|go:"GO:0046688"(response to copper ion)|go:"GO:0050660"(flavin adenine dinucleotide binding)|go:"GO:0051384"(response to glucocorticoid)|go:"GO:0051791"(medium-chain fatty acid metabolic process)|go:"GO:0051793"(medium-chain fatty acid catabolic process)|go:"GO:0055007"(cardiac muscle cell differentiation)|go:"GO:0070991"(medium-chain-acyl-CoA dehydrogenase activity)|interpro:IPR034180|interpro:IPR036250|interpro:IPR037069|reactome:R-RNO-77348|reactome:R-RNO-77288|reactome:R-RNO-77346	-	-	-	caution:"The participant EBI-349571(P68370) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919386(Q7TP47) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920972(Q5XIP9) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-916419(P11980) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919578(Q8R491) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920554(Q5U3Z7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920647(Q5U2X8) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920585(Q7TP24) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-779677(P05426) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-915744(P02454) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|agonist:Insulin was shown to increase or decrease GLUT4 protein interactions in specific cases.|comment:"Insulin decreased GLUT4 interactions with the following proteins: Q9ER30 (Sarcosin), P09527 (Rab-7), O88960 (N-ethylmaleimide sensitive), P09456 (PKA I regulatory subunit), P27881 (Hexokinase type II), P07872 (Acyl-coenzyme A oxidase), Q6DGF1 (Isocitrate dehydrogenase), Q9EQX9 (Ubiquitin-conjugating), Q63446 (Polyubiquitin), P24268 (Cathepsin D), Q91XW0 (Heat shock protein 86), Q5FVH0 (unknown), P58405 (Striatin 3), Q62667 (Major vault protein), Q66H50 (unknown), Q09167 (splicing factor), Q9JHU5 (Arfaptin 1)."|comment:"Insulin increased GLUT4 interaction with the following proteins:Q9Z1P2 (R-actinin-1), P45592 (Cofilin), Q9QXQ0 (R-actinin-4), P26473 (ADP-ribosylation factor), P26437 (ADP-ribosylation factor),   Q7TNP1 (Basigin 2), Q6P6R2 (Dihydrolipoamide dehydrogenase),   P04797 (GAPDH), Q63081 (Protein disulfide isomerase), P29457 (47 kDa heat shock protein), Q9R1J8 (Leprecan), O88638 (Putative eps protein),   Q64375 (Synaptonemal complex)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:NDPK - Interactions involving proteins containing InterPro domain IPR001564, Nucleoside diphosphate kinase, core.	taxid:10116(rat-l6)|taxid:10116(Rattus norvegicus)	-	2006/02/15	2021/11/30	rogid:PbFY2lfrty8yw40Jq7ShR7xfuV410116	rogid:QzB/XMZPqk7/4D8s8NXz0dWTgcU10116	intact-crc:44F3A2176D02515F|rigid:9RVm0UBcqQF4k06RGKO89Bg16Q8	false	myc tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P19357	uniprotkb:P08461	intact:EBI-915426|uniprotkb:P97900|ensembl:ENSRNOP00000023256	intact:EBI-916164|uniprotkb:Q3B7V7|ensembl:ENSRNOP00000032890	psi-mi:glut4_rat(display_long)|uniprotkb:Glucose transporter type 4, insulin-responsive(gene name synonym)|uniprotkb:Slc2a4(gene name)|psi-mi:Slc2a4(display_short)|uniprotkb:Glut4(gene name synonym)	psi-mi:odp2_rat(display_long)|uniprotkb:Dlat(gene name)|psi-mi:Dlat(display_short)|uniprotkb:Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex(gene name synonym)|uniprotkb:Pyruvate dehydrogenase complex component E2(gene name synonym)|uniprotkb:70 kDa mitochondrial autoantigen of primary biliary cirrhosis(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Foster et al. (2006)	pubmed:16396496|mint:MINT-5218203	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-921030	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2711|refseq:NP_036883.1|refseq:XP_006246658.1|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007611"(learning or memory)|go:"GO:0007614"(short-term memory)|go:"GO:0007616"(long-term memory)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010021"(amylopectin biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031550"(positive regulation of brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044381"(glucose import in response to insulin stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046323"(glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0098694"(regulation of synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0098793"(presynapse)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002441("Glucose transporter, type 4 (GLUT4)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-189200|ensembl:ENSRNOG00000017226(gene)|ensembl:ENSRNOT00000023256(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)	rgd:619859|refseq:NP_112287.1|reactome:R-RNO-204174|reactome:R-RNO-389661|reactome:R-RNO-5362517|reactome:R-RNO-70268|mint:P08461|ensembl:ENSRNOG00000009994(gene)|ensembl:ENSRNOT00000032152(transcript)|go:"GO:0000166"(nucleotide binding)|go:"GO:0004742"(dihydrolipoyllysine-residue acetyltransferase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0005967"(mitochondrial pyruvate dehydrogenase complex)|go:"GO:0006006"(glucose metabolic process)|go:"GO:0006086"(acetyl-CoA biosynthetic process from pyruvate)|go:"GO:0006099"(tricarboxylic acid cycle)|go:"GO:0030431"(sleep)|go:"GO:0034604"("pyruvate dehydrogenase (NAD+) activity")|go:"GO:0042802"(identical protein binding)|go:"GO:0045254"(pyruvate dehydrogenase complex)|interpro:IPR000089(Biotin/lipoyl attachment)|interpro:IPR001078(Catalytic domain of components of various dehydrogenase complexes)|interpro:IPR003016(2-oxo acid dehydrogenase, lipoyl-binding site)|interpro:IPR004167(E3 binding)|interpro:IPR006257(Dihydrolipoamide acetyltransferase, long form)|interpro:IPR011053(Single hybrid motif)|interpro:IPR023213|interpro:IPR036625	-	-	-	caution:"The participant EBI-349571(P68370) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919386(Q7TP47) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920972(Q5XIP9) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-916419(P11980) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919578(Q8R491) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920554(Q5U3Z7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920647(Q5U2X8) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920585(Q7TP24) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-779677(P05426) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-915744(P02454) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|agonist:Insulin was shown to increase or decrease GLUT4 protein interactions in specific cases.|comment:"Insulin decreased GLUT4 interactions with the following proteins: Q9ER30 (Sarcosin), P09527 (Rab-7), O88960 (N-ethylmaleimide sensitive), P09456 (PKA I regulatory subunit), P27881 (Hexokinase type II), P07872 (Acyl-coenzyme A oxidase), Q6DGF1 (Isocitrate dehydrogenase), Q9EQX9 (Ubiquitin-conjugating), Q63446 (Polyubiquitin), P24268 (Cathepsin D), Q91XW0 (Heat shock protein 86), Q5FVH0 (unknown), P58405 (Striatin 3), Q62667 (Major vault protein), Q66H50 (unknown), Q09167 (splicing factor), Q9JHU5 (Arfaptin 1)."|comment:"Insulin increased GLUT4 interaction with the following proteins:Q9Z1P2 (R-actinin-1), P45592 (Cofilin), Q9QXQ0 (R-actinin-4), P26473 (ADP-ribosylation factor), P26437 (ADP-ribosylation factor),   Q7TNP1 (Basigin 2), Q6P6R2 (Dihydrolipoamide dehydrogenase),   P04797 (GAPDH), Q63081 (Protein disulfide isomerase), P29457 (47 kDa heat shock protein), Q9R1J8 (Leprecan), O88638 (Putative eps protein),   Q64375 (Synaptonemal complex)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:NDPK - Interactions involving proteins containing InterPro domain IPR001564, Nucleoside diphosphate kinase, core.	taxid:10116(rat-l6)|taxid:10116(Rattus norvegicus)	-	2006/02/15	2021/11/30	rogid:PbFY2lfrty8yw40Jq7ShR7xfuV410116	rogid:XRVK9EEakONyvrLsZOP+1XhAfHA10116	intact-crc:44F3A2176D02515F|rigid:9RVm0UBcqQF4k06RGKO89Bg16Q8	false	myc tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P19357	uniprotkb:P08413	intact:EBI-915426|uniprotkb:P97900|ensembl:ENSRNOP00000023256	intact:EBI-916155	psi-mi:glut4_rat(display_long)|uniprotkb:Glucose transporter type 4, insulin-responsive(gene name synonym)|uniprotkb:Slc2a4(gene name)|psi-mi:Slc2a4(display_short)|uniprotkb:Glut4(gene name synonym)	psi-mi:kcc2b_rat(display_long)|uniprotkb:Camk2b(gene name)|psi-mi:Camk2b(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Foster et al. (2006)	pubmed:16396496|mint:MINT-5218203	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-921030	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2711|refseq:NP_036883.1|refseq:XP_006246658.1|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007611"(learning or memory)|go:"GO:0007614"(short-term memory)|go:"GO:0007616"(long-term memory)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010021"(amylopectin biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031550"(positive regulation of brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044381"(glucose import in response to insulin stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046323"(glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0098694"(regulation of synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0098793"(presynapse)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002441("Glucose transporter, type 4 (GLUT4)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-189200|ensembl:ENSRNOG00000017226(gene)|ensembl:ENSRNOT00000023256(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)	rgd:2262|refseq:NP_001035815.1|refseq:NP_068507.2|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0002030"(inhibitory G protein-coupled receptor phosphorylation)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004683"(calmodulin-dependent protein kinase activity)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0005829"(cytosol)|go:"GO:0005954"(calcium- and calmodulin-dependent protein kinase complex)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:0110088"(hippocampal neuron apoptotic process)|go:"GO:0006816"(calcium ion transport)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030425"(dendrite)|go:"GO:0032222"(regulation of synaptic transmission, cholinergic)|go:"GO:0032430"(positive regulation of phospholipase A2 activity)|go:"GO:0033017"(sarcoplasmic reticulum membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043005"(neuron projection)|go:"GO:0043204"(perikaryon)|go:"GO:0043274"(phospholipase binding)|go:"GO:0046686"(response to cadmium ion)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0048858"(cell projection morphogenesis)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0051233"(spindle midzone)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0060466"(activation of meiosis involved in egg activation)|go:"GO:0061003"(positive regulation of dendritic spine morphogenesis)|go:"GO:0090129"(positive regulation of synapse maturation)|go:"GO:0098973"(structural constituent of postsynaptic actin cytoskeleton)|reactome:R-RNO-5578775|reactome:R-RNO-5673000|reactome:R-RNO-5673001|reactome:R-RNO-877300|reactome:R-RNO-936837|mint:P08413|go:"GO:1903076"(regulation of protein localization to plasma membrane)|go:"GO:1905375"(cellular response to homocysteine)|go:"GO:1990911"(response to psychosocial stress)|go:"GO:2001222"(regulation of neuron migration)|go:"GO:2001235"(positive regulation of apoptotic signaling pathway)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR013543(Calcium/calmodulin dependent protein kinase II, association-domain)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR032710|rcsb pdb:6HCS|reactome:R-RNO-3371571|reactome:R-RNO-399719|reactome:R-RNO-438066|reactome:R-RNO-5576892|dip:DIP-36948N	-	-	-	caution:"The participant EBI-349571(P68370) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919386(Q7TP47) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920972(Q5XIP9) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-916419(P11980) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919578(Q8R491) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920554(Q5U3Z7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920647(Q5U2X8) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920585(Q7TP24) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-779677(P05426) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-915744(P02454) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|agonist:Insulin was shown to increase or decrease GLUT4 protein interactions in specific cases.|comment:"Insulin decreased GLUT4 interactions with the following proteins: Q9ER30 (Sarcosin), P09527 (Rab-7), O88960 (N-ethylmaleimide sensitive), P09456 (PKA I regulatory subunit), P27881 (Hexokinase type II), P07872 (Acyl-coenzyme A oxidase), Q6DGF1 (Isocitrate dehydrogenase), Q9EQX9 (Ubiquitin-conjugating), Q63446 (Polyubiquitin), P24268 (Cathepsin D), Q91XW0 (Heat shock protein 86), Q5FVH0 (unknown), P58405 (Striatin 3), Q62667 (Major vault protein), Q66H50 (unknown), Q09167 (splicing factor), Q9JHU5 (Arfaptin 1)."|comment:"Insulin increased GLUT4 interaction with the following proteins:Q9Z1P2 (R-actinin-1), P45592 (Cofilin), Q9QXQ0 (R-actinin-4), P26473 (ADP-ribosylation factor), P26437 (ADP-ribosylation factor),   Q7TNP1 (Basigin 2), Q6P6R2 (Dihydrolipoamide dehydrogenase),   P04797 (GAPDH), Q63081 (Protein disulfide isomerase), P29457 (47 kDa heat shock protein), Q9R1J8 (Leprecan), O88638 (Putative eps protein),   Q64375 (Synaptonemal complex)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:NDPK - Interactions involving proteins containing InterPro domain IPR001564, Nucleoside diphosphate kinase, core.	taxid:10116(rat-l6)|taxid:10116(Rattus norvegicus)	-	2006/02/15	2021/11/30	rogid:PbFY2lfrty8yw40Jq7ShR7xfuV410116	rogid:RojSx9Ro3RlYG4LM8c8FroRaKzs10116	intact-crc:44F3A2176D02515F|rigid:9RVm0UBcqQF4k06RGKO89Bg16Q8	false	myc tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P19357	uniprotkb:P63018	intact:EBI-915426|uniprotkb:P97900|ensembl:ENSRNOP00000023256	intact:EBI-433431|uniprotkb:P08109|uniprotkb:P12225|uniprotkb:Q4FZY7|uniprotkb:Q62373|uniprotkb:Q62374|uniprotkb:Q62375	psi-mi:glut4_rat(display_long)|uniprotkb:Glucose transporter type 4, insulin-responsive(gene name synonym)|uniprotkb:Slc2a4(gene name)|psi-mi:Slc2a4(display_short)|uniprotkb:Glut4(gene name synonym)	psi-mi:hsp7c_rat(display_long)|uniprotkb:Hspa8(gene name)|psi-mi:Hspa8(display_short)|uniprotkb:Hsc70(gene name synonym)|uniprotkb:Heat shock 70 kDa protein 8(gene name synonym)|uniprotkb:Hsc73(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Foster et al. (2006)	pubmed:16396496|mint:MINT-5218203	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-921030	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2711|refseq:NP_036883.1|refseq:XP_006246658.1|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007611"(learning or memory)|go:"GO:0007614"(short-term memory)|go:"GO:0007616"(long-term memory)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010021"(amylopectin biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031550"(positive regulation of brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044381"(glucose import in response to insulin stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046323"(glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0098694"(regulation of synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0098793"(presynapse)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002441("Glucose transporter, type 4 (GLUT4)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-189200|ensembl:ENSRNOG00000017226(gene)|ensembl:ENSRNOT00000023256(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)	rgd:621725|refseq:NP_077327.1|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0000974"(Prp19 complex)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0001786"(phosphatidylserine binding)|go:"GO:0001822"(kidney development)|go:"GO:0001916"(positive regulation of T cell mediated cytotoxicity)|go:"GO:0001917"(photoreceptor inner segment)|go:"GO:0003723"(RNA binding)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005681"(spliceosomal complex)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005770"(late endosome)|go:"GO:0005776"(autophagosome)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0005882"(intermediate filament)|go:"GO:0005886"(plasma membrane)|go:"GO:0006397"(mRNA processing)|go:"GO:0006457"(protein folding)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0007519"(skeletal muscle tissue development)|go:"GO:0007568"(aging)|go:"GO:0007608"(sensory perception of smell)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008088"(axo-dendritic transport)|go:"GO:0008380"(RNA splicing)|go:"GO:0009408"(response to heat)|go:"GO:0009986"(cell surface)|go:"GO:0010045"(response to nickel cation)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010667"(negative regulation of cardiac muscle cell apoptotic process)|go:"GO:0014069"(postsynaptic density)|go:"GO:0014823"(response to activity)|go:"GO:0016191"(synaptic vesicle uncoating)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0019899"(enzyme binding)|go:"GO:0021549"(cerebellum development)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0030900"(forebrain development)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0031686"(A1 adenosine receptor binding)|go:"GO:0032279"(asymmetric synapse)|go:"GO:0032355"(response to estradiol)|go:"GO:0032570"(response to progesterone)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034605"(cellular response to heat)|go:"GO:0034620"(cellular response to unfolded protein)|go:"GO:0042026"(protein refolding)|go:"GO:0042277"(peptide binding)|go:"GO:0042470"(melanosome)|go:"GO:0042493"|go:"GO:0042594"(response to starvation)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043085"(positive regulation of catalytic activity)|go:"GO:0043195"(terminal bouton)|go:"GO:0043197"(dendritic spine)|go:"GO:0043198"(dendritic shaft)|go:"GO:0043202"(lysosomal lumen)|go:"GO:0043204"(perikaryon)|go:"GO:0043531"(ADP binding)|go:"GO:0043624"|go:"GO:0044183"(protein folding chaperone)|go:"GO:0044309"(neuron spine)|go:"GO:0044743"(protein transmembrane import into intracellular organelle)|go:"GO:0044788"(modulation by host of viral process)|go:"GO:0044829"(positive regulation by host of viral genome replication)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0045862"(positive regulation of proteolysis)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0046034"(ATP metabolic process)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048026"(positive regulation of mRNA splicing, via spliceosome)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050766"(positive regulation of phagocytosis)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051085"(chaperone cofactor-dependent protein refolding)|go:"GO:0051087"(chaperone binding)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051787"(misfolded protein binding)|go:"GO:0055131"(C3HC4-type RING finger domain binding)|go:"GO:0061077"(chaperone-mediated protein folding)|go:"GO:0061635"(regulation of protein complex stability)|go:"GO:0061684"(chaperone-mediated autophagy)|go:"GO:0061738"(late endosomal microautophagy)|go:"GO:0061740"(protein targeting to lysosome involved in chaperone-mediated autophagy)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071276"(cellular response to cadmium ion)|go:"GO:0072318"(clathrin coat disassembly)|go:"GO:0097214"(positive regulation of lysosomal membrane permeability)|go:"GO:0044849"(estrous cycle)|go:"GO:0098684"(photoreceptor ribbon synapse)|go:"GO:0098690"(glycinergic synapse)|go:"GO:0098793"(presynapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098880"(maintenance of postsynaptic specialization structure)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099175"(regulation of postsynapse organization)|go:"GO:0099523"(presynaptic cytosol)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:0099634"(postsynaptic specialization membrane)|go:"GO:0101031"(chaperone complex)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1902904"(negative regulation of supramolecular fiber organization)|go:"GO:1903206"(negative regulation of hydrogen peroxide-induced cell death)|go:"GO:1904592"(positive regulation of protein refolding)|go:"GO:1904593"(prostaglandin binding)|go:"GO:1904764"(chaperone-mediated autophagy translocation complex disassembly)|go:"GO:1990124"(messenger ribonucleoprotein complex)|go:"GO:1990832"(slow axonal transport)|go:"GO:1990833"(clathrin-uncoating ATPase activity)|go:"GO:1990834"(response to odorant)|go:"GO:1990836"(lysosomal matrix)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR013126(Heat shock protein 70)|interpro:IPR018181|interpro:IPR029047|interpro:IPR029048|interpro:IPR043129|rcsb pdb:1CKR|rcsb pdb:1Q2G|rcsb pdb:1UD0|rcsb pdb:2V7Z|rcsb pdb:7HSC|mint:P63018|dip:DIP-33262N	-	-	-	caution:"The participant EBI-349571(P68370) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919386(Q7TP47) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920972(Q5XIP9) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-916419(P11980) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919578(Q8R491) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920554(Q5U3Z7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920647(Q5U2X8) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920585(Q7TP24) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-779677(P05426) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-915744(P02454) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|agonist:Insulin was shown to increase or decrease GLUT4 protein interactions in specific cases.|comment:"Insulin decreased GLUT4 interactions with the following proteins: Q9ER30 (Sarcosin), P09527 (Rab-7), O88960 (N-ethylmaleimide sensitive), P09456 (PKA I regulatory subunit), P27881 (Hexokinase type II), P07872 (Acyl-coenzyme A oxidase), Q6DGF1 (Isocitrate dehydrogenase), Q9EQX9 (Ubiquitin-conjugating), Q63446 (Polyubiquitin), P24268 (Cathepsin D), Q91XW0 (Heat shock protein 86), Q5FVH0 (unknown), P58405 (Striatin 3), Q62667 (Major vault protein), Q66H50 (unknown), Q09167 (splicing factor), Q9JHU5 (Arfaptin 1)."|comment:"Insulin increased GLUT4 interaction with the following proteins:Q9Z1P2 (R-actinin-1), P45592 (Cofilin), Q9QXQ0 (R-actinin-4), P26473 (ADP-ribosylation factor), P26437 (ADP-ribosylation factor),   Q7TNP1 (Basigin 2), Q6P6R2 (Dihydrolipoamide dehydrogenase),   P04797 (GAPDH), Q63081 (Protein disulfide isomerase), P29457 (47 kDa heat shock protein), Q9R1J8 (Leprecan), O88638 (Putative eps protein),   Q64375 (Synaptonemal complex)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:NDPK - Interactions involving proteins containing InterPro domain IPR001564, Nucleoside diphosphate kinase, core.	taxid:10116(rat-l6)|taxid:10116(Rattus norvegicus)	-	2006/02/15	2021/11/30	rogid:PbFY2lfrty8yw40Jq7ShR7xfuV410116	rogid:WDnUczLfoe3ODQbiEITN3DfQnFA10116	intact-crc:44F3A2176D02515F|rigid:9RVm0UBcqQF4k06RGKO89Bg16Q8	false	myc tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P19357	uniprotkb:P08081	intact:EBI-915426|uniprotkb:P97900|ensembl:ENSRNOP00000023256	intact:EBI-916140|ensembl:ENSRNOP00000019737	psi-mi:glut4_rat(display_long)|uniprotkb:Glucose transporter type 4, insulin-responsive(gene name synonym)|uniprotkb:Slc2a4(gene name)|psi-mi:Slc2a4(display_short)|uniprotkb:Glut4(gene name synonym)	psi-mi:clca_rat(display_long)|uniprotkb:Clta(gene name)|psi-mi:Clta(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Foster et al. (2006)	pubmed:16396496|mint:MINT-5218203	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-921030	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2711|refseq:NP_036883.1|refseq:XP_006246658.1|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007611"(learning or memory)|go:"GO:0007614"(short-term memory)|go:"GO:0007616"(long-term memory)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010021"(amylopectin biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031550"(positive regulation of brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044381"(glucose import in response to insulin stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046323"(glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0098694"(regulation of synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0098793"(presynapse)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002441("Glucose transporter, type 4 (GLUT4)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-189200|ensembl:ENSRNOG00000017226(gene)|ensembl:ENSRNOT00000023256(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)	ensembl:ENSRNOG00000014635(gene)|ensembl:ENSRNOT00000019737(transcript)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005819"(spindle)|go:"GO:0005886"(plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006897"(endocytosis)|go:"GO:0007049"(cell cycle)|go:"GO:0030118"(clathrin coat)|go:"GO:0030125"(clathrin vesicle coat)|go:"GO:0030130"(clathrin coat of trans-Golgi network vesicle)|go:"GO:0030132"(clathrin coat of coated pit)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030669"(clathrin-coated endocytic vesicle membrane)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0032050"(clathrin heavy chain binding)|go:"GO:0042277"(peptide binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0048268"(clathrin coat assembly)|go:"GO:0051020"(GTPase binding)|go:"GO:0051301"(cell division)|go:"GO:0071439"(clathrin complex)|go:"GO:0072583"(clathrin-dependent endocytosis)|go:"GO:0098835"(presynaptic endocytic zone membrane)|go:"GO:0098843"(postsynaptic endocytic zone)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099631"(postsynaptic endocytic zone cytoplasmic component)|interpro:IPR000996(Clathrin light chain)|mint:P08081|reactome:R-RNO-177504|reactome:R-RNO-190873|reactome:R-RNO-196025|reactome:R-RNO-2132295|reactome:R-RNO-432720|reactome:R-RNO-432722|reactome:R-RNO-437239|reactome:R-RNO-5099900|reactome:R-RNO-5140745|reactome:R-RNO-8856825|reactome:R-RNO-8856828|reactome:R-RNO-8866427|reactome:R-RNO-8964038|rgd:70919|refseq:NP_114180.1|refseq:XP_006238166.1|refseq:XP_006238168.1|dip:DIP-36947N	-	-	-	caution:"The participant EBI-349571(P68370) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919386(Q7TP47) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920972(Q5XIP9) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-916419(P11980) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919578(Q8R491) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920554(Q5U3Z7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920647(Q5U2X8) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920585(Q7TP24) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-779677(P05426) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-915744(P02454) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|agonist:Insulin was shown to increase or decrease GLUT4 protein interactions in specific cases.|comment:"Insulin decreased GLUT4 interactions with the following proteins: Q9ER30 (Sarcosin), P09527 (Rab-7), O88960 (N-ethylmaleimide sensitive), P09456 (PKA I regulatory subunit), P27881 (Hexokinase type II), P07872 (Acyl-coenzyme A oxidase), Q6DGF1 (Isocitrate dehydrogenase), Q9EQX9 (Ubiquitin-conjugating), Q63446 (Polyubiquitin), P24268 (Cathepsin D), Q91XW0 (Heat shock protein 86), Q5FVH0 (unknown), P58405 (Striatin 3), Q62667 (Major vault protein), Q66H50 (unknown), Q09167 (splicing factor), Q9JHU5 (Arfaptin 1)."|comment:"Insulin increased GLUT4 interaction with the following proteins:Q9Z1P2 (R-actinin-1), P45592 (Cofilin), Q9QXQ0 (R-actinin-4), P26473 (ADP-ribosylation factor), P26437 (ADP-ribosylation factor),   Q7TNP1 (Basigin 2), Q6P6R2 (Dihydrolipoamide dehydrogenase),   P04797 (GAPDH), Q63081 (Protein disulfide isomerase), P29457 (47 kDa heat shock protein), Q9R1J8 (Leprecan), O88638 (Putative eps protein),   Q64375 (Synaptonemal complex)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:NDPK - Interactions involving proteins containing InterPro domain IPR001564, Nucleoside diphosphate kinase, core.	taxid:10116(rat-l6)|taxid:10116(Rattus norvegicus)	-	2006/02/15	2021/11/30	rogid:PbFY2lfrty8yw40Jq7ShR7xfuV410116	rogid:josnOtPnIhM+WCMg+3/jsbSvdec10116	intact-crc:44F3A2176D02515F|rigid:9RVm0UBcqQF4k06RGKO89Bg16Q8	false	myc tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P19357	uniprotkb:P08010	intact:EBI-915426|uniprotkb:P97900|ensembl:ENSRNOP00000023256	intact:EBI-916128|ensembl:ENSRNOP00000025939	psi-mi:glut4_rat(display_long)|uniprotkb:Glucose transporter type 4, insulin-responsive(gene name synonym)|uniprotkb:Slc2a4(gene name)|psi-mi:Slc2a4(display_short)|uniprotkb:Glut4(gene name synonym)	psi-mi:gstm2_rat(display_long)|uniprotkb:Gstm2(gene name)|psi-mi:Gstm2(display_short)|uniprotkb:GSTM2-2(gene name synonym)|uniprotkb:Glutathione S-transferase Yb-2(gene name synonym)|uniprotkb:GST 4-4(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Foster et al. (2006)	pubmed:16396496|mint:MINT-5218203	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-921030	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2711|refseq:NP_036883.1|refseq:XP_006246658.1|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007611"(learning or memory)|go:"GO:0007614"(short-term memory)|go:"GO:0007616"(long-term memory)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010021"(amylopectin biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031550"(positive regulation of brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044381"(glucose import in response to insulin stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046323"(glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0098694"(regulation of synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0098793"(presynapse)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002441("Glucose transporter, type 4 (GLUT4)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-189200|ensembl:ENSRNOG00000017226(gene)|ensembl:ENSRNOT00000023256(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)	go:"GO:0018916"(nitrobenzene metabolic process)|go:"GO:0019899"(enzyme binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033595"(response to genistein)|go:"GO:0042178"(xenobiotic catabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043295"(glutathione binding)|go:"GO:0043651"(linoleic acid metabolic process)|go:"GO:0051122"(hepoxilin biosynthetic process)|go:"GO:0060315"(negative regulation of ryanodine-sensitive calcium-release channel activity)|go:"GO:0060316"(positive regulation of ryanodine-sensitive calcium-release channel activity)|go:"GO:0070458"(cellular detoxification of nitrogen compound)|go:"GO:0071313"(cellular response to caffeine)|go:"GO:1902168"(response to catechin)|interpro:IPR003081(Glutathione S-transferase, Mu class)|interpro:IPR004045(Glutathione S-transferase, N-terminal)|interpro:IPR004046(Glutathione S-transferase, C-terminal)|interpro:IPR010987(Glutathione S-transferase, C-terminal-like)|interpro:IPR036249|interpro:IPR036282|interpro:IPR040079|rcsb pdb:1B4P|reactome:R-RNO-156590|ensembl:ENSRNOG00000018937(gene)|ensembl:ENSRNOT00000025939(transcript)|go:"GO:0004364"(glutathione transferase activity)|go:"GO:0004602"(glutathione peroxidase activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005504"(fatty acid binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006749"(glutathione metabolic process)|go:"GO:0006805"(xenobiotic metabolic process)|go:"GO:0007568"(aging)|go:"GO:0007608"(sensory perception of smell)|go:"GO:0010038"(response to metal ion)|go:"GO:0010880"(regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum)|go:"GO:0014070"(response to organic cyclic compound)|go:"GO:0016529"(sarcoplasmic reticulum)|rgd:2756|refseq:NP_803175.1	-	-	-	caution:"The participant EBI-349571(P68370) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919386(Q7TP47) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920972(Q5XIP9) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-916419(P11980) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919578(Q8R491) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920554(Q5U3Z7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920647(Q5U2X8) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920585(Q7TP24) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-779677(P05426) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-915744(P02454) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|agonist:Insulin was shown to increase or decrease GLUT4 protein interactions in specific cases.|comment:"Insulin decreased GLUT4 interactions with the following proteins: Q9ER30 (Sarcosin), P09527 (Rab-7), O88960 (N-ethylmaleimide sensitive), P09456 (PKA I regulatory subunit), P27881 (Hexokinase type II), P07872 (Acyl-coenzyme A oxidase), Q6DGF1 (Isocitrate dehydrogenase), Q9EQX9 (Ubiquitin-conjugating), Q63446 (Polyubiquitin), P24268 (Cathepsin D), Q91XW0 (Heat shock protein 86), Q5FVH0 (unknown), P58405 (Striatin 3), Q62667 (Major vault protein), Q66H50 (unknown), Q09167 (splicing factor), Q9JHU5 (Arfaptin 1)."|comment:"Insulin increased GLUT4 interaction with the following proteins:Q9Z1P2 (R-actinin-1), P45592 (Cofilin), Q9QXQ0 (R-actinin-4), P26473 (ADP-ribosylation factor), P26437 (ADP-ribosylation factor),   Q7TNP1 (Basigin 2), Q6P6R2 (Dihydrolipoamide dehydrogenase),   P04797 (GAPDH), Q63081 (Protein disulfide isomerase), P29457 (47 kDa heat shock protein), Q9R1J8 (Leprecan), O88638 (Putative eps protein),   Q64375 (Synaptonemal complex)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:NDPK - Interactions involving proteins containing InterPro domain IPR001564, Nucleoside diphosphate kinase, core.	taxid:10116(rat-l6)|taxid:10116(Rattus norvegicus)	-	2006/02/15	2021/11/30	rogid:PbFY2lfrty8yw40Jq7ShR7xfuV410116	rogid:sJbLaPIaLFd6NRu/GPiI7fJnlFU10116	intact-crc:44F3A2176D02515F|rigid:9RVm0UBcqQF4k06RGKO89Bg16Q8	false	myc tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P19357	uniprotkb:P07895	intact:EBI-915426|uniprotkb:P97900|ensembl:ENSRNOP00000023256	intact:EBI-916117|ensembl:ENSRNOP00000025794	psi-mi:glut4_rat(display_long)|uniprotkb:Glucose transporter type 4, insulin-responsive(gene name synonym)|uniprotkb:Slc2a4(gene name)|psi-mi:Slc2a4(display_short)|uniprotkb:Glut4(gene name synonym)	psi-mi:sodm_rat(display_long)|uniprotkb:Sod2(gene name)|psi-mi:Sod2(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Foster et al. (2006)	pubmed:16396496|mint:MINT-5218203	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-921030	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2711|refseq:NP_036883.1|refseq:XP_006246658.1|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007611"(learning or memory)|go:"GO:0007614"(short-term memory)|go:"GO:0007616"(long-term memory)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010021"(amylopectin biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031550"(positive regulation of brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044381"(glucose import in response to insulin stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046323"(glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0098694"(regulation of synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0098793"(presynapse)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002441("Glucose transporter, type 4 (GLUT4)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-189200|ensembl:ENSRNOG00000017226(gene)|ensembl:ENSRNOT00000023256(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)	rgd:3732|refseq:NP_058747.1|go:"GO:0004784"(superoxide dismutase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006749"(glutathione metabolic process)|go:"GO:0006801"(superoxide metabolic process)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0007507"(heart development)|go:"GO:0007568"(aging)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008217"(regulation of blood pressure)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0008631"(intrinsic apoptotic signaling pathway in response to oxidative stress)|go:"GO:0008637"(apoptotic mitochondrial changes)|go:"GO:0009314"(response to radiation)|go:"GO:0009409"(response to cold)|go:"GO:0009791"(post-embryonic development)|go:"GO:0010042"(response to manganese ion)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010269"(response to selenium ion)|ensembl:ENSRNOG00000019048(gene)|ensembl:ENSRNOT00000025794(transcript)|go:"GO:0000302"(response to reactive oxygen species)|go:"GO:0000303"(response to superoxide)|go:"GO:0001306"(age-dependent response to oxidative stress)|go:"GO:0001315"(age-dependent response to reactive oxygen species)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001836"(release of cytochrome c from mitochondria)|go:"GO:0001889"(liver development)|go:"GO:0003032"(detection of oxygen)|go:"GO:0003069"(acetylcholine-mediated vasodilation involved in regulation of systemic arterial blood pressure)|go:"GO:0003677"(DNA binding)|go:"GO:0010332"(response to gamma radiation)|go:"GO:0010729"(positive regulation of hydrogen peroxide biosynthetic process)|go:"GO:0014823"(response to activity)|go:"GO:0016491"(oxidoreductase activity)|go:"GO:0019430"(removal of superoxide radicals)|go:"GO:0019825"(oxygen binding)|go:"GO:0019899"(enzyme binding)|go:"GO:0022904"(respiratory electron transport chain)|go:"GO:0030097"(hemopoiesis)|go:"GO:0030145"(manganese ion binding)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0031667"(response to nutrient levels)|go:"GO:0032364"(oxygen homeostasis)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0033591"(response to L-ascorbic acid)|go:"GO:0034021"(response to silicon dioxide)|go:"GO:0035900"(response to isolation stress)|go:"GO:0035902"(response to immobilization stress)|go:"GO:0042311"(vasodilation)|go:"GO:0042493"|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0042554"(superoxide anion generation)|go:"GO:0042645"(mitochondrial nucleoid)|go:"GO:0042743"(hydrogen peroxide metabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0045429"(positive regulation of nitric oxide biosynthetic process)|go:"GO:0045599"(negative regulation of fat cell differentiation)|go:"GO:0046686"(response to cadmium ion)|go:"GO:0048147"(negative regulation of fibroblast proliferation)|go:"GO:0048666"(neuron development)|go:"GO:0048678"(response to axon injury)|go:"GO:0048773"(erythrophore differentiation)|go:"GO:0050665"(hydrogen peroxide biosynthetic process)|go:"GO:0050790"(regulation of catalytic activity)|go:"GO:0051289"(protein homotetramerization)|go:"GO:0051602"(response to electrical stimulus)|go:"GO:0051881"(regulation of mitochondrial membrane potential)|go:"GO:0055072"(iron ion homeostasis)|go:"GO:0055093"(response to hyperoxia)|go:"GO:0071000"(response to magnetism)|go:"GO:0071361"(cellular response to ethanol)|go:"GO:1902176"(negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway)|go:"GO:1902631"(negative regulation of membrane hyperpolarization)|go:"GO:1904706"(negative regulation of vascular associated smooth muscle cell proliferation)|go:"GO:1905461"(positive regulation of vascular associated smooth muscle cell apoptotic process)|go:"GO:1905932"(positive regulation of vascular associated smooth muscle cell differentiation involved in phenotypic switching)|interpro:IPR001189(Manganese and iron superoxide dismutase)|interpro:IPR019831|interpro:IPR019832|interpro:IPR019833|interpro:IPR036314|interpro:IPR036324|reactome:R-RNO-2151201|reactome:R-RNO-3299685	-	-	-	caution:"The participant EBI-349571(P68370) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919386(Q7TP47) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920972(Q5XIP9) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-916419(P11980) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919578(Q8R491) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920554(Q5U3Z7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920647(Q5U2X8) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920585(Q7TP24) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-779677(P05426) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-915744(P02454) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|agonist:Insulin was shown to increase or decrease GLUT4 protein interactions in specific cases.|comment:"Insulin decreased GLUT4 interactions with the following proteins: Q9ER30 (Sarcosin), P09527 (Rab-7), O88960 (N-ethylmaleimide sensitive), P09456 (PKA I regulatory subunit), P27881 (Hexokinase type II), P07872 (Acyl-coenzyme A oxidase), Q6DGF1 (Isocitrate dehydrogenase), Q9EQX9 (Ubiquitin-conjugating), Q63446 (Polyubiquitin), P24268 (Cathepsin D), Q91XW0 (Heat shock protein 86), Q5FVH0 (unknown), P58405 (Striatin 3), Q62667 (Major vault protein), Q66H50 (unknown), Q09167 (splicing factor), Q9JHU5 (Arfaptin 1)."|comment:"Insulin increased GLUT4 interaction with the following proteins:Q9Z1P2 (R-actinin-1), P45592 (Cofilin), Q9QXQ0 (R-actinin-4), P26473 (ADP-ribosylation factor), P26437 (ADP-ribosylation factor),   Q7TNP1 (Basigin 2), Q6P6R2 (Dihydrolipoamide dehydrogenase),   P04797 (GAPDH), Q63081 (Protein disulfide isomerase), P29457 (47 kDa heat shock protein), Q9R1J8 (Leprecan), O88638 (Putative eps protein),   Q64375 (Synaptonemal complex)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:NDPK - Interactions involving proteins containing InterPro domain IPR001564, Nucleoside diphosphate kinase, core.	taxid:10116(rat-l6)|taxid:10116(Rattus norvegicus)	-	2006/02/15	2021/11/30	rogid:PbFY2lfrty8yw40Jq7ShR7xfuV410116	rogid:iaRkISri7gkswMDJXUVFZoUXocY10116	intact-crc:44F3A2176D02515F|rigid:9RVm0UBcqQF4k06RGKO89Bg16Q8	false	myc tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P19357	uniprotkb:P07872	intact:EBI-915426|uniprotkb:P97900|ensembl:ENSRNOP00000023256	intact:EBI-916098|uniprotkb:P11354	psi-mi:glut4_rat(display_long)|uniprotkb:Glucose transporter type 4, insulin-responsive(gene name synonym)|uniprotkb:Slc2a4(gene name)|psi-mi:Slc2a4(display_short)|uniprotkb:Glut4(gene name synonym)	psi-mi:acox1_rat(display_long)|uniprotkb:Acox1(gene name)|psi-mi:Acox1(display_short)|uniprotkb:Acox(gene name synonym)|uniprotkb:Palmitoyl-CoA oxidase(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Foster et al. (2006)	pubmed:16396496|mint:MINT-5218203	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-921030	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2711|refseq:NP_036883.1|refseq:XP_006246658.1|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007611"(learning or memory)|go:"GO:0007614"(short-term memory)|go:"GO:0007616"(long-term memory)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010021"(amylopectin biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031550"(positive regulation of brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044381"(glucose import in response to insulin stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046323"(glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0098694"(regulation of synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0098793"(presynapse)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002441("Glucose transporter, type 4 (GLUT4)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-189200|ensembl:ENSRNOG00000017226(gene)|ensembl:ENSRNOT00000023256(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)	interpro:IPR029320|rgd:619757|refseq:NP_059036.1|interpro:IPR006091(Acyl-CoA dehydrogenase/oxidase, central region)|go:"GO:0000038"(very long-chain fatty acid metabolic process)|go:"GO:0003997"(acyl-CoA oxidase activity)|go:"GO:0005504"(fatty acid binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005777"(peroxisome)|go:"GO:0005778"(peroxisomal membrane)|go:"GO:0005782"(peroxisomal matrix)|go:"GO:0006091"(generation of precursor metabolites and energy)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0006693"(prostaglandin metabolic process)|go:"GO:0007283"(spermatogenesis)|go:"GO:0009062"(fatty acid catabolic process)|go:"GO:0016401"(palmitoyl-CoA oxidase activity)|go:"GO:0019395"(fatty acid oxidation)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0033540"(fatty acid beta-oxidation using acyl-CoA oxidase)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0050660"(flavin adenine dinucleotide binding)|go:"GO:0050665"(hydrogen peroxide biosynthetic process)|go:"GO:0055088"(lipid homeostasis)|go:"GO:0071949"(FAD binding)|go:"GO:0140493"(very long-chain fatty acid beta-oxidation)|interpro:IPR012258(Acyl-CoA oxidase)|interpro:IPR002655(Acyl-CoA oxidase, C-terminal)|interpro:IPR009100(Acyl-CoA dehydrogenase/oxidase, middle and N-terminal)|rcsb pdb:1IS2|rcsb pdb:2DDH|interpro:IPR034171|interpro:IPR036250|interpro:IPR037069|reactome:R-RNO-390247|reactome:R-RNO-9033241|reactome:R-RNO-2046106	-	-	-	caution:"The participant EBI-349571(P68370) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919386(Q7TP47) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920972(Q5XIP9) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-916419(P11980) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919578(Q8R491) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920554(Q5U3Z7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920647(Q5U2X8) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920585(Q7TP24) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-779677(P05426) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-915744(P02454) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|agonist:Insulin was shown to increase or decrease GLUT4 protein interactions in specific cases.|comment:"Insulin decreased GLUT4 interactions with the following proteins: Q9ER30 (Sarcosin), P09527 (Rab-7), O88960 (N-ethylmaleimide sensitive), P09456 (PKA I regulatory subunit), P27881 (Hexokinase type II), P07872 (Acyl-coenzyme A oxidase), Q6DGF1 (Isocitrate dehydrogenase), Q9EQX9 (Ubiquitin-conjugating), Q63446 (Polyubiquitin), P24268 (Cathepsin D), Q91XW0 (Heat shock protein 86), Q5FVH0 (unknown), P58405 (Striatin 3), Q62667 (Major vault protein), Q66H50 (unknown), Q09167 (splicing factor), Q9JHU5 (Arfaptin 1)."|comment:"Insulin increased GLUT4 interaction with the following proteins:Q9Z1P2 (R-actinin-1), P45592 (Cofilin), Q9QXQ0 (R-actinin-4), P26473 (ADP-ribosylation factor), P26437 (ADP-ribosylation factor),   Q7TNP1 (Basigin 2), Q6P6R2 (Dihydrolipoamide dehydrogenase),   P04797 (GAPDH), Q63081 (Protein disulfide isomerase), P29457 (47 kDa heat shock protein), Q9R1J8 (Leprecan), O88638 (Putative eps protein),   Q64375 (Synaptonemal complex)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:NDPK - Interactions involving proteins containing InterPro domain IPR001564, Nucleoside diphosphate kinase, core.	taxid:10116(rat-l6)|taxid:10116(Rattus norvegicus)	-	2006/02/15	2021/11/30	rogid:PbFY2lfrty8yw40Jq7ShR7xfuV410116	rogid:cz0xQyb5Q7kLPAqVYeds3iytKGk10116	intact-crc:44F3A2176D02515F|rigid:9RVm0UBcqQF4k06RGKO89Bg16Q8	false	myc tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P19357	uniprotkb:P07871	intact:EBI-915426|uniprotkb:P97900|ensembl:ENSRNOP00000023256	intact:EBI-916093|uniprotkb:Q4G049	psi-mi:glut4_rat(display_long)|uniprotkb:Glucose transporter type 4, insulin-responsive(gene name synonym)|uniprotkb:Slc2a4(gene name)|psi-mi:Slc2a4(display_short)|uniprotkb:Glut4(gene name synonym)	psi-mi:thikb_rat(display_long)|uniprotkb:Acaa1b(gene name)|psi-mi:Acaa1b(display_short)|uniprotkb:Beta-ketothiolase B(gene name synonym)|uniprotkb:Acetyl-CoA acyltransferase B(gene name synonym)|uniprotkb:Peroxisomal 3-oxoacyl-CoA thiolase B(gene name synonym)|uniprotkb:Acaa1(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Foster et al. (2006)	pubmed:16396496|mint:MINT-5218203	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-921030	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2711|refseq:NP_036883.1|refseq:XP_006246658.1|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007611"(learning or memory)|go:"GO:0007614"(short-term memory)|go:"GO:0007616"(long-term memory)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010021"(amylopectin biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031550"(positive regulation of brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044381"(glucose import in response to insulin stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046323"(glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0098694"(regulation of synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0098793"(presynapse)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002441("Glucose transporter, type 4 (GLUT4)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-189200|ensembl:ENSRNOG00000017226(gene)|ensembl:ENSRNOT00000023256(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)	interpro:IPR020615|interpro:IPR020610|interpro:IPR020617|interpro:IPR020613|interpro:IPR020616|rgd:1562373|refseq:NP_001035108.1|interpro:IPR002155(Thiolase)|interpro:IPR016039(Thiolase-like)|go:"GO:0003985"(acetyl-CoA C-acetyltransferase activity)|go:"GO:0003988"(acetyl-CoA C-acyltransferase activity)|go:"GO:0005777"(peroxisome)|go:"GO:0006635"(fatty acid beta-oxidation)|go:"GO:0010124"(phenylacetate catabolic process)|go:"GO:0050633"(acetyl-CoA C-myristoyltransferase activity)	-	-	-	caution:"The participant EBI-349571(P68370) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919386(Q7TP47) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920972(Q5XIP9) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-916419(P11980) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919578(Q8R491) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920554(Q5U3Z7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920647(Q5U2X8) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920585(Q7TP24) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-779677(P05426) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-915744(P02454) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|agonist:Insulin was shown to increase or decrease GLUT4 protein interactions in specific cases.|comment:"Insulin decreased GLUT4 interactions with the following proteins: Q9ER30 (Sarcosin), P09527 (Rab-7), O88960 (N-ethylmaleimide sensitive), P09456 (PKA I regulatory subunit), P27881 (Hexokinase type II), P07872 (Acyl-coenzyme A oxidase), Q6DGF1 (Isocitrate dehydrogenase), Q9EQX9 (Ubiquitin-conjugating), Q63446 (Polyubiquitin), P24268 (Cathepsin D), Q91XW0 (Heat shock protein 86), Q5FVH0 (unknown), P58405 (Striatin 3), Q62667 (Major vault protein), Q66H50 (unknown), Q09167 (splicing factor), Q9JHU5 (Arfaptin 1)."|comment:"Insulin increased GLUT4 interaction with the following proteins:Q9Z1P2 (R-actinin-1), P45592 (Cofilin), Q9QXQ0 (R-actinin-4), P26473 (ADP-ribosylation factor), P26437 (ADP-ribosylation factor),   Q7TNP1 (Basigin 2), Q6P6R2 (Dihydrolipoamide dehydrogenase),   P04797 (GAPDH), Q63081 (Protein disulfide isomerase), P29457 (47 kDa heat shock protein), Q9R1J8 (Leprecan), O88638 (Putative eps protein),   Q64375 (Synaptonemal complex)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:NDPK - Interactions involving proteins containing InterPro domain IPR001564, Nucleoside diphosphate kinase, core.	taxid:10116(rat-l6)|taxid:10116(Rattus norvegicus)	-	2006/02/15	2021/11/30	rogid:PbFY2lfrty8yw40Jq7ShR7xfuV410116	rogid:k9w3gJhDvlN+1dUM4ZZecgPV2YY10116	intact-crc:44F3A2176D02515F|rigid:9RVm0UBcqQF4k06RGKO89Bg16Q8	false	myc tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P19357	uniprotkb:P07824	intact:EBI-915426|uniprotkb:P97900|ensembl:ENSRNOP00000023256	intact:EBI-916084|uniprotkb:Q5BK93|ensembl:ENSRNOP00000017911	psi-mi:glut4_rat(display_long)|uniprotkb:Glucose transporter type 4, insulin-responsive(gene name synonym)|uniprotkb:Slc2a4(gene name)|psi-mi:Slc2a4(display_short)|uniprotkb:Glut4(gene name synonym)	psi-mi:argi1_rat(display_long)|uniprotkb:Arg1(gene name)|psi-mi:Arg1(display_short)|uniprotkb:Type I arginase(gene name synonym)|uniprotkb:Liver-type arginase(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Foster et al. (2006)	pubmed:16396496|mint:MINT-5218203	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-921030	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2711|refseq:NP_036883.1|refseq:XP_006246658.1|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007611"(learning or memory)|go:"GO:0007614"(short-term memory)|go:"GO:0007616"(long-term memory)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010021"(amylopectin biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031550"(positive regulation of brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044381"(glucose import in response to insulin stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046323"(glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0098694"(regulation of synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0098793"(presynapse)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002441("Glucose transporter, type 4 (GLUT4)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-189200|ensembl:ENSRNOG00000017226(gene)|ensembl:ENSRNOT00000023256(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)	go:"GO:0043434"(response to peptide hormone)|go:"GO:0045087"(innate immune response)|go:"GO:0046007"(negative regulation of activated T cell proliferation)|go:"GO:0046686"(response to cadmium ion)|go:"GO:0048545"(response to steroid hormone)|go:"GO:0048678"(response to axon injury)|go:"GO:0051597"(response to methylmercury)|go:"GO:0060056"(mammary gland involution)|go:"GO:0060135"(maternal process involved in female pregnancy)|go:"GO:0060336"(negative regulation of interferon-gamma-mediated signaling pathway)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0070965"(positive regulation of neutrophil mediated killing of fungus)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071353"(cellular response to interleukin-4)|go:"GO:0071377"(cellular response to glucagon stimulus)|go:"GO:0071549"(cellular response to dexamethasone stimulus)|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|go:"GO:2000552"(negative regulation of T-helper 2 cell cytokine production)|interpro:IPR006035(Ureohydrolase)|interpro:IPR014033(Arginase, subgroup)|interpro:IPR020855|interpro:IPR023696|rcsb pdb:1D3V|rcsb pdb:1HQ5|rcsb pdb:1HQF|rcsb pdb:1HQG|rcsb pdb:1HQH|rcsb pdb:1HQX|rcsb pdb:1P8M|rcsb pdb:1P8N|rcsb pdb:1P8O|rcsb pdb:1P8P|rcsb pdb:1P8Q|rcsb pdb:1P8R|rcsb pdb:1P8S|rcsb pdb:1R1O|rcsb pdb:1RLA|rcsb pdb:1T4P|rcsb pdb:1T4R|rcsb pdb:1T4S|rcsb pdb:1T4T|rcsb pdb:1T5F|rcsb pdb:1T5G|rcsb pdb:1TA1|rcsb pdb:1TBH|rcsb pdb:1TBJ|rcsb pdb:1TBL|rcsb pdb:1ZPE|rcsb pdb:1ZPG|rcsb pdb:2RLA|rcsb pdb:3E8Q|rcsb pdb:3E8Z|rcsb pdb:3E9B|rcsb pdb:3RLA|rcsb pdb:4RLA|rcsb pdb:5RLA|reactome:R-RNO-6798695|reactome:R-RNO-70635|ensembl:ENSRNOG00000013304(gene)|ensembl:ENSRNOT00000017911(transcript)|go:"GO:0043200"(response to amino acid)|go:"GO:0000050"(urea cycle)|go:"GO:0001889"(liver development)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0002250"(adaptive immune response)|go:"GO:0004053"(arginase activity)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005829"(cytosol)|go:"GO:0006525"(arginine metabolic process)|go:"GO:0007565"(female pregnancy)|go:"GO:0007568"(aging)|go:"GO:0009611"(response to wounding)|go:"GO:0009635"(response to herbicide)|go:"GO:0010042"(response to manganese ion)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010269"(response to selenium ion)|go:"GO:0010963"|go:"GO:0014075"(response to amine)|go:"GO:0019547"(arginine catabolic process to ornithine)|go:"GO:0030145"(manganese ion binding)|go:"GO:0030324"(lung development)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032964"(collagen biosynthetic process)|go:"GO:0033189"(response to vitamin A)|go:"GO:0033197"(response to vitamin E)|go:"GO:0042130"(negative regulation of T cell proliferation)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0042832"(defense response to protozoan)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|rgd:2150|refseq:NP_058830.2	-	-	-	caution:"The participant EBI-349571(P68370) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919386(Q7TP47) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920972(Q5XIP9) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-916419(P11980) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919578(Q8R491) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920554(Q5U3Z7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920647(Q5U2X8) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920585(Q7TP24) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-779677(P05426) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-915744(P02454) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|agonist:Insulin was shown to increase or decrease GLUT4 protein interactions in specific cases.|comment:"Insulin decreased GLUT4 interactions with the following proteins: Q9ER30 (Sarcosin), P09527 (Rab-7), O88960 (N-ethylmaleimide sensitive), P09456 (PKA I regulatory subunit), P27881 (Hexokinase type II), P07872 (Acyl-coenzyme A oxidase), Q6DGF1 (Isocitrate dehydrogenase), Q9EQX9 (Ubiquitin-conjugating), Q63446 (Polyubiquitin), P24268 (Cathepsin D), Q91XW0 (Heat shock protein 86), Q5FVH0 (unknown), P58405 (Striatin 3), Q62667 (Major vault protein), Q66H50 (unknown), Q09167 (splicing factor), Q9JHU5 (Arfaptin 1)."|comment:"Insulin increased GLUT4 interaction with the following proteins:Q9Z1P2 (R-actinin-1), P45592 (Cofilin), Q9QXQ0 (R-actinin-4), P26473 (ADP-ribosylation factor), P26437 (ADP-ribosylation factor),   Q7TNP1 (Basigin 2), Q6P6R2 (Dihydrolipoamide dehydrogenase),   P04797 (GAPDH), Q63081 (Protein disulfide isomerase), P29457 (47 kDa heat shock protein), Q9R1J8 (Leprecan), O88638 (Putative eps protein),   Q64375 (Synaptonemal complex)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:NDPK - Interactions involving proteins containing InterPro domain IPR001564, Nucleoside diphosphate kinase, core.	taxid:10116(rat-l6)|taxid:10116(Rattus norvegicus)	-	2006/02/15	2021/11/30	rogid:PbFY2lfrty8yw40Jq7ShR7xfuV410116	rogid:RKOj1hwJ7LsEj9EUAkhlHjBkvYA10116	intact-crc:44F3A2176D02515F|rigid:9RVm0UBcqQF4k06RGKO89Bg16Q8	false	myc tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P19357	uniprotkb:P07633	intact:EBI-915426|uniprotkb:P97900|ensembl:ENSRNOP00000023256	intact:EBI-916076	psi-mi:glut4_rat(display_long)|uniprotkb:Glucose transporter type 4, insulin-responsive(gene name synonym)|uniprotkb:Slc2a4(gene name)|psi-mi:Slc2a4(display_short)|uniprotkb:Glut4(gene name synonym)	psi-mi:pccb_rat(display_long)|uniprotkb:Pccb(gene name)|psi-mi:Pccb(display_short)|uniprotkb:"Propanoyl-CoA:carbon dioxide ligase subunit beta"(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Foster et al. (2006)	pubmed:16396496|mint:MINT-5218203	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-921030	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2711|refseq:NP_036883.1|refseq:XP_006246658.1|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007611"(learning or memory)|go:"GO:0007614"(short-term memory)|go:"GO:0007616"(long-term memory)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010021"(amylopectin biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031550"(positive regulation of brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044381"(glucose import in response to insulin stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046323"(glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0098694"(regulation of synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0098793"(presynapse)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002441("Glucose transporter, type 4 (GLUT4)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-189200|ensembl:ENSRNOG00000017226(gene)|ensembl:ENSRNOT00000023256(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)	interpro:IPR011763(Acetyl-coenzyme A carboxyltransferase, C-terminal)|interpro:IPR011762(Acetyl-coenzyme A carboxyltransferase, N-terminal)|rgd:3265|interpro:IPR029045|interpro:IPR034733|go:"GO:0004658"(propionyl-CoA carboxylase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0009062"(fatty acid catabolic process)|go:"GO:0009063"(cellular amino acid catabolic process)|reactome:R-RNO-196780|reactome:R-RNO-71032	-	-	-	caution:"The participant EBI-349571(P68370) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919386(Q7TP47) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920972(Q5XIP9) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-916419(P11980) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919578(Q8R491) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920554(Q5U3Z7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920647(Q5U2X8) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920585(Q7TP24) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-779677(P05426) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-915744(P02454) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|agonist:Insulin was shown to increase or decrease GLUT4 protein interactions in specific cases.|comment:"Insulin decreased GLUT4 interactions with the following proteins: Q9ER30 (Sarcosin), P09527 (Rab-7), O88960 (N-ethylmaleimide sensitive), P09456 (PKA I regulatory subunit), P27881 (Hexokinase type II), P07872 (Acyl-coenzyme A oxidase), Q6DGF1 (Isocitrate dehydrogenase), Q9EQX9 (Ubiquitin-conjugating), Q63446 (Polyubiquitin), P24268 (Cathepsin D), Q91XW0 (Heat shock protein 86), Q5FVH0 (unknown), P58405 (Striatin 3), Q62667 (Major vault protein), Q66H50 (unknown), Q09167 (splicing factor), Q9JHU5 (Arfaptin 1)."|comment:"Insulin increased GLUT4 interaction with the following proteins:Q9Z1P2 (R-actinin-1), P45592 (Cofilin), Q9QXQ0 (R-actinin-4), P26473 (ADP-ribosylation factor), P26437 (ADP-ribosylation factor),   Q7TNP1 (Basigin 2), Q6P6R2 (Dihydrolipoamide dehydrogenase),   P04797 (GAPDH), Q63081 (Protein disulfide isomerase), P29457 (47 kDa heat shock protein), Q9R1J8 (Leprecan), O88638 (Putative eps protein),   Q64375 (Synaptonemal complex)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:NDPK - Interactions involving proteins containing InterPro domain IPR001564, Nucleoside diphosphate kinase, core.	taxid:10116(rat-l6)|taxid:10116(Rattus norvegicus)	-	2006/02/15	2021/11/30	rogid:PbFY2lfrty8yw40Jq7ShR7xfuV410116	rogid:MulZv8wZbivjONwRYFco8Od9k/M10116	intact-crc:44F3A2176D02515F|rigid:9RVm0UBcqQF4k06RGKO89Bg16Q8	false	myc tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P19357	uniprotkb:P07154	intact:EBI-915426|uniprotkb:P97900|ensembl:ENSRNOP00000023256	intact:EBI-916064|uniprotkb:Q9QV07|ensembl:ENSRNOP00000025462	psi-mi:glut4_rat(display_long)|uniprotkb:Glucose transporter type 4, insulin-responsive(gene name synonym)|uniprotkb:Slc2a4(gene name)|psi-mi:Slc2a4(display_short)|uniprotkb:Glut4(gene name synonym)	psi-mi:catl1_rat(display_long)|uniprotkb:Cathepsin L1(gene name synonym)|uniprotkb:Ctsl(gene name)|psi-mi:Ctsl(display_short)|uniprotkb:Ctsl1(gene name synonym)|uniprotkb:Cyclic protein 2(gene name synonym)|uniprotkb:Major excreted protein(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Foster et al. (2006)	pubmed:16396496|mint:MINT-5218203	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-921030	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2711|refseq:NP_036883.1|refseq:XP_006246658.1|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007611"(learning or memory)|go:"GO:0007614"(short-term memory)|go:"GO:0007616"(long-term memory)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010021"(amylopectin biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031550"(positive regulation of brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044381"(glucose import in response to insulin stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046323"(glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0098694"(regulation of synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0098793"(presynapse)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002441("Glucose transporter, type 4 (GLUT4)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-189200|ensembl:ENSRNOG00000017226(gene)|ensembl:ENSRNOT00000023256(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)	rgd:2448|refseq:NP_037288.1|go:"GO:0034698"(response to gonadotropin)|go:"GO:0039654"(fusion of virus membrane with host endosome membrane)|go:"GO:0042277"(peptide binding)|go:"GO:0042393"(histone binding)|go:"GO:0042583"(chromaffin granule)|go:"GO:0043005"(neuron projection)|go:"GO:0043204"(perikaryon)|go:"GO:0043373"(CD4-positive, alpha-beta T cell lineage commitment)|go:"GO:0043394"(proteoglycan binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046697"(decidualization)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0048002"(antigen processing and presentation of peptide antigen)|go:"GO:0048102"(autophagic cell death)|go:"GO:0051384"(response to glucocorticoid)|go:"GO:0051603"(proteolysis involved in cellular protein catabolic process)|go:"GO:0060008"(Sertoli cell differentiation)|go:"GO:0060309"(elastin catabolic process)|go:"GO:0097067"(cellular response to thyroid hormone stimulus)|go:"GO:0097655"(serpin family protein binding)|go:"GO:1990834"(response to odorant)|interpro:IPR000169(Peptidase, cysteine peptidase active site)|interpro:IPR000668(Peptidase C1A, papain C-terminal)|interpro:IPR013201(Proteinase inhibitor I29, cathepsin propeptide)|interpro:IPR025660|interpro:IPR025661|interpro:IPR038765|interpro:IPR039417|reactome:R-RNO-1442490|reactome:R-RNO-1474228|reactome:R-RNO-1679131|reactome:R-RNO-2022090|reactome:R-RNO-2132295|reactome:R-RNO-8939242|go:"GO:0009267"(cellular response to starvation)|go:"GO:0009749"(response to glucose)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0010259"(multicellular organism aging)|go:"GO:0010839"(negative regulation of keratinocyte proliferation)|go:"GO:0014070"(response to organic cyclic compound)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016540"(protein autoprocessing)|go:"GO:0016807"(cysteine-type carboxypeptidase activity)|go:"GO:0019064"(fusion of virus membrane with host plasma membrane)|go:"GO:0019065"(receptor-mediated endocytosis of virus by host cell)|go:"GO:0021675"(nerve development)|go:"GO:0030574"(collagen catabolic process)|go:"GO:0030984"(kininogen binding)|go:"GO:0031069"(hair follicle morphogenesis)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031638"(zymogen activation)|go:"GO:0034230"(enkephalin processing)|ensembl:ENSRNOG00000018566(gene)|ensembl:ENSRNOT00000025462(transcript)|go:"GO:0001968"(fibronectin binding)|go:"GO:0002250"(adaptive immune response)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004177"(aminopeptidase activity)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0005518"(collagen binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005773"(vacuole)|go:"GO:0005886"(plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0006508"(proteolysis)|go:"GO:0006590"(thyroid hormone generation)|go:"GO:0006955"(immune response)|go:"GO:0007154"(cell communication)|go:"GO:0007283"(spermatogenesis)|go:"GO:0008234"(cysteine-type peptidase activity)|go:"GO:0008584"(male gonad development)	-	-	-	caution:"The participant EBI-349571(P68370) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919386(Q7TP47) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920972(Q5XIP9) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-916419(P11980) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919578(Q8R491) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920554(Q5U3Z7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920647(Q5U2X8) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920585(Q7TP24) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-779677(P05426) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-915744(P02454) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|agonist:Insulin was shown to increase or decrease GLUT4 protein interactions in specific cases.|comment:"Insulin decreased GLUT4 interactions with the following proteins: Q9ER30 (Sarcosin), P09527 (Rab-7), O88960 (N-ethylmaleimide sensitive), P09456 (PKA I regulatory subunit), P27881 (Hexokinase type II), P07872 (Acyl-coenzyme A oxidase), Q6DGF1 (Isocitrate dehydrogenase), Q9EQX9 (Ubiquitin-conjugating), Q63446 (Polyubiquitin), P24268 (Cathepsin D), Q91XW0 (Heat shock protein 86), Q5FVH0 (unknown), P58405 (Striatin 3), Q62667 (Major vault protein), Q66H50 (unknown), Q09167 (splicing factor), Q9JHU5 (Arfaptin 1)."|comment:"Insulin increased GLUT4 interaction with the following proteins:Q9Z1P2 (R-actinin-1), P45592 (Cofilin), Q9QXQ0 (R-actinin-4), P26473 (ADP-ribosylation factor), P26437 (ADP-ribosylation factor),   Q7TNP1 (Basigin 2), Q6P6R2 (Dihydrolipoamide dehydrogenase),   P04797 (GAPDH), Q63081 (Protein disulfide isomerase), P29457 (47 kDa heat shock protein), Q9R1J8 (Leprecan), O88638 (Putative eps protein),   Q64375 (Synaptonemal complex)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:NDPK - Interactions involving proteins containing InterPro domain IPR001564, Nucleoside diphosphate kinase, core.	taxid:10116(rat-l6)|taxid:10116(Rattus norvegicus)	-	2006/02/15	2021/11/30	rogid:PbFY2lfrty8yw40Jq7ShR7xfuV410116	rogid:pyhow/eBi7OkcW3MAUchE+/QeWY10116	intact-crc:44F3A2176D02515F|rigid:9RVm0UBcqQF4k06RGKO89Bg16Q8	false	myc tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P19357	uniprotkb:P07153	intact:EBI-915426|uniprotkb:P97900|ensembl:ENSRNOP00000023256	intact:EBI-916056	psi-mi:glut4_rat(display_long)|uniprotkb:Glucose transporter type 4, insulin-responsive(gene name synonym)|uniprotkb:Slc2a4(gene name)|psi-mi:Slc2a4(display_short)|uniprotkb:Glut4(gene name synonym)	psi-mi:rpn1_rat(display_long)|uniprotkb:Rpn1(gene name)|psi-mi:Rpn1(display_short)|uniprotkb:Dolichyl-diphosphooligosaccharide--protein glycosyltransferase 67 kDa subunit(gene name synonym)|uniprotkb:Ribophorin-1(gene name synonym)|uniprotkb:Ribophorin I(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Foster et al. (2006)	pubmed:16396496|mint:MINT-5218203	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-921030	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2711|refseq:NP_036883.1|refseq:XP_006246658.1|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007611"(learning or memory)|go:"GO:0007614"(short-term memory)|go:"GO:0007616"(long-term memory)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010021"(amylopectin biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031550"(positive regulation of brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044381"(glucose import in response to insulin stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046323"(glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0098694"(regulation of synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0098793"(presynapse)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002441("Glucose transporter, type 4 (GLUT4)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-189200|ensembl:ENSRNOG00000017226(gene)|ensembl:ENSRNOT00000023256(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)	interpro:IPR007676(Ribophorin I)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0006487"(protein N-linked glycosylation)|go:"GO:0008250"(oligosaccharyltransferase complex)|go:"GO:0015833"(peptide transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0018279"(protein N-linked glycosylation via asparagine)|go:"GO:0042470"(melanosome)|rgd:3594|mint:P07153	-	-	-	caution:"The participant EBI-349571(P68370) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919386(Q7TP47) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920972(Q5XIP9) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-916419(P11980) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919578(Q8R491) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920554(Q5U3Z7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920647(Q5U2X8) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920585(Q7TP24) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-779677(P05426) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-915744(P02454) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|agonist:Insulin was shown to increase or decrease GLUT4 protein interactions in specific cases.|comment:"Insulin decreased GLUT4 interactions with the following proteins: Q9ER30 (Sarcosin), P09527 (Rab-7), O88960 (N-ethylmaleimide sensitive), P09456 (PKA I regulatory subunit), P27881 (Hexokinase type II), P07872 (Acyl-coenzyme A oxidase), Q6DGF1 (Isocitrate dehydrogenase), Q9EQX9 (Ubiquitin-conjugating), Q63446 (Polyubiquitin), P24268 (Cathepsin D), Q91XW0 (Heat shock protein 86), Q5FVH0 (unknown), P58405 (Striatin 3), Q62667 (Major vault protein), Q66H50 (unknown), Q09167 (splicing factor), Q9JHU5 (Arfaptin 1)."|comment:"Insulin increased GLUT4 interaction with the following proteins:Q9Z1P2 (R-actinin-1), P45592 (Cofilin), Q9QXQ0 (R-actinin-4), P26473 (ADP-ribosylation factor), P26437 (ADP-ribosylation factor),   Q7TNP1 (Basigin 2), Q6P6R2 (Dihydrolipoamide dehydrogenase),   P04797 (GAPDH), Q63081 (Protein disulfide isomerase), P29457 (47 kDa heat shock protein), Q9R1J8 (Leprecan), O88638 (Putative eps protein),   Q64375 (Synaptonemal complex)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:NDPK - Interactions involving proteins containing InterPro domain IPR001564, Nucleoside diphosphate kinase, core.	taxid:10116(rat-l6)|taxid:10116(Rattus norvegicus)	-	2006/02/15	2021/11/30	rogid:PbFY2lfrty8yw40Jq7ShR7xfuV410116	rogid:KiFPxBmGMrzA6l7xyCtPihBsz8s10116	intact-crc:44F3A2176D02515F|rigid:9RVm0UBcqQF4k06RGKO89Bg16Q8	false	myc tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P19357	uniprotkb:P07150	intact:EBI-915426|uniprotkb:P97900|ensembl:ENSRNOP00000023256	intact:EBI-916045|uniprotkb:Q64664|ensembl:ENSRNOP00000023664	psi-mi:glut4_rat(display_long)|uniprotkb:Glucose transporter type 4, insulin-responsive(gene name synonym)|uniprotkb:Slc2a4(gene name)|psi-mi:Slc2a4(display_short)|uniprotkb:Glut4(gene name synonym)	psi-mi:anxa1_rat(display_long)|uniprotkb:Anxa1(gene name)|psi-mi:Anxa1(display_short)|uniprotkb:Anx1(gene name synonym)|uniprotkb:Annexin-1(gene name synonym)|uniprotkb:Annexin I(gene name synonym)|uniprotkb:Lipocortin I(gene name synonym)|uniprotkb:Calpactin II(gene name synonym)|uniprotkb:Chromobindin-9(gene name synonym)|uniprotkb:p35(gene name synonym)|uniprotkb:Phospholipase A2 inhibitory protein(gene name synonym)|uniprotkb:Calpactin-2(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Foster et al. (2006)	pubmed:16396496|mint:MINT-5218203	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-921030	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2711|refseq:NP_036883.1|refseq:XP_006246658.1|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007611"(learning or memory)|go:"GO:0007614"(short-term memory)|go:"GO:0007616"(long-term memory)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010021"(amylopectin biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031550"(positive regulation of brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044381"(glucose import in response to insulin stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046323"(glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0098694"(regulation of synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0098793"(presynapse)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002441("Glucose transporter, type 4 (GLUT4)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-189200|ensembl:ENSRNOG00000017226(gene)|ensembl:ENSRNOT00000023256(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)	refseq:NP_037036.1|rgd:2118|refseq:XP_008758517.1|ensembl:ENSRNOG00000017469(gene)|ensembl:ENSRNOT00000023664(transcript)|go:"GO:0001533"(cornified envelope)|go:"GO:0001780"(neutrophil homeostasis)|go:"GO:0001891"(phagocytic cup)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002548"(monocyte chemotaxis)|go:"GO:0002685"(regulation of leukocyte migration)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005544"(calcium-dependent phospholipid binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005884"(actin filament)|go:"GO:0005886"(plasma membrane)|go:"GO:0006909"(phagocytosis)|go:"GO:0006954"(inflammatory response)|go:"GO:0007165"(signal transduction)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007187"(G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0009725"(response to hormone)|go:"GO:0009986"(cell surface)|go:"GO:0010165"(response to X-ray)|go:"GO:0014070"(response to organic cyclic compound)|go:"GO:0014839"(myoblast migration involved in skeletal muscle regeneration)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016328"(lateral plasma membrane)|go:"GO:0018149"(peptide cross-linking)|go:"GO:0019834"(phospholipase A2 inhibitor activity)|go:"GO:0019898"(extrinsic component of membrane)|go:"GO:0030073"(insulin secretion)|go:"GO:0030216"(keratinocyte differentiation)|go:"GO:0030850"(prostate gland development)|go:"GO:0031018"(endocrine pancreas development)|go:"GO:0031232"(extrinsic component of external side of plasma membrane)|go:"GO:0031313"(extrinsic component of endosome membrane)|go:"GO:0031340"(positive regulation of vesicle fusion)|go:"GO:0031394"(positive regulation of prostaglandin biosynthetic process)|go:"GO:0031514"(motile cilium)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0031901"(early endosome membrane)|go:"GO:0031960"(response to corticosteroid)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0032355"(response to estradiol)|go:"GO:0032508"(DNA duplex unwinding)|go:"GO:0032652"(regulation of interleukin-1 production)|go:"GO:0032717"(negative regulation of interleukin-8 production)|go:"GO:0032743"(positive regulation of interleukin-2 production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033031"(positive regulation of neutrophil apoptotic process)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|go:"GO:0036121"(double-stranded DNA helicase activity)|go:"GO:0042063"(gliogenesis)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0042493"|go:"GO:0042629"(mast cell granule)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043434"(response to peptide hormone)|go:"GO:0044849"(estrous cycle)|go:"GO:0045087"(innate immune response)|go:"GO:0045627"(positive regulation of T-helper 1 cell differentiation)|go:"GO:0045629"(negative regulation of T-helper 2 cell differentiation)|go:"GO:0045920"(negative regulation of exocytosis)|go:"GO:0046632"(alpha-beta T cell differentiation)|go:"GO:0046883"(regulation of hormone secretion)|go:"GO:0048306"(calcium-dependent protein binding)|go:"GO:0050482"(arachidonic acid secretion)|go:"GO:0050709"(negative regulation of protein secretion)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0051384"(response to glucocorticoid)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0070365"(hepatocyte differentiation)|go:"GO:0070459"(prolactin secretion)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0071385"(cellular response to glucocorticoid stimulus)|go:"GO:0071621"(granulocyte chemotaxis)|go:"GO:0090050"(positive regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0090303"(positive regulation of wound healing)|go:"GO:0097060"(synaptic membrane)|go:"GO:0097350"(neutrophil clearance)|go:"GO:1900087"(positive regulation of G1/S transition of mitotic cell cycle)|go:"GO:1900138"(negative regulation of phospholipase A2 activity)|go:"GO:1990814"(DNA/DNA annealing activity)|interpro:IPR001464(Annexin)|interpro:IPR002388(Annexin, type I)|interpro:IPR018252|interpro:IPR018502|interpro:IPR037104|reactome:R-RNO-416476|reactome:R-RNO-418594|reactome:R-RNO-444473	-	-	-	caution:"The participant EBI-349571(P68370) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919386(Q7TP47) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920972(Q5XIP9) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-916419(P11980) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919578(Q8R491) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920554(Q5U3Z7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920647(Q5U2X8) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920585(Q7TP24) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-779677(P05426) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-915744(P02454) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|agonist:Insulin was shown to increase or decrease GLUT4 protein interactions in specific cases.|comment:"Insulin decreased GLUT4 interactions with the following proteins: Q9ER30 (Sarcosin), P09527 (Rab-7), O88960 (N-ethylmaleimide sensitive), P09456 (PKA I regulatory subunit), P27881 (Hexokinase type II), P07872 (Acyl-coenzyme A oxidase), Q6DGF1 (Isocitrate dehydrogenase), Q9EQX9 (Ubiquitin-conjugating), Q63446 (Polyubiquitin), P24268 (Cathepsin D), Q91XW0 (Heat shock protein 86), Q5FVH0 (unknown), P58405 (Striatin 3), Q62667 (Major vault protein), Q66H50 (unknown), Q09167 (splicing factor), Q9JHU5 (Arfaptin 1)."|comment:"Insulin increased GLUT4 interaction with the following proteins:Q9Z1P2 (R-actinin-1), P45592 (Cofilin), Q9QXQ0 (R-actinin-4), P26473 (ADP-ribosylation factor), P26437 (ADP-ribosylation factor),   Q7TNP1 (Basigin 2), Q6P6R2 (Dihydrolipoamide dehydrogenase),   P04797 (GAPDH), Q63081 (Protein disulfide isomerase), P29457 (47 kDa heat shock protein), Q9R1J8 (Leprecan), O88638 (Putative eps protein),   Q64375 (Synaptonemal complex)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:NDPK - Interactions involving proteins containing InterPro domain IPR001564, Nucleoside diphosphate kinase, core.	taxid:10116(rat-l6)|taxid:10116(Rattus norvegicus)	-	2006/02/15	2021/11/30	rogid:PbFY2lfrty8yw40Jq7ShR7xfuV410116	rogid:stwhnd4HyVtBxO/rvSW2UZKYmmA10116	intact-crc:44F3A2176D02515F|rigid:9RVm0UBcqQF4k06RGKO89Bg16Q8	false	myc tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P19357	uniprotkb:P06761	intact:EBI-915426|uniprotkb:P97900|ensembl:ENSRNOP00000023256	intact:EBI-916036|ensembl:ENSRNOP00000025064	psi-mi:glut4_rat(display_long)|uniprotkb:Glucose transporter type 4, insulin-responsive(gene name synonym)|uniprotkb:Slc2a4(gene name)|psi-mi:Slc2a4(display_short)|uniprotkb:Glut4(gene name synonym)	psi-mi:bip_rat(display_long)|uniprotkb:Hspa5(gene name)|psi-mi:Hspa5(display_short)|uniprotkb:Grp78(gene name synonym)|uniprotkb:Immunoglobulin heavy chain-binding protein(gene name synonym)|uniprotkb:Steroidogenesis-activator polypeptide(gene name synonym)|uniprotkb:78 kDa glucose-regulated protein(gene name synonym)|uniprotkb:Binding-immunoglobulin protein(gene name synonym)|uniprotkb:Heat shock protein 70 family protein 5(gene name synonym)|uniprotkb:Heat shock protein family A member 5(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Foster et al. (2006)	pubmed:16396496|mint:MINT-5218203	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-921030	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2711|refseq:NP_036883.1|refseq:XP_006246658.1|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007611"(learning or memory)|go:"GO:0007614"(short-term memory)|go:"GO:0007616"(long-term memory)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010021"(amylopectin biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031550"(positive regulation of brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044381"(glucose import in response to insulin stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046323"(glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0098694"(regulation of synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0098793"(presynapse)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002441("Glucose transporter, type 4 (GLUT4)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-189200|ensembl:ENSRNOG00000017226(gene)|ensembl:ENSRNOT00000023256(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)	rgd:2843|refseq:NP_037215.1|ensembl:ENSRNOG00000018294(gene)|ensembl:ENSRNOT00000025067(transcript)|go:"GO:0001554"(luteolysis)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005790"(smooth endoplasmic reticulum)|go:"GO:0005793"(endoplasmic reticulum-Golgi intermediate compartment)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006983"(ER overload response)|go:"GO:0008180"(COP9 signalosome)|go:"GO:0009314"(response to radiation)|go:"GO:0009986"(cell surface)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0016020"(membrane)|go:"GO:0019899"(enzyme binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0021589"(cerebellum structural organization)|go:"GO:0021680"(cerebellar Purkinje cell layer development)|go:"GO:0030176"(integral component of endoplasmic reticulum membrane)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0030496"(midbody)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030968"(endoplasmic reticulum unfolded protein response)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031204"(posttranslational protein targeting to membrane, translocation)|go:"GO:0031333"(negative regulation of protein-containing complex assembly)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034620"(cellular response to unfolded protein)|go:"GO:0034663"(endoplasmic reticulum chaperone complex)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0035437"(maintenance of protein localization in endoplasmic reticulum)|go:"GO:0035690"|go:"GO:0036498"(IRE1-mediated unfolded protein response)|go:"GO:0042026"(protein refolding)|go:"GO:0042149"(cellular response to glucose starvation)|go:"GO:0042220"(response to cocaine)|go:"GO:0043022"(ribosome binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044183"(protein folding chaperone)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051085"(chaperone cofactor-dependent protein refolding)|go:"GO:0051402"(neuron apoptotic process)|go:"GO:0051603"(proteolysis involved in cellular protein catabolic process)|go:"GO:0051787"(misfolded protein binding)|go:"GO:0071236"(cellular response to antibiotic)|go:"GO:0071277"(cellular response to calcium ion)|go:"GO:0071287"(cellular response to manganese ion)|go:"GO:0071320"(cellular response to cAMP)|go:"GO:0071353"(cellular response to interleukin-4)|go:"GO:0071480"(cellular response to gamma radiation)|go:"GO:0097501"(stress response to metal ion)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1901998"(toxin transport)|go:"GO:1903895"(negative regulation of IRE1-mediated unfolded protein response)|go:"GO:1904313"(response to methamphetamine hydrochloride)|go:"GO:1990090"(cellular response to nerve growth factor stimulus)|interpro:IPR013126(Heat shock protein 70)|interpro:IPR018181|interpro:IPR029047|interpro:IPR029048|interpro:IPR042050|interpro:IPR043129|mint:P06761|reactome:R-RNO-3371453|reactome:R-RNO-983170	-	-	-	caution:"The participant EBI-349571(P68370) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919386(Q7TP47) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920972(Q5XIP9) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-916419(P11980) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919578(Q8R491) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920554(Q5U3Z7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920647(Q5U2X8) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920585(Q7TP24) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-779677(P05426) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-915744(P02454) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|agonist:Insulin was shown to increase or decrease GLUT4 protein interactions in specific cases.|comment:"Insulin decreased GLUT4 interactions with the following proteins: Q9ER30 (Sarcosin), P09527 (Rab-7), O88960 (N-ethylmaleimide sensitive), P09456 (PKA I regulatory subunit), P27881 (Hexokinase type II), P07872 (Acyl-coenzyme A oxidase), Q6DGF1 (Isocitrate dehydrogenase), Q9EQX9 (Ubiquitin-conjugating), Q63446 (Polyubiquitin), P24268 (Cathepsin D), Q91XW0 (Heat shock protein 86), Q5FVH0 (unknown), P58405 (Striatin 3), Q62667 (Major vault protein), Q66H50 (unknown), Q09167 (splicing factor), Q9JHU5 (Arfaptin 1)."|comment:"Insulin increased GLUT4 interaction with the following proteins:Q9Z1P2 (R-actinin-1), P45592 (Cofilin), Q9QXQ0 (R-actinin-4), P26473 (ADP-ribosylation factor), P26437 (ADP-ribosylation factor),   Q7TNP1 (Basigin 2), Q6P6R2 (Dihydrolipoamide dehydrogenase),   P04797 (GAPDH), Q63081 (Protein disulfide isomerase), P29457 (47 kDa heat shock protein), Q9R1J8 (Leprecan), O88638 (Putative eps protein),   Q64375 (Synaptonemal complex)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:NDPK - Interactions involving proteins containing InterPro domain IPR001564, Nucleoside diphosphate kinase, core.	taxid:10116(rat-l6)|taxid:10116(Rattus norvegicus)	-	2006/02/15	2021/11/30	rogid:PbFY2lfrty8yw40Jq7ShR7xfuV410116	rogid:5HRXkoNHYJvBA2iejRqltGRdJDw10116	intact-crc:44F3A2176D02515F|rigid:9RVm0UBcqQF4k06RGKO89Bg16Q8	false	myc tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P19357	uniprotkb:P06760	intact:EBI-915426|uniprotkb:P97900|ensembl:ENSRNOP00000023256	intact:EBI-916025	psi-mi:glut4_rat(display_long)|uniprotkb:Glucose transporter type 4, insulin-responsive(gene name synonym)|uniprotkb:Slc2a4(gene name)|psi-mi:Slc2a4(display_short)|uniprotkb:Glut4(gene name synonym)	psi-mi:bglr_rat(display_long)|uniprotkb:Gusb(gene name)|psi-mi:Gusb(display_short)|uniprotkb:Gus(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Foster et al. (2006)	pubmed:16396496|mint:MINT-5218203	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-921030	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2711|refseq:NP_036883.1|refseq:XP_006246658.1|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007611"(learning or memory)|go:"GO:0007614"(short-term memory)|go:"GO:0007616"(long-term memory)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010021"(amylopectin biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031550"(positive regulation of brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044381"(glucose import in response to insulin stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046323"(glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0098694"(regulation of synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0098793"(presynapse)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002441("Glucose transporter, type 4 (GLUT4)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-189200|ensembl:ENSRNOG00000017226(gene)|ensembl:ENSRNOT00000023256(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)	rgd:2772|refseq:NP_058711.2|interpro:IPR008979(Galactose-binding like)|interpro:IPR006103(Glycoside hydrolase family 2, TIM barrel)|interpro:IPR006101(Glycoside hydrolase, family 2)|interpro:IPR023232|interpro:IPR023230|interpro:IPR006102(Glycoside hydrolase family 2, immunoglobulin-like beta-sandwich)|interpro:IPR006104(Glycoside hydrolase family 2, carbohydrate-binding)|interpro:IPR017853(Glycoside hydrolase, catalytic core)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036156|reactome:R-RNO-2024096|reactome:R-RNO-6798695|reactome:R-RNO-2160916|go:"GO:0004566"(beta-glucuronidase activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005764"(lysosome)|go:"GO:0005975"(carbohydrate metabolic process)|go:"GO:0016787"(hydrolase activity)|go:"GO:0019391"(glucuronoside catabolic process)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030246"(carbohydrate binding)	-	-	-	caution:"The participant EBI-349571(P68370) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919386(Q7TP47) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920972(Q5XIP9) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-916419(P11980) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919578(Q8R491) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920554(Q5U3Z7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920647(Q5U2X8) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920585(Q7TP24) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-779677(P05426) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-915744(P02454) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|agonist:Insulin was shown to increase or decrease GLUT4 protein interactions in specific cases.|comment:"Insulin decreased GLUT4 interactions with the following proteins: Q9ER30 (Sarcosin), P09527 (Rab-7), O88960 (N-ethylmaleimide sensitive), P09456 (PKA I regulatory subunit), P27881 (Hexokinase type II), P07872 (Acyl-coenzyme A oxidase), Q6DGF1 (Isocitrate dehydrogenase), Q9EQX9 (Ubiquitin-conjugating), Q63446 (Polyubiquitin), P24268 (Cathepsin D), Q91XW0 (Heat shock protein 86), Q5FVH0 (unknown), P58405 (Striatin 3), Q62667 (Major vault protein), Q66H50 (unknown), Q09167 (splicing factor), Q9JHU5 (Arfaptin 1)."|comment:"Insulin increased GLUT4 interaction with the following proteins:Q9Z1P2 (R-actinin-1), P45592 (Cofilin), Q9QXQ0 (R-actinin-4), P26473 (ADP-ribosylation factor), P26437 (ADP-ribosylation factor),   Q7TNP1 (Basigin 2), Q6P6R2 (Dihydrolipoamide dehydrogenase),   P04797 (GAPDH), Q63081 (Protein disulfide isomerase), P29457 (47 kDa heat shock protein), Q9R1J8 (Leprecan), O88638 (Putative eps protein),   Q64375 (Synaptonemal complex)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:NDPK - Interactions involving proteins containing InterPro domain IPR001564, Nucleoside diphosphate kinase, core.	taxid:10116(rat-l6)|taxid:10116(Rattus norvegicus)	-	2006/02/15	2021/11/30	rogid:PbFY2lfrty8yw40Jq7ShR7xfuV410116	rogid:ipZRQkU8S1guObjxVqJtaezB4tU10116	intact-crc:44F3A2176D02515F|rigid:9RVm0UBcqQF4k06RGKO89Bg16Q8	false	myc tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P19357	uniprotkb:P63100	intact:EBI-915426|uniprotkb:P97900|ensembl:ENSRNOP00000023256	intact:EBI-916002|uniprotkb:P06705|uniprotkb:P15117|uniprotkb:Q08044|ensembl:ENSRNOP00000058834	psi-mi:glut4_rat(display_long)|uniprotkb:Glucose transporter type 4, insulin-responsive(gene name synonym)|uniprotkb:Slc2a4(gene name)|psi-mi:Slc2a4(display_short)|uniprotkb:Glut4(gene name synonym)	psi-mi:canb1_rat(display_long)|uniprotkb:Ppp3r1(gene name)|psi-mi:Ppp3r1(display_short)|uniprotkb:Cna2(gene name synonym)|uniprotkb:Cnb(gene name synonym)|uniprotkb:Protein phosphatase 2B regulatory subunit 1(gene name synonym)|uniprotkb:Protein phosphatase 3 regulatory subunit B alpha isoform 1(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Foster et al. (2006)	pubmed:16396496|mint:MINT-5218203	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-921030	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2711|refseq:NP_036883.1|refseq:XP_006246658.1|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007611"(learning or memory)|go:"GO:0007614"(short-term memory)|go:"GO:0007616"(long-term memory)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010021"(amylopectin biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031550"(positive regulation of brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044381"(glucose import in response to insulin stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046323"(glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0098694"(regulation of synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0098793"(presynapse)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002441("Glucose transporter, type 4 (GLUT4)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-189200|ensembl:ENSRNOG00000017226(gene)|ensembl:ENSRNOT00000023256(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)	rgd:69230|refseq:NP_059005.1|refseq:XP_006251579.3|ensembl:ENSRNOG00000043210(gene)|ensembl:ENSRNOT00000067846(transcript)|go:"GO:0001569"(branching involved in blood vessel morphogenesis)|go:"GO:0001837"(epithelial to mesenchymal transition)|go:"GO:0004721"(phosphoprotein phosphatase activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005829"(cytosol)|go:"GO:0005955"(calcineurin complex)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0007507"(heart development)|go:"GO:0008597"(calcium-dependent protein serine/threonine phosphatase regulator activity)|go:"GO:0014044"(Schwann cell development)|go:"GO:0016018"(cyclosporin A binding)|go:"GO:0019899"(enzyme binding)|go:"GO:0019902"(phosphatase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0022011"(myelination in peripheral nervous system)|go:"GO:0033173"(calcineurin-NFAT signaling cascade)|go:"GO:0034504"(protein localization to nucleus)|go:"GO:0042383"(sarcolemma)|go:"GO:0045202"(synapse)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0060487"(lung epithelial cell differentiation)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098688"(parallel fiber to Purkinje cell synapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099149"(regulation of postsynaptic neurotransmitter receptor internalization)|go:"GO:0099170"(postsynaptic modulation of chemical synaptic transmission)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR011992(EF-Hand type)|interpro:IPR015757(Calcineurin B protein)|interpro:IPR018247|rcsb pdb:4IL1|reactome:R-RNO-111447|reactome:R-RNO-2025928|reactome:R-RNO-2871809|reactome:R-RNO-4086398|reactome:R-RNO-5607763	-	-	-	caution:"The participant EBI-349571(P68370) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919386(Q7TP47) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920972(Q5XIP9) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-916419(P11980) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919578(Q8R491) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920554(Q5U3Z7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920647(Q5U2X8) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920585(Q7TP24) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-779677(P05426) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-915744(P02454) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|agonist:Insulin was shown to increase or decrease GLUT4 protein interactions in specific cases.|comment:"Insulin decreased GLUT4 interactions with the following proteins: Q9ER30 (Sarcosin), P09527 (Rab-7), O88960 (N-ethylmaleimide sensitive), P09456 (PKA I regulatory subunit), P27881 (Hexokinase type II), P07872 (Acyl-coenzyme A oxidase), Q6DGF1 (Isocitrate dehydrogenase), Q9EQX9 (Ubiquitin-conjugating), Q63446 (Polyubiquitin), P24268 (Cathepsin D), Q91XW0 (Heat shock protein 86), Q5FVH0 (unknown), P58405 (Striatin 3), Q62667 (Major vault protein), Q66H50 (unknown), Q09167 (splicing factor), Q9JHU5 (Arfaptin 1)."|comment:"Insulin increased GLUT4 interaction with the following proteins:Q9Z1P2 (R-actinin-1), P45592 (Cofilin), Q9QXQ0 (R-actinin-4), P26473 (ADP-ribosylation factor), P26437 (ADP-ribosylation factor),   Q7TNP1 (Basigin 2), Q6P6R2 (Dihydrolipoamide dehydrogenase),   P04797 (GAPDH), Q63081 (Protein disulfide isomerase), P29457 (47 kDa heat shock protein), Q9R1J8 (Leprecan), O88638 (Putative eps protein),   Q64375 (Synaptonemal complex)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:NDPK - Interactions involving proteins containing InterPro domain IPR001564, Nucleoside diphosphate kinase, core.	taxid:10116(rat-l6)|taxid:10116(Rattus norvegicus)	-	2006/02/15	2021/11/30	rogid:PbFY2lfrty8yw40Jq7ShR7xfuV410116	rogid:RqM4Q9x8EiLx7CyoF2Rvjl5RddM10116	intact-crc:44F3A2176D02515F|rigid:9RVm0UBcqQF4k06RGKO89Bg16Q8	false	myc tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P19357	uniprotkb:P41123	intact:EBI-915426|uniprotkb:P97900|ensembl:ENSRNOP00000023256	intact:EBI-917471|ensembl:ENSRNOP00000020635	psi-mi:glut4_rat(display_long)|uniprotkb:Glucose transporter type 4, insulin-responsive(gene name synonym)|uniprotkb:Slc2a4(gene name)|psi-mi:Slc2a4(display_short)|uniprotkb:Glut4(gene name synonym)	psi-mi:rl13_rat(display_long)|uniprotkb:Rpl13(gene name)|psi-mi:Rpl13(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Foster et al. (2006)	pubmed:16396496|mint:MINT-5218203	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-921030	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2711|refseq:NP_036883.1|refseq:XP_006246658.1|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007611"(learning or memory)|go:"GO:0007614"(short-term memory)|go:"GO:0007616"(long-term memory)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010021"(amylopectin biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031550"(positive regulation of brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044381"(glucose import in response to insulin stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046323"(glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0098694"(regulation of synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0098793"(presynapse)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002441("Glucose transporter, type 4 (GLUT4)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-189200|ensembl:ENSRNOG00000017226(gene)|ensembl:ENSRNOT00000023256(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)	rgd:621179|refseq:NP_112363.1|ensembl:ENSRNOG00000015335(gene)|ensembl:ENSRNOT00000020635(transcript)|go:"GO:0001824"(blastocyst development)|go:"GO:0003723"(RNA binding)|go:"GO:0003735"(structural constituent of ribosome)|go:"GO:0006412"(translation)|go:"GO:0022625"(cytosolic large ribosomal subunit)|go:"GO:0022626"(cytosolic ribosome)|go:"GO:0060348"(bone development)|go:"GO:0097421"(liver regeneration)|interpro:IPR001380(Ribosomal protein L13e)|interpro:IPR018256|mint:P41123|reactome:R-RNO-156827|reactome:R-RNO-1799339|reactome:R-RNO-6791226|reactome:R-RNO-72689|reactome:R-RNO-72706|reactome:R-RNO-975956|reactome:R-RNO-975957	-	-	-	caution:"The participant EBI-349571(P68370) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919386(Q7TP47) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920972(Q5XIP9) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-916419(P11980) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919578(Q8R491) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920554(Q5U3Z7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920647(Q5U2X8) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920585(Q7TP24) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-779677(P05426) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-915744(P02454) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|agonist:Insulin was shown to increase or decrease GLUT4 protein interactions in specific cases.|comment:"Insulin decreased GLUT4 interactions with the following proteins: Q9ER30 (Sarcosin), P09527 (Rab-7), O88960 (N-ethylmaleimide sensitive), P09456 (PKA I regulatory subunit), P27881 (Hexokinase type II), P07872 (Acyl-coenzyme A oxidase), Q6DGF1 (Isocitrate dehydrogenase), Q9EQX9 (Ubiquitin-conjugating), Q63446 (Polyubiquitin), P24268 (Cathepsin D), Q91XW0 (Heat shock protein 86), Q5FVH0 (unknown), P58405 (Striatin 3), Q62667 (Major vault protein), Q66H50 (unknown), Q09167 (splicing factor), Q9JHU5 (Arfaptin 1)."|comment:"Insulin increased GLUT4 interaction with the following proteins:Q9Z1P2 (R-actinin-1), P45592 (Cofilin), Q9QXQ0 (R-actinin-4), P26473 (ADP-ribosylation factor), P26437 (ADP-ribosylation factor),   Q7TNP1 (Basigin 2), Q6P6R2 (Dihydrolipoamide dehydrogenase),   P04797 (GAPDH), Q63081 (Protein disulfide isomerase), P29457 (47 kDa heat shock protein), Q9R1J8 (Leprecan), O88638 (Putative eps protein),   Q64375 (Synaptonemal complex)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:NDPK - Interactions involving proteins containing InterPro domain IPR001564, Nucleoside diphosphate kinase, core.	taxid:10116(rat-l6)|taxid:10116(Rattus norvegicus)	-	2006/02/15	2021/11/30	rogid:PbFY2lfrty8yw40Jq7ShR7xfuV410116	rogid:VaQ1k6Ys24FJswxJBjygrPBW8JE10116	intact-crc:44F3A2176D02515F|rigid:9RVm0UBcqQF4k06RGKO89Bg16Q8	false	myc tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P19357	uniprotkb:P40307	intact:EBI-915426|uniprotkb:P97900|ensembl:ENSRNOP00000023256	intact:EBI-917465|ensembl:ENSRNOP00000015618	psi-mi:glut4_rat(display_long)|uniprotkb:Glucose transporter type 4, insulin-responsive(gene name synonym)|uniprotkb:Slc2a4(gene name)|psi-mi:Slc2a4(display_short)|uniprotkb:Glut4(gene name synonym)	psi-mi:psb2_rat(display_long)|uniprotkb:Proteasome component C7-I(gene name synonym)|uniprotkb:Macropain subunit C7-I(gene name synonym)|uniprotkb:Multicatalytic endopeptidase complex subunit C7-I(gene name synonym)|uniprotkb:Psmb2(gene name)|psi-mi:Psmb2(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Foster et al. (2006)	pubmed:16396496|mint:MINT-5218203	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-921030	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2711|refseq:NP_036883.1|refseq:XP_006246658.1|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007611"(learning or memory)|go:"GO:0007614"(short-term memory)|go:"GO:0007616"(long-term memory)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010021"(amylopectin biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031550"(positive regulation of brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044381"(glucose import in response to insulin stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046323"(glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0098694"(regulation of synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0098793"(presynapse)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002441("Glucose transporter, type 4 (GLUT4)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-189200|ensembl:ENSRNOG00000017226(gene)|ensembl:ENSRNOT00000023256(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)	rgd:61874|refseq:NP_058980.1|ensembl:ENSRNOG00000011463(gene)|ensembl:ENSRNOT00000015618(transcript)|go:"GO:0000502"(proteasome complex)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004298"(threonine-type endopeptidase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005839"(proteasome core complex)|go:"GO:0010243"(response to organonitrogen compound)|go:"GO:0010499"(proteasomal ubiquitin-independent protein catabolic process)|go:"GO:0014070"(response to organic cyclic compound)|go:"GO:0019774"(proteasome core complex, beta-subunit complex)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|interpro:IPR001353(20S proteasome, A and B subunits)|interpro:IPR016050(Proteasome, beta-type subunit, conserved site)|interpro:IPR023333|interpro:IPR029055|interpro:IPR035206|rcsb pdb:6EPC|rcsb pdb:6EPD|rcsb pdb:6EPE|rcsb pdb:6EPF|rcsb pdb:6TU3|reactome:R-RNO-1169091|reactome:R-RNO-1234176|reactome:R-RNO-1236978|reactome:R-RNO-174084|reactome:R-RNO-174154|reactome:R-RNO-174178|reactome:R-RNO-174184|reactome:R-RNO-187577|reactome:R-RNO-195253|reactome:R-RNO-2467813|reactome:R-RNO-349425|reactome:R-RNO-350562|reactome:R-RNO-382556|reactome:R-RNO-450408|reactome:R-RNO-4608870|reactome:R-RNO-4641257|reactome:R-RNO-4641258|reactome:R-RNO-5358346|reactome:R-RNO-5607761|reactome:R-RNO-5610780|reactome:R-RNO-5610785|reactome:R-RNO-5632684|reactome:R-RNO-5658442|reactome:R-RNO-5668541|reactome:R-RNO-5676590|reactome:R-RNO-5687128|reactome:R-RNO-5689603|reactome:R-RNO-5689880|reactome:R-RNO-68827|reactome:R-RNO-68949|reactome:R-RNO-69017|reactome:R-RNO-69481|reactome:R-RNO-69601|reactome:R-RNO-75815|reactome:R-RNO-8852276|reactome:R-RNO-8854050|reactome:R-RNO-8932339|reactome:R-RNO-8939236|reactome:R-RNO-8941858|reactome:R-RNO-8948751|reactome:R-RNO-8951664|reactome:R-RNO-983168	-	-	-	caution:"The participant EBI-349571(P68370) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919386(Q7TP47) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920972(Q5XIP9) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-916419(P11980) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919578(Q8R491) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920554(Q5U3Z7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920647(Q5U2X8) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920585(Q7TP24) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-779677(P05426) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-915744(P02454) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|agonist:Insulin was shown to increase or decrease GLUT4 protein interactions in specific cases.|comment:"Insulin decreased GLUT4 interactions with the following proteins: Q9ER30 (Sarcosin), P09527 (Rab-7), O88960 (N-ethylmaleimide sensitive), P09456 (PKA I regulatory subunit), P27881 (Hexokinase type II), P07872 (Acyl-coenzyme A oxidase), Q6DGF1 (Isocitrate dehydrogenase), Q9EQX9 (Ubiquitin-conjugating), Q63446 (Polyubiquitin), P24268 (Cathepsin D), Q91XW0 (Heat shock protein 86), Q5FVH0 (unknown), P58405 (Striatin 3), Q62667 (Major vault protein), Q66H50 (unknown), Q09167 (splicing factor), Q9JHU5 (Arfaptin 1)."|comment:"Insulin increased GLUT4 interaction with the following proteins:Q9Z1P2 (R-actinin-1), P45592 (Cofilin), Q9QXQ0 (R-actinin-4), P26473 (ADP-ribosylation factor), P26437 (ADP-ribosylation factor),   Q7TNP1 (Basigin 2), Q6P6R2 (Dihydrolipoamide dehydrogenase),   P04797 (GAPDH), Q63081 (Protein disulfide isomerase), P29457 (47 kDa heat shock protein), Q9R1J8 (Leprecan), O88638 (Putative eps protein),   Q64375 (Synaptonemal complex)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:NDPK - Interactions involving proteins containing InterPro domain IPR001564, Nucleoside diphosphate kinase, core.	taxid:10116(rat-l6)|taxid:10116(Rattus norvegicus)	-	2006/02/15	2021/11/30	rogid:PbFY2lfrty8yw40Jq7ShR7xfuV410116	rogid:D/bl8YPG0qMkr7l/DrmoS48U0uY10116	intact-crc:44F3A2176D02515F|rigid:9RVm0UBcqQF4k06RGKO89Bg16Q8	false	myc tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P19357	uniprotkb:P40112	intact:EBI-915426|uniprotkb:P97900|ensembl:ENSRNOP00000023256	intact:EBI-917459|ensembl:ENSRNOP00000073805	psi-mi:glut4_rat(display_long)|uniprotkb:Glucose transporter type 4, insulin-responsive(gene name synonym)|uniprotkb:Slc2a4(gene name)|psi-mi:Slc2a4(display_short)|uniprotkb:Glut4(gene name synonym)	psi-mi:psb3_rat(display_long)|uniprotkb:Proteasome theta chain(gene name synonym)|uniprotkb:Proteasome chain 13(gene name synonym)|uniprotkb:Proteasome component C10-II(gene name synonym)|uniprotkb:Psmb3(gene name)|psi-mi:Psmb3(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Foster et al. (2006)	pubmed:16396496|mint:MINT-5218203	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-921030	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2711|refseq:NP_036883.1|refseq:XP_006246658.1|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007611"(learning or memory)|go:"GO:0007614"(short-term memory)|go:"GO:0007616"(long-term memory)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010021"(amylopectin biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031550"(positive regulation of brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044381"(glucose import in response to insulin stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046323"(glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0098694"(regulation of synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0098793"(presynapse)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002441("Glucose transporter, type 4 (GLUT4)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-189200|ensembl:ENSRNOG00000017226(gene)|ensembl:ENSRNOT00000023256(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)	rgd:61875|refseq:NP_058981.1|ensembl:ENSRNOG00000052730(gene)|ensembl:ENSRNOT00000086608(transcript)|go:"GO:0000502"(proteasome complex)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004298"(threonine-type endopeptidase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005839"(proteasome core complex)|go:"GO:0010499"(proteasomal ubiquitin-independent protein catabolic process)|go:"GO:0019774"(proteasome core complex, beta-subunit complex)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|interpro:IPR001353(20S proteasome, A and B subunits)|interpro:IPR016050(Proteasome, beta-type subunit, conserved site)|interpro:IPR023333|interpro:IPR029055|interpro:IPR033811|rcsb pdb:6EPC|rcsb pdb:6EPD|rcsb pdb:6EPE|rcsb pdb:6EPF|rcsb pdb:6TU3|reactome:R-RNO-1169091|reactome:R-RNO-1234176|reactome:R-RNO-1236978|reactome:R-RNO-174084|reactome:R-RNO-174154|reactome:R-RNO-174178|reactome:R-RNO-174184|reactome:R-RNO-187577|reactome:R-RNO-195253|reactome:R-RNO-2467813|reactome:R-RNO-349425|reactome:R-RNO-350562|reactome:R-RNO-382556|reactome:R-RNO-450408|reactome:R-RNO-4608870|reactome:R-RNO-4641257|reactome:R-RNO-4641258|reactome:R-RNO-5358346|reactome:R-RNO-5607761|reactome:R-RNO-5610780|reactome:R-RNO-5610785|reactome:R-RNO-5632684|reactome:R-RNO-5658442|reactome:R-RNO-5668541|reactome:R-RNO-5676590|reactome:R-RNO-5687128|reactome:R-RNO-5689603|reactome:R-RNO-5689880|reactome:R-RNO-68827|reactome:R-RNO-68949|reactome:R-RNO-69017|reactome:R-RNO-69481|reactome:R-RNO-69601|reactome:R-RNO-75815|reactome:R-RNO-8852276|reactome:R-RNO-8854050|reactome:R-RNO-8932339|reactome:R-RNO-8939236|reactome:R-RNO-8941858|reactome:R-RNO-8948751|reactome:R-RNO-8951664|reactome:R-RNO-983168	-	-	-	caution:"The participant EBI-349571(P68370) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919386(Q7TP47) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920972(Q5XIP9) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-916419(P11980) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919578(Q8R491) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920554(Q5U3Z7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920647(Q5U2X8) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920585(Q7TP24) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-779677(P05426) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-915744(P02454) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|agonist:Insulin was shown to increase or decrease GLUT4 protein interactions in specific cases.|comment:"Insulin decreased GLUT4 interactions with the following proteins: Q9ER30 (Sarcosin), P09527 (Rab-7), O88960 (N-ethylmaleimide sensitive), P09456 (PKA I regulatory subunit), P27881 (Hexokinase type II), P07872 (Acyl-coenzyme A oxidase), Q6DGF1 (Isocitrate dehydrogenase), Q9EQX9 (Ubiquitin-conjugating), Q63446 (Polyubiquitin), P24268 (Cathepsin D), Q91XW0 (Heat shock protein 86), Q5FVH0 (unknown), P58405 (Striatin 3), Q62667 (Major vault protein), Q66H50 (unknown), Q09167 (splicing factor), Q9JHU5 (Arfaptin 1)."|comment:"Insulin increased GLUT4 interaction with the following proteins:Q9Z1P2 (R-actinin-1), P45592 (Cofilin), Q9QXQ0 (R-actinin-4), P26473 (ADP-ribosylation factor), P26437 (ADP-ribosylation factor),   Q7TNP1 (Basigin 2), Q6P6R2 (Dihydrolipoamide dehydrogenase),   P04797 (GAPDH), Q63081 (Protein disulfide isomerase), P29457 (47 kDa heat shock protein), Q9R1J8 (Leprecan), O88638 (Putative eps protein),   Q64375 (Synaptonemal complex)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:NDPK - Interactions involving proteins containing InterPro domain IPR001564, Nucleoside diphosphate kinase, core.	taxid:10116(rat-l6)|taxid:10116(Rattus norvegicus)	-	2006/02/15	2021/11/30	rogid:PbFY2lfrty8yw40Jq7ShR7xfuV410116	rogid:gqzHAneLb73uZqnrh+KkV3S6Vxs10116	intact-crc:44F3A2176D02515F|rigid:9RVm0UBcqQF4k06RGKO89Bg16Q8	false	myc tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P19357	uniprotkb:P39052	intact:EBI-915426|uniprotkb:P97900|ensembl:ENSRNOP00000023256	intact:EBI-349613|ensembl:ENSRNOP00000010948	psi-mi:glut4_rat(display_long)|uniprotkb:Glucose transporter type 4, insulin-responsive(gene name synonym)|uniprotkb:Slc2a4(gene name)|psi-mi:Slc2a4(display_short)|uniprotkb:Glut4(gene name synonym)	psi-mi:dyn2_rat(display_long)|uniprotkb:Dnm2(gene name)|psi-mi:Dnm2(display_short)|uniprotkb:Dyn2(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Foster et al. (2006)	pubmed:16396496|mint:MINT-5218203	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-921030	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2711|refseq:NP_036883.1|refseq:XP_006246658.1|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007611"(learning or memory)|go:"GO:0007614"(short-term memory)|go:"GO:0007616"(long-term memory)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010021"(amylopectin biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031550"(positive regulation of brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044381"(glucose import in response to insulin stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046323"(glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0098694"(regulation of synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0098793"(presynapse)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002441("Glucose transporter, type 4 (GLUT4)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-189200|ensembl:ENSRNOG00000017226(gene)|ensembl:ENSRNOT00000023256(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)	rgd:2513|refseq:NP_037331.1|go:"GO:0006897"(endocytosis)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0006909"(phagocytosis)|go:"GO:0007283"(spermatogenesis)|go:"GO:0008017"(microtubule binding)|go:"GO:0009416"(response to light stimulus)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0016185"(synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0005768"(endosome)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030027"(lamellipodium)|go:"GO:0030054"(cell junction)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0030424"(axon)|go:"GO:0030496"(midbody)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030516"(regulation of axon extension)|go:"GO:0030670"(phagocytic vesicle membrane)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031623"(receptor internalization)|go:"GO:0031749"(D2 dopamine receptor binding)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0032587"(ruffle membrane)|go:"GO:0032991"(protein-containing complex)|go:"GO:0005813"(centrosome)|go:"GO:0033572"(transferrin transport)|go:"GO:0035020"(regulation of Rac protein signal transduction)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0005886"(plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0006893"(Golgi to plasma membrane transport)|go:"GO:0035904"(aorta development)|go:"GO:0036312"(phosphatidylinositol 3-kinase regulatory subunit binding)|go:"GO:0042220"(response to cocaine)|go:"GO:0044327"(dendritic spine head)|go:"GO:0044351"(macropinocytosis)|ensembl:ENSRNOG00000007649(gene)|ensembl:ENSRNOT00000010947(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0000266"(mitochondrial fission)|go:"GO:0001891"(phagocytic cup)|go:"GO:0001917"(photoreceptor inner segment)|go:"GO:0002031"(G protein-coupled receptor internalization)|go:"GO:0003281"(ventricular septum development)|go:"GO:0003374"(dynamin family protein polymerization involved in mitochondrial fission)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045334"(clathrin-coated endocytic vesicle)|go:"GO:0045429"(positive regulation of nitric oxide biosynthetic process)|go:"GO:0045807"(positive regulation of endocytosis)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048488"(synaptic vesicle endocytosis)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0050699"(WW domain binding)|go:"GO:0050766"(positive regulation of phagocytosis)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0050803"(regulation of synapse structure or activity)|go:"GO:0050998"(nitric-oxide synthase binding)|go:"GO:0060976"(coronary vasculature development)|go:"GO:0061025"(membrane fusion)|go:"GO:0071245"(cellular response to carbon monoxide)|go:"GO:0071481"(cellular response to X-ray)|go:"GO:0098793"(presynapse)|go:"GO:0098844"(postsynaptic endocytic zone membrane)|go:"GO:0098884"(postsynaptic neurotransmitter receptor internalization)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|go:"GO:1900026"(positive regulation of substrate adhesion-dependent cell spreading)|go:"GO:1902856"(negative regulation of non-motile cilium assembly)|go:"GO:1903351"(cellular response to dopamine)|go:"GO:1903358"(regulation of Golgi organization)|go:"GO:1903408"("positive regulation of P-type sodium:potassium-exchanging transporter activity")|go:"GO:1903526"(negative regulation of membrane tubulation)|go:"GO:2000370"(positive regulation of clathrin-dependent endocytosis)|interpro:IPR000375(Dynamin central region)|interpro:IPR001401(Dynamin, GTPase region)|go:"GO:0071732"(cellular response to nitric oxide)|interpro:IPR003130(Dynamin GTPase effector)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR019762|interpro:IPR020850|interpro:IPR022812|interpro:IPR027188|interpro:IPR027417|interpro:IPR030381|mint:P39052|reactome:R-RNO-190873|reactome:R-RNO-196025|reactome:R-RNO-203641|reactome:R-RNO-2132295|reactome:R-RNO-432720|reactome:R-RNO-432722|reactome:R-RNO-437239|reactome:R-RNO-8856828|interpro:IPR001849(Pleckstrin-like)|refseq:XP_006242670.1|refseq:XP_006242674.1|refseq:XP_006242675.1|dip:DIP-33275N	-	-	-	caution:"The participant EBI-349571(P68370) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919386(Q7TP47) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920972(Q5XIP9) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-916419(P11980) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919578(Q8R491) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920554(Q5U3Z7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920647(Q5U2X8) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920585(Q7TP24) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-779677(P05426) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-915744(P02454) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|agonist:Insulin was shown to increase or decrease GLUT4 protein interactions in specific cases.|comment:"Insulin decreased GLUT4 interactions with the following proteins: Q9ER30 (Sarcosin), P09527 (Rab-7), O88960 (N-ethylmaleimide sensitive), P09456 (PKA I regulatory subunit), P27881 (Hexokinase type II), P07872 (Acyl-coenzyme A oxidase), Q6DGF1 (Isocitrate dehydrogenase), Q9EQX9 (Ubiquitin-conjugating), Q63446 (Polyubiquitin), P24268 (Cathepsin D), Q91XW0 (Heat shock protein 86), Q5FVH0 (unknown), P58405 (Striatin 3), Q62667 (Major vault protein), Q66H50 (unknown), Q09167 (splicing factor), Q9JHU5 (Arfaptin 1)."|comment:"Insulin increased GLUT4 interaction with the following proteins:Q9Z1P2 (R-actinin-1), P45592 (Cofilin), Q9QXQ0 (R-actinin-4), P26473 (ADP-ribosylation factor), P26437 (ADP-ribosylation factor),   Q7TNP1 (Basigin 2), Q6P6R2 (Dihydrolipoamide dehydrogenase),   P04797 (GAPDH), Q63081 (Protein disulfide isomerase), P29457 (47 kDa heat shock protein), Q9R1J8 (Leprecan), O88638 (Putative eps protein),   Q64375 (Synaptonemal complex)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:NDPK - Interactions involving proteins containing InterPro domain IPR001564, Nucleoside diphosphate kinase, core.	taxid:10116(rat-l6)|taxid:10116(Rattus norvegicus)	-	2006/02/15	2021/11/30	rogid:PbFY2lfrty8yw40Jq7ShR7xfuV410116	rogid:3wEwbCVrr/RKqmxXaZ4PJRjl+v810116	intact-crc:44F3A2176D02515F|rigid:9RVm0UBcqQF4k06RGKO89Bg16Q8	false	myc tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P19357	uniprotkb:P62914	intact:EBI-915426|uniprotkb:P97900|ensembl:ENSRNOP00000023256	intact:EBI-438041|ensembl:ENSRNOP00000037110|uniprotkb:P25121|uniprotkb:P39026|uniprotkb:Q9Y674	psi-mi:glut4_rat(display_long)|uniprotkb:Glucose transporter type 4, insulin-responsive(gene name synonym)|uniprotkb:Slc2a4(gene name)|psi-mi:Slc2a4(display_short)|uniprotkb:Glut4(gene name synonym)	psi-mi:rl11_rat(display_long)|uniprotkb:Rpl11(gene name)|psi-mi:Rpl11(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Foster et al. (2006)	pubmed:16396496|mint:MINT-5218203	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-921030	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2711|refseq:NP_036883.1|refseq:XP_006246658.1|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007611"(learning or memory)|go:"GO:0007614"(short-term memory)|go:"GO:0007616"(long-term memory)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010021"(amylopectin biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031550"(positive regulation of brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044381"(glucose import in response to insulin stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046323"(glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0098694"(regulation of synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0098793"(presynapse)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002441("Glucose transporter, type 4 (GLUT4)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-189200|ensembl:ENSRNOG00000017226(gene)|ensembl:ENSRNOT00000023256(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)	ensembl:ENSRNOG00000026260(gene)|ensembl:ENSRNOT00000030043(transcript)|go:"GO:0000027"(ribosomal large subunit assembly)|go:"GO:0002181"(cytoplasmic translation)|go:"GO:0003723"(RNA binding)|go:"GO:0003735"(structural constituent of ribosome)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006364"(rRNA processing)|go:"GO:0006605"(protein targeting)|go:"GO:0008097"(5S rRNA binding)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0022625"(cytosolic large ribosomal subunit)|go:"GO:0022626"(cytosolic ribosome)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032435"(negative regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034504"(protein localization to nucleus)|go:"GO:0042273"(ribosomal large subunit biogenesis)|go:"GO:0042788"(polysomal ribosome)|go:"GO:0042975"(peroxisome proliferator activated receptor binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0045202"(synapse)|go:"GO:0050821"(protein stabilization)|go:"GO:1901796"(regulation of signal transduction by p53 class mediator)|go:"GO:1901798"(positive regulation of signal transduction by p53 class mediator)|go:"GO:1902255"(positive regulation of intrinsic apoptotic signaling pathway by p53 class mediator)|go:"GO:1904667"(negative regulation of ubiquitin protein ligase activity)|go:"GO:1990948"(ubiquitin ligase inhibitor activity)|go:"GO:2000059"(negative regulation of ubiquitin-dependent protein catabolic process)|go:"GO:2000435"(negative regulation of protein neddylation)|interpro:IPR002132(Ribosomal protein L5)|interpro:IPR020929|interpro:IPR022803|interpro:IPR031309|interpro:IPR031310|mint:P62914|reactome:R-RNO-156827|reactome:R-RNO-1799339|reactome:R-RNO-6791226|reactome:R-RNO-72689|reactome:R-RNO-72706|reactome:R-RNO-975956|reactome:R-RNO-975957|rgd:1308681|refseq:XP_006239286.1	-	-	-	caution:"The participant EBI-349571(P68370) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919386(Q7TP47) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920972(Q5XIP9) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-916419(P11980) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919578(Q8R491) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920554(Q5U3Z7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920647(Q5U2X8) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920585(Q7TP24) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-779677(P05426) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-915744(P02454) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|agonist:Insulin was shown to increase or decrease GLUT4 protein interactions in specific cases.|comment:"Insulin decreased GLUT4 interactions with the following proteins: Q9ER30 (Sarcosin), P09527 (Rab-7), O88960 (N-ethylmaleimide sensitive), P09456 (PKA I regulatory subunit), P27881 (Hexokinase type II), P07872 (Acyl-coenzyme A oxidase), Q6DGF1 (Isocitrate dehydrogenase), Q9EQX9 (Ubiquitin-conjugating), Q63446 (Polyubiquitin), P24268 (Cathepsin D), Q91XW0 (Heat shock protein 86), Q5FVH0 (unknown), P58405 (Striatin 3), Q62667 (Major vault protein), Q66H50 (unknown), Q09167 (splicing factor), Q9JHU5 (Arfaptin 1)."|comment:"Insulin increased GLUT4 interaction with the following proteins:Q9Z1P2 (R-actinin-1), P45592 (Cofilin), Q9QXQ0 (R-actinin-4), P26473 (ADP-ribosylation factor), P26437 (ADP-ribosylation factor),   Q7TNP1 (Basigin 2), Q6P6R2 (Dihydrolipoamide dehydrogenase),   P04797 (GAPDH), Q63081 (Protein disulfide isomerase), P29457 (47 kDa heat shock protein), Q9R1J8 (Leprecan), O88638 (Putative eps protein),   Q64375 (Synaptonemal complex)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:NDPK - Interactions involving proteins containing InterPro domain IPR001564, Nucleoside diphosphate kinase, core.	taxid:10116(rat-l6)|taxid:10116(Rattus norvegicus)	-	2006/02/15	2021/11/30	rogid:PbFY2lfrty8yw40Jq7ShR7xfuV410116	rogid:xt8XhDkfQPoH4DIPr0gC+ll766Q10116	intact-crc:44F3A2176D02515F|rigid:9RVm0UBcqQF4k06RGKO89Bg16Q8	false	myc tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P19357	uniprotkb:P38983	intact:EBI-915426|uniprotkb:P97900|ensembl:ENSRNOP00000023256	intact:EBI-917451|uniprotkb:B6ZB78|ensembl:ENSRNOP00000025224	psi-mi:glut4_rat(display_long)|uniprotkb:Glucose transporter type 4, insulin-responsive(gene name synonym)|uniprotkb:Slc2a4(gene name)|psi-mi:Slc2a4(display_short)|uniprotkb:Glut4(gene name synonym)	psi-mi:rssa_rat(display_long)|uniprotkb:Laminin receptor 1(gene name synonym)|uniprotkb:37/67 kDa laminin receptor(gene name synonym)|uniprotkb:Laminin-binding protein precursor p40(gene name synonym)|uniprotkb:Rpsa(gene name)|psi-mi:Rpsa(display_short)|uniprotkb:Lamr1(gene name synonym)|uniprotkb:37 kDa laminin receptor precursor(gene name synonym)|uniprotkb:67 kDa laminin receptor(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Foster et al. (2006)	pubmed:16396496|mint:MINT-5218203	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-921030	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2711|refseq:NP_036883.1|refseq:XP_006246658.1|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007611"(learning or memory)|go:"GO:0007614"(short-term memory)|go:"GO:0007616"(long-term memory)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010021"(amylopectin biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031550"(positive regulation of brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044381"(glucose import in response to insulin stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046323"(glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0098694"(regulation of synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0098793"(presynapse)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002441("Glucose transporter, type 4 (GLUT4)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-189200|ensembl:ENSRNOG00000017226(gene)|ensembl:ENSRNOT00000023256(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)	rgd:71026|refseq:NP_058834.1|ensembl:ENSRNOG00000018645(gene)|ensembl:ENSRNOT00000025225(transcript)|go:"GO:0000028"(ribosomal small subunit assembly)|go:"GO:0002181"(cytoplasmic translation)|go:"GO:0003735"(structural constituent of ribosome)|go:"GO:0005055"(laminin receptor activity)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005604"(basement membrane)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006412"(translation)|go:"GO:0015935"(small ribosomal subunit)|go:"GO:0016020"(membrane)|go:"GO:0022626"(cytosolic ribosome)|go:"GO:0022627"(cytosolic small ribosomal subunit)|go:"GO:0030855"(epithelial cell differentiation)|go:"GO:0043022"(ribosome binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043236"(laminin binding)|go:"GO:0045202"(synapse)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0098978"(glutamatergic synapse)|interpro:IPR001865(Ribosomal protein S2)|interpro:IPR005707(Ribosomal protein S2, eukaryotic/archaeal)|interpro:IPR018130|interpro:IPR023591|interpro:IPR027498|interpro:IPR027504|interpro:IPR032281|mint:P38983|reactome:R-RNO-156827|reactome:R-RNO-1799339|reactome:R-RNO-6791226|reactome:R-RNO-72649|reactome:R-RNO-72689|reactome:R-RNO-72695|reactome:R-RNO-72702|reactome:R-RNO-72706|reactome:R-RNO-975956|reactome:R-RNO-975957	-	-	-	caution:"The participant EBI-349571(P68370) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919386(Q7TP47) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920972(Q5XIP9) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-916419(P11980) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919578(Q8R491) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920554(Q5U3Z7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920647(Q5U2X8) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920585(Q7TP24) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-779677(P05426) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-915744(P02454) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|agonist:Insulin was shown to increase or decrease GLUT4 protein interactions in specific cases.|comment:"Insulin decreased GLUT4 interactions with the following proteins: Q9ER30 (Sarcosin), P09527 (Rab-7), O88960 (N-ethylmaleimide sensitive), P09456 (PKA I regulatory subunit), P27881 (Hexokinase type II), P07872 (Acyl-coenzyme A oxidase), Q6DGF1 (Isocitrate dehydrogenase), Q9EQX9 (Ubiquitin-conjugating), Q63446 (Polyubiquitin), P24268 (Cathepsin D), Q91XW0 (Heat shock protein 86), Q5FVH0 (unknown), P58405 (Striatin 3), Q62667 (Major vault protein), Q66H50 (unknown), Q09167 (splicing factor), Q9JHU5 (Arfaptin 1)."|comment:"Insulin increased GLUT4 interaction with the following proteins:Q9Z1P2 (R-actinin-1), P45592 (Cofilin), Q9QXQ0 (R-actinin-4), P26473 (ADP-ribosylation factor), P26437 (ADP-ribosylation factor),   Q7TNP1 (Basigin 2), Q6P6R2 (Dihydrolipoamide dehydrogenase),   P04797 (GAPDH), Q63081 (Protein disulfide isomerase), P29457 (47 kDa heat shock protein), Q9R1J8 (Leprecan), O88638 (Putative eps protein),   Q64375 (Synaptonemal complex)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:NDPK - Interactions involving proteins containing InterPro domain IPR001564, Nucleoside diphosphate kinase, core.	taxid:10116(rat-l6)|taxid:10116(Rattus norvegicus)	-	2006/02/15	2021/11/30	rogid:PbFY2lfrty8yw40Jq7ShR7xfuV410116	rogid:XVgtLKyvO/UwRSx+OqV7+lc98XI10116	intact-crc:44F3A2176D02515F|rigid:9RVm0UBcqQF4k06RGKO89Bg16Q8	false	myc tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P19357	uniprotkb:P38659	intact:EBI-915426|uniprotkb:P97900|ensembl:ENSRNOP00000023256	intact:EBI-917435|uniprotkb:Q6P7S5	psi-mi:glut4_rat(display_long)|uniprotkb:Glucose transporter type 4, insulin-responsive(gene name synonym)|uniprotkb:Slc2a4(gene name)|psi-mi:Slc2a4(display_short)|uniprotkb:Glut4(gene name synonym)	psi-mi:pdia4_rat(display_long)|uniprotkb:Endoplasmic reticulum resident protein 72(gene name synonym)|uniprotkb:Calcium-binding protein 2(gene name synonym)|uniprotkb:Pdia4(gene name)|psi-mi:Pdia4(display_short)|uniprotkb:Cabp2(gene name synonym)|uniprotkb:Erp70(gene name synonym)|uniprotkb:Endoplasmic reticulum resident protein 70(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Foster et al. (2006)	pubmed:16396496|mint:MINT-5218203	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-921030	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2711|refseq:NP_036883.1|refseq:XP_006246658.1|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007611"(learning or memory)|go:"GO:0007614"(short-term memory)|go:"GO:0007616"(long-term memory)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010021"(amylopectin biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031550"(positive regulation of brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044381"(glucose import in response to insulin stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046323"(glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0098694"(regulation of synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0098793"(presynapse)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002441("Glucose transporter, type 4 (GLUT4)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-189200|ensembl:ENSRNOG00000017226(gene)|ensembl:ENSRNOT00000023256(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)	interpro:IPR017937|interpro:IPR013766(Thioredoxin domain)|rcsb pdb:3EC3|rgd:619835|refseq:NP_446301.1|interpro:IPR005788(Disulphide isomerase)|interpro:IPR005792(Protein disulphide isomerase)|interpro:IPR017068(Protein disulphide-isomerase A4)|interpro:IPR036249|interpro:IPR041866|go:"GO:0003756"(protein disulfide isomerase activity)|go:"GO:0005615"(extracellular space)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005790"(smooth endoplasmic reticulum)|go:"GO:0006457"(protein folding)|go:"GO:0009986"(cell surface)|go:"GO:0015035"(protein-disulfide reductase activity)|go:"GO:0034663"(endoplasmic reticulum chaperone complex)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0042470"(melanosome)|go:"GO:0061077"(chaperone-mediated protein folding)|go:"GO:1903334"(positive regulation of protein folding)	-	-	-	caution:"The participant EBI-349571(P68370) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919386(Q7TP47) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920972(Q5XIP9) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-916419(P11980) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919578(Q8R491) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920554(Q5U3Z7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920647(Q5U2X8) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920585(Q7TP24) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-779677(P05426) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-915744(P02454) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|agonist:Insulin was shown to increase or decrease GLUT4 protein interactions in specific cases.|comment:"Insulin decreased GLUT4 interactions with the following proteins: Q9ER30 (Sarcosin), P09527 (Rab-7), O88960 (N-ethylmaleimide sensitive), P09456 (PKA I regulatory subunit), P27881 (Hexokinase type II), P07872 (Acyl-coenzyme A oxidase), Q6DGF1 (Isocitrate dehydrogenase), Q9EQX9 (Ubiquitin-conjugating), Q63446 (Polyubiquitin), P24268 (Cathepsin D), Q91XW0 (Heat shock protein 86), Q5FVH0 (unknown), P58405 (Striatin 3), Q62667 (Major vault protein), Q66H50 (unknown), Q09167 (splicing factor), Q9JHU5 (Arfaptin 1)."|comment:"Insulin increased GLUT4 interaction with the following proteins:Q9Z1P2 (R-actinin-1), P45592 (Cofilin), Q9QXQ0 (R-actinin-4), P26473 (ADP-ribosylation factor), P26437 (ADP-ribosylation factor),   Q7TNP1 (Basigin 2), Q6P6R2 (Dihydrolipoamide dehydrogenase),   P04797 (GAPDH), Q63081 (Protein disulfide isomerase), P29457 (47 kDa heat shock protein), Q9R1J8 (Leprecan), O88638 (Putative eps protein),   Q64375 (Synaptonemal complex)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:NDPK - Interactions involving proteins containing InterPro domain IPR001564, Nucleoside diphosphate kinase, core.	taxid:10116(rat-l6)|taxid:10116(Rattus norvegicus)	-	2006/02/15	2021/11/30	rogid:PbFY2lfrty8yw40Jq7ShR7xfuV410116	rogid:xv+wa/MMx9B97TWAWsJkg/YbjXQ10116	intact-crc:44F3A2176D02515F|rigid:9RVm0UBcqQF4k06RGKO89Bg16Q8	false	myc tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P19357	uniprotkb:P38650	intact:EBI-915426|uniprotkb:P97900|ensembl:ENSRNOP00000023256	intact:EBI-349489|uniprotkb:Q63178	psi-mi:glut4_rat(display_long)|uniprotkb:Glucose transporter type 4, insulin-responsive(gene name synonym)|uniprotkb:Slc2a4(gene name)|psi-mi:Slc2a4(display_short)|uniprotkb:Glut4(gene name synonym)	psi-mi:dyhc1_rat(display_long)|uniprotkb:Dync1h1(gene name)|psi-mi:Dync1h1(display_short)|uniprotkb:Dnch1(gene name synonym)|uniprotkb:Dnec1(gene name synonym)|uniprotkb:Map1c(gene name synonym)|uniprotkb:Dhc1(gene name synonym)|uniprotkb:Dyhc(gene name synonym)|uniprotkb:Cytoplasmic dynein heavy chain 1(gene name synonym)|uniprotkb:Dynein heavy chain, cytosolic(gene name synonym)|uniprotkb:MAP 1C(gene name synonym)|uniprotkb:Dnchc1(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Foster et al. (2006)	pubmed:16396496|mint:MINT-5218203	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-921030	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2711|refseq:NP_036883.1|refseq:XP_006246658.1|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007611"(learning or memory)|go:"GO:0007614"(short-term memory)|go:"GO:0007616"(long-term memory)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010021"(amylopectin biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031550"(positive regulation of brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044381"(glucose import in response to insulin stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046323"(glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0098694"(regulation of synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0098793"(presynapse)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002441("Glucose transporter, type 4 (GLUT4)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-189200|ensembl:ENSRNOG00000017226(gene)|ensembl:ENSRNOT00000023256(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)	rgd:2511|refseq:NP_062099.3|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR004273(Dynein heavy chain)|interpro:IPR024317|interpro:IPR013594(Dynein heavy chain, N-terminal region 1)|interpro:IPR013602(Dynein heavy chain, N-terminal region 2)|interpro:IPR024743|go:"GO:0005737"(cytoplasm)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0002177"(manchette)|go:"GO:0005524"(ATP binding)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005813"(centrosome)|go:"GO:0005868"(cytoplasmic dynein complex)|go:"GO:0005874"(microtubule)|go:"GO:0005881"(cytoplasmic microtubule)|go:"GO:0005938"(cell cortex)|go:"GO:0007018"(microtubule-based movement)|go:"GO:0007097"(nuclear migration)|go:"GO:0007286"(spermatid development)|go:"GO:0008090"(retrograde axonal transport)|go:"GO:0008569"(minus-end-directed microtubule motor activity)|go:"GO:0030175"(filopodium)|go:"GO:0030286"(dynein complex)|go:"GO:0030424"(axon)|go:"GO:0031122"(cytoplasmic microtubule organization)|go:"GO:0032388"(positive regulation of intracellular transport)|go:"GO:0034063"(stress granule assembly)|go:"GO:0043025"(neuronal cell body)|go:"GO:0033962"(P-body assembly)|go:"GO:0045505"(dynein intermediate chain binding)|go:"GO:0051293"(establishment of spindle localization)|go:"GO:0051301"(cell division)|go:"GO:0051959"(dynein light intermediate chain binding)|go:"GO:0060236"(regulation of mitotic spindle organization)|go:"GO:0072382"(minus-end-directed vesicle transport along microtubule)|go:"GO:0090235"(regulation of metaphase plate congression)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:1904115"(axon cytoplasm)|go:"GO:1905243"(cellular response to 3,3',5-triiodo-L-thyronine)|go:"GO:1905832"(positive regulation of spindle assembly)|go:"GO:1990090"(cellular response to nerve growth factor stimulus)|reactome:R-RNO-141444|reactome:R-RNO-2132295|reactome:R-RNO-2467813|reactome:R-RNO-2500257|reactome:R-RNO-2565942|reactome:R-RNO-3371497|reactome:R-RNO-380259|reactome:R-RNO-380270|reactome:R-RNO-380284|reactome:R-RNO-380320|reactome:R-RNO-5620912|reactome:R-RNO-5663220|reactome:R-RNO-6798695|reactome:R-RNO-6807878|reactome:R-RNO-6811436|reactome:R-RNO-68877|reactome:R-RNO-8854518|reactome:R-RNO-9646399|reactome:R-RNO-9648025|interpro:IPR042219|interpro:IPR042222|interpro:IPR042228|interpro:IPR027417|mint:P38650|interpro:IPR035699|interpro:IPR035706|interpro:IPR041228|interpro:IPR041466|interpro:IPR041658|interpro:IPR043157|interpro:IPR043160	-	-	-	caution:"The participant EBI-349571(P68370) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919386(Q7TP47) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920972(Q5XIP9) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-916419(P11980) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919578(Q8R491) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920554(Q5U3Z7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920647(Q5U2X8) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920585(Q7TP24) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-779677(P05426) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-915744(P02454) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|agonist:Insulin was shown to increase or decrease GLUT4 protein interactions in specific cases.|comment:"Insulin decreased GLUT4 interactions with the following proteins: Q9ER30 (Sarcosin), P09527 (Rab-7), O88960 (N-ethylmaleimide sensitive), P09456 (PKA I regulatory subunit), P27881 (Hexokinase type II), P07872 (Acyl-coenzyme A oxidase), Q6DGF1 (Isocitrate dehydrogenase), Q9EQX9 (Ubiquitin-conjugating), Q63446 (Polyubiquitin), P24268 (Cathepsin D), Q91XW0 (Heat shock protein 86), Q5FVH0 (unknown), P58405 (Striatin 3), Q62667 (Major vault protein), Q66H50 (unknown), Q09167 (splicing factor), Q9JHU5 (Arfaptin 1)."|comment:"Insulin increased GLUT4 interaction with the following proteins:Q9Z1P2 (R-actinin-1), P45592 (Cofilin), Q9QXQ0 (R-actinin-4), P26473 (ADP-ribosylation factor), P26437 (ADP-ribosylation factor),   Q7TNP1 (Basigin 2), Q6P6R2 (Dihydrolipoamide dehydrogenase),   P04797 (GAPDH), Q63081 (Protein disulfide isomerase), P29457 (47 kDa heat shock protein), Q9R1J8 (Leprecan), O88638 (Putative eps protein),   Q64375 (Synaptonemal complex)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:NDPK - Interactions involving proteins containing InterPro domain IPR001564, Nucleoside diphosphate kinase, core.	taxid:10116(rat-l6)|taxid:10116(Rattus norvegicus)	-	2006/02/15	2021/11/30	rogid:PbFY2lfrty8yw40Jq7ShR7xfuV410116	rogid:RxE6eIUsLysOcDObdE+E7cBOC5w10116	intact-crc:44F3A2176D02515F|rigid:9RVm0UBcqQF4k06RGKO89Bg16Q8	false	myc tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P19357	uniprotkb:P37397	intact:EBI-915426|uniprotkb:P97900|ensembl:ENSRNOP00000023256	intact:EBI-917421|ensembl:ENSRNOP00000015579	psi-mi:glut4_rat(display_long)|uniprotkb:Glucose transporter type 4, insulin-responsive(gene name synonym)|uniprotkb:Slc2a4(gene name)|psi-mi:Slc2a4(display_short)|uniprotkb:Glut4(gene name synonym)	psi-mi:cnn3_rat(display_long)|uniprotkb:Calponin, acidic isoform(gene name synonym)|uniprotkb:Calponin, non-muscle isoform(gene name synonym)|uniprotkb:Cnn3(gene name)|psi-mi:Cnn3(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Foster et al. (2006)	pubmed:16396496|mint:MINT-5218203	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-921030	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2711|refseq:NP_036883.1|refseq:XP_006246658.1|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007611"(learning or memory)|go:"GO:0007614"(short-term memory)|go:"GO:0007616"(long-term memory)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010021"(amylopectin biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031550"(positive regulation of brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044381"(glucose import in response to insulin stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046323"(glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0098694"(regulation of synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0098793"(presynapse)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002441("Glucose transporter, type 4 (GLUT4)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-189200|ensembl:ENSRNOG00000017226(gene)|ensembl:ENSRNOT00000023256(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)	rgd:71044|refseq:NP_062232.1|ensembl:ENSRNOG00000011559(gene)|ensembl:ENSRNOT00000015579(transcript)|go:"GO:0003779"(actin binding)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0005884"(actin filament)|go:"GO:0008017"(microtubule binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0030425"(dendrite)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0030855"(epithelial cell differentiation)|go:"GO:0031032"(actomyosin structure organization)|go:"GO:0032780"(negative regulation of ATP-dependent activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043197"(dendritic spine)|interpro:IPR000557(Calponin repeat)|interpro:IPR001715(Calponin-like actin-binding)|interpro:IPR001997(Calponin)|interpro:IPR003096(SM22/calponin)|interpro:IPR036872	-	-	-	caution:"The participant EBI-349571(P68370) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919386(Q7TP47) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920972(Q5XIP9) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-916419(P11980) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919578(Q8R491) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920554(Q5U3Z7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920647(Q5U2X8) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920585(Q7TP24) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-779677(P05426) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-915744(P02454) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|agonist:Insulin was shown to increase or decrease GLUT4 protein interactions in specific cases.|comment:"Insulin decreased GLUT4 interactions with the following proteins: Q9ER30 (Sarcosin), P09527 (Rab-7), O88960 (N-ethylmaleimide sensitive), P09456 (PKA I regulatory subunit), P27881 (Hexokinase type II), P07872 (Acyl-coenzyme A oxidase), Q6DGF1 (Isocitrate dehydrogenase), Q9EQX9 (Ubiquitin-conjugating), Q63446 (Polyubiquitin), P24268 (Cathepsin D), Q91XW0 (Heat shock protein 86), Q5FVH0 (unknown), P58405 (Striatin 3), Q62667 (Major vault protein), Q66H50 (unknown), Q09167 (splicing factor), Q9JHU5 (Arfaptin 1)."|comment:"Insulin increased GLUT4 interaction with the following proteins:Q9Z1P2 (R-actinin-1), P45592 (Cofilin), Q9QXQ0 (R-actinin-4), P26473 (ADP-ribosylation factor), P26437 (ADP-ribosylation factor),   Q7TNP1 (Basigin 2), Q6P6R2 (Dihydrolipoamide dehydrogenase),   P04797 (GAPDH), Q63081 (Protein disulfide isomerase), P29457 (47 kDa heat shock protein), Q9R1J8 (Leprecan), O88638 (Putative eps protein),   Q64375 (Synaptonemal complex)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:NDPK - Interactions involving proteins containing InterPro domain IPR001564, Nucleoside diphosphate kinase, core.	taxid:10116(rat-l6)|taxid:10116(Rattus norvegicus)	-	2006/02/15	2021/11/30	rogid:PbFY2lfrty8yw40Jq7ShR7xfuV410116	rogid:VR/IWmnF12fGjqc1g/bdBjW4aUg10116	intact-crc:44F3A2176D02515F|rigid:9RVm0UBcqQF4k06RGKO89Bg16Q8	false	myc tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P19357	uniprotkb:P37285	intact:EBI-915426|uniprotkb:P97900|ensembl:ENSRNOP00000023256	intact:EBI-917396|ensembl:ENSRNOP00000075931	psi-mi:glut4_rat(display_long)|uniprotkb:Glucose transporter type 4, insulin-responsive(gene name synonym)|uniprotkb:Slc2a4(gene name)|psi-mi:Slc2a4(display_short)|uniprotkb:Glut4(gene name synonym)	psi-mi:klc1_rat(display_long)|uniprotkb:Klc1(gene name)|psi-mi:Klc1(display_short)|uniprotkb:Klc(gene name synonym)|uniprotkb:Kns2(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Foster et al. (2006)	pubmed:16396496|mint:MINT-5218203	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-921030	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2711|refseq:NP_036883.1|refseq:XP_006246658.1|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007611"(learning or memory)|go:"GO:0007614"(short-term memory)|go:"GO:0007616"(long-term memory)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010021"(amylopectin biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031550"(positive regulation of brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044381"(glucose import in response to insulin stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046323"(glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0098694"(regulation of synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0098793"(presynapse)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002441("Glucose transporter, type 4 (GLUT4)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-189200|ensembl:ENSRNOG00000017226(gene)|ensembl:ENSRNOT00000023256(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)	rgd:621411|refseq:NP_001075442.1|refseq:NP_001075443.1|dip:DIP-36927N|ensembl:ENSRNOG00000011572(gene)|ensembl:ENSRNOT00000092774(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005871"(kinesin complex)|go:"GO:0005874"(microtubule)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0008088"(axo-dendritic transport)|go:"GO:0015631"(tubulin binding)|go:"GO:0016020"(membrane)|go:"GO:0030424"(axon)|go:"GO:0030426"(growth cone)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031982"(vesicle)|go:"GO:0035253"(ciliary rootlet)|go:"GO:0035418"(protein localization to synapse)|go:"GO:0035617"(stress granule disassembly)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043227"(membrane-bounded organelle)|interpro:IPR002151(Kinesin light chain)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR015792(Kinesin light chain repeat)|interpro:IPR019734|mint:P37285|reactome:R-RNO-2132295|reactome:R-RNO-5625970|reactome:R-RNO-6811434|reactome:R-RNO-983189	-	-	-	caution:"The participant EBI-349571(P68370) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919386(Q7TP47) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920972(Q5XIP9) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-916419(P11980) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919578(Q8R491) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920554(Q5U3Z7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920647(Q5U2X8) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920585(Q7TP24) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-779677(P05426) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-915744(P02454) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|agonist:Insulin was shown to increase or decrease GLUT4 protein interactions in specific cases.|comment:"Insulin decreased GLUT4 interactions with the following proteins: Q9ER30 (Sarcosin), P09527 (Rab-7), O88960 (N-ethylmaleimide sensitive), P09456 (PKA I regulatory subunit), P27881 (Hexokinase type II), P07872 (Acyl-coenzyme A oxidase), Q6DGF1 (Isocitrate dehydrogenase), Q9EQX9 (Ubiquitin-conjugating), Q63446 (Polyubiquitin), P24268 (Cathepsin D), Q91XW0 (Heat shock protein 86), Q5FVH0 (unknown), P58405 (Striatin 3), Q62667 (Major vault protein), Q66H50 (unknown), Q09167 (splicing factor), Q9JHU5 (Arfaptin 1)."|comment:"Insulin increased GLUT4 interaction with the following proteins:Q9Z1P2 (R-actinin-1), P45592 (Cofilin), Q9QXQ0 (R-actinin-4), P26473 (ADP-ribosylation factor), P26437 (ADP-ribosylation factor),   Q7TNP1 (Basigin 2), Q6P6R2 (Dihydrolipoamide dehydrogenase),   P04797 (GAPDH), Q63081 (Protein disulfide isomerase), P29457 (47 kDa heat shock protein), Q9R1J8 (Leprecan), O88638 (Putative eps protein),   Q64375 (Synaptonemal complex)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:NDPK - Interactions involving proteins containing InterPro domain IPR001564, Nucleoside diphosphate kinase, core.	taxid:10116(rat-l6)|taxid:10116(Rattus norvegicus)	-	2006/02/15	2021/11/30	rogid:PbFY2lfrty8yw40Jq7ShR7xfuV410116	rogid:4o3poOHtmPnoLq/XTguA0Z1P14o10116	intact-crc:44F3A2176D02515F|rigid:9RVm0UBcqQF4k06RGKO89Bg16Q8	false	myc tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P19357	uniprotkb:P63088	intact:EBI-915426|uniprotkb:P97900|ensembl:ENSRNOP00000023256	intact:EBI-80049|uniprotkb:O09186|uniprotkb:O09189|uniprotkb:P37139|uniprotkb:Q64679|ensembl:ENSRNOP00000071829	psi-mi:glut4_rat(display_long)|uniprotkb:Glucose transporter type 4, insulin-responsive(gene name synonym)|uniprotkb:Slc2a4(gene name)|psi-mi:Slc2a4(display_short)|uniprotkb:Glut4(gene name synonym)	psi-mi:pp1g_rat(display_long)|uniprotkb:Ppp1cc(gene name)|psi-mi:Ppp1cc(display_short)|uniprotkb:Protein phosphatase 1C catalytic subunit(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Foster et al. (2006)	pubmed:16396496|mint:MINT-5218203	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-921030	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2711|refseq:NP_036883.1|refseq:XP_006246658.1|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007611"(learning or memory)|go:"GO:0007614"(short-term memory)|go:"GO:0007616"(long-term memory)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010021"(amylopectin biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031550"(positive regulation of brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044381"(glucose import in response to insulin stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046323"(glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0098694"(regulation of synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0098793"(presynapse)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002441("Glucose transporter, type 4 (GLUT4)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-189200|ensembl:ENSRNOG00000017226(gene)|ensembl:ENSRNOT00000023256(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)	refseq:NP_071943.1|ensembl:ENSRNOG00000001269(gene)|ensembl:ENSRNOT00000078761(transcript)|go:"GO:0000164"(protein phosphatase type 1 complex)|go:"GO:0000776"(kinetochore)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0004722"(protein serine/threonine phosphatase activity)|go:"GO:0005521"(lamin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005977"(glycogen metabolic process)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0007049"(cell cycle)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008157"(protein phosphatase 1 binding)|go:"GO:0016607"(nuclear speck)|go:"GO:0016791"(phosphatase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030496"(midbody)|go:"GO:0032154"(cleavage furrow)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0043153"(entrainment of circadian clock by photoperiod)|go:"GO:0043197"(dendritic spine)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046822"(regulation of nucleocytoplasmic transport)|go:"GO:0046872"(metal ion binding)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0051301"(cell division)|go:"GO:0060252"(positive regulation of glial cell proliferation)|go:"GO:0072357"(PTW/PP1 phosphatase complex)|go:"GO:0098793"(presynapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0106306"|go:"GO:0106307"|interpro:IPR004843(Metallophosphoesterase)|interpro:IPR006186("Serine/threonine-specific protein phosphatase and bis(5-nucleosyl)-tetraphosphatase")|interpro:IPR029052|interpro:IPR031675|interpro:IPR037981|mint:P63088|rcsb pdb:2O8A|rcsb pdb:2O8G|reactome:R-RNO-141444|reactome:R-RNO-2467813|reactome:R-RNO-2500257|reactome:R-RNO-5663220|reactome:R-RNO-5673000|reactome:R-RNO-68877|reactome:R-RNO-9648025|rgd:3377	-	-	-	caution:"The participant EBI-349571(P68370) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919386(Q7TP47) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920972(Q5XIP9) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-916419(P11980) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919578(Q8R491) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920554(Q5U3Z7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920647(Q5U2X8) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920585(Q7TP24) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-779677(P05426) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-915744(P02454) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|agonist:Insulin was shown to increase or decrease GLUT4 protein interactions in specific cases.|comment:"Insulin decreased GLUT4 interactions with the following proteins: Q9ER30 (Sarcosin), P09527 (Rab-7), O88960 (N-ethylmaleimide sensitive), P09456 (PKA I regulatory subunit), P27881 (Hexokinase type II), P07872 (Acyl-coenzyme A oxidase), Q6DGF1 (Isocitrate dehydrogenase), Q9EQX9 (Ubiquitin-conjugating), Q63446 (Polyubiquitin), P24268 (Cathepsin D), Q91XW0 (Heat shock protein 86), Q5FVH0 (unknown), P58405 (Striatin 3), Q62667 (Major vault protein), Q66H50 (unknown), Q09167 (splicing factor), Q9JHU5 (Arfaptin 1)."|comment:"Insulin increased GLUT4 interaction with the following proteins:Q9Z1P2 (R-actinin-1), P45592 (Cofilin), Q9QXQ0 (R-actinin-4), P26473 (ADP-ribosylation factor), P26437 (ADP-ribosylation factor),   Q7TNP1 (Basigin 2), Q6P6R2 (Dihydrolipoamide dehydrogenase),   P04797 (GAPDH), Q63081 (Protein disulfide isomerase), P29457 (47 kDa heat shock protein), Q9R1J8 (Leprecan), O88638 (Putative eps protein),   Q64375 (Synaptonemal complex)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:NDPK - Interactions involving proteins containing InterPro domain IPR001564, Nucleoside diphosphate kinase, core.	taxid:10116(rat-l6)|taxid:10116(Rattus norvegicus)	-	2006/02/15	2021/11/30	rogid:PbFY2lfrty8yw40Jq7ShR7xfuV410116	rogid:67YjuOIxqIl6Qj+bQnfLBo4iRAg10116	intact-crc:44F3A2176D02515F|rigid:9RVm0UBcqQF4k06RGKO89Bg16Q8	false	myc tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P19357	uniprotkb:P36972	intact:EBI-915426|uniprotkb:P97900|ensembl:ENSRNOP00000023256	intact:EBI-917389|ensembl:ENSRNOP00000061449	psi-mi:glut4_rat(display_long)|uniprotkb:Glucose transporter type 4, insulin-responsive(gene name synonym)|uniprotkb:Slc2a4(gene name)|psi-mi:Slc2a4(display_short)|uniprotkb:Glut4(gene name synonym)	psi-mi:apt_rat(display_long)|uniprotkb:Aprt(gene name)|psi-mi:Aprt(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Foster et al. (2006)	pubmed:16396496|mint:MINT-5218203	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-921030	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2711|refseq:NP_036883.1|refseq:XP_006246658.1|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007611"(learning or memory)|go:"GO:0007614"(short-term memory)|go:"GO:0007616"(long-term memory)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010021"(amylopectin biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031550"(positive regulation of brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044381"(glucose import in response to insulin stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046323"(glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0098694"(regulation of synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0098793"(presynapse)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002441("Glucose transporter, type 4 (GLUT4)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-189200|ensembl:ENSRNOG00000017226(gene)|ensembl:ENSRNOT00000023256(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)	rgd:1307758|refseq:NP_001013079.1|ensembl:ENSRNOG00000014405(gene)|ensembl:ENSRNOT00000064180(transcript)|go:"GO:0002055"(adenine binding)|go:"GO:0003999"(adenine phosphoribosyltransferase activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006166"(purine ribonucleoside salvage)|go:"GO:0006168"(adenine salvage)|go:"GO:0007595"(lactation)|go:"GO:0007625"(grooming behavior)|go:"GO:0016208"(AMP binding)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0044209"(AMP salvage)|go:"GO:0046083"(adenine metabolic process)|interpro:IPR000836(Phosphoribosyltransferase)|interpro:IPR005764(Adenine phosphoribosyl transferase)|interpro:IPR029057|mint:P36972|reactome:R-RNO-6798695|reactome:R-RNO-74217	-	-	-	caution:"The participant EBI-349571(P68370) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919386(Q7TP47) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920972(Q5XIP9) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-916419(P11980) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919578(Q8R491) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920554(Q5U3Z7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920647(Q5U2X8) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920585(Q7TP24) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-779677(P05426) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-915744(P02454) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|agonist:Insulin was shown to increase or decrease GLUT4 protein interactions in specific cases.|comment:"Insulin decreased GLUT4 interactions with the following proteins: Q9ER30 (Sarcosin), P09527 (Rab-7), O88960 (N-ethylmaleimide sensitive), P09456 (PKA I regulatory subunit), P27881 (Hexokinase type II), P07872 (Acyl-coenzyme A oxidase), Q6DGF1 (Isocitrate dehydrogenase), Q9EQX9 (Ubiquitin-conjugating), Q63446 (Polyubiquitin), P24268 (Cathepsin D), Q91XW0 (Heat shock protein 86), Q5FVH0 (unknown), P58405 (Striatin 3), Q62667 (Major vault protein), Q66H50 (unknown), Q09167 (splicing factor), Q9JHU5 (Arfaptin 1)."|comment:"Insulin increased GLUT4 interaction with the following proteins:Q9Z1P2 (R-actinin-1), P45592 (Cofilin), Q9QXQ0 (R-actinin-4), P26473 (ADP-ribosylation factor), P26437 (ADP-ribosylation factor),   Q7TNP1 (Basigin 2), Q6P6R2 (Dihydrolipoamide dehydrogenase),   P04797 (GAPDH), Q63081 (Protein disulfide isomerase), P29457 (47 kDa heat shock protein), Q9R1J8 (Leprecan), O88638 (Putative eps protein),   Q64375 (Synaptonemal complex)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:NDPK - Interactions involving proteins containing InterPro domain IPR001564, Nucleoside diphosphate kinase, core.	taxid:10116(rat-l6)|taxid:10116(Rattus norvegicus)	-	2006/02/15	2021/11/30	rogid:PbFY2lfrty8yw40Jq7ShR7xfuV410116	rogid:/h1SMU4kU40Clh5OKdH/2I2ORVU10116	intact-crc:44F3A2176D02515F|rigid:9RVm0UBcqQF4k06RGKO89Bg16Q8	false	myc tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P19357	uniprotkb:P36202	intact:EBI-915426|uniprotkb:P97900|ensembl:ENSRNOP00000023256	intact:EBI-917380	psi-mi:glut4_rat(display_long)|uniprotkb:Glucose transporter type 4, insulin-responsive(gene name synonym)|uniprotkb:Slc2a4(gene name)|psi-mi:Slc2a4(display_short)|uniprotkb:Glut4(gene name synonym)	psi-mi:pdli4_rat(display_long)|uniprotkb:LIM protein RIL(gene name synonym)|uniprotkb:Reversion-induced LIM protein(gene name synonym)|uniprotkb:H-REV18(gene name synonym)|uniprotkb:RIT-18(gene name synonym)|uniprotkb:Pdlim4(gene name)|psi-mi:Pdlim4(display_short)|uniprotkb:Ril(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Foster et al. (2006)	pubmed:16396496|mint:MINT-5218203	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-921030	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2711|refseq:NP_036883.1|refseq:XP_006246658.1|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007611"(learning or memory)|go:"GO:0007614"(short-term memory)|go:"GO:0007616"(long-term memory)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010021"(amylopectin biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031550"(positive regulation of brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044381"(glucose import in response to insulin stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046323"(glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0098694"(regulation of synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0098793"(presynapse)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002441("Glucose transporter, type 4 (GLUT4)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-189200|ensembl:ENSRNOG00000017226(gene)|ensembl:ENSRNOT00000023256(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)	rgd:3575|refseq:NP_058758.1|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001781(Zinc finger, LIM-type)|interpro:IPR031847|interpro:IPR036034|go:"GO:0001725"(stress fiber)|go:"GO:0003779"(actin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005912"(adherens junction)|go:"GO:0007507"(heart development)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030018"(Z disc)|go:"GO:0030027"(lamellipodium)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0031901"(early endosome membrane)|go:"GO:0031905"(early endosome lumen)|go:"GO:0031941"(filamentous actin)|go:"GO:0034777"(recycling endosome lumen)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042805"(actinin binding)|go:"GO:0043197"(dendritic spine)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0046872"(metal ion binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051371"(muscle alpha-actinin binding)|go:"GO:0051393"(alpha-actinin binding)|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0055038"(recycling endosome membrane)|go:"GO:0061061"(muscle structure development)|go:"GO:0098976"(excitatory chemical synaptic transmission)	-	-	-	caution:"The participant EBI-349571(P68370) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919386(Q7TP47) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920972(Q5XIP9) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-916419(P11980) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919578(Q8R491) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920554(Q5U3Z7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920647(Q5U2X8) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920585(Q7TP24) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-779677(P05426) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-915744(P02454) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|agonist:Insulin was shown to increase or decrease GLUT4 protein interactions in specific cases.|comment:"Insulin decreased GLUT4 interactions with the following proteins: Q9ER30 (Sarcosin), P09527 (Rab-7), O88960 (N-ethylmaleimide sensitive), P09456 (PKA I regulatory subunit), P27881 (Hexokinase type II), P07872 (Acyl-coenzyme A oxidase), Q6DGF1 (Isocitrate dehydrogenase), Q9EQX9 (Ubiquitin-conjugating), Q63446 (Polyubiquitin), P24268 (Cathepsin D), Q91XW0 (Heat shock protein 86), Q5FVH0 (unknown), P58405 (Striatin 3), Q62667 (Major vault protein), Q66H50 (unknown), Q09167 (splicing factor), Q9JHU5 (Arfaptin 1)."|comment:"Insulin increased GLUT4 interaction with the following proteins:Q9Z1P2 (R-actinin-1), P45592 (Cofilin), Q9QXQ0 (R-actinin-4), P26473 (ADP-ribosylation factor), P26437 (ADP-ribosylation factor),   Q7TNP1 (Basigin 2), Q6P6R2 (Dihydrolipoamide dehydrogenase),   P04797 (GAPDH), Q63081 (Protein disulfide isomerase), P29457 (47 kDa heat shock protein), Q9R1J8 (Leprecan), O88638 (Putative eps protein),   Q64375 (Synaptonemal complex)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:NDPK - Interactions involving proteins containing InterPro domain IPR001564, Nucleoside diphosphate kinase, core.	taxid:10116(rat-l6)|taxid:10116(Rattus norvegicus)	-	2006/02/15	2021/11/30	rogid:PbFY2lfrty8yw40Jq7ShR7xfuV410116	rogid:W8jelqk9Pwc8ykEl/Rrfg5qCH6s10116	intact-crc:44F3A2176D02515F|rigid:9RVm0UBcqQF4k06RGKO89Bg16Q8	false	myc tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P19357	uniprotkb:P35704	intact:EBI-915426|uniprotkb:P97900|ensembl:ENSRNOP00000023256	intact:EBI-917371|uniprotkb:Q6PDV3	psi-mi:glut4_rat(display_long)|uniprotkb:Glucose transporter type 4, insulin-responsive(gene name synonym)|uniprotkb:Slc2a4(gene name)|psi-mi:Slc2a4(display_short)|uniprotkb:Glut4(gene name synonym)	psi-mi:prdx2_rat(display_long)|uniprotkb:Thioredoxin peroxidase 1(gene name synonym)|uniprotkb:Thioredoxin-dependent peroxide reductase 1(gene name synonym)|uniprotkb:Thiol-specific antioxidant protein(gene name synonym)|uniprotkb:Prdx2(gene name)|psi-mi:Prdx2(display_short)|uniprotkb:Tdpx1(gene name synonym)|uniprotkb:Thioredoxin-dependent peroxiredoxin 2(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Foster et al. (2006)	pubmed:16396496|mint:MINT-5218203	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-921030	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2711|refseq:NP_036883.1|refseq:XP_006246658.1|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007611"(learning or memory)|go:"GO:0007614"(short-term memory)|go:"GO:0007616"(long-term memory)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010021"(amylopectin biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031550"(positive regulation of brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044381"(glucose import in response to insulin stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046323"(glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0098694"(regulation of synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0098793"(presynapse)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002441("Glucose transporter, type 4 (GLUT4)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-189200|ensembl:ENSRNOG00000017226(gene)|ensembl:ENSRNOT00000023256(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)	rgd:3838|refseq:NP_058865.1|interpro:IPR000866(Alkyl hydroperoxide reductase/ Thiol specific antioxidant/ Mal allergen)|interpro:IPR024706|interpro:IPR019479|mint:P35704|interpro:IPR013766(Thioredoxin domain)|refseq:XP_006255306.1|interpro:IPR036249|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0002357"(defense response to tumor cell)|go:"GO:0002536"(respiratory burst involved in inflammatory response)|go:"GO:0005829"(cytosol)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0008379"(thioredoxin peroxidase activity)|go:"GO:0010310"(regulation of hydrogen peroxide metabolic process)|go:"GO:0016209"(antioxidant activity)|go:"GO:0019430"(removal of superoxide radicals)|go:"GO:0030194"(positive regulation of blood coagulation)|go:"GO:0031665"(negative regulation of lipopolysaccharide-mediated signaling pathway)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0042098"(T cell proliferation)|go:"GO:0042743"(hydrogen peroxide metabolic process)|go:"GO:0042744"(hydrogen peroxide catabolic process)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0045321"(leukocyte activation)|go:"GO:0045454"(cell redox homeostasis)|go:"GO:0045581"(negative regulation of T cell differentiation)|go:"GO:0048538"(thymus development)|go:"GO:0048872"(homeostasis of number of cells)|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway)|go:"GO:2001240"(negative regulation of extrinsic apoptotic signaling pathway in absence of ligand)|reactome:R-RNO-3299685|reactome:R-RNO-5628897	-	-	-	caution:"The participant EBI-349571(P68370) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919386(Q7TP47) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920972(Q5XIP9) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-916419(P11980) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919578(Q8R491) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920554(Q5U3Z7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920647(Q5U2X8) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920585(Q7TP24) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-779677(P05426) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-915744(P02454) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|agonist:Insulin was shown to increase or decrease GLUT4 protein interactions in specific cases.|comment:"Insulin decreased GLUT4 interactions with the following proteins: Q9ER30 (Sarcosin), P09527 (Rab-7), O88960 (N-ethylmaleimide sensitive), P09456 (PKA I regulatory subunit), P27881 (Hexokinase type II), P07872 (Acyl-coenzyme A oxidase), Q6DGF1 (Isocitrate dehydrogenase), Q9EQX9 (Ubiquitin-conjugating), Q63446 (Polyubiquitin), P24268 (Cathepsin D), Q91XW0 (Heat shock protein 86), Q5FVH0 (unknown), P58405 (Striatin 3), Q62667 (Major vault protein), Q66H50 (unknown), Q09167 (splicing factor), Q9JHU5 (Arfaptin 1)."|comment:"Insulin increased GLUT4 interaction with the following proteins:Q9Z1P2 (R-actinin-1), P45592 (Cofilin), Q9QXQ0 (R-actinin-4), P26473 (ADP-ribosylation factor), P26437 (ADP-ribosylation factor),   Q7TNP1 (Basigin 2), Q6P6R2 (Dihydrolipoamide dehydrogenase),   P04797 (GAPDH), Q63081 (Protein disulfide isomerase), P29457 (47 kDa heat shock protein), Q9R1J8 (Leprecan), O88638 (Putative eps protein),   Q64375 (Synaptonemal complex)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:NDPK - Interactions involving proteins containing InterPro domain IPR001564, Nucleoside diphosphate kinase, core.	taxid:10116(rat-l6)|taxid:10116(Rattus norvegicus)	-	2006/02/15	2021/11/30	rogid:PbFY2lfrty8yw40Jq7ShR7xfuV410116	rogid:pAorkTLST5+rViOjvDlhw2edzQE10116	intact-crc:44F3A2176D02515F|rigid:9RVm0UBcqQF4k06RGKO89Bg16Q8	false	myc tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P19357	uniprotkb:P35565	intact:EBI-915426|uniprotkb:P97900|ensembl:ENSRNOP00000023256	intact:EBI-917363|ensembl:ENSRNOP00000040859	psi-mi:glut4_rat(display_long)|uniprotkb:Glucose transporter type 4, insulin-responsive(gene name synonym)|uniprotkb:Slc2a4(gene name)|psi-mi:Slc2a4(display_short)|uniprotkb:Glut4(gene name synonym)	psi-mi:calx_rat(display_long)|uniprotkb:Canx(gene name)|psi-mi:Canx(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Foster et al. (2006)	pubmed:16396496|mint:MINT-5218203	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-921030	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2711|refseq:NP_036883.1|refseq:XP_006246658.1|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007611"(learning or memory)|go:"GO:0007614"(short-term memory)|go:"GO:0007616"(long-term memory)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010021"(amylopectin biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031550"(positive regulation of brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044381"(glucose import in response to insulin stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046323"(glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0098694"(regulation of synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0098793"(presynapse)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002441("Glucose transporter, type 4 (GLUT4)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-189200|ensembl:ENSRNOG00000017226(gene)|ensembl:ENSRNOT00000023256(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)	rgd:2266|refseq:NP_742005.1|refseq:XP_008765901.1|refseq:XP_008765902.1|ensembl:ENSRNOG00000003343(gene)|ensembl:ENSRNOT00000049942(transcript)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005790"(smooth endoplasmic reticulum)|go:"GO:0005840"(ribosome)|go:"GO:0006457"(protein folding)|go:"GO:0007568"(aging)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030246"(carbohydrate binding)|go:"GO:0030424"(axon)|go:"GO:0030968"(endoplasmic reticulum unfolded protein response)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034185"(apolipoprotein binding)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0042470"(melanosome)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043197"(dendritic spine)|go:"GO:0044233"(mitochondria-associated endoplasmic reticulum membrane)|go:"GO:0044322"(endoplasmic reticulum quality control compartment)|go:"GO:0048488"(synaptic vesicle endocytosis)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0072583"(clathrin-dependent endocytosis)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099055"(integral component of postsynaptic membrane)|go:"GO:0099059"(integral component of presynaptic active zone membrane)|interpro:IPR001580(Calreticulin/calnexin)|interpro:IPR009033(Calreticulin/calnexin, P)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR018124|mint:P35565|reactome:R-RNO-2132295|reactome:R-RNO-901042|reactome:R-RNO-9020956|reactome:R-RNO-983170	-	-	-	caution:"The participant EBI-349571(P68370) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919386(Q7TP47) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920972(Q5XIP9) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-916419(P11980) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919578(Q8R491) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920554(Q5U3Z7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920647(Q5U2X8) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920585(Q7TP24) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-779677(P05426) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-915744(P02454) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|agonist:Insulin was shown to increase or decrease GLUT4 protein interactions in specific cases.|comment:"Insulin decreased GLUT4 interactions with the following proteins: Q9ER30 (Sarcosin), P09527 (Rab-7), O88960 (N-ethylmaleimide sensitive), P09456 (PKA I regulatory subunit), P27881 (Hexokinase type II), P07872 (Acyl-coenzyme A oxidase), Q6DGF1 (Isocitrate dehydrogenase), Q9EQX9 (Ubiquitin-conjugating), Q63446 (Polyubiquitin), P24268 (Cathepsin D), Q91XW0 (Heat shock protein 86), Q5FVH0 (unknown), P58405 (Striatin 3), Q62667 (Major vault protein), Q66H50 (unknown), Q09167 (splicing factor), Q9JHU5 (Arfaptin 1)."|comment:"Insulin increased GLUT4 interaction with the following proteins:Q9Z1P2 (R-actinin-1), P45592 (Cofilin), Q9QXQ0 (R-actinin-4), P26473 (ADP-ribosylation factor), P26437 (ADP-ribosylation factor),   Q7TNP1 (Basigin 2), Q6P6R2 (Dihydrolipoamide dehydrogenase),   P04797 (GAPDH), Q63081 (Protein disulfide isomerase), P29457 (47 kDa heat shock protein), Q9R1J8 (Leprecan), O88638 (Putative eps protein),   Q64375 (Synaptonemal complex)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:NDPK - Interactions involving proteins containing InterPro domain IPR001564, Nucleoside diphosphate kinase, core.	taxid:10116(rat-l6)|taxid:10116(Rattus norvegicus)	-	2006/02/15	2021/11/30	rogid:PbFY2lfrty8yw40Jq7ShR7xfuV410116	rogid:OA7gJ6oMBN6zraU38Xg856XebR810116	intact-crc:44F3A2176D02515F|rigid:9RVm0UBcqQF4k06RGKO89Bg16Q8	false	myc tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P19357	uniprotkb:P35435	intact:EBI-915426|uniprotkb:P97900|ensembl:ENSRNOP00000023256	intact:EBI-917355	psi-mi:glut4_rat(display_long)|uniprotkb:Glucose transporter type 4, insulin-responsive(gene name synonym)|uniprotkb:Slc2a4(gene name)|psi-mi:Slc2a4(display_short)|uniprotkb:Glut4(gene name synonym)	psi-mi:atpg_rat(display_long)|uniprotkb:Atp5f1c(gene name)|psi-mi:Atp5f1c(display_short)|uniprotkb:ATP synthase F1 subunit gamma(gene name synonym)|uniprotkb:Atp5c(gene name synonym)|uniprotkb:Atp5c1(gene name synonym)|uniprotkb:F-ATPase gamma subunit(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Foster et al. (2006)	pubmed:16396496|mint:MINT-5218203	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-921030	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2711|refseq:NP_036883.1|refseq:XP_006246658.1|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007611"(learning or memory)|go:"GO:0007614"(short-term memory)|go:"GO:0007616"(long-term memory)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010021"(amylopectin biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031550"(positive regulation of brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044381"(glucose import in response to insulin stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046323"(glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0098694"(regulation of synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0098793"(presynapse)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002441("Glucose transporter, type 4 (GLUT4)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-189200|ensembl:ENSRNOG00000017226(gene)|ensembl:ENSRNOT00000023256(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)	rgd:620011|interpro:IPR000131(ATPase, F1 complex, gamma subunit)|interpro:IPR023632|mint:P35435|interpro:IPR035968|go:"GO:0000275"("mitochondrial proton-transporting ATP synthase complex, catalytic sector F(1)")|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005753"(mitochondrial proton-transporting ATP synthase complex)|go:"GO:0015986"(ATP synthesis coupled proton transport)|go:"GO:0042776"(mitochondrial ATP synthesis coupled proton transport)|go:"GO:0045261"("proton-transporting ATP synthase complex, catalytic core F(1)")|go:"GO:0046034"(ATP metabolic process)|go:"GO:0046933"(proton-transporting ATP synthase activity, rotational mechanism)|go:"GO:0071732"(cellular response to nitric oxide)|rcsb pdb:1MAB|rcsb pdb:2F43|reactome:R-RNO-163210|reactome:R-RNO-8949613	-	-	-	caution:"The participant EBI-349571(P68370) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919386(Q7TP47) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920972(Q5XIP9) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-916419(P11980) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919578(Q8R491) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920554(Q5U3Z7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920647(Q5U2X8) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920585(Q7TP24) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-779677(P05426) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-915744(P02454) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|agonist:Insulin was shown to increase or decrease GLUT4 protein interactions in specific cases.|comment:"Insulin decreased GLUT4 interactions with the following proteins: Q9ER30 (Sarcosin), P09527 (Rab-7), O88960 (N-ethylmaleimide sensitive), P09456 (PKA I regulatory subunit), P27881 (Hexokinase type II), P07872 (Acyl-coenzyme A oxidase), Q6DGF1 (Isocitrate dehydrogenase), Q9EQX9 (Ubiquitin-conjugating), Q63446 (Polyubiquitin), P24268 (Cathepsin D), Q91XW0 (Heat shock protein 86), Q5FVH0 (unknown), P58405 (Striatin 3), Q62667 (Major vault protein), Q66H50 (unknown), Q09167 (splicing factor), Q9JHU5 (Arfaptin 1)."|comment:"Insulin increased GLUT4 interaction with the following proteins:Q9Z1P2 (R-actinin-1), P45592 (Cofilin), Q9QXQ0 (R-actinin-4), P26473 (ADP-ribosylation factor), P26437 (ADP-ribosylation factor),   Q7TNP1 (Basigin 2), Q6P6R2 (Dihydrolipoamide dehydrogenase),   P04797 (GAPDH), Q63081 (Protein disulfide isomerase), P29457 (47 kDa heat shock protein), Q9R1J8 (Leprecan), O88638 (Putative eps protein),   Q64375 (Synaptonemal complex)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:NDPK - Interactions involving proteins containing InterPro domain IPR001564, Nucleoside diphosphate kinase, core.	taxid:10116(rat-l6)|taxid:10116(Rattus norvegicus)	-	2006/02/15	2021/11/30	rogid:PbFY2lfrty8yw40Jq7ShR7xfuV410116	rogid:py9RCXV2/aoMy8UslZteKeJAdak10116	intact-crc:44F3A2176D02515F|rigid:9RVm0UBcqQF4k06RGKO89Bg16Q8	false	myc tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P19357	uniprotkb:P35434	intact:EBI-915426|uniprotkb:P97900|ensembl:ENSRNOP00000023256	intact:EBI-917347	psi-mi:glut4_rat(display_long)|uniprotkb:Glucose transporter type 4, insulin-responsive(gene name synonym)|uniprotkb:Slc2a4(gene name)|psi-mi:Slc2a4(display_short)|uniprotkb:Glut4(gene name synonym)	psi-mi:atpd_rat(display_long)|uniprotkb:ATP synthase F1 subunit delta(gene name synonym)|uniprotkb:Atp5f1d(gene name)|psi-mi:Atp5f1d(display_short)|uniprotkb:Atp5d(gene name synonym)|uniprotkb:F-ATPase delta subunit(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Foster et al. (2006)	pubmed:16396496|mint:MINT-5218203	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-921030	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2711|refseq:NP_036883.1|refseq:XP_006246658.1|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007611"(learning or memory)|go:"GO:0007614"(short-term memory)|go:"GO:0007616"(long-term memory)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010021"(amylopectin biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031550"(positive regulation of brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044381"(glucose import in response to insulin stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046323"(glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0098694"(regulation of synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0098793"(presynapse)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002441("Glucose transporter, type 4 (GLUT4)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-189200|ensembl:ENSRNOG00000017226(gene)|ensembl:ENSRNOT00000023256(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)	rgd:621372|refseq:NP_620806.1|interpro:IPR001469(ATPase, F1 complex, delta/epsilon subunit)|interpro:IPR020546|mint:P35434|interpro:IPR036771|interpro:IPR036794|go:"GO:0000275"("mitochondrial proton-transporting ATP synthase complex, catalytic sector F(1)")|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005753"(mitochondrial proton-transporting ATP synthase complex)|go:"GO:0006754"(ATP biosynthetic process)|go:"GO:0009060"(aerobic respiration)|go:"GO:0015986"(ATP synthesis coupled proton transport)|go:"GO:0033615"(mitochondrial proton-transporting ATP synthase complex assembly)|go:"GO:0042776"(mitochondrial ATP synthesis coupled proton transport)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045259"(proton-transporting ATP synthase complex)|go:"GO:0045261"("proton-transporting ATP synthase complex, catalytic core F(1)")|go:"GO:0046034"(ATP metabolic process)|go:"GO:0046933"(proton-transporting ATP synthase activity, rotational mechanism)|go:"GO:1904638"(response to resveratrol)|reactome:R-RNO-163210|reactome:R-RNO-8949613	-	-	-	caution:"The participant EBI-349571(P68370) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919386(Q7TP47) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920972(Q5XIP9) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-916419(P11980) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919578(Q8R491) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920554(Q5U3Z7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920647(Q5U2X8) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920585(Q7TP24) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-779677(P05426) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-915744(P02454) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|agonist:Insulin was shown to increase or decrease GLUT4 protein interactions in specific cases.|comment:"Insulin decreased GLUT4 interactions with the following proteins: Q9ER30 (Sarcosin), P09527 (Rab-7), O88960 (N-ethylmaleimide sensitive), P09456 (PKA I regulatory subunit), P27881 (Hexokinase type II), P07872 (Acyl-coenzyme A oxidase), Q6DGF1 (Isocitrate dehydrogenase), Q9EQX9 (Ubiquitin-conjugating), Q63446 (Polyubiquitin), P24268 (Cathepsin D), Q91XW0 (Heat shock protein 86), Q5FVH0 (unknown), P58405 (Striatin 3), Q62667 (Major vault protein), Q66H50 (unknown), Q09167 (splicing factor), Q9JHU5 (Arfaptin 1)."|comment:"Insulin increased GLUT4 interaction with the following proteins:Q9Z1P2 (R-actinin-1), P45592 (Cofilin), Q9QXQ0 (R-actinin-4), P26473 (ADP-ribosylation factor), P26437 (ADP-ribosylation factor),   Q7TNP1 (Basigin 2), Q6P6R2 (Dihydrolipoamide dehydrogenase),   P04797 (GAPDH), Q63081 (Protein disulfide isomerase), P29457 (47 kDa heat shock protein), Q9R1J8 (Leprecan), O88638 (Putative eps protein),   Q64375 (Synaptonemal complex)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:NDPK - Interactions involving proteins containing InterPro domain IPR001564, Nucleoside diphosphate kinase, core.	taxid:10116(rat-l6)|taxid:10116(Rattus norvegicus)	-	2006/02/15	2021/11/30	rogid:PbFY2lfrty8yw40Jq7ShR7xfuV410116	rogid:Lop70nPmqktZ1JdbvWEXr7EgNnk10116	intact-crc:44F3A2176D02515F|rigid:9RVm0UBcqQF4k06RGKO89Bg16Q8	false	myc tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P19357	uniprotkb:P35427	intact:EBI-915426|uniprotkb:P97900|ensembl:ENSRNOP00000023256	intact:EBI-917340	psi-mi:glut4_rat(display_long)|uniprotkb:Glucose transporter type 4, insulin-responsive(gene name synonym)|uniprotkb:Slc2a4(gene name)|psi-mi:Slc2a4(display_short)|uniprotkb:Glut4(gene name synonym)	psi-mi:rl13a_rat(display_long)|uniprotkb:Rpl13a(gene name)|psi-mi:Rpl13a(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Foster et al. (2006)	pubmed:16396496|mint:MINT-5218203	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-921030	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2711|refseq:NP_036883.1|refseq:XP_006246658.1|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007611"(learning or memory)|go:"GO:0007614"(short-term memory)|go:"GO:0007616"(long-term memory)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010021"(amylopectin biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031550"(positive regulation of brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044381"(glucose import in response to insulin stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046323"(glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0098694"(regulation of synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0098793"(presynapse)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002441("Glucose transporter, type 4 (GLUT4)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-189200|ensembl:ENSRNOG00000017226(gene)|ensembl:ENSRNOT00000023256(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)	rgd:628697|interpro:IPR005822(Ribosomal protein L13)|interpro:IPR023563|interpro:IPR005755(Ribosomal protein L13, eukaryotic/archaeal)|reactome:R-RNO-156827|reactome:R-RNO-1799339|reactome:R-RNO-6791226|reactome:R-RNO-72689|reactome:R-RNO-72706|reactome:R-RNO-975956|reactome:R-RNO-975957|interpro:IPR036899|go:"GO:0003729"(mRNA binding)|go:"GO:0003735"(structural constituent of ribosome)|go:"GO:0005840"(ribosome)|go:"GO:0006412"(translation)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0022625"(cytosolic large ribosomal subunit)|go:"GO:0022626"(cytosolic ribosome)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0042592"(homeostatic process)|go:"GO:0048246"(macrophage chemotaxis)|go:"GO:0060425"(lung morphogenesis)|go:"GO:0071320"(cellular response to cAMP)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071480"(cellular response to gamma radiation)|go:"GO:0071493"(cellular response to UV-B)|go:"GO:0097452"(GAIT complex)|go:"GO:1901194"(negative regulation of formation of translation preinitiation complex)|go:"GO:1990904"(ribonucleoprotein complex)	-	-	-	caution:"The participant EBI-349571(P68370) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919386(Q7TP47) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920972(Q5XIP9) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-916419(P11980) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919578(Q8R491) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920554(Q5U3Z7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920647(Q5U2X8) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920585(Q7TP24) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-779677(P05426) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-915744(P02454) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|agonist:Insulin was shown to increase or decrease GLUT4 protein interactions in specific cases.|comment:"Insulin decreased GLUT4 interactions with the following proteins: Q9ER30 (Sarcosin), P09527 (Rab-7), O88960 (N-ethylmaleimide sensitive), P09456 (PKA I regulatory subunit), P27881 (Hexokinase type II), P07872 (Acyl-coenzyme A oxidase), Q6DGF1 (Isocitrate dehydrogenase), Q9EQX9 (Ubiquitin-conjugating), Q63446 (Polyubiquitin), P24268 (Cathepsin D), Q91XW0 (Heat shock protein 86), Q5FVH0 (unknown), P58405 (Striatin 3), Q62667 (Major vault protein), Q66H50 (unknown), Q09167 (splicing factor), Q9JHU5 (Arfaptin 1)."|comment:"Insulin increased GLUT4 interaction with the following proteins:Q9Z1P2 (R-actinin-1), P45592 (Cofilin), Q9QXQ0 (R-actinin-4), P26473 (ADP-ribosylation factor), P26437 (ADP-ribosylation factor),   Q7TNP1 (Basigin 2), Q6P6R2 (Dihydrolipoamide dehydrogenase),   P04797 (GAPDH), Q63081 (Protein disulfide isomerase), P29457 (47 kDa heat shock protein), Q9R1J8 (Leprecan), O88638 (Putative eps protein),   Q64375 (Synaptonemal complex)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:NDPK - Interactions involving proteins containing InterPro domain IPR001564, Nucleoside diphosphate kinase, core.	taxid:10116(rat-l6)|taxid:10116(Rattus norvegicus)	-	2006/02/15	2021/11/30	rogid:PbFY2lfrty8yw40Jq7ShR7xfuV410116	rogid:y8MhHySZoTMFrxR5mFmT2rIDKRk10116	intact-crc:44F3A2176D02515F|rigid:9RVm0UBcqQF4k06RGKO89Bg16Q8	false	myc tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P19357	uniprotkb:P35286	intact:EBI-915426|uniprotkb:P97900|ensembl:ENSRNOP00000023256	intact:EBI-917332|uniprotkb:Q8K3X5|ensembl:ENSRNOP00000071741	psi-mi:glut4_rat(display_long)|uniprotkb:Glucose transporter type 4, insulin-responsive(gene name synonym)|uniprotkb:Slc2a4(gene name)|psi-mi:Slc2a4(display_short)|uniprotkb:Glut4(gene name synonym)	psi-mi:rab13_rat(display_long)|uniprotkb:Rab13(gene name)|psi-mi:Rab13(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Foster et al. (2006)	pubmed:16396496|mint:MINT-5218203	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-921030	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2711|refseq:NP_036883.1|refseq:XP_006246658.1|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007611"(learning or memory)|go:"GO:0007614"(short-term memory)|go:"GO:0007616"(long-term memory)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010021"(amylopectin biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031550"(positive regulation of brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044381"(glucose import in response to insulin stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046323"(glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0098694"(regulation of synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0098793"(presynapse)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002441("Glucose transporter, type 4 (GLUT4)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-189200|ensembl:ENSRNOG00000017226(gene)|ensembl:ENSRNOT00000023256(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)	rgd:620880|refseq:NP_112354.1|ensembl:ENSRNOG00000016733(gene)|ensembl:ENSRNOT00000092112(transcript)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005768"(endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0006904"(vesicle docking involved in exocytosis)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0009306"(protein secretion)|go:"GO:0010737"(protein kinase A signaling)|go:"GO:0016197"(endosomal transport)|go:"GO:0016328"(lateral plasma membrane)|go:"GO:0017157"(regulation of exocytosis)|go:"GO:0030027"(lamellipodium)|go:"GO:0030139"(endocytic vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0030866"(cortical actin cytoskeleton organization)|go:"GO:0031175"(neuron projection development)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0032456"(endocytic recycling)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0034236"(protein kinase A catalytic subunit binding)|go:"GO:0035767"(endothelial cell chemotaxis)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043005"(neuron projection)|go:"GO:0044795"(trans-Golgi network to recycling endosome transport)|go:"GO:0046326"(positive regulation of glucose import)|go:"GO:0048210"(Golgi vesicle fusion to target membrane)|go:"GO:0055037"(recycling endosome)|go:"GO:0055038"(recycling endosome membrane)|go:"GO:0070830"(bicellular tight junction assembly)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0097368"(establishment of Sertoli cell barrier)|go:"GO:1902463"(protein localization to cell leading edge)|interpro:IPR001806(Ras GTPase)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR027417|mint:P35286|reactome:R-RNO-8873719|reactome:R-RNO-8876198	-	-	-	caution:"The participant EBI-349571(P68370) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919386(Q7TP47) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920972(Q5XIP9) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-916419(P11980) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919578(Q8R491) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920554(Q5U3Z7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920647(Q5U2X8) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920585(Q7TP24) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-779677(P05426) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-915744(P02454) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|agonist:Insulin was shown to increase or decrease GLUT4 protein interactions in specific cases.|comment:"Insulin decreased GLUT4 interactions with the following proteins: Q9ER30 (Sarcosin), P09527 (Rab-7), O88960 (N-ethylmaleimide sensitive), P09456 (PKA I regulatory subunit), P27881 (Hexokinase type II), P07872 (Acyl-coenzyme A oxidase), Q6DGF1 (Isocitrate dehydrogenase), Q9EQX9 (Ubiquitin-conjugating), Q63446 (Polyubiquitin), P24268 (Cathepsin D), Q91XW0 (Heat shock protein 86), Q5FVH0 (unknown), P58405 (Striatin 3), Q62667 (Major vault protein), Q66H50 (unknown), Q09167 (splicing factor), Q9JHU5 (Arfaptin 1)."|comment:"Insulin increased GLUT4 interaction with the following proteins:Q9Z1P2 (R-actinin-1), P45592 (Cofilin), Q9QXQ0 (R-actinin-4), P26473 (ADP-ribosylation factor), P26437 (ADP-ribosylation factor),   Q7TNP1 (Basigin 2), Q6P6R2 (Dihydrolipoamide dehydrogenase),   P04797 (GAPDH), Q63081 (Protein disulfide isomerase), P29457 (47 kDa heat shock protein), Q9R1J8 (Leprecan), O88638 (Putative eps protein),   Q64375 (Synaptonemal complex)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:NDPK - Interactions involving proteins containing InterPro domain IPR001564, Nucleoside diphosphate kinase, core.	taxid:10116(rat-l6)|taxid:10116(Rattus norvegicus)	-	2006/02/15	2021/11/30	rogid:PbFY2lfrty8yw40Jq7ShR7xfuV410116	rogid:yh2vgPn/ofkCDA9teGK9WjmszwY10116	intact-crc:44F3A2176D02515F|rigid:9RVm0UBcqQF4k06RGKO89Bg16Q8	false	myc tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P19357	uniprotkb:P35284	intact:EBI-915426|uniprotkb:P97900|ensembl:ENSRNOP00000023256	intact:EBI-917322	psi-mi:glut4_rat(display_long)|uniprotkb:Glucose transporter type 4, insulin-responsive(gene name synonym)|uniprotkb:Slc2a4(gene name)|psi-mi:Slc2a4(display_short)|uniprotkb:Glut4(gene name synonym)	psi-mi:rab12_rat(display_long)|uniprotkb:Rab12(gene name)|psi-mi:Rab12(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Foster et al. (2006)	pubmed:16396496|mint:MINT-5218203	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-921030	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2711|refseq:NP_036883.1|refseq:XP_006246658.1|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007611"(learning or memory)|go:"GO:0007614"(short-term memory)|go:"GO:0007616"(long-term memory)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010021"(amylopectin biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031550"(positive regulation of brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044381"(glucose import in response to insulin stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046323"(glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0098694"(regulation of synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0098793"(presynapse)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002441("Glucose transporter, type 4 (GLUT4)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-189200|ensembl:ENSRNOG00000017226(gene)|ensembl:ENSRNOT00000023256(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)	rgd:3527|refseq:NP_037149.1|dip:DIP-36918N|reactome:R-RNO-8873719|reactome:R-RNO-8876198|go:"GO:0000139"(Golgi membrane)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005768"(endosome)|go:"GO:0005776"(autophagosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0006904"(vesicle docking involved in exocytosis)|go:"GO:0006914"(autophagy)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008333"(endosome to lysosome transport)|go:"GO:0009306"(protein secretion)|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0017157"(regulation of exocytosis)|go:"GO:0019003"(GDP binding)|go:"GO:0030141"(secretory granule)|go:"GO:0032482"(Rab protein signal transduction)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0044257"(cellular protein catabolic process)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0055037"(recycling endosome)|go:"GO:0055038"(recycling endosome membrane)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0072659"(protein localization to plasma membrane)|interpro:IPR001806(Ras GTPase)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR027417|interpro:IPR041830	-	-	-	caution:"The participant EBI-349571(P68370) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919386(Q7TP47) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920972(Q5XIP9) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-916419(P11980) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919578(Q8R491) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920554(Q5U3Z7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920647(Q5U2X8) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920585(Q7TP24) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-779677(P05426) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-915744(P02454) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|agonist:Insulin was shown to increase or decrease GLUT4 protein interactions in specific cases.|comment:"Insulin decreased GLUT4 interactions with the following proteins: Q9ER30 (Sarcosin), P09527 (Rab-7), O88960 (N-ethylmaleimide sensitive), P09456 (PKA I regulatory subunit), P27881 (Hexokinase type II), P07872 (Acyl-coenzyme A oxidase), Q6DGF1 (Isocitrate dehydrogenase), Q9EQX9 (Ubiquitin-conjugating), Q63446 (Polyubiquitin), P24268 (Cathepsin D), Q91XW0 (Heat shock protein 86), Q5FVH0 (unknown), P58405 (Striatin 3), Q62667 (Major vault protein), Q66H50 (unknown), Q09167 (splicing factor), Q9JHU5 (Arfaptin 1)."|comment:"Insulin increased GLUT4 interaction with the following proteins:Q9Z1P2 (R-actinin-1), P45592 (Cofilin), Q9QXQ0 (R-actinin-4), P26473 (ADP-ribosylation factor), P26437 (ADP-ribosylation factor),   Q7TNP1 (Basigin 2), Q6P6R2 (Dihydrolipoamide dehydrogenase),   P04797 (GAPDH), Q63081 (Protein disulfide isomerase), P29457 (47 kDa heat shock protein), Q9R1J8 (Leprecan), O88638 (Putative eps protein),   Q64375 (Synaptonemal complex)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:NDPK - Interactions involving proteins containing InterPro domain IPR001564, Nucleoside diphosphate kinase, core.	taxid:10116(rat-l6)|taxid:10116(Rattus norvegicus)	-	2006/02/15	2021/11/30	rogid:PbFY2lfrty8yw40Jq7ShR7xfuV410116	rogid:NngYHnA7ms8iRkLJCPqXTONuEFU10116	intact-crc:44F3A2176D02515F|rigid:9RVm0UBcqQF4k06RGKO89Bg16Q8	false	myc tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P19357	uniprotkb:P35281	intact:EBI-915426|uniprotkb:P97900|ensembl:ENSRNOP00000023256	intact:EBI-917314	psi-mi:glut4_rat(display_long)|uniprotkb:Glucose transporter type 4, insulin-responsive(gene name synonym)|uniprotkb:Slc2a4(gene name)|psi-mi:Slc2a4(display_short)|uniprotkb:Glut4(gene name synonym)	psi-mi:rab10_rat(display_long)|uniprotkb:Rab10(gene name)|psi-mi:Rab10(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Foster et al. (2006)	pubmed:16396496|mint:MINT-5218203	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-921030	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2711|refseq:NP_036883.1|refseq:XP_006246658.1|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007611"(learning or memory)|go:"GO:0007614"(short-term memory)|go:"GO:0007616"(long-term memory)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010021"(amylopectin biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031550"(positive regulation of brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044381"(glucose import in response to insulin stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046323"(glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0098694"(regulation of synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0098793"(presynapse)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002441("Glucose transporter, type 4 (GLUT4)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-189200|ensembl:ENSRNOG00000017226(gene)|ensembl:ENSRNOT00000023256(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)	interpro:IPR005225(Small GTP-binding protein)|interpro:IPR001806(Ras GTPase)|rgd:620879|interpro:IPR027417|mint:P35281|go:"GO:0003925"(G protein activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005768"(endosome)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005886"(plasma membrane)|go:"GO:0005929"(cilium)|go:"GO:0006893"(Golgi to plasma membrane transport)|go:"GO:0006904"(vesicle docking involved in exocytosis)|go:"GO:0007409"(axonogenesis)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0009306"(protein secretion)|go:"GO:0016020"(membrane)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0016197"(endosomal transport)|go:"GO:0017157"(regulation of exocytosis)|go:"GO:0019003"(GDP binding)|go:"GO:0019882"(antigen processing and presentation)|go:"GO:0030670"(phagocytic vesicle membrane)|go:"GO:0030859"(polarized epithelial cell differentiation)|go:"GO:0031489"(myosin V binding)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0043001"(Golgi to plasma membrane protein transport)|go:"GO:0045055"(regulated exocytosis)|go:"GO:0045200"(establishment of neuroblast polarity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051021"(GDP-dissociation inhibitor binding)|go:"GO:0055037"(recycling endosome)|go:"GO:0055038"(recycling endosome membrane)|go:"GO:0070382"(exocytic vesicle)|go:"GO:0071236"(cellular response to antibiotic)|go:"GO:0071782"(endoplasmic reticulum tubular network)|go:"GO:0071786"(endoplasmic reticulum tubular network organization)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0090150"(establishment of protein localization to membrane)|go:"GO:0097051"(establishment of protein localization to endoplasmic reticulum membrane)|go:"GO:0098993"(anchored component of synaptic vesicle membrane)|go:"GO:1903361"(protein localization to basolateral plasma membrane)|reactome:R-RNO-6798695|reactome:R-RNO-8873719|reactome:R-RNO-8876198	-	-	-	caution:"The participant EBI-349571(P68370) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919386(Q7TP47) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920972(Q5XIP9) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-916419(P11980) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919578(Q8R491) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920554(Q5U3Z7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920647(Q5U2X8) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920585(Q7TP24) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-779677(P05426) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-915744(P02454) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|agonist:Insulin was shown to increase or decrease GLUT4 protein interactions in specific cases.|comment:"Insulin decreased GLUT4 interactions with the following proteins: Q9ER30 (Sarcosin), P09527 (Rab-7), O88960 (N-ethylmaleimide sensitive), P09456 (PKA I regulatory subunit), P27881 (Hexokinase type II), P07872 (Acyl-coenzyme A oxidase), Q6DGF1 (Isocitrate dehydrogenase), Q9EQX9 (Ubiquitin-conjugating), Q63446 (Polyubiquitin), P24268 (Cathepsin D), Q91XW0 (Heat shock protein 86), Q5FVH0 (unknown), P58405 (Striatin 3), Q62667 (Major vault protein), Q66H50 (unknown), Q09167 (splicing factor), Q9JHU5 (Arfaptin 1)."|comment:"Insulin increased GLUT4 interaction with the following proteins:Q9Z1P2 (R-actinin-1), P45592 (Cofilin), Q9QXQ0 (R-actinin-4), P26473 (ADP-ribosylation factor), P26437 (ADP-ribosylation factor),   Q7TNP1 (Basigin 2), Q6P6R2 (Dihydrolipoamide dehydrogenase),   P04797 (GAPDH), Q63081 (Protein disulfide isomerase), P29457 (47 kDa heat shock protein), Q9R1J8 (Leprecan), O88638 (Putative eps protein),   Q64375 (Synaptonemal complex)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:NDPK - Interactions involving proteins containing InterPro domain IPR001564, Nucleoside diphosphate kinase, core.	taxid:10116(rat-l6)|taxid:10116(Rattus norvegicus)	-	2006/02/15	2021/11/30	rogid:PbFY2lfrty8yw40Jq7ShR7xfuV410116	rogid:QBab92qaS/E5P8CwghgaSofYfu410116	intact-crc:44F3A2176D02515F|rigid:9RVm0UBcqQF4k06RGKO89Bg16Q8	false	myc tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P19357	uniprotkb:P68255	intact:EBI-915426|uniprotkb:P97900|ensembl:ENSRNOP00000023256	intact:EBI-400680|uniprotkb:P35216|ensembl:ENSRNOP00000072011	psi-mi:glut4_rat(display_long)|uniprotkb:Glucose transporter type 4, insulin-responsive(gene name synonym)|uniprotkb:Slc2a4(gene name)|psi-mi:Slc2a4(display_short)|uniprotkb:Glut4(gene name synonym)	psi-mi:1433t_rat(display_long)|uniprotkb:Ywhaq(gene name)|psi-mi:Ywhaq(display_short)|uniprotkb:14-3-3 protein tau(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Foster et al. (2006)	pubmed:16396496|mint:MINT-5218203	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-921030	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2711|refseq:NP_036883.1|refseq:XP_006246658.1|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007611"(learning or memory)|go:"GO:0007614"(short-term memory)|go:"GO:0007616"(long-term memory)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010021"(amylopectin biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031550"(positive regulation of brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044381"(glucose import in response to insulin stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046323"(glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0098694"(regulation of synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0098793"(presynapse)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002441("Glucose transporter, type 4 (GLUT4)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-189200|ensembl:ENSRNOG00000017226(gene)|ensembl:ENSRNOT00000023256(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)	rgd:3979|refseq:NP_037185.1|ensembl:ENSRNOG00000051650(gene)|ensembl:ENSRNOT00000077786(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0006605"(protein targeting)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034766"(negative regulation of ion transmembrane transport)|go:"GO:0042802"(identical protein binding)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0045202"(synapse)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0071889"(14-3-3 protein binding)|interpro:IPR000308(14-3-3 protein)|interpro:IPR023409|interpro:IPR023410|interpro:IPR036815|interpro:IPR042584|mint:P68255|reactome:R-RNO-111447|reactome:R-RNO-5625740|reactome:R-RNO-5628897|reactome:R-RNO-75035|reactome:R-RNO-9614399|dip:DIP-947N	-	-	-	caution:"The participant EBI-349571(P68370) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919386(Q7TP47) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920972(Q5XIP9) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-916419(P11980) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919578(Q8R491) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920554(Q5U3Z7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920647(Q5U2X8) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920585(Q7TP24) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-779677(P05426) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-915744(P02454) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|agonist:Insulin was shown to increase or decrease GLUT4 protein interactions in specific cases.|comment:"Insulin decreased GLUT4 interactions with the following proteins: Q9ER30 (Sarcosin), P09527 (Rab-7), O88960 (N-ethylmaleimide sensitive), P09456 (PKA I regulatory subunit), P27881 (Hexokinase type II), P07872 (Acyl-coenzyme A oxidase), Q6DGF1 (Isocitrate dehydrogenase), Q9EQX9 (Ubiquitin-conjugating), Q63446 (Polyubiquitin), P24268 (Cathepsin D), Q91XW0 (Heat shock protein 86), Q5FVH0 (unknown), P58405 (Striatin 3), Q62667 (Major vault protein), Q66H50 (unknown), Q09167 (splicing factor), Q9JHU5 (Arfaptin 1)."|comment:"Insulin increased GLUT4 interaction with the following proteins:Q9Z1P2 (R-actinin-1), P45592 (Cofilin), Q9QXQ0 (R-actinin-4), P26473 (ADP-ribosylation factor), P26437 (ADP-ribosylation factor),   Q7TNP1 (Basigin 2), Q6P6R2 (Dihydrolipoamide dehydrogenase),   P04797 (GAPDH), Q63081 (Protein disulfide isomerase), P29457 (47 kDa heat shock protein), Q9R1J8 (Leprecan), O88638 (Putative eps protein),   Q64375 (Synaptonemal complex)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:NDPK - Interactions involving proteins containing InterPro domain IPR001564, Nucleoside diphosphate kinase, core.	taxid:10116(rat-l6)|taxid:10116(Rattus norvegicus)	-	2006/02/15	2021/11/30	rogid:PbFY2lfrty8yw40Jq7ShR7xfuV410116	rogid:l8bki6QJJEH5S5NIwQdm/MAYcc010116	intact-crc:44F3A2176D02515F|rigid:9RVm0UBcqQF4k06RGKO89Bg16Q8	false	myc tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P19357	uniprotkb:P63102	intact:EBI-915426|uniprotkb:P97900|ensembl:ENSRNOP00000023256	intact:EBI-354758|uniprotkb:P35215|uniprotkb:P70197|uniprotkb:P97286|uniprotkb:Q52KK1|uniprotkb:Q6IRF4|ensembl:ENSRNOP00000030885	psi-mi:glut4_rat(display_long)|uniprotkb:Glucose transporter type 4, insulin-responsive(gene name synonym)|uniprotkb:Slc2a4(gene name)|psi-mi:Slc2a4(display_short)|uniprotkb:Glut4(gene name synonym)	psi-mi:1433z_rat(display_long)|uniprotkb:Ywhaz(gene name)|psi-mi:Ywhaz(display_short)|uniprotkb:Msfs1(gene name synonym)|uniprotkb:Protein kinase C inhibitor protein 1(gene name synonym)|uniprotkb:Mitochondrial import stimulation factor S1 subunit(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Foster et al. (2006)	pubmed:16396496|mint:MINT-5218203	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-921030	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2711|refseq:NP_036883.1|refseq:XP_006246658.1|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007611"(learning or memory)|go:"GO:0007614"(short-term memory)|go:"GO:0007616"(long-term memory)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010021"(amylopectin biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031550"(positive regulation of brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044381"(glucose import in response to insulin stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046323"(glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0098694"(regulation of synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0098793"(presynapse)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002441("Glucose transporter, type 4 (GLUT4)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-189200|ensembl:ENSRNOG00000017226(gene)|ensembl:ENSRNOT00000023256(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)	rgd:3980|refseq:NP_037143.2|go:"GO:0019901"(protein kinase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030324"(lung development)|go:"GO:0031252"(cell leading edge)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035148"(tube formation)|go:"GO:0042470"(melanosome)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051683"(establishment of Golgi localization)|go:"GO:0070371"(ERK1 and ERK2 cascade)|go:"GO:0070372"(regulation of ERK1 and ERK2 cascade)|go:"GO:0090128"(regulation of synapse maturation)|go:"GO:0090168"(Golgi reassembly)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0140297"(DNA-binding transcription factor binding)|interpro:IPR000308(14-3-3 protein)|interpro:IPR023409|interpro:IPR023410|interpro:IPR036815|mint:P63102|reactome:R-RNO-111447|reactome:R-RNO-3769402|reactome:R-RNO-392517|reactome:R-RNO-430116|reactome:R-RNO-450604|reactome:R-RNO-512988|reactome:R-RNO-5625740|reactome:R-RNO-5628897|reactome:R-RNO-75035|reactome:R-RNO-9013700|reactome:R-RNO-9614399|refseq:XP_006241591.1|ensembl:ENSRNOG00000008195(gene)|ensembl:ENSRNOT00000035628(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0002553"(histamine secretion by mast cell)|go:"GO:0003016"(respiratory system process)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006605"(protein targeting)|go:"GO:0006626"(protein targeting to mitochondrion)|go:"GO:0007165"(signal transduction)|go:"GO:0008039"(synaptic target recognition)|go:"GO:0010941"(regulation of cell death)|go:"GO:0014069"(postsynaptic density)|dip:DIP-36916N	-	-	-	caution:"The participant EBI-349571(P68370) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919386(Q7TP47) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920972(Q5XIP9) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-916419(P11980) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919578(Q8R491) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920554(Q5U3Z7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920647(Q5U2X8) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920585(Q7TP24) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-779677(P05426) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-915744(P02454) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|agonist:Insulin was shown to increase or decrease GLUT4 protein interactions in specific cases.|comment:"Insulin decreased GLUT4 interactions with the following proteins: Q9ER30 (Sarcosin), P09527 (Rab-7), O88960 (N-ethylmaleimide sensitive), P09456 (PKA I regulatory subunit), P27881 (Hexokinase type II), P07872 (Acyl-coenzyme A oxidase), Q6DGF1 (Isocitrate dehydrogenase), Q9EQX9 (Ubiquitin-conjugating), Q63446 (Polyubiquitin), P24268 (Cathepsin D), Q91XW0 (Heat shock protein 86), Q5FVH0 (unknown), P58405 (Striatin 3), Q62667 (Major vault protein), Q66H50 (unknown), Q09167 (splicing factor), Q9JHU5 (Arfaptin 1)."|comment:"Insulin increased GLUT4 interaction with the following proteins:Q9Z1P2 (R-actinin-1), P45592 (Cofilin), Q9QXQ0 (R-actinin-4), P26473 (ADP-ribosylation factor), P26437 (ADP-ribosylation factor),   Q7TNP1 (Basigin 2), Q6P6R2 (Dihydrolipoamide dehydrogenase),   P04797 (GAPDH), Q63081 (Protein disulfide isomerase), P29457 (47 kDa heat shock protein), Q9R1J8 (Leprecan), O88638 (Putative eps protein),   Q64375 (Synaptonemal complex)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:NDPK - Interactions involving proteins containing InterPro domain IPR001564, Nucleoside diphosphate kinase, core.	taxid:10116(rat-l6)|taxid:10116(Rattus norvegicus)	-	2006/02/15	2021/11/30	rogid:PbFY2lfrty8yw40Jq7ShR7xfuV410116	rogid:v2N95HO8sYRWEg2gFtWiYajP1Sc10116	intact-crc:44F3A2176D02515F|rigid:9RVm0UBcqQF4k06RGKO89Bg16Q8	false	myc tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P19357	uniprotkb:P35213	intact:EBI-915426|uniprotkb:P97900|ensembl:ENSRNOP00000023256	intact:EBI-917309|ensembl:ENSRNOP00000016981	psi-mi:glut4_rat(display_long)|uniprotkb:Glucose transporter type 4, insulin-responsive(gene name synonym)|uniprotkb:Slc2a4(gene name)|psi-mi:Slc2a4(display_short)|uniprotkb:Glut4(gene name synonym)	psi-mi:1433b_rat(display_long)|uniprotkb:Protein kinase C inhibitor protein 1(gene name synonym)|uniprotkb:Prepronerve growth factor RNH-1(gene name synonym)|uniprotkb:Ywhab(gene name)|psi-mi:Ywhab(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Foster et al. (2006)	pubmed:16396496|mint:MINT-5218203	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-921030	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2711|refseq:NP_036883.1|refseq:XP_006246658.1|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007611"(learning or memory)|go:"GO:0007614"(short-term memory)|go:"GO:0007616"(long-term memory)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010021"(amylopectin biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031550"(positive regulation of brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044381"(glucose import in response to insulin stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046323"(glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0098694"(regulation of synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0098793"(presynapse)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002441("Glucose transporter, type 4 (GLUT4)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-189200|ensembl:ENSRNOG00000017226(gene)|ensembl:ENSRNOT00000023256(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)	rgd:61998|refseq:NP_062250.1|ensembl:ENSRNOG00000010945(gene)|ensembl:ENSRNOT00000016981(transcript)|go:"GO:0004860"(protein kinase inhibitor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006605"(protein targeting)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019899"(enzyme binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035308"(negative regulation of protein dephosphorylation)|go:"GO:0042470"(melanosome)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043085"(positive regulation of catalytic activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045744"(negative regulation of G protein-coupled receptor signaling pathway)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050815"(phosphoserine residue binding)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0051220"(cytoplasmic sequestering of protein)|interpro:IPR000308(14-3-3 protein)|interpro:IPR023409|interpro:IPR023410|interpro:IPR036815|mint:P35213|reactome:R-RNO-111447|reactome:R-RNO-165159|reactome:R-RNO-166208|reactome:R-RNO-170968|reactome:R-RNO-2028269|reactome:R-RNO-392517|reactome:R-RNO-450385|reactome:R-RNO-450513|reactome:R-RNO-5625740|reactome:R-RNO-5628897|reactome:R-RNO-5673000|reactome:R-RNO-5674135|reactome:R-RNO-5675221|reactome:R-RNO-75035|reactome:R-RNO-9614399	-	-	-	caution:"The participant EBI-349571(P68370) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919386(Q7TP47) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920972(Q5XIP9) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-916419(P11980) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919578(Q8R491) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920554(Q5U3Z7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920647(Q5U2X8) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920585(Q7TP24) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-779677(P05426) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-915744(P02454) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|agonist:Insulin was shown to increase or decrease GLUT4 protein interactions in specific cases.|comment:"Insulin decreased GLUT4 interactions with the following proteins: Q9ER30 (Sarcosin), P09527 (Rab-7), O88960 (N-ethylmaleimide sensitive), P09456 (PKA I regulatory subunit), P27881 (Hexokinase type II), P07872 (Acyl-coenzyme A oxidase), Q6DGF1 (Isocitrate dehydrogenase), Q9EQX9 (Ubiquitin-conjugating), Q63446 (Polyubiquitin), P24268 (Cathepsin D), Q91XW0 (Heat shock protein 86), Q5FVH0 (unknown), P58405 (Striatin 3), Q62667 (Major vault protein), Q66H50 (unknown), Q09167 (splicing factor), Q9JHU5 (Arfaptin 1)."|comment:"Insulin increased GLUT4 interaction with the following proteins:Q9Z1P2 (R-actinin-1), P45592 (Cofilin), Q9QXQ0 (R-actinin-4), P26473 (ADP-ribosylation factor), P26437 (ADP-ribosylation factor),   Q7TNP1 (Basigin 2), Q6P6R2 (Dihydrolipoamide dehydrogenase),   P04797 (GAPDH), Q63081 (Protein disulfide isomerase), P29457 (47 kDa heat shock protein), Q9R1J8 (Leprecan), O88638 (Putative eps protein),   Q64375 (Synaptonemal complex)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:NDPK - Interactions involving proteins containing InterPro domain IPR001564, Nucleoside diphosphate kinase, core.	taxid:10116(rat-l6)|taxid:10116(Rattus norvegicus)	-	2006/02/15	2021/11/30	rogid:PbFY2lfrty8yw40Jq7ShR7xfuV410116	rogid:L/MyYCTZ4ws1GPmT1Jyxa7gVcg010116	intact-crc:44F3A2176D02515F|rigid:9RVm0UBcqQF4k06RGKO89Bg16Q8	false	myc tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P19357	uniprotkb:P35053	intact:EBI-915426|uniprotkb:P97900|ensembl:ENSRNOP00000023256	intact:EBI-917302	psi-mi:glut4_rat(display_long)|uniprotkb:Glucose transporter type 4, insulin-responsive(gene name synonym)|uniprotkb:Slc2a4(gene name)|psi-mi:Slc2a4(display_short)|uniprotkb:Glut4(gene name synonym)	psi-mi:gpc1_rat(display_long)|uniprotkb:HSPG M12(gene name synonym)|uniprotkb:Gpc1(gene name)|psi-mi:Gpc1(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Foster et al. (2006)	pubmed:16396496|mint:MINT-5218203	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-921030	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2711|refseq:NP_036883.1|refseq:XP_006246658.1|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007611"(learning or memory)|go:"GO:0007614"(short-term memory)|go:"GO:0007616"(long-term memory)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010021"(amylopectin biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031550"(positive regulation of brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044381"(glucose import in response to insulin stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046323"(glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0098694"(regulation of synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0098793"(presynapse)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002441("Glucose transporter, type 4 (GLUT4)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-189200|ensembl:ENSRNOG00000017226(gene)|ensembl:ENSRNOT00000023256(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)	interpro:IPR001863(Glypican)|interpro:IPR015502(Glypican1)|interpro:IPR019803|rgd:61853|refseq:NP_110455.1|reactome:R-RNO-1971475|reactome:R-RNO-2022928|reactome:R-RNO-2024096|reactome:R-RNO-202733|reactome:R-RNO-975634|go:"GO:0005507"(copper ion binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005768"(endosome)|go:"GO:0009986"(cell surface)|go:"GO:0014037"(Schwann cell differentiation)|go:"GO:0016477"(cell migration)|go:"GO:0017134"(fibroblast growth factor binding)|go:"GO:0030200"(heparan sulfate proteoglycan catabolic process)|go:"GO:0031012"(extracellular matrix)|go:"GO:0032288"(myelin assembly)|go:"GO:0040037"(negative regulation of fibroblast growth factor receptor signaling pathway)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043236"(laminin binding)|go:"GO:0045121"(membrane raft)|go:"GO:0045202"(synapse)|go:"GO:0046658"(anchored component of plasma membrane)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070052"(collagen V binding)|go:"GO:1905475"(regulation of protein localization to membrane)|go:"GO:2001016"(positive regulation of skeletal muscle cell differentiation)	-	-	-	caution:"The participant EBI-349571(P68370) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919386(Q7TP47) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920972(Q5XIP9) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-916419(P11980) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919578(Q8R491) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920554(Q5U3Z7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920647(Q5U2X8) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920585(Q7TP24) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-779677(P05426) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-915744(P02454) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|agonist:Insulin was shown to increase or decrease GLUT4 protein interactions in specific cases.|comment:"Insulin decreased GLUT4 interactions with the following proteins: Q9ER30 (Sarcosin), P09527 (Rab-7), O88960 (N-ethylmaleimide sensitive), P09456 (PKA I regulatory subunit), P27881 (Hexokinase type II), P07872 (Acyl-coenzyme A oxidase), Q6DGF1 (Isocitrate dehydrogenase), Q9EQX9 (Ubiquitin-conjugating), Q63446 (Polyubiquitin), P24268 (Cathepsin D), Q91XW0 (Heat shock protein 86), Q5FVH0 (unknown), P58405 (Striatin 3), Q62667 (Major vault protein), Q66H50 (unknown), Q09167 (splicing factor), Q9JHU5 (Arfaptin 1)."|comment:"Insulin increased GLUT4 interaction with the following proteins:Q9Z1P2 (R-actinin-1), P45592 (Cofilin), Q9QXQ0 (R-actinin-4), P26473 (ADP-ribosylation factor), P26437 (ADP-ribosylation factor),   Q7TNP1 (Basigin 2), Q6P6R2 (Dihydrolipoamide dehydrogenase),   P04797 (GAPDH), Q63081 (Protein disulfide isomerase), P29457 (47 kDa heat shock protein), Q9R1J8 (Leprecan), O88638 (Putative eps protein),   Q64375 (Synaptonemal complex)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:NDPK - Interactions involving proteins containing InterPro domain IPR001564, Nucleoside diphosphate kinase, core.	taxid:10116(rat-l6)|taxid:10116(Rattus norvegicus)	-	2006/02/15	2021/11/30	rogid:PbFY2lfrty8yw40Jq7ShR7xfuV410116	rogid:+/YMHFC3XZ/OUf0+J/5GPt1ISxk10116	intact-crc:44F3A2176D02515F|rigid:9RVm0UBcqQF4k06RGKO89Bg16Q8	false	myc tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P19357	uniprotkb:P34926	intact:EBI-915426|uniprotkb:P97900|ensembl:ENSRNOP00000023256	intact:EBI-631571	psi-mi:glut4_rat(display_long)|uniprotkb:Glucose transporter type 4, insulin-responsive(gene name synonym)|uniprotkb:Slc2a4(gene name)|psi-mi:Slc2a4(display_short)|uniprotkb:Glut4(gene name synonym)	psi-mi:map1a_rat(display_long)|uniprotkb:Map1a(gene name)|psi-mi:Map1a(display_short)|uniprotkb:Mtap1a(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Foster et al. (2006)	pubmed:16396496|mint:MINT-5218203	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-921030	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2711|refseq:NP_036883.1|refseq:XP_006246658.1|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007611"(learning or memory)|go:"GO:0007614"(short-term memory)|go:"GO:0007616"(long-term memory)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010021"(amylopectin biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031550"(positive regulation of brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044381"(glucose import in response to insulin stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046323"(glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0098694"(regulation of synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0098793"(presynapse)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002441("Glucose transporter, type 4 (GLUT4)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-189200|ensembl:ENSRNOG00000017226(gene)|ensembl:ENSRNOT00000023256(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)	rgd:3042|refseq:NP_112257.1|go:"GO:0007026"(negative regulation of microtubule depolymerization)|go:"GO:0007409"(axonogenesis)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0007613"(memory)|go:"GO:0008017"(microtubule binding)|go:"GO:0008093"(cytoskeletal anchor activity)|go:"GO:0008306"(associative learning)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015631"(tubulin binding)|go:"GO:0016358"(dendrite development)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0031114"(regulation of microtubule depolymerization)|go:"GO:0032435"(negative regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043194"(axon initial segment)|go:"GO:0043198"(dendritic shaft)|go:"GO:0044307"(dendritic branch)|go:"GO:0045202"(synapse)|go:"GO:0045494"(photoreceptor cell maintenance)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0050882"(voluntary musculoskeletal movement)|go:"GO:0070050"(neuron cellular homeostasis)|go:"GO:0099641"(anterograde axonal protein transport)|go:"GO:0099642"(retrograde axonal protein transport)|go:"GO:0150001"(primary dendrite)|go:"GO:1901588"(dendritic microtubule)|go:"GO:1902817"(negative regulation of protein localization to microtubule)|go:"GO:1903829"(positive regulation of protein localization)|go:"GO:1904115"(axon cytoplasm)|go:"GO:1990535"(neuron projection maintenance)|go:"GO:2000010"(positive regulation of protein localization to cell surface)|interpro:IPR015656(MAP1A)|interpro:IPR026074|interpro:IPR036866|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0001750"(photoreceptor outer segment)|go:"GO:0003779"(actin binding)|go:"GO:0005518"(collagen binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0005875"(microtubule associated complex)|mint:P34926|dip:DIP-29265N	-	-	-	caution:"The participant EBI-349571(P68370) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919386(Q7TP47) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920972(Q5XIP9) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-916419(P11980) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919578(Q8R491) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920554(Q5U3Z7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920647(Q5U2X8) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920585(Q7TP24) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-779677(P05426) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-915744(P02454) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|agonist:Insulin was shown to increase or decrease GLUT4 protein interactions in specific cases.|comment:"Insulin decreased GLUT4 interactions with the following proteins: Q9ER30 (Sarcosin), P09527 (Rab-7), O88960 (N-ethylmaleimide sensitive), P09456 (PKA I regulatory subunit), P27881 (Hexokinase type II), P07872 (Acyl-coenzyme A oxidase), Q6DGF1 (Isocitrate dehydrogenase), Q9EQX9 (Ubiquitin-conjugating), Q63446 (Polyubiquitin), P24268 (Cathepsin D), Q91XW0 (Heat shock protein 86), Q5FVH0 (unknown), P58405 (Striatin 3), Q62667 (Major vault protein), Q66H50 (unknown), Q09167 (splicing factor), Q9JHU5 (Arfaptin 1)."|comment:"Insulin increased GLUT4 interaction with the following proteins:Q9Z1P2 (R-actinin-1), P45592 (Cofilin), Q9QXQ0 (R-actinin-4), P26473 (ADP-ribosylation factor), P26437 (ADP-ribosylation factor),   Q7TNP1 (Basigin 2), Q6P6R2 (Dihydrolipoamide dehydrogenase),   P04797 (GAPDH), Q63081 (Protein disulfide isomerase), P29457 (47 kDa heat shock protein), Q9R1J8 (Leprecan), O88638 (Putative eps protein),   Q64375 (Synaptonemal complex)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:NDPK - Interactions involving proteins containing InterPro domain IPR001564, Nucleoside diphosphate kinase, core.	taxid:10116(rat-l6)|taxid:10116(Rattus norvegicus)	-	2006/02/15	2021/11/30	rogid:PbFY2lfrty8yw40Jq7ShR7xfuV410116	rogid:KoMmjz9oNsuegJgHeF2bcf+Ybhs10116	intact-crc:44F3A2176D02515F|rigid:9RVm0UBcqQF4k06RGKO89Bg16Q8	false	myc tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P19357	uniprotkb:P34064	intact:EBI-915426|uniprotkb:P97900|ensembl:ENSRNOP00000023256	intact:EBI-917288	psi-mi:glut4_rat(display_long)|uniprotkb:Glucose transporter type 4, insulin-responsive(gene name synonym)|uniprotkb:Slc2a4(gene name)|psi-mi:Slc2a4(display_short)|uniprotkb:Glut4(gene name synonym)	psi-mi:psa5_rat(display_long)|uniprotkb:Proteasome zeta chain(gene name synonym)|uniprotkb:Macropain zeta chain(gene name synonym)|uniprotkb:Multicatalytic endopeptidase complex zeta chain(gene name synonym)|uniprotkb:Psma5(gene name)|psi-mi:Psma5(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Foster et al. (2006)	pubmed:16396496|mint:MINT-5218203	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-921030	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2711|refseq:NP_036883.1|refseq:XP_006246658.1|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007611"(learning or memory)|go:"GO:0007614"(short-term memory)|go:"GO:0007616"(long-term memory)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010021"(amylopectin biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031550"(positive regulation of brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044381"(glucose import in response to insulin stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046323"(glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0098694"(regulation of synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0098793"(presynapse)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002441("Glucose transporter, type 4 (GLUT4)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-189200|ensembl:ENSRNOG00000017226(gene)|ensembl:ENSRNOT00000023256(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)	interpro:IPR029055|rgd:61848|interpro:IPR000426(Proteasome alpha-subunit, conserved site)|interpro:IPR023332|interpro:IPR001353(20S proteasome, A and B subunits)|reactome:R-RNO-8932339|interpro:IPR033812|rcsb pdb:6EPC|rcsb pdb:6EPD|rcsb pdb:6EPE|rcsb pdb:6EPF|reactome:R-RNO-174084|reactome:R-RNO-5689603|reactome:R-RNO-5689880|reactome:R-RNO-6798695|reactome:R-RNO-68827|reactome:R-RNO-8951664|reactome:R-RNO-1234176|reactome:R-RNO-1236978|reactome:R-RNO-174154|reactome:R-RNO-174178|reactome:R-RNO-174184|reactome:R-RNO-187577|reactome:R-RNO-195253|reactome:R-RNO-2467813|reactome:R-RNO-349425|reactome:R-RNO-350562|reactome:R-RNO-382556|reactome:R-RNO-450408|reactome:R-RNO-4608870|reactome:R-RNO-4641257|reactome:R-RNO-4641258|reactome:R-RNO-5358346|reactome:R-RNO-5607761|reactome:R-RNO-5610780|reactome:R-RNO-5610785|reactome:R-RNO-5632684|reactome:R-RNO-5658442|reactome:R-RNO-5668541|reactome:R-RNO-5676590|reactome:R-RNO-5687128|reactome:R-RNO-68949|reactome:R-RNO-69017|reactome:R-RNO-69481|reactome:R-RNO-69601|reactome:R-RNO-75815|reactome:R-RNO-8852276|reactome:R-RNO-8854050|reactome:R-RNO-8939236|reactome:R-RNO-8941858|reactome:R-RNO-8948751|reactome:R-RNO-983168|rcsb pdb:6TU3|reactome:R-RNO-1169091|go:"GO:0000502"(proteasome complex)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005839"(proteasome core complex)|go:"GO:0010499"(proteasomal ubiquitin-independent protein catabolic process)|go:"GO:0019773"(proteasome core complex, alpha-subunit complex)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)	-	-	-	caution:"The participant EBI-349571(P68370) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919386(Q7TP47) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920972(Q5XIP9) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-916419(P11980) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919578(Q8R491) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920554(Q5U3Z7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920647(Q5U2X8) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920585(Q7TP24) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-779677(P05426) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-915744(P02454) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|agonist:Insulin was shown to increase or decrease GLUT4 protein interactions in specific cases.|comment:"Insulin decreased GLUT4 interactions with the following proteins: Q9ER30 (Sarcosin), P09527 (Rab-7), O88960 (N-ethylmaleimide sensitive), P09456 (PKA I regulatory subunit), P27881 (Hexokinase type II), P07872 (Acyl-coenzyme A oxidase), Q6DGF1 (Isocitrate dehydrogenase), Q9EQX9 (Ubiquitin-conjugating), Q63446 (Polyubiquitin), P24268 (Cathepsin D), Q91XW0 (Heat shock protein 86), Q5FVH0 (unknown), P58405 (Striatin 3), Q62667 (Major vault protein), Q66H50 (unknown), Q09167 (splicing factor), Q9JHU5 (Arfaptin 1)."|comment:"Insulin increased GLUT4 interaction with the following proteins:Q9Z1P2 (R-actinin-1), P45592 (Cofilin), Q9QXQ0 (R-actinin-4), P26473 (ADP-ribosylation factor), P26437 (ADP-ribosylation factor),   Q7TNP1 (Basigin 2), Q6P6R2 (Dihydrolipoamide dehydrogenase),   P04797 (GAPDH), Q63081 (Protein disulfide isomerase), P29457 (47 kDa heat shock protein), Q9R1J8 (Leprecan), O88638 (Putative eps protein),   Q64375 (Synaptonemal complex)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:NDPK - Interactions involving proteins containing InterPro domain IPR001564, Nucleoside diphosphate kinase, core.	taxid:10116(rat-l6)|taxid:10116(Rattus norvegicus)	-	2006/02/15	2021/11/30	rogid:PbFY2lfrty8yw40Jq7ShR7xfuV410116	rogid:VFQZGAdCNyjQYo4rU041+jUD7/010116	intact-crc:44F3A2176D02515F|rigid:9RVm0UBcqQF4k06RGKO89Bg16Q8	false	myc tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P19357	uniprotkb:P34058	intact:EBI-915426|uniprotkb:P97900|ensembl:ENSRNOP00000023256	intact:EBI-917279|uniprotkb:Q1PSW2|uniprotkb:Q66H55|uniprotkb:Q68GV5|uniprotkb:Q9QWC6|ensembl:ENSRNOP00000026920	psi-mi:glut4_rat(display_long)|uniprotkb:Glucose transporter type 4, insulin-responsive(gene name synonym)|uniprotkb:Slc2a4(gene name)|psi-mi:Slc2a4(display_short)|uniprotkb:Glut4(gene name synonym)	psi-mi:hs90b_rat(display_long)|uniprotkb:Heat shock 84 kDa(gene name synonym)|uniprotkb:Hsp90ab1(gene name)|psi-mi:Hsp90ab1(display_short)|uniprotkb:Hsp84(gene name synonym)|uniprotkb:Hspcb(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Foster et al. (2006)	pubmed:16396496|mint:MINT-5218203	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-921030	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2711|refseq:NP_036883.1|refseq:XP_006246658.1|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007611"(learning or memory)|go:"GO:0007614"(short-term memory)|go:"GO:0007616"(long-term memory)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010021"(amylopectin biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031550"(positive regulation of brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044381"(glucose import in response to insulin stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046323"(glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0098694"(regulation of synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0098793"(presynapse)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002441("Glucose transporter, type 4 (GLUT4)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-189200|ensembl:ENSRNOG00000017226(gene)|ensembl:ENSRNOT00000023256(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)	rgd:1303075|refseq:NP_001004082.3|ensembl:ENSRNOG00000019834(gene)|ensembl:ENSRNOT00000026920(transcript)|go:"GO:0001890"(placenta development)|go:"GO:0002134"(UTP binding)|go:"GO:0002135"(CTP binding)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005525"(GTP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006457"(protein folding)|go:"GO:0006986"(response to unfolded protein)|go:"GO:0007004"(telomere maintenance via telomerase)|go:"GO:0008180"(COP9 signalosome)|go:"GO:0009651"(response to salt stress)|go:"GO:0009986"(cell surface)|go:"GO:0010033"(response to organic substance)|go:"GO:0016234"(inclusion body)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0017098"(sulfonylurea receptor binding)|go:"GO:0019062"(virion attachment to host cell)|go:"GO:0019887"(protein kinase regulator activity)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0021955"(central nervous system neuron axonogenesis)|go:"GO:0030010"(establishment of cell polarity)|go:"GO:0030511"(positive regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031396"(regulation of protein ubiquitination)|go:"GO:0031526"(brush border membrane)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032435"(negative regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0032516"(positive regulation of phosphoprotein phosphatase activity)|go:"GO:0032564"(dATP binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0034605"(cellular response to heat)|go:"GO:0034751"(aryl hydrocarbon receptor complex)|go:"GO:0042220"(response to cocaine)|go:"GO:0042277"(peptide binding)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0042470"(melanosome)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043008"(ATP-dependent protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043202"(lysosomal lumen)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0044183"(protein folding chaperone)|go:"GO:0044294"(dendritic growth cone)|go:"GO:0044295"(axonal growth cone)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0045597"(positive regulation of cell differentiation)|go:"GO:0045793"(positive regulation of cell size)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0048156"(tau protein binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048675"(axon extension)|go:"GO:0050821"(protein stabilization)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051131"(chaperone-mediated protein complex assembly)|go:"GO:0051248"(negative regulation of protein metabolic process)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0051973"(positive regulation of telomerase activity)|go:"GO:0060334"(regulation of interferon-gamma-mediated signaling pathway)|go:"GO:0060338"(regulation of type I interferon-mediated signaling pathway)|go:"GO:0061635"(regulation of protein complex stability)|go:"GO:0061684"(chaperone-mediated autophagy)|go:"GO:0070182"(DNA polymerase binding)|go:"GO:0071353"(cellular response to interleukin-4)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0071902"(positive regulation of protein serine/threonine kinase activity)|go:"GO:0097435"(supramolecular fiber organization)|go:"GO:0097718"(disordered domain specific binding)|go:"GO:0120293"(dynein axonemal particle)|go:"GO:0140597"(protein carrier chaperone)|go:"GO:1901389"(negative regulation of transforming growth factor beta activation)|go:"GO:1901799"(negative regulation of proteasomal protein catabolic process)|go:"GO:1903660"(negative regulation of complement-dependent cytotoxicity)|go:"GO:1903827"|go:"GO:1904031"(positive regulation of cyclin-dependent protein kinase activity)|go:"GO:1905323"(telomerase holoenzyme complex assembly)|go:"GO:1990226"(histone methyltransferase binding)|go:"GO:1990565"(HSP90-CDC37 chaperone complex)|go:"GO:1990913"(sperm head plasma membrane)|go:"GO:1990917"(ooplasm)|go:"GO:2000010"(positive regulation of protein localization to cell surface)|interpro:IPR001404(Heat shock protein Hsp90)|interpro:IPR003594(ATP-binding region, ATPase-like)|interpro:IPR019805|interpro:IPR020568|interpro:IPR020575|interpro:IPR036890|interpro:IPR037196|mint:P34058|reactome:R-RNO-168928|reactome:R-RNO-2029482|reactome:R-RNO-3371497|reactome:R-RNO-3371511|reactome:R-RNO-3371568|reactome:R-RNO-3371571|reactome:R-RNO-399954|reactome:R-RNO-6798695|reactome:R-RNO-844456|reactome:R-RNO-8852276|reactome:R-RNO-8937144|reactome:R-RNO-8939211|reactome:R-RNO-9013418|reactome:R-RNO-9018519	-	-	-	caution:"The participant EBI-349571(P68370) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919386(Q7TP47) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920972(Q5XIP9) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-916419(P11980) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919578(Q8R491) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920554(Q5U3Z7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920647(Q5U2X8) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920585(Q7TP24) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-779677(P05426) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-915744(P02454) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|agonist:Insulin was shown to increase or decrease GLUT4 protein interactions in specific cases.|comment:"Insulin decreased GLUT4 interactions with the following proteins: Q9ER30 (Sarcosin), P09527 (Rab-7), O88960 (N-ethylmaleimide sensitive), P09456 (PKA I regulatory subunit), P27881 (Hexokinase type II), P07872 (Acyl-coenzyme A oxidase), Q6DGF1 (Isocitrate dehydrogenase), Q9EQX9 (Ubiquitin-conjugating), Q63446 (Polyubiquitin), P24268 (Cathepsin D), Q91XW0 (Heat shock protein 86), Q5FVH0 (unknown), P58405 (Striatin 3), Q62667 (Major vault protein), Q66H50 (unknown), Q09167 (splicing factor), Q9JHU5 (Arfaptin 1)."|comment:"Insulin increased GLUT4 interaction with the following proteins:Q9Z1P2 (R-actinin-1), P45592 (Cofilin), Q9QXQ0 (R-actinin-4), P26473 (ADP-ribosylation factor), P26437 (ADP-ribosylation factor),   Q7TNP1 (Basigin 2), Q6P6R2 (Dihydrolipoamide dehydrogenase),   P04797 (GAPDH), Q63081 (Protein disulfide isomerase), P29457 (47 kDa heat shock protein), Q9R1J8 (Leprecan), O88638 (Putative eps protein),   Q64375 (Synaptonemal complex)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:NDPK - Interactions involving proteins containing InterPro domain IPR001564, Nucleoside diphosphate kinase, core.	taxid:10116(rat-l6)|taxid:10116(Rattus norvegicus)	-	2006/02/15	2021/11/30	rogid:PbFY2lfrty8yw40Jq7ShR7xfuV410116	rogid:5/MXDESVXdwuWna0s87Ap19aLMA10116	intact-crc:44F3A2176D02515F|rigid:9RVm0UBcqQF4k06RGKO89Bg16Q8	false	myc tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P19357	uniprotkb:P32551	intact:EBI-915426|uniprotkb:P97900|ensembl:ENSRNOP00000023256	intact:EBI-917272|uniprotkb:Q5XIR3|ensembl:ENSRNOP00000021514	psi-mi:glut4_rat(display_long)|uniprotkb:Glucose transporter type 4, insulin-responsive(gene name synonym)|uniprotkb:Slc2a4(gene name)|psi-mi:Slc2a4(display_short)|uniprotkb:Glut4(gene name synonym)	psi-mi:qcr2_rat(display_long)|uniprotkb:Ubiquinol-cytochrome-c reductase complex core protein 2(gene name synonym)|uniprotkb:Core protein II(gene name synonym)|uniprotkb:Complex III subunit 2(gene name synonym)|uniprotkb:Uqcrc2(gene name)|psi-mi:Uqcrc2(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Foster et al. (2006)	pubmed:16396496|mint:MINT-5218203	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-921030	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2711|refseq:NP_036883.1|refseq:XP_006246658.1|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007611"(learning or memory)|go:"GO:0007614"(short-term memory)|go:"GO:0007616"(long-term memory)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010021"(amylopectin biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031550"(positive regulation of brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044381"(glucose import in response to insulin stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046323"(glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0098694"(regulation of synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0098793"(presynapse)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002441("Glucose transporter, type 4 (GLUT4)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-189200|ensembl:ENSRNOG00000017226(gene)|ensembl:ENSRNOT00000023256(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)	rgd:1359150|refseq:NP_001006971.1|ensembl:ENSRNOG00000036742(gene)|ensembl:ENSRNOT00000021514(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005750"(mitochondrial respiratory chain complex III)|go:"GO:0005751"(mitochondrial respiratory chain complex IV)|go:"GO:0006508"(proteolysis)|go:"GO:0042493"|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046872"(metal ion binding)|interpro:IPR001431(Peptidase M16, zinc-binding site)|interpro:IPR007863(Peptidase M16, C-terminal)|interpro:IPR011249(Metalloenzyme, LuxS/M16 peptidase-like, metal-binding)|interpro:IPR011765(Peptidase M16, N-terminal)|mint:P32551|reactome:R-RNO-611105	-	-	-	caution:"The participant EBI-349571(P68370) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919386(Q7TP47) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920972(Q5XIP9) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-916419(P11980) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919578(Q8R491) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920554(Q5U3Z7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920647(Q5U2X8) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920585(Q7TP24) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-779677(P05426) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-915744(P02454) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|agonist:Insulin was shown to increase or decrease GLUT4 protein interactions in specific cases.|comment:"Insulin decreased GLUT4 interactions with the following proteins: Q9ER30 (Sarcosin), P09527 (Rab-7), O88960 (N-ethylmaleimide sensitive), P09456 (PKA I regulatory subunit), P27881 (Hexokinase type II), P07872 (Acyl-coenzyme A oxidase), Q6DGF1 (Isocitrate dehydrogenase), Q9EQX9 (Ubiquitin-conjugating), Q63446 (Polyubiquitin), P24268 (Cathepsin D), Q91XW0 (Heat shock protein 86), Q5FVH0 (unknown), P58405 (Striatin 3), Q62667 (Major vault protein), Q66H50 (unknown), Q09167 (splicing factor), Q9JHU5 (Arfaptin 1)."|comment:"Insulin increased GLUT4 interaction with the following proteins:Q9Z1P2 (R-actinin-1), P45592 (Cofilin), Q9QXQ0 (R-actinin-4), P26473 (ADP-ribosylation factor), P26437 (ADP-ribosylation factor),   Q7TNP1 (Basigin 2), Q6P6R2 (Dihydrolipoamide dehydrogenase),   P04797 (GAPDH), Q63081 (Protein disulfide isomerase), P29457 (47 kDa heat shock protein), Q9R1J8 (Leprecan), O88638 (Putative eps protein),   Q64375 (Synaptonemal complex)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:NDPK - Interactions involving proteins containing InterPro domain IPR001564, Nucleoside diphosphate kinase, core.	taxid:10116(rat-l6)|taxid:10116(Rattus norvegicus)	-	2006/02/15	2021/11/30	rogid:PbFY2lfrty8yw40Jq7ShR7xfuV410116	rogid:HvF0+1g/n1jgbf7314R6bHEWXa810116	intact-crc:44F3A2176D02515F|rigid:9RVm0UBcqQF4k06RGKO89Bg16Q8	false	myc tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P19357	uniprotkb:P32089	intact:EBI-915426|uniprotkb:P97900|ensembl:ENSRNOP00000023256	intact:EBI-917262|uniprotkb:Q498T8|ensembl:ENSRNOP00000000306	psi-mi:glut4_rat(display_long)|uniprotkb:Glucose transporter type 4, insulin-responsive(gene name synonym)|uniprotkb:Slc2a4(gene name)|psi-mi:Slc2a4(display_short)|uniprotkb:Glut4(gene name synonym)	psi-mi:txtp_rat(display_long)|uniprotkb:Citrate transport protein(gene name synonym)|uniprotkb:Tricarboxylate carrier protein(gene name synonym)|uniprotkb:Solute carrier family 25 member 1(gene name synonym)|uniprotkb:Slc25a1(gene name)|psi-mi:Slc25a1(display_short)|uniprotkb:Slc20a3(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Foster et al. (2006)	pubmed:16396496|mint:MINT-5218203	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-921030	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2711|refseq:NP_036883.1|refseq:XP_006246658.1|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007611"(learning or memory)|go:"GO:0007614"(short-term memory)|go:"GO:0007616"(long-term memory)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010021"(amylopectin biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031550"(positive regulation of brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044381"(glucose import in response to insulin stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046323"(glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0098694"(regulation of synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0098793"(presynapse)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002441("Glucose transporter, type 4 (GLUT4)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-189200|ensembl:ENSRNOG00000017226(gene)|ensembl:ENSRNOT00000023256(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)	rgd:3703|refseq:NP_059003.1|ensembl:ENSRNOG00000038001(gene)|ensembl:ENSRNOT00000000306(transcript)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0006843"(mitochondrial citrate transmembrane transport)|go:"GO:0015137"(citrate transmembrane transporter activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0071913"(citrate secondary active transmembrane transporter activity)|interpro:IPR002067(Mitochondrial carrier protein)|interpro:IPR018108|interpro:IPR023395|reactome:R-RNO-70263|reactome:R-RNO-75105	-	-	-	caution:"The participant EBI-349571(P68370) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919386(Q7TP47) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920972(Q5XIP9) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-916419(P11980) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919578(Q8R491) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920554(Q5U3Z7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920647(Q5U2X8) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920585(Q7TP24) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-779677(P05426) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-915744(P02454) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|agonist:Insulin was shown to increase or decrease GLUT4 protein interactions in specific cases.|comment:"Insulin decreased GLUT4 interactions with the following proteins: Q9ER30 (Sarcosin), P09527 (Rab-7), O88960 (N-ethylmaleimide sensitive), P09456 (PKA I regulatory subunit), P27881 (Hexokinase type II), P07872 (Acyl-coenzyme A oxidase), Q6DGF1 (Isocitrate dehydrogenase), Q9EQX9 (Ubiquitin-conjugating), Q63446 (Polyubiquitin), P24268 (Cathepsin D), Q91XW0 (Heat shock protein 86), Q5FVH0 (unknown), P58405 (Striatin 3), Q62667 (Major vault protein), Q66H50 (unknown), Q09167 (splicing factor), Q9JHU5 (Arfaptin 1)."|comment:"Insulin increased GLUT4 interaction with the following proteins:Q9Z1P2 (R-actinin-1), P45592 (Cofilin), Q9QXQ0 (R-actinin-4), P26473 (ADP-ribosylation factor), P26437 (ADP-ribosylation factor),   Q7TNP1 (Basigin 2), Q6P6R2 (Dihydrolipoamide dehydrogenase),   P04797 (GAPDH), Q63081 (Protein disulfide isomerase), P29457 (47 kDa heat shock protein), Q9R1J8 (Leprecan), O88638 (Putative eps protein),   Q64375 (Synaptonemal complex)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:NDPK - Interactions involving proteins containing InterPro domain IPR001564, Nucleoside diphosphate kinase, core.	taxid:10116(rat-l6)|taxid:10116(Rattus norvegicus)	-	2006/02/15	2021/11/30	rogid:PbFY2lfrty8yw40Jq7ShR7xfuV410116	rogid:Qtev4XV6rt4KOBfb6GliK/JbGSg10116	intact-crc:44F3A2176D02515F|rigid:9RVm0UBcqQF4k06RGKO89Bg16Q8	false	myc tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P19357	uniprotkb:P31977	intact:EBI-915426|uniprotkb:P97900|ensembl:ENSRNOP00000023256	intact:EBI-917242|uniprotkb:Q5WQV4|uniprotkb:Q66H97|uniprotkb:Q8VHK3|ensembl:ENSRNOP00000046593	psi-mi:glut4_rat(display_long)|uniprotkb:Glucose transporter type 4, insulin-responsive(gene name synonym)|uniprotkb:Slc2a4(gene name)|psi-mi:Slc2a4(display_short)|uniprotkb:Glut4(gene name synonym)	psi-mi:ezri_rat(display_long)|uniprotkb:Vil2(gene name synonym)|uniprotkb:p81(gene name synonym)|uniprotkb:Cytovillin(gene name synonym)|uniprotkb:Villin-2(gene name synonym)|uniprotkb:Ezr(gene name)|psi-mi:Ezr(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Foster et al. (2006)	pubmed:16396496|mint:MINT-5218203	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-921030	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2711|refseq:NP_036883.1|refseq:XP_006246658.1|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007611"(learning or memory)|go:"GO:0007614"(short-term memory)|go:"GO:0007616"(long-term memory)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010021"(amylopectin biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031550"(positive regulation of brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044381"(glucose import in response to insulin stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046323"(glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0098694"(regulation of synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0098793"(presynapse)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002441("Glucose transporter, type 4 (GLUT4)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-189200|ensembl:ENSRNOG00000017226(gene)|ensembl:ENSRNOT00000023256(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)	rgd:621161|refseq:NP_062230.1|ensembl:ENSRNOG00000018524(gene)|ensembl:ENSRNOT00000046746(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001650"(fibrillar center)|go:"GO:0001726"(ruffle)|go:"GO:0001772"(immunological synapse)|go:"GO:0001931"(uropod)|go:"GO:0001951"(intestinal D-glucose absorption)|go:"GO:0003376"(sphingosine-1-phosphate receptor signaling pathway)|go:"GO:0003779"(actin binding)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005884"(actin filament)|go:"GO:0005886"(plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0005903"(brush border)|go:"GO:0005925"(focal adhesion)|go:"GO:0005938"(cell cortex)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0008017"(microtubule binding)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010737"(protein kinase A signaling)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019898"(extrinsic component of membrane)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030033"(microvillus assembly)|go:"GO:0030175"(filopodium)|go:"GO:0030315"(T-tubule)|go:"GO:0030855"(epithelial cell differentiation)|go:"GO:0030953"(astral microtubule organization)|go:"GO:0031528"(microvillus membrane)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0031623"(receptor internalization)|go:"GO:0032532"(regulation of microvillus length)|go:"GO:0032587"(ruffle membrane)|go:"GO:0032703"(negative regulation of interleukin-2 production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034236"(protein kinase A catalytic subunit binding)|go:"GO:0034237"(protein kinase A regulatory subunit binding)|go:"GO:0034629"|go:"GO:0035088"(establishment or maintenance of apical/basal cell polarity)|go:"GO:0036064"(ciliary basal body)|go:"GO:0040018"(positive regulation of multicellular organism growth)|go:"GO:0042802"(identical protein binding)|go:"GO:0042995"(cell projection)|go:"GO:0043622"(cortical microtubule organization)|go:"GO:0044297"(cell body)|go:"GO:0044393"(microspike)|go:"GO:0044548"(S100 protein binding)|go:"GO:0044853"(plasma membrane raft)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045121"(membrane raft)|go:"GO:0045177"(apical part of cell)|go:"GO:0046847"(filopodium assembly)|go:"GO:0048015"(phosphatidylinositol-mediated signaling)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050714"(positive regulation of protein secretion)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050860"(negative regulation of T cell receptor signaling pathway)|go:"GO:0051015"(actin filament binding)|go:"GO:0051017"(actin filament bundle assembly)|go:"GO:0051018"(protein kinase A binding)|go:"GO:0051117"(ATPase binding)|go:"GO:0051286"(cell tip)|go:"GO:0051660"(establishment of centrosome localization)|go:"GO:0061028"(establishment of endothelial barrier)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0071320"(cellular response to cAMP)|go:"GO:0071944"(cell periphery)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0072697"(protein localization to cell cortex)|go:"GO:0097449"(astrocyte projection)|go:"GO:0097454"(Schwann cell microvillus)|go:"GO:0097718"(disordered domain specific binding)|go:"GO:0098592"(cytoplasmic side of apical plasma membrane)|go:"GO:1902115"(regulation of organelle assembly)|go:"GO:1902896"(terminal web assembly)|go:"GO:1902966"(positive regulation of protein localization to early endosome)|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|go:"GO:1903364"(positive regulation of cellular protein catabolic process)|go:"GO:1903753"(negative regulation of p38MAPK cascade)|go:"GO:2000643"(positive regulation of early endosome to late endosome transport)|interpro:IPR000299(Band 4.1, N-terminal)|interpro:IPR000798(Ezrin/radixin/moesin ERM)|interpro:IPR008954(Moesin)|interpro:IPR011174(Ezrin/radixin/moesin)|interpro:IPR011259(Ezrin/radixin/moesin, C-terminal)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR014352(FERM/acyl-CoA-binding protein, 3-helical bundle)|interpro:IPR018979|interpro:IPR018980|interpro:IPR019747|interpro:IPR019748|interpro:IPR019749|interpro:IPR029071|interpro:IPR035963|interpro:IPR041789|reactome:R-RNO-373752|reactome:R-RNO-437239	-	-	-	caution:"The participant EBI-349571(P68370) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919386(Q7TP47) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920972(Q5XIP9) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-916419(P11980) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919578(Q8R491) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920554(Q5U3Z7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920647(Q5U2X8) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920585(Q7TP24) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-779677(P05426) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-915744(P02454) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|agonist:Insulin was shown to increase or decrease GLUT4 protein interactions in specific cases.|comment:"Insulin decreased GLUT4 interactions with the following proteins: Q9ER30 (Sarcosin), P09527 (Rab-7), O88960 (N-ethylmaleimide sensitive), P09456 (PKA I regulatory subunit), P27881 (Hexokinase type II), P07872 (Acyl-coenzyme A oxidase), Q6DGF1 (Isocitrate dehydrogenase), Q9EQX9 (Ubiquitin-conjugating), Q63446 (Polyubiquitin), P24268 (Cathepsin D), Q91XW0 (Heat shock protein 86), Q5FVH0 (unknown), P58405 (Striatin 3), Q62667 (Major vault protein), Q66H50 (unknown), Q09167 (splicing factor), Q9JHU5 (Arfaptin 1)."|comment:"Insulin increased GLUT4 interaction with the following proteins:Q9Z1P2 (R-actinin-1), P45592 (Cofilin), Q9QXQ0 (R-actinin-4), P26473 (ADP-ribosylation factor), P26437 (ADP-ribosylation factor),   Q7TNP1 (Basigin 2), Q6P6R2 (Dihydrolipoamide dehydrogenase),   P04797 (GAPDH), Q63081 (Protein disulfide isomerase), P29457 (47 kDa heat shock protein), Q9R1J8 (Leprecan), O88638 (Putative eps protein),   Q64375 (Synaptonemal complex)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:NDPK - Interactions involving proteins containing InterPro domain IPR001564, Nucleoside diphosphate kinase, core.	taxid:10116(rat-l6)|taxid:10116(Rattus norvegicus)	-	2006/02/15	2021/11/30	rogid:PbFY2lfrty8yw40Jq7ShR7xfuV410116	rogid:2udcesOWgp+JEk1HN7Ss0qo+1TQ10116	intact-crc:44F3A2176D02515F|rigid:9RVm0UBcqQF4k06RGKO89Bg16Q8	false	myc tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P19357	uniprotkb:P31399	intact:EBI-915426|uniprotkb:P97900|ensembl:ENSRNOP00000023256	intact:EBI-917233|ensembl:ENSRNOP00000004836	psi-mi:glut4_rat(display_long)|uniprotkb:Glucose transporter type 4, insulin-responsive(gene name synonym)|uniprotkb:Slc2a4(gene name)|psi-mi:Slc2a4(display_short)|uniprotkb:Glut4(gene name synonym)	psi-mi:atp5h_rat(display_long)|uniprotkb:Atp5pd(gene name)|psi-mi:Atp5pd(display_short)|uniprotkb:ATP synthase peripheral stalk subunit d(gene name synonym)|uniprotkb:Atp5h(gene name synonym)|uniprotkb:Atp5jd(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Foster et al. (2006)	pubmed:16396496|mint:MINT-5218203	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-921030	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2711|refseq:NP_036883.1|refseq:XP_006246658.1|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007611"(learning or memory)|go:"GO:0007614"(short-term memory)|go:"GO:0007616"(long-term memory)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010021"(amylopectin biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031550"(positive regulation of brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044381"(glucose import in response to insulin stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046323"(glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0098694"(regulation of synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0098793"(presynapse)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002441("Glucose transporter, type 4 (GLUT4)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-189200|ensembl:ENSRNOG00000017226(gene)|ensembl:ENSRNOT00000023256(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)	rgd:620083|refseq:NP_062256.1|ensembl:ENSRNOG00000003626(gene)|ensembl:ENSRNOT00000004836(transcript)|go:"GO:0000274"(mitochondrial proton-transporting ATP synthase, stator stalk)|go:"GO:0000276"("mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)")|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005753"(mitochondrial proton-transporting ATP synthase complex)|go:"GO:0015078"(proton transmembrane transporter activity)|go:"GO:0015986"(ATP synthesis coupled proton transport)|go:"GO:0042776"(mitochondrial ATP synthesis coupled proton transport)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046034"(ATP metabolic process)|go:"GO:1901653"(cellular response to peptide)|interpro:IPR008689(ATPase, F0 complex, subunit D, mitochondrial)|interpro:IPR036228|mint:P31399|reactome:R-RNO-163210|reactome:R-RNO-8949613	-	-	-	caution:"The participant EBI-349571(P68370) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919386(Q7TP47) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920972(Q5XIP9) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-916419(P11980) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919578(Q8R491) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920554(Q5U3Z7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920647(Q5U2X8) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920585(Q7TP24) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-779677(P05426) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-915744(P02454) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|agonist:Insulin was shown to increase or decrease GLUT4 protein interactions in specific cases.|comment:"Insulin decreased GLUT4 interactions with the following proteins: Q9ER30 (Sarcosin), P09527 (Rab-7), O88960 (N-ethylmaleimide sensitive), P09456 (PKA I regulatory subunit), P27881 (Hexokinase type II), P07872 (Acyl-coenzyme A oxidase), Q6DGF1 (Isocitrate dehydrogenase), Q9EQX9 (Ubiquitin-conjugating), Q63446 (Polyubiquitin), P24268 (Cathepsin D), Q91XW0 (Heat shock protein 86), Q5FVH0 (unknown), P58405 (Striatin 3), Q62667 (Major vault protein), Q66H50 (unknown), Q09167 (splicing factor), Q9JHU5 (Arfaptin 1)."|comment:"Insulin increased GLUT4 interaction with the following proteins:Q9Z1P2 (R-actinin-1), P45592 (Cofilin), Q9QXQ0 (R-actinin-4), P26473 (ADP-ribosylation factor), P26437 (ADP-ribosylation factor),   Q7TNP1 (Basigin 2), Q6P6R2 (Dihydrolipoamide dehydrogenase),   P04797 (GAPDH), Q63081 (Protein disulfide isomerase), P29457 (47 kDa heat shock protein), Q9R1J8 (Leprecan), O88638 (Putative eps protein),   Q64375 (Synaptonemal complex)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:NDPK - Interactions involving proteins containing InterPro domain IPR001564, Nucleoside diphosphate kinase, core.	taxid:10116(rat-l6)|taxid:10116(Rattus norvegicus)	-	2006/02/15	2021/11/30	rogid:PbFY2lfrty8yw40Jq7ShR7xfuV410116	rogid:a1M9m03ICQoQPzfrjdot96mD0X410116	intact-crc:44F3A2176D02515F|rigid:9RVm0UBcqQF4k06RGKO89Bg16Q8	false	myc tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P19357	uniprotkb:P31232	intact:EBI-915426|uniprotkb:P97900|ensembl:ENSRNOP00000023256	intact:EBI-917221|ensembl:ENSRNOP00000024030	psi-mi:glut4_rat(display_long)|uniprotkb:Glucose transporter type 4, insulin-responsive(gene name synonym)|uniprotkb:Slc2a4(gene name)|psi-mi:Slc2a4(display_short)|uniprotkb:Glut4(gene name synonym)	psi-mi:tagl_rat(display_long)|uniprotkb:Smooth muscle protein 22-alpha(gene name synonym)|uniprotkb:Tagln(gene name)|psi-mi:Tagln(display_short)|uniprotkb:Sm22(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Foster et al. (2006)	pubmed:16396496|mint:MINT-5218203	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-921030	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2711|refseq:NP_036883.1|refseq:XP_006246658.1|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007611"(learning or memory)|go:"GO:0007614"(short-term memory)|go:"GO:0007616"(long-term memory)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010021"(amylopectin biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031550"(positive regulation of brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044381"(glucose import in response to insulin stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046323"(glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0098694"(regulation of synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0098793"(presynapse)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002441("Glucose transporter, type 4 (GLUT4)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-189200|ensembl:ENSRNOG00000017226(gene)|ensembl:ENSRNOT00000023256(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)	rgd:3723|refseq:NP_113737.1|ensembl:ENSRNOG00000017628(gene)|ensembl:ENSRNOT00000024030(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0030855"(epithelial cell differentiation)|go:"GO:0051015"(actin filament binding)|interpro:IPR000557(Calponin repeat)|interpro:IPR001715(Calponin-like actin-binding)|interpro:IPR003096(SM22/calponin)|interpro:IPR029976|interpro:IPR036872	-	-	-	caution:"The participant EBI-349571(P68370) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919386(Q7TP47) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920972(Q5XIP9) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-916419(P11980) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919578(Q8R491) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920554(Q5U3Z7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920647(Q5U2X8) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920585(Q7TP24) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-779677(P05426) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-915744(P02454) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|agonist:Insulin was shown to increase or decrease GLUT4 protein interactions in specific cases.|comment:"Insulin decreased GLUT4 interactions with the following proteins: Q9ER30 (Sarcosin), P09527 (Rab-7), O88960 (N-ethylmaleimide sensitive), P09456 (PKA I regulatory subunit), P27881 (Hexokinase type II), P07872 (Acyl-coenzyme A oxidase), Q6DGF1 (Isocitrate dehydrogenase), Q9EQX9 (Ubiquitin-conjugating), Q63446 (Polyubiquitin), P24268 (Cathepsin D), Q91XW0 (Heat shock protein 86), Q5FVH0 (unknown), P58405 (Striatin 3), Q62667 (Major vault protein), Q66H50 (unknown), Q09167 (splicing factor), Q9JHU5 (Arfaptin 1)."|comment:"Insulin increased GLUT4 interaction with the following proteins:Q9Z1P2 (R-actinin-1), P45592 (Cofilin), Q9QXQ0 (R-actinin-4), P26473 (ADP-ribosylation factor), P26437 (ADP-ribosylation factor),   Q7TNP1 (Basigin 2), Q6P6R2 (Dihydrolipoamide dehydrogenase),   P04797 (GAPDH), Q63081 (Protein disulfide isomerase), P29457 (47 kDa heat shock protein), Q9R1J8 (Leprecan), O88638 (Putative eps protein),   Q64375 (Synaptonemal complex)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:NDPK - Interactions involving proteins containing InterPro domain IPR001564, Nucleoside diphosphate kinase, core.	taxid:10116(rat-l6)|taxid:10116(Rattus norvegicus)	-	2006/02/15	2021/11/30	rogid:PbFY2lfrty8yw40Jq7ShR7xfuV410116	rogid:R50TedhuYasAl3IUSReClYyTc0w10116	intact-crc:44F3A2176D02515F|rigid:9RVm0UBcqQF4k06RGKO89Bg16Q8	false	myc tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P19357	uniprotkb:P31000	intact:EBI-915426|uniprotkb:P97900|ensembl:ENSRNOP00000023256	intact:EBI-368510	psi-mi:glut4_rat(display_long)|uniprotkb:Glucose transporter type 4, insulin-responsive(gene name synonym)|uniprotkb:Slc2a4(gene name)|psi-mi:Slc2a4(display_short)|uniprotkb:Glut4(gene name synonym)	psi-mi:vime_rat(display_long)|uniprotkb:Vim(gene name)|psi-mi:Vim(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Foster et al. (2006)	pubmed:16396496|mint:MINT-5218203	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-921030	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2711|refseq:NP_036883.1|refseq:XP_006246658.1|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007611"(learning or memory)|go:"GO:0007614"(short-term memory)|go:"GO:0007616"(long-term memory)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010021"(amylopectin biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031550"(positive regulation of brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044381"(glucose import in response to insulin stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046323"(glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0098694"(regulation of synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0098793"(presynapse)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002441("Glucose transporter, type 4 (GLUT4)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-189200|ensembl:ENSRNOG00000017226(gene)|ensembl:ENSRNOT00000023256(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)	go:"GO:0044344"(cellular response to fibroblast growth factor stimulus)|go:"GO:0045098"(type III intermediate filament)|go:"GO:0045103"(intermediate filament-based process)|go:"GO:0045109"(intermediate filament organization)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0045444"(fat cell differentiation)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0046697"(decidualization)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050770"(regulation of axonogenesis)|go:"GO:0051721"(protein phosphatase 2A binding)|go:"GO:0060020"(Bergmann glial cell differentiation)|go:"GO:0060252"(positive regulation of glial cell proliferation)|go:"GO:0060395"(SMAD protein signal transduction)|go:"GO:0070307"(lens fiber cell development)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071225"(cellular response to muramyl dipeptide)|rgd:621646|refseq:NP_112402.1|go:"GO:0097110"(scaffold protein binding)|go:"GO:1900147"(regulation of Schwann cell migration)|go:"GO:1990254"(keratin filament binding)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR006821(Intermediate filament, DNA-binding region)|interpro:IPR018039|interpro:IPR027699|interpro:IPR039008|reactome:R-RNO-264870|reactome:R-RNO-390522|reactome:R-RNO-9013422|reactome:R-RNO-9646399|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0003723"(RNA binding)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005200"(structural constituent of cytoskeleton)|go:"GO:0005212"(structural constituent of eye lens)|go:"GO:0005737"(cytoplasm)|go:"GO:0005777"(peroxisome)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005882"(intermediate filament)|go:"GO:0005886"(plasma membrane)|go:"GO:0007568"(aging)|go:"GO:0009314"(response to radiation)|go:"GO:0010269"(response to selenium ion)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0014002"(astrocyte development)|go:"GO:0016363"(nuclear matrix)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030424"(axon)|go:"GO:0031252"(cell leading edge)|go:"GO:0032355"(response to estradiol)|go:"GO:0032967"(positive regulation of collagen biosynthetic process)|go:"GO:0033280"(response to vitamin D)|go:"GO:0042802"(identical protein binding)|go:"GO:0042995"(cell projection)|go:"GO:0043005"(neuron projection)|go:"GO:0043403"(skeletal muscle tissue regeneration)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0044297"(cell body)|go:"GO:0010043"(response to zinc ion)|mint:P31000|dip:DIP-31882N	-	-	-	caution:"The participant EBI-349571(P68370) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919386(Q7TP47) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920972(Q5XIP9) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-916419(P11980) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919578(Q8R491) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920554(Q5U3Z7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920647(Q5U2X8) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920585(Q7TP24) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-779677(P05426) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-915744(P02454) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|agonist:Insulin was shown to increase or decrease GLUT4 protein interactions in specific cases.|comment:"Insulin decreased GLUT4 interactions with the following proteins: Q9ER30 (Sarcosin), P09527 (Rab-7), O88960 (N-ethylmaleimide sensitive), P09456 (PKA I regulatory subunit), P27881 (Hexokinase type II), P07872 (Acyl-coenzyme A oxidase), Q6DGF1 (Isocitrate dehydrogenase), Q9EQX9 (Ubiquitin-conjugating), Q63446 (Polyubiquitin), P24268 (Cathepsin D), Q91XW0 (Heat shock protein 86), Q5FVH0 (unknown), P58405 (Striatin 3), Q62667 (Major vault protein), Q66H50 (unknown), Q09167 (splicing factor), Q9JHU5 (Arfaptin 1)."|comment:"Insulin increased GLUT4 interaction with the following proteins:Q9Z1P2 (R-actinin-1), P45592 (Cofilin), Q9QXQ0 (R-actinin-4), P26473 (ADP-ribosylation factor), P26437 (ADP-ribosylation factor),   Q7TNP1 (Basigin 2), Q6P6R2 (Dihydrolipoamide dehydrogenase),   P04797 (GAPDH), Q63081 (Protein disulfide isomerase), P29457 (47 kDa heat shock protein), Q9R1J8 (Leprecan), O88638 (Putative eps protein),   Q64375 (Synaptonemal complex)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:NDPK - Interactions involving proteins containing InterPro domain IPR001564, Nucleoside diphosphate kinase, core.	taxid:10116(rat-l6)|taxid:10116(Rattus norvegicus)	-	2006/02/15	2021/11/30	rogid:PbFY2lfrty8yw40Jq7ShR7xfuV410116	rogid:gXqxWYjgPhNbQNfJNwdt/Q4D4u010116	intact-crc:44F3A2176D02515F|rigid:9RVm0UBcqQF4k06RGKO89Bg16Q8	false	myc tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P19357	uniprotkb:P30904	intact:EBI-915426|uniprotkb:P97900|ensembl:ENSRNOP00000023256	intact:EBI-917216|ensembl:ENSRNOP00000008608|ensembl:ENSRNOP00000074316	psi-mi:glut4_rat(display_long)|uniprotkb:Glucose transporter type 4, insulin-responsive(gene name synonym)|uniprotkb:Slc2a4(gene name)|psi-mi:Slc2a4(display_short)|uniprotkb:Glut4(gene name synonym)	psi-mi:mif_rat(display_long)|uniprotkb:Phenylpyruvate tautomerase(gene name synonym)|uniprotkb:Glutathione-binding 13 kDa protein(gene name synonym)|uniprotkb:Mif(gene name)|psi-mi:Mif(display_short)|uniprotkb:L-dopachrome tautomerase(gene name synonym)|uniprotkb:L-dopachrome isomerase(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Foster et al. (2006)	pubmed:16396496|mint:MINT-5218203	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-921030	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2711|refseq:NP_036883.1|refseq:XP_006246658.1|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007611"(learning or memory)|go:"GO:0007614"(short-term memory)|go:"GO:0007616"(long-term memory)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010021"(amylopectin biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031550"(positive regulation of brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044381"(glucose import in response to insulin stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046323"(glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0098694"(regulation of synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0098793"(presynapse)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002441("Glucose transporter, type 4 (GLUT4)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-189200|ensembl:ENSRNOG00000017226(gene)|ensembl:ENSRNOT00000023256(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)	refseq:XP_008772068.1|rgd:621163|refseq:NP_112313.1|refseq:XP_017457271.1|ensembl:ENSRNOG00000006589(gene)|ensembl:ENSRNOG00000056076(gene)|ensembl:ENSRNOT00000008608(transcript)|ensembl:ENSRNOT00000077564(transcript)|go:"GO:0001516"(prostaglandin biosynthetic process)|go:"GO:0001819"(positive regulation of cytokine production)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0001942"(hair follicle development)|go:"GO:0002020"(protease binding)|go:"GO:0002035"(brain renin-angiotensin system)|go:"GO:0002675"(positive regulation of acute inflammatory response)|go:"GO:0002906"(negative regulation of mature B cell apoptotic process)|go:"GO:0004167"(dopachrome isomerase activity)|go:"GO:0005125"(cytokine activity)|go:"GO:0005126"(cytokine receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007420"(brain development)|go:"GO:0007568"(aging)|go:"GO:0007569"(cell aging)|go:"GO:0009408"(response to heat)|go:"GO:0009612"(response to mechanical stimulus)|go:"GO:0009725"(response to hormone)|go:"GO:0009986"(cell surface)|go:"GO:0010035"(response to inorganic substance)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010739"(positive regulation of protein kinase A signaling)|go:"GO:0010760"(negative regulation of macrophage chemotaxis)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0019752"(carboxylic acid metabolic process)|go:"GO:0030330"(DNA damage response, signal transduction by p53 class mediator)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0030890"(positive regulation of B cell proliferation)|go:"GO:0031666"(positive regulation of lipopolysaccharide-mediated signaling pathway)|go:"GO:0032269"(negative regulation of cellular protein metabolic process)|go:"GO:0032355"(response to estradiol)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032570"(response to progesterone)|go:"GO:0032572"(response to menaquinone)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032868"(response to insulin)|go:"GO:0033033"(negative regulation of myeloid cell apoptotic process)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0033197"(response to vitamin E)|go:"GO:0042056"(chemoattractant activity)|go:"GO:0042060"(wound healing)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042327"(positive regulation of phosphorylation)|go:"GO:0042493"|go:"GO:0042756"(drinking behavior)|go:"GO:0042802"(identical protein binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043268"(positive regulation of potassium ion transport)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043518"(negative regulation of DNA damage response, signal transduction by p53 class mediator)|go:"GO:0043588"(skin development)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045087"(innate immune response)|go:"GO:0045821"(positive regulation of glycolytic process)|go:"GO:0046326"(positive regulation of glucose import)|go:"GO:0048146"(positive regulation of fibroblast proliferation)|go:"GO:0048680"(positive regulation of axon regeneration)|go:"GO:0050178"(phenylpyruvate tautomerase activity)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050778"(positive regulation of immune response)|go:"GO:0051384"(response to glucocorticoid)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0061078"(positive regulation of prostaglandin secretion involved in immune response)|go:"GO:0061081"(positive regulation of myeloid leukocyte cytokine production involved in immune response)|go:"GO:0070207"(protein homotrimerization)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0090238"(positive regulation of arachidonic acid secretion)|go:"GO:0090344"(negative regulation of cell aging)|go:"GO:1902166"(negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator)|go:"GO:2000343"("positive regulation of chemokine (C-X-C motif) ligand 2 production")|interpro:IPR001398(Macrophage migration inhibitory factor)|interpro:IPR014347(Tautomerase)|interpro:IPR019829|mint:P30904|rcsb pdb:1FIM|reactome:R-RNO-202733|reactome:R-RNO-6798695	-	-	-	caution:"The participant EBI-349571(P68370) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919386(Q7TP47) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920972(Q5XIP9) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-916419(P11980) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919578(Q8R491) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920554(Q5U3Z7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920647(Q5U2X8) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920585(Q7TP24) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-779677(P05426) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-915744(P02454) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|agonist:Insulin was shown to increase or decrease GLUT4 protein interactions in specific cases.|comment:"Insulin decreased GLUT4 interactions with the following proteins: Q9ER30 (Sarcosin), P09527 (Rab-7), O88960 (N-ethylmaleimide sensitive), P09456 (PKA I regulatory subunit), P27881 (Hexokinase type II), P07872 (Acyl-coenzyme A oxidase), Q6DGF1 (Isocitrate dehydrogenase), Q9EQX9 (Ubiquitin-conjugating), Q63446 (Polyubiquitin), P24268 (Cathepsin D), Q91XW0 (Heat shock protein 86), Q5FVH0 (unknown), P58405 (Striatin 3), Q62667 (Major vault protein), Q66H50 (unknown), Q09167 (splicing factor), Q9JHU5 (Arfaptin 1)."|comment:"Insulin increased GLUT4 interaction with the following proteins:Q9Z1P2 (R-actinin-1), P45592 (Cofilin), Q9QXQ0 (R-actinin-4), P26473 (ADP-ribosylation factor), P26437 (ADP-ribosylation factor),   Q7TNP1 (Basigin 2), Q6P6R2 (Dihydrolipoamide dehydrogenase),   P04797 (GAPDH), Q63081 (Protein disulfide isomerase), P29457 (47 kDa heat shock protein), Q9R1J8 (Leprecan), O88638 (Putative eps protein),   Q64375 (Synaptonemal complex)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:NDPK - Interactions involving proteins containing InterPro domain IPR001564, Nucleoside diphosphate kinase, core.	taxid:10116(rat-l6)|taxid:10116(Rattus norvegicus)	-	2006/02/15	2021/11/30	rogid:PbFY2lfrty8yw40Jq7ShR7xfuV410116	rogid:IKr3IOgugXY3QiwggmHWGn9D8d810116	intact-crc:44F3A2176D02515F|rigid:9RVm0UBcqQF4k06RGKO89Bg16Q8	false	myc tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P19357	uniprotkb:P30839	intact:EBI-915426|uniprotkb:P97900|ensembl:ENSRNOP00000023256	intact:EBI-917206	psi-mi:glut4_rat(display_long)|uniprotkb:Glucose transporter type 4, insulin-responsive(gene name synonym)|uniprotkb:Slc2a4(gene name)|psi-mi:Slc2a4(display_short)|uniprotkb:Glut4(gene name synonym)	psi-mi:al3a2_rat(display_long)|uniprotkb:Aldehyde dehydrogenase 4(gene name synonym)|uniprotkb:Microsomal aldehyde dehydrogenase(gene name synonym)|uniprotkb:Aldh3a2(gene name)|psi-mi:Aldh3a2(display_short)|uniprotkb:Aldh4(gene name synonym)|uniprotkb:Fatty aldehyde dehydrogenase(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Foster et al. (2006)	pubmed:16396496|mint:MINT-5218203	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-921030	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2711|refseq:NP_036883.1|refseq:XP_006246658.1|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007611"(learning or memory)|go:"GO:0007614"(short-term memory)|go:"GO:0007616"(long-term memory)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010021"(amylopectin biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031550"(positive regulation of brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044381"(glucose import in response to insulin stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046323"(glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0098694"(regulation of synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0098793"(presynapse)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002441("Glucose transporter, type 4 (GLUT4)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-189200|ensembl:ENSRNOG00000017226(gene)|ensembl:ENSRNOT00000023256(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)	interpro:IPR029510|rgd:61866|refseq:NP_113919.2|interpro:IPR016161(Aldehyde/histidinol dehydrogenase)|interpro:IPR016160(Aldehyde dehydrogenase, conserved site)|interpro:IPR016162(Aldehyde dehydrogenase, N-terminal)|interpro:IPR015590(Aldehyde dehydrogenase)|interpro:IPR012394("Aldehyde dehydrogenase NAD(P)-dependent")|reactome:R-RNO-9696270|reactome:R-RNO-9696273|interpro:IPR016163(Aldehyde dehydrogenase, C-terminal)|reactome:R-RNO-1660661|reactome:R-RNO-389599|reactome:R-RNO-9603798|reactome:R-RNO-9609523|go:"GO:0000302"(response to reactive oxygen species)|go:"GO:0004028"(3-chloroallyl aldehyde dehydrogenase activity)|go:"GO:0004029"("aldehyde dehydrogenase (NAD+) activity")|go:"GO:0005634"(nucleus)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0006081"(cellular aldehyde metabolic process)|go:"GO:0006631"(fatty acid metabolic process)|go:"GO:0007417"(central nervous system development)|go:"GO:0007422"(peripheral nervous system development)|go:"GO:0008544"(epidermis development)|go:"GO:0016021"(integral component of membrane)|go:"GO:0033306"(phytol metabolic process)|go:"GO:0042406"(extrinsic component of endoplasmic reticulum membrane)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043878"("glyceraldehyde-3-phosphate dehydrogenase (NAD+) (non-phosphorylating) activity")|go:"GO:0046292"(formaldehyde metabolic process)|go:"GO:0046458"(hexadecanal metabolic process)|go:"GO:0046577"(long-chain-alcohol oxidase activity)|go:"GO:0050061"(long-chain-aldehyde dehydrogenase activity)|go:"GO:0052814"(medium-chain-aldehyde dehydrogenase activity)	-	-	-	caution:"The participant EBI-349571(P68370) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919386(Q7TP47) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920972(Q5XIP9) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-916419(P11980) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919578(Q8R491) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920554(Q5U3Z7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920647(Q5U2X8) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920585(Q7TP24) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-779677(P05426) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-915744(P02454) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|agonist:Insulin was shown to increase or decrease GLUT4 protein interactions in specific cases.|comment:"Insulin decreased GLUT4 interactions with the following proteins: Q9ER30 (Sarcosin), P09527 (Rab-7), O88960 (N-ethylmaleimide sensitive), P09456 (PKA I regulatory subunit), P27881 (Hexokinase type II), P07872 (Acyl-coenzyme A oxidase), Q6DGF1 (Isocitrate dehydrogenase), Q9EQX9 (Ubiquitin-conjugating), Q63446 (Polyubiquitin), P24268 (Cathepsin D), Q91XW0 (Heat shock protein 86), Q5FVH0 (unknown), P58405 (Striatin 3), Q62667 (Major vault protein), Q66H50 (unknown), Q09167 (splicing factor), Q9JHU5 (Arfaptin 1)."|comment:"Insulin increased GLUT4 interaction with the following proteins:Q9Z1P2 (R-actinin-1), P45592 (Cofilin), Q9QXQ0 (R-actinin-4), P26473 (ADP-ribosylation factor), P26437 (ADP-ribosylation factor),   Q7TNP1 (Basigin 2), Q6P6R2 (Dihydrolipoamide dehydrogenase),   P04797 (GAPDH), Q63081 (Protein disulfide isomerase), P29457 (47 kDa heat shock protein), Q9R1J8 (Leprecan), O88638 (Putative eps protein),   Q64375 (Synaptonemal complex)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:NDPK - Interactions involving proteins containing InterPro domain IPR001564, Nucleoside diphosphate kinase, core.	taxid:10116(rat-l6)|taxid:10116(Rattus norvegicus)	-	2006/02/15	2021/11/30	rogid:PbFY2lfrty8yw40Jq7ShR7xfuV410116	rogid:7xpVWchSyUO0pwI296wDHlruyMk10116	intact-crc:44F3A2176D02515F|rigid:9RVm0UBcqQF4k06RGKO89Bg16Q8	false	myc tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P19357	uniprotkb:P30427	intact:EBI-915426|uniprotkb:P97900|ensembl:ENSRNOP00000023256	intact:EBI-917155|uniprotkb:O08879|uniprotkb:O08880|uniprotkb:O08881	psi-mi:glut4_rat(display_long)|uniprotkb:Glucose transporter type 4, insulin-responsive(gene name synonym)|uniprotkb:Slc2a4(gene name)|psi-mi:Slc2a4(display_short)|uniprotkb:Glut4(gene name synonym)	psi-mi:plec_rat(display_long)|uniprotkb:Plec(gene name)|psi-mi:Plec(display_short)|uniprotkb:Plec1(gene name synonym)|uniprotkb:Plectin-1(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Foster et al. (2006)	pubmed:16396496|mint:MINT-5218203	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-921030	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2711|refseq:NP_036883.1|refseq:XP_006246658.1|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007611"(learning or memory)|go:"GO:0007614"(short-term memory)|go:"GO:0007616"(long-term memory)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010021"(amylopectin biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031550"(positive regulation of brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044381"(glucose import in response to insulin stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046323"(glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0098694"(regulation of synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0098793"(presynapse)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002441("Glucose transporter, type 4 (GLUT4)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-189200|ensembl:ENSRNOG00000017226(gene)|ensembl:ENSRNOT00000023256(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)	interpro:IPR001452(Src homology-3)|interpro:IPR043197|mint:P30427|rgd:621649|interpro:IPR001589(Actinin-type, actin-binding, conserved site)|interpro:IPR001715(Calponin-like actin-binding)|interpro:IPR001101(Plectin repeat)|interpro:IPR005326(Plectin/S10, N-terminal)|interpro:IPR018159|interpro:IPR030269|interpro:IPR036388|interpro:IPR035915|interpro:IPR036872|interpro:IPR041573|interpro:IPR041615|go:"GO:0000902"(cell morphogenesis)|go:"GO:0002162"(dystroglycan binding)|go:"GO:0002522"(leukocyte migration involved in immune response)|go:"GO:0003334"(keratinocyte development)|go:"GO:0003779"(actin binding)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005200"(structural constituent of cytoskeleton)|go:"GO:0005737"(cytoplasm)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005903"(brush border)|go:"GO:0005925"(focal adhesion)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0007519"(skeletal muscle tissue development)|go:"GO:0007565"(female pregnancy)|go:"GO:0007584"(response to nutrient)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0008307"(structural constituent of muscle)|go:"GO:0009925"(basal plasma membrane)|go:"GO:0010467"(gene expression)|go:"GO:0010761"(fibroblast migration)|go:"GO:0010818"(T cell chemotaxis)|go:"GO:0014866"(skeletal myofibril assembly)|go:"GO:0016020"(membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016528"(sarcoplasm)|go:"GO:0019226"(transmission of nerve impulse)|go:"GO:0022011"(myelination in peripheral nervous system)|go:"GO:0030018"(Z disc)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030056"(hemidesmosome)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030506"(ankyrin binding)|go:"GO:0030855"(epithelial cell differentiation)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0031581"(hemidesmosome assembly)|go:"GO:0031668"(cellular response to extracellular stimulus)|go:"GO:0032094"(response to food)|go:"GO:0032287"(peripheral nervous system myelin maintenance)|go:"GO:0034613"(cellular protein localization)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0042060"(wound healing)|go:"GO:0042383"(sarcolemma)|go:"GO:0043034"(costamere)|go:"GO:0043209"(myelin sheath)|go:"GO:0043292"(contractile fiber)|go:"GO:0043588"(skin development)|go:"GO:0043621"(protein self-association)|go:"GO:0043933"(protein-containing complex organization)|go:"GO:0045104"(intermediate filament cytoskeleton organization)|go:"GO:0045109"(intermediate filament organization)|go:"GO:0045214"(sarcomere organization)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048741"(skeletal muscle fiber development)|go:"GO:0048870"(cell motility)|go:"GO:0051015"(actin filament binding)|go:"GO:0055013"(cardiac muscle cell development)|go:"GO:0061436"(establishment of skin barrier)|go:"GO:0070584"(mitochondrion morphogenesis)|go:"GO:0071498"(cellular response to fluid shear stress)|go:"GO:0071944"(cell periphery)|reactome:R-RNO-264870|reactome:R-RNO-446107	-	-	-	caution:"The participant EBI-349571(P68370) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919386(Q7TP47) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920972(Q5XIP9) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-916419(P11980) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919578(Q8R491) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920554(Q5U3Z7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920647(Q5U2X8) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920585(Q7TP24) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-779677(P05426) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-915744(P02454) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|agonist:Insulin was shown to increase or decrease GLUT4 protein interactions in specific cases.|comment:"Insulin decreased GLUT4 interactions with the following proteins: Q9ER30 (Sarcosin), P09527 (Rab-7), O88960 (N-ethylmaleimide sensitive), P09456 (PKA I regulatory subunit), P27881 (Hexokinase type II), P07872 (Acyl-coenzyme A oxidase), Q6DGF1 (Isocitrate dehydrogenase), Q9EQX9 (Ubiquitin-conjugating), Q63446 (Polyubiquitin), P24268 (Cathepsin D), Q91XW0 (Heat shock protein 86), Q5FVH0 (unknown), P58405 (Striatin 3), Q62667 (Major vault protein), Q66H50 (unknown), Q09167 (splicing factor), Q9JHU5 (Arfaptin 1)."|comment:"Insulin increased GLUT4 interaction with the following proteins:Q9Z1P2 (R-actinin-1), P45592 (Cofilin), Q9QXQ0 (R-actinin-4), P26473 (ADP-ribosylation factor), P26437 (ADP-ribosylation factor),   Q7TNP1 (Basigin 2), Q6P6R2 (Dihydrolipoamide dehydrogenase),   P04797 (GAPDH), Q63081 (Protein disulfide isomerase), P29457 (47 kDa heat shock protein), Q9R1J8 (Leprecan), O88638 (Putative eps protein),   Q64375 (Synaptonemal complex)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:NDPK - Interactions involving proteins containing InterPro domain IPR001564, Nucleoside diphosphate kinase, core.	taxid:10116(rat-l6)|taxid:10116(Rattus norvegicus)	-	2006/02/15	2021/11/30	rogid:PbFY2lfrty8yw40Jq7ShR7xfuV410116	rogid:LQJzfjJNnr1XQnkT1Zv+NvCA71I10116	intact-crc:44F3A2176D02515F|rigid:9RVm0UBcqQF4k06RGKO89Bg16Q8	false	myc tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P19357	uniprotkb:P29457	intact:EBI-915426|uniprotkb:P97900|ensembl:ENSRNOP00000023256	intact:EBI-917146	psi-mi:glut4_rat(display_long)|uniprotkb:Glucose transporter type 4, insulin-responsive(gene name synonym)|uniprotkb:Slc2a4(gene name)|psi-mi:Slc2a4(display_short)|uniprotkb:Glut4(gene name synonym)	psi-mi:serph_rat(display_long)|uniprotkb:Collagen-binding protein(gene name synonym)|uniprotkb:47 kDa heat shock protein(gene name synonym)|uniprotkb:GP46(gene name synonym)|uniprotkb:Serpinh1(gene name)|psi-mi:Serpinh1(display_short)|uniprotkb:Cbp1(gene name synonym)|uniprotkb:Hsp47(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Foster et al. (2006)	pubmed:16396496|mint:MINT-5218203	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-921030	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2711|refseq:NP_036883.1|refseq:XP_006246658.1|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007611"(learning or memory)|go:"GO:0007614"(short-term memory)|go:"GO:0007616"(long-term memory)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010021"(amylopectin biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031550"(positive regulation of brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044381"(glucose import in response to insulin stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046323"(glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0098694"(regulation of synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0098793"(presynapse)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002441("Glucose transporter, type 4 (GLUT4)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-189200|ensembl:ENSRNOG00000017226(gene)|ensembl:ENSRNOT00000023256(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)	interpro:IPR042178|interpro:IPR042185|rgd:69302|refseq:NP_058869.1|interpro:IPR000215(Protease inhibitor I4, serpin)|interpro:IPR023795|interpro:IPR023796|interpro:IPR033547|interpro:IPR033830|interpro:IPR036186|reactome:R-RNO-1650814|go:"GO:0003433"(chondrocyte development involved in endochondral bone morphogenesis)|go:"GO:0004867"(serine-type endopeptidase inhibitor activity)|go:"GO:0005518"(collagen binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005793"(endoplasmic reticulum-Golgi intermediate compartment)|go:"GO:0010951"(negative regulation of endopeptidase activity)|go:"GO:0030199"(collagen fibril organization)|go:"GO:0032964"(collagen biosynthetic process)|go:"GO:0045121"(membrane raft)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051604"(protein maturation)	-	-	-	caution:"The participant EBI-349571(P68370) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919386(Q7TP47) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920972(Q5XIP9) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-916419(P11980) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919578(Q8R491) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920554(Q5U3Z7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920647(Q5U2X8) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920585(Q7TP24) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-779677(P05426) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-915744(P02454) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|agonist:Insulin was shown to increase or decrease GLUT4 protein interactions in specific cases.|comment:"Insulin decreased GLUT4 interactions with the following proteins: Q9ER30 (Sarcosin), P09527 (Rab-7), O88960 (N-ethylmaleimide sensitive), P09456 (PKA I regulatory subunit), P27881 (Hexokinase type II), P07872 (Acyl-coenzyme A oxidase), Q6DGF1 (Isocitrate dehydrogenase), Q9EQX9 (Ubiquitin-conjugating), Q63446 (Polyubiquitin), P24268 (Cathepsin D), Q91XW0 (Heat shock protein 86), Q5FVH0 (unknown), P58405 (Striatin 3), Q62667 (Major vault protein), Q66H50 (unknown), Q09167 (splicing factor), Q9JHU5 (Arfaptin 1)."|comment:"Insulin increased GLUT4 interaction with the following proteins:Q9Z1P2 (R-actinin-1), P45592 (Cofilin), Q9QXQ0 (R-actinin-4), P26473 (ADP-ribosylation factor), P26437 (ADP-ribosylation factor),   Q7TNP1 (Basigin 2), Q6P6R2 (Dihydrolipoamide dehydrogenase),   P04797 (GAPDH), Q63081 (Protein disulfide isomerase), P29457 (47 kDa heat shock protein), Q9R1J8 (Leprecan), O88638 (Putative eps protein),   Q64375 (Synaptonemal complex)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:NDPK - Interactions involving proteins containing InterPro domain IPR001564, Nucleoside diphosphate kinase, core.	taxid:10116(rat-l6)|taxid:10116(Rattus norvegicus)	-	2006/02/15	2021/11/30	rogid:PbFY2lfrty8yw40Jq7ShR7xfuV410116	rogid:tXPWtdAIpCAvUcMKAHgjTeK5A1010116	intact-crc:44F3A2176D02515F|rigid:9RVm0UBcqQF4k06RGKO89Bg16Q8	false	myc tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P19357	uniprotkb:P29419	intact:EBI-915426|uniprotkb:P97900|ensembl:ENSRNOP00000023256	intact:EBI-917140|ensembl:ENSRNOP00000000072	psi-mi:glut4_rat(display_long)|uniprotkb:Glucose transporter type 4, insulin-responsive(gene name synonym)|uniprotkb:Slc2a4(gene name)|psi-mi:Slc2a4(display_short)|uniprotkb:Glut4(gene name synonym)	psi-mi:atp5i_rat(display_long)|uniprotkb:Atp5me(gene name)|psi-mi:Atp5me(display_short)|uniprotkb:ATP synthase membrane subunit e(gene name synonym)|uniprotkb:Atp5i(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Foster et al. (2006)	pubmed:16396496|mint:MINT-5218203	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-921030	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2711|refseq:NP_036883.1|refseq:XP_006246658.1|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007611"(learning or memory)|go:"GO:0007614"(short-term memory)|go:"GO:0007616"(long-term memory)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010021"(amylopectin biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031550"(positive regulation of brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044381"(glucose import in response to insulin stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046323"(glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0098694"(regulation of synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0098793"(presynapse)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002441("Glucose transporter, type 4 (GLUT4)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-189200|ensembl:ENSRNOG00000017226(gene)|ensembl:ENSRNOT00000023256(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)	rgd:621377|refseq:NP_536729.1|ensembl:ENSRNOG00000000064(gene)|ensembl:ENSRNOT00000000072(transcript)|go:"GO:0000276"("mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)")|go:"GO:0005739"(mitochondrion)|go:"GO:0005753"(mitochondrial proton-transporting ATP synthase complex)|go:"GO:0042776"(mitochondrial ATP synthesis coupled proton transport)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046034"(ATP metabolic process)|go:"GO:0046933"(proton-transporting ATP synthase activity, rotational mechanism)|interpro:IPR008386(ATPase, F0 complex, subunit E, mitochondrial)|mint:P29419|reactome:R-RNO-163210|reactome:R-RNO-8949613	-	-	-	caution:"The participant EBI-349571(P68370) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919386(Q7TP47) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920972(Q5XIP9) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-916419(P11980) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919578(Q8R491) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920554(Q5U3Z7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920647(Q5U2X8) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920585(Q7TP24) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-779677(P05426) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-915744(P02454) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|agonist:Insulin was shown to increase or decrease GLUT4 protein interactions in specific cases.|comment:"Insulin decreased GLUT4 interactions with the following proteins: Q9ER30 (Sarcosin), P09527 (Rab-7), O88960 (N-ethylmaleimide sensitive), P09456 (PKA I regulatory subunit), P27881 (Hexokinase type II), P07872 (Acyl-coenzyme A oxidase), Q6DGF1 (Isocitrate dehydrogenase), Q9EQX9 (Ubiquitin-conjugating), Q63446 (Polyubiquitin), P24268 (Cathepsin D), Q91XW0 (Heat shock protein 86), Q5FVH0 (unknown), P58405 (Striatin 3), Q62667 (Major vault protein), Q66H50 (unknown), Q09167 (splicing factor), Q9JHU5 (Arfaptin 1)."|comment:"Insulin increased GLUT4 interaction with the following proteins:Q9Z1P2 (R-actinin-1), P45592 (Cofilin), Q9QXQ0 (R-actinin-4), P26473 (ADP-ribosylation factor), P26437 (ADP-ribosylation factor),   Q7TNP1 (Basigin 2), Q6P6R2 (Dihydrolipoamide dehydrogenase),   P04797 (GAPDH), Q63081 (Protein disulfide isomerase), P29457 (47 kDa heat shock protein), Q9R1J8 (Leprecan), O88638 (Putative eps protein),   Q64375 (Synaptonemal complex)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:NDPK - Interactions involving proteins containing InterPro domain IPR001564, Nucleoside diphosphate kinase, core.	taxid:10116(rat-l6)|taxid:10116(Rattus norvegicus)	-	2006/02/15	2021/11/30	rogid:PbFY2lfrty8yw40Jq7ShR7xfuV410116	rogid:vDzdXol5QxGCYvcTMmV5MTUz/QQ10116	intact-crc:44F3A2176D02515F|rigid:9RVm0UBcqQF4k06RGKO89Bg16Q8	false	myc tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P19357	uniprotkb:P29315	intact:EBI-915426|uniprotkb:P97900|ensembl:ENSRNOP00000023256	intact:EBI-917131|uniprotkb:Q6IRS9	psi-mi:glut4_rat(display_long)|uniprotkb:Glucose transporter type 4, insulin-responsive(gene name synonym)|uniprotkb:Slc2a4(gene name)|psi-mi:Slc2a4(display_short)|uniprotkb:Glut4(gene name synonym)	psi-mi:rini_rat(display_long)|uniprotkb:Ribonuclease/angiogenin inhibitor 1(gene name synonym)|uniprotkb:Rnh1(gene name)|psi-mi:Rnh1(display_short)|uniprotkb:Rnh(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Foster et al. (2006)	pubmed:16396496|mint:MINT-5218203	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-921030	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2711|refseq:NP_036883.1|refseq:XP_006246658.1|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007611"(learning or memory)|go:"GO:0007614"(short-term memory)|go:"GO:0007616"(long-term memory)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010021"(amylopectin biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031550"(positive regulation of brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044381"(glucose import in response to insulin stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046323"(glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0098694"(regulation of synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0098793"(presynapse)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002441("Glucose transporter, type 4 (GLUT4)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-189200|ensembl:ENSRNOG00000017226(gene)|ensembl:ENSRNOT00000023256(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)	refseq:NP_001257691.1|rgd:621398|refseq:NP_620805.2|interpro:IPR001611(Leucine-rich repeat)|refseq:NP_001257692.1|interpro:IPR032675|interpro:IPR041302|go:"GO:0005737"(cytoplasm)|go:"GO:0008428"(ribonuclease inhibitor activity)|go:"GO:0032311"(angiogenin-PRI complex)|go:"GO:0045765"(regulation of angiogenesis)	-	-	-	caution:"The participant EBI-349571(P68370) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919386(Q7TP47) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920972(Q5XIP9) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-916419(P11980) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919578(Q8R491) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920554(Q5U3Z7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920647(Q5U2X8) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920585(Q7TP24) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-779677(P05426) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-915744(P02454) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|agonist:Insulin was shown to increase or decrease GLUT4 protein interactions in specific cases.|comment:"Insulin decreased GLUT4 interactions with the following proteins: Q9ER30 (Sarcosin), P09527 (Rab-7), O88960 (N-ethylmaleimide sensitive), P09456 (PKA I regulatory subunit), P27881 (Hexokinase type II), P07872 (Acyl-coenzyme A oxidase), Q6DGF1 (Isocitrate dehydrogenase), Q9EQX9 (Ubiquitin-conjugating), Q63446 (Polyubiquitin), P24268 (Cathepsin D), Q91XW0 (Heat shock protein 86), Q5FVH0 (unknown), P58405 (Striatin 3), Q62667 (Major vault protein), Q66H50 (unknown), Q09167 (splicing factor), Q9JHU5 (Arfaptin 1)."|comment:"Insulin increased GLUT4 interaction with the following proteins:Q9Z1P2 (R-actinin-1), P45592 (Cofilin), Q9QXQ0 (R-actinin-4), P26473 (ADP-ribosylation factor), P26437 (ADP-ribosylation factor),   Q7TNP1 (Basigin 2), Q6P6R2 (Dihydrolipoamide dehydrogenase),   P04797 (GAPDH), Q63081 (Protein disulfide isomerase), P29457 (47 kDa heat shock protein), Q9R1J8 (Leprecan), O88638 (Putative eps protein),   Q64375 (Synaptonemal complex)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:NDPK - Interactions involving proteins containing InterPro domain IPR001564, Nucleoside diphosphate kinase, core.	taxid:10116(rat-l6)|taxid:10116(Rattus norvegicus)	-	2006/02/15	2021/11/30	rogid:PbFY2lfrty8yw40Jq7ShR7xfuV410116	rogid:q0aq7rS7wJScUCaWzdIxdkde2V810116	intact-crc:44F3A2176D02515F|rigid:9RVm0UBcqQF4k06RGKO89Bg16Q8	false	myc tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P19357	uniprotkb:P29314	intact:EBI-915426|uniprotkb:P97900|ensembl:ENSRNOP00000023256	intact:EBI-917123|uniprotkb:Q6P9W7|ensembl:ENSRNOP00000074779|ensembl:ENSRNOP00000075462	psi-mi:glut4_rat(display_long)|uniprotkb:Glucose transporter type 4, insulin-responsive(gene name synonym)|uniprotkb:Slc2a4(gene name)|psi-mi:Slc2a4(display_short)|uniprotkb:Glut4(gene name synonym)	psi-mi:rs9_rat(display_long)|uniprotkb:Rps9(gene name)|psi-mi:Rps9(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Foster et al. (2006)	pubmed:16396496|mint:MINT-5218203	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-921030	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2711|refseq:NP_036883.1|refseq:XP_006246658.1|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007611"(learning or memory)|go:"GO:0007614"(short-term memory)|go:"GO:0007616"(long-term memory)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010021"(amylopectin biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031550"(positive regulation of brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044381"(glucose import in response to insulin stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046323"(glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0098694"(regulation of synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0098793"(presynapse)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002441("Glucose transporter, type 4 (GLUT4)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-189200|ensembl:ENSRNOG00000017226(gene)|ensembl:ENSRNOT00000023256(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)	rgd:619889|refseq:NP_112370.2|refseq:NP_001300864.1|ensembl:ENSRNOG00000058909(gene)|ensembl:ENSRNOT00000086622(transcript)|ensembl:ENSRNOT00000090819(transcript)|go:"GO:0003735"(structural constituent of ribosome)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006412"(translation)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0015935"(small ribosomal subunit)|go:"GO:0019843"(rRNA binding)|go:"GO:0022626"(cytosolic ribosome)|go:"GO:0022627"(cytosolic small ribosomal subunit)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045202"(synapse)|go:"GO:0045903"(positive regulation of translational fidelity)|go:"GO:1990904"(ribonucleoprotein complex)|go:"GO:1990932"(5.8S rRNA binding)|interpro:IPR001912(Ribosomal protein S4)|interpro:IPR002942(RNA-binding S4)|interpro:IPR005710(Ribosomal protein S4/S9, eukaryotic/archaeal)|interpro:IPR018079|interpro:IPR022801|interpro:IPR036986|reactome:R-RNO-156827|reactome:R-RNO-1799339|reactome:R-RNO-6791226|reactome:R-RNO-72649|reactome:R-RNO-72689|reactome:R-RNO-72695|reactome:R-RNO-72702|reactome:R-RNO-72706|reactome:R-RNO-975956|reactome:R-RNO-975957	-	-	-	caution:"The participant EBI-349571(P68370) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919386(Q7TP47) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920972(Q5XIP9) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-916419(P11980) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919578(Q8R491) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920554(Q5U3Z7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920647(Q5U2X8) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920585(Q7TP24) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-779677(P05426) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-915744(P02454) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|agonist:Insulin was shown to increase or decrease GLUT4 protein interactions in specific cases.|comment:"Insulin decreased GLUT4 interactions with the following proteins: Q9ER30 (Sarcosin), P09527 (Rab-7), O88960 (N-ethylmaleimide sensitive), P09456 (PKA I regulatory subunit), P27881 (Hexokinase type II), P07872 (Acyl-coenzyme A oxidase), Q6DGF1 (Isocitrate dehydrogenase), Q9EQX9 (Ubiquitin-conjugating), Q63446 (Polyubiquitin), P24268 (Cathepsin D), Q91XW0 (Heat shock protein 86), Q5FVH0 (unknown), P58405 (Striatin 3), Q62667 (Major vault protein), Q66H50 (unknown), Q09167 (splicing factor), Q9JHU5 (Arfaptin 1)."|comment:"Insulin increased GLUT4 interaction with the following proteins:Q9Z1P2 (R-actinin-1), P45592 (Cofilin), Q9QXQ0 (R-actinin-4), P26473 (ADP-ribosylation factor), P26437 (ADP-ribosylation factor),   Q7TNP1 (Basigin 2), Q6P6R2 (Dihydrolipoamide dehydrogenase),   P04797 (GAPDH), Q63081 (Protein disulfide isomerase), P29457 (47 kDa heat shock protein), Q9R1J8 (Leprecan), O88638 (Putative eps protein),   Q64375 (Synaptonemal complex)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:NDPK - Interactions involving proteins containing InterPro domain IPR001564, Nucleoside diphosphate kinase, core.	taxid:10116(rat-l6)|taxid:10116(Rattus norvegicus)	-	2006/02/15	2021/11/30	rogid:PbFY2lfrty8yw40Jq7ShR7xfuV410116	rogid:PGNjkKMs8bMMOSOz2AQvwuCvO1A10116	intact-crc:44F3A2176D02515F|rigid:9RVm0UBcqQF4k06RGKO89Bg16Q8	false	myc tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P19357	uniprotkb:Q63507	intact:EBI-915426|uniprotkb:P97900|ensembl:ENSRNOP00000023256	intact:EBI-918595	psi-mi:glut4_rat(display_long)|uniprotkb:Glucose transporter type 4, insulin-responsive(gene name synonym)|uniprotkb:Slc2a4(gene name)|psi-mi:Slc2a4(display_short)|uniprotkb:Glut4(gene name synonym)	psi-mi:rl14_rat(display_long)|uniprotkb:Rpl14(gene name)|psi-mi:Rpl14(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Foster et al. (2006)	pubmed:16396496|mint:MINT-5218203	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-921030	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2711|refseq:NP_036883.1|refseq:XP_006246658.1|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007611"(learning or memory)|go:"GO:0007614"(short-term memory)|go:"GO:0007616"(long-term memory)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010021"(amylopectin biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031550"(positive regulation of brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044381"(glucose import in response to insulin stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046323"(glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0098694"(regulation of synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0098793"(presynapse)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002441("Glucose transporter, type 4 (GLUT4)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-189200|ensembl:ENSRNOG00000017226(gene)|ensembl:ENSRNOT00000023256(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)	rgd:621180|interpro:IPR002784(Ribosomal protein L14)|interpro:IPR014722(Translation protein SH3-like, subgroup)|interpro:IPR008991(Translation protein SH3-like)|interpro:IPR039660|interpro:IPR041985|reactome:R-RNO-156827|reactome:R-RNO-1799339|reactome:R-RNO-6791226|reactome:R-RNO-72689|reactome:R-RNO-72706|reactome:R-RNO-975956|reactome:R-RNO-975957|go:"GO:0003723"(RNA binding)|go:"GO:0003735"(structural constituent of ribosome)|go:"GO:0006364"(rRNA processing)|go:"GO:0006412"(translation)|go:"GO:0014069"(postsynaptic density)|go:"GO:0022625"(cytosolic large ribosomal subunit)|go:"GO:0022626"(cytosolic ribosome)|go:"GO:0042273"(ribosomal large subunit biogenesis)	-	-	-	caution:"The participant EBI-349571(P68370) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919386(Q7TP47) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920972(Q5XIP9) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-916419(P11980) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919578(Q8R491) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920554(Q5U3Z7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920647(Q5U2X8) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920585(Q7TP24) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-779677(P05426) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-915744(P02454) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|agonist:Insulin was shown to increase or decrease GLUT4 protein interactions in specific cases.|comment:"Insulin decreased GLUT4 interactions with the following proteins: Q9ER30 (Sarcosin), P09527 (Rab-7), O88960 (N-ethylmaleimide sensitive), P09456 (PKA I regulatory subunit), P27881 (Hexokinase type II), P07872 (Acyl-coenzyme A oxidase), Q6DGF1 (Isocitrate dehydrogenase), Q9EQX9 (Ubiquitin-conjugating), Q63446 (Polyubiquitin), P24268 (Cathepsin D), Q91XW0 (Heat shock protein 86), Q5FVH0 (unknown), P58405 (Striatin 3), Q62667 (Major vault protein), Q66H50 (unknown), Q09167 (splicing factor), Q9JHU5 (Arfaptin 1)."|comment:"Insulin increased GLUT4 interaction with the following proteins:Q9Z1P2 (R-actinin-1), P45592 (Cofilin), Q9QXQ0 (R-actinin-4), P26473 (ADP-ribosylation factor), P26437 (ADP-ribosylation factor),   Q7TNP1 (Basigin 2), Q6P6R2 (Dihydrolipoamide dehydrogenase),   P04797 (GAPDH), Q63081 (Protein disulfide isomerase), P29457 (47 kDa heat shock protein), Q9R1J8 (Leprecan), O88638 (Putative eps protein),   Q64375 (Synaptonemal complex)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:NDPK - Interactions involving proteins containing InterPro domain IPR001564, Nucleoside diphosphate kinase, core.	taxid:10116(rat-l6)|taxid:10116(Rattus norvegicus)	-	2006/02/15	2021/11/30	rogid:PbFY2lfrty8yw40Jq7ShR7xfuV410116	rogid:7EpTXwPZX5VtuaSAc2sPbRMsbD410116	intact-crc:44F3A2176D02515F|rigid:9RVm0UBcqQF4k06RGKO89Bg16Q8	false	myc tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P19357	uniprotkb:Q63448	intact:EBI-915426|uniprotkb:P97900|ensembl:ENSRNOP00000023256	intact:EBI-918583	psi-mi:glut4_rat(display_long)|uniprotkb:Glucose transporter type 4, insulin-responsive(gene name synonym)|uniprotkb:Slc2a4(gene name)|psi-mi:Slc2a4(display_short)|uniprotkb:Glut4(gene name synonym)	psi-mi:acox3_rat(display_long)|uniprotkb:Pristanoyl-CoA oxidase(gene name synonym)|uniprotkb:Branched-chain acyl-CoA oxidase(gene name synonym)|uniprotkb:Acox3(gene name)|psi-mi:Acox3(display_short)|uniprotkb:Prcox(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Foster et al. (2006)	pubmed:16396496|mint:MINT-5218203	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-921030	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2711|refseq:NP_036883.1|refseq:XP_006246658.1|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007611"(learning or memory)|go:"GO:0007614"(short-term memory)|go:"GO:0007616"(long-term memory)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010021"(amylopectin biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031550"(positive regulation of brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044381"(glucose import in response to insulin stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046323"(glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0098694"(regulation of synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0098793"(presynapse)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002441("Glucose transporter, type 4 (GLUT4)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-189200|ensembl:ENSRNOG00000017226(gene)|ensembl:ENSRNOT00000023256(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)	rgd:69245|refseq:NP_445791.1|interpro:IPR006091(Acyl-CoA dehydrogenase/oxidase, central region)|interpro:IPR012258(Acyl-CoA oxidase)|interpro:IPR002655(Acyl-CoA oxidase, C-terminal)|interpro:IPR009075(Acyl-CoA dehydrogenase/oxidase C-terminal)|interpro:IPR009100(Acyl-CoA dehydrogenase/oxidase, middle and N-terminal)|interpro:IPR034171|interpro:IPR036250|reactome:R-RNO-389887|reactome:R-RNO-9033241|go:"GO:0003997"(acyl-CoA oxidase activity)|go:"GO:0005504"(fatty acid binding)|go:"GO:0005777"(peroxisome)|go:"GO:0016402"(pristanoyl-CoA oxidase activity)|go:"GO:0033540"(fatty acid beta-oxidation using acyl-CoA oxidase)|go:"GO:0050660"(flavin adenine dinucleotide binding)|go:"GO:0055088"(lipid homeostasis)|go:"GO:0071949"(FAD binding)	-	-	-	caution:"The participant EBI-349571(P68370) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919386(Q7TP47) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920972(Q5XIP9) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-916419(P11980) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919578(Q8R491) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920554(Q5U3Z7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920647(Q5U2X8) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920585(Q7TP24) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-779677(P05426) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-915744(P02454) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|agonist:Insulin was shown to increase or decrease GLUT4 protein interactions in specific cases.|comment:"Insulin decreased GLUT4 interactions with the following proteins: Q9ER30 (Sarcosin), P09527 (Rab-7), O88960 (N-ethylmaleimide sensitive), P09456 (PKA I regulatory subunit), P27881 (Hexokinase type II), P07872 (Acyl-coenzyme A oxidase), Q6DGF1 (Isocitrate dehydrogenase), Q9EQX9 (Ubiquitin-conjugating), Q63446 (Polyubiquitin), P24268 (Cathepsin D), Q91XW0 (Heat shock protein 86), Q5FVH0 (unknown), P58405 (Striatin 3), Q62667 (Major vault protein), Q66H50 (unknown), Q09167 (splicing factor), Q9JHU5 (Arfaptin 1)."|comment:"Insulin increased GLUT4 interaction with the following proteins:Q9Z1P2 (R-actinin-1), P45592 (Cofilin), Q9QXQ0 (R-actinin-4), P26473 (ADP-ribosylation factor), P26437 (ADP-ribosylation factor),   Q7TNP1 (Basigin 2), Q6P6R2 (Dihydrolipoamide dehydrogenase),   P04797 (GAPDH), Q63081 (Protein disulfide isomerase), P29457 (47 kDa heat shock protein), Q9R1J8 (Leprecan), O88638 (Putative eps protein),   Q64375 (Synaptonemal complex)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:NDPK - Interactions involving proteins containing InterPro domain IPR001564, Nucleoside diphosphate kinase, core.	taxid:10116(rat-l6)|taxid:10116(Rattus norvegicus)	-	2006/02/15	2021/11/30	rogid:PbFY2lfrty8yw40Jq7ShR7xfuV410116	rogid:oiOt845wL8kXIhP+AjhuzRrPGug10116	intact-crc:44F3A2176D02515F|rigid:9RVm0UBcqQF4k06RGKO89Bg16Q8	false	myc tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P19357	uniprotkb:P62982	intact:EBI-915426|uniprotkb:P97900|ensembl:ENSRNOP00000023256	intact:EBI-412946|uniprotkb:P02248|uniprotkb:P02249|uniprotkb:P02250|uniprotkb:Q29120|uniprotkb:Q63446|uniprotkb:Q91887|uniprotkb:Q91888|uniprotkb:P49664|uniprotkb:Q9D2W3|uniprotkb:P62989|ensembl:ENSRNOP00000005872|ensembl:ENSRNOP00000048664	psi-mi:glut4_rat(display_long)|uniprotkb:Glucose transporter type 4, insulin-responsive(gene name synonym)|uniprotkb:Slc2a4(gene name)|psi-mi:Slc2a4(display_short)|uniprotkb:Glut4(gene name synonym)	psi-mi:rs27a_rat(display_long)|uniprotkb:Rps27a(gene name)|psi-mi:Rps27a(display_short)|uniprotkb:Uba80(gene name synonym)|uniprotkb:Ubcep1(gene name synonym)|uniprotkb:Ubiquitin carboxyl extension protein 80(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Foster et al. (2006)	pubmed:16396496|mint:MINT-5218203	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-921030	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2711|refseq:NP_036883.1|refseq:XP_006246658.1|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007611"(learning or memory)|go:"GO:0007614"(short-term memory)|go:"GO:0007616"(long-term memory)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010021"(amylopectin biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031550"(positive regulation of brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044381"(glucose import in response to insulin stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046323"(glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0098694"(regulation of synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0098793"(presynapse)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002441("Glucose transporter, type 4 (GLUT4)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-189200|ensembl:ENSRNOG00000017226(gene)|ensembl:ENSRNOT00000023256(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)	rgd:6489478|refseq:NP_112375.1|refseq:NP_001292372.1|ensembl:ENSRNOG00000004426(gene)|ensembl:ENSRNOG00000034246(gene)|ensembl:ENSRNOT00000005872(transcript)|ensembl:ENSRNOT00000049535(transcript)|go:"GO:0003735"(structural constituent of ribosome)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006412"(translation)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019941"(modification-dependent protein catabolic process)|go:"GO:0022626"(cytosolic ribosome)|go:"GO:0022627"(cytosolic small ribosomal subunit)|go:"GO:0031386"(protein tag)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0046872"(metal ion binding)|interpro:IPR000626(Ubiquitin)|interpro:IPR002906(Ribosomal protein S27a)|interpro:IPR011332(Ribosomal protein, zinc-binding)|interpro:IPR019954|interpro:IPR019956|interpro:IPR029071|interpro:IPR038582|reactome:R-RNO-110312|reactome:R-RNO-110314|reactome:R-RNO-110320|reactome:R-RNO-1169091|reactome:R-RNO-1234176|reactome:R-RNO-1253288|reactome:R-RNO-1295596|reactome:R-RNO-1358803|reactome:R-RNO-156827|reactome:R-RNO-168638|reactome:R-RNO-174048|reactome:R-RNO-174084|reactome:R-RNO-174154|reactome:R-RNO-174178|reactome:R-RNO-174184|reactome:R-RNO-179409|reactome:R-RNO-1799339|reactome:R-RNO-182971|reactome:R-RNO-187577|reactome:R-RNO-195253|reactome:R-RNO-201681|reactome:R-RNO-205043|reactome:R-RNO-209543|reactome:R-RNO-209560|reactome:R-RNO-2122948|reactome:R-RNO-2173788|reactome:R-RNO-2173791|reactome:R-RNO-2173795|reactome:R-RNO-2173796|reactome:R-RNO-2467813|reactome:R-RNO-2559580|reactome:R-RNO-2559582|reactome:R-RNO-2559585|reactome:R-RNO-2565942|reactome:R-RNO-2672351|reactome:R-RNO-3134975|reactome:R-RNO-349425|reactome:R-RNO-382556|reactome:R-RNO-445989|reactome:R-RNO-450302|reactome:R-RNO-450321|reactome:R-RNO-3769402|reactome:R-RNO-450408|reactome:R-RNO-4608870|reactome:R-RNO-4641257|reactome:R-RNO-4641258|reactome:R-RNO-4641263|reactome:R-RNO-532668|reactome:R-RNO-5357905|reactome:R-RNO-5357956|reactome:R-RNO-5358346|reactome:R-RNO-5607761|reactome:R-RNO-5610780|reactome:R-RNO-5610785|reactome:R-RNO-5632684|reactome:R-RNO-5654726|reactome:R-RNO-5654727|reactome:R-RNO-5654732|reactome:R-RNO-5654733|reactome:R-RNO-5655862|reactome:R-RNO-5656121|reactome:R-RNO-5656169|reactome:R-RNO-5658442|reactome:R-RNO-5668541|reactome:R-RNO-5675221|reactome:R-RNO-5675482|reactome:R-RNO-5676590|reactome:R-RNO-5685942|reactome:R-RNO-5687128|reactome:R-RNO-5689603|reactome:R-RNO-5689877|reactome:R-RNO-5689880|reactome:R-RNO-5689896|reactome:R-RNO-5689901|reactome:R-RNO-5693565|reactome:R-RNO-5696394|reactome:R-RNO-5696395|reactome:R-RNO-5696397|reactome:R-RNO-5696400|reactome:R-RNO-6781823|reactome:R-RNO-6782135|reactome:R-RNO-6782210|reactome:R-RNO-6783310|reactome:R-RNO-6791226|reactome:R-RNO-6804756|reactome:R-RNO-6804757|reactome:R-RNO-6804760|reactome:R-RNO-6807004|reactome:R-RNO-68827|reactome:R-RNO-68949|reactome:R-RNO-69017|reactome:R-RNO-69231|reactome:R-RNO-69481|reactome:R-RNO-69541|reactome:R-RNO-69601|reactome:R-RNO-72649|reactome:R-RNO-72689|reactome:R-RNO-72695|reactome:R-RNO-72702|reactome:R-RNO-72706|reactome:R-RNO-75815|reactome:R-RNO-8849469|reactome:R-RNO-8852276|reactome:R-RNO-8854050|reactome:R-RNO-8856825|reactome:R-RNO-8856828|reactome:R-RNO-8863795|reactome:R-RNO-8866652|reactome:R-RNO-8866654|reactome:R-RNO-8932339|reactome:R-RNO-8939236|reactome:R-RNO-8941858|reactome:R-RNO-8948751|reactome:R-RNO-8951664|reactome:R-RNO-901032|reactome:R-RNO-9013507|reactome:R-RNO-9020702|reactome:R-RNO-9033241|reactome:R-RNO-912631|reactome:R-RNO-917729|reactome:R-RNO-917937|reactome:R-RNO-937042|reactome:R-RNO-937072|reactome:R-RNO-9645460|reactome:R-RNO-9646399|reactome:R-RNO-9648002|reactome:R-RNO-9664873|reactome:R-RNO-9705462|reactome:R-RNO-9706369|reactome:R-RNO-975163|reactome:R-RNO-975956|reactome:R-RNO-975957|reactome:R-RNO-983168|reactome:R-RNO-8948747	-	-	-	caution:"The participant EBI-349571(P68370) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919386(Q7TP47) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920972(Q5XIP9) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-916419(P11980) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919578(Q8R491) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920554(Q5U3Z7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920647(Q5U2X8) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920585(Q7TP24) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-779677(P05426) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-915744(P02454) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|agonist:Insulin was shown to increase or decrease GLUT4 protein interactions in specific cases.|comment:"Insulin decreased GLUT4 interactions with the following proteins: Q9ER30 (Sarcosin), P09527 (Rab-7), O88960 (N-ethylmaleimide sensitive), P09456 (PKA I regulatory subunit), P27881 (Hexokinase type II), P07872 (Acyl-coenzyme A oxidase), Q6DGF1 (Isocitrate dehydrogenase), Q9EQX9 (Ubiquitin-conjugating), Q63446 (Polyubiquitin), P24268 (Cathepsin D), Q91XW0 (Heat shock protein 86), Q5FVH0 (unknown), P58405 (Striatin 3), Q62667 (Major vault protein), Q66H50 (unknown), Q09167 (splicing factor), Q9JHU5 (Arfaptin 1)."|comment:"Insulin increased GLUT4 interaction with the following proteins:Q9Z1P2 (R-actinin-1), P45592 (Cofilin), Q9QXQ0 (R-actinin-4), P26473 (ADP-ribosylation factor), P26437 (ADP-ribosylation factor),   Q7TNP1 (Basigin 2), Q6P6R2 (Dihydrolipoamide dehydrogenase),   P04797 (GAPDH), Q63081 (Protein disulfide isomerase), P29457 (47 kDa heat shock protein), Q9R1J8 (Leprecan), O88638 (Putative eps protein),   Q64375 (Synaptonemal complex)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:NDPK - Interactions involving proteins containing InterPro domain IPR001564, Nucleoside diphosphate kinase, core.	taxid:10116(rat-l6)|taxid:10116(Rattus norvegicus)	-	2006/02/15	2021/11/30	rogid:PbFY2lfrty8yw40Jq7ShR7xfuV410116	rogid:AkJxTgRFL5RT5jWk5i3y4zX5tfA10116	intact-crc:44F3A2176D02515F|rigid:9RVm0UBcqQF4k06RGKO89Bg16Q8	false	myc tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P19357	uniprotkb:Q63377	intact:EBI-915426|uniprotkb:P97900|ensembl:ENSRNOP00000023256	intact:EBI-918577|ensembl:ENSRNOP00000015475	psi-mi:glut4_rat(display_long)|uniprotkb:Glucose transporter type 4, insulin-responsive(gene name synonym)|uniprotkb:Slc2a4(gene name)|psi-mi:Slc2a4(display_short)|uniprotkb:Glut4(gene name synonym)	psi-mi:at1b3_rat(display_long)|uniprotkb:Sodium/potassium-dependent ATPase subunit beta-3(gene name synonym)|uniprotkb:Atp1b3(gene name)|psi-mi:Atp1b3(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Foster et al. (2006)	pubmed:16396496|mint:MINT-5218203	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-921030	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2711|refseq:NP_036883.1|refseq:XP_006246658.1|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007611"(learning or memory)|go:"GO:0007614"(short-term memory)|go:"GO:0007616"(long-term memory)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010021"(amylopectin biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031550"(positive regulation of brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044381"(glucose import in response to insulin stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046323"(glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0098694"(regulation of synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0098793"(presynapse)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002441("Glucose transporter, type 4 (GLUT4)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-189200|ensembl:ENSRNOG00000017226(gene)|ensembl:ENSRNOT00000023256(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)	refseq:NP_037045.1|rgd:2172|ensembl:ENSRNOG00000011501(gene)|ensembl:ENSRNOT00000015476(transcript)|go:"GO:0001671"(ATPase activator activity)|go:"GO:0005391"("P-type sodium:potassium-exchanging transporter activity")|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005890"("sodium:potassium-exchanging ATPase complex")|go:"GO:0005901"(caveola)|go:"GO:0006813"(potassium ion transport)|go:"GO:0006814"(sodium ion transport)|go:"GO:0006883"(cellular sodium ion homeostasis)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0030001"(metal ion transport)|go:"GO:0030007"(cellular potassium ion homeostasis)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0032781"(positive regulation of ATP-dependent activity)|go:"GO:0035725"(sodium ion transmembrane transport)|go:"GO:0036126"(sperm flagellum)|go:"GO:0036376"(sodium ion export across plasma membrane)|go:"GO:0042470"(melanosome)|go:"GO:0050821"(protein stabilization)|go:"GO:0051117"(ATPase binding)|go:"GO:0071805"(potassium ion transmembrane transport)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0086009"(membrane repolarization)|go:"GO:1901018"(positive regulation of potassium ion transmembrane transporter activity)|go:"GO:1903278"(positive regulation of sodium ion export across plasma membrane)|go:"GO:1903288"(positive regulation of potassium ion import across plasma membrane)|go:"GO:1990573"(potassium ion import across plasma membrane)|interpro:IPR000402(ATPase, P-type cation exchange, beta subunit)|interpro:IPR038702|reactome:R-RNO-210991|reactome:R-RNO-5578775|reactome:R-RNO-936837	-	-	-	caution:"The participant EBI-349571(P68370) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919386(Q7TP47) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920972(Q5XIP9) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-916419(P11980) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919578(Q8R491) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920554(Q5U3Z7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920647(Q5U2X8) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920585(Q7TP24) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-779677(P05426) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-915744(P02454) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|agonist:Insulin was shown to increase or decrease GLUT4 protein interactions in specific cases.|comment:"Insulin decreased GLUT4 interactions with the following proteins: Q9ER30 (Sarcosin), P09527 (Rab-7), O88960 (N-ethylmaleimide sensitive), P09456 (PKA I regulatory subunit), P27881 (Hexokinase type II), P07872 (Acyl-coenzyme A oxidase), Q6DGF1 (Isocitrate dehydrogenase), Q9EQX9 (Ubiquitin-conjugating), Q63446 (Polyubiquitin), P24268 (Cathepsin D), Q91XW0 (Heat shock protein 86), Q5FVH0 (unknown), P58405 (Striatin 3), Q62667 (Major vault protein), Q66H50 (unknown), Q09167 (splicing factor), Q9JHU5 (Arfaptin 1)."|comment:"Insulin increased GLUT4 interaction with the following proteins:Q9Z1P2 (R-actinin-1), P45592 (Cofilin), Q9QXQ0 (R-actinin-4), P26473 (ADP-ribosylation factor), P26437 (ADP-ribosylation factor),   Q7TNP1 (Basigin 2), Q6P6R2 (Dihydrolipoamide dehydrogenase),   P04797 (GAPDH), Q63081 (Protein disulfide isomerase), P29457 (47 kDa heat shock protein), Q9R1J8 (Leprecan), O88638 (Putative eps protein),   Q64375 (Synaptonemal complex)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:NDPK - Interactions involving proteins containing InterPro domain IPR001564, Nucleoside diphosphate kinase, core.	taxid:10116(rat-l6)|taxid:10116(Rattus norvegicus)	-	2006/02/15	2021/11/30	rogid:PbFY2lfrty8yw40Jq7ShR7xfuV410116	rogid:GhcaevDyyzsnN/096rE3vq3hBOI10116	intact-crc:44F3A2176D02515F|rigid:9RVm0UBcqQF4k06RGKO89Bg16Q8	false	myc tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P19357	uniprotkb:Q63347	intact:EBI-915426|uniprotkb:P97900|ensembl:ENSRNOP00000023256	intact:EBI-918567|uniprotkb:Q62690|uniprotkb:Q6P7R9	psi-mi:glut4_rat(display_long)|uniprotkb:Glucose transporter type 4, insulin-responsive(gene name synonym)|uniprotkb:Slc2a4(gene name)|psi-mi:Slc2a4(display_short)|uniprotkb:Glut4(gene name synonym)	psi-mi:prs7_rat(display_long)|uniprotkb:Proteasome 26S subunit ATPase 2(gene name synonym)|uniprotkb:Protein MSS1(gene name synonym)|uniprotkb:Psmc2(gene name)|psi-mi:Psmc2(display_short)|uniprotkb:Mss1(gene name synonym)|uniprotkb:26S proteasome AAA-ATPase subunit RPT1(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Foster et al. (2006)	pubmed:16396496|mint:MINT-5218203	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-921030	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2711|refseq:NP_036883.1|refseq:XP_006246658.1|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007611"(learning or memory)|go:"GO:0007614"(short-term memory)|go:"GO:0007616"(long-term memory)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010021"(amylopectin biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031550"(positive regulation of brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044381"(glucose import in response to insulin stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046323"(glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0098694"(regulation of synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0098793"(presynapse)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002441("Glucose transporter, type 4 (GLUT4)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-189200|ensembl:ENSRNOG00000017226(gene)|ensembl:ENSRNOT00000023256(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)	rgd:3428|refseq:NP_150239.1|interpro:IPR005937(26S proteasome subunit P45)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR003959(AAA ATPase, core)|interpro:IPR003960(AAA ATPase, conserved site)|go:"GO:0000502"(proteasome complex)|go:"GO:0000932"(P-body)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0008540"(proteasome regulatory particle, base subcomplex)|go:"GO:0017025"(TBP-class protein binding)|go:"GO:0022624"(proteasome accessory complex)|go:"GO:0036402"(proteasome-activating activity)|go:"GO:0043197"(dendritic spine)|go:"GO:0045899"(positive regulation of RNA polymerase II transcription preinitiation complex assembly)|go:"GO:0140296"(general transcription initiation factor binding)|reactome:R-RNO-8932339|interpro:IPR027417|rcsb pdb:6EPC|rcsb pdb:6EPD|rcsb pdb:6EPE|rcsb pdb:6EPF|interpro:IPR035245|interpro:IPR041569|reactome:R-RNO-174084|reactome:R-RNO-5689603|reactome:R-RNO-5689880|reactome:R-RNO-6798695|reactome:R-RNO-68827|reactome:R-RNO-8951664|reactome:R-RNO-1169091|reactome:R-RNO-1234176|reactome:R-RNO-1236978|reactome:R-RNO-174154|reactome:R-RNO-174178|reactome:R-RNO-174184|reactome:R-RNO-187577|reactome:R-RNO-195253|reactome:R-RNO-2467813|reactome:R-RNO-349425|reactome:R-RNO-350562|reactome:R-RNO-382556|reactome:R-RNO-450408|reactome:R-RNO-4608870|reactome:R-RNO-4641257|reactome:R-RNO-4641258|reactome:R-RNO-5358346|reactome:R-RNO-5607761|reactome:R-RNO-5610780|reactome:R-RNO-5610785|reactome:R-RNO-5632684|reactome:R-RNO-5658442|reactome:R-RNO-5668541|reactome:R-RNO-5676590|reactome:R-RNO-5687128|reactome:R-RNO-68949|reactome:R-RNO-69017|reactome:R-RNO-69481|reactome:R-RNO-69601|reactome:R-RNO-75815|reactome:R-RNO-8852276|reactome:R-RNO-8854050|reactome:R-RNO-8939236|reactome:R-RNO-8941858|reactome:R-RNO-8948751|reactome:R-RNO-983168	-	-	-	caution:"The participant EBI-349571(P68370) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919386(Q7TP47) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920972(Q5XIP9) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-916419(P11980) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919578(Q8R491) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920554(Q5U3Z7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920647(Q5U2X8) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920585(Q7TP24) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-779677(P05426) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-915744(P02454) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|agonist:Insulin was shown to increase or decrease GLUT4 protein interactions in specific cases.|comment:"Insulin decreased GLUT4 interactions with the following proteins: Q9ER30 (Sarcosin), P09527 (Rab-7), O88960 (N-ethylmaleimide sensitive), P09456 (PKA I regulatory subunit), P27881 (Hexokinase type II), P07872 (Acyl-coenzyme A oxidase), Q6DGF1 (Isocitrate dehydrogenase), Q9EQX9 (Ubiquitin-conjugating), Q63446 (Polyubiquitin), P24268 (Cathepsin D), Q91XW0 (Heat shock protein 86), Q5FVH0 (unknown), P58405 (Striatin 3), Q62667 (Major vault protein), Q66H50 (unknown), Q09167 (splicing factor), Q9JHU5 (Arfaptin 1)."|comment:"Insulin increased GLUT4 interaction with the following proteins:Q9Z1P2 (R-actinin-1), P45592 (Cofilin), Q9QXQ0 (R-actinin-4), P26473 (ADP-ribosylation factor), P26437 (ADP-ribosylation factor),   Q7TNP1 (Basigin 2), Q6P6R2 (Dihydrolipoamide dehydrogenase),   P04797 (GAPDH), Q63081 (Protein disulfide isomerase), P29457 (47 kDa heat shock protein), Q9R1J8 (Leprecan), O88638 (Putative eps protein),   Q64375 (Synaptonemal complex)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:NDPK - Interactions involving proteins containing InterPro domain IPR001564, Nucleoside diphosphate kinase, core.	taxid:10116(rat-l6)|taxid:10116(Rattus norvegicus)	-	2006/02/15	2021/11/30	rogid:PbFY2lfrty8yw40Jq7ShR7xfuV410116	rogid:mkLED0sa4m4p2Q/87z8Fe2h8J0410116	intact-crc:44F3A2176D02515F|rigid:9RVm0UBcqQF4k06RGKO89Bg16Q8	false	myc tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P19357	uniprotkb:Q63321	intact:EBI-915426|uniprotkb:P97900|ensembl:ENSRNOP00000023256	intact:EBI-918559	psi-mi:glut4_rat(display_long)|uniprotkb:Glucose transporter type 4, insulin-responsive(gene name synonym)|uniprotkb:Slc2a4(gene name)|psi-mi:Slc2a4(display_short)|uniprotkb:Glut4(gene name synonym)	psi-mi:plod1_rat(display_long)|uniprotkb:Lysyl hydroxylase 1(gene name synonym)|uniprotkb:Plod1(gene name)|psi-mi:Plod1(display_short)|uniprotkb:Plod(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Foster et al. (2006)	pubmed:16396496|mint:MINT-5218203	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-921030	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2711|refseq:NP_036883.1|refseq:XP_006246658.1|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007611"(learning or memory)|go:"GO:0007614"(short-term memory)|go:"GO:0007616"(long-term memory)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010021"(amylopectin biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031550"(positive regulation of brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044381"(glucose import in response to insulin stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046323"(glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0098694"(regulation of synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0098793"(presynapse)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002441("Glucose transporter, type 4 (GLUT4)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-189200|ensembl:ENSRNOG00000017226(gene)|ensembl:ENSRNOT00000023256(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)	rgd:621382|interpro:IPR005123("2OG-Fe(II) oxygenase")|interpro:IPR006620(Prolyl 4-hydroxylase, alpha subunit)|interpro:IPR001006(Procollagen-lysine 5-dioxygenase)|interpro:IPR029044|go:"GO:0001666"(response to hypoxia)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0008198"(ferrous iron binding)|go:"GO:0008475"(procollagen-lysine 5-dioxygenase activity)|go:"GO:0008544"(epidermis development)|go:"GO:0017185"(peptidyl-lysine hydroxylation)|go:"GO:0030867"(rough endoplasmic reticulum membrane)|go:"GO:0031418"(L-ascorbic acid binding)|go:"GO:0032870"(cellular response to hormone stimulus)|go:"GO:0042277"(peptide binding)|go:"GO:1902494"(catalytic complex)|reactome:R-RNO-1650814	-	-	-	caution:"The participant EBI-349571(P68370) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919386(Q7TP47) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920972(Q5XIP9) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-916419(P11980) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919578(Q8R491) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920554(Q5U3Z7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920647(Q5U2X8) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920585(Q7TP24) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-779677(P05426) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-915744(P02454) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|agonist:Insulin was shown to increase or decrease GLUT4 protein interactions in specific cases.|comment:"Insulin decreased GLUT4 interactions with the following proteins: Q9ER30 (Sarcosin), P09527 (Rab-7), O88960 (N-ethylmaleimide sensitive), P09456 (PKA I regulatory subunit), P27881 (Hexokinase type II), P07872 (Acyl-coenzyme A oxidase), Q6DGF1 (Isocitrate dehydrogenase), Q9EQX9 (Ubiquitin-conjugating), Q63446 (Polyubiquitin), P24268 (Cathepsin D), Q91XW0 (Heat shock protein 86), Q5FVH0 (unknown), P58405 (Striatin 3), Q62667 (Major vault protein), Q66H50 (unknown), Q09167 (splicing factor), Q9JHU5 (Arfaptin 1)."|comment:"Insulin increased GLUT4 interaction with the following proteins:Q9Z1P2 (R-actinin-1), P45592 (Cofilin), Q9QXQ0 (R-actinin-4), P26473 (ADP-ribosylation factor), P26437 (ADP-ribosylation factor),   Q7TNP1 (Basigin 2), Q6P6R2 (Dihydrolipoamide dehydrogenase),   P04797 (GAPDH), Q63081 (Protein disulfide isomerase), P29457 (47 kDa heat shock protein), Q9R1J8 (Leprecan), O88638 (Putative eps protein),   Q64375 (Synaptonemal complex)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:NDPK - Interactions involving proteins containing InterPro domain IPR001564, Nucleoside diphosphate kinase, core.	taxid:10116(rat-l6)|taxid:10116(Rattus norvegicus)	-	2006/02/15	2021/11/30	rogid:PbFY2lfrty8yw40Jq7ShR7xfuV410116	rogid:HEsQciPZbZOtgY96mXUvZ+g/E8E10116	intact-crc:44F3A2176D02515F|rigid:9RVm0UBcqQF4k06RGKO89Bg16Q8	false	myc tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P19357	uniprotkb:Q63312	intact:EBI-915426|uniprotkb:P97900|ensembl:ENSRNOP00000023256	intact:EBI-918552	psi-mi:glut4_rat(display_long)|uniprotkb:Glucose transporter type 4, insulin-responsive(gene name synonym)|uniprotkb:Slc2a4(gene name)|psi-mi:Slc2a4(display_short)|uniprotkb:Glut4(gene name synonym)	psi-mi:phlb1_rat(display_long)|uniprotkb:Protein LL5-alpha(gene name synonym)|uniprotkb:Phldb1(gene name)|psi-mi:Phldb1(display_short)|uniprotkb:Ll5(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Foster et al. (2006)	pubmed:16396496|mint:MINT-5218203	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-921030	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2711|refseq:NP_036883.1|refseq:XP_006246658.1|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007611"(learning or memory)|go:"GO:0007614"(short-term memory)|go:"GO:0007616"(long-term memory)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010021"(amylopectin biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031550"(positive regulation of brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044381"(glucose import in response to insulin stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046323"(glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0098694"(regulation of synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0098793"(presynapse)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002441("Glucose transporter, type 4 (GLUT4)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-189200|ensembl:ENSRNOG00000017226(gene)|ensembl:ENSRNOT00000023256(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)	interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR001849(Pleckstrin-like)|rgd:620878|go:"GO:0010470"(regulation of gastrulation)|go:"GO:0010717"(regulation of epithelial to mesenchymal transition)|go:"GO:0045180"(basal cortex)|go:"GO:0070507"(regulation of microtubule cytoskeleton organization)|go:"GO:1904261"(positive regulation of basement membrane assembly involved in embryonic body morphogenesis)|interpro:IPR037810	-	-	-	caution:"The participant EBI-349571(P68370) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919386(Q7TP47) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920972(Q5XIP9) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-916419(P11980) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919578(Q8R491) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920554(Q5U3Z7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920647(Q5U2X8) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920585(Q7TP24) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-779677(P05426) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-915744(P02454) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|agonist:Insulin was shown to increase or decrease GLUT4 protein interactions in specific cases.|comment:"Insulin decreased GLUT4 interactions with the following proteins: Q9ER30 (Sarcosin), P09527 (Rab-7), O88960 (N-ethylmaleimide sensitive), P09456 (PKA I regulatory subunit), P27881 (Hexokinase type II), P07872 (Acyl-coenzyme A oxidase), Q6DGF1 (Isocitrate dehydrogenase), Q9EQX9 (Ubiquitin-conjugating), Q63446 (Polyubiquitin), P24268 (Cathepsin D), Q91XW0 (Heat shock protein 86), Q5FVH0 (unknown), P58405 (Striatin 3), Q62667 (Major vault protein), Q66H50 (unknown), Q09167 (splicing factor), Q9JHU5 (Arfaptin 1)."|comment:"Insulin increased GLUT4 interaction with the following proteins:Q9Z1P2 (R-actinin-1), P45592 (Cofilin), Q9QXQ0 (R-actinin-4), P26473 (ADP-ribosylation factor), P26437 (ADP-ribosylation factor),   Q7TNP1 (Basigin 2), Q6P6R2 (Dihydrolipoamide dehydrogenase),   P04797 (GAPDH), Q63081 (Protein disulfide isomerase), P29457 (47 kDa heat shock protein), Q9R1J8 (Leprecan), O88638 (Putative eps protein),   Q64375 (Synaptonemal complex)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:NDPK - Interactions involving proteins containing InterPro domain IPR001564, Nucleoside diphosphate kinase, core.	taxid:10116(rat-l6)|taxid:10116(Rattus norvegicus)	-	2006/02/15	2021/11/30	rogid:PbFY2lfrty8yw40Jq7ShR7xfuV410116	rogid:nyp+Xi5DhFzQrdos1jrMKESMFEg10116	intact-crc:44F3A2176D02515F|rigid:9RVm0UBcqQF4k06RGKO89Bg16Q8	false	myc tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P19357	uniprotkb:Q63258	intact:EBI-915426|uniprotkb:P97900|ensembl:ENSRNOP00000023256	intact:EBI-918522|uniprotkb:Q63026|uniprotkb:Q5HZX9|uniprotkb:Q63027|ensembl:ENSRNOP00000058370	psi-mi:glut4_rat(display_long)|uniprotkb:Glucose transporter type 4, insulin-responsive(gene name synonym)|uniprotkb:Slc2a4(gene name)|psi-mi:Slc2a4(display_short)|uniprotkb:Glut4(gene name synonym)	psi-mi:ita7_rat(display_long)|uniprotkb:H36-alpha7(gene name synonym)|uniprotkb:Itga7(gene name)|psi-mi:Itga7(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Foster et al. (2006)	pubmed:16396496|mint:MINT-5218203	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-921030	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2711|refseq:NP_036883.1|refseq:XP_006246658.1|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007611"(learning or memory)|go:"GO:0007614"(short-term memory)|go:"GO:0007616"(long-term memory)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010021"(amylopectin biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031550"(positive regulation of brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044381"(glucose import in response to insulin stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046323"(glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0098694"(regulation of synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0098793"(presynapse)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002441("Glucose transporter, type 4 (GLUT4)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-189200|ensembl:ENSRNOG00000017226(gene)|ensembl:ENSRNOT00000023256(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)	rgd:71022|refseq:NP_110469.1|ensembl:ENSRNOG00000007905(gene)|ensembl:ENSRNOT00000061657(transcript)|go:"GO:0005178"(integrin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005927"(muscle tendon junction)|go:"GO:0007155"(cell adhesion)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0007519"(skeletal muscle tissue development)|go:"GO:0008305"(integrin complex)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0009986"(cell surface)|go:"GO:0016477"(cell migration)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0034677"(integrin alpha7-beta1 complex)|go:"GO:0035987"(endodermal cell differentiation)|go:"GO:0042383"(sarcolemma)|go:"GO:0043236"(laminin binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0048514"(blood vessel morphogenesis)|go:"GO:0050839"(cell adhesion molecule binding)|interpro:IPR000413(Integrins alpha chain)|interpro:IPR013517(FG-GAP)|interpro:IPR013519(Integrin alpha beta-propellor)|interpro:IPR013649(Integrin alpha-2)|interpro:IPR018184|interpro:IPR028994|interpro:IPR032695|reactome:R-RNO-3000157|reactome:R-RNO-3000178	-	-	-	caution:"The participant EBI-349571(P68370) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919386(Q7TP47) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920972(Q5XIP9) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-916419(P11980) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919578(Q8R491) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920554(Q5U3Z7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920647(Q5U2X8) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920585(Q7TP24) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-779677(P05426) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-915744(P02454) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|agonist:Insulin was shown to increase or decrease GLUT4 protein interactions in specific cases.|comment:"Insulin decreased GLUT4 interactions with the following proteins: Q9ER30 (Sarcosin), P09527 (Rab-7), O88960 (N-ethylmaleimide sensitive), P09456 (PKA I regulatory subunit), P27881 (Hexokinase type II), P07872 (Acyl-coenzyme A oxidase), Q6DGF1 (Isocitrate dehydrogenase), Q9EQX9 (Ubiquitin-conjugating), Q63446 (Polyubiquitin), P24268 (Cathepsin D), Q91XW0 (Heat shock protein 86), Q5FVH0 (unknown), P58405 (Striatin 3), Q62667 (Major vault protein), Q66H50 (unknown), Q09167 (splicing factor), Q9JHU5 (Arfaptin 1)."|comment:"Insulin increased GLUT4 interaction with the following proteins:Q9Z1P2 (R-actinin-1), P45592 (Cofilin), Q9QXQ0 (R-actinin-4), P26473 (ADP-ribosylation factor), P26437 (ADP-ribosylation factor),   Q7TNP1 (Basigin 2), Q6P6R2 (Dihydrolipoamide dehydrogenase),   P04797 (GAPDH), Q63081 (Protein disulfide isomerase), P29457 (47 kDa heat shock protein), Q9R1J8 (Leprecan), O88638 (Putative eps protein),   Q64375 (Synaptonemal complex)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:NDPK - Interactions involving proteins containing InterPro domain IPR001564, Nucleoside diphosphate kinase, core.	taxid:10116(rat-l6)|taxid:10116(Rattus norvegicus)	-	2006/02/15	2021/11/30	rogid:PbFY2lfrty8yw40Jq7ShR7xfuV410116	rogid:nLQlX5AgkN0g9Nv8+HrRtRoyAJw10116	intact-crc:44F3A2176D02515F|rigid:9RVm0UBcqQF4k06RGKO89Bg16Q8	false	myc tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P19357	uniprotkb:Q63151	intact:EBI-915426|uniprotkb:P97900|ensembl:ENSRNOP00000023256	intact:EBI-918511|ensembl:ENSRNOP00000020161	psi-mi:glut4_rat(display_long)|uniprotkb:Glucose transporter type 4, insulin-responsive(gene name synonym)|uniprotkb:Slc2a4(gene name)|psi-mi:Slc2a4(display_short)|uniprotkb:Glut4(gene name synonym)	psi-mi:acsl3_rat(display_long)|uniprotkb:Long-chain acyl-CoA synthetase 3(gene name synonym)|uniprotkb:Brain acyl-CoA synthetase II(gene name synonym)|uniprotkb:Acsl3(gene name)|psi-mi:Acsl3(display_short)|uniprotkb:Acs3(gene name synonym)|uniprotkb:Facl3(gene name synonym)|uniprotkb:Arachidonate--CoA ligase Acsl3(gene name synonym)|uniprotkb:Long-chain-fatty-acid--CoA ligase 3(gene name synonym)|uniprotkb:Medium-chain acyl-CoA ligase Acsl3(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Foster et al. (2006)	pubmed:16396496|mint:MINT-5218203	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-921030	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2711|refseq:NP_036883.1|refseq:XP_006246658.1|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007611"(learning or memory)|go:"GO:0007614"(short-term memory)|go:"GO:0007616"(long-term memory)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010021"(amylopectin biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031550"(positive regulation of brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044381"(glucose import in response to insulin stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046323"(glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0098694"(regulation of synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0098793"(presynapse)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002441("Glucose transporter, type 4 (GLUT4)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-189200|ensembl:ENSRNOG00000017226(gene)|ensembl:ENSRNOT00000023256(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)	rgd:70552|refseq:NP_476448.1|ensembl:ENSRNOG00000014718(gene)|ensembl:ENSRNOT00000020161(transcript)|go:"GO:0001676"(long-chain fatty acid metabolic process)|go:"GO:0004467"(long-chain fatty acid-CoA ligase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005778"(peroxisomal membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005811"(lipid droplet)|go:"GO:0005886"(plasma membrane)|go:"GO:0006633"(fatty acid biosynthetic process)|go:"GO:0007420"(brain development)|go:"GO:0007584"(response to nutrient)|go:"GO:0014070"(response to organic cyclic compound)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030182"(neuron differentiation)|go:"GO:0034379"(very-low-density lipoprotein particle assembly)|go:"GO:0035336"(long-chain fatty-acyl-CoA metabolic process)|go:"GO:0042998"(positive regulation of Golgi to plasma membrane protein transport)|go:"GO:0044539"(long-chain fatty acid import into cell)|go:"GO:0047676"(arachidonate-CoA ligase activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051047"(positive regulation of secretion)|go:"GO:2001247"(positive regulation of phosphatidylcholine biosynthetic process)|interpro:IPR000873(AMP-dependent synthetase and ligase)|interpro:IPR020845|reactome:R-RNO-434313|reactome:R-RNO-75876	-	-	-	caution:"The participant EBI-349571(P68370) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919386(Q7TP47) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920972(Q5XIP9) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-916419(P11980) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919578(Q8R491) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920554(Q5U3Z7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920647(Q5U2X8) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920585(Q7TP24) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-779677(P05426) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-915744(P02454) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|agonist:Insulin was shown to increase or decrease GLUT4 protein interactions in specific cases.|comment:"Insulin decreased GLUT4 interactions with the following proteins: Q9ER30 (Sarcosin), P09527 (Rab-7), O88960 (N-ethylmaleimide sensitive), P09456 (PKA I regulatory subunit), P27881 (Hexokinase type II), P07872 (Acyl-coenzyme A oxidase), Q6DGF1 (Isocitrate dehydrogenase), Q9EQX9 (Ubiquitin-conjugating), Q63446 (Polyubiquitin), P24268 (Cathepsin D), Q91XW0 (Heat shock protein 86), Q5FVH0 (unknown), P58405 (Striatin 3), Q62667 (Major vault protein), Q66H50 (unknown), Q09167 (splicing factor), Q9JHU5 (Arfaptin 1)."|comment:"Insulin increased GLUT4 interaction with the following proteins:Q9Z1P2 (R-actinin-1), P45592 (Cofilin), Q9QXQ0 (R-actinin-4), P26473 (ADP-ribosylation factor), P26437 (ADP-ribosylation factor),   Q7TNP1 (Basigin 2), Q6P6R2 (Dihydrolipoamide dehydrogenase),   P04797 (GAPDH), Q63081 (Protein disulfide isomerase), P29457 (47 kDa heat shock protein), Q9R1J8 (Leprecan), O88638 (Putative eps protein),   Q64375 (Synaptonemal complex)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:NDPK - Interactions involving proteins containing InterPro domain IPR001564, Nucleoside diphosphate kinase, core.	taxid:10116(rat-l6)|taxid:10116(Rattus norvegicus)	-	2006/02/15	2021/11/30	rogid:PbFY2lfrty8yw40Jq7ShR7xfuV410116	rogid:AwVrgJG05WglwAz3Niemsau9OjU10116	intact-crc:44F3A2176D02515F|rigid:9RVm0UBcqQF4k06RGKO89Bg16Q8	false	myc tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P19357	uniprotkb:Q63083	intact:EBI-915426|uniprotkb:P97900|ensembl:ENSRNOP00000023256	intact:EBI-918503|uniprotkb:P97623|uniprotkb:Q497A4|ensembl:ENSRNOP00000028390	psi-mi:glut4_rat(display_long)|uniprotkb:Glucose transporter type 4, insulin-responsive(gene name synonym)|uniprotkb:Slc2a4(gene name)|psi-mi:Slc2a4(display_short)|uniprotkb:Glut4(gene name synonym)	psi-mi:nucb1_rat(display_long)|uniprotkb:Nucb1(gene name)|psi-mi:Nucb1(display_short)|uniprotkb:Nuc(gene name synonym)|uniprotkb:CALNUC(gene name synonym)|uniprotkb:Bone 63 kDa calcium-binding protein(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Foster et al. (2006)	pubmed:16396496|mint:MINT-5218203	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-921030	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2711|refseq:NP_036883.1|refseq:XP_006246658.1|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007611"(learning or memory)|go:"GO:0007614"(short-term memory)|go:"GO:0007616"(long-term memory)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010021"(amylopectin biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031550"(positive regulation of brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044381"(glucose import in response to insulin stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046323"(glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0098694"(regulation of synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0098793"(presynapse)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002441("Glucose transporter, type 4 (GLUT4)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-189200|ensembl:ENSRNOG00000017226(gene)|ensembl:ENSRNOT00000023256(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)	rgd:620030|refseq:NP_445915.1|refseq:XP_006229227.1|ensembl:ENSRNOG00000020889(gene)|ensembl:ENSRNOT00000028390(transcript)|go:"GO:0001965"(G-protein alpha-subunit binding)|go:"GO:0003677"(DNA binding)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005769"(early endosome)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0005793"(endoplasmic reticulum-Golgi intermediate compartment)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005798"(Golgi-associated vesicle)|go:"GO:0005801"(cis-Golgi network)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0032580"(Golgi cisterna membrane)|go:"GO:0072718"(response to cisplatin)|go:"GO:0090498"(extrinsic component of Golgi membrane)|go:"GO:0098547"(lumenal side of Golgi membrane)|go:"GO:1903533"(regulation of protein targeting)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR011992(EF-Hand type)|interpro:IPR018247|interpro:IPR040250|interpro:IPR040253|reactome:R-RNO-381426|reactome:R-RNO-8957275	-	-	-	caution:"The participant EBI-349571(P68370) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919386(Q7TP47) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920972(Q5XIP9) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-916419(P11980) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919578(Q8R491) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920554(Q5U3Z7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920647(Q5U2X8) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920585(Q7TP24) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-779677(P05426) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-915744(P02454) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|agonist:Insulin was shown to increase or decrease GLUT4 protein interactions in specific cases.|comment:"Insulin decreased GLUT4 interactions with the following proteins: Q9ER30 (Sarcosin), P09527 (Rab-7), O88960 (N-ethylmaleimide sensitive), P09456 (PKA I regulatory subunit), P27881 (Hexokinase type II), P07872 (Acyl-coenzyme A oxidase), Q6DGF1 (Isocitrate dehydrogenase), Q9EQX9 (Ubiquitin-conjugating), Q63446 (Polyubiquitin), P24268 (Cathepsin D), Q91XW0 (Heat shock protein 86), Q5FVH0 (unknown), P58405 (Striatin 3), Q62667 (Major vault protein), Q66H50 (unknown), Q09167 (splicing factor), Q9JHU5 (Arfaptin 1)."|comment:"Insulin increased GLUT4 interaction with the following proteins:Q9Z1P2 (R-actinin-1), P45592 (Cofilin), Q9QXQ0 (R-actinin-4), P26473 (ADP-ribosylation factor), P26437 (ADP-ribosylation factor),   Q7TNP1 (Basigin 2), Q6P6R2 (Dihydrolipoamide dehydrogenase),   P04797 (GAPDH), Q63081 (Protein disulfide isomerase), P29457 (47 kDa heat shock protein), Q9R1J8 (Leprecan), O88638 (Putative eps protein),   Q64375 (Synaptonemal complex)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:NDPK - Interactions involving proteins containing InterPro domain IPR001564, Nucleoside diphosphate kinase, core.	taxid:10116(rat-l6)|taxid:10116(Rattus norvegicus)	-	2006/02/15	2021/11/30	rogid:PbFY2lfrty8yw40Jq7ShR7xfuV410116	rogid:kXx1jXcwaYt1bacUueE19s6UgzQ10116	intact-crc:44F3A2176D02515F|rigid:9RVm0UBcqQF4k06RGKO89Bg16Q8	false	myc tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P19357	uniprotkb:Q63081	intact:EBI-915426|uniprotkb:P97900|ensembl:ENSRNOP00000023256	intact:EBI-918490|uniprotkb:Q641Y3	psi-mi:glut4_rat(display_long)|uniprotkb:Glucose transporter type 4, insulin-responsive(gene name synonym)|uniprotkb:Slc2a4(gene name)|psi-mi:Slc2a4(display_short)|uniprotkb:Glut4(gene name synonym)	psi-mi:pdia6_rat(display_long)|uniprotkb:Pdia6(gene name)|psi-mi:Pdia6(display_short)|uniprotkb:Cabp1(gene name synonym)|uniprotkb:Txndc7(gene name synonym)|uniprotkb:Protein disulfide isomerase P5(gene name synonym)|uniprotkb:Calcium-binding protein 1(gene name synonym)|uniprotkb:Thioredoxin domain-containing protein 7(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Foster et al. (2006)	pubmed:16396496|mint:MINT-5218203	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-921030	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2711|refseq:NP_036883.1|refseq:XP_006246658.1|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007611"(learning or memory)|go:"GO:0007614"(short-term memory)|go:"GO:0007616"(long-term memory)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010021"(amylopectin biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031550"(positive regulation of brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044381"(glucose import in response to insulin stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046323"(glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0098694"(regulation of synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0098793"(presynapse)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002441("Glucose transporter, type 4 (GLUT4)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-189200|ensembl:ENSRNOG00000017226(gene)|ensembl:ENSRNOT00000023256(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)	rgd:628688|refseq:NP_001004442.1|interpro:IPR005788(Disulphide isomerase)|interpro:IPR017937|interpro:IPR013766(Thioredoxin domain)|go:"GO:0003756"(protein disulfide isomerase activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005790"(smooth endoplasmic reticulum)|go:"GO:0005793"(endoplasmic reticulum-Golgi intermediate compartment)|go:"GO:0005886"(plasma membrane)|go:"GO:0006457"(protein folding)|go:"GO:0015035"(protein-disulfide reductase activity)|go:"GO:0030168"(platelet activation)|go:"GO:0034663"(endoplasmic reticulum chaperone complex)|go:"GO:0042470"(melanosome)|go:"GO:0070527"(platelet aggregation)|go:"GO:1903895"(negative regulation of IRE1-mediated unfolded protein response)|interpro:IPR044569|interpro:IPR036249|reactome:R-RNO-381426|reactome:R-RNO-8957275	-	-	-	caution:"The participant EBI-349571(P68370) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919386(Q7TP47) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920972(Q5XIP9) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-916419(P11980) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919578(Q8R491) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920554(Q5U3Z7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920647(Q5U2X8) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920585(Q7TP24) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-779677(P05426) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-915744(P02454) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|agonist:Insulin was shown to increase or decrease GLUT4 protein interactions in specific cases.|comment:"Insulin decreased GLUT4 interactions with the following proteins: Q9ER30 (Sarcosin), P09527 (Rab-7), O88960 (N-ethylmaleimide sensitive), P09456 (PKA I regulatory subunit), P27881 (Hexokinase type II), P07872 (Acyl-coenzyme A oxidase), Q6DGF1 (Isocitrate dehydrogenase), Q9EQX9 (Ubiquitin-conjugating), Q63446 (Polyubiquitin), P24268 (Cathepsin D), Q91XW0 (Heat shock protein 86), Q5FVH0 (unknown), P58405 (Striatin 3), Q62667 (Major vault protein), Q66H50 (unknown), Q09167 (splicing factor), Q9JHU5 (Arfaptin 1)."|comment:"Insulin increased GLUT4 interaction with the following proteins:Q9Z1P2 (R-actinin-1), P45592 (Cofilin), Q9QXQ0 (R-actinin-4), P26473 (ADP-ribosylation factor), P26437 (ADP-ribosylation factor),   Q7TNP1 (Basigin 2), Q6P6R2 (Dihydrolipoamide dehydrogenase),   P04797 (GAPDH), Q63081 (Protein disulfide isomerase), P29457 (47 kDa heat shock protein), Q9R1J8 (Leprecan), O88638 (Putative eps protein),   Q64375 (Synaptonemal complex)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:NDPK - Interactions involving proteins containing InterPro domain IPR001564, Nucleoside diphosphate kinase, core.	taxid:10116(rat-l6)|taxid:10116(Rattus norvegicus)	-	2006/02/15	2021/11/30	rogid:PbFY2lfrty8yw40Jq7ShR7xfuV410116	rogid:WfJSspkQiHrTeuW1AwRqa7Z4ccs10116	intact-crc:44F3A2176D02515F|rigid:9RVm0UBcqQF4k06RGKO89Bg16Q8	false	myc tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P19357	uniprotkb:P02454	intact:EBI-915426|uniprotkb:P97900|ensembl:ENSRNOP00000023256	intact:EBI-915744|uniprotkb:P02455|uniprotkb:Q63079|ensembl:ENSRNOP00000005311|uniprotkb:A3KNA1	psi-mi:glut4_rat(display_long)|uniprotkb:Glucose transporter type 4, insulin-responsive(gene name synonym)|uniprotkb:Slc2a4(gene name)|psi-mi:Slc2a4(display_short)|uniprotkb:Glut4(gene name synonym)	psi-mi:co1a1_rat(display_long)|uniprotkb:Alpha-1 type I collagen(gene name synonym)|uniprotkb:Col1a1(gene name)|psi-mi:Col1a1(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Foster et al. (2006)	pubmed:16396496|mint:MINT-5218203	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-921030	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2711|refseq:NP_036883.1|refseq:XP_006246658.1|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007611"(learning or memory)|go:"GO:0007614"(short-term memory)|go:"GO:0007616"(long-term memory)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010021"(amylopectin biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031550"(positive regulation of brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044381"(glucose import in response to insulin stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046323"(glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0098694"(regulation of synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0098793"(presynapse)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002441("Glucose transporter, type 4 (GLUT4)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-189200|ensembl:ENSRNOG00000017226(gene)|ensembl:ENSRNOT00000023256(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)	rgd:61817|refseq:NP_445756.1|ensembl:ENSRNOG00000003897(gene)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0009612"(response to mechanical stimulus)|go:"GO:0010718"(positive regulation of epithelial to mesenchymal transition)|go:"GO:0010812"(negative regulation of cell-substrate adhesion)|go:"GO:0015031"(protein transport)|ensembl:ENSRNOT00000005311(transcript)|go:"GO:0030141"(secretory granule)|go:"GO:0001501"(skeletal system development)|go:"GO:0030198"(extracellular matrix organization)|go:"GO:0001503"(ossification)|go:"GO:0001568"(blood vessel development)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0030199"(collagen fibril organization)|go:"GO:0001957"(intramembranous ossification)|go:"GO:0001958"(endochondral ossification)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0002020"(protease binding)|go:"GO:0005201"(extracellular matrix structural constituent)|go:"GO:0031012"(extracellular matrix)|go:"GO:0031667"(response to nutrient levels)|go:"GO:0031960"(response to corticosteroid)|go:"GO:0005576"(extracellular region)|go:"GO:0005581"(collagen trimer)|go:"GO:0005584"(collagen type I trimer)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0007584"(response to nutrient)|go:"GO:0007601"(visual perception)|go:"GO:1902618"(cellular response to fluoride)|interpro:IPR000885(Fibrillar collagen, C-terminal)|interpro:IPR001007(von Willebrand factor, type C)|interpro:IPR008160(Collagen triple helix repeat)|rcsb pdb:3HQV|rcsb pdb:3HR2|reactome:R-RNO-114604|reactome:R-RNO-1442490|reactome:R-RNO-1474244|reactome:R-RNO-1650814|reactome:R-RNO-198933|reactome:R-RNO-2022090|reactome:R-RNO-202733|reactome:R-RNO-216083|reactome:R-RNO-2243919|reactome:R-RNO-3000171|reactome:R-RNO-3000178|reactome:R-RNO-430116|go:"GO:0032355"(response to estradiol)|go:"GO:0032964"(collagen biosynthetic process)|go:"GO:0034504"(protein localization to nucleus)|go:"GO:0034505"(tooth mineralization)|go:"GO:0038063"(collagen-activated tyrosine kinase receptor signaling pathway)|go:"GO:0042060"(wound healing)|go:"GO:0042493"|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0042802"(identical protein binding)|go:"GO:0043434"(response to peptide hormone)|go:"GO:0043588"(skin development)|go:"GO:0043589"(skin morphogenesis)|go:"GO:0044344"(cellular response to fibroblast growth factor stimulus)|go:"GO:0044691"(tooth eruption)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046872"(metal ion binding)|go:"GO:0048407"(platelet-derived growth factor binding)|go:"GO:0048545"(response to steroid hormone)|go:"GO:0048705"(skeletal system morphogenesis)|go:"GO:0048706"(embryonic skeletal system development)|go:"GO:0051591"(response to cAMP)|go:"GO:0055093"(response to hyperoxia)|go:"GO:0060325"(face morphogenesis)|go:"GO:0060346"(bone trabecula formation)|go:"GO:0060351"(cartilage development involved in endochondral bone morphogenesis)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071300"(cellular response to retinoic acid)|go:"GO:0071306"(cellular response to vitamin E)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:1902617"(response to fluoride)|dip:DIP-36887N|reactome:R-RNO-75892|reactome:R-RNO-76009|reactome:R-RNO-8874081|reactome:R-RNO-8948216	-	-	-	caution:"The participant EBI-349571(P68370) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919386(Q7TP47) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920972(Q5XIP9) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-916419(P11980) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919578(Q8R491) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920554(Q5U3Z7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920647(Q5U2X8) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920585(Q7TP24) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-779677(P05426) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-915744(P02454) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|agonist:Insulin was shown to increase or decrease GLUT4 protein interactions in specific cases.|comment:"Insulin decreased GLUT4 interactions with the following proteins: Q9ER30 (Sarcosin), P09527 (Rab-7), O88960 (N-ethylmaleimide sensitive), P09456 (PKA I regulatory subunit), P27881 (Hexokinase type II), P07872 (Acyl-coenzyme A oxidase), Q6DGF1 (Isocitrate dehydrogenase), Q9EQX9 (Ubiquitin-conjugating), Q63446 (Polyubiquitin), P24268 (Cathepsin D), Q91XW0 (Heat shock protein 86), Q5FVH0 (unknown), P58405 (Striatin 3), Q62667 (Major vault protein), Q66H50 (unknown), Q09167 (splicing factor), Q9JHU5 (Arfaptin 1)."|comment:"Insulin increased GLUT4 interaction with the following proteins:Q9Z1P2 (R-actinin-1), P45592 (Cofilin), Q9QXQ0 (R-actinin-4), P26473 (ADP-ribosylation factor), P26437 (ADP-ribosylation factor),   Q7TNP1 (Basigin 2), Q6P6R2 (Dihydrolipoamide dehydrogenase),   P04797 (GAPDH), Q63081 (Protein disulfide isomerase), P29457 (47 kDa heat shock protein), Q9R1J8 (Leprecan), O88638 (Putative eps protein),   Q64375 (Synaptonemal complex)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:NDPK - Interactions involving proteins containing InterPro domain IPR001564, Nucleoside diphosphate kinase, core.	taxid:10116(rat-l6)|taxid:10116(Rattus norvegicus)	-	2006/02/15	2021/11/30	rogid:PbFY2lfrty8yw40Jq7ShR7xfuV410116	rogid:eng4MkFnf/zWoFkxosROYXl6VuU10116	intact-crc:44F3A2176D02515F|rigid:9RVm0UBcqQF4k06RGKO89Bg16Q8	false	myc tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P19357	uniprotkb:Q63016	intact:EBI-915426|uniprotkb:P97900|ensembl:ENSRNOP00000023256	intact:EBI-918480|uniprotkb:Q9QWL4|ensembl:ENSRNOP00000025784	psi-mi:glut4_rat(display_long)|uniprotkb:Glucose transporter type 4, insulin-responsive(gene name synonym)|uniprotkb:Slc2a4(gene name)|psi-mi:Slc2a4(display_short)|uniprotkb:Glut4(gene name synonym)	psi-mi:lat1_rat(display_long)|uniprotkb:L-type amino acid transporter 1(gene name synonym)|uniprotkb:Slc7a5(gene name)|psi-mi:Slc7a5(display_short)|uniprotkb:Mpe16(gene name synonym)|uniprotkb:Ta1(gene name synonym)|uniprotkb:Solute carrier family 7 member 5(gene name synonym)|uniprotkb:4F2 light chain(gene name synonym)|uniprotkb:Integral membrane protein E16(gene name synonym)|uniprotkb:Lat1(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Foster et al. (2006)	pubmed:16396496|mint:MINT-5218203	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-921030	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2711|refseq:NP_036883.1|refseq:XP_006246658.1|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007611"(learning or memory)|go:"GO:0007614"(short-term memory)|go:"GO:0007616"(long-term memory)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010021"(amylopectin biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031550"(positive regulation of brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044381"(glucose import in response to insulin stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046323"(glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0098694"(regulation of synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0098793"(presynapse)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002441("Glucose transporter, type 4 (GLUT4)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-189200|ensembl:ENSRNOG00000017226(gene)|ensembl:ENSRNOT00000023256(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)	refseq:NP_059049.1|rgd:620639|ensembl:ENSRNOG00000018824(gene)|ensembl:ENSRNOT00000025784(transcript)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0009925"(basal plasma membrane)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0015171"(amino acid transmembrane transporter activity)|go:"GO:0015173"(aromatic amino acid transmembrane transporter activity)|go:"GO:0015175"(neutral amino acid transmembrane transporter activity)|go:"GO:0015179"(L-amino acid transmembrane transporter activity)|go:"GO:0015190"(L-leucine transmembrane transporter activity)|go:"GO:0015196"(L-tryptophan transmembrane transporter activity)|go:"GO:0015349"(thyroid hormone transmembrane transporter activity)|go:"GO:0015804"(neutral amino acid transport)|go:"GO:0015807"(L-amino acid transport)|go:"GO:0015823"(phenylalanine transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0031528"(microvillus membrane)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032740"(positive regulation of interleukin-17 production)|go:"GO:0032753"(positive regulation of interleukin-4 production)|go:"GO:0042605"(peptide antigen binding)|go:"GO:0042908"(xenobiotic transport)|go:"GO:0070327"(thyroid hormone transport)|go:"GO:0089718"(amino acid import across plasma membrane)|go:"GO:0098591"(external side of apical plasma membrane)|go:"GO:0098713"(leucine import across plasma membrane)|go:"GO:1903801"(L-leucine import across plasma membrane)|go:"GO:1904556"(L-tryptophan transmembrane transport)|go:"GO:1990184"(amino acid transport complex)|interpro:IPR002293(Amino acid/polyamine transporter I)|interpro:IPR004760(L-type amino acid transporter)|reactome:R-RNO-210991|reactome:R-RNO-352230|reactome:R-RNO-71240	-	-	-	caution:"The participant EBI-349571(P68370) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919386(Q7TP47) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920972(Q5XIP9) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-916419(P11980) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919578(Q8R491) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920554(Q5U3Z7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920647(Q5U2X8) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920585(Q7TP24) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-779677(P05426) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-915744(P02454) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|agonist:Insulin was shown to increase or decrease GLUT4 protein interactions in specific cases.|comment:"Insulin decreased GLUT4 interactions with the following proteins: Q9ER30 (Sarcosin), P09527 (Rab-7), O88960 (N-ethylmaleimide sensitive), P09456 (PKA I regulatory subunit), P27881 (Hexokinase type II), P07872 (Acyl-coenzyme A oxidase), Q6DGF1 (Isocitrate dehydrogenase), Q9EQX9 (Ubiquitin-conjugating), Q63446 (Polyubiquitin), P24268 (Cathepsin D), Q91XW0 (Heat shock protein 86), Q5FVH0 (unknown), P58405 (Striatin 3), Q62667 (Major vault protein), Q66H50 (unknown), Q09167 (splicing factor), Q9JHU5 (Arfaptin 1)."|comment:"Insulin increased GLUT4 interaction with the following proteins:Q9Z1P2 (R-actinin-1), P45592 (Cofilin), Q9QXQ0 (R-actinin-4), P26473 (ADP-ribosylation factor), P26437 (ADP-ribosylation factor),   Q7TNP1 (Basigin 2), Q6P6R2 (Dihydrolipoamide dehydrogenase),   P04797 (GAPDH), Q63081 (Protein disulfide isomerase), P29457 (47 kDa heat shock protein), Q9R1J8 (Leprecan), O88638 (Putative eps protein),   Q64375 (Synaptonemal complex)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:NDPK - Interactions involving proteins containing InterPro domain IPR001564, Nucleoside diphosphate kinase, core.	taxid:10116(rat-l6)|taxid:10116(Rattus norvegicus)	-	2006/02/15	2021/11/30	rogid:PbFY2lfrty8yw40Jq7ShR7xfuV410116	rogid:lZKC9gbvHdSue41rDI3DqkfCy4810116	intact-crc:44F3A2176D02515F|rigid:9RVm0UBcqQF4k06RGKO89Bg16Q8	false	myc tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P19357	uniprotkb:Q63002	intact:EBI-915426|uniprotkb:P97900|ensembl:ENSRNOP00000023256	intact:EBI-918467|uniprotkb:Q63757	psi-mi:glut4_rat(display_long)|uniprotkb:Glucose transporter type 4, insulin-responsive(gene name synonym)|uniprotkb:Slc2a4(gene name)|psi-mi:Slc2a4(display_short)|uniprotkb:Glut4(gene name synonym)	psi-mi:q63002_rat(display_long)|uniprotkb:M6P/IGF2r(gene name)|psi-mi:M6P/IGF2r(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Foster et al. (2006)	pubmed:16396496|mint:MINT-5218203	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-921030	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2711|refseq:NP_036883.1|refseq:XP_006246658.1|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007611"(learning or memory)|go:"GO:0007614"(short-term memory)|go:"GO:0007616"(long-term memory)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010021"(amylopectin biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031550"(positive regulation of brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044381"(glucose import in response to insulin stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046323"(glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0098694"(regulation of synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0098793"(presynapse)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002441("Glucose transporter, type 4 (GLUT4)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-189200|ensembl:ENSRNOG00000017226(gene)|ensembl:ENSRNOT00000023256(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)	interpro:IPR000479(Cation-independent mannose-6-phosphate receptor)|interpro:IPR000562(Type II fibronectin, collagen-binding)|interpro:IPR013806(Kringle-like fold)|interpro:IPR009011(Mannose-6-phosphate receptor, binding)|interpro:IPR044865|interpro:IPR036943|go:"GO:0005537"(mannose binding)|go:"GO:0007041"(lysosomal transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0038023"(signaling receptor activity)	-	-	-	caution:"The participant EBI-349571(P68370) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919386(Q7TP47) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920972(Q5XIP9) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-916419(P11980) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919578(Q8R491) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920554(Q5U3Z7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920647(Q5U2X8) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920585(Q7TP24) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-779677(P05426) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-915744(P02454) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|agonist:Insulin was shown to increase or decrease GLUT4 protein interactions in specific cases.|comment:"Insulin decreased GLUT4 interactions with the following proteins: Q9ER30 (Sarcosin), P09527 (Rab-7), O88960 (N-ethylmaleimide sensitive), P09456 (PKA I regulatory subunit), P27881 (Hexokinase type II), P07872 (Acyl-coenzyme A oxidase), Q6DGF1 (Isocitrate dehydrogenase), Q9EQX9 (Ubiquitin-conjugating), Q63446 (Polyubiquitin), P24268 (Cathepsin D), Q91XW0 (Heat shock protein 86), Q5FVH0 (unknown), P58405 (Striatin 3), Q62667 (Major vault protein), Q66H50 (unknown), Q09167 (splicing factor), Q9JHU5 (Arfaptin 1)."|comment:"Insulin increased GLUT4 interaction with the following proteins:Q9Z1P2 (R-actinin-1), P45592 (Cofilin), Q9QXQ0 (R-actinin-4), P26473 (ADP-ribosylation factor), P26437 (ADP-ribosylation factor),   Q7TNP1 (Basigin 2), Q6P6R2 (Dihydrolipoamide dehydrogenase),   P04797 (GAPDH), Q63081 (Protein disulfide isomerase), P29457 (47 kDa heat shock protein), Q9R1J8 (Leprecan), O88638 (Putative eps protein),   Q64375 (Synaptonemal complex)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:NDPK - Interactions involving proteins containing InterPro domain IPR001564, Nucleoside diphosphate kinase, core.	taxid:10116(rat-l6)|taxid:10116(Rattus norvegicus)	-	2006/02/15	2021/11/30	rogid:PbFY2lfrty8yw40Jq7ShR7xfuV410116	rogid:6xXWtXt4wjjUSfR9OmcdVNilbc010116	intact-crc:44F3A2176D02515F|rigid:9RVm0UBcqQF4k06RGKO89Bg16Q8	false	myc tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P19357	uniprotkb:Q62952	intact:EBI-915426|uniprotkb:P97900|ensembl:ENSRNOP00000023256	intact:EBI-918447|uniprotkb:Q8K4H3|uniprotkb:Q91XM8|ensembl:ENSRNOP00000070679	psi-mi:glut4_rat(display_long)|uniprotkb:Glucose transporter type 4, insulin-responsive(gene name synonym)|uniprotkb:Slc2a4(gene name)|psi-mi:Slc2a4(display_short)|uniprotkb:Glut4(gene name synonym)	psi-mi:dpyl3_rat(display_long)|uniprotkb:Collapsin response mediator protein 4(gene name synonym)|uniprotkb:TOAD-64/Ulip/CRMP(gene name synonym)|uniprotkb:TUC-4b(gene name synonym)|uniprotkb:Dpysl3(gene name)|psi-mi:Dpysl3(display_short)|uniprotkb:Crmp4(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Foster et al. (2006)	pubmed:16396496|mint:MINT-5218203	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-921030	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2711|refseq:NP_036883.1|refseq:XP_006246658.1|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007611"(learning or memory)|go:"GO:0007614"(short-term memory)|go:"GO:0007616"(long-term memory)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010021"(amylopectin biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031550"(positive regulation of brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044381"(glucose import in response to insulin stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046323"(glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0098694"(regulation of synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0098793"(presynapse)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002441("Glucose transporter, type 4 (GLUT4)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-189200|ensembl:ENSRNOG00000017226(gene)|ensembl:ENSRNOT00000023256(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)	rgd:2410|refseq:NP_037066.1|refseq:XP_006254732.1|ensembl:ENSRNOG00000018992(gene)|ensembl:ENSRNOT00000087876(transcript)|go:"GO:0005615"(extracellular space)|go:"GO:0005829"(cytosol)|go:"GO:0007399"(nervous system development)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0016810"("hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds")|go:"GO:0017124"(SH3 domain binding)|go:"GO:0030027"(lamellipodium)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0030426"(growth cone)|go:"GO:0031005"(filamin binding)|go:"GO:0031941"(filamentous actin)|go:"GO:0035374"(chondroitin sulfate binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0044297"(cell body)|go:"GO:0045202"(synapse)|go:"GO:0048666"(neuron development)|go:"GO:0048678"(response to axon injury)|go:"GO:0051017"(actin filament bundle assembly)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0051764"(actin crosslink formation)|go:"GO:0071345"(cellular response to cytokine stimulus)|interpro:IPR006680(Amidohydrolase 1)|interpro:IPR011059(Metal-dependent hydrolase, composite)|interpro:IPR011778(D-hydantoinase)|interpro:IPR030628|interpro:IPR032466|reactome:R-RNO-399956	-	-	-	caution:"The participant EBI-349571(P68370) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919386(Q7TP47) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920972(Q5XIP9) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-916419(P11980) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919578(Q8R491) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920554(Q5U3Z7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920647(Q5U2X8) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920585(Q7TP24) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-779677(P05426) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-915744(P02454) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|agonist:Insulin was shown to increase or decrease GLUT4 protein interactions in specific cases.|comment:"Insulin decreased GLUT4 interactions with the following proteins: Q9ER30 (Sarcosin), P09527 (Rab-7), O88960 (N-ethylmaleimide sensitive), P09456 (PKA I regulatory subunit), P27881 (Hexokinase type II), P07872 (Acyl-coenzyme A oxidase), Q6DGF1 (Isocitrate dehydrogenase), Q9EQX9 (Ubiquitin-conjugating), Q63446 (Polyubiquitin), P24268 (Cathepsin D), Q91XW0 (Heat shock protein 86), Q5FVH0 (unknown), P58405 (Striatin 3), Q62667 (Major vault protein), Q66H50 (unknown), Q09167 (splicing factor), Q9JHU5 (Arfaptin 1)."|comment:"Insulin increased GLUT4 interaction with the following proteins:Q9Z1P2 (R-actinin-1), P45592 (Cofilin), Q9QXQ0 (R-actinin-4), P26473 (ADP-ribosylation factor), P26437 (ADP-ribosylation factor),   Q7TNP1 (Basigin 2), Q6P6R2 (Dihydrolipoamide dehydrogenase),   P04797 (GAPDH), Q63081 (Protein disulfide isomerase), P29457 (47 kDa heat shock protein), Q9R1J8 (Leprecan), O88638 (Putative eps protein),   Q64375 (Synaptonemal complex)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:NDPK - Interactions involving proteins containing InterPro domain IPR001564, Nucleoside diphosphate kinase, core.	taxid:10116(rat-l6)|taxid:10116(Rattus norvegicus)	-	2006/02/15	2021/11/30	rogid:PbFY2lfrty8yw40Jq7ShR7xfuV410116	rogid:VacdQhRJUbTrDwR2YT55BdvA2Z810116	intact-crc:44F3A2176D02515F|rigid:9RVm0UBcqQF4k06RGKO89Bg16Q8	false	myc tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P19357	uniprotkb:Q62920	intact:EBI-915426|uniprotkb:P97900|ensembl:ENSRNOP00000023256	intact:EBI-918433|ensembl:ENSRNOP00000022387	psi-mi:glut4_rat(display_long)|uniprotkb:Glucose transporter type 4, insulin-responsive(gene name synonym)|uniprotkb:Slc2a4(gene name)|psi-mi:Slc2a4(display_short)|uniprotkb:Glut4(gene name synonym)	psi-mi:pdli5_rat(display_long)|uniprotkb:Enigma homolog(gene name synonym)|uniprotkb:Enigma-like PDZ and LIM domains protein(gene name synonym)|uniprotkb:Pdlim5(gene name)|psi-mi:Pdlim5(display_short)|uniprotkb:Enh(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Foster et al. (2006)	pubmed:16396496|mint:MINT-5218203	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-921030	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2711|refseq:NP_036883.1|refseq:XP_006246658.1|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007611"(learning or memory)|go:"GO:0007614"(short-term memory)|go:"GO:0007616"(long-term memory)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010021"(amylopectin biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031550"(positive regulation of brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044381"(glucose import in response to insulin stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046323"(glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0098694"(regulation of synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0098793"(presynapse)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002441("Glucose transporter, type 4 (GLUT4)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-189200|ensembl:ENSRNOG00000017226(gene)|ensembl:ENSRNOT00000023256(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)	rgd:621076|refseq:NP_445778.1|refseq:XP_006233481.1|ensembl:ENSRNOG00000016419(gene)|ensembl:ENSRNOT00000022387(transcript)|go:"GO:0001725"(stress fiber)|go:"GO:0003779"(actin binding)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005829"(cytosol)|go:"GO:0005912"(adherens junction)|go:"GO:0007507"(heart development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0030018"(Z disc)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0031941"(filamentous actin)|go:"GO:0042805"(actinin binding)|go:"GO:0042995"(cell projection)|go:"GO:0046872"(metal ion binding)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0051371"(muscle alpha-actinin binding)|go:"GO:0051963"(regulation of synapse assembly)|go:"GO:0061001"(regulation of dendritic spine morphogenesis)|go:"GO:0061049"(cell growth involved in cardiac muscle cell development)|go:"GO:0061061"(muscle structure development)|go:"GO:0098793"(presynapse)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001781(Zinc finger, LIM-type)|interpro:IPR031847|interpro:IPR036034	-	-	-	caution:"The participant EBI-349571(P68370) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919386(Q7TP47) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920972(Q5XIP9) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-916419(P11980) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919578(Q8R491) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920554(Q5U3Z7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920647(Q5U2X8) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920585(Q7TP24) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-779677(P05426) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-915744(P02454) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|agonist:Insulin was shown to increase or decrease GLUT4 protein interactions in specific cases.|comment:"Insulin decreased GLUT4 interactions with the following proteins: Q9ER30 (Sarcosin), P09527 (Rab-7), O88960 (N-ethylmaleimide sensitive), P09456 (PKA I regulatory subunit), P27881 (Hexokinase type II), P07872 (Acyl-coenzyme A oxidase), Q6DGF1 (Isocitrate dehydrogenase), Q9EQX9 (Ubiquitin-conjugating), Q63446 (Polyubiquitin), P24268 (Cathepsin D), Q91XW0 (Heat shock protein 86), Q5FVH0 (unknown), P58405 (Striatin 3), Q62667 (Major vault protein), Q66H50 (unknown), Q09167 (splicing factor), Q9JHU5 (Arfaptin 1)."|comment:"Insulin increased GLUT4 interaction with the following proteins:Q9Z1P2 (R-actinin-1), P45592 (Cofilin), Q9QXQ0 (R-actinin-4), P26473 (ADP-ribosylation factor), P26437 (ADP-ribosylation factor),   Q7TNP1 (Basigin 2), Q6P6R2 (Dihydrolipoamide dehydrogenase),   P04797 (GAPDH), Q63081 (Protein disulfide isomerase), P29457 (47 kDa heat shock protein), Q9R1J8 (Leprecan), O88638 (Putative eps protein),   Q64375 (Synaptonemal complex)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:NDPK - Interactions involving proteins containing InterPro domain IPR001564, Nucleoside diphosphate kinase, core.	taxid:10116(rat-l6)|taxid:10116(Rattus norvegicus)	-	2006/02/15	2021/11/30	rogid:PbFY2lfrty8yw40Jq7ShR7xfuV410116	rogid:qWTPsYx+SRcdV1D+fZfCghsniiQ10116	intact-crc:44F3A2176D02515F|rigid:9RVm0UBcqQF4k06RGKO89Bg16Q8	false	myc tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P19357	uniprotkb:Q62908	intact:EBI-915426|uniprotkb:P97900|ensembl:ENSRNOP00000023256	intact:EBI-918425	psi-mi:glut4_rat(display_long)|uniprotkb:Glucose transporter type 4, insulin-responsive(gene name synonym)|uniprotkb:Slc2a4(gene name)|psi-mi:Slc2a4(display_short)|uniprotkb:Glut4(gene name synonym)	psi-mi:csrp2_rat(display_long)|uniprotkb:Smooth muscle cell LIM protein(gene name synonym)|uniprotkb:Csrp2(gene name)|psi-mi:Csrp2(display_short)|uniprotkb:Smlim(gene name synonym)|uniprotkb:Cysteine-rich protein 2(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Foster et al. (2006)	pubmed:16396496|mint:MINT-5218203	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-921030	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2711|refseq:NP_036883.1|refseq:XP_006246658.1|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007611"(learning or memory)|go:"GO:0007614"(short-term memory)|go:"GO:0007616"(long-term memory)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010021"(amylopectin biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031550"(positive regulation of brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044381"(glucose import in response to insulin stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046323"(glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0098694"(regulation of synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0098793"(presynapse)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002441("Glucose transporter, type 4 (GLUT4)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-189200|ensembl:ENSRNOG00000017226(gene)|ensembl:ENSRNOT00000023256(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)	rgd:61950|refseq:NP_803174.2|dip:DIP-36882N|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0008307"(structural constituent of muscle)|go:"GO:0030018"(Z disc)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0042805"(actinin binding)|go:"GO:0045214"(sarcomere organization)|go:"GO:0045445"(myoblast differentiation)|go:"GO:0046872"(metal ion binding)|go:"GO:0060537"(muscle tissue development)|interpro:IPR001781(Zinc finger, LIM-type)	-	-	-	caution:"The participant EBI-349571(P68370) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919386(Q7TP47) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920972(Q5XIP9) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-916419(P11980) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919578(Q8R491) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920554(Q5U3Z7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920647(Q5U2X8) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920585(Q7TP24) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-779677(P05426) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-915744(P02454) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|agonist:Insulin was shown to increase or decrease GLUT4 protein interactions in specific cases.|comment:"Insulin decreased GLUT4 interactions with the following proteins: Q9ER30 (Sarcosin), P09527 (Rab-7), O88960 (N-ethylmaleimide sensitive), P09456 (PKA I regulatory subunit), P27881 (Hexokinase type II), P07872 (Acyl-coenzyme A oxidase), Q6DGF1 (Isocitrate dehydrogenase), Q9EQX9 (Ubiquitin-conjugating), Q63446 (Polyubiquitin), P24268 (Cathepsin D), Q91XW0 (Heat shock protein 86), Q5FVH0 (unknown), P58405 (Striatin 3), Q62667 (Major vault protein), Q66H50 (unknown), Q09167 (splicing factor), Q9JHU5 (Arfaptin 1)."|comment:"Insulin increased GLUT4 interaction with the following proteins:Q9Z1P2 (R-actinin-1), P45592 (Cofilin), Q9QXQ0 (R-actinin-4), P26473 (ADP-ribosylation factor), P26437 (ADP-ribosylation factor),   Q7TNP1 (Basigin 2), Q6P6R2 (Dihydrolipoamide dehydrogenase),   P04797 (GAPDH), Q63081 (Protein disulfide isomerase), P29457 (47 kDa heat shock protein), Q9R1J8 (Leprecan), O88638 (Putative eps protein),   Q64375 (Synaptonemal complex)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:NDPK - Interactions involving proteins containing InterPro domain IPR001564, Nucleoside diphosphate kinase, core.	taxid:10116(rat-l6)|taxid:10116(Rattus norvegicus)	-	2006/02/15	2021/11/30	rogid:PbFY2lfrty8yw40Jq7ShR7xfuV410116	rogid:5CSA5iYkT4aYC/EyBFRtQpvRUew10116	intact-crc:44F3A2176D02515F|rigid:9RVm0UBcqQF4k06RGKO89Bg16Q8	false	myc tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P19357	uniprotkb:Q62902	intact:EBI-915426|uniprotkb:P97900|ensembl:ENSRNOP00000023256	intact:EBI-918417	psi-mi:glut4_rat(display_long)|uniprotkb:Glucose transporter type 4, insulin-responsive(gene name synonym)|uniprotkb:Slc2a4(gene name)|psi-mi:Slc2a4(display_short)|uniprotkb:Glut4(gene name synonym)	psi-mi:lman1_rat(display_long)|uniprotkb:ER-Golgi intermediate compartment 53 kDa protein(gene name synonym)|uniprotkb:Lectin mannose-binding 1(gene name synonym)|uniprotkb:p58(gene name synonym)|uniprotkb:Lman1(gene name)|psi-mi:Lman1(display_short)|uniprotkb:Ergic53(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Foster et al. (2006)	pubmed:16396496|mint:MINT-5218203	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-921030	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2711|refseq:NP_036883.1|refseq:XP_006246658.1|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007611"(learning or memory)|go:"GO:0007614"(short-term memory)|go:"GO:0007616"(long-term memory)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010021"(amylopectin biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031550"(positive regulation of brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044381"(glucose import in response to insulin stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046323"(glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0098694"(regulation of synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0098793"(presynapse)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002441("Glucose transporter, type 4 (GLUT4)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-189200|ensembl:ENSRNOG00000017226(gene)|ensembl:ENSRNOT00000023256(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)	rgd:71020|refseq:NP_446338.1|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR005052(Legume-like lectin)|interpro:IPR033085|mint:Q62902|go:"GO:0000139"(Golgi membrane)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005537"(mannose binding)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005793"(endoplasmic reticulum-Golgi intermediate compartment)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006888"(endoplasmic reticulum to Golgi vesicle-mediated transport)|go:"GO:0007029"(endoplasmic reticulum organization)|go:"GO:0007030"(Golgi organization)|go:"GO:0010638"(positive regulation of organelle organization)|go:"GO:0015031"(protein transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030017"(sarcomere)|go:"GO:0030134"(COPII-coated ER to Golgi transport vesicle)|go:"GO:0033116"(endoplasmic reticulum-Golgi intermediate compartment membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|rcsb pdb:1GV9|rcsb pdb:1R1Z|reactome:R-RNO-204005|reactome:R-RNO-5694530|reactome:R-RNO-8980692|reactome:R-RNO-9013106|reactome:R-RNO-9013404|reactome:R-RNO-9013405|reactome:R-RNO-9013408|reactome:R-RNO-9013423	-	-	-	caution:"The participant EBI-349571(P68370) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919386(Q7TP47) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920972(Q5XIP9) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-916419(P11980) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919578(Q8R491) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920554(Q5U3Z7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920647(Q5U2X8) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920585(Q7TP24) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-779677(P05426) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-915744(P02454) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|agonist:Insulin was shown to increase or decrease GLUT4 protein interactions in specific cases.|comment:"Insulin decreased GLUT4 interactions with the following proteins: Q9ER30 (Sarcosin), P09527 (Rab-7), O88960 (N-ethylmaleimide sensitive), P09456 (PKA I regulatory subunit), P27881 (Hexokinase type II), P07872 (Acyl-coenzyme A oxidase), Q6DGF1 (Isocitrate dehydrogenase), Q9EQX9 (Ubiquitin-conjugating), Q63446 (Polyubiquitin), P24268 (Cathepsin D), Q91XW0 (Heat shock protein 86), Q5FVH0 (unknown), P58405 (Striatin 3), Q62667 (Major vault protein), Q66H50 (unknown), Q09167 (splicing factor), Q9JHU5 (Arfaptin 1)."|comment:"Insulin increased GLUT4 interaction with the following proteins:Q9Z1P2 (R-actinin-1), P45592 (Cofilin), Q9QXQ0 (R-actinin-4), P26473 (ADP-ribosylation factor), P26437 (ADP-ribosylation factor),   Q7TNP1 (Basigin 2), Q6P6R2 (Dihydrolipoamide dehydrogenase),   P04797 (GAPDH), Q63081 (Protein disulfide isomerase), P29457 (47 kDa heat shock protein), Q9R1J8 (Leprecan), O88638 (Putative eps protein),   Q64375 (Synaptonemal complex)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:NDPK - Interactions involving proteins containing InterPro domain IPR001564, Nucleoside diphosphate kinase, core.	taxid:10116(rat-l6)|taxid:10116(Rattus norvegicus)	-	2006/02/15	2021/11/30	rogid:PbFY2lfrty8yw40Jq7ShR7xfuV410116	rogid:82fmuWuYw9xjFb53z9p2mqO+GiQ10116	intact-crc:44F3A2176D02515F|rigid:9RVm0UBcqQF4k06RGKO89Bg16Q8	false	myc tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P19357	uniprotkb:Q62871	intact:EBI-915426|uniprotkb:P97900|ensembl:ENSRNOP00000023256	intact:EBI-918392|uniprotkb:Q62872|uniprotkb:Q62873	psi-mi:glut4_rat(display_long)|uniprotkb:Glucose transporter type 4, insulin-responsive(gene name synonym)|uniprotkb:Slc2a4(gene name)|psi-mi:Slc2a4(display_short)|uniprotkb:Glut4(gene name synonym)	psi-mi:dc1i2_rat(display_long)|uniprotkb:Dync1i2(gene name)|psi-mi:Dync1i2(display_short)|uniprotkb:Dnci2(gene name synonym)|uniprotkb:Dncic2(gene name synonym)|uniprotkb:Cytoplasmic dynein intermediate chain 2(gene name synonym)|uniprotkb:Dynein intermediate chain 2, cytosolic(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Foster et al. (2006)	pubmed:16396496|mint:MINT-5218203	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-921030	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2711|refseq:NP_036883.1|refseq:XP_006246658.1|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007611"(learning or memory)|go:"GO:0007614"(short-term memory)|go:"GO:0007616"(long-term memory)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010021"(amylopectin biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031550"(positive regulation of brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044381"(glucose import in response to insulin stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046323"(glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0098694"(regulation of synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0098793"(presynapse)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002441("Glucose transporter, type 4 (GLUT4)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-189200|ensembl:ENSRNOG00000017226(gene)|ensembl:ENSRNOT00000023256(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)	rgd:620174|dip:DIP-36880N|reactome:R-RNO-141444|reactome:R-RNO-2132295|reactome:R-RNO-2467813|reactome:R-RNO-2500257|reactome:R-RNO-2565942|reactome:R-RNO-3371497|reactome:R-RNO-380259|reactome:R-RNO-380270|reactome:R-RNO-380284|reactome:R-RNO-380320|reactome:R-RNO-5620912|reactome:R-RNO-5663220|reactome:R-RNO-6807878|reactome:R-RNO-6811436|reactome:R-RNO-68877|reactome:R-RNO-8854518|reactome:R-RNO-9646399|reactome:R-RNO-9648025|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005868"(cytoplasmic dynein complex)|go:"GO:0005874"(microtubule)|go:"GO:0007018"(microtubule-based movement)|go:"GO:0007420"(brain development)|go:"GO:0010970"(transport along microtubule)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0031982"(vesicle)|go:"GO:0036157"(outer dynein arm)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045503"(dynein light chain binding)|go:"GO:0045504"(dynein heavy chain binding)|go:"GO:1990090"(cellular response to nerve growth factor stimulus)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR025956|interpro:IPR036322|rcsb pdb:2PG1	-	-	-	caution:"The participant EBI-349571(P68370) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919386(Q7TP47) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920972(Q5XIP9) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-916419(P11980) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919578(Q8R491) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920554(Q5U3Z7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920647(Q5U2X8) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920585(Q7TP24) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-779677(P05426) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-915744(P02454) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|agonist:Insulin was shown to increase or decrease GLUT4 protein interactions in specific cases.|comment:"Insulin decreased GLUT4 interactions with the following proteins: Q9ER30 (Sarcosin), P09527 (Rab-7), O88960 (N-ethylmaleimide sensitive), P09456 (PKA I regulatory subunit), P27881 (Hexokinase type II), P07872 (Acyl-coenzyme A oxidase), Q6DGF1 (Isocitrate dehydrogenase), Q9EQX9 (Ubiquitin-conjugating), Q63446 (Polyubiquitin), P24268 (Cathepsin D), Q91XW0 (Heat shock protein 86), Q5FVH0 (unknown), P58405 (Striatin 3), Q62667 (Major vault protein), Q66H50 (unknown), Q09167 (splicing factor), Q9JHU5 (Arfaptin 1)."|comment:"Insulin increased GLUT4 interaction with the following proteins:Q9Z1P2 (R-actinin-1), P45592 (Cofilin), Q9QXQ0 (R-actinin-4), P26473 (ADP-ribosylation factor), P26437 (ADP-ribosylation factor),   Q7TNP1 (Basigin 2), Q6P6R2 (Dihydrolipoamide dehydrogenase),   P04797 (GAPDH), Q63081 (Protein disulfide isomerase), P29457 (47 kDa heat shock protein), Q9R1J8 (Leprecan), O88638 (Putative eps protein),   Q64375 (Synaptonemal complex)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:NDPK - Interactions involving proteins containing InterPro domain IPR001564, Nucleoside diphosphate kinase, core.	taxid:10116(rat-l6)|taxid:10116(Rattus norvegicus)	-	2006/02/15	2021/11/30	rogid:PbFY2lfrty8yw40Jq7ShR7xfuV410116	rogid:ptqIy3scl8hjZOu5DWFducDvmqY10116	intact-crc:44F3A2176D02515F|rigid:9RVm0UBcqQF4k06RGKO89Bg16Q8	false	myc tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P19357	uniprotkb:Q62991	intact:EBI-915426|uniprotkb:P97900|ensembl:ENSRNOP00000023256	intact:EBI-918383|uniprotkb:Q62843|intact:EBI-11702597|ensembl:ENSRNOP00000039132	psi-mi:glut4_rat(display_long)|uniprotkb:Glucose transporter type 4, insulin-responsive(gene name synonym)|uniprotkb:Slc2a4(gene name)|psi-mi:Slc2a4(display_short)|uniprotkb:Glut4(gene name synonym)	psi-mi:scfd1_rat(display_long)|uniprotkb:Syntaxin-binding protein 1-like 2(gene name synonym)|uniprotkb:Vesicle transport-related protein Ra410(gene name synonym)|uniprotkb:SLY1 homolog(gene name synonym)|uniprotkb:Scfd1(gene name)|psi-mi:Scfd1(display_short)|uniprotkb:Ra410(gene name synonym)|uniprotkb:Sly1(gene name synonym)|uniprotkb:Stxbp1l2(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Foster et al. (2006)	pubmed:16396496|mint:MINT-5218203	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-921030	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2711|refseq:NP_036883.1|refseq:XP_006246658.1|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007611"(learning or memory)|go:"GO:0007614"(short-term memory)|go:"GO:0007616"(long-term memory)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010021"(amylopectin biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031550"(positive regulation of brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044381"(glucose import in response to insulin stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046323"(glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0098694"(regulation of synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0098793"(presynapse)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002441("Glucose transporter, type 4 (GLUT4)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-189200|ensembl:ENSRNOG00000017226(gene)|ensembl:ENSRNOT00000023256(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)	rgd:619828|refseq:NP_062237.1|ensembl:ENSRNOG00000031203(gene)|ensembl:ENSRNOT00000040548(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0001666"(response to hypoxia)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005798"(Golgi-associated vesicle)|go:"GO:0005801"(cis-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006888"(endoplasmic reticulum to Golgi vesicle-mediated transport)|go:"GO:0006890"(retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum)|go:"GO:0006892"(post-Golgi vesicle-mediated transport)|go:"GO:0009636"(response to toxic substance)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0019905"(syntaxin binding)|go:"GO:0032580"(Golgi cisterna membrane)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0051223"(regulation of protein transport)|go:"GO:0060628"(regulation of ER to Golgi vesicle-mediated transport)|go:"GO:1901998"(toxin transport)|go:"GO:1902902"(negative regulation of autophagosome assembly)|interpro:IPR001619(Sec1-like protein)|interpro:IPR027482|interpro:IPR036045|interpro:IPR043127|interpro:IPR043154|rcsb pdb:1Y9J|reactome:R-RNO-204005|reactome:R-RNO-8980692	-	-	-	caution:"The participant EBI-349571(P68370) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919386(Q7TP47) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920972(Q5XIP9) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-916419(P11980) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919578(Q8R491) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920554(Q5U3Z7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920647(Q5U2X8) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920585(Q7TP24) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-779677(P05426) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-915744(P02454) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|agonist:Insulin was shown to increase or decrease GLUT4 protein interactions in specific cases.|comment:"Insulin decreased GLUT4 interactions with the following proteins: Q9ER30 (Sarcosin), P09527 (Rab-7), O88960 (N-ethylmaleimide sensitive), P09456 (PKA I regulatory subunit), P27881 (Hexokinase type II), P07872 (Acyl-coenzyme A oxidase), Q6DGF1 (Isocitrate dehydrogenase), Q9EQX9 (Ubiquitin-conjugating), Q63446 (Polyubiquitin), P24268 (Cathepsin D), Q91XW0 (Heat shock protein 86), Q5FVH0 (unknown), P58405 (Striatin 3), Q62667 (Major vault protein), Q66H50 (unknown), Q09167 (splicing factor), Q9JHU5 (Arfaptin 1)."|comment:"Insulin increased GLUT4 interaction with the following proteins:Q9Z1P2 (R-actinin-1), P45592 (Cofilin), Q9QXQ0 (R-actinin-4), P26473 (ADP-ribosylation factor), P26437 (ADP-ribosylation factor),   Q7TNP1 (Basigin 2), Q6P6R2 (Dihydrolipoamide dehydrogenase),   P04797 (GAPDH), Q63081 (Protein disulfide isomerase), P29457 (47 kDa heat shock protein), Q9R1J8 (Leprecan), O88638 (Putative eps protein),   Q64375 (Synaptonemal complex)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:NDPK - Interactions involving proteins containing InterPro domain IPR001564, Nucleoside diphosphate kinase, core.	taxid:10116(rat-l6)|taxid:10116(Rattus norvegicus)	-	2006/02/15	2021/11/30	rogid:PbFY2lfrty8yw40Jq7ShR7xfuV410116	rogid:Zx6Xz6WSQHh9ZCPoD3YpL7FracI10116	intact-crc:44F3A2176D02515F|rigid:9RVm0UBcqQF4k06RGKO89Bg16Q8	false	myc tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P19357	uniprotkb:Q62786	intact:EBI-915426|uniprotkb:P97900|ensembl:ENSRNOP00000023256	intact:EBI-918371	psi-mi:glut4_rat(display_long)|uniprotkb:Glucose transporter type 4, insulin-responsive(gene name synonym)|uniprotkb:Slc2a4(gene name)|psi-mi:Slc2a4(display_short)|uniprotkb:Glut4(gene name synonym)	psi-mi:fprp_rat(display_long)|uniprotkb:Prostaglandin F2-alpha receptor regulatory protein(gene name synonym)|uniprotkb:Prostaglandin F2-alpha receptor-associated protein(gene name synonym)|uniprotkb:Ptgfrn(gene name)|psi-mi:Ptgfrn(display_short)|uniprotkb:Fprp(gene name synonym)|uniprotkb:CD9 partner 1(gene name synonym)|uniprotkb:Glu-Trp-Ile EWI motif-containing protein F(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Foster et al. (2006)	pubmed:16396496|mint:MINT-5218203	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-921030	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2711|refseq:NP_036883.1|refseq:XP_006246658.1|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007611"(learning or memory)|go:"GO:0007614"(short-term memory)|go:"GO:0007616"(long-term memory)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010021"(amylopectin biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031550"(positive regulation of brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044381"(glucose import in response to insulin stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046323"(glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0098694"(regulation of synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0098793"(presynapse)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002441("Glucose transporter, type 4 (GLUT4)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-189200|ensembl:ENSRNOG00000017226(gene)|ensembl:ENSRNOT00000023256(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)	rgd:3437|refseq:NP_062116.1|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR036179|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0014905"(myoblast fusion involved in skeletal muscle regeneration)|go:"GO:0016021"(integral component of membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0034389"(lipid droplet organization)	-	-	-	caution:"The participant EBI-349571(P68370) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919386(Q7TP47) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920972(Q5XIP9) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-916419(P11980) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919578(Q8R491) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920554(Q5U3Z7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920647(Q5U2X8) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920585(Q7TP24) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-779677(P05426) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-915744(P02454) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|agonist:Insulin was shown to increase or decrease GLUT4 protein interactions in specific cases.|comment:"Insulin decreased GLUT4 interactions with the following proteins: Q9ER30 (Sarcosin), P09527 (Rab-7), O88960 (N-ethylmaleimide sensitive), P09456 (PKA I regulatory subunit), P27881 (Hexokinase type II), P07872 (Acyl-coenzyme A oxidase), Q6DGF1 (Isocitrate dehydrogenase), Q9EQX9 (Ubiquitin-conjugating), Q63446 (Polyubiquitin), P24268 (Cathepsin D), Q91XW0 (Heat shock protein 86), Q5FVH0 (unknown), P58405 (Striatin 3), Q62667 (Major vault protein), Q66H50 (unknown), Q09167 (splicing factor), Q9JHU5 (Arfaptin 1)."|comment:"Insulin increased GLUT4 interaction with the following proteins:Q9Z1P2 (R-actinin-1), P45592 (Cofilin), Q9QXQ0 (R-actinin-4), P26473 (ADP-ribosylation factor), P26437 (ADP-ribosylation factor),   Q7TNP1 (Basigin 2), Q6P6R2 (Dihydrolipoamide dehydrogenase),   P04797 (GAPDH), Q63081 (Protein disulfide isomerase), P29457 (47 kDa heat shock protein), Q9R1J8 (Leprecan), O88638 (Putative eps protein),   Q64375 (Synaptonemal complex)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:NDPK - Interactions involving proteins containing InterPro domain IPR001564, Nucleoside diphosphate kinase, core.	taxid:10116(rat-l6)|taxid:10116(Rattus norvegicus)	-	2006/02/15	2021/11/30	rogid:PbFY2lfrty8yw40Jq7ShR7xfuV410116	rogid:Dk+ng4zWSdzanVSA6hhgPdGA9Do10116	intact-crc:44F3A2176D02515F|rigid:9RVm0UBcqQF4k06RGKO89Bg16Q8	false	myc tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P19357	uniprotkb:Q62764	intact:EBI-915426|uniprotkb:P97900|ensembl:ENSRNOP00000023256	intact:EBI-918348|uniprotkb:Q63748	psi-mi:glut4_rat(display_long)|uniprotkb:Glucose transporter type 4, insulin-responsive(gene name synonym)|uniprotkb:Slc2a4(gene name)|psi-mi:Slc2a4(display_short)|uniprotkb:Glut4(gene name synonym)	psi-mi:ybox3_rat(display_long)|uniprotkb:Ybx3(gene name)|psi-mi:Ybx3(display_short)|uniprotkb:Cold shock domain-containing protein A(gene name synonym)|uniprotkb:Csda(gene name synonym)|uniprotkb:DNA-binding protein A(gene name synonym)|uniprotkb:Dbpa(gene name synonym)|uniprotkb:Muscle Y-box protein YB2(gene name synonym)|uniprotkb:RYB-A(gene name synonym)|uniprotkb:Y-box-binding protein A(gene name synonym)|uniprotkb:Yb2(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Foster et al. (2006)	pubmed:16396496|mint:MINT-5218203	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-921030	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2711|refseq:NP_036883.1|refseq:XP_006246658.1|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007611"(learning or memory)|go:"GO:0007614"(short-term memory)|go:"GO:0007616"(long-term memory)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010021"(amylopectin biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031550"(positive regulation of brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044381"(glucose import in response to insulin stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046323"(glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0098694"(regulation of synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0098793"(presynapse)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002441("Glucose transporter, type 4 (GLUT4)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-189200|ensembl:ENSRNOG00000017226(gene)|ensembl:ENSRNOT00000023256(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)	rgd:621056|interpro:IPR019844|interpro:IPR011129(Cold shock protein)|interpro:IPR002059(Cold-shock protein, DNA-binding)|interpro:IPR012340(Nucleic acid-binding, OB-fold)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0003676"(nucleic acid binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005921"(gap junction)|go:"GO:0007283"(spermatogenesis)|go:"GO:0008584"(male gonad development)|go:"GO:0009566"(fertilization)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0031100"(animal organ regeneration)|go:"GO:0043021"(ribonucleoprotein complex binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0046622"(positive regulation of organ growth)|go:"GO:0048642"(negative regulation of skeletal muscle tissue development)|go:"GO:0060546"(negative regulation of necroptotic process)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071474"(cellular hyperosmotic response)|go:"GO:1902219"(negative regulation of intrinsic apoptotic signaling pathway in response to osmotic stress)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|refseq:NP_114185.3|go:"GO:1905538"(polysome binding)	-	-	-	caution:"The participant EBI-349571(P68370) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919386(Q7TP47) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920972(Q5XIP9) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-916419(P11980) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919578(Q8R491) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920554(Q5U3Z7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920647(Q5U2X8) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920585(Q7TP24) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-779677(P05426) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-915744(P02454) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|agonist:Insulin was shown to increase or decrease GLUT4 protein interactions in specific cases.|comment:"Insulin decreased GLUT4 interactions with the following proteins: Q9ER30 (Sarcosin), P09527 (Rab-7), O88960 (N-ethylmaleimide sensitive), P09456 (PKA I regulatory subunit), P27881 (Hexokinase type II), P07872 (Acyl-coenzyme A oxidase), Q6DGF1 (Isocitrate dehydrogenase), Q9EQX9 (Ubiquitin-conjugating), Q63446 (Polyubiquitin), P24268 (Cathepsin D), Q91XW0 (Heat shock protein 86), Q5FVH0 (unknown), P58405 (Striatin 3), Q62667 (Major vault protein), Q66H50 (unknown), Q09167 (splicing factor), Q9JHU5 (Arfaptin 1)."|comment:"Insulin increased GLUT4 interaction with the following proteins:Q9Z1P2 (R-actinin-1), P45592 (Cofilin), Q9QXQ0 (R-actinin-4), P26473 (ADP-ribosylation factor), P26437 (ADP-ribosylation factor),   Q7TNP1 (Basigin 2), Q6P6R2 (Dihydrolipoamide dehydrogenase),   P04797 (GAPDH), Q63081 (Protein disulfide isomerase), P29457 (47 kDa heat shock protein), Q9R1J8 (Leprecan), O88638 (Putative eps protein),   Q64375 (Synaptonemal complex)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:NDPK - Interactions involving proteins containing InterPro domain IPR001564, Nucleoside diphosphate kinase, core.	taxid:10116(rat-l6)|taxid:10116(Rattus norvegicus)	-	2006/02/15	2021/11/30	rogid:PbFY2lfrty8yw40Jq7ShR7xfuV410116	rogid:Y95Rasjqc6X93yx/Fg2uF7R+hJw10116	intact-crc:44F3A2176D02515F|rigid:9RVm0UBcqQF4k06RGKO89Bg16Q8	false	myc tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P19357	uniprotkb:Q62698	intact:EBI-915426|uniprotkb:P97900|ensembl:ENSRNOP00000023256	intact:EBI-918338|ensembl:ENSRNOP00000029646	psi-mi:glut4_rat(display_long)|uniprotkb:Glucose transporter type 4, insulin-responsive(gene name synonym)|uniprotkb:Slc2a4(gene name)|psi-mi:Slc2a4(display_short)|uniprotkb:Glut4(gene name synonym)	psi-mi:dc1l2_rat(display_long)|uniprotkb:Dynein light intermediate chain 2, cytosolic(gene name synonym)|uniprotkb:LIC53/55(gene name synonym)|uniprotkb:Dync1li2(gene name)|psi-mi:Dync1li2(display_short)|uniprotkb:Dncli2(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Foster et al. (2006)	pubmed:16396496|mint:MINT-5218203	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-921030	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2711|refseq:NP_036883.1|refseq:XP_006246658.1|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007611"(learning or memory)|go:"GO:0007614"(short-term memory)|go:"GO:0007616"(long-term memory)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010021"(amylopectin biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031550"(positive regulation of brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044381"(glucose import in response to insulin stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046323"(glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0098694"(regulation of synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0098793"(presynapse)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002441("Glucose transporter, type 4 (GLUT4)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-189200|ensembl:ENSRNOG00000017226(gene)|ensembl:ENSRNOT00000023256(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)	rgd:621130|refseq:NP_112288.1|ensembl:ENSRNOG00000025791(gene)|ensembl:ENSRNOT00000034472(transcript)|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0000776"(kinetochore)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005868"(cytoplasmic dynein complex)|go:"GO:0005874"(microtubule)|go:"GO:0007018"(microtubule-based movement)|go:"GO:0042802"(identical protein binding)|go:"GO:0045504"(dynein heavy chain binding)|go:"GO:0051642"(centrosome localization)|go:"GO:1990090"(cellular response to nerve growth factor stimulus)|interpro:IPR008467(Dynein light intermediate chain)|interpro:IPR022780|interpro:IPR027417|reactome:R-RNO-141444|reactome:R-RNO-2132295|reactome:R-RNO-2467813|reactome:R-RNO-2500257|reactome:R-RNO-3371497|reactome:R-RNO-5663220|reactome:R-RNO-6807878|reactome:R-RNO-6811436|reactome:R-RNO-68877|reactome:R-RNO-9646399|reactome:R-RNO-9648025	-	-	-	caution:"The participant EBI-349571(P68370) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919386(Q7TP47) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920972(Q5XIP9) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-916419(P11980) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919578(Q8R491) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920554(Q5U3Z7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920647(Q5U2X8) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920585(Q7TP24) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-779677(P05426) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-915744(P02454) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|agonist:Insulin was shown to increase or decrease GLUT4 protein interactions in specific cases.|comment:"Insulin decreased GLUT4 interactions with the following proteins: Q9ER30 (Sarcosin), P09527 (Rab-7), O88960 (N-ethylmaleimide sensitive), P09456 (PKA I regulatory subunit), P27881 (Hexokinase type II), P07872 (Acyl-coenzyme A oxidase), Q6DGF1 (Isocitrate dehydrogenase), Q9EQX9 (Ubiquitin-conjugating), Q63446 (Polyubiquitin), P24268 (Cathepsin D), Q91XW0 (Heat shock protein 86), Q5FVH0 (unknown), P58405 (Striatin 3), Q62667 (Major vault protein), Q66H50 (unknown), Q09167 (splicing factor), Q9JHU5 (Arfaptin 1)."|comment:"Insulin increased GLUT4 interaction with the following proteins:Q9Z1P2 (R-actinin-1), P45592 (Cofilin), Q9QXQ0 (R-actinin-4), P26473 (ADP-ribosylation factor), P26437 (ADP-ribosylation factor),   Q7TNP1 (Basigin 2), Q6P6R2 (Dihydrolipoamide dehydrogenase),   P04797 (GAPDH), Q63081 (Protein disulfide isomerase), P29457 (47 kDa heat shock protein), Q9R1J8 (Leprecan), O88638 (Putative eps protein),   Q64375 (Synaptonemal complex)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:NDPK - Interactions involving proteins containing InterPro domain IPR001564, Nucleoside diphosphate kinase, core.	taxid:10116(rat-l6)|taxid:10116(Rattus norvegicus)	-	2006/02/15	2021/11/30	rogid:PbFY2lfrty8yw40Jq7ShR7xfuV410116	rogid:qhxjWpRMzP20tgzGkZPQIgnTlrM10116	intact-crc:44F3A2176D02515F|rigid:9RVm0UBcqQF4k06RGKO89Bg16Q8	false	myc tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P19357	uniprotkb:Q62667	intact:EBI-915426|uniprotkb:P97900|ensembl:ENSRNOP00000023256	intact:EBI-918333	psi-mi:glut4_rat(display_long)|uniprotkb:Glucose transporter type 4, insulin-responsive(gene name synonym)|uniprotkb:Slc2a4(gene name)|psi-mi:Slc2a4(display_short)|uniprotkb:Glut4(gene name synonym)	psi-mi:mvp_rat(display_long)|uniprotkb:Mvp(gene name)|psi-mi:Mvp(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Foster et al. (2006)	pubmed:16396496|mint:MINT-5218203	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-921030	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2711|refseq:NP_036883.1|refseq:XP_006246658.1|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007611"(learning or memory)|go:"GO:0007614"(short-term memory)|go:"GO:0007616"(long-term memory)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010021"(amylopectin biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031550"(positive regulation of brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044381"(glucose import in response to insulin stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046323"(glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0098694"(regulation of synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0098793"(presynapse)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002441("Glucose transporter, type 4 (GLUT4)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-189200|ensembl:ENSRNOG00000017226(gene)|ensembl:ENSRNOT00000023256(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)	rgd:70932|refseq:NP_073206.2|dip:DIP-29532N|reactome:R-RNO-6798695|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005856"(cytoskeleton)|go:"GO:0008283"(cell population proliferation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0031953"(negative regulation of protein autophosphorylation)|go:"GO:0038127"(ERBB signaling pathway)|go:"GO:0042059"(negative regulation of epidermal growth factor receptor signaling pathway)|go:"GO:0042802"(identical protein binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0061099"(negative regulation of protein tyrosine kinase activity)|go:"GO:0072376"(protein activation cascade)|interpro:IPR002499(Major vault protein, N-terminal)|interpro:IPR021870|interpro:IPR036013|interpro:IPR039059|interpro:IPR040989|interpro:IPR041134|interpro:IPR041136|interpro:IPR041139|interpro:IPR043023|interpro:IPR043179|rcsb pdb:2QZV|rcsb pdb:4HL8|rcsb pdb:4V60|rcsb pdb:6BP7|rcsb pdb:6BP8	-	-	-	caution:"The participant EBI-349571(P68370) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919386(Q7TP47) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920972(Q5XIP9) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-916419(P11980) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919578(Q8R491) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920554(Q5U3Z7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920647(Q5U2X8) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920585(Q7TP24) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-779677(P05426) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-915744(P02454) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|agonist:Insulin was shown to increase or decrease GLUT4 protein interactions in specific cases.|comment:"Insulin decreased GLUT4 interactions with the following proteins: Q9ER30 (Sarcosin), P09527 (Rab-7), O88960 (N-ethylmaleimide sensitive), P09456 (PKA I regulatory subunit), P27881 (Hexokinase type II), P07872 (Acyl-coenzyme A oxidase), Q6DGF1 (Isocitrate dehydrogenase), Q9EQX9 (Ubiquitin-conjugating), Q63446 (Polyubiquitin), P24268 (Cathepsin D), Q91XW0 (Heat shock protein 86), Q5FVH0 (unknown), P58405 (Striatin 3), Q62667 (Major vault protein), Q66H50 (unknown), Q09167 (splicing factor), Q9JHU5 (Arfaptin 1)."|comment:"Insulin increased GLUT4 interaction with the following proteins:Q9Z1P2 (R-actinin-1), P45592 (Cofilin), Q9QXQ0 (R-actinin-4), P26473 (ADP-ribosylation factor), P26437 (ADP-ribosylation factor),   Q7TNP1 (Basigin 2), Q6P6R2 (Dihydrolipoamide dehydrogenase),   P04797 (GAPDH), Q63081 (Protein disulfide isomerase), P29457 (47 kDa heat shock protein), Q9R1J8 (Leprecan), O88638 (Putative eps protein),   Q64375 (Synaptonemal complex)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:NDPK - Interactions involving proteins containing InterPro domain IPR001564, Nucleoside diphosphate kinase, core.	taxid:10116(rat-l6)|taxid:10116(Rattus norvegicus)	-	2006/02/15	2021/11/30	rogid:PbFY2lfrty8yw40Jq7ShR7xfuV410116	rogid:2E2MhC4ZNFoYaCO9k6yK3IdOz4s10116	intact-crc:44F3A2176D02515F|rigid:9RVm0UBcqQF4k06RGKO89Bg16Q8	false	myc tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P19357	uniprotkb:Q62638	intact:EBI-915426|uniprotkb:P97900|ensembl:ENSRNOP00000023256	intact:EBI-918325	psi-mi:glut4_rat(display_long)|uniprotkb:Glucose transporter type 4, insulin-responsive(gene name synonym)|uniprotkb:Slc2a4(gene name)|psi-mi:Slc2a4(display_short)|uniprotkb:Glut4(gene name synonym)	psi-mi:gslg1_rat(display_long)|uniprotkb:Glg1(gene name)|psi-mi:Glg1(display_short)|uniprotkb:Esl1(gene name synonym)|uniprotkb:Mg160(gene name synonym)|uniprotkb:Golgi sialoglycoprotein MG-160(gene name synonym)|uniprotkb:E-selectin ligand 1(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Foster et al. (2006)	pubmed:16396496|mint:MINT-5218203	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-921030	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2711|refseq:NP_036883.1|refseq:XP_006246658.1|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007611"(learning or memory)|go:"GO:0007614"(short-term memory)|go:"GO:0007616"(long-term memory)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010021"(amylopectin biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031550"(positive regulation of brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044381"(glucose import in response to insulin stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046323"(glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0098694"(regulation of synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0098793"(presynapse)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002441("Glucose transporter, type 4 (GLUT4)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-189200|ensembl:ENSRNOG00000017226(gene)|ensembl:ENSRNOT00000023256(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)	rgd:69345|refseq:NP_058907.1|interpro:IPR001893(Cysteine rich repeat)|interpro:IPR017873|interpro:IPR039728|reactome:R-RNO-202733|go:"GO:0000139"(Golgi membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005797"(Golgi medial cisterna)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0010955"(negative regulation of protein processing)|go:"GO:0016021"(integral component of membrane)|go:"GO:0017134"(fibroblast growth factor binding)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0031012"(extracellular matrix)|go:"GO:0032330"(regulation of chondrocyte differentiation)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0060349"(bone morphogenesis)	-	-	-	caution:"The participant EBI-349571(P68370) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919386(Q7TP47) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920972(Q5XIP9) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-916419(P11980) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919578(Q8R491) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920554(Q5U3Z7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920647(Q5U2X8) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920585(Q7TP24) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-779677(P05426) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-915744(P02454) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|agonist:Insulin was shown to increase or decrease GLUT4 protein interactions in specific cases.|comment:"Insulin decreased GLUT4 interactions with the following proteins: Q9ER30 (Sarcosin), P09527 (Rab-7), O88960 (N-ethylmaleimide sensitive), P09456 (PKA I regulatory subunit), P27881 (Hexokinase type II), P07872 (Acyl-coenzyme A oxidase), Q6DGF1 (Isocitrate dehydrogenase), Q9EQX9 (Ubiquitin-conjugating), Q63446 (Polyubiquitin), P24268 (Cathepsin D), Q91XW0 (Heat shock protein 86), Q5FVH0 (unknown), P58405 (Striatin 3), Q62667 (Major vault protein), Q66H50 (unknown), Q09167 (splicing factor), Q9JHU5 (Arfaptin 1)."|comment:"Insulin increased GLUT4 interaction with the following proteins:Q9Z1P2 (R-actinin-1), P45592 (Cofilin), Q9QXQ0 (R-actinin-4), P26473 (ADP-ribosylation factor), P26437 (ADP-ribosylation factor),   Q7TNP1 (Basigin 2), Q6P6R2 (Dihydrolipoamide dehydrogenase),   P04797 (GAPDH), Q63081 (Protein disulfide isomerase), P29457 (47 kDa heat shock protein), Q9R1J8 (Leprecan), O88638 (Putative eps protein),   Q64375 (Synaptonemal complex)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:NDPK - Interactions involving proteins containing InterPro domain IPR001564, Nucleoside diphosphate kinase, core.	taxid:10116(rat-l6)|taxid:10116(Rattus norvegicus)	-	2006/02/15	2021/11/30	rogid:PbFY2lfrty8yw40Jq7ShR7xfuV410116	rogid:woGCg+M6uG8bOV08b/aj9cicve410116	intact-crc:44F3A2176D02515F|rigid:9RVm0UBcqQF4k06RGKO89Bg16Q8	false	myc tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P19357	uniprotkb:Q60587	intact:EBI-915426|uniprotkb:P97900|ensembl:ENSRNOP00000023256	intact:EBI-918320|ensembl:ENSRNOP00000014637	psi-mi:glut4_rat(display_long)|uniprotkb:Glucose transporter type 4, insulin-responsive(gene name synonym)|uniprotkb:Slc2a4(gene name)|psi-mi:Slc2a4(display_short)|uniprotkb:Glut4(gene name synonym)	psi-mi:echb_rat(display_long)|uniprotkb:Hadhb(gene name)|psi-mi:Hadhb(display_short)|uniprotkb:TP-beta(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Foster et al. (2006)	pubmed:16396496|mint:MINT-5218203	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-921030	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2711|refseq:NP_036883.1|refseq:XP_006246658.1|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007611"(learning or memory)|go:"GO:0007614"(short-term memory)|go:"GO:0007616"(long-term memory)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010021"(amylopectin biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031550"(positive regulation of brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044381"(glucose import in response to insulin stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046323"(glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0098694"(regulation of synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0098793"(presynapse)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002441("Glucose transporter, type 4 (GLUT4)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-189200|ensembl:ENSRNOG00000017226(gene)|ensembl:ENSRNOT00000023256(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)	rgd:620513|refseq:NP_598302.1|refseq:XP_006239848.2|refseq:XP_006239850.1|refseq:XP_006239851.1|ensembl:ENSRNOG00000010800(gene)|ensembl:ENSRNOT00000014637(transcript)|go:"GO:0003988"(acetyl-CoA C-acyltransferase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0006635"(fatty acid beta-oxidation)|go:"GO:0016507"(mitochondrial fatty acid beta-oxidation multienzyme complex)|go:"GO:0042645"(mitochondrial nucleoid)|go:"GO:0044877"(protein-containing complex binding)|interpro:IPR002155(Thiolase)|interpro:IPR016039(Thiolase-like)|interpro:IPR020610|interpro:IPR020613|interpro:IPR020615|interpro:IPR020616|interpro:IPR020617|mint:Q60587|reactome:R-RNO-1482798|reactome:R-RNO-77285|reactome:R-RNO-77305|reactome:R-RNO-77310|reactome:R-RNO-77346|reactome:R-RNO-77348|reactome:R-RNO-77350|go:"GO:0050633"(acetyl-CoA C-myristoyltransferase activity)	-	-	-	caution:"The participant EBI-349571(P68370) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919386(Q7TP47) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920972(Q5XIP9) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-916419(P11980) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919578(Q8R491) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920554(Q5U3Z7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920647(Q5U2X8) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920585(Q7TP24) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-779677(P05426) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-915744(P02454) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|agonist:Insulin was shown to increase or decrease GLUT4 protein interactions in specific cases.|comment:"Insulin decreased GLUT4 interactions with the following proteins: Q9ER30 (Sarcosin), P09527 (Rab-7), O88960 (N-ethylmaleimide sensitive), P09456 (PKA I regulatory subunit), P27881 (Hexokinase type II), P07872 (Acyl-coenzyme A oxidase), Q6DGF1 (Isocitrate dehydrogenase), Q9EQX9 (Ubiquitin-conjugating), Q63446 (Polyubiquitin), P24268 (Cathepsin D), Q91XW0 (Heat shock protein 86), Q5FVH0 (unknown), P58405 (Striatin 3), Q62667 (Major vault protein), Q66H50 (unknown), Q09167 (splicing factor), Q9JHU5 (Arfaptin 1)."|comment:"Insulin increased GLUT4 interaction with the following proteins:Q9Z1P2 (R-actinin-1), P45592 (Cofilin), Q9QXQ0 (R-actinin-4), P26473 (ADP-ribosylation factor), P26437 (ADP-ribosylation factor),   Q7TNP1 (Basigin 2), Q6P6R2 (Dihydrolipoamide dehydrogenase),   P04797 (GAPDH), Q63081 (Protein disulfide isomerase), P29457 (47 kDa heat shock protein), Q9R1J8 (Leprecan), O88638 (Putative eps protein),   Q64375 (Synaptonemal complex)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:NDPK - Interactions involving proteins containing InterPro domain IPR001564, Nucleoside diphosphate kinase, core.	taxid:10116(rat-l6)|taxid:10116(Rattus norvegicus)	-	2006/02/15	2021/11/30	rogid:PbFY2lfrty8yw40Jq7ShR7xfuV410116	rogid:EEoW64ViK5odTwXLkE6zQWJgIAw10116	intact-crc:44F3A2176D02515F|rigid:9RVm0UBcqQF4k06RGKO89Bg16Q8	false	myc tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P19357	uniprotkb:P62997	intact:EBI-915426|uniprotkb:P97900|ensembl:ENSRNOP00000023256	intact:EBI-918308|uniprotkb:O15449|uniprotkb:Q15815|uniprotkb:Q64283|ensembl:ENSRNOP00000002429	psi-mi:glut4_rat(display_long)|uniprotkb:Glucose transporter type 4, insulin-responsive(gene name synonym)|uniprotkb:Slc2a4(gene name)|psi-mi:Slc2a4(display_short)|uniprotkb:Glut4(gene name synonym)	psi-mi:tra2b_rat(display_long)|uniprotkb:Tra2b(gene name)|psi-mi:Tra2b(display_short)|uniprotkb:Sfrs10(gene name synonym)|uniprotkb:Transformer-2 protein homolog B(gene name synonym)|uniprotkb:Splicing factor, arginine/serine-rich 10(gene name synonym)|uniprotkb:RA301(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Foster et al. (2006)	pubmed:16396496|mint:MINT-5218203	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-921030	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2711|refseq:NP_036883.1|refseq:XP_006246658.1|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007611"(learning or memory)|go:"GO:0007614"(short-term memory)|go:"GO:0007616"(long-term memory)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010021"(amylopectin biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031550"(positive regulation of brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044381"(glucose import in response to insulin stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046323"(glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0098694"(regulation of synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0098793"(presynapse)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002441("Glucose transporter, type 4 (GLUT4)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-189200|ensembl:ENSRNOG00000017226(gene)|ensembl:ENSRNOT00000023256(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)	rgd:619886|refseq:NP_476460.1|ensembl:ENSRNOG00000001783(gene)|ensembl:ENSRNOT00000002429(transcript)|go:"GO:0000302"(response to reactive oxygen species)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0003723"(RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005637"(nuclear inner membrane)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005681"(spliceosomal complex)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0021796"(cerebral cortex regionalization)|go:"GO:0032991"(protein-containing complex)|go:"GO:0036002"(pre-mRNA binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0043484"(regulation of RNA splicing)|go:"GO:0048026"(positive regulation of mRNA splicing, via spliceosome)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0071333"(cellular response to glucose stimulus)|go:"GO:1990403"(embryonic brain development)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR035979|reactome:R-RNO-72163|reactome:R-RNO-9013418|reactome:R-RNO-9013422	-	-	-	caution:"The participant EBI-349571(P68370) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919386(Q7TP47) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920972(Q5XIP9) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-916419(P11980) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919578(Q8R491) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920554(Q5U3Z7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920647(Q5U2X8) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920585(Q7TP24) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-779677(P05426) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-915744(P02454) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|agonist:Insulin was shown to increase or decrease GLUT4 protein interactions in specific cases.|comment:"Insulin decreased GLUT4 interactions with the following proteins: Q9ER30 (Sarcosin), P09527 (Rab-7), O88960 (N-ethylmaleimide sensitive), P09456 (PKA I regulatory subunit), P27881 (Hexokinase type II), P07872 (Acyl-coenzyme A oxidase), Q6DGF1 (Isocitrate dehydrogenase), Q9EQX9 (Ubiquitin-conjugating), Q63446 (Polyubiquitin), P24268 (Cathepsin D), Q91XW0 (Heat shock protein 86), Q5FVH0 (unknown), P58405 (Striatin 3), Q62667 (Major vault protein), Q66H50 (unknown), Q09167 (splicing factor), Q9JHU5 (Arfaptin 1)."|comment:"Insulin increased GLUT4 interaction with the following proteins:Q9Z1P2 (R-actinin-1), P45592 (Cofilin), Q9QXQ0 (R-actinin-4), P26473 (ADP-ribosylation factor), P26437 (ADP-ribosylation factor),   Q7TNP1 (Basigin 2), Q6P6R2 (Dihydrolipoamide dehydrogenase),   P04797 (GAPDH), Q63081 (Protein disulfide isomerase), P29457 (47 kDa heat shock protein), Q9R1J8 (Leprecan), O88638 (Putative eps protein),   Q64375 (Synaptonemal complex)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:NDPK - Interactions involving proteins containing InterPro domain IPR001564, Nucleoside diphosphate kinase, core.	taxid:10116(rat-l6)|taxid:10116(Rattus norvegicus)	-	2006/02/15	2021/11/30	rogid:PbFY2lfrty8yw40Jq7ShR7xfuV410116	rogid:6uZGeHEDlIVsb2uPeo+9NoR4tDw10116	intact-crc:44F3A2176D02515F|rigid:9RVm0UBcqQF4k06RGKO89Bg16Q8	false	myc tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P19357	uniprotkb:P63170	intact:EBI-915426|uniprotkb:P97900|ensembl:ENSRNOP00000023256	intact:EBI-349137|uniprotkb:Q15701|ensembl:ENSRNOP00000061342	psi-mi:glut4_rat(display_long)|uniprotkb:Glucose transporter type 4, insulin-responsive(gene name synonym)|uniprotkb:Slc2a4(gene name)|psi-mi:Slc2a4(display_short)|uniprotkb:Glut4(gene name synonym)	psi-mi:dyl1_rat(display_long)|uniprotkb:Dynll1(gene name)|psi-mi:Dynll1(display_short)|uniprotkb:Dnclc1(gene name synonym)|uniprotkb:Pin(gene name synonym)|uniprotkb:Dynein light chain LC8-type 1(gene name synonym)|uniprotkb:8 kDa dynein light chain(gene name synonym)|uniprotkb:Protein inhibitor of neuronal nitric oxide synthase(gene name synonym)|uniprotkb:Dncl1(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Foster et al. (2006)	pubmed:16396496|mint:MINT-5218203	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-921030	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2711|refseq:NP_036883.1|refseq:XP_006246658.1|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007611"(learning or memory)|go:"GO:0007614"(short-term memory)|go:"GO:0007616"(long-term memory)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010021"(amylopectin biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031550"(positive regulation of brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044381"(glucose import in response to insulin stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046323"(glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0098694"(regulation of synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0098793"(presynapse)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002441("Glucose transporter, type 4 (GLUT4)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-189200|ensembl:ENSRNOG00000017226(gene)|ensembl:ENSRNOT00000023256(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)	rgd:619866|refseq:NP_445771.1|reactome:R-RNO-3371497|reactome:R-RNO-380259|reactome:R-RNO-380270|reactome:R-RNO-380284|reactome:R-RNO-380320|reactome:R-RNO-5620912|reactome:R-RNO-5620924|reactome:R-RNO-5663220|reactome:R-RNO-6798695|reactome:R-RNO-6807878|reactome:R-RNO-6811436|reactome:R-RNO-68877|reactome:R-RNO-8854518|reactome:R-RNO-9646399|reactome:R-RNO-9648025|ensembl:ENSRNOG00000011222(gene)|ensembl:ENSRNOT00000014910(transcript)|go:"GO:0000776"(kinetochore)|go:"GO:0004857"(enzyme inhibitor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005868"(cytoplasmic dynein complex)|go:"GO:0005874"(microtubule)|go:"GO:0005929"(cilium)|go:"GO:0006809"(nitric oxide biosynthetic process)|go:"GO:0006915"(apoptotic process)|go:"GO:0007286"(spermatid development)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008180"(COP9 signalosome)|go:"GO:0016020"(membrane)|go:"GO:0019899"(enzyme binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030141"(secretory granule)|go:"GO:0030235"(nitric-oxide synthase regulator activity)|go:"GO:0030286"(dynein complex)|go:"GO:0035721"(intraciliary retrograde transport)|go:"GO:0035774"(positive regulation of insulin secretion involved in cellular response to glucose stimulus)|go:"GO:0042133"(neurotransmitter metabolic process)|go:"GO:0042326"(negative regulation of phosphorylation)|go:"GO:0042802"(identical protein binding)|go:"GO:0044458"(motile cilium assembly)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045019"(negative regulation of nitric oxide biosynthetic process)|go:"GO:0045505"(dynein intermediate chain binding)|go:"GO:0051959"(dynein light intermediate chain binding)|go:"GO:0060271"(cilium assembly)|go:"GO:0072686"(mitotic spindle)|go:"GO:0097110"(scaffold protein binding)|go:"GO:1902857"(positive regulation of non-motile cilium assembly)|go:"GO:1904115"(axon cytoplasm)|go:"GO:2000582"(obsolete positive regulation of microtubule motor activity, plus-end-directed)|interpro:IPR001372(Dynein light chain, type 1 and 2)|interpro:IPR019763|interpro:IPR037177|mint:P63170|rcsb pdb:1F3C|rcsb pdb:1F95|rcsb pdb:1F96|reactome:R-RNO-111446|reactome:R-RNO-141444|reactome:R-RNO-1632852|reactome:R-RNO-2132295|reactome:R-RNO-2467813|reactome:R-RNO-2500257|reactome:R-RNO-2565942	-	-	-	caution:"The participant EBI-349571(P68370) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919386(Q7TP47) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920972(Q5XIP9) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-916419(P11980) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919578(Q8R491) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920554(Q5U3Z7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920647(Q5U2X8) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920585(Q7TP24) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-779677(P05426) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-915744(P02454) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|agonist:Insulin was shown to increase or decrease GLUT4 protein interactions in specific cases.|comment:"Insulin decreased GLUT4 interactions with the following proteins: Q9ER30 (Sarcosin), P09527 (Rab-7), O88960 (N-ethylmaleimide sensitive), P09456 (PKA I regulatory subunit), P27881 (Hexokinase type II), P07872 (Acyl-coenzyme A oxidase), Q6DGF1 (Isocitrate dehydrogenase), Q9EQX9 (Ubiquitin-conjugating), Q63446 (Polyubiquitin), P24268 (Cathepsin D), Q91XW0 (Heat shock protein 86), Q5FVH0 (unknown), P58405 (Striatin 3), Q62667 (Major vault protein), Q66H50 (unknown), Q09167 (splicing factor), Q9JHU5 (Arfaptin 1)."|comment:"Insulin increased GLUT4 interaction with the following proteins:Q9Z1P2 (R-actinin-1), P45592 (Cofilin), Q9QXQ0 (R-actinin-4), P26473 (ADP-ribosylation factor), P26437 (ADP-ribosylation factor),   Q7TNP1 (Basigin 2), Q6P6R2 (Dihydrolipoamide dehydrogenase),   P04797 (GAPDH), Q63081 (Protein disulfide isomerase), P29457 (47 kDa heat shock protein), Q9R1J8 (Leprecan), O88638 (Putative eps protein),   Q64375 (Synaptonemal complex)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:NDPK - Interactions involving proteins containing InterPro domain IPR001564, Nucleoside diphosphate kinase, core.	taxid:10116(rat-l6)|taxid:10116(Rattus norvegicus)	-	2006/02/15	2021/11/30	rogid:PbFY2lfrty8yw40Jq7ShR7xfuV410116	rogid:Bra4LfaqYPMyo6xX9RD6G7Rdv8010116	intact-crc:44F3A2176D02515F|rigid:9RVm0UBcqQF4k06RGKO89Bg16Q8	false	myc tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P19357	uniprotkb:Q10758	intact:EBI-915426|uniprotkb:P97900|ensembl:ENSRNOP00000023256	intact:EBI-877046|ensembl:ENSRNOP00000029068|uniprotkb:Q5WPB3	psi-mi:glut4_rat(display_long)|uniprotkb:Glucose transporter type 4, insulin-responsive(gene name synonym)|uniprotkb:Slc2a4(gene name)|psi-mi:Slc2a4(display_short)|uniprotkb:Glut4(gene name synonym)	psi-mi:k2c8_rat(display_long)|uniprotkb:Keratin-8(gene name synonym)|uniprotkb:Cytokeratin-8(gene name synonym)|uniprotkb:Cytokeratin endo A(gene name synonym)|uniprotkb:Krt8(gene name)|psi-mi:Krt8(display_short)|uniprotkb:Krt2-8(gene name synonym)|uniprotkb:Type-II keratin Kb8(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Foster et al. (2006)	pubmed:16396496|mint:MINT-5218203	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-921030	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2711|refseq:NP_036883.1|refseq:XP_006246658.1|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007611"(learning or memory)|go:"GO:0007614"(short-term memory)|go:"GO:0007616"(long-term memory)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010021"(amylopectin biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031550"(positive regulation of brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044381"(glucose import in response to insulin stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046323"(glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0098694"(regulation of synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0098793"(presynapse)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002441("Glucose transporter, type 4 (GLUT4)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-189200|ensembl:ENSRNOG00000017226(gene)|ensembl:ENSRNOT00000023256(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)	ensembl:ENSRNOG00000009779(gene)|ensembl:ENSRNOT00000038480(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005882"(intermediate filament)|go:"GO:0005911"(cell-cell junction)|go:"GO:0016010"(dystrophin-associated glycoprotein complex)|go:"GO:0016327"(apicolateral plasma membrane)|go:"GO:0016363"(nuclear matrix)|go:"GO:0030018"(Z disc)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0042383"(sarcolemma)|go:"GO:0043034"(costamere)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045095"(keratin filament)|go:"GO:0045214"(sarcomere organization)|go:"GO:0051599"(response to hydrostatic pressure)|go:"GO:0051707"(response to other organism)|go:"GO:0060706"(cell differentiation involved in embryonic placenta development)|go:"GO:0071944"(cell periphery)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097191"(extrinsic apoptotic signaling pathway)|go:"GO:0097284"(hepatocyte apoptotic process)|interpro:IPR003054(Type II keratin)|interpro:IPR018039|interpro:IPR032444|interpro:IPR039008|mint:Q10758|reactome:R-RNO-6805567|reactome:R-RNO-6809371|rgd:2984|refseq:NP_955402.1	-	-	-	caution:"The participant EBI-349571(P68370) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919386(Q7TP47) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920972(Q5XIP9) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-916419(P11980) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919578(Q8R491) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920554(Q5U3Z7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920647(Q5U2X8) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920585(Q7TP24) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-779677(P05426) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-915744(P02454) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|agonist:Insulin was shown to increase or decrease GLUT4 protein interactions in specific cases.|comment:"Insulin decreased GLUT4 interactions with the following proteins: Q9ER30 (Sarcosin), P09527 (Rab-7), O88960 (N-ethylmaleimide sensitive), P09456 (PKA I regulatory subunit), P27881 (Hexokinase type II), P07872 (Acyl-coenzyme A oxidase), Q6DGF1 (Isocitrate dehydrogenase), Q9EQX9 (Ubiquitin-conjugating), Q63446 (Polyubiquitin), P24268 (Cathepsin D), Q91XW0 (Heat shock protein 86), Q5FVH0 (unknown), P58405 (Striatin 3), Q62667 (Major vault protein), Q66H50 (unknown), Q09167 (splicing factor), Q9JHU5 (Arfaptin 1)."|comment:"Insulin increased GLUT4 interaction with the following proteins:Q9Z1P2 (R-actinin-1), P45592 (Cofilin), Q9QXQ0 (R-actinin-4), P26473 (ADP-ribosylation factor), P26437 (ADP-ribosylation factor),   Q7TNP1 (Basigin 2), Q6P6R2 (Dihydrolipoamide dehydrogenase),   P04797 (GAPDH), Q63081 (Protein disulfide isomerase), P29457 (47 kDa heat shock protein), Q9R1J8 (Leprecan), O88638 (Putative eps protein),   Q64375 (Synaptonemal complex)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:NDPK - Interactions involving proteins containing InterPro domain IPR001564, Nucleoside diphosphate kinase, core.	taxid:10116(rat-l6)|taxid:10116(Rattus norvegicus)	-	2006/02/15	2021/11/30	rogid:PbFY2lfrty8yw40Jq7ShR7xfuV410116	rogid:ATpfAaPsbtrq1tTuSE8L8COOLBw10116	intact-crc:44F3A2176D02515F|rigid:9RVm0UBcqQF4k06RGKO89Bg16Q8	false	myc tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P19357	uniprotkb:Q10728	intact:EBI-915426|uniprotkb:P97900|ensembl:ENSRNOP00000023256	intact:EBI-918263|uniprotkb:Q62937|uniprotkb:Q9WU33	psi-mi:glut4_rat(display_long)|uniprotkb:Glucose transporter type 4, insulin-responsive(gene name synonym)|uniprotkb:Slc2a4(gene name)|psi-mi:Slc2a4(display_short)|uniprotkb:Glut4(gene name synonym)	psi-mi:mypt1_rat(display_long)|uniprotkb:Ppp1r12a(gene name)|psi-mi:Ppp1r12a(display_short)|uniprotkb:Mbs(gene name synonym)|uniprotkb:Mypt1(gene name synonym)|uniprotkb:Myosin phosphatase-targeting subunit 1(gene name synonym)|uniprotkb:Protein phosphatase myosin-binding subunit(gene name synonym)|uniprotkb:MBSP(gene name synonym)|uniprotkb:Serine/threonine protein phosphatase PP1 smooth muscle regulatory subunit M110(gene name synonym)|uniprotkb:Protein phosphatase subunit 1M(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Foster et al. (2006)	pubmed:16396496|mint:MINT-5218203	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-921030	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2711|refseq:NP_036883.1|refseq:XP_006246658.1|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007611"(learning or memory)|go:"GO:0007614"(short-term memory)|go:"GO:0007616"(long-term memory)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010021"(amylopectin biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031550"(positive regulation of brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044381"(glucose import in response to insulin stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046323"(glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0098694"(regulation of synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0098793"(presynapse)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002441("Glucose transporter, type 4 (GLUT4)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-189200|ensembl:ENSRNOG00000017226(gene)|ensembl:ENSRNOT00000023256(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)	rgd:620013|refseq:NP_446342.1|interpro:IPR002110(Ankyrin)|interpro:IPR020683|interpro:IPR031775|refseq:XP_006241377.1|interpro:IPR017401(Protein phosphatase 1, regulatory subunits 12A/B/C, eukaryote)|interpro:IPR036770|reactome:R-RNO-2565942|reactome:R-RNO-5625740|reactome:R-RNO-5627123|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0000776"(kinetochore)|go:"GO:0004721"(phosphoprotein phosphatase activity)|go:"GO:0004857"(enzyme inhibitor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0007098"(centrosome cycle)|go:"GO:0007165"(signal transduction)|go:"GO:0019208"(phosphatase regulator activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030018"(Z disc)|go:"GO:0030155"(regulation of cell adhesion)|go:"GO:0031672"(A band)|go:"GO:0035507"(regulation of myosin-light-chain-phosphatase activity)|go:"GO:0035508"(positive regulation of myosin-light-chain-phosphatase activity)|go:"GO:0035690"|go:"GO:0043086"(negative regulation of catalytic activity)|go:"GO:0043292"(contractile fiber)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046822"(regulation of nucleocytoplasmic transport)|go:"GO:0071889"(14-3-3 protein binding)|go:"GO:0072357"(PTW/PP1 phosphatase complex)	-	-	-	caution:"The participant EBI-349571(P68370) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919386(Q7TP47) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920972(Q5XIP9) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-916419(P11980) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919578(Q8R491) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920554(Q5U3Z7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920647(Q5U2X8) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920585(Q7TP24) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-779677(P05426) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-915744(P02454) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|agonist:Insulin was shown to increase or decrease GLUT4 protein interactions in specific cases.|comment:"Insulin decreased GLUT4 interactions with the following proteins: Q9ER30 (Sarcosin), P09527 (Rab-7), O88960 (N-ethylmaleimide sensitive), P09456 (PKA I regulatory subunit), P27881 (Hexokinase type II), P07872 (Acyl-coenzyme A oxidase), Q6DGF1 (Isocitrate dehydrogenase), Q9EQX9 (Ubiquitin-conjugating), Q63446 (Polyubiquitin), P24268 (Cathepsin D), Q91XW0 (Heat shock protein 86), Q5FVH0 (unknown), P58405 (Striatin 3), Q62667 (Major vault protein), Q66H50 (unknown), Q09167 (splicing factor), Q9JHU5 (Arfaptin 1)."|comment:"Insulin increased GLUT4 interaction with the following proteins:Q9Z1P2 (R-actinin-1), P45592 (Cofilin), Q9QXQ0 (R-actinin-4), P26473 (ADP-ribosylation factor), P26437 (ADP-ribosylation factor),   Q7TNP1 (Basigin 2), Q6P6R2 (Dihydrolipoamide dehydrogenase),   P04797 (GAPDH), Q63081 (Protein disulfide isomerase), P29457 (47 kDa heat shock protein), Q9R1J8 (Leprecan), O88638 (Putative eps protein),   Q64375 (Synaptonemal complex)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:NDPK - Interactions involving proteins containing InterPro domain IPR001564, Nucleoside diphosphate kinase, core.	taxid:10116(rat-l6)|taxid:10116(Rattus norvegicus)	-	2006/02/15	2021/11/30	rogid:PbFY2lfrty8yw40Jq7ShR7xfuV410116	rogid:C2cW3Wgc4JZQGtDsP1NgRkzEr1s10116	intact-crc:44F3A2176D02515F|rigid:9RVm0UBcqQF4k06RGKO89Bg16Q8	false	myc tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P19357	uniprotkb:Q09073	intact:EBI-915426|uniprotkb:P97900|ensembl:ENSRNOP00000023256	intact:EBI-918254|ensembl:ENSRNOP00000015913	psi-mi:glut4_rat(display_long)|uniprotkb:Glucose transporter type 4, insulin-responsive(gene name synonym)|uniprotkb:Slc2a4(gene name)|psi-mi:Slc2a4(display_short)|uniprotkb:Glut4(gene name synonym)	psi-mi:adt2_rat(display_long)|uniprotkb:Slc25a5(gene name)|psi-mi:Slc25a5(display_short)|uniprotkb:Ant2(gene name synonym)|uniprotkb:Adenine nucleotide translocator 2(gene name synonym)|uniprotkb:ADP,ATP carrier protein 2(gene name synonym)|uniprotkb:Solute carrier family 25 member 5(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Foster et al. (2006)	pubmed:16396496|mint:MINT-5218203	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-921030	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2711|refseq:NP_036883.1|refseq:XP_006246658.1|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007611"(learning or memory)|go:"GO:0007614"(short-term memory)|go:"GO:0007616"(long-term memory)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010021"(amylopectin biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031550"(positive regulation of brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044381"(glucose import in response to insulin stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046323"(glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0098694"(regulation of synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0098793"(presynapse)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002441("Glucose transporter, type 4 (GLUT4)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-189200|ensembl:ENSRNOG00000017226(gene)|ensembl:ENSRNOT00000023256(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)	rgd:620353|refseq:NP_476443.1|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005757"(mitochondrial permeability transition pore complex)|go:"GO:0007059"(chromosome segregation)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0015078"(proton transmembrane transporter activity)|go:"GO:0016020"(membrane)|go:"GO:0017077"(oxidative phosphorylation uncoupler activity)|go:"GO:0030183"(B cell differentiation)|go:"GO:0030218"(erythrocyte differentiation)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0042645"(mitochondrial nucleoid)|go:"GO:0045121"(membrane raft)|go:"GO:0046902"(regulation of mitochondrial membrane permeability)|go:"GO:0051503"(adenine nucleotide transport)|go:"GO:0071817"(MMXD complex)|go:"GO:0140021"(mitochondrial ADP transmembrane transport)|go:"GO:1901029"(negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway)|go:"GO:1901526"(positive regulation of mitophagy)|go:"GO:1990544"(mitochondrial ATP transmembrane transport)|go:"GO:1990830"(cellular response to leukemia inhibitory factor)|go:"GO:1990845"(adaptive thermogenesis)|interpro:IPR002067(Mitochondrial carrier protein)|interpro:IPR002113(Adenine nucleotide translocator 1)|interpro:IPR018108|interpro:IPR023395|mint:Q09073|reactome:R-RNO-83936|go:"GO:0005471"("ATP:ADP antiporter activity")|ensembl:ENSRNOG00000039980(gene)|ensembl:ENSRNOT00000015085(transcript)|go:"GO:0000295"(adenine nucleotide transmembrane transporter activity)	-	-	-	caution:"The participant EBI-349571(P68370) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919386(Q7TP47) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920972(Q5XIP9) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-916419(P11980) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919578(Q8R491) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920554(Q5U3Z7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920647(Q5U2X8) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920585(Q7TP24) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-779677(P05426) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-915744(P02454) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|agonist:Insulin was shown to increase or decrease GLUT4 protein interactions in specific cases.|comment:"Insulin decreased GLUT4 interactions with the following proteins: Q9ER30 (Sarcosin), P09527 (Rab-7), O88960 (N-ethylmaleimide sensitive), P09456 (PKA I regulatory subunit), P27881 (Hexokinase type II), P07872 (Acyl-coenzyme A oxidase), Q6DGF1 (Isocitrate dehydrogenase), Q9EQX9 (Ubiquitin-conjugating), Q63446 (Polyubiquitin), P24268 (Cathepsin D), Q91XW0 (Heat shock protein 86), Q5FVH0 (unknown), P58405 (Striatin 3), Q62667 (Major vault protein), Q66H50 (unknown), Q09167 (splicing factor), Q9JHU5 (Arfaptin 1)."|comment:"Insulin increased GLUT4 interaction with the following proteins:Q9Z1P2 (R-actinin-1), P45592 (Cofilin), Q9QXQ0 (R-actinin-4), P26473 (ADP-ribosylation factor), P26437 (ADP-ribosylation factor),   Q7TNP1 (Basigin 2), Q6P6R2 (Dihydrolipoamide dehydrogenase),   P04797 (GAPDH), Q63081 (Protein disulfide isomerase), P29457 (47 kDa heat shock protein), Q9R1J8 (Leprecan), O88638 (Putative eps protein),   Q64375 (Synaptonemal complex)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:NDPK - Interactions involving proteins containing InterPro domain IPR001564, Nucleoside diphosphate kinase, core.	taxid:10116(rat-l6)|taxid:10116(Rattus norvegicus)	-	2006/02/15	2021/11/30	rogid:PbFY2lfrty8yw40Jq7ShR7xfuV410116	rogid:WdaA9kTxHaJrlP00OIJCP15jMpI10116	intact-crc:44F3A2176D02515F|rigid:9RVm0UBcqQF4k06RGKO89Bg16Q8	false	myc tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P19357	uniprotkb:Q08850	intact:EBI-915426|uniprotkb:P97900|ensembl:ENSRNOP00000023256	intact:EBI-918243|uniprotkb:G3V8I4|ensembl:ENSRNOP00000026224|ensembl:ENSRNOP00000074754	psi-mi:glut4_rat(display_long)|uniprotkb:Glucose transporter type 4, insulin-responsive(gene name synonym)|uniprotkb:Slc2a4(gene name)|psi-mi:Slc2a4(display_short)|uniprotkb:Glut4(gene name synonym)	psi-mi:stx4_rat(display_long)|uniprotkb:Stx4(gene name)|psi-mi:Stx4(display_short)|uniprotkb:Stx4a(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Foster et al. (2006)	pubmed:16396496|mint:MINT-5218203	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-921030	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2711|refseq:NP_036883.1|refseq:XP_006246658.1|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007611"(learning or memory)|go:"GO:0007614"(short-term memory)|go:"GO:0007616"(long-term memory)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010021"(amylopectin biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031550"(positive regulation of brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044381"(glucose import in response to insulin stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046323"(glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0098694"(regulation of synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0098793"(presynapse)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002441("Glucose transporter, type 4 (GLUT4)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-189200|ensembl:ENSRNOG00000017226(gene)|ensembl:ENSRNOT00000023256(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)	rgd:621019|refseq:NP_112387.1|dip:DIP-373N|ensembl:ENSRNOG00000019302(gene)|ensembl:ENSRNOT00000026224(transcript)|ensembl:ENSRNOT00000082121(transcript)|go:"GO:0000149"(SNARE binding)|go:"GO:0000322"(storage vacuole)|go:"GO:0002639"(positive regulation of immunoglobulin production)|go:"GO:0005484"(SNAP receptor activity)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005886"(plasma membrane)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006887"(exocytosis)|go:"GO:0006906"(vesicle fusion)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009986"(cell surface)|go:"GO:0012505"(endomembrane system)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016081"(synaptic vesicle docking)|go:"GO:0016230"(sphingomyelin phosphodiesterase activator activity)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0017157"(regulation of exocytosis)|go:"GO:0030027"(lamellipodium)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030507"(spectrin binding)|go:"GO:0031201"(SNARE complex)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031629"(synaptic vesicle fusion to presynaptic active zone membrane)|go:"GO:0032589"(neuron projection membrane)|go:"GO:0034394"(protein localization to cell surface)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0035493"(SNARE complex assembly)|go:"GO:0035749"(myelin sheath adaxonal region)|go:"GO:0035774"(positive regulation of insulin secretion involved in cellular response to glucose stimulus)|go:"GO:0036477"(somatodendritic compartment)|go:"GO:0042383"(sarcolemma)|go:"GO:0042581"(specific granule)|go:"GO:0043085"(positive regulation of catalytic activity)|go:"GO:0043197"(dendritic spine)|go:"GO:0043219"(lateral loop)|go:"GO:0043311"(positive regulation of eosinophil degranulation)|go:"GO:0045202"(synapse)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0046907"(intracellular transport)|go:"GO:0048278"(vesicle docking)|go:"GO:0048284"(organelle fusion)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048787"(presynaptic active zone membrane)|go:"GO:0050921"(positive regulation of chemotaxis)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0061025"(membrane fusion)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0098794"(postsynapse)|go:"GO:0098967"(exocytic insertion of neurotransmitter receptor to postsynaptic membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099003"(vesicle-mediated transport in synapse)|go:"GO:1902041"(regulation of extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|go:"GO:1903575"(cornified envelope assembly)|go:"GO:2000010"(positive regulation of protein localization to cell surface)|interpro:IPR000727(Target SNARE coiled-coil region)|interpro:IPR006011(Syntaxin, N-terminal)|interpro:IPR006012(Syntaxin/epimorphin, conserved site)|interpro:IPR010989(t-SNARE)|reactome:R-RNO-114516|reactome:R-RNO-1236974|reactome:R-RNO-449836	-	-	-	caution:"The participant EBI-349571(P68370) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919386(Q7TP47) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920972(Q5XIP9) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-916419(P11980) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919578(Q8R491) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920554(Q5U3Z7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920647(Q5U2X8) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920585(Q7TP24) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-779677(P05426) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-915744(P02454) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|agonist:Insulin was shown to increase or decrease GLUT4 protein interactions in specific cases.|comment:"Insulin decreased GLUT4 interactions with the following proteins: Q9ER30 (Sarcosin), P09527 (Rab-7), O88960 (N-ethylmaleimide sensitive), P09456 (PKA I regulatory subunit), P27881 (Hexokinase type II), P07872 (Acyl-coenzyme A oxidase), Q6DGF1 (Isocitrate dehydrogenase), Q9EQX9 (Ubiquitin-conjugating), Q63446 (Polyubiquitin), P24268 (Cathepsin D), Q91XW0 (Heat shock protein 86), Q5FVH0 (unknown), P58405 (Striatin 3), Q62667 (Major vault protein), Q66H50 (unknown), Q09167 (splicing factor), Q9JHU5 (Arfaptin 1)."|comment:"Insulin increased GLUT4 interaction with the following proteins:Q9Z1P2 (R-actinin-1), P45592 (Cofilin), Q9QXQ0 (R-actinin-4), P26473 (ADP-ribosylation factor), P26437 (ADP-ribosylation factor),   Q7TNP1 (Basigin 2), Q6P6R2 (Dihydrolipoamide dehydrogenase),   P04797 (GAPDH), Q63081 (Protein disulfide isomerase), P29457 (47 kDa heat shock protein), Q9R1J8 (Leprecan), O88638 (Putative eps protein),   Q64375 (Synaptonemal complex)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:NDPK - Interactions involving proteins containing InterPro domain IPR001564, Nucleoside diphosphate kinase, core.	taxid:10116(rat-l6)|taxid:10116(Rattus norvegicus)	-	2006/02/15	2021/11/30	rogid:PbFY2lfrty8yw40Jq7ShR7xfuV410116	rogid:SoYa3A+HfODn+V8i+Fgm7uFseow10116	intact-crc:44F3A2176D02515F|rigid:9RVm0UBcqQF4k06RGKO89Bg16Q8	false	myc tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P19357	uniprotkb:Q08163	intact:EBI-915426|uniprotkb:P97900|ensembl:ENSRNOP00000023256	intact:EBI-918234|uniprotkb:Q5FVS8|ensembl:ENSRNOP00000018711	psi-mi:glut4_rat(display_long)|uniprotkb:Glucose transporter type 4, insulin-responsive(gene name synonym)|uniprotkb:Slc2a4(gene name)|psi-mi:Slc2a4(display_short)|uniprotkb:Glut4(gene name synonym)	psi-mi:cap1_rat(display_long)|uniprotkb:Cap1(gene name)|psi-mi:Cap1(display_short)|uniprotkb:Cap(gene name synonym)|uniprotkb:Mch1(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Foster et al. (2006)	pubmed:16396496|mint:MINT-5218203	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-921030	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2711|refseq:NP_036883.1|refseq:XP_006246658.1|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007611"(learning or memory)|go:"GO:0007614"(short-term memory)|go:"GO:0007616"(long-term memory)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010021"(amylopectin biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031550"(positive regulation of brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044381"(glucose import in response to insulin stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046323"(glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0098694"(regulation of synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0098793"(presynapse)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002441("Glucose transporter, type 4 (GLUT4)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-189200|ensembl:ENSRNOG00000017226(gene)|ensembl:ENSRNOT00000023256(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)	rgd:620309|refseq:NP_071778.2|refseq:XP_006238892.1|refseq:XP_006238893.1|refseq:XP_006238894.1|dip:DIP-225N|ensembl:ENSRNOG00000013492(gene)|ensembl:ENSRNOT00000018711(transcript)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0001667"(ameboidal-type cell migration)|go:"GO:0003779"(actin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0008179"(adenylate cyclase binding)|go:"GO:0019933"(cAMP-mediated signaling)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030864"(cortical actin cytoskeleton)|go:"GO:0045761"(regulation of adenylate cyclase activity)|interpro:IPR001837(Adenylate cyclase-associated CAP)|interpro:IPR006599(CARP motif)|interpro:IPR013912(Adenylate cyclase-associated CAP,  C-terminal)|interpro:IPR013992(Adenylate cyclase-associated CAP, N-terminal)|interpro:IPR016098(Cyclase-associated protein CAP/septum formation inhibitor MinC, C-terminal)|interpro:IPR017901|interpro:IPR018106|interpro:IPR028415|interpro:IPR028417|interpro:IPR036222|interpro:IPR036223|reactome:R-RNO-6798695	-	-	-	caution:"The participant EBI-349571(P68370) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919386(Q7TP47) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920972(Q5XIP9) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-916419(P11980) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919578(Q8R491) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920554(Q5U3Z7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920647(Q5U2X8) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920585(Q7TP24) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-779677(P05426) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-915744(P02454) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|agonist:Insulin was shown to increase or decrease GLUT4 protein interactions in specific cases.|comment:"Insulin decreased GLUT4 interactions with the following proteins: Q9ER30 (Sarcosin), P09527 (Rab-7), O88960 (N-ethylmaleimide sensitive), P09456 (PKA I regulatory subunit), P27881 (Hexokinase type II), P07872 (Acyl-coenzyme A oxidase), Q6DGF1 (Isocitrate dehydrogenase), Q9EQX9 (Ubiquitin-conjugating), Q63446 (Polyubiquitin), P24268 (Cathepsin D), Q91XW0 (Heat shock protein 86), Q5FVH0 (unknown), P58405 (Striatin 3), Q62667 (Major vault protein), Q66H50 (unknown), Q09167 (splicing factor), Q9JHU5 (Arfaptin 1)."|comment:"Insulin increased GLUT4 interaction with the following proteins:Q9Z1P2 (R-actinin-1), P45592 (Cofilin), Q9QXQ0 (R-actinin-4), P26473 (ADP-ribosylation factor), P26437 (ADP-ribosylation factor),   Q7TNP1 (Basigin 2), Q6P6R2 (Dihydrolipoamide dehydrogenase),   P04797 (GAPDH), Q63081 (Protein disulfide isomerase), P29457 (47 kDa heat shock protein), Q9R1J8 (Leprecan), O88638 (Putative eps protein),   Q64375 (Synaptonemal complex)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:NDPK - Interactions involving proteins containing InterPro domain IPR001564, Nucleoside diphosphate kinase, core.	taxid:10116(rat-l6)|taxid:10116(Rattus norvegicus)	-	2006/02/15	2021/11/30	rogid:PbFY2lfrty8yw40Jq7ShR7xfuV410116	rogid:2mFV6WgWfM0TAfanYPuxwvWGbvE10116	intact-crc:44F3A2176D02515F|rigid:9RVm0UBcqQF4k06RGKO89Bg16Q8	false	myc tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P19357	uniprotkb:Q07984	intact:EBI-915426|uniprotkb:P97900|ensembl:ENSRNOP00000023256	intact:EBI-918227|ensembl:ENSRNOP00000070206	psi-mi:glut4_rat(display_long)|uniprotkb:Glucose transporter type 4, insulin-responsive(gene name synonym)|uniprotkb:Slc2a4(gene name)|psi-mi:Slc2a4(display_short)|uniprotkb:Glut4(gene name synonym)	psi-mi:ssrd_rat(display_long)|uniprotkb:Ssr4(gene name)|psi-mi:Ssr4(display_short)|uniprotkb:Signal sequence receptor subunit delta(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Foster et al. (2006)	pubmed:16396496|mint:MINT-5218203	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-921030	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2711|refseq:NP_036883.1|refseq:XP_006246658.1|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007611"(learning or memory)|go:"GO:0007614"(short-term memory)|go:"GO:0007616"(long-term memory)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010021"(amylopectin biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031550"(positive regulation of brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044381"(glucose import in response to insulin stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046323"(glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0098694"(regulation of synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0098793"(presynapse)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002441("Glucose transporter, type 4 (GLUT4)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-189200|ensembl:ENSRNOG00000017226(gene)|ensembl:ENSRNOT00000023256(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)	rgd:62034|refseq:NP_058895.1|ensembl:ENSRNOG00000053172(gene)|ensembl:ENSRNOT00000083557(transcript)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005784"(Sec61 translocon complex)|go:"GO:0012505"(endomembrane system)|go:"GO:0016021"(integral component of membrane)|interpro:IPR008855(Translocon-associated)	-	-	-	caution:"The participant EBI-349571(P68370) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919386(Q7TP47) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920972(Q5XIP9) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-916419(P11980) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919578(Q8R491) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920554(Q5U3Z7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920647(Q5U2X8) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920585(Q7TP24) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-779677(P05426) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-915744(P02454) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|agonist:Insulin was shown to increase or decrease GLUT4 protein interactions in specific cases.|comment:"Insulin decreased GLUT4 interactions with the following proteins: Q9ER30 (Sarcosin), P09527 (Rab-7), O88960 (N-ethylmaleimide sensitive), P09456 (PKA I regulatory subunit), P27881 (Hexokinase type II), P07872 (Acyl-coenzyme A oxidase), Q6DGF1 (Isocitrate dehydrogenase), Q9EQX9 (Ubiquitin-conjugating), Q63446 (Polyubiquitin), P24268 (Cathepsin D), Q91XW0 (Heat shock protein 86), Q5FVH0 (unknown), P58405 (Striatin 3), Q62667 (Major vault protein), Q66H50 (unknown), Q09167 (splicing factor), Q9JHU5 (Arfaptin 1)."|comment:"Insulin increased GLUT4 interaction with the following proteins:Q9Z1P2 (R-actinin-1), P45592 (Cofilin), Q9QXQ0 (R-actinin-4), P26473 (ADP-ribosylation factor), P26437 (ADP-ribosylation factor),   Q7TNP1 (Basigin 2), Q6P6R2 (Dihydrolipoamide dehydrogenase),   P04797 (GAPDH), Q63081 (Protein disulfide isomerase), P29457 (47 kDa heat shock protein), Q9R1J8 (Leprecan), O88638 (Putative eps protein),   Q64375 (Synaptonemal complex)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:NDPK - Interactions involving proteins containing InterPro domain IPR001564, Nucleoside diphosphate kinase, core.	taxid:10116(rat-l6)|taxid:10116(Rattus norvegicus)	-	2006/02/15	2021/11/30	rogid:PbFY2lfrty8yw40Jq7ShR7xfuV410116	rogid:u/ZYtKAViKJ4XAJV5j/6/qsL/ZI10116	intact-crc:44F3A2176D02515F|rigid:9RVm0UBcqQF4k06RGKO89Bg16Q8	false	myc tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P19357	uniprotkb:Q07936	intact:EBI-915426|uniprotkb:P97900|ensembl:ENSRNOP00000023256	intact:EBI-918209|ensembl:ENSRNOP00000038428	psi-mi:glut4_rat(display_long)|uniprotkb:Glucose transporter type 4, insulin-responsive(gene name synonym)|uniprotkb:Slc2a4(gene name)|psi-mi:Slc2a4(display_short)|uniprotkb:Glut4(gene name synonym)	psi-mi:anxa2_rat(display_long)|uniprotkb:Anxa2(gene name)|psi-mi:Anxa2(display_short)|uniprotkb:Anx2(gene name synonym)|uniprotkb:Annexin-2(gene name synonym)|uniprotkb:Annexin II(gene name synonym)|uniprotkb:Lipocortin II(gene name synonym)|uniprotkb:Calpactin I heavy chain(gene name synonym)|uniprotkb:Chromobindin-8(gene name synonym)|uniprotkb:p36(gene name synonym)|uniprotkb:Protein I(gene name synonym)|uniprotkb:Placental anticoagulant protein IV(gene name synonym)|uniprotkb:Calpactin-1 heavy chain(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Foster et al. (2006)	pubmed:16396496|mint:MINT-5218203	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-921030	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2711|refseq:NP_036883.1|refseq:XP_006246658.1|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007611"(learning or memory)|go:"GO:0007614"(short-term memory)|go:"GO:0007616"(long-term memory)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010021"(amylopectin biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031550"(positive regulation of brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044381"(glucose import in response to insulin stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046323"(glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0098694"(regulation of synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0098793"(presynapse)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002441("Glucose transporter, type 4 (GLUT4)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-189200|ensembl:ENSRNOG00000017226(gene)|ensembl:ENSRNOT00000023256(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)	rgd:621170|refseq:NP_063970.1|ensembl:ENSRNOG00000010362(gene)|ensembl:ENSRNOT00000038677(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001726"(ruffle)|go:"GO:0001765"(membrane raft assembly)|go:"GO:0001786"(phosphatidylserine binding)|go:"GO:0001921"(positive regulation of receptor recycling)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002020"(protease binding)|go:"GO:0004867"(serine-type endopeptidase inhibitor activity)|go:"GO:0005262"(calcium channel activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005544"(calcium-dependent phospholipid binding)|go:"GO:0005546"(phosphatidylinositol-4,5-bisphosphate binding)|go:"GO:0005604"(basement membrane)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005768"(endosome)|go:"GO:0005769"(early endosome)|go:"GO:0005811"(lipid droplet)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005938"(cell cortex)|go:"GO:0006900"(vesicle budding from membrane)|go:"GO:0007589"(body fluid secretion)|go:"GO:0009986"(cell surface)|go:"GO:0016020"(membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0019834"(phospholipase A2 inhibitor activity)|go:"GO:0019897"(extrinsic component of plasma membrane)|go:"GO:0030199"(collagen fibril organization)|go:"GO:0030496"(midbody)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031340"(positive regulation of vesicle fusion)|go:"GO:0031902"(late endosome membrane)|go:"GO:0031982"(vesicle)|go:"GO:0032804"(negative regulation of low-density lipoprotein particle receptor catabolic process)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035749"(myelin sheath adaxonal region)|go:"GO:0036035"(osteoclast development)|go:"GO:0042383"(sarcolemma)|go:"GO:0042470"(melanosome)|go:"GO:0042730"(fibrinolysis)|go:"GO:0042802"(identical protein binding)|go:"GO:0043220"(Schmidt-Lanterman incisure)|go:"GO:0044090"(positive regulation of vacuole organization)|go:"GO:0044147"(negative regulation of formation of structure involved in a symbiotic process)|go:"GO:0044354"(macropinosome)|go:"GO:0044548"(S100 protein binding)|go:"GO:0044730"(bone sialoprotein binding)|go:"GO:0045121"(membrane raft)|go:"GO:0046790"(virion binding)|go:"GO:0048146"(positive regulation of fibroblast proliferation)|go:"GO:0048306"(calcium-dependent protein binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051015"(actin filament binding)|go:"GO:0051099"(positive regulation of binding)|go:"GO:0051917"(regulation of fibrinolysis)|go:"GO:0052362"(obsolete catabolism by host of symbiont protein)|go:"GO:0052405"|go:"GO:0070062"(extracellular exosome)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0097066"(response to thyroid hormone)|go:"GO:1905581"(positive regulation of low-density lipoprotein particle clearance)|go:"GO:1905597"(positive regulation of low-density lipoprotein particle receptor binding)|go:"GO:1905599"(positive regulation of low-density lipoprotein receptor activity)|go:"GO:1905602"(positive regulation of receptor-mediated endocytosis involved in cholesterol transport)|go:"GO:1990665"(AnxA2-p11 complex)|go:"GO:1990667"(PCSK9-AnxA2 complex)|interpro:IPR001464(Annexin)|interpro:IPR002389(Annexin, type II)|interpro:IPR018252|interpro:IPR018502|interpro:IPR037104|reactome:R-RNO-6798695|reactome:R-RNO-75205	-	-	-	caution:"The participant EBI-349571(P68370) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919386(Q7TP47) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920972(Q5XIP9) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-916419(P11980) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919578(Q8R491) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920554(Q5U3Z7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920647(Q5U2X8) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920585(Q7TP24) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-779677(P05426) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-915744(P02454) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|agonist:Insulin was shown to increase or decrease GLUT4 protein interactions in specific cases.|comment:"Insulin decreased GLUT4 interactions with the following proteins: Q9ER30 (Sarcosin), P09527 (Rab-7), O88960 (N-ethylmaleimide sensitive), P09456 (PKA I regulatory subunit), P27881 (Hexokinase type II), P07872 (Acyl-coenzyme A oxidase), Q6DGF1 (Isocitrate dehydrogenase), Q9EQX9 (Ubiquitin-conjugating), Q63446 (Polyubiquitin), P24268 (Cathepsin D), Q91XW0 (Heat shock protein 86), Q5FVH0 (unknown), P58405 (Striatin 3), Q62667 (Major vault protein), Q66H50 (unknown), Q09167 (splicing factor), Q9JHU5 (Arfaptin 1)."|comment:"Insulin increased GLUT4 interaction with the following proteins:Q9Z1P2 (R-actinin-1), P45592 (Cofilin), Q9QXQ0 (R-actinin-4), P26473 (ADP-ribosylation factor), P26437 (ADP-ribosylation factor),   Q7TNP1 (Basigin 2), Q6P6R2 (Dihydrolipoamide dehydrogenase),   P04797 (GAPDH), Q63081 (Protein disulfide isomerase), P29457 (47 kDa heat shock protein), Q9R1J8 (Leprecan), O88638 (Putative eps protein),   Q64375 (Synaptonemal complex)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:NDPK - Interactions involving proteins containing InterPro domain IPR001564, Nucleoside diphosphate kinase, core.	taxid:10116(rat-l6)|taxid:10116(Rattus norvegicus)	-	2006/02/15	2021/11/30	rogid:PbFY2lfrty8yw40Jq7ShR7xfuV410116	rogid:SOUcyxKVc0YRMNALClXoYKomQT810116	intact-crc:44F3A2176D02515F|rigid:9RVm0UBcqQF4k06RGKO89Bg16Q8	false	myc tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P19357	uniprotkb:Q07266	intact:EBI-915426|uniprotkb:P97900|ensembl:ENSRNOP00000023256	intact:EBI-918187|uniprotkb:A5D6R1|uniprotkb:O70205	psi-mi:glut4_rat(display_long)|uniprotkb:Glucose transporter type 4, insulin-responsive(gene name synonym)|uniprotkb:Slc2a4(gene name)|psi-mi:Slc2a4(display_short)|uniprotkb:Glut4(gene name synonym)	psi-mi:dreb_rat(display_long)|uniprotkb:Dbn1(gene name)|psi-mi:Dbn1(display_short)|uniprotkb:Developmentally-regulated brain protein(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Foster et al. (2006)	pubmed:16396496|mint:MINT-5218203	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-921030	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2711|refseq:NP_036883.1|refseq:XP_006246658.1|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007611"(learning or memory)|go:"GO:0007614"(short-term memory)|go:"GO:0007616"(long-term memory)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010021"(amylopectin biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031550"(positive regulation of brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044381"(glucose import in response to insulin stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046323"(glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0098694"(regulation of synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0098793"(presynapse)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002441("Glucose transporter, type 4 (GLUT4)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-189200|ensembl:ENSRNOG00000017226(gene)|ensembl:ENSRNOT00000023256(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)	rgd:70885|refseq:NP_112286.1|interpro:IPR002108(Actin-binding, cofilin/tropomyosin type)|interpro:IPR028438|mint:Q07266|interpro:IPR029006|refseq:XP_006253719.1|go:"GO:0001701"(in utero embryonic development)|go:"GO:0005522"(profilin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005921"(gap junction)|go:"GO:0007015"(actin filament organization)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007399"(nervous system development)|go:"GO:0007420"(brain development)|go:"GO:0007568"(aging)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0010643"(cell communication by chemical coupling)|go:"GO:0010644"(cell communication by electrical coupling)|go:"GO:0010811"(positive regulation of cell-substrate adhesion)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0014823"(response to activity)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0030027"(lamellipodium)|go:"GO:0030175"(filopodium)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0030427"(site of polarized growth)|go:"GO:0030833"(regulation of actin filament polymerization)|go:"GO:0030864"(cortical actin cytoskeleton)|go:"GO:0031915"(positive regulation of synaptic plasticity)|go:"GO:0032232"(negative regulation of actin filament bundle assembly)|go:"GO:0032279"(asymmetric synapse)|go:"GO:0032507"(maintenance of protein location in cell)|go:"GO:0042493"|go:"GO:0043025"(neuronal cell body)|go:"GO:0043197"(dendritic spine)|go:"GO:0043198"(dendritic shaft)|go:"GO:0044295"(axonal growth cone)|go:"GO:0044308"(axonal spine)|go:"GO:0044309"(neuron spine)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045773"(positive regulation of axon extension)|go:"GO:0048286"(lung alveolus development)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048699"(generation of neurons)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0051015"(actin filament binding)|go:"GO:0051220"(cytoplasmic sequestering of protein)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0060076"(excitatory synapse)|go:"GO:0060134"(prepulse inhibition)|go:"GO:0061003"(positive regulation of dendritic spine morphogenesis)|go:"GO:0061351"(neural precursor cell proliferation)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071481"(cellular response to X-ray)|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|go:"GO:0090327"(negative regulation of locomotion involved in locomotory behavior)|go:"GO:0098828"(modulation of inhibitory postsynaptic potential)|go:"GO:0098871"(postsynaptic actin cytoskeleton)|go:"GO:0098974"(postsynaptic actin cytoskeleton organization)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:0120080"(obsolete negative regulation of microfilament motor activity)|go:"GO:1900026"(positive regulation of substrate adhesion-dependent cell spreading)|go:"GO:1902685"(positive regulation of receptor localization to synapse)|go:"GO:1902737"(dendritic filopodium)|go:"GO:1902897"(regulation of postsynaptic density protein 95 clustering)|go:"GO:1904113"(negative regulation of muscle filament sliding)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|reactome:R-RNO-9013405|reactome:R-RNO-9013407|reactome:R-RNO-9013418|reactome:R-RNO-9013422	-	-	-	caution:"The participant EBI-349571(P68370) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919386(Q7TP47) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920972(Q5XIP9) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-916419(P11980) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919578(Q8R491) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920554(Q5U3Z7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920647(Q5U2X8) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920585(Q7TP24) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-779677(P05426) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-915744(P02454) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|agonist:Insulin was shown to increase or decrease GLUT4 protein interactions in specific cases.|comment:"Insulin decreased GLUT4 interactions with the following proteins: Q9ER30 (Sarcosin), P09527 (Rab-7), O88960 (N-ethylmaleimide sensitive), P09456 (PKA I regulatory subunit), P27881 (Hexokinase type II), P07872 (Acyl-coenzyme A oxidase), Q6DGF1 (Isocitrate dehydrogenase), Q9EQX9 (Ubiquitin-conjugating), Q63446 (Polyubiquitin), P24268 (Cathepsin D), Q91XW0 (Heat shock protein 86), Q5FVH0 (unknown), P58405 (Striatin 3), Q62667 (Major vault protein), Q66H50 (unknown), Q09167 (splicing factor), Q9JHU5 (Arfaptin 1)."|comment:"Insulin increased GLUT4 interaction with the following proteins:Q9Z1P2 (R-actinin-1), P45592 (Cofilin), Q9QXQ0 (R-actinin-4), P26473 (ADP-ribosylation factor), P26437 (ADP-ribosylation factor),   Q7TNP1 (Basigin 2), Q6P6R2 (Dihydrolipoamide dehydrogenase),   P04797 (GAPDH), Q63081 (Protein disulfide isomerase), P29457 (47 kDa heat shock protein), Q9R1J8 (Leprecan), O88638 (Putative eps protein),   Q64375 (Synaptonemal complex)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:NDPK - Interactions involving proteins containing InterPro domain IPR001564, Nucleoside diphosphate kinase, core.	taxid:10116(rat-l6)|taxid:10116(Rattus norvegicus)	-	2006/02/15	2021/11/30	rogid:PbFY2lfrty8yw40Jq7ShR7xfuV410116	rogid:ywce7jMZtfDwzFWvAURT5bUsmdY10116	intact-crc:44F3A2176D02515F|rigid:9RVm0UBcqQF4k06RGKO89Bg16Q8	false	myc tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P19357	uniprotkb:Q06647	intact:EBI-915426|uniprotkb:P97900|ensembl:ENSRNOP00000023256	intact:EBI-918179|ensembl:ENSRNOP00000002732	psi-mi:glut4_rat(display_long)|uniprotkb:Glucose transporter type 4, insulin-responsive(gene name synonym)|uniprotkb:Slc2a4(gene name)|psi-mi:Slc2a4(display_short)|uniprotkb:Glut4(gene name synonym)	psi-mi:atpo_rat(display_long)|uniprotkb:Atp5po(gene name)|psi-mi:Atp5po(display_short)|uniprotkb:ATP synthase peripheral stalk subunit OSCP(gene name synonym)|uniprotkb:Atp5o(gene name synonym)|uniprotkb:Oligomycin sensitivity conferral protein(gene name synonym)|uniprotkb:Sperm flagella protein 4(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Foster et al. (2006)	pubmed:16396496|mint:MINT-5218203	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-921030	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2711|refseq:NP_036883.1|refseq:XP_006246658.1|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007611"(learning or memory)|go:"GO:0007614"(short-term memory)|go:"GO:0007616"(long-term memory)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010021"(amylopectin biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031550"(positive regulation of brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044381"(glucose import in response to insulin stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046323"(glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0098694"(regulation of synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0098793"(presynapse)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002441("Glucose transporter, type 4 (GLUT4)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-189200|ensembl:ENSRNOG00000017226(gene)|ensembl:ENSRNOT00000023256(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)	rgd:621379|refseq:NP_620238.1|ensembl:ENSRNOG00000001991(gene)|ensembl:ENSRNOT00000002732(transcript)|go:"GO:0000274"(mitochondrial proton-transporting ATP synthase, stator stalk)|go:"GO:0000276"("mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)")|go:"GO:0005739"(mitochondrion)|go:"GO:0005753"(mitochondrial proton-transporting ATP synthase complex)|go:"GO:0005886"(plasma membrane)|go:"GO:0006754"(ATP biosynthetic process)|go:"GO:0009986"(cell surface)|go:"GO:0015986"(ATP synthesis coupled proton transport)|go:"GO:0042776"(mitochondrial ATP synthesis coupled proton transport)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045261"("proton-transporting ATP synthase complex, catalytic core F(1)")|go:"GO:0046034"(ATP metabolic process)|go:"GO:0046933"(proton-transporting ATP synthase activity, rotational mechanism)|go:"GO:0071320"(cellular response to cAMP)|go:"GO:0071345"(cellular response to cytokine stimulus)|go:"GO:1903924"(estradiol binding)|interpro:IPR000711(ATPase, F1 complex, OSCP/delta subunit)|interpro:IPR020781|interpro:IPR026015|mint:Q06647|reactome:R-RNO-163210|reactome:R-RNO-8949613	-	-	-	caution:"The participant EBI-349571(P68370) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919386(Q7TP47) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920972(Q5XIP9) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-916419(P11980) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919578(Q8R491) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920554(Q5U3Z7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920647(Q5U2X8) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920585(Q7TP24) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-779677(P05426) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-915744(P02454) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|agonist:Insulin was shown to increase or decrease GLUT4 protein interactions in specific cases.|comment:"Insulin decreased GLUT4 interactions with the following proteins: Q9ER30 (Sarcosin), P09527 (Rab-7), O88960 (N-ethylmaleimide sensitive), P09456 (PKA I regulatory subunit), P27881 (Hexokinase type II), P07872 (Acyl-coenzyme A oxidase), Q6DGF1 (Isocitrate dehydrogenase), Q9EQX9 (Ubiquitin-conjugating), Q63446 (Polyubiquitin), P24268 (Cathepsin D), Q91XW0 (Heat shock protein 86), Q5FVH0 (unknown), P58405 (Striatin 3), Q62667 (Major vault protein), Q66H50 (unknown), Q09167 (splicing factor), Q9JHU5 (Arfaptin 1)."|comment:"Insulin increased GLUT4 interaction with the following proteins:Q9Z1P2 (R-actinin-1), P45592 (Cofilin), Q9QXQ0 (R-actinin-4), P26473 (ADP-ribosylation factor), P26437 (ADP-ribosylation factor),   Q7TNP1 (Basigin 2), Q6P6R2 (Dihydrolipoamide dehydrogenase),   P04797 (GAPDH), Q63081 (Protein disulfide isomerase), P29457 (47 kDa heat shock protein), Q9R1J8 (Leprecan), O88638 (Putative eps protein),   Q64375 (Synaptonemal complex)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:NDPK - Interactions involving proteins containing InterPro domain IPR001564, Nucleoside diphosphate kinase, core.	taxid:10116(rat-l6)|taxid:10116(Rattus norvegicus)	-	2006/02/15	2021/11/30	rogid:PbFY2lfrty8yw40Jq7ShR7xfuV410116	rogid:F/PihaxUf1uclL8LOwKpSse+dCA10116	intact-crc:44F3A2176D02515F|rigid:9RVm0UBcqQF4k06RGKO89Bg16Q8	false	myc tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P19357	uniprotkb:Q05962	intact:EBI-915426|uniprotkb:P97900|ensembl:ENSRNOP00000023256	intact:EBI-918169	psi-mi:glut4_rat(display_long)|uniprotkb:Glucose transporter type 4, insulin-responsive(gene name synonym)|uniprotkb:Slc2a4(gene name)|psi-mi:Slc2a4(display_short)|uniprotkb:Glut4(gene name synonym)	psi-mi:adt1_rat(display_long)|uniprotkb:Adenine nucleotide translocator 1(gene name synonym)|uniprotkb:ADP,ATP carrier protein 1(gene name synonym)|uniprotkb:Solute carrier family 25 member 4(gene name synonym)|uniprotkb:Slc25a4(gene name)|psi-mi:Slc25a4(display_short)|uniprotkb:Ant1(gene name synonym)|uniprotkb:Aac1(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Foster et al. (2006)	pubmed:16396496|mint:MINT-5218203	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-921030	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2711|refseq:NP_036883.1|refseq:XP_006246658.1|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007611"(learning or memory)|go:"GO:0007614"(short-term memory)|go:"GO:0007616"(long-term memory)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010021"(amylopectin biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031550"(positive regulation of brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044381"(glucose import in response to insulin stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046323"(glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0098694"(regulation of synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0098793"(presynapse)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002441("Glucose transporter, type 4 (GLUT4)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-189200|ensembl:ENSRNOG00000017226(gene)|ensembl:ENSRNOT00000023256(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)	rgd:620352|refseq:NP_445967.1|interpro:IPR002113(Adenine nucleotide translocator 1)|interpro:IPR002067(Mitochondrial carrier protein)|interpro:IPR018108|interpro:IPR023395|mint:Q05962|go:"GO:0001889"(liver development)|go:"GO:0005471"("ATP:ADP antiporter activity")|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005757"(mitochondrial permeability transition pore complex)|go:"GO:0007507"(heart development)|go:"GO:0007568"(aging)|go:"GO:0008637"(apoptotic mitochondrial changes)|go:"GO:0010667"(negative regulation of cardiac muscle cell apoptotic process)|go:"GO:0015078"(proton transmembrane transporter activity)|go:"GO:0015866"(ADP transport)|go:"GO:0016020"(membrane)|go:"GO:0017077"(oxidative phosphorylation uncoupler activity)|go:"GO:0019899"(enzyme binding)|go:"GO:0032592"(integral component of mitochondrial membrane)|go:"GO:0045121"(membrane raft)|go:"GO:0046902"(regulation of mitochondrial membrane permeability)|go:"GO:0060546"(negative regulation of necroptotic process)|go:"GO:0061051"(positive regulation of cell growth involved in cardiac muscle cell development)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0140021"(mitochondrial ADP transmembrane transport)|go:"GO:1901526"(positive regulation of mitophagy)|go:"GO:1902109"(negative regulation of mitochondrial membrane permeability involved in apoptotic process)|go:"GO:1990544"(mitochondrial ATP transmembrane transport)|go:"GO:1990845"(adaptive thermogenesis)|go:"GO:2000277"(positive regulation of oxidative phosphorylation uncoupler activity)|reactome:R-RNO-83936	-	-	-	caution:"The participant EBI-349571(P68370) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919386(Q7TP47) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920972(Q5XIP9) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-916419(P11980) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919578(Q8R491) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920554(Q5U3Z7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920647(Q5U2X8) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920585(Q7TP24) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-779677(P05426) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-915744(P02454) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|agonist:Insulin was shown to increase or decrease GLUT4 protein interactions in specific cases.|comment:"Insulin decreased GLUT4 interactions with the following proteins: Q9ER30 (Sarcosin), P09527 (Rab-7), O88960 (N-ethylmaleimide sensitive), P09456 (PKA I regulatory subunit), P27881 (Hexokinase type II), P07872 (Acyl-coenzyme A oxidase), Q6DGF1 (Isocitrate dehydrogenase), Q9EQX9 (Ubiquitin-conjugating), Q63446 (Polyubiquitin), P24268 (Cathepsin D), Q91XW0 (Heat shock protein 86), Q5FVH0 (unknown), P58405 (Striatin 3), Q62667 (Major vault protein), Q66H50 (unknown), Q09167 (splicing factor), Q9JHU5 (Arfaptin 1)."|comment:"Insulin increased GLUT4 interaction with the following proteins:Q9Z1P2 (R-actinin-1), P45592 (Cofilin), Q9QXQ0 (R-actinin-4), P26473 (ADP-ribosylation factor), P26437 (ADP-ribosylation factor),   Q7TNP1 (Basigin 2), Q6P6R2 (Dihydrolipoamide dehydrogenase),   P04797 (GAPDH), Q63081 (Protein disulfide isomerase), P29457 (47 kDa heat shock protein), Q9R1J8 (Leprecan), O88638 (Putative eps protein),   Q64375 (Synaptonemal complex)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:NDPK - Interactions involving proteins containing InterPro domain IPR001564, Nucleoside diphosphate kinase, core.	taxid:10116(rat-l6)|taxid:10116(Rattus norvegicus)	-	2006/02/15	2021/11/30	rogid:PbFY2lfrty8yw40Jq7ShR7xfuV410116	rogid:NA6aO99oqoOE7rPf9y3s7zKx6HM10116	intact-crc:44F3A2176D02515F|rigid:9RVm0UBcqQF4k06RGKO89Bg16Q8	false	myc tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P19357	uniprotkb:Q04462	intact:EBI-915426|uniprotkb:P97900|ensembl:ENSRNOP00000023256	intact:EBI-918152|uniprotkb:Q6MG65|ensembl:ENSRNOP00000001160|ensembl:ENSRNOP00000072696	psi-mi:glut4_rat(display_long)|uniprotkb:Glucose transporter type 4, insulin-responsive(gene name synonym)|uniprotkb:Slc2a4(gene name)|psi-mi:Slc2a4(display_short)|uniprotkb:Glut4(gene name synonym)	psi-mi:syvc_rat(display_long)|uniprotkb:Vars1(gene name)|psi-mi:Vars1(display_short)|uniprotkb:Valyl-tRNA synthetase(gene name synonym)|uniprotkb:Vars(gene name synonym)|uniprotkb:Vars2(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Foster et al. (2006)	pubmed:16396496|mint:MINT-5218203	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-921030	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2711|refseq:NP_036883.1|refseq:XP_006246658.1|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007611"(learning or memory)|go:"GO:0007614"(short-term memory)|go:"GO:0007616"(long-term memory)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010021"(amylopectin biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031550"(positive regulation of brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044381"(glucose import in response to insulin stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046323"(glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0098694"(regulation of synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0098793"(presynapse)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002441("Glucose transporter, type 4 (GLUT4)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-189200|ensembl:ENSRNOG00000017226(gene)|ensembl:ENSRNOT00000023256(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)	rgd:3950|refseq:NP_445744.1|refseq:XP_006256109.1|ensembl:ENSRNOG00000000867(gene)|ensembl:ENSRNOT00000001160(transcript)|ensembl:ENSRNOT00000087861(transcript)|go:"GO:0002161"(aminoacyl-tRNA editing activity)|go:"GO:0004832"(valine-tRNA ligase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005829"(cytosol)|go:"GO:0006438"(valyl-tRNA aminoacylation)|interpro:IPR001412(Aminoacyl-tRNA synthetase, class I, conserved site)|interpro:IPR002300(Aminoacyl-tRNA synthetase, class Ia)|interpro:IPR002303(Valyl-tRNA synthetase, class Ia)|interpro:IPR004046(Glutathione S-transferase, C-terminal)|interpro:IPR009008(Valyl/Leucyl/Isoleucyl-tRNA synthetase, class Ia, editing)|interpro:IPR009080(Aminoacyl-tRNA synthetase, class 1a, anticodon-binding)|interpro:IPR010987(Glutathione S-transferase, C-terminal-like)|interpro:IPR013155(Valyl/Leucyl/Isoleucyl-tRNA synthetase, class I, anticodon-binding)|interpro:IPR014729(Rossmann-like alpha/beta/alpha sandwich fold)|interpro:IPR033705|interpro:IPR036282|interpro:IPR037118|mint:Q04462	-	-	-	caution:"The participant EBI-349571(P68370) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919386(Q7TP47) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920972(Q5XIP9) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-916419(P11980) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919578(Q8R491) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920554(Q5U3Z7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920647(Q5U2X8) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920585(Q7TP24) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-779677(P05426) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-915744(P02454) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|agonist:Insulin was shown to increase or decrease GLUT4 protein interactions in specific cases.|comment:"Insulin decreased GLUT4 interactions with the following proteins: Q9ER30 (Sarcosin), P09527 (Rab-7), O88960 (N-ethylmaleimide sensitive), P09456 (PKA I regulatory subunit), P27881 (Hexokinase type II), P07872 (Acyl-coenzyme A oxidase), Q6DGF1 (Isocitrate dehydrogenase), Q9EQX9 (Ubiquitin-conjugating), Q63446 (Polyubiquitin), P24268 (Cathepsin D), Q91XW0 (Heat shock protein 86), Q5FVH0 (unknown), P58405 (Striatin 3), Q62667 (Major vault protein), Q66H50 (unknown), Q09167 (splicing factor), Q9JHU5 (Arfaptin 1)."|comment:"Insulin increased GLUT4 interaction with the following proteins:Q9Z1P2 (R-actinin-1), P45592 (Cofilin), Q9QXQ0 (R-actinin-4), P26473 (ADP-ribosylation factor), P26437 (ADP-ribosylation factor),   Q7TNP1 (Basigin 2), Q6P6R2 (Dihydrolipoamide dehydrogenase),   P04797 (GAPDH), Q63081 (Protein disulfide isomerase), P29457 (47 kDa heat shock protein), Q9R1J8 (Leprecan), O88638 (Putative eps protein),   Q64375 (Synaptonemal complex)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:NDPK - Interactions involving proteins containing InterPro domain IPR001564, Nucleoside diphosphate kinase, core.	taxid:10116(rat-l6)|taxid:10116(Rattus norvegicus)	-	2006/02/15	2021/11/30	rogid:PbFY2lfrty8yw40Jq7ShR7xfuV410116	rogid:MfDvMeOqEJmQ91kfIi2hfNZM1Bk10116	intact-crc:44F3A2176D02515F|rigid:9RVm0UBcqQF4k06RGKO89Bg16Q8	false	myc tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P19357	uniprotkb:Q02253	intact:EBI-915426|uniprotkb:P97900|ensembl:ENSRNOP00000023256	intact:EBI-918138	psi-mi:glut4_rat(display_long)|uniprotkb:Glucose transporter type 4, insulin-responsive(gene name synonym)|uniprotkb:Slc2a4(gene name)|psi-mi:Slc2a4(display_short)|uniprotkb:Glut4(gene name synonym)	psi-mi:mmsa_rat(display_long)|uniprotkb:Aldehyde dehydrogenase family 6 member A1(gene name synonym)|uniprotkb:Aldh6a1(gene name)|psi-mi:Aldh6a1(display_short)|uniprotkb:Mmsdh(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Foster et al. (2006)	pubmed:16396496|mint:MINT-5218203	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-921030	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2711|refseq:NP_036883.1|refseq:XP_006246658.1|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007611"(learning or memory)|go:"GO:0007614"(short-term memory)|go:"GO:0007616"(long-term memory)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010021"(amylopectin biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031550"(positive regulation of brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044381"(glucose import in response to insulin stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046323"(glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0098694"(regulation of synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0098793"(presynapse)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002441("Glucose transporter, type 4 (GLUT4)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-189200|ensembl:ENSRNOG00000017226(gene)|ensembl:ENSRNOT00000023256(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)	rgd:621556|refseq:NP_112319.2|interpro:IPR016161(Aldehyde/histidinol dehydrogenase)|interpro:IPR016160(Aldehyde dehydrogenase, conserved site)|interpro:IPR016162(Aldehyde dehydrogenase, N-terminal)|interpro:IPR015590(Aldehyde dehydrogenase)|interpro:IPR010061(Methylmalonate-semialdehyde dehydrogenase)|interpro:IPR016163(Aldehyde dehydrogenase, C-terminal)|reactome:R-RNO-70895|go:"GO:0000062"(fatty-acyl-CoA binding)|go:"GO:0004491"("methylmalonate-semialdehyde dehydrogenase (acylating) activity")|go:"GO:0005739"(mitochondrion)|go:"GO:0006210"(thymine catabolic process)|go:"GO:0006573"(valine metabolic process)|go:"GO:0006574"(valine catabolic process)|go:"GO:0016790"(thiolester hydrolase activity)|go:"GO:0018478"("malonate-semialdehyde dehydrogenase (acetylating) activity")|go:"GO:0019484"(beta-alanine catabolic process)|go:"GO:0019859"(thymine metabolic process)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0102662"("malonate-semialdehyde dehydrogenase (acetylating, NAD+) activity")	-	-	-	caution:"The participant EBI-349571(P68370) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919386(Q7TP47) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920972(Q5XIP9) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-916419(P11980) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919578(Q8R491) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920554(Q5U3Z7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920647(Q5U2X8) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920585(Q7TP24) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-779677(P05426) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-915744(P02454) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|agonist:Insulin was shown to increase or decrease GLUT4 protein interactions in specific cases.|comment:"Insulin decreased GLUT4 interactions with the following proteins: Q9ER30 (Sarcosin), P09527 (Rab-7), O88960 (N-ethylmaleimide sensitive), P09456 (PKA I regulatory subunit), P27881 (Hexokinase type II), P07872 (Acyl-coenzyme A oxidase), Q6DGF1 (Isocitrate dehydrogenase), Q9EQX9 (Ubiquitin-conjugating), Q63446 (Polyubiquitin), P24268 (Cathepsin D), Q91XW0 (Heat shock protein 86), Q5FVH0 (unknown), P58405 (Striatin 3), Q62667 (Major vault protein), Q66H50 (unknown), Q09167 (splicing factor), Q9JHU5 (Arfaptin 1)."|comment:"Insulin increased GLUT4 interaction with the following proteins:Q9Z1P2 (R-actinin-1), P45592 (Cofilin), Q9QXQ0 (R-actinin-4), P26473 (ADP-ribosylation factor), P26437 (ADP-ribosylation factor),   Q7TNP1 (Basigin 2), Q6P6R2 (Dihydrolipoamide dehydrogenase),   P04797 (GAPDH), Q63081 (Protein disulfide isomerase), P29457 (47 kDa heat shock protein), Q9R1J8 (Leprecan), O88638 (Putative eps protein),   Q64375 (Synaptonemal complex)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:NDPK - Interactions involving proteins containing InterPro domain IPR001564, Nucleoside diphosphate kinase, core.	taxid:10116(rat-l6)|taxid:10116(Rattus norvegicus)	-	2006/02/15	2021/11/30	rogid:PbFY2lfrty8yw40Jq7ShR7xfuV410116	rogid:pg7JVphz4X3DMq8Kocjr4uU69u810116	intact-crc:44F3A2176D02515F|rigid:9RVm0UBcqQF4k06RGKO89Bg16Q8	false	myc tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P19357	uniprotkb:Q01205	intact:EBI-915426|uniprotkb:P97900|ensembl:ENSRNOP00000023256	intact:EBI-918128|uniprotkb:Q5XI35	psi-mi:glut4_rat(display_long)|uniprotkb:Glucose transporter type 4, insulin-responsive(gene name synonym)|uniprotkb:Slc2a4(gene name)|psi-mi:Slc2a4(display_short)|uniprotkb:Glut4(gene name synonym)	psi-mi:odo2_rat(display_long)|uniprotkb:Dihydrolipoamide succinyltransferase component of 2-oxoglutarate dehydrogenase complex(gene name synonym)|uniprotkb:E2K(gene name synonym)|uniprotkb:Dlst(gene name)|psi-mi:Dlst(display_short)|uniprotkb:2-oxoglutarate dehydrogenase complex component E2(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Foster et al. (2006)	pubmed:16396496|mint:MINT-5218203	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-921030	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2711|refseq:NP_036883.1|refseq:XP_006246658.1|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007611"(learning or memory)|go:"GO:0007614"(short-term memory)|go:"GO:0007616"(long-term memory)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010021"(amylopectin biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031550"(positive regulation of brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044381"(glucose import in response to insulin stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046323"(glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0098694"(regulation of synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0098793"(presynapse)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002441("Glucose transporter, type 4 (GLUT4)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-189200|ensembl:ENSRNOG00000017226(gene)|ensembl:ENSRNOT00000023256(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)	mint:Q01205|rgd:1359615|refseq:NP_001006982.2|interpro:IPR003016(2-oxo acid dehydrogenase, lipoyl-binding site)|interpro:IPR001078(Catalytic domain of components of various dehydrogenase complexes)|interpro:IPR000089(Biotin/lipoyl attachment)|interpro:IPR011053(Single hybrid motif)|interpro:IPR006255(Dihydrolipoamide succinyltransferase)|interpro:IPR023213|go:"GO:0004149"(dihydrolipoyllysine-residue succinyltransferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005886"(plasma membrane)|go:"GO:0006099"(tricarboxylic acid cycle)|go:"GO:0006103"(2-oxoglutarate metabolic process)|go:"GO:0006104"(succinyl-CoA metabolic process)|go:"GO:0006734"(NADH metabolic process)|go:"GO:0016746"(acyltransferase activity)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0033512"(L-lysine catabolic process to acetyl-CoA via saccharopine)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045252"(oxoglutarate dehydrogenase complex)|go:"GO:0051087"(chaperone binding)|go:"GO:0106077"(histone succinylation)|reactome:R-RNO-389661|reactome:R-RNO-71064|reactome:R-RNO-71403	-	-	-	caution:"The participant EBI-349571(P68370) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919386(Q7TP47) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920972(Q5XIP9) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-916419(P11980) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919578(Q8R491) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920554(Q5U3Z7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920647(Q5U2X8) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920585(Q7TP24) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-779677(P05426) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-915744(P02454) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|agonist:Insulin was shown to increase or decrease GLUT4 protein interactions in specific cases.|comment:"Insulin decreased GLUT4 interactions with the following proteins: Q9ER30 (Sarcosin), P09527 (Rab-7), O88960 (N-ethylmaleimide sensitive), P09456 (PKA I regulatory subunit), P27881 (Hexokinase type II), P07872 (Acyl-coenzyme A oxidase), Q6DGF1 (Isocitrate dehydrogenase), Q9EQX9 (Ubiquitin-conjugating), Q63446 (Polyubiquitin), P24268 (Cathepsin D), Q91XW0 (Heat shock protein 86), Q5FVH0 (unknown), P58405 (Striatin 3), Q62667 (Major vault protein), Q66H50 (unknown), Q09167 (splicing factor), Q9JHU5 (Arfaptin 1)."|comment:"Insulin increased GLUT4 interaction with the following proteins:Q9Z1P2 (R-actinin-1), P45592 (Cofilin), Q9QXQ0 (R-actinin-4), P26473 (ADP-ribosylation factor), P26437 (ADP-ribosylation factor),   Q7TNP1 (Basigin 2), Q6P6R2 (Dihydrolipoamide dehydrogenase),   P04797 (GAPDH), Q63081 (Protein disulfide isomerase), P29457 (47 kDa heat shock protein), Q9R1J8 (Leprecan), O88638 (Putative eps protein),   Q64375 (Synaptonemal complex)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:NDPK - Interactions involving proteins containing InterPro domain IPR001564, Nucleoside diphosphate kinase, core.	taxid:10116(rat-l6)|taxid:10116(Rattus norvegicus)	-	2006/02/15	2021/11/30	rogid:PbFY2lfrty8yw40Jq7ShR7xfuV410116	rogid:Ytjw7Tvj7aVaGmQksyMIBlweGUk10116	intact-crc:44F3A2176D02515F|rigid:9RVm0UBcqQF4k06RGKO89Bg16Q8	false	myc tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P19357	uniprotkb:Q00972	intact:EBI-915426|uniprotkb:P97900|ensembl:ENSRNOP00000023256	intact:EBI-593839|uniprotkb:Q64552|ensembl:ENSRNOP00000069014	psi-mi:glut4_rat(display_long)|uniprotkb:Glucose transporter type 4, insulin-responsive(gene name synonym)|uniprotkb:Slc2a4(gene name)|psi-mi:Slc2a4(display_short)|uniprotkb:Glut4(gene name synonym)	psi-mi:bckd_rat(display_long)|uniprotkb:Branched-chain alpha-ketoacid dehydrogenase kinase(gene name synonym)|uniprotkb:Bckdk(gene name)|psi-mi:Bckdk(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Foster et al. (2006)	pubmed:16396496|mint:MINT-5218203	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-921030	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2711|refseq:NP_036883.1|refseq:XP_006246658.1|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007611"(learning or memory)|go:"GO:0007614"(short-term memory)|go:"GO:0007616"(long-term memory)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010021"(amylopectin biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031550"(positive regulation of brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044381"(glucose import in response to insulin stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046323"(glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0098694"(regulation of synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0098793"(presynapse)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002441("Glucose transporter, type 4 (GLUT4)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-189200|ensembl:ENSRNOG00000017226(gene)|ensembl:ENSRNOT00000023256(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)	rgd:2198|refseq:NP_062117.2|ensembl:ENSRNOG00000019485(gene)|ensembl:ENSRNOT00000078578(transcript)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004740"("pyruvate dehydrogenase (acetyl-transferring) kinase activity")|go:"GO:0005524"(ATP binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005947"(mitochondrial alpha-ketoglutarate dehydrogenase complex)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006550"(isoleucine catabolic process)|go:"GO:0006552"(leucine catabolic process)|go:"GO:0006574"(valine catabolic process)|go:"GO:0007283"(spermatogenesis)|go:"GO:0009083"(branched-chain amino acid catabolic process)|go:"GO:0010906"(regulation of glucose metabolic process)|go:"GO:0016310"(phosphorylation)|go:"GO:0047323"("[3-methyl-2-oxobutanoate dehydrogenase (acetyl-transferring)] kinase activity")|interpro:IPR003594(ATP-binding region, ATPase-like)|interpro:IPR004358(Signal transduction histidine kinase-related protein, C-terminal)|interpro:IPR005467(Signal transduction histidine kinase, core)|interpro:IPR018955|interpro:IPR036784|interpro:IPR036890|interpro:IPR039028|rcsb pdb:1GJV|rcsb pdb:1GKX|rcsb pdb:1GKZ|rcsb pdb:3TZ0|rcsb pdb:3TZ2|rcsb pdb:3TZ4|rcsb pdb:3TZ5|rcsb pdb:3VAD|rcsb pdb:4DZY|rcsb pdb:4E00|rcsb pdb:4E01|rcsb pdb:4E02|rcsb pdb:4H7Q|rcsb pdb:4H81|rcsb pdb:4H85|reactome:R-RNO-70895	-	-	-	caution:"The participant EBI-349571(P68370) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919386(Q7TP47) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920972(Q5XIP9) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-916419(P11980) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919578(Q8R491) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920554(Q5U3Z7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920647(Q5U2X8) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920585(Q7TP24) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-779677(P05426) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-915744(P02454) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|agonist:Insulin was shown to increase or decrease GLUT4 protein interactions in specific cases.|comment:"Insulin decreased GLUT4 interactions with the following proteins: Q9ER30 (Sarcosin), P09527 (Rab-7), O88960 (N-ethylmaleimide sensitive), P09456 (PKA I regulatory subunit), P27881 (Hexokinase type II), P07872 (Acyl-coenzyme A oxidase), Q6DGF1 (Isocitrate dehydrogenase), Q9EQX9 (Ubiquitin-conjugating), Q63446 (Polyubiquitin), P24268 (Cathepsin D), Q91XW0 (Heat shock protein 86), Q5FVH0 (unknown), P58405 (Striatin 3), Q62667 (Major vault protein), Q66H50 (unknown), Q09167 (splicing factor), Q9JHU5 (Arfaptin 1)."|comment:"Insulin increased GLUT4 interaction with the following proteins:Q9Z1P2 (R-actinin-1), P45592 (Cofilin), Q9QXQ0 (R-actinin-4), P26473 (ADP-ribosylation factor), P26437 (ADP-ribosylation factor),   Q7TNP1 (Basigin 2), Q6P6R2 (Dihydrolipoamide dehydrogenase),   P04797 (GAPDH), Q63081 (Protein disulfide isomerase), P29457 (47 kDa heat shock protein), Q9R1J8 (Leprecan), O88638 (Putative eps protein),   Q64375 (Synaptonemal complex)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:NDPK - Interactions involving proteins containing InterPro domain IPR001564, Nucleoside diphosphate kinase, core.	taxid:10116(rat-l6)|taxid:10116(Rattus norvegicus)	-	2006/02/15	2021/11/30	rogid:PbFY2lfrty8yw40Jq7ShR7xfuV410116	rogid:6S1tPRyf/hEABum5/G8XSKt3Kas10116	intact-crc:44F3A2176D02515F|rigid:9RVm0UBcqQF4k06RGKO89Bg16Q8	false	myc tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P19357	uniprotkb:P97852	intact:EBI-915426|uniprotkb:P97900|ensembl:ENSRNOP00000023256	intact:EBI-918118|uniprotkb:P70523|uniprotkb:P70540|ensembl:ENSRNOP00000021646	psi-mi:glut4_rat(display_long)|uniprotkb:Glucose transporter type 4, insulin-responsive(gene name synonym)|uniprotkb:Slc2a4(gene name)|psi-mi:Slc2a4(display_short)|uniprotkb:Glut4(gene name synonym)	psi-mi:dhb4_rat(display_long)|uniprotkb:D-bifunctional protein(gene name synonym)|uniprotkb:17-beta-hydroxysteroid dehydrogenase 4(gene name synonym)|uniprotkb:Hsd17b4(gene name)|psi-mi:Hsd17b4(display_short)|uniprotkb:Edh17b4(gene name synonym)|uniprotkb:Multifunctional protein 2(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Foster et al. (2006)	pubmed:16396496|mint:MINT-5218203	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-921030	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2711|refseq:NP_036883.1|refseq:XP_006246658.1|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007611"(learning or memory)|go:"GO:0007614"(short-term memory)|go:"GO:0007616"(long-term memory)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010021"(amylopectin biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031550"(positive regulation of brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044381"(glucose import in response to insulin stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046323"(glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0098694"(regulation of synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0098793"(presynapse)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002441("Glucose transporter, type 4 (GLUT4)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-189200|ensembl:ENSRNOG00000017226(gene)|ensembl:ENSRNOT00000023256(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)	rgd:621806|refseq:NP_077368.2|ensembl:ENSRNOG00000015840(gene)|ensembl:ENSRNOT00000021646(transcript)|go:"GO:0000038"(very long-chain fatty acid metabolic process)|go:"GO:0003857"(3-hydroxyacyl-CoA dehydrogenase activity)|go:"GO:0004300"(enoyl-CoA hydratase activity)|go:"GO:0004303"(estradiol 17-beta-dehydrogenase activity)|go:"GO:0005777"(peroxisome)|go:"GO:0006635"(fatty acid beta-oxidation)|go:"GO:0007568"(aging)|go:"GO:0008203"(cholesterol metabolic process)|go:"GO:0008209"(androgen metabolic process)|go:"GO:0008210"(estrogen metabolic process)|go:"GO:0014070"(response to organic cyclic compound)|go:"GO:0016508"(long-chain-enoyl-CoA hydratase activity)|go:"GO:0016853"(isomerase activity)|go:"GO:0018812"(3-hydroxyacyl-CoA dehydratase activity)|go:"GO:0030283"("testosterone dehydrogenase [NAD(P)] activity")|go:"GO:0033989"(3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-enoyl-CoA hydratase activity)|go:"GO:0036111"(very long-chain fatty-acyl-CoA metabolic process)|go:"GO:0036112"(medium-chain fatty-acyl-CoA metabolic process)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0044594"("17-beta-hydroxysteroid dehydrogenase (NAD+) activity")|go:"GO:0048545"(response to steroid hormone)|go:"GO:0060009"(Sertoli cell development)|go:"GO:0071407"(cellular response to organic cyclic compound)|interpro:IPR002347(Glucose/ribitol dehydrogenase)|interpro:IPR002539(MaoC-like dehydratase)|interpro:IPR003033(Sterol-binding)|interpro:IPR029069|interpro:IPR036291|interpro:IPR036527|rcsb pdb:1GZ6|reactome:R-RNO-193368|reactome:R-RNO-2046106|reactome:R-RNO-389887|reactome:R-RNO-390247|reactome:R-RNO-9033241	-	-	-	caution:"The participant EBI-349571(P68370) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919386(Q7TP47) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920972(Q5XIP9) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-916419(P11980) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-919578(Q8R491) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920554(Q5U3Z7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920647(Q5U2X8) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-920585(Q7TP24) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-779677(P05426) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-915744(P02454) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|agonist:Insulin was shown to increase or decrease GLUT4 protein interactions in specific cases.|comment:"Insulin decreased GLUT4 interactions with the following proteins: Q9ER30 (Sarcosin), P09527 (Rab-7), O88960 (N-ethylmaleimide sensitive), P09456 (PKA I regulatory subunit), P27881 (Hexokinase type II), P07872 (Acyl-coenzyme A oxidase), Q6DGF1 (Isocitrate dehydrogenase), Q9EQX9 (Ubiquitin-conjugating), Q63446 (Polyubiquitin), P24268 (Cathepsin D), Q91XW0 (Heat shock protein 86), Q5FVH0 (unknown), P58405 (Striatin 3), Q62667 (Major vault protein), Q66H50 (unknown), Q09167 (splicing factor), Q9JHU5 (Arfaptin 1)."|comment:"Insulin increased GLUT4 interaction with the following proteins:Q9Z1P2 (R-actinin-1), P45592 (Cofilin), Q9QXQ0 (R-actinin-4), P26473 (ADP-ribosylation factor), P26437 (ADP-ribosylation factor),   Q7TNP1 (Basigin 2), Q6P6R2 (Dihydrolipoamide dehydrogenase),   P04797 (GAPDH), Q63081 (Protein disulfide isomerase), P29457 (47 kDa heat shock protein), Q9R1J8 (Leprecan), O88638 (Putative eps protein),   Q64375 (Synaptonemal complex)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:NDPK - Interactions involving proteins containing InterPro domain IPR001564, Nucleoside diphosphate kinase, core.	taxid:10116(rat-l6)|taxid:10116(Rattus norvegicus)	-	2006/02/15	2021/11/30	rogid:PbFY2lfrty8yw40Jq7ShR7xfuV410116	rogid:dYnJVA7smFYUVonOmzFB2Rx5/SM10116	intact-crc:44F3A2176D02515F|rigid:9RVm0UBcqQF4k06RGKO89Bg16Q8	false	myc tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P04797	uniprotkb:P19357	intact:EBI-349219|uniprotkb:P09328|ensembl:ENSRNOP00000040878|uniprotkb:Q5M916|uniprotkb:Q9QWU4|intact:EBI-6096024	intact:EBI-915426|uniprotkb:P97900|ensembl:ENSRNOP00000023256	psi-mi:g3p_rat(display_long)|uniprotkb:Gapdh(gene name)|psi-mi:Gapdh(display_short)|uniprotkb:38 kDa BFA-dependent ADP-ribosylation substrate(gene name synonym)|uniprotkb:BARS-38(gene name synonym)|uniprotkb:Gapd(gene name synonym)|uniprotkb:Peptidyl-cysteine S-nitrosylase GAPDH(gene name synonym)	psi-mi:glut4_rat(display_long)|uniprotkb:Glucose transporter type 4, insulin-responsive(gene name synonym)|uniprotkb:Slc2a4(gene name)|psi-mi:Slc2a4(display_short)|uniprotkb:Glut4(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Foster et al. (2006)	pubmed:16396496|mint:MINT-5218203	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-923337	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2661|refseq:NP_058704.1|ensembl:ENSRNOG00000018630(gene)|ensembl:ENSRNOT00000050443(transcript)|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0001819"(positive regulation of cytokine production)|go:"GO:0004365"("glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity")|interpro:IPR020831|interpro:IPR036291|mint:P04797|reactome:R-RNO-70171|reactome:R-RNO-70263|go:"GO:0005737"(cytoplasm)|go:"GO:0005811"(lipid droplet)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005975"(carbohydrate metabolic process)|go:"GO:0006094"(gluconeogenesis)|go:"GO:0006096"(glycolytic process)|go:"GO:0006915"(apoptotic process)|go:"GO:0007565"(female pregnancy)|go:"GO:0008017"(microtubule binding)|go:"GO:0010951"(negative regulation of endopeptidase activity)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0019828"(aspartic-type endopeptidase inhibitor activity)|go:"GO:0019899"(enzyme binding)|go:"GO:0019933"(cAMP-mediated signaling)|go:"GO:0031640"(killing of cells of another organism)|go:"GO:0005634"(nucleus)|go:"GO:0032481"(positive regulation of type I interferon production)|go:"GO:0050821"(protein stabilization)|go:"GO:0050832"(defense response to fungus)|go:"GO:0051287"(NAD binding)|go:"GO:0035605"(peptidyl-cysteine S-nitrosylase activity)|go:"GO:0051402"(neuron apoptotic process)|go:"GO:0051873"(killing by host of symbiont cells)|go:"GO:0035606"(peptidyl-cysteine S-trans-nitrosylation)|go:"GO:0060359"(response to ammonium ion)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0042802"(identical protein binding)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0097452"(GAIT complex)|go:"GO:0097718"(disordered domain specific binding)|go:"GO:0050661"(NADP binding)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|go:"GO:1905460"(negative regulation of vascular associated smooth muscle cell apoptotic process)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR006424(Glyceraldehyde-3-phosphate dehydrogenase, type I)|interpro:IPR020828|interpro:IPR020829|interpro:IPR020830|refseq:XP_017447924.1|refseq:XP_017458425.1	rgd:2711|refseq:NP_036883.1|refseq:XP_006246658.1|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007611"(learning or memory)|go:"GO:0007614"(short-term memory)|go:"GO:0007616"(long-term memory)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010021"(amylopectin biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031550"(positive regulation of brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044381"(glucose import in response to insulin stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046323"(glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0098694"(regulation of synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0098793"(presynapse)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002441("Glucose transporter, type 4 (GLUT4)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-189200|ensembl:ENSRNOG00000017226(gene)|ensembl:ENSRNOT00000023256(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)	-	-	-	comment:This interaction was only observed when cells were treated with 100nM insulin for 20 minutes at 37 degree celsius.|agonist:Insulin|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:NDPK - Interactions involving proteins containing InterPro domain IPR001564, Nucleoside diphosphate kinase, core.	taxid:10116(rat-l6)|taxid:10116(Rattus norvegicus)	-	2006/02/15	2014/10/16	rogid:4TDODEC0WVLzUSY2w1fVSmP9C5010116	rogid:PbFY2lfrty8yw40Jq7ShR7xfuV410116	intact-crc:2721C19BCF0B1453|rigid:ymjhVu8E2mQB2o2TTHmTwoXEFHE	false	-	myc tag:?-?	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q9QXQ0	uniprotkb:P19357	intact:EBI-919056|intact:EBI-923355|uniprotkb:Q6P786|ensembl:ENSRNOP00000027773	intact:EBI-915426|uniprotkb:P97900|ensembl:ENSRNOP00000023256	psi-mi:actn4_rat(display_long)|uniprotkb:Actn4(gene name)|psi-mi:Actn4(display_short)|uniprotkb:Non-muscle alpha-actinin 4(gene name synonym)	psi-mi:glut4_rat(display_long)|uniprotkb:Glucose transporter type 4, insulin-responsive(gene name synonym)|uniprotkb:Slc2a4(gene name)|psi-mi:Slc2a4(display_short)|uniprotkb:Glut4(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Foster et al. (2006)	pubmed:16396496|mint:MINT-5218203	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-923351	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:61816|refseq:NP_113863.2|ensembl:ENSRNOG00000020433(gene)|ensembl:ENSRNOT00000027773(transcript)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001725"(stress fiber)|go:"GO:0001882"(nucleoside binding)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005911"(cell-cell junction)|go:"GO:0015031"(protein transport)|go:"GO:0016922"(nuclear receptor binding)|go:"GO:0030018"(Z disc)|go:"GO:0030050"(vesicle transport along actin filament)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030374"(nuclear receptor coactivator activity)|go:"GO:0030863"(cortical cytoskeleton)|go:"GO:0031143"(pseudopodium)|go:"GO:0031490"(chromatin DNA binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0035357"(peroxisome proliferator activated receptor signaling pathway)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042974"(retinoic acid receptor binding)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043005"(neuron projection)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048384"(retinoic acid receptor signaling pathway)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048549"(positive regulation of pinocytosis)|go:"GO:0051015"(actin filament binding)|go:"GO:0051017"(actin filament bundle assembly)|go:"GO:0051271"(negative regulation of cellular component movement)|go:"GO:0051272"(positive regulation of cellular component movement)|go:"GO:0070830"(bicellular tight junction assembly)|go:"GO:1900025"(negative regulation of substrate adhesion-dependent cell spreading)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:1902396"(protein localization to bicellular tight junction)|go:"GO:1903506"(regulation of nucleic acid-templated transcription)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR001589(Actinin-type, actin-binding, conserved site)|interpro:IPR001715(Calponin-like actin-binding)|interpro:IPR002017(Spectrin repeat)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR011992(EF-Hand type)|interpro:IPR014837(EF-hand, Ca insensitive)|interpro:IPR018159|interpro:IPR018247|interpro:IPR036872|mint:Q9QXQ0|reactome:R-RNO-114608	rgd:2711|refseq:NP_036883.1|refseq:XP_006246658.1|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007611"(learning or memory)|go:"GO:0007614"(short-term memory)|go:"GO:0007616"(long-term memory)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010021"(amylopectin biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031550"(positive regulation of brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044381"(glucose import in response to insulin stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046323"(glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0098694"(regulation of synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0098793"(presynapse)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002441("Glucose transporter, type 4 (GLUT4)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-189200|ensembl:ENSRNOG00000017226(gene)|ensembl:ENSRNOT00000023256(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)	-	-	-	comment:"Insulin increased interaction between GLUT4 and alpha-actini-4. This effect was inhibited when cells were treated with 250nM latrunculin B treatment for 20 minutes prior to insulin (100nM) treatment for 20 minutes at 37 degree celsius."|agonist:Insulin increased interaction between GLUT4 and alpha-actini-4.|antagonist:Latrunculin B teatment reduced Insulin stimulated GLUT4 interaction with ACTN4.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:NDPK - Interactions involving proteins containing InterPro domain IPR001564, Nucleoside diphosphate kinase, core.	taxid:10116(rat-l6)|taxid:10116(Rattus norvegicus)	-	2006/02/15	2014/10/16	rogid:YdccQ9ahYoMqOKiNEbj5GgoXX0E10116	rogid:PbFY2lfrty8yw40Jq7ShR7xfuV410116	intact-crc:88DC5F68CED8C3EF|rigid:hyNacyZVhl6Zdbpi8ACdWqLckbM	false	-	myc tag:?-?	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P19357	uniprotkb:Q9QXQ0	intact:EBI-915426|uniprotkb:P97900|ensembl:ENSRNOP00000023256	intact:EBI-919056|intact:EBI-923355|uniprotkb:Q6P786|ensembl:ENSRNOP00000027773	psi-mi:glut4_rat(display_long)|uniprotkb:Glucose transporter type 4, insulin-responsive(gene name synonym)|uniprotkb:Slc2a4(gene name)|psi-mi:Slc2a4(display_short)|uniprotkb:Glut4(gene name synonym)	psi-mi:actn4_rat(display_long)|uniprotkb:Actn4(gene name)|psi-mi:Actn4(display_short)|uniprotkb:Non-muscle alpha-actinin 4(gene name synonym)	psi-mi:"MI:0416"(fluorescence microscopy)	Foster et al. (2006)	pubmed:16396496|mint:MINT-5218203	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:0469"(IntAct)	intact:EBI-923380	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2711|refseq:NP_036883.1|refseq:XP_006246658.1|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0007611"(learning or memory)|go:"GO:0007614"(short-term memory)|go:"GO:0007616"(long-term memory)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010021"(amylopectin biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031550"(positive regulation of brain-derived neurotrophic factor receptor signaling pathway)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044381"(glucose import in response to insulin stimulus)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046323"(glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0098694"(regulation of synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0098793"(presynapse)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002441("Glucose transporter, type 4 (GLUT4)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-RNO-189200|ensembl:ENSRNOG00000017226(gene)|ensembl:ENSRNOT00000023256(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)	rgd:61816|refseq:NP_113863.2|ensembl:ENSRNOG00000020433(gene)|ensembl:ENSRNOT00000027773(transcript)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001725"(stress fiber)|go:"GO:0001882"(nucleoside binding)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005911"(cell-cell junction)|go:"GO:0015031"(protein transport)|go:"GO:0016922"(nuclear receptor binding)|go:"GO:0030018"(Z disc)|go:"GO:0030050"(vesicle transport along actin filament)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030374"(nuclear receptor coactivator activity)|go:"GO:0030863"(cortical cytoskeleton)|go:"GO:0031143"(pseudopodium)|go:"GO:0031490"(chromatin DNA binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0035357"(peroxisome proliferator activated receptor signaling pathway)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042974"(retinoic acid receptor binding)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043005"(neuron projection)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048384"(retinoic acid receptor signaling pathway)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048549"(positive regulation of pinocytosis)|go:"GO:0051015"(actin filament binding)|go:"GO:0051017"(actin filament bundle assembly)|go:"GO:0051271"(negative regulation of cellular component movement)|go:"GO:0051272"(positive regulation of cellular component movement)|go:"GO:0070830"(bicellular tight junction assembly)|go:"GO:1900025"(negative regulation of substrate adhesion-dependent cell spreading)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:1902396"(protein localization to bicellular tight junction)|go:"GO:1903506"(regulation of nucleic acid-templated transcription)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR001589(Actinin-type, actin-binding, conserved site)|interpro:IPR001715(Calponin-like actin-binding)|interpro:IPR002017(Spectrin repeat)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR011992(EF-Hand type)|interpro:IPR014837(EF-hand, Ca insensitive)|interpro:IPR018159|interpro:IPR018247|interpro:IPR036872|mint:Q9QXQ0|reactome:R-RNO-114608	-	-	-	comment:"Authors state that \"Insulin acutely promotes dorsal actin  remodeling causing membrane ruffles in these cells,37,38 and  therefore the fluorescent images of R-actinin-4, GLUT4myc and  actin shown in Figure 6b focus on the dorsal plane of the  myotubes.\""|agonist:Insulin promoted GLUT4 and ACTN4 colocalisation.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:NDPK - Interactions involving proteins containing InterPro domain IPR001564, Nucleoside diphosphate kinase, core.	taxid:10116(rat-l6)|taxid:10116(Rattus norvegicus)	-	2006/02/15	2014/10/16	rogid:PbFY2lfrty8yw40Jq7ShR7xfuV410116	rogid:YdccQ9ahYoMqOKiNEbj5GgoXX0E10116	intact-crc:494FD4B5C92196C0|rigid:hyNacyZVhl6Zdbpi8ACdWqLckbM	false	myc tag:?-?	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)